BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0020.0119.p (442 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2214 [GEPR] COG0477 Permeases of the major facilitator superfa... 317 4e-86 Cj0484 [GEPR] COG0477 Permeases of the major facilitator superfa... 314 2e-85 RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 300 4e-81 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 299 7e-81 RSp1572 [GEPR] COG0477 Permeases of the major facilitator superf... 298 2e-80 >PA2214 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 440 Score = 317 bits (811), Expect = 4e-86, Method: Compositional matrix adjust. Identities = 180/421 (42%), Positives = 250/421 (59%), Gaps = 13/421 (3%) Query: 18 VLQQAVAKIKQRVLPLFVIMFIVNYIDRVNIGFVRSHLATDVGIGTAAYGLGAGLFFVGY 77 +L A+A + R+LP V+M+++ +IDR N+G+ R+ L D G+G AA+ GA +FF+GY Sbjct: 10 LLSSAIATSRLRLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGY 69 Query: 78 ALFEVPSNLLLQRFGAKAWLTRIMATWGLAATAMAFVNSETTFYVLRFLLGAAEAGFFPG 137 A FEVPSNL+L R GA+ WL RIM TWGL + AM F + TFYVLRFLLG AEAGFFPG Sbjct: 70 ACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMFADDAMTFYVLRFLLGVAEAGFFPG 129 Query: 138 VIYYFTQWLPASERGRAMAIFLSGSALASILSGPISGGLLQIDG-GGLHGWQWMFIIEGM 196 +I Y T W P R +A+ +F G LA +L GP+SG LL+ G GL WQW+F+ EG+ Sbjct: 130 IILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGIFGLANWQWLFVTEGL 189 Query: 197 ASVLLCGFVWFWLDSMPADAKWLTAQERSAITSAIVDEQAERMKHQPAQVSPRQLLRDPQ 256 + L+ +F+L P DA WL+ +++ A+ + +E + P LR Q Sbjct: 190 LASLVGIAAYFYLVDRPRDAGWLSDEQKRALEGELAEEDTRKQARGPHGF--LSALRSGQ 247 Query: 257 ILIFCFIYFSISLTIYGATFWLPSIIRKMGSFSDFQ----VGLFNSIPWLISIVAMYAFA 312 +L FC +YF+I +++YG F+LP+ ++ SF D Q VGL +IPW+ ++V Sbjct: 248 VLKFCLVYFTIQMSVYGVVFYLPT---RIASFLDGQVGLNVGLITAIPWVCALVVTRLVT 304 Query: 313 ALAARF-KHQQAWAATALVIAAAGMFASTFGNSVYAFVSICFAAVGFKAASSLFWPLPQA 371 A R +H+Q A + AA ++ GN A ++ CFAA GF + LFW LP Sbjct: 305 RQADRSGQHRQLAVAMLGMAAAGIAASALAGNLGLAVIAFCFAASGFVSVQPLFWTLPTG 364 Query: 372 YLDARIAAGVIALINSIGNLGGFVAPTAFGFLEQRTGSIQGGLMGLAITSLVAAGVVFLA 431 YL AA IALINS+GNLGGFVAP +E + + G+ LA L+ G LA Sbjct: 365 YLSGAAAASGIALINSLGNLGGFVAPNLKTLMESQFADPRAGMFALAAVGLL--GACLLA 422 Query: 432 R 432 R Sbjct: 423 R 423 >Cj0484 [GEPR] COG0477 Permeases of the major facilitator superfamily Cje Campylobacter jejuni Length = 410 Score = 314 bits (805), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 179/408 (43%), Positives = 248/408 (60%), Gaps = 9/408 (2%) Query: 19 LQQAVAKIKQRVLPLFVIMFIVNYIDRVNIGFVRSHLATDVGIGTAAYGLGAGLFFVGYA 78 L+ KI R+LPL V+MF ++ +DR NI FV+SH+ D GIG AAY LGAG+FF+GYA Sbjct: 9 LELVCKKISWRILPLIVLMFCLSMLDRTNISFVKSHIEIDAGIGEAAYALGAGIFFIGYA 68 Query: 79 LFEVPSNLLLQRFGAKAWLTRIMATWGLAATAMAFVNSETTFYVLRFLLGAAEAGFFPGV 138 +FEVPSNL L + GAK WL+RIM TWGL AM F+ E +FYVLRFLLG EAGF PG+ Sbjct: 69 IFEVPSNLFLHKLGAKIWLSRIMITWGLVTMAMIFIQGEISFYVLRFLLGLTEAGFSPGI 128 Query: 139 IYYFTQWLPASERGRAMAIFLSGSALASILSGPISGGLLQIDGG-GLHGWQWMFIIEGMA 197 I Y + + PA R +A I+ G +A + ISG +L WQWMF+IEG Sbjct: 129 ILYLSYFFPAIYRSKAYGIYQMGVPIAFVFGSLISGFILDYTPNIYFKNWQWMFLIEGGI 188 Query: 198 SVLLCGFVWFWLDSMPADAKWLTAQERSAITSAIVDEQAERMKHQPAQVSPRQLLRDPQI 257 +VL+ F F+LDS P DAKWL +E+ I+ + E + S + + + + Sbjct: 189 TVLVGIFCLFYLDSHPKDAKWLDIKEKD-----ILLKHIEISNTKAKDYSIKDIFKSILV 243 Query: 258 LIFCFIYFSISLTIYGATFWLPSIIRKMGSFS-DFQVGLFNSIPWLISIVAMYAFAALAA 316 F F+YF I L++YG F+LPS I ++ + F+VGL N+IPW+ +A+ F +LA Sbjct: 244 WKFVFVYFCIQLSVYGVLFYLPSKIAQILQINVGFEVGLLNAIPWIFVFIALPIFTSLAD 303 Query: 317 RFKHQQAWAATALVIAAAGMFASTFGNSVYAFV-SICFAAVGFKAASSLFWPLPQAYLDA 375 + A L++A+ M ASTF ++ AF+ I AA+GF +FW LP L Sbjct: 304 KKHSWNLHAILFLLLASLSMIASTFVTNLAAFLFFISLAAIGFIVIQPIFWNLPTQVLKG 363 Query: 376 RIAAGVIALINSIGNLGGFVAPTAFGFLEQRTGSIQGGLMGLAITSLV 423 + AA IALI S+GNLGGFVAPT ++E G ++ GL+ LA+ +++ Sbjct: 364 KGAAAAIALIGSLGNLGGFVAPTLKTYIENHFG-VEFGLIVLALIAIL 410 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 300 bits (769), Expect = 4e-81, Method: Compositional matrix adjust. Identities = 171/425 (40%), Positives = 255/425 (60%), Gaps = 10/425 (2%) Query: 6 PAASATGAAAPTVLQQAV-AKIKQRVLPLFVIMFIVNYIDRVNIGFVRSHLATDVGIGTA 64 P+A A + + ++A K+ R++P ++ ++V Y+DRVN+GF + + D+ Sbjct: 10 PSAGALPPQSASGFEEATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDLKFSET 69 Query: 65 AYGLGAGLFFVGYALFEVPSNLLLQRFGAKAWLTRIMATWGLAATAMAFVNSETTFYVLR 124 YGLGAG+FF+GY LFEVPSN++L R GA+ W+ RIM +WGL + AM FV + FYV+R Sbjct: 70 VYGLGAGIFFIGYFLFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAMFYVMR 129 Query: 125 FLLGAAEAGFFPGVIYYFTQWLPASERGRAMAIFLSGSALASILSGPISGGLLQIDGG-- 182 FLLG AEAGFFPG+I Y T W PA RGR F++ AL+ ++ GPISG L+ GG Sbjct: 130 FLLGLAEAGFFPGIILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGGVY 189 Query: 183 GLHGWQWMFIIEGMASVLLCGFVWFWLDSMPADAKWLTAQERSAITSAIVDEQAERMKHQ 242 GL GWQWMF+IEG+ SV++ V +LD+ + A+WLT +E++ +T I E+A++ Sbjct: 190 GLAGWQWMFLIEGIPSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEEAQKEDAP 249 Query: 243 PAQVSPRQLLRDPQILIFCFIYFSISLTIYGATFWLPSIIRKMGSFSDFQVGLFNSIPWL 302 A + + P++ + IYFS + +YG +FWLP++I++ G VGL +IP+ Sbjct: 250 IAAI-----MASPRVWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYG 304 Query: 303 ISIVAMYAFAALAARFKHQQAWAATALVIAAAGMFAST--FGNSVYAFVSICFAAVGFKA 360 ++VAM A A R + ++ A + A G+ S N+ A ++ +G Sbjct: 305 AAVVAMVLVARSADRTRERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGILT 364 Query: 361 ASSLFWPLPQAYLDARIAAGVIALINSIGNLGGFVAPTAFGFLEQRTGSIQGGLMGLAIT 420 LFW LP A+L AA IALINS+GNL GF++P A G+L+ T S G+ LA + Sbjct: 365 TLPLFWSLPTAFLAGTGAAAGIALINSLGNLAGFLSPYAVGWLKDTTRSTDSGMYLLAAS 424 Query: 421 SLVAA 425 ++ A Sbjct: 425 MVLGA 429 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 299 bits (766), Expect = 7e-81, Method: Compositional matrix adjust. Identities = 167/425 (39%), Positives = 255/425 (60%), Gaps = 8/425 (1%) Query: 9 SATGAAAPTVLQQAV-AKIKQRVLPLFVIMFIVNYIDRVNIGFVRSHLATDVGIGTAAYG 67 S T +P V++ K+ R++PL +I +I+ Y+DRVN+GF + ++ ++G A YG Sbjct: 22 SNTAITSPEVVENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEELGFSEAIYG 81 Query: 68 LGAGLFFVGYALFEVPSNLLLQRFGAKAWLTRIMATWGLAATAMAFVNSETTFYVLRFLL 127 LGAGLFF+GY FE+PSN+LL + GA+ W+ RIM TWGL + AFV +E FY+LRFLL Sbjct: 82 LGAGLFFIGYFFFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTEWQFYILRFLL 141 Query: 128 GAAEAGFFPGVIYYFTQWLPASERGRAMAIFLSGSALASILSGPISGGLLQ--IDGGGLH 185 GAAEAGF+PGVI Y T W P+ RG A+F +GS A I P+SG ++ D G Sbjct: 142 GAAEAGFYPGVILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAGWQ 201 Query: 186 GWQWMFIIEGMASVLLCGFVWFWLDSMPADAKWLTAQERSAITSAIVDEQAERMKHQPAQ 245 GWQWMF++E + +V+L + +LD+ AKWLT +E++ I+ D +A+ K + A Sbjct: 202 GWQWMFVLEAIPAVVLGVVILLYLDNSVKAAKWLTEEEKAIISR---DIEADS-KGKAAS 257 Query: 246 VSPRQLLRDPQILIFCFIYFSISLTIYGATFWLPSIIRKMGSFSDFQVGLFNSIPWLISI 305 S L+++P + + IYF + +G T W+P++IR G S+ +GL +IP++ +I Sbjct: 258 HSLMSLVKNPMLWVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICAI 317 Query: 306 VAMYAFAALAARFKHQQAWAATALVIAAAG-MFASTFGNSVYAFVSICFAAVGFKAASSL 364 +AM F+ A ++ ++ ++ A G + A++ N+ + + + AA G A + L Sbjct: 318 IAMVIFSRSADHYRERRWHLVVPALLGAVGFVVAASATNTTVSIIFLSMAAAGVLACAPL 377 Query: 365 FWPLPQAYLDARIAAGVIALINSIGNLGGFVAPTAFGFLEQRTGSIQGGLMGLAITSLVA 424 FW LP A L AA IALINS+ NL GF++P G + T S + G+ LA ++ Sbjct: 378 FWSLPTAILSGAAAAAGIALINSVANLAGFISPYMVGIIRDATHSSELGMYVLAGFLILG 437 Query: 425 AGVVF 429 A +V Sbjct: 438 AAIVL 442 >RSp1572 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 433 Score = 298 bits (762), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 168/412 (40%), Positives = 240/412 (58%), Gaps = 15/412 (3%) Query: 6 PAASATGAAAPTVLQQAVAKIKQRVLPLFVIMFIVNYIDRVNIGFVRSHLATDVGIGTAA 65 PA + +G + +V + + +R+LP ++ Y+DR+NIGF + + D+ + AA Sbjct: 7 PAQAHSGERSTSV----YSVVNRRILPFLATCYLFAYLDRINIGFAKLQMQNDLALSDAA 62 Query: 66 YGLGAGLFFVGYALFEVPSNLLLQRFGAKAWLTRIMATWGLAATAMAFVNSETTFYVLRF 125 YGLGAG+FF GY LFEVPSNLLL + GA+ L+RI+ WG+ + +M FV TFY LRF Sbjct: 63 YGLGAGIFFFGYMLFEVPSNLLLVKIGARRTLSRILILWGIVSASMLFVTDVWTFYALRF 122 Query: 126 LLGAAEAGFFPGVIYYFTQWLPASERGRAMAIFLSGSALASILSGPISGGLLQ--IDGGG 183 LLG EAGF PG+IYY TQW P RAMA+ L + L ++ GP S ++ GG Sbjct: 123 LLGVFEAGFAPGMIYYLTQWYPGERMARAMAVVLGAAPLGGVIGGPASTWIMGHFAGAGG 182 Query: 184 LHGWQWMFIIEGMASVLLCGFVWFWLDSMPADAKWLTAQERSAITSAIVDEQAERMKHQP 243 L GWQWMF+ EG+ S+LL + +L PADA+WLT +++ I I + P Sbjct: 183 LAGWQWMFLAEGIPSILLGIAAYGYLVDKPADARWLTDAQKAVIAGDIA-------RAAP 235 Query: 244 AQVSP-RQLLRDPQILIFCFIYFSISLTIYGATFWLPSIIRKMGSFSDFQVGLFNSIPWL 302 Q S + L +P++ + YF + +Y FWLPSI++ G FQ+GL+++IP L Sbjct: 236 GQASSFGKALTEPKLYVLAAAYFCLICGVYAVGFWLPSILKSAGLSDLFQIGLYSAIPNL 295 Query: 303 ISIVAMYAFAALAARFKHQQAWAATALVIAAAGMFASTFGNSV-YAFVSICFAAVGFKAA 361 IVAMYA + R + +A V+ A + + + S A +SI A+ A+ Sbjct: 296 AMIVAMYALGRRSDRRGERHLHSAITAVLGAGLLAWAAYATSFPAALISITLASAAIFAS 355 Query: 362 SSLFWPLPQAYLDARIAAGVIALINSIGNLGGFVAPTAFGFLEQRTGSIQGG 413 S+FW +PQ +L AAG IALINSIG GGF +PT G+ ++ TGS+Q G Sbjct: 356 YSVFWAIPQQHLKGTAAAGGIALINSIGLFGGFFSPTLIGWTKEATGSLQAG 407