BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0018.0397.p (524 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1292 [GEPR] COG0477 Permeases of the major facilitator superf... 666 0.0 STM2815 [GEPR] COG0477 Permeases of the major facilitator superf... 521 e-147 NMA2168 [GEPR] COG0477 Permeases of the major facilitator superf... 521 e-147 NMB0319 [GEPR] COG0477 Permeases of the major facilitator superf... 517 e-146 YPO3268 [GEPR] COG0477 Permeases of the major facilitator superf... 515 e-146 >RSc1292 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 518 Score = 666 bits (1718), Expect = 0.0, Method: Compositional matrix adjust. Identities = 325/512 (63%), Positives = 411/512 (80%), Gaps = 1/512 (0%) Query: 13 PPPPLTGANLVLGTLSVSLAVFMNVLDSSIANVAIPTISGNLGVSVDEGTWVITSFAAAN 72 P PLTGA L +GT+++SLA FMNVLDSSIANV+IP ISG+LGV+ ++GTWVITSFA AN Sbjct: 8 PLQPLTGAKLAIGTVALSLATFMNVLDSSIANVSIPAISGDLGVAPNQGTWVITSFAVAN 67 Query: 73 AISIPLTGWLTQRLGAVRLFVTSVLLFVLASWLCGLAPTLPILLAARVLQGLVAGPMVPL 132 AIS+PLTGWLTQR G VRLFVTS+LLFVL+SW CGLAP + L+AAR+LQG VAGPM+PL Sbjct: 68 AISVPLTGWLTQRFGQVRLFVTSILLFVLSSWACGLAPNMGTLIAARILQGAVAGPMIPL 127 Query: 133 SQSLLLGAYPKSKSSFALALWGMTAVVAPVAGPALGGWITDSYTWPWIFYINIPVGLIAA 192 SQSLLL YP +KSS ALALWGMT +VAP+ GP GGWI+D+ TWPWIFYINIPVG++AA Sbjct: 128 SQSLLLSTYPPAKSSMALALWGMTTLVAPIMGPIFGGWISDNMTWPWIFYINIPVGILAA 187 Query: 193 GVTLAIYRSRETPTHKLPIDKIGLALLVTWVAAFQIMLDKGKDLDWFASPTIVTLGIIAL 252 T IY+ RE+PT LPID+IGLALLV WV + Q+MLD+GK+LDWF S IVTL ++A+ Sbjct: 188 YATWVIYKDRESPTRALPIDRIGLALLVIWVGSLQLMLDRGKELDWFNSAEIVTLTVVAV 247 Query: 253 IAFAYFVVWELNNDHPVVDLRLFGRRNFAGGTIAISIGYGVFFGNLVILPQWLQQYLGYR 312 + FA+F+VWEL DHPVVDL LF RNF+ G +AIS+ YG+FFGNLVILP WLQ +GY Sbjct: 248 VGFAFFLVWELTEDHPVVDLTLFKGRNFSAGVVAISVAYGLFFGNLVILPLWLQTIVGYT 307 Query: 313 SIDSGLSTAPIGIFAVILMPLIGRFLPLVDARKVATASFIGFAIVFWLRSRYNLQVDQMT 372 + D+GL AP+GIFA++L P+IG+ LP +DAR VAT +FI FA+VFW+RSR+ +QVD T Sbjct: 308 ATDAGLVMAPVGIFAILLSPVIGKNLPKMDARWVATTAFITFALVFWMRSRFTIQVDTWT 367 Query: 373 VILPTLLQGIPTAMFFVPLTVLLLSGLPPERIPAAAGLSSFVRVFCGAVGTSISTTAWNN 432 +++PTL+QG AMFF+PLT ++LSGL PERIPAA+GLS+FVR+ G +G SISTT W+N Sbjct: 368 LMVPTLIQGAAMAMFFIPLTSIILSGLRPERIPAASGLSNFVRIMFGGIGASISTTVWDN 427 Query: 433 RSIMHHAQLTEHATPYSPWLQETVNNLSSTLGLNAEQTAGMLERTITFQAAMLGINDIFY 492 RS +HHAQL E A PY+P ++ + + +G+ + Q G +ER I+ QAAM+G NDIF+ Sbjct: 428 RSALHHAQLVERANPYNPAYASSLGDYTQ-MGMPSLQANGAIERIISQQAAMMGANDIFW 486 Query: 493 VSAVIFIVIIPLIWIIKPSKGGAGAAEASAAH 524 +SAV+FIV+I LIW+ +P+K GA A+ AH Sbjct: 487 ISAVLFIVLIALIWLTRPAKSAGGAEAAAGAH 518 >STM2815 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 512 Score = 521 bits (1342), Expect = e-147, Method: Compositional matrix adjust. Identities = 258/496 (52%), Positives = 355/496 (71%), Gaps = 2/496 (0%) Query: 16 PLTGANLVLGTLSVSLAVFMNVLDSSIANVAIPTISGNLGVSVDEGTWVITSFAAANAIS 75 PL GA LV+ T+++SLA FM VLDS+IANVAIPTI+GNLG S+ +GTWVITSF ANAIS Sbjct: 6 PLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAIS 65 Query: 76 IPLTGWLTQRLGAVRLFVTSVLLFVLASWLCGLAPTLPILLAARVLQGLVAGPMVPLSQS 135 IPLTGWL +R G V+LF+ S + F ASW CG++ +L +L+ RV+QG+VAGP++PLSQS Sbjct: 66 IPLTGWLAKRFGEVKLFMWSTVAFAAASWACGVSSSLNMLIFFRVVQGVVAGPLIPLSQS 125 Query: 136 LLLGAYPKSKSSFALALWGMTAVVAPVAGPALGGWITDSYTWPWIFYINIPVGLIAAGVT 195 LLL YP +K S ALALW MT +VAP+ GP LGG+I+D+Y W WIF+IN+P+G+ +T Sbjct: 126 LLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGIAVVLMT 185 Query: 196 LAIYRSRETPTHKLPIDKIGLALLVTWVAAFQIMLDKGKDLDWFASPTIVTLGIIALIAF 255 L R RET T + ID +GLALLV + + QIMLD+GK+LDWF+S I+ L ++A+IA Sbjct: 186 LHTLRGRETHTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVIAI 245 Query: 256 AYFVVWELNNDHPVVDLRLFGRRNFAGGTIAISIGYGVFFGNLVILPQWLQQYLGYRSID 315 ++ +VWEL +DHP+VDL LF RNF G + IS+ Y ++FG +V+LPQ LQ+ GY + Sbjct: 246 SFLIVWELTDDHPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATW 305 Query: 316 SGLSTAPIGIFAVILMPLIGRFLPLVDARKVATASFIGFAIVFWLRS-RYNLQVDQMTVI 374 +GL++AP+GI VIL P+IGRF +D R++ T SFI +A+ F+ R+ + +D Sbjct: 306 AGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAWTFEPGMDFGASA 365 Query: 375 LPTLLQGIPTAMFFVPLTVLLLSGLPPERIPAAAGLSSFVRVFCGAVGTSISTTAWNNRS 434 P +QG A FF+PLT + LSGLPPER+ AA+ LS+F R G++GTSI+TT W +R Sbjct: 366 WPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWTDRE 425 Query: 435 IMHHAQLTEHATPYSPWLQETVNNLSSTLGLNAEQTAGMLERTITFQAAMLGINDIFYVS 494 +HHAQLTE T Y+P Q + L LG+ +Q +G + + IT Q ++ N+IF++S Sbjct: 426 SLHHAQLTESVTAYNPNAQTMYDKLEG-LGMTHQQASGWIAQQITNQGLIISANEIFWMS 484 Query: 495 AVIFIVIIPLIWIIKP 510 A IF+V++ L+W KP Sbjct: 485 AGIFLVLLGLVWFAKP 500 >NMA2168 [GEPR] COG0477 Permeases of the major facilitator superfamily NmA Neisseria meningitidis Z2491 Length = 516 Score = 521 bits (1341), Expect = e-147, Method: Compositional matrix adjust. Identities = 262/515 (50%), Positives = 355/515 (68%), Gaps = 3/515 (0%) Query: 5 PTPSQAYTPPPPLTGANLVLGTLSVSLAVFMNVLDSSIANVAIPTISGNLGVSVDEGTWV 64 P+ ++ PPL GA L TLS+ LAVFM VLD++IANVA+P I+GNLG + +GTWV Sbjct: 2 PSETEDTMDYPPLKGAALAWVTLSLGLAVFMEVLDTTIANVAVPVIAGNLGAATTQGTWV 61 Query: 65 ITSFAAANAISIPLTGWLTQRLGAVRLFVTSVLLFVLASWLCGLAPTLPILLAARVLQGL 124 ITSFA ANA+S+PLTG+L +R+G V+LF + + FV+ SWLCG+AP L L+ R+LQG Sbjct: 62 ITSFAVANAVSVPLTGFLAKRIGEVKLFTAAAVGFVITSWLCGIAPNLQSLVVFRILQGF 121 Query: 125 VAGPMVPLSQSLLLGAYPKSKSSFALALWGMTAVVAPVAGPALGGWITDSYTWPWIFYIN 184 +AGP++PLSQSLL+ +YP +K + ALALW MT VVAPV GP LGGWI+ ++ W WIF+IN Sbjct: 122 IAGPLIPLSQSLLMASYPPAKRTLALALWAMTVVVAPVLGPILGGWISGNWHWGWIFFIN 181 Query: 185 IPVGLIAAGVTLAIYRSRETPTHKLPIDKIGLALLVTWVAAFQIMLDKGKDLDWFASPTI 244 IP+G+I+A +T + RET T K+P D +GL L+V + A Q+MLD+GK+LDWFAS I Sbjct: 182 IPIGIISAWITWKHLKCRETETVKMPTDYVGLTLMVVGIGALQMMLDRGKELDWFASGEI 241 Query: 245 VTLGIIALIAFAYFVVWELNNDHPVVDLRLFGRRNFAGGTIAISIGYGVFFGNLVILPQW 304 +TLG++AL+ +YF+VWEL +P+VDL LF RNF G IA S+G+ V+ G L +LP Sbjct: 242 ITLGVVALVCLSYFIVWELGEKYPIVDLSLFKDRNFTVGIIATSLGFMVYMGTLTLLPLV 301 Query: 305 LQQYLGYRSIDSGLSTAPIGIFAVILMPLIGRFLPLVDARKVATASFIGFAIVFWLRSRY 364 LQ LGY S +GL+ AP+GI V L PLIGRF +D R + TASF+ FA F+ R+ + Sbjct: 302 LQTNLGYTSTWAGLAAAPVGILPVFLSPLIGRFGNKIDMRLLVTASFLTFAFTFYWRTDF 361 Query: 365 NLQVDQMTVILPTLLQGIPTAMFFVPLTVLLLSGLPPERIPAAAGLSSFVRVFCGAVGTS 424 +D VI P QG+ AMFF+PLT + LS + +I AA LS+F+RV G VG S Sbjct: 362 YADMDIGNVIWPQFWQGVGVAMFFLPLTTITLSHMKGGQIAAAGSLSNFLRVLMGGVGVS 421 Query: 425 ISTTAWNNRSIMHHAQLTEHATPYSPWLQETVNNLSSTLGLNAEQTAGMLERTITFQAAM 484 + +T W R +HH + EH TPYS L ET +LS G++ QT G++ TIT Q + Sbjct: 422 VVSTLWERREALHHTRFAEHITPYSATLHETAAHLSQH-GVSDIQTLGIINNTITQQGFI 480 Query: 485 LGINDIFYVSAVIFIVIIPLIWIIKP--SKGGAGA 517 +G N+IF +++FI++IP+IW+ KP GG G Sbjct: 481 IGSNEIFMAGSLLFIIMIPVIWLAKPPFHNGGGGG 515 >NMB0319 [GEPR] COG0477 Permeases of the major facilitator superfamily Nme Neisseria meningitidis MC58 Length = 508 Score = 517 bits (1331), Expect = e-146, Method: Compositional matrix adjust. Identities = 260/505 (51%), Positives = 350/505 (69%), Gaps = 3/505 (0%) Query: 15 PPLTGANLVLGTLSVSLAVFMNVLDSSIANVAIPTISGNLGVSVDEGTWVITSFAAANAI 74 PPL GA L TLS+ LAVFM VLD++IANVA+P I+GNLG + +GTWVITSF+ ANA+ Sbjct: 4 PPLKGAALAWVTLSLGLAVFMEVLDTTIANVAVPVIAGNLGAATTQGTWVITSFSVANAV 63 Query: 75 SIPLTGWLTQRLGAVRLFVTSVLLFVLASWLCGLAPTLPILLAARVLQGLVAGPMVPLSQ 134 S+PLTG+L +R+G V+LF + + FV+ SWLCG+AP L L+ R+LQG +AGP++PLSQ Sbjct: 64 SVPLTGFLAKRIGEVKLFTAAAVGFVITSWLCGIAPNLQSLVVFRILQGFIAGPLIPLSQ 123 Query: 135 SLLLGAYPKSKSSFALALWGMTAVVAPVAGPALGGWITDSYTWPWIFYINIPVGLIAAGV 194 SLL+ +YP +K + ALALW MT VVAPV GP LGGWI+ ++ W WIF+INIP+G+I+A + Sbjct: 124 SLLMASYPPAKRTLALALWAMTVVVAPVLGPILGGWISGNWHWGWIFFINIPIGIISAWI 183 Query: 195 TLAIYRSRETPTHKLPIDKIGLALLVTWVAAFQIMLDKGKDLDWFASPTIVTLGIIALIA 254 T + RET T K+P D +GL L+V + A Q+MLD+GK+LDWFAS I+TLG++AL+ Sbjct: 184 TWKHLKYRETETVKMPTDYVGLTLMVVGIGALQMMLDRGKELDWFASGEIITLGVVALVC 243 Query: 255 FAYFVVWELNNDHPVVDLRLFGRRNFAGGTIAISIGYGVFFGNLVILPQWLQQYLGYRSI 314 +YF+VWEL +P+VDL LF RNF G IA S+G+ V+ G L +LP LQ LGY S Sbjct: 244 LSYFIVWELGEKYPIVDLSLFKDRNFTVGVIATSLGFMVYMGTLTLLPLVLQTNLGYTST 303 Query: 315 DSGLSTAPIGIFAVILMPLIGRFLPLVDARKVATASFIGFAIVFWLRSRYNLQVDQMTVI 374 +GL+ AP+GI V L PLIGRF +D R TASF+ FA F+ R+ + +D VI Sbjct: 304 WAGLAAAPVGILPVFLSPLIGRFGNKIDMRLFVTASFLTFAFTFYWRTDFYADMDIGNVI 363 Query: 375 LPTLLQGIPTAMFFVPLTVLLLSGLPPERIPAAAGLSSFVRVFCGAVGTSISTTAWNNRS 434 P QG+ AMFF+PLT + LS + +I AA LS+F+RV G VG S+ +T W R Sbjct: 364 WPQFWQGVGVAMFFLPLTTITLSHMKGGQIAAAGSLSNFLRVLMGGVGVSVVSTLWERRE 423 Query: 435 IMHHAQLTEHATPYSPWLQETVNNLSSTLGLNAEQTAGMLERTITFQAAMLGINDIFYVS 494 +HH + EH TPYS L ET +LS G++ QT G++ TIT Q ++G N+IF Sbjct: 424 ALHHTRFAEHITPYSATLHETAAHLSQH-GVSDIQTLGIINNTITQQGFIIGSNEIFMAG 482 Query: 495 AVIFIVIIPLIWIIKP--SKGGAGA 517 +++FI++IP+IW+ KP GG G Sbjct: 483 SLLFIIMIPVIWLAKPPFHNGGGGG 507 >YPO3268 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 511 Score = 515 bits (1327), Expect = e-146, Method: Compositional matrix adjust. Identities = 260/497 (52%), Positives = 352/497 (70%), Gaps = 4/497 (0%) Query: 16 PLTGANLVLGTLSVSLAVFMNVLDSSIANVAIPTISGNLGVSVDEGTWVITSFAAANAIS 75 PL GA L T+++SLA FM VLDS+IANVAIPTI+G+LG S +GTWVITSF ANAIS Sbjct: 5 PLEGAPLAWMTVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAIS 64 Query: 76 IPLTGWLTQRLGAVRLFVTSVLLFVLASWLCGLAPTLPILLAARVLQGLVAGPMVPLSQS 135 IP+TGWL +R+G VRLF+ S LFVLASWLCG++ +L +L+ RV+QGLVAGP++PLSQS Sbjct: 65 IPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQS 124 Query: 136 LLLGAYPKSKSSFALALWGMTAVVAPVAGPALGGWITDSYTWPWIFYINIPVGLIAAGVT 195 LLL YP +K S ALALW MT VVAP+ GP LGG+I+D+Y W WIF+INIP+GL+ + Sbjct: 125 LLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLA 184 Query: 196 LAIYRSRETPTHKLPIDKIGLALLVTWVAAFQIMLDKGKDLDWFASPTIVTLGIIALIAF 255 + + RET T PID IGL LLV + A QIMLD+GK+LDWF S I+ L ++A++A Sbjct: 185 GSTLKGRETKTEIRPIDTIGLVLLVVGIGALQIMLDQGKELDWFNSTEIIVLTVVAVVAI 244 Query: 256 AYFVVWELNNDHPVVDLRLFGRRNFAGGTIAISIGYGVFFGNLVILPQWLQQYLGYRSID 315 + +VWEL +DHPV+DL LF RNF G + +S+ Y ++FG +V+LPQ LQ+ GY + Sbjct: 245 TFLIVWELTDDHPVIDLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATW 304 Query: 316 SGLSTAPIGIFAVILMPLIGRFLPLVDARKVATASFIGFAIVFWLRSRYNLQ--VDQMTV 373 +GL++AP+GI V+L PLIGRF +D R++ T SFI +A+ F+ R+ Y + +D Sbjct: 305 AGLASAPVGILPVLLSPLIGRFAHRIDMRQLVTFSFIMYAVCFYWRA-YTFEPGMDFGAS 363 Query: 374 ILPTLLQGIPTAMFFVPLTVLLLSGLPPERIPAAAGLSSFVRVFCGAVGTSISTTAWNNR 433 P QG A FF+PLT + LSGLPPER+ AA+ LS+F+R G++GTSI+TT W R Sbjct: 364 AWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSITTTLWTQR 423 Query: 434 SIMHHAQLTEHATPYSPWLQETVNNLSSTLGLNAEQTAGMLERTITFQAAMLGINDIFYV 493 +HHAQLTE PY+P + L LG++ +Q + L R IT Q ++ N+IF++ Sbjct: 424 ESLHHAQLTEFVNPYNPNATQAYQELEK-LGMSQQQASAYLAREITNQGLIISANEIFWL 482 Query: 494 SAVIFIVIIPLIWIIKP 510 SA +F++++ LIW +P Sbjct: 483 SAGVFLMLLALIWFARP 499