BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0020.0123.p (318 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value STM2573 [H] COG1893 Ketopantoate reductase Sty Salmonella typhim... 176 8e-44 SPy0852 [H] COG1893 Ketopantoate reductase Spy Streptococcus pyo... 166 5e-41 L157055 [H] COG1893 Ketopantoate reductase Lla Lactococcus lactis 150 4e-36 CAC2937 [H] COG1893 Ketopantoate reductase Cac Clostridium aceto... 149 6e-36 SA2232 [H] COG1893 Ketopantoate reductase Sau Staphylococcus aur... 145 1e-34 >STM2573 [H] COG1893 Ketopantoate reductase Sty Salmonella typhimurium LT2 Length = 305 Score = 176 bits (445), Expect = 8e-44, Method: Compositional matrix adjust. Identities = 105/299 (35%), Positives = 155/299 (51%), Gaps = 2/299 (0%) Query: 1 MKIAIVGAGAMGGLFAARLALAGQDVSLIEVAPASIEAISSHGLSLTDEDGAHTVRVPVG 60 MKIAI GAGAMG F L AG DV+LI+ ++AI S GL + E +P Sbjct: 1 MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDGWQEHVDAIRSKGLFVETETTQKYYPIPAM 60 Query: 61 RADSFRDTFDLIILFTKGFHTQAAIASVAHLAGPHTWALSVQNGLGNADLIAEVIPRERI 120 AD + F+L+ILFTK + + + L + + NGLGN + + + + R++I Sbjct: 61 LADESQGEFELVILFTKAMQLDSMLQRIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKI 120 Query: 121 IVGMTNLPADLRAPGVVHSHGEGQVRVWTLSGQPSAQLTQVAADFNAAGLPCSADPLVQQ 180 G+T ++L G + + G G + + ++ Q SAQ +V A N+AGL P V Sbjct: 121 YAGVTLWSSELEGAGHIMATGTGTIELQPIASQDSAQEAKVIATLNSAGLNAEISPDVLL 180 Query: 181 AIWEKLAFNAALNAICAVTGLTVGAAGASASGRELALRIAAETVAVAQAAGIEARLVQVE 240 +IW+K AFN+ +N CA+ VG G +LA + E V VA + I V Sbjct: 181 SIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM 240 Query: 241 DAIEHAF--RTHLHHKPSMLQDIEAGRRTEIDFINGAVVREAERLGLPVPTTQTLHQLV 297 + ++ F R HH PSM QD+ GR TEID++NGA+ R + + VP + L QL+ Sbjct: 241 NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNKLLTQLI 299 >SPy0852 [H] COG1893 Ketopantoate reductase Spy Streptococcus pyogenes M1 GAS Length = 307 Score = 166 bits (421), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 107/310 (34%), Positives = 153/310 (49%), Gaps = 6/310 (1%) Query: 1 MKIAIVGAGAMGGLFAARLALAGQDVSLIEVAPASIEAISSHGLSLTDEDGAHTVRVPVG 60 M + I G+GAMG F +++ DV L++ I AI +GL +T D TV++P+ Sbjct: 1 MLVYIAGSGAMGCRFGYQISKTNNDVILLDNWEDHINAIKENGLVVTG-DVEETVKLPIM 59 Query: 61 RADSFRDTFDLIILFTKGFHTQAAIASVAHLAGPHTWALSVQNGLGNADLIAEVIPRERI 120 + DLIILFTK + + + G T L + NGLG+ D+I + IP I Sbjct: 60 KPTEATQEADLIILFTKAMQLPQMLQDIKGIIGKETKVLCLLNGLGHEDVIRQYIPEHNI 119 Query: 121 IVGMTNLPADLRAPGVVHSHGEGQVRVWTLSGQPSAQLT--QVAADFNAAGLPCSADPLV 178 ++G+T A L PG H G G + + ++ PS Q QVA N A L + D V Sbjct: 120 LMGVTVWTAGLEGPGRAHLQGVGALNLQSMD--PSNQEAGHQVADLLNEANLNATYDENV 177 Query: 179 QQAIWEKLAFNAALNAICAVTGLTVGAAGASASGRELALRIAAETVAVAQAAGIEARLVQ 238 IW K N +N+ CA+ T+G AS G ++ I E V V QA G+E + Sbjct: 178 VPNIWRKACVNGTMNSTCALLDCTIGELFASEDGLKMVKEIIHEFVIVGQAEGVELNEEE 237 Query: 239 VEDAIEHAFRTHLHHKPSMLQD-IEAGRRTEIDFINGAVVREAERLGLPVPTTQTLHQLV 297 + + HH PSM QD ++ R TEIDFINGAV + E+LG+ P + + +LV Sbjct: 238 ITQYVMDTSVKAAHHYPSMHQDLVQNHRLTEIDFINGAVNTKGEKLGINTPYCRMITELV 297 Query: 298 KLMEGAAQAQ 307 E Q Sbjct: 298 HAKEAVLNIQ 307 >L157055 [H] COG1893 Ketopantoate reductase Lla Lactococcus lactis Length = 312 Score = 150 bits (379), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 95/312 (30%), Positives = 146/312 (46%), Gaps = 5/312 (1%) Query: 1 MKIAIVGAGAMGGLFAARLALAGQDVSLIEVAPASIEAISSHGL--SLTDEDGAHTVRVP 58 M+I I GAGAMG F L G +V+LI+ P ++AI HGL + E+ + V Sbjct: 1 MRITIAGAGAMGSRFGLMLHKGGNEVTLIDGWPEHVKAIKEHGLRANYNGEELTAHLSVE 60 Query: 59 VGRADSFRDTFDLIILFTKGFHTQAAIASVAHLAGPHTWALSVQNGLGNADLIAEVIPRE 118 + S ++ DLIILFTK + + L HT L + NG+G+ D I + + + Sbjct: 61 LQSEISSKEKTDLIILFTKAMQLDKMLQDIKPLIDEHTKVLCLLNGIGHEDTIEKYVSKN 120 Query: 119 RIIVGMTNLPADLRAPGVVHSHGEGQVRVWTLSGQPSAQLTQVAADFNAAGLPCSADPLV 178 I +G T A L PG G+G V + L ++A + +GL + Sbjct: 121 NIFIGNTMWTAGLEGPGKAKLFGDGSVELQNLISGEEETAKKLAEILSESGLNAKYSNNI 180 Query: 179 QQAIWEKLAFNAALNAICAVTGLTVGAAGASASGRELALRIAAETVAVAQAAGIEARLVQ 238 +I+ K N +N +C + + G + ++ + I E AVA+ + + + Sbjct: 181 HYSIYRKACVNGTMNGLCTILDTNMAGLGETKPAHDMVVTIVNEFAAVAKFENVNLDIAE 240 Query: 239 VEDAIEHAF--RTHLHHKPSMLQD-IEAGRRTEIDFINGAVVREAERLGLPVPTTQTLHQ 295 V +E F T H PSM QD I+ R TEID+INGAV R+ ++ + P L Q Sbjct: 241 VVQHVETCFDPSTIGLHYPSMYQDLIKNNRLTEIDYINGAVSRKGKKYNVATPYCDFLTQ 300 Query: 296 LVKLMEGAAQAQ 307 LV E +A+ Sbjct: 301 LVHSKEELLKAK 312 >CAC2937 [H] COG1893 Ketopantoate reductase Cac Clostridium acetobutylicum Length = 307 Score = 149 bits (377), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 93/308 (30%), Positives = 153/308 (49%), Gaps = 11/308 (3%) Query: 1 MKIAIVGAGAMGGLFAARLALAGQDVSLIEVAPASIEAISSHGLSLTDEDGAHTVRVPVG 60 MK+A++GAGAMGGL+ A L+ DV +I++ +++I+ +GL + + + + V Sbjct: 1 MKVAVIGAGAMGGLYGAYLS-RKNDVYMIDINEKVVKSINENGLIIYERENNKKEKFLVS 59 Query: 61 RADSFRDT-----FDLIILFTKGFHTQAAIASVAHLAGPHTWALSVQNGLGNADLIAEVI 115 +F D+ DL+I+F K +T +A+ + +L T +++QNG GN + + I Sbjct: 60 ---AFTDSSNLGPMDLVIIFVKNLYTTSALKNNLNLFSDSTLVITLQNGAGNDRDLEKFI 116 Query: 116 PRERIIVGMTNLPADLRAPGVVHSHGEGQVRVWTLSGQPSAQLTQVAADFNAAGLPCSAD 175 +E I++G T + G V + EG + L + + +++ +F A L Sbjct: 117 KKENILIGTTEHSCSILETGEVSHNQEGITNIGMLVYNDNI-IKRISDEFKACSLKTEVY 175 Query: 176 PLVQQAIWEKLAFNAALNAICAVTGLTVGAAGASASGRELALRIAAETVAVAQAAGIEAR 235 +Q+ IW KL N ALN+ A+ VG S E+ I +E V VA A G Sbjct: 176 QNIQEIIWSKLFINMALNSTTAILNCKVGYLEKSKDASEIVQSILSEAVDVAIADGTFFN 235 Query: 236 LVQVEDAIEHAFRTHLHHK-PSMLQDIEAGRRTEIDFINGAVVREAERLGLPVPTTQTLH 294 +V D ++ R L + SM QD+ R TEID INGAV A+ +P P + Sbjct: 236 KKEVIDKVQKCIREDLPNAITSMNQDVSNKRLTEIDHINGAVANLAKLYKIPTPYNDCII 295 Query: 295 QLVKLMEG 302 ++ +EG Sbjct: 296 HIIHALEG 303 >SA2232 [H] COG1893 Ketopantoate reductase Sau Staphylococcus aureus N315 Length = 311 Score = 145 bits (365), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 94/313 (30%), Positives = 154/313 (49%), Gaps = 9/313 (2%) Query: 1 MKIAIVGAGAMGGLFAARLALAGQDVSLIEVAPASIEAISSHGLSLTDEDGAHTVRVPVG 60 MKIAI G+GA+G F A+L AG DV+LI+ + +EA+ HGL++T A + +P+ Sbjct: 1 MKIAIAGSGALGSGFGAKLFQAGYDVTLIDGYTSHVEAVKQHGLNITINGEAFELNIPMY 60 Query: 61 RADSFRD--TFDLIILFTKGFHTQAAIASVAHLAGPHTWALSVQNGLGNADLIAEVIPRE 118 + RD +D++ LF K + + + T + NGL + ++IA+ + + Sbjct: 61 HFNDQRDESIYDVVFLFPKSMQLKEVMEDMKPHIDNETIVVCTMNGLKHEEVIAQYVAQS 120 Query: 119 RIIVGMTNLPADLRAPGVVHSHGEGQVRVWTLSGQPSAQLTQVAADFNAAGLPCSADPLV 178 +I+ G+T A L +PG H G G V + L + + +VA N A L + Sbjct: 121 QIVRGVTTWTAGLESPGHSHLLGSGPVEIGELVDEGKENVIKVADLLNEAELNGVISKDL 180 Query: 179 QQAIWEKLAFNAALNAICAVTGLTVGAAGASASGRELALRIAAETVAVAQAAGIEARLVQ 238 Q+IW+K+ N NA+ V + + S+ + L ++ E V VA + + Sbjct: 181 YQSIWKKICVNGTANALSTVLECNMASLNESSYAKCLIYKLTQEIVHVATIDNVH---LN 237 Query: 239 VEDAIEHAFRTHLH---HKPSMLQD-IEAGRRTEIDFINGAVVREAERLGLPVPTTQTLH 294 V++A E+ + H PSM QD I R+TEID+INGAV ++ + P + + Sbjct: 238 VDEAFEYLVDLNEKVGAHYPSMYQDLIVNNRKTEIDYINGAVATLGKQRHIEAPVNRFIT 297 Query: 295 QLVKLMEGAAQAQ 307 L+ E AQ Sbjct: 298 DLIHTKESQRHAQ 310