BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0003.p (713 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2424_3 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 327 5e-89 PA2399_2 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 325 2e-88 PA2399_1 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 318 3e-86 BS_srfAB_2 [Q] COG1020 Non-ribosomal peptide synthetase modules ... 314 4e-85 PA2400 [Q] COG1020 Non-ribosomal peptide synthetase modules and ... 305 3e-82 >PA2424_3 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1520 Score = 327 bits (839), Expect = 5e-89, Method: Compositional matrix adjust. Identities = 244/628 (38%), Positives = 326/628 (51%), Gaps = 36/628 (5%) Query: 1 VRTRIDERSDFLALMRQVQQAVQEAQAHQDLPLDALVSALQPERVAGANPLFQVKCT-QQ 59 +R R+D + L+ QV+Q V + Q+HQDLP D LV ALQP R A NPLFQV C Q+ Sbjct: 303 LRCRLDGQMSVGELLEQVRQTVIDGQSHQDLPFDHLVEALQPPRSAAYNPLFQVMCNVQR 362 Query: 60 QAIATVRRMGGLDMRVELQANAE--SHFDLSLDFTDADEGIDILLAYAPALFDAETVAGF 117 R++ G M VE AN + FDL+L+ TD D+ + L Y+ LFD +A Sbjct: 363 WEFQQTRQLAG--MTVEYIANDARATKFDLNLEVTDLDQRLGCCLTYSRDLFDEPRIARM 420 Query: 118 AGLLQALAQQVVAAPALALADLQAFPPISAADQVLQP-----------AEDVAACWRRQA 166 AG Q L + ++ P +A+L P+ AA++ Q + + + + Sbjct: 421 AGHWQNLLEALLGDPQRRIAEL----PLFAAEERKQLLLAGTAGEAGLQDTLHGLFAARV 476 Query: 167 LAQPDAVALRCGAQFISNVQLLQRIDALAQRLHAAGAGPESRVALYAGRGIDFVCGMLAV 226 A P A AL Q +S +L R + LA+ L + G GPE RV L R ++ V G+LA+ Sbjct: 477 AASPQAPALTFAGQTLSYAELDARSNRLARVLRSHGVGPEVRVGLALERSLEMVVGLLAI 536 Query: 227 LDTGAAYVPLDPQLPAERLAWQLQDSGARWVL-HEGQSAPAWLAQAGVPLLSLEAAGTAP 285 L G AYVPLDP+ P ERL + ++DSG R +L H AGV LE G A Sbjct: 537 LKAGGAYVPLDPEYPLERLQYMIEDSGVRLLLSHAALFEALGELPAGVARWCLEEDGPAL 596 Query: 286 ASPWTPFPVH----PAQAAYLIYTSGSTGRPKGVLVTRGGLANYVAAVLEKLALPAAARS 341 + P P+ P AYLIYTSGSTG+PKGV V+ G +A + AAV+E + A Sbjct: 597 DAE-DPAPLAALSGPQHQAYLIYTSGSTGKPKGVAVSHGEIAMHCAAVIECFGMRAEDCE 655 Query: 342 MAMISTVAADLGHTTLYGALCSGRQLHLITHDLAFDPDGFAAYLHEHAVDVLKIVPSHLQ 401 + S L LC R ++ + + + V +L PS+ Sbjct: 656 LHFYSINFDAASERLLAPLLCGARV--VLRAQGQWGAEEICELIRAEGVSILGFTPSYGS 713 Query: 402 ALLHAARPE-QVLPRHTLVLGGEATGWPLLERI-AALQPACRVLNHYGPSETTVGVLAQE 459 L + + LP + GGEA L+RI A PA N YGP+ET V LA Sbjct: 714 QLAQWLESQGRQLPVRMCITGGEALTGEHLQRIRQAFAPAS-FFNAYGPTETVVMPLACL 772 Query: 460 AASASRR-AAVLPVGSALAGVQAWVLDRQLRRAPVGAVGELYLGGAGLARGYHGRAALTA 518 A AA +P+GS + A++LD L P GA GELY+GGAGLARGYH R AL+A Sbjct: 773 APERLEEGAASVPIGSVVGARVAYILDADLALVPQGATGELYVGGAGLARGYHERPALSA 832 Query: 519 ERFVAHPF-ASGQRLYRSGDRARYLGDGSIEFLGRIDDQVKIRGHRVEPGEVRQQLLRLA 577 ERFV PF A G RLYR+GD R +G +E++GRID QVKIRG R+E GE+ +LL Sbjct: 833 ERFVPDPFAAEGGRLYRTGDLVRLCDNGQVEYVGRIDHQVKIRGFRIELGEIEARLLEHP 892 Query: 578 GVVDAAVLALPAADDAQRLQLHGFIVCA 605 V +A VLAL D QL G++ A Sbjct: 893 QVREALVLAL---DSPSGKQLAGYVASA 917 >PA2399_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1060 Score = 325 bits (833), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 242/638 (37%), Positives = 332/638 (52%), Gaps = 36/638 (5%) Query: 1 VRTRIDERSDFLALMRQVQQAVQEAQAHQDLPLDALVSALQPERVAGANPLFQVKCTQQQ 60 ++ +D R F L+ Q +Q EAQAHQDLP + LV ALQPER A NPLFQV Q Sbjct: 291 LKADLDGRMGFDELLAQARQRALEAQAHQDLPFEQLVEALQPERNASHNPLFQVLFNHQS 350 Query: 61 AIATVRRMGGL-DMRVELQA--NAESHFDLSLDFTDADEGIDILLAYAPALFDAETVAGF 117 I +V L D+R+E A + FDL+LD + + GI YA LFDA TV Sbjct: 351 EIRSVTPEVQLEDLRLEGLAWDGQTAQFDLTLDIQEDENGIWASFDYATDLFDASTVERL 410 Query: 118 AGLLQALAQQVVAAPALALADLQAFPPISAAD--QVL---QPAEDVAAC-------WRRQ 165 AG + L + +VA P L +L P + A + Q L PA+ A + Q Sbjct: 411 AGHWRNLLRGIVANPRQRLGEL---PLLDAPERRQTLSEWNPAQRECAVQGTLQQRFEEQ 467 Query: 166 ALAQPDAVALRCGAQFISNVQLLQRIDALAQRLHAAGAGPESRVALYAGRGIDFVCGMLA 225 A +P AVAL Q +S +L R + LA L A G G + V L R +D + G+LA Sbjct: 468 ARQRPQAVALILDEQRLSYGELNARANRLAHCLIARGVGADVPVGLALERSLDMLVGLLA 527 Query: 226 VLDTGAAYVPLDPQLPAERLAWQLQDSGARWVLHEGQSAPAWLAQAGVPLLSLEAAGTAP 285 +L G AY+PLDP P ERLA L DSG R +L +G QAGV +L+++ Sbjct: 528 ILKAGGAYLPLDPAAPEERLAHILDDSGVRLLLTQGHLLERLPRQAGVEVLAIDGLVLDG 587 Query: 286 ASPWTPFPVHPA-QAAYLIYTSGSTGRPKGVLVTRGGLANYVAAVLEKLALPAAARSMAM 344 + P P A AY+IYTSGSTG+PKG L+T +A + Sbjct: 588 YAESDPLPTLSADNLAYVIYTSGSTGKPKGTLLTHRNALRLFSATEAWFGFDERD-VWTL 646 Query: 345 ISTVAADLGHTTLYGALCSGRQLHLITHDLAFDPDGFAAYLHEHAVDVLKIVPSHLQALL 404 + A D ++GAL G +L ++ ++ P+ F L V VL PS + L+ Sbjct: 647 FHSYAFDFSVWEIFGALLYGGRLVIVPQWVSRSPEDFYRLLCREGVTVLNQTPSAFKQLM 706 Query: 405 HAARPEQVLPRH----TLVLGGEATGW----PLLERIAALQPACRVLNHYGPSETTVGVL 456 A + + ++ GGEA P +R QP +++N YG +ETTV V Sbjct: 707 AVACSADMATQQPALRYVIFGGEALDLQSLRPWFQRFGDRQP--QLVNMYGITETTVHVT 764 Query: 457 AQEAASASRRAAVL-PVGSALAGVQAWVLDRQLRRAPVGAVGELYLGGAGLARGYHGRAA 515 + + A + ++ P+G + + ++LDR L P GAVGELY+G AGLARGY R Sbjct: 765 YRPVSEADLKGGLVSPIGGTIPDLSWYILDRDLNPVPRGAVGELYIGRAGLARGYLRRPG 824 Query: 516 LTAERFVAHPF--ASGQRLYRSGDRARYLGDGSIEFLGRIDDQVKIRGHRVEPGEVRQQL 573 L+A RFV +PF +G+RLYR+GD AR+ DG+IE++GRID QVK+RG R+E GE+ L Sbjct: 825 LSATRFVPNPFPGGAGERLYRTGDLARFQADGNIEYIGRIDHQVKVRGFRIELGEIEAAL 884 Query: 574 LRLAGVVDAAVLALPAADDAQRLQLHGFIVCAAGAVAD 611 LAGV DA VL A D QL G++V + A+ Sbjct: 885 AGLAGVRDAVVL---AHDGVGGTQLVGYVVADSAEDAE 919 >PA2399_1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1105 Score = 318 bits (815), Expect = 3e-86, Method: Compositional matrix adjust. Identities = 237/638 (37%), Positives = 325/638 (50%), Gaps = 36/638 (5%) Query: 1 VRTRIDERSDFLALMRQVQQAVQEAQAHQDLPLDALVSALQPERVAGANPLFQVKCTQQ- 59 ++ +D R F L+ Q +Q EAQAHQDLP + LV ALQPER NPLFQV Q Sbjct: 335 LKADLDGRMGFDELLAQARQRALEAQAHQDLPFEQLVEALQPERSLSHNPLFQVLFNYQS 394 Query: 60 --QAIATVRRMGGLDMRVELQANAESHFDLSLDFTDADEGIDILLAYAPALFDAETVAGF 117 + R L M + + FDL+LD TD ++ + YA LFDA TV Sbjct: 395 EARGNGQAFRFDELQMESVQFDSRTAQFDLTLDLTDEEQRFCAVFDYATDLFDASTVERL 454 Query: 118 AGLLQALAQQVVAAPALALADLQAFPPISAAD--QVL---QPAEDVAAC-------WRRQ 165 AG + L + +VA P L +L P + A + Q L PA+ A + Q Sbjct: 455 AGHWRNLLRGIVANPRQRLGEL---PLLDAPERRQTLSEWNPAQRECAVQGTLQQRFEEQ 511 Query: 166 ALAQPDAVALRCGAQFISNVQLLQRIDALAQRLHAAGAGPESRVALYAGRGIDFVCGMLA 225 A +P AVAL Q +S +L R + LA L A G G + V L R +D + G+LA Sbjct: 512 ARQRPQAVALILDEQRLSYGELNARANRLAHCLIARGVGADVPVGLALERSLDMLVGLLA 571 Query: 226 VLDTGAAYVPLDPQLPAERLAWQLQDSGARWVLHEGQSAPAWLAQAGVPLLSLEAAGTAP 285 +L G AY+PLDP P ERLA L DSG R +L +G QAGV +L+++ Sbjct: 572 ILKAGGAYLPLDPAAPEERLAHILDDSGVRLLLTQGHLLERLPRQAGVEVLAIDGLVLDG 631 Query: 286 ASPWTPFPVHPA-QAAYLIYTSGSTGRPKGVLVTRGGLANYVAAVLEKLALPAAARSMAM 344 + P P A AY+IYTSGSTG+PKG L+T +A + Sbjct: 632 YAESDPLPTLSADNLAYVIYTSGSTGKPKGTLLTHRNALRLFSATEAWFGFDERD-VWTL 690 Query: 345 ISTVAADLGHTTLYGALCSGRQLHLITHDLAFDPDGFAAYLHEHAVDVLKIVPSHLQALL 404 + A D ++GAL G L ++ ++ P+ F L V VL PS + L+ Sbjct: 691 FHSYAFDFSVWEIFGALLYGGCLVIVPQWVSRSPEDFYRLLCREGVTVLNQTPSAFKQLM 750 Query: 405 HAARPEQVLPRH----TLVLGGEATGW----PLLERIAALQPACRVLNHYGPSETTVGVL 456 A + + ++ GGEA P +R QP +++N YG +ETTV V Sbjct: 751 AVACSADMATQQPALRYVIFGGEALDLQSLRPWFQRFGDRQP--QLVNMYGITETTVHVT 808 Query: 457 AQEAASASRRAAVL-PVGSALAGVQAWVLDRQLRRAPVGAVGELYLGGAGLARGYHGRAA 515 + + A ++ P+G + + ++LDR L P GAVGELY+G AGLARGY R Sbjct: 809 YRPVSEADLEGGLVSPIGGTIPDLSWYILDRDLNPVPRGAVGELYIGRAGLARGYLRRPG 868 Query: 516 LTAERFVAHPF--ASGQRLYRSGDRARYLGDGSIEFLGRIDDQVKIRGHRVEPGEVRQQL 573 L+A RFV +PF +G+RLYR+GD AR+ DG+IE++GRID QVK+RG R+E GE+ L Sbjct: 869 LSATRFVPNPFPGGAGERLYRTGDLARFQADGNIEYIGRIDHQVKVRGFRIELGEIEAAL 928 Query: 574 LRLAGVVDAAVLALPAADDAQRLQLHGFIVCAAGAVAD 611 LAGV DA VL A D QL G++V + A+ Sbjct: 929 AGLAGVRDAVVL---AHDGVGGTQLVGYVVADSAEDAE 963 >BS_srfAB_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Bsu Bacillus subtilis Length = 1045 Score = 314 bits (805), Expect = 4e-85, Method: Compositional matrix adjust. Identities = 195/596 (32%), Positives = 308/596 (51%), Gaps = 23/596 (3%) Query: 11 FLALMRQVQQAVQEAQAHQDLPLDALVSALQPERVAGANPLFQVKCTQQQAIATVRRMGG 70 F + +V+ A +A HQ PL+ L+ L R +PLF V Q R+G Sbjct: 295 FAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTRDTSRSPLFSVMFNMQNMEIPSLRLGD 354 Query: 71 LDMRVELQANAESHFDLSLDFTDADEGIDILLAYAPALFDAETVAGFAGLLQALAQQVVA 130 L + + + FDLSL+ + +E I + YA ALF ET+ ++ + + A Sbjct: 355 LKISSYSMLHHVAKFDLSLEAVEREEDIGLSFDYATALFKDETIRRWSRHFVNIIKAAAA 414 Query: 131 APALALADLQAFPPISAA-----DQVLQPAE-DVAACWRRQALAQPDAVALRCGAQFISN 184 P + L+D+ A + Q E AA + +QA PD A++ G ++ Sbjct: 415 NPNVRLSDVDLLSSAETAALLEERHMTQITEATFAALFEKQAQQTPDHSAVKAGGNLLTY 474 Query: 185 VQLLQRIDALAQRLHAAGAGPESRVALYAGRGIDFVCGMLAVLDTGAAYVPLDPQLPAER 244 +L ++ + LA L A GAG E VA+ R + + +L V+ GAA++P+DP P ER Sbjct: 475 RELDEQANQLAHHLRAQGAGNEDIVAIVMDRSAEVMVSILGVMKAGAAFLPIDPDTPGER 534 Query: 245 LAWQLQDSGARWVLHEGQSAPAWLAQAGVPLLSLEAAGTAPASPWTPFPVHPAQA-AYLI 303 + + L+DSGA++ + ++ A G+ ++SL+ S P + ++ AY+I Sbjct: 535 IRYSLEDSGAKFAVVNERNMTAIGQYEGI-IVSLDDGKWRNESKERPSSISGSRNLAYVI 593 Query: 304 YTSGSTGRPKGVLVTRGGLANYVAAVLEKLALPA----AARSMAMISTVAADLGHTTLYG 359 YTSG+TG+PKGV + L NYV+ E+ L ++S+ A DLG+T ++ Sbjct: 594 YTSGTTGKPKGVQIEHRNLTNYVSWFSEEAGLTKRRADGNDKTVLLSSYAFDLGYTCMFP 653 Query: 360 ALCSGRQLHLITHDLAFDPDGFAAYLHEHAVDVLKIVPSHLQALLHAAR---PEQVLPRH 416 L G +LH++ + PD A Y+ EH + +K+ PS +++ A Sbjct: 654 VLLGGGELHIVQKETYTAPDEIAHYIKEHGITYIKLTPSLFHTIVNTASFAFDANFESLR 713 Query: 417 TLVLGGEATGWPLLERIAALQPACRVLNHYGPSETTVGVLA-----QEAASASRRAAVLP 471 +VLGGE + + +NHYGP+E T+G +A E + ++R + Sbjct: 714 LIVLGGEKIIPTDVIAFRKMYGHTEFINHYGPTEATIGAIAGRVDLYEPDAFAKRPTI-- 771 Query: 472 VGSALAGVQAWVLDRQLRRAPVGAVGELYLGGAGLARGYHGRAALTAERFVAHPFASGQR 531 G +A A VL+ L+ P GA G+LY+ G GLARGY R LTAERFV +P++ G Sbjct: 772 -GRPIANAGALVLNEALKLVPPGASGQLYITGQGLARGYLNRPQLTAERFVENPYSPGSL 830 Query: 532 LYRSGDRARYLGDGSIEFLGRIDDQVKIRGHRVEPGEVRQQLLRLAGVVDAAVLAL 587 +Y++GD R L DG++ F+GR DDQVKIRG+R+E GE+ +L L+G+ +A VLA+ Sbjct: 831 MYKTGDVVRRLSDGTLAFIGRADDQVKIRGYRIELGEIETVMLSLSGIQEAVVLAV 886 >PA2400 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1317 Score = 305 bits (780), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 240/643 (37%), Positives = 321/643 (49%), Gaps = 53/643 (8%) Query: 1 VRTRIDERSDFLALMRQVQQAVQEAQAHQDLPLDALVSALQPERVAGANPLFQVKCTQQ- 59 ++ ID + F L+ QV+Q EAQAHQDLP + LV ALQPER +PLFQV Q Sbjct: 529 LKADIDGQMGFDRLLHQVRQRSLEAQAHQDLPFEQLVEALQPERSLSHSPLFQVLFNYQA 588 Query: 60 -QAIATVRRMGGLDMRVELQANAESHFDLSLDFTDADEGIDILLAYAPALFDAETVAGFA 118 + + + GL + + + + FDL LD +++ I L YA LFDA T Sbjct: 589 ERGEHGLPEVAGLSIEEQAWESHTAQFDLVLDTCESESDIWAALVYATDLFDASTAERLV 648 Query: 119 GLLQALAQQVVAAPALALADLQAFPPISAADQVLQPAEDVAACWRR------------QA 166 Q L ++A P L +L D+ + E + W R Q Sbjct: 649 RHWQNLLDAILAMPDARLGELDML------DR--EEREVIGQLWNRSDSGYPATPLVHQR 700 Query: 167 LAQ-----PDAVALRCGAQFISNVQLLQRIDALAQRLHAAGAGPESRVALYAGRGIDFVC 221 +A+ PDAVA+ + ++ +L R + LA L A G GPE RVA+ R + + Sbjct: 701 VAERARMAPDAVAVIFDEEKLTYAELDNRANRLAHALIARGVGPEVRVAIAMQRSAEIMV 760 Query: 222 GMLAVLDTGAAYVPLDPQLPAERLAWQLQDSGARWVLHEGQSAPAWLAQAGVPLLSLEAA 281 LAVL G AYVPLD + P ERL + +QDS A +L G+ LS++ Sbjct: 761 AFLAVLKAGGAYVPLDIEYPRERLLYMMQDSRAHLLLTHSHLLERLPIPEGLSCLSVDRE 820 Query: 282 GTAPASPWTPFPVHPAQAA-------YLIYTSGSTGRPKGVLVTRGGLANYVAAVLEKLA 334 W FP H + A Y+IYTSGSTG PKGV V+ G L ++ A E+ Sbjct: 821 -----EEWAGFPAHDPEVALHGDNLAYVIYTSGSTGMPKGVAVSHGPLIAHIVATGERYE 875 Query: 335 LPAAARSMAMISTVAADLGHTTLYGALCSGRQLHLITHDLAFDPDGFAAYLHEHAVDVLK 394 + + +S A D H L +G ++ LI D + P+ A +H H V V Sbjct: 876 MTPEDCELHFMS-FAFDGSHEGWMHPLINGARV-LIRDDSLWLPERTYAEMHRHGVTVGV 933 Query: 395 IVPSHLQALL-HAARPEQVLPRHTLVLGGEAT---GWPLLERIAALQPACRVLNHYGPSE 450 P +LQ L HA R P GG+A + L R AL+P + N YGP+E Sbjct: 934 FPPVYLQQLAEHAERDGNPPPVRVYCFGGDAVAQASYDLAWR--ALKPKY-LFNGYGPTE 990 Query: 451 TTVGVLAQEA-ASASRRAAVLPVGSALAGVQAWVLDRQLRRAPVGAVGELYLGGAGLARG 509 T V L +A A + AA +P+G+ L ++LD QL PVG GELYLGG G+ARG Sbjct: 991 TVVTPLLWKARAGDACGAAYMPIGTLLGNRSGYILDGQLNLLPVGVAGELYLGGEGVARG 1050 Query: 510 YHGRAALTAERFVAHPF-ASGQRLYRSGDRARYLGDGSIEFLGRIDDQVKIRGHRVEPGE 568 Y R ALTAERFV PF A G RLYRSGD R DG +++LGR+D QVKIRG R+E GE Sbjct: 1051 YLERPALTAERFVPDPFGAPGSRLYRSGDLTRGRADGVVDYLGRVDHQVKIRGFRIELGE 1110 Query: 569 VRQQLLRLAGVVDAAVLALPAADDAQRLQLHGFIVCAAGAVAD 611 + +L V +A V+A P A QL G++V AVAD Sbjct: 1111 IEARLREHPAVREAVVVAQPGAVGQ---QLVGYVVAQEPAVAD 1150 Score = 83.6 bits (205), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 44/73 (60%), Positives = 53/73 (72%), Gaps = 1/73 (1%) Query: 516 LTAERFVAHPFAS-GQRLYRSGDRARYLGDGSIEFLGRIDDQVKIRGHRVEPGEVRQQLL 574 +TAERF+ PF G RLYR+GD AR GDG IE++GR D QVKIRG R+E GEV +LL Sbjct: 1 MTAERFLPDPFGEPGSRLYRTGDLARRRGDGVIEYMGRADHQVKIRGFRIELGEVEARLL 60 Query: 575 RLAGVVDAAVLAL 587 L G+ +AA LAL Sbjct: 61 DLEGIREAAALAL 73