BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0018.0281.p (214 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1784 [F] COG0125 Thymidylate kinase Rso Ralstonia solanacearum 252 4e-67 NMB0670 [F] COG0125 Thymidylate kinase Nme Neisseria meningitidi... 189 4e-48 PA2962 [F] COG0125 Thymidylate kinase Pae Pseudomonas aeruginosa 188 7e-48 NMA0869 [F] COG0125 Thymidylate kinase NmA Neisseria meningitidi... 186 4e-47 SP0935 [F] COG0125 Thymidylate kinase Spn Streptococcus pneumoni... 139 4e-33 >RSc1784 [F] COG0125 Thymidylate kinase Rso Ralstonia solanacearum Length = 205 Score = 252 bits (644), Expect = 4e-67, Method: Compositional matrix adjust. Identities = 137/216 (63%), Positives = 158/216 (73%), Gaps = 16/216 (7%) Query: 3 SGKFITFEGIDGAGKSTHIPFVTQLLRDR----GLTVVATREPGGTELGERLRELVLHHK 58 +GKFITFEGIDGAGKSTH+ + Q L R G VV TREPGGT LGERLRE++LH + Sbjct: 2 TGKFITFEGIDGAGKSTHLAWFAQQLEARLAPQGRKVVVTREPGGTPLGERLREVLLHER 61 Query: 59 MHLETEALLMFASRREHLAQVIEPALARGDWVISDRFTDATFAYQGGGRKLALDKLDRLE 118 MHLETEALLMFASRREH+A+VI+PAL RGDWVISDRFTDATFAYQGGGR LA+++L+ LE Sbjct: 62 MHLETEALLMFASRREHIAEVIQPALERGDWVISDRFTDATFAYQGGGRGLAIERLEALE 121 Query: 119 QWVHPHLQPDLTLLFDVPLEVAXAAGPDAALRCPAGYSDAERTLDKFEQEKADFFANTRA 178 QWV LQP TLLFD+ EVA A DA RT DKFE E A FF TRA Sbjct: 122 QWVQQGLQPTRTLLFDLAPEVAAARLADA------------RTPDKFEAESAQFFVRTRA 169 Query: 179 EYLRRAAQFPQRFRLIDSTRPIAVIQEDLRAIVAAL 214 EYLRRAA P RF +ID+ R I++DL ++A+L Sbjct: 170 EYLRRAAAEPGRFVVIDAARARDDIRKDLEKLLASL 205 >NMB0670 [F] COG0125 Thymidylate kinase Nme Neisseria meningitidis MC58 Length = 206 Score = 189 bits (480), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 101/209 (48%), Positives = 135/209 (64%), Gaps = 14/209 (6%) Query: 5 KFITFEGIDGAGKSTHIPFVTQLLRDRGLTVVATREPGGTELGERLRELVLH--HKMHLE 62 +FIT +GIDGAGKST++ + RGL V+ TREPGGT +GE LRE++L+ K L Sbjct: 4 QFITLDGIDGAGKSTNLAVIKAWFERRGLPVLFTREPGGTPVGEALREILLNPETKAGLR 63 Query: 63 TEALLMFASRREHLAQVIEPALARGDWVISDRFTDATFAYQGGGRKLALDKLDRLEQWVH 122 E L+MFA+R +H+ +VI PAL+ G V+SDRFTDATFAYQGGGR + + ++ LE WV Sbjct: 64 AETLMMFAARMQHIEEVILPALSDGIHVVSDRFTDATFAYQGGGRGMPSEDIEILEHWVQ 123 Query: 123 PHLQPDLTLLFDVPLEVAXAAGPDAALRCPAGYSDAERTLDKFEQEKADFFANTRAEYLR 182 L+PDLTLL DVPLEV+ A R D+FEQE+ADFF R YL Sbjct: 124 GGLKPDLTLLLDVPLEVSMA------------RIGQTREKDRFEQEQADFFMRVRGVYLD 171 Query: 183 RAAQFPQRFRLIDSTRPIAVIQEDLRAIV 211 RAA P+R+ +IDS R + ++ + ++ Sbjct: 172 RAAACPERYAVIDSNRNLDEVRNSIEKVL 200 >PA2962 [F] COG0125 Thymidylate kinase Pae Pseudomonas aeruginosa Length = 210 Score = 188 bits (478), Expect = 7e-48, Method: Compositional matrix adjust. Identities = 103/208 (49%), Positives = 138/208 (66%), Gaps = 15/208 (7%) Query: 3 SGKFITFEGIDGAGKSTHIPFVTQLLRDRGLTVVATREPGGTELGERLRELVL---HHKM 59 +G F+T EG +GAGKST+ ++ + LR+RG+ V TREPGGT L ER+REL+L M Sbjct: 2 TGLFVTLEGPEGAGKSTNRDYLAERLRERGIEVQLTREPGGTPLAERIRELLLAPSDEPM 61 Query: 60 HLETEALLMFASRREHLAQVIEPALARGDWVISDRFTDATFAYQGGGRKLALDKLDRLEQ 119 +TE LLMFA+R +HLA VI PALARG V+ DRFTDAT+AYQGGGR L ++ LE Sbjct: 62 AADTELLLMFAARAQHLAGVIRPALARGAVVLCDRFTDATYAYQGGGRGLPEARIAALES 121 Query: 120 WVHPHLQPDLTLLFDVPLEVAXAAGPDAALRCPAGYSDAERTLDKFEQEKADFFANTRAE 179 +V L+PDLTL+FD+P+E+ A + A LD+FEQE FF R Sbjct: 122 FVQGDLRPDLTLVFDLPVEIGLA------------RAAARGRLDRFEQEDRRFFEAVRQT 169 Query: 180 YLRRAAQFPQRFRLIDSTRPIAVIQEDL 207 YL+RAAQ P+R++++D+ P+A +Q L Sbjct: 170 YLQRAAQAPERYQVLDAGLPLAEVQAGL 197 >NMA0869 [F] COG0125 Thymidylate kinase NmA Neisseria meningitidis Z2491 Length = 206 Score = 186 bits (471), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 100/209 (47%), Positives = 134/209 (64%), Gaps = 14/209 (6%) Query: 5 KFITFEGIDGAGKSTHIPFVTQLLRDRGLTVVATREPGGTELGERLRELVLH--HKMHLE 62 +FIT +GIDGAGKST++ + RGL V+ TREPGGT +GE LRE++L+ K L Sbjct: 4 QFITLDGIDGAGKSTNLAVIKAWFERRGLPVLFTREPGGTPVGEALREILLNPETKAGLR 63 Query: 63 TEALLMFASRREHLAQVIEPALARGDWVISDRFTDATFAYQGGGRKLALDKLDRLEQWVH 122 E L+MFA+R +H+ VI PAL+ G V+SDRFTDATFAYQGGGR + + ++ LE WV Sbjct: 64 AETLMMFAARMQHIEDVILPALSDGIHVVSDRFTDATFAYQGGGRGMPSEDIEILEHWVQ 123 Query: 123 PHLQPDLTLLFDVPLEVAXAAGPDAALRCPAGYSDAERTLDKFEQEKADFFANTRAEYLR 182 L+PDLTLL DVPLEV+ A R D+FEQE+ADFF R+ YL Sbjct: 124 GGLRPDLTLLLDVPLEVSMA------------RIGQTREKDRFEQEQADFFMRVRSVYLN 171 Query: 183 RAAQFPQRFRLIDSTRPIAVIQEDLRAIV 211 RAA P+R+ +IDS + ++ + ++ Sbjct: 172 RAAACPERYAVIDSNLGLDEVRNSIEKVL 200 >SP0935 [F] COG0125 Thymidylate kinase Spn Streptococcus pneumoniae TIGR4 Length = 212 Score = 139 bits (350), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 78/214 (36%), Positives = 125/214 (58%), Gaps = 13/214 (6%) Query: 1 MASGKFITFEGIDGAGKSTHIPFVTQLLRDRGLTVVATREPGGTELGERLRELVL---HH 57 M+ G ++ EG +GAGK++ + + +L ++G+ V+ TREPGG +GE++RE++L H Sbjct: 1 MSKGFLVSLEGPEGAGKTSVLEALLPILEEKGVEVLTTREPGGVLIGEKIREVILDPSHT 60 Query: 58 KMHLETEALLMFASRREHLAQVIEPALARGDWVISDRFTDATFAYQGGGRKLALDKLDRL 117 +M +TE LL ASRR+HL + + PAL G VI DRF D++ AYQG GR L ++ +D L Sbjct: 61 QMDAKTELLLYIASRRQHLVEKVLPALEAGKLVIMDRFIDSSVAYQGFGRGLDIEAIDWL 120 Query: 118 EQWVHPHLQPDLTLLFDVPLEVAXAAGPDAALRCPAGYSDAERTLDKFEQEKADFFANTR 177 Q+ L+PDLTL FD+ +E A R A +++R +++ + E D R Sbjct: 121 NQFATDGLKPDLTLYFDIEVEEGLA-------RIAA---NSDREVNRLDLEGLDLHKKVR 170 Query: 178 AEYLRRAAQFPQRFRLIDSTRPIAVIQEDLRAIV 211 YL + R ID++ P+ + E +A++ Sbjct: 171 QGYLSLLDKEGNRIVKIDASLPLEQVVETTKAVL 204