BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0020.0145.p (465 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2527 [L] COG1570 Exonuclease VII, large subunit Rso Ralstonia... 436 e-122 NMA1575 [L] COG1570 Exonuclease VII, large subunit NmA Neisseria... 379 e-105 NMB1363 [L] COG1570 Exonuclease VII, large subunit Nme Neisseria... 378 e-104 xseA [L] COG1570 Exonuclease VII, large subunit Eco Escherichia ... 335 1e-91 STM2512 [L] COG1570 Exonuclease VII, large subunit Sty Salmonell... 332 1e-90 >RSc2527 [L] COG1570 Exonuclease VII, large subunit Rso Ralstonia solanacearum Length = 440 Score = 436 bits (1121), Expect = e-122, Method: Compositional matrix adjust. Identities = 244/437 (55%), Positives = 306/437 (70%) Query: 28 MLTVSALNQAVGRMLERNFPLLWVKGEVSNFTRAASGHWYFNLKDEGAQVRAVMFKGRAQ 87 ML+VS +N+ + +LER+F L WV+GE+SNFTRA SGHWYF+LKD GAQ+R VMFKGR Q Sbjct: 1 MLSVSEVNRRIAGLLERHFALGWVRGEISNFTRAGSGHWYFSLKDAGAQIRCVMFKGRNQ 60 Query: 88 YAGFMPREGDKVEVRTLVTLYAPRGDYQLNVEAIRRSGVGDLYAAFLQLKERLEREGLFA 147 YA F PREG+ +EVR LVTLY RG+ QL+VEAIRR+G+G+LY AFL+LK LE +GLF Sbjct: 61 YADFTPREGEAIEVRALVTLYEARGELQLSVEAIRRAGLGNLYEAFLRLKAALEAQGLFD 120 Query: 148 RERKRALPGFPRRIGIVTSPQAAALRDVLTTLRRRAPHVEVVLYPTPVQGEGAGQRIAAA 207 RKR LP P IG+VTS QAAALRDVLTTL RRAPHV VV+YP PVQG GA +RIAA Sbjct: 121 AARKRPLPRHPHAIGVVTSLQAAALRDVLTTLHRRAPHVPVVVYPVPVQGAGAAERIAAM 180 Query: 208 IGRASERAECDVLLVCRGGGSIEDLWSFNEEVVARAIVATTMPVISGVGHETDFTIADFA 267 + + RAE DV+++CRGGGSIEDLW+FNEE VARA+ A+ +P+++GVGHETD TI DF Sbjct: 181 LDLVNARAEVDVIILCRGGGSIEDLWAFNEEPVARAVAASDIPIVAGVGHETDVTIVDFV 240 Query: 268 ADLRAPTPTAAAELAASARQDWLAELRGHAADLTRALRHTLADKAQSVDWLSRRLVSPSA 327 AD+RAPTPT AAEL + R L ++ G L+ LR L +AQ+VDWL+RRL SP A Sbjct: 241 ADVRAPTPTGAAELVSPDRARMLRDVAGCWDALSATLRRQLDRRAQTVDWLARRLRSPQA 300 Query: 328 YIQHERVKLLALQNRLSHANQIPLTRMRHGLQQLASRLAHQLPDTRHARRDLAELARRLQ 387 ++ R L L+ RL A + R HG + LA RL PD R L + L Sbjct: 301 QMRERRAGLAHLEGRLRFALHGRVQRAEHGQRLLAMRLDAARPDIARERTALQGIEAALA 360 Query: 388 RAQGAQQSAQRQTLTTLHSKLELLNPQRTLERGYAIVSDHQGRVLHSPAELAARSEITIR 447 RA A + L+ + LELL PQRTLERGYA++ D +G+ + PA L AR+ I R Sbjct: 361 RAMRATLDRAQTRLSHHQAGLELLAPQRTLERGYAVLLDAKGQAIRDPAALHARARIEAR 420 Query: 448 LAQGSAEVGIASVQPRL 464 LA+G+ ++ IA VQP+L Sbjct: 421 LARGAVDIEIAQVQPKL 437 >NMA1575 [L] COG1570 Exonuclease VII, large subunit NmA Neisseria meningitidis Z2491 Length = 451 Score = 379 bits (973), Expect = e-105, Method: Compositional matrix adjust. Identities = 205/445 (46%), Positives = 281/445 (63%), Gaps = 14/445 (3%) Query: 28 MLTVSALNQAVGRMLERNFPLLWVKGEVSNFTRAASGHWYFNLKDEGAQVRAVMFKGRAQ 87 +L+VS LN +LE + LW+ GEVSN TRAASGH+YF+LKD AQVR MFKG A Sbjct: 9 VLSVSELNAFAKSLLENHLAGLWIAGEVSNLTRAASGHYYFSLKDSRAQVRCAMFKGAAA 68 Query: 88 YAGFMPREGDKVEVRTLVTLYAPRGDYQLNVEAIRRSGVGDLYAAFLQLKERLEREGLFA 147 +EGD +EV +++Y RG++Q+ V +R G+G LY A+ +LK +L+ EG FA Sbjct: 69 RLAKPLKEGDHIEVSGKISIYEARGEFQITVNEVRLKGLGQLYEAYERLKAQLQAEGAFA 128 Query: 148 RERKRALPGFPRRIGIVTSPQAAALRDVLTTLRRRAPHVEVVLYPTPVQGEGAGQRIAAA 207 ERK+ LP P+ IGIVTS AAALRDV+TTL+RRAP + V++YPTPVQG G+ +IA A Sbjct: 129 AERKKPLPTRPQCIGIVTSLAAAALRDVVTTLKRRAPEIPVIVYPTPVQGAGSELQIAQA 188 Query: 208 IGRASERAECDVLLVCRGGGSIEDLWSFNEEVVARAIVATTMPVISGVGHETDFTIADFA 267 I AS+RAECDVL+VCRGGGSIEDLW+FNEE V RAI A T+PV+SGVGHETDFT+ADF Sbjct: 189 IKTASQRAECDVLIVCRGGGSIEDLWAFNEEPVVRAIEACTVPVVSGVGHETDFTLADFV 248 Query: 268 ADLRAPTPTAAAELAASARQDWLAELRGHAADLTRALRHTLADKAQSVDWLSRRLVSPSA 327 AD+RAPTPT AAEL + RQ+ L L L L D +Q +DWL+R++ P Sbjct: 249 ADVRAPTPTGAAELVSPNRQESLHRLAQAQGRLKTVLEQRYFDASQKLDWLARQIRHPRQ 308 Query: 328 YIQHERVKLLALQNRLSHANQIPLTRMRHGLQQLASRLAHQLPDTRHARRDLAELARRLQ 387 + +R + L LS++ M+ L+ +R Q +H R D++ + Sbjct: 309 KLDEQRASIGKLAQTLSYS-------MKQNLRAHTARFERQTQALQHYRPDVSVCKNNIV 361 Query: 388 RAQGAQQSA-------QRQTLTTLHSKLELLNPQRTLERGYAIVSDHQGRVLHSPAELAA 440 R Q A +A +RQ+LT + LE ++PQ LERG+++V + +G+V+ + L Sbjct: 362 RLQTALPAAFSQLLTHRRQSLTAQAALLEAVSPQHILERGFSVVKNTRGQVIRNADVLKQ 421 Query: 441 RSEITIRLAQGSAEVGIASVQPRLD 465 ++ I A G +V ++ Q + D Sbjct: 422 GQKLHITFADGETDVRVSKEQGQQD 446 >NMB1363 [L] COG1570 Exonuclease VII, large subunit Nme Neisseria meningitidis MC58 Length = 451 Score = 378 bits (971), Expect = e-104, Method: Compositional matrix adjust. Identities = 203/445 (45%), Positives = 280/445 (62%), Gaps = 14/445 (3%) Query: 28 MLTVSALNQAVGRMLERNFPLLWVKGEVSNFTRAASGHWYFNLKDEGAQVRAVMFKGRAQ 87 +L+VS LN +LE + LW+ GEVSN TRAASGH+YF+LKD AQVR MFKG A Sbjct: 9 VLSVSELNAFAKSLLENHLAGLWIAGEVSNLTRAASGHYYFSLKDSRAQVRCAMFKGAAV 68 Query: 88 YAGFMPREGDKVEVRTLVTLYAPRGDYQLNVEAIRRSGVGDLYAAFLQLKERLEREGLFA 147 +EGD +EV +++Y RG++Q+ V +R G+G LY A+ +LK +L+ EG FA Sbjct: 69 RLAKPLKEGDHIEVSGKISIYEARGEFQITVNEVRLKGLGQLYEAYERLKAQLQAEGAFA 128 Query: 148 RERKRALPGFPRRIGIVTSPQAAALRDVLTTLRRRAPHVEVVLYPTPVQGEGAGQRIAAA 207 ERK+ LP P+ IGIVTS AAALRDV+TTL+RRAP + V++YPTPVQG G+ +IA A Sbjct: 129 AERKKPLPVRPQCIGIVTSLAAAALRDVVTTLKRRAPEIPVIVYPTPVQGAGSELQIAQA 188 Query: 208 IGRASERAECDVLLVCRGGGSIEDLWSFNEEVVARAIVATTMPVISGVGHETDFTIADFA 267 I AS+RAECDVL+VCRGGGSIEDLW+FNEE V RAI + T+PV+SGVGHETDFT+ADF Sbjct: 189 IKTASQRAECDVLIVCRGGGSIEDLWAFNEEPVVRAIESCTVPVVSGVGHETDFTLADFV 248 Query: 268 ADLRAPTPTAAAELAASARQDWLAELRGHAADLTRALRHTLADKAQSVDWLSRRLVSPSA 327 AD+RAPTPT AAEL + RQ+ L L L L D +Q +DWL+R++ P Sbjct: 249 ADMRAPTPTGAAELVSPNRQESLHRLAQAQCRLKTVLEQRYFDASQKLDWLARQIRHPRQ 308 Query: 328 YIQHERVKLLALQNRLSHANQIPLTRMRHGLQQLASRLAHQLPDTRHARRDLAELARRLQ 387 + +R + L LS++ M ++ +R Q +H R D++ + + Sbjct: 309 KLDEQRASIGKLAQTLSYS-------MTQNVRTHTARFERQTQALKHCRPDVSVCKKNID 361 Query: 388 RAQGAQQSA-------QRQTLTTLHSKLELLNPQRTLERGYAIVSDHQGRVLHSPAELAA 440 R Q A A +RQ+LT + LE ++PQ LERG+++V + +G+V+ + L Sbjct: 362 RFQTALSHAFHQLLTHRRQSLTAQAALLEAVSPQHILERGFSVVKNTRGQVIRNADVLKQ 421 Query: 441 RSEITIRLAQGSAEVGIASVQPRLD 465 ++ I A G +V ++ Q + D Sbjct: 422 GQKLHIIFADGETDVRVSKEQGQQD 446 >xseA [L] COG1570 Exonuclease VII, large subunit Eco Escherichia coli K12 Length = 456 Score = 335 bits (859), Expect = 1e-91, Method: Compositional matrix adjust. Identities = 189/442 (42%), Positives = 267/442 (60%), Gaps = 4/442 (0%) Query: 25 GPPMLTVSALNQAVGRMLERNFPLLWVKGEVSNFTRAASGHWYFNLKDEGAQVRAVMFKG 84 P + TVS LNQ V +LE +W+ GE+SNFT+ ASGHWYF LKD+ AQVR MF+ Sbjct: 6 SPAIFTVSRLNQTVRLLLEHEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRN 65 Query: 85 RAQYAGFMPREGDKVEVRTLVTLYAPRGDYQLNVEAIRRSGVGDLYAAFLQLKERLEREG 144 + F P+ G +V VR +TLY PRGDYQ+ VE+++ +G G L + QLK +L+ EG Sbjct: 66 SNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIVESMQPAGEGLLQQKYEQLKAKLQAEG 125 Query: 145 LFARERKRALPGFPRRIGIVTSPQAAALRDVLTTLRRRAPHVEVVLYPTPVQGEGAGQRI 204 LF ++ K+ LP +G++TS AAL D+L L+RR P + V++YP VQG+ A +I Sbjct: 126 LFDQQYKKPLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPAAVQGDDAPGQI 185 Query: 205 AAAIGRASERAECDVLLVCRGGGSIEDLWSFNEEVVARAIVATTMPVISGVGHETDFTIA 264 AI A++R ECDVL+V RGGGS+EDLWSFN+E VARAI + +PV+S VGHETD TIA Sbjct: 186 VRAIELANQRNECDVLIVGRGGGSLEDLWSFNDERVARAIFTSRIPVVSAVGHETDVTIA 245 Query: 265 DFAADLRAPTPTAAAELAASARQDWLAELRGHAADLTRALRHTLADKAQSVDWLSRRLVS 324 DF ADLRAPTP+AAAE+ + +Q+ L +++ L A+ + LA++ + + RL Sbjct: 246 DFVADLRAPTPSAAAEVVSRNQQELLRQVQSTRQRLEMAMDYYLANRTRRFTQIHHRLQQ 305 Query: 325 --PSAYIQHERVKLLALQNRLSHANQIPLTRMRHGLQQLASRLAHQLPDTR--HARRDLA 380 P + ++ L LQ R+S A + L R Q+L RL Q P + A+ + Sbjct: 306 QHPQLRLARQQTMLERLQKRMSFALENQLKRTGQQQQRLTQRLNQQNPQPKIHRAQTRIQ 365 Query: 381 ELARRLQRAQGAQQSAQRQTLTTLHSKLELLNPQRTLERGYAIVSDHQGRVLHSPAELAA 440 +L RL AQ SA R+ + LE ++P TL RGY++ + G VL ++ A Sbjct: 366 QLEYRLAETLRAQLSATRERFGNAVTHLEAVSPLSTLARGYSVTTATDGNVLKKVKQVKA 425 Query: 441 RSEITIRLAQGSAEVGIASVQP 462 +T RL G E + ++QP Sbjct: 426 GEMLTTRLEDGWIESEVKNIQP 447 >STM2512 [L] COG1570 Exonuclease VII, large subunit Sty Salmonella typhimurium LT2 Length = 449 Score = 332 bits (851), Expect = 1e-90, Method: Compositional matrix adjust. Identities = 184/439 (41%), Positives = 267/439 (60%), Gaps = 4/439 (0%) Query: 28 MLTVSALNQAVGRMLERNFPLLWVKGEVSNFTRAASGHWYFNLKDEGAQVRAVMFKGRAQ 87 + TVS LNQ V +LE+ +W+ GE+SNFT+ ASGHWYF LKD+ AQVR MF+ + Sbjct: 9 IFTVSRLNQTVRLLLEQEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNR 68 Query: 88 YAGFMPREGDKVEVRTLVTLYAPRGDYQLNVEAIRRSGVGDLYAAFLQLKERLEREGLFA 147 F P+ G +V VR +TLY PRGDYQ+ E+++ +G G L + QLK +L+ EGLF Sbjct: 69 RVTFRPQHGQQVLVRANITLYEPRGDYQIIAESMQPAGEGLLQQKYEQLKAKLQAEGLFD 128 Query: 148 RERKRALPGFPRRIGIVTSPQAAALRDVLTTLRRRAPHVEVVLYPTPVQGEGAGQRIAAA 207 ++ K+ LP +G++TS AAL D+L L+RR P + V++YPT VQG+ A +I A Sbjct: 129 QQHKQPLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPTAVQGDDAPGQIVRA 188 Query: 208 IGRASERAECDVLLVCRGGGSIEDLWSFNEEVVARAIVATTMPVISGVGHETDFTIADFA 267 I A+ R ECDVL+V RGGGS+EDLWSFN+E VARAI A+ +PV+S VGHETD TIADF Sbjct: 189 IELANARGECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPVVSAVGHETDVTIADFV 248 Query: 268 ADLRAPTPTAAAELAASARQDWLAELRGHAADLTRALRHTLADKAQSVDWLSRRLVS--P 325 ADLRAPTP+AAAE+ + +Q+ L +++ L A+ + LA++++ + RL P Sbjct: 249 ADLRAPTPSAAAEIVSRNQQELLRQIQSAQQRLGMAMDYYLANRSRRFTQIFHRLQQQHP 308 Query: 326 SAYIQHERVKLLALQNRLSHANQIPLTRMRHGLQQLASRLAHQLPDTR--HARRDLAELA 383 + ++ L L+ R+ A + + + Q ++ RL+ Q P R A+ + +L Sbjct: 309 QLRLARQQTALERLRQRMGFALEARIKQANQRQQCVSQRLSQQNPQPRIHRAQSRIQQLE 368 Query: 384 RRLQRAQGAQQSAQRQTLTTLHSKLELLNPQRTLERGYAIVSDHQGRVLHSPAELAARSE 443 RL ++ S QR+ + LE ++P TL RGY + + G+VL ++ A Sbjct: 369 YRLTENIRSRLSEQRERFGNAVTHLEAVSPLATLARGYTVSTTTDGKVLKKIKQVKAGDI 428 Query: 444 ITIRLAQGSAEVGIASVQP 462 +T RL G E + SV P Sbjct: 429 MTTRLEDGWLESEVKSVTP 447