BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0018.0139.p (1050 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp1199 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1073 0.0 RSp1198 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1057 0.0 PA1436 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas ... 1040 0.0 mll5779 [V] COG0841 Cation/multidrug efflux pump Mlo Mesorhizobi... 1033 0.0 PA2527 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas ... 1020 0.0 >RSp1199 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1033 Score = 1073 bits (2776), Expect = 0.0, Method: Compositional matrix adjust. Identities = 552/1029 (53%), Positives = 738/1029 (71%), Gaps = 24/1029 (2%) Query: 1 VSVSAAFIKRPIGTTLLAIAILLVGVAVWPLLPVAPLPQVDFPTIQVTAQLPGGSPETMA 60 +++SA FI RP+ T LL I + L G+A + LLPV+PLPQVDFPTI V A LPG SPETMA Sbjct: 1 MNLSATFIARPVATALLTIGVALAGIAAFNLLPVSPLPQVDFPTISVNASLPGASPETMA 60 Query: 61 SNVAQPLERQFSLIAGLSQMTSQSTLGSTQITLQFDLNRNIDAAALDVQAAINASTGQLP 120 + VA PLER IAG+++MTSQS LGST++TLQFDL+R+ID AA DVQAAINAS LP Sbjct: 61 ATVATPLERSLGRIAGITEMTSQSALGSTRVTLQFDLSRDIDGAARDVQAAINASRSLLP 120 Query: 121 ANLPNPPTFRKINPADSPIMIMSVQSEALPLTVVNDYADNILAQQISQISGVGLVNVNGQ 180 + LP+ PT+RK+NPAD+PIMI+ + S+ + D A ILAQ++SQI+GVG VN+ G Sbjct: 121 SGLPSNPTYRKVNPADAPIMILGLTSDTKSRGELYDAASTILAQKLSQITGVGQVNIGGA 180 Query: 181 QKPAVRIQVDPAKLATLGLSLEDIRGVIATTTVNQPKGTVDGARQAFTVYTNDQLLKAEQ 240 PAVR++++P L G+S E +R VI T N+PKG ++ + +T+Y NDQ AE+ Sbjct: 181 SLPAVRVELNPTALNKYGISTETVRTVITATNANKPKGMLEAGNRVWTLYANDQARHAEE 240 Query: 241 WNDMVLAWRNGAPIRVKDIGIAVDGPENNKIAAWAFAGAANTADHSITNGR-SIVLAITK 299 + +++A+RNGAP+R+ D+ D ++ + ++ NG+ S++L I + Sbjct: 241 YKPLIIAYRNGAPVRLSDVAEVTDSVQDIR-------------NYGSANGKPSVLLIINR 287 Query: 300 QPGANVIETVGRIKAAMPRLRAAIPAAIHVNTLIDRTQTIRASVEDVEFTLVLTIALVVM 359 QPGAN+I+TV RI A +P LR IPA I+++ ++DRT TIRAS+ DVE TL+L+I LV+M Sbjct: 288 QPGANIIDTVDRINAILPYLRNTIPAQINLDVMMDRTPTIRASLRDVERTLMLSIGLVIM 347 Query: 360 VIFVFLRNVAATLIPSVTVPLAIMGTAGVMYVVGYSLDNLSLMALTIAVG-LVDDAIVML 418 V+++FLRN+ ATLIPSV VP++++GT GVMY+ GYSLDNLSLMALT+A G +VDDAIV+L Sbjct: 348 VVYLFLRNLRATLIPSVAVPVSLIGTFGVMYLCGYSLDNLSLMALTVATGFVVDDAIVVL 407 Query: 419 ENIYRYVEEGMTPLEAALKGAGEIGFTIISISVSLVAVFIPLLLMGGIVGRLFREFAVTV 478 EN+ R++E GM P++AALKGA E+GFT++S+S SL+AVFIPLL+MGGIVGRLFREFAVT+ Sbjct: 408 ENVSRHIENGMRPMQAALKGAREVGFTVVSMSFSLIAVFIPLLMMGGIVGRLFREFAVTL 467 Query: 479 TLTIAVSVIISLTLTPMLCSRFLKNEHGQRHGKLYQWFERCFDAMLAGYKRGLDVVMKHQ 538 ++ I VS+ ISLT TPM+C+R LK + G ++ E F+ +L GY+ L ++H Sbjct: 468 SVAILVSLAISLTTTPMMCARLLKPASEEEPGWFHRKTEGFFNLLLDGYRHSLAWALRHS 527 Query: 539 FITLMSFIATVALTAVLFIFIPKGFFPQQDNGVIVGFAESAQDTSSAAMHERLLKVAEVV 598 ++TL+ +ATV L L++ +PKGFFPQQD G ++GF ++ Q S AM +L+ +V Sbjct: 528 WLTLLILLATVCLNGYLYVVVPKGFFPQQDVGRLMGFIQADQAISFQAMRTKLVDFIHIV 587 Query: 599 RQDP---DVIGFAMSAGSTTFNTGQFFIALKPKDQGRTTNADEIIARLRPKVARIEGVNL 655 +QDP +V+GF G + N+GQ FI LKP + R +AD++I RLR K+AR G NL Sbjct: 588 QQDPAVENVVGFT---GGSQINSGQMFIQLKPLAE-RKLSADQVINRLRGKLAREPGANL 643 Query: 656 FMQASQDINVGGRLSRTQYQYTITDTDLDELNVWAPRMLERFRQLPQLTDVASDQQNQAA 715 F+QA QDI +GGR S QYQYT+ +L+EL W P++ + Q+ L DV +D Q++ Sbjct: 644 FLQAVQDIRIGGRPSNAQYQYTLQADNLEELRAWEPKIRQALTQIKSLVDVNTDAQDKGQ 703 Query: 716 AAVITIDRARASSFGISPSLIDATIYDAIGQRQVAQYFTQINSYRVILEVTPALQKDAAL 775 + DR +A + GI+P ID + +A GQRQV+ + +N YRV++E P ++ Sbjct: 704 QTALVFDRDKAMALGITPKDIDNALNNAFGQRQVSTIYNPLNQYRVVMEAAPQYWQNPEG 763 Query: 776 FDKLYLTSPLTGQQVPLSTFVKIDTSKTSYLSISHQSQFPAVTISFNLAKGVSLGEAVDV 835 +YL + +G QVPLSTF + T L+++HQ QF A T+SFNLA G SL A Sbjct: 764 LRDIYLITA-SGAQVPLSTFSHYGPTNTP-LAVNHQGQFAASTLSFNLAPGASLSAATQQ 821 Query: 836 IQKTKDEMGVPQTLVGNFQGTAKAFGDSLSSQPYLIAAALIAVYIVLGLLYESYIHPLTI 895 IQ + +GVP T+ G+FQGTA+AF DSLSSQP LI ALI +YIVLG+LYESY+HP+TI Sbjct: 822 IQDAMNRIGVPTTVHGSFQGTARAFQDSLSSQPVLILFALITIYIVLGVLYESYVHPITI 881 Query: 896 LSTLPSAGVGALLILMAGGYDLSVIALIGIILLIGIVKKNGIMMIDFALTAERSQGMKPE 955 LSTLPSAGVGALL L+ D SVIALIG+ILLIGIVKKN IMMIDFAL AERSQGM P Sbjct: 882 LSTLPSAGVGALLALIVTDTDFSVIALIGVILLIGIVKKNAIMMIDFALEAERSQGMSPA 941 Query: 956 QAIYQACLLRFRPIMMTTMCALLSGLPLMLGHGAGSELRRPLGYAMVGGLILSQALTLFT 1015 AI+ AC+LRFRPI+MTTM ALL LPL LGHG G+ELR+PLG ++VGGL++SQ LTL+T Sbjct: 942 DAIFHACVLRFRPILMTTMAALLGALPLALGHGDGAELRQPLGISIVGGLLVSQILTLYT 1001 Query: 1016 TPVVYLYLD 1024 TPVVYL LD Sbjct: 1002 TPVVYLALD 1010 >RSp1198 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1041 Score = 1057 bits (2734), Expect = 0.0, Method: Compositional matrix adjust. Identities = 553/1043 (53%), Positives = 740/1043 (70%), Gaps = 20/1043 (1%) Query: 4 SAAFIKRPIGTTLLAIAILLVGVAVWPLLPVAPLPQVDFPTIQVTAQLPGGSPETMASNV 63 S FI RP+ TTLL +AILL G+ + +LP++ LP+VD+PTIQVT PG SP+ M S++ Sbjct: 4 SRIFILRPVATTLLMVAILLSGLVAYRMLPLSALPEVDYPTIQVTTLYPGASPDVMTSSI 63 Query: 64 AQPLERQFSLIAGLSQMTSQSTLGSTQITLQFDLNRNIDAAALDVQAAINASTGQLPANL 123 PLERQF + GL QMTS S+ G++ ITLQFDL+ ++D A +VQAAINA+ LP +L Sbjct: 64 TAPLERQFGQMPGLKQMTSASSGGASVITLQFDLSLSLDIAEQEVQAAINAAGNLLPTDL 123 Query: 124 PNPPTFRKINPADSPIMIMSVQSEALPLTVVNDYADNILAQQISQISGVGLVNVNGQQKP 183 P PP + K+NPAD+PI+ +++ S LPL + D D +AQ++SQ+ G+GLV+++G Q+P Sbjct: 124 PMPPIYSKVNPADAPILTLAITSRTLPLPKLEDIVDTRVAQKLSQLPGIGLVSISGGQRP 183 Query: 184 AVRIQVDPAKLATLGLSLEDIRGVIATTTVNQPKGTVDGARQAFTVYTNDQLLKAEQWND 243 AVRIQ + LA LGLS++DIR I VN KG+ DG +A T+ NDQL A ++ Sbjct: 184 AVRIQANTQALAALGLSIDDIRTAIGNANVNGAKGSFDGPMRASTIDANDQLRSAAEYGT 243 Query: 244 MVLAWRNGAPIRVKDIGIAVDGPENNKIAAWAFAGAANTADHSITNGRSIVLAITKQPGA 303 M++A++NGAPIR+ D+ +DG EN+K+AAWA NT +I+L + +QPGA Sbjct: 244 MIVAYKNGAPIRLTDVAQIIDGAENSKLAAWA-----NTTP-------AIILNVQRQPGA 291 Query: 304 NVIETVGRIKAAMPRLRAAIPAAIHVNTLIDRTQTIRASVEDVEFTLVLTIALVVMVIFV 363 NVI+ V R KA +P+L+ +PA I V L DRT TIRASV DV+F L+L +ALVVMVIF+ Sbjct: 292 NVIDVVNRAKALLPQLKDTLPANIDVAVLTDRTTTIRASVADVQFELLLAVALVVMVIFL 351 Query: 364 FLRNVAATLIPSVTVPLAIMGTAGVMYVVGYSLDNLSLMALTIAVG-LVDDAIVMLENIY 422 FLRN+ AT+IP+V VPL+++GT GVMY+ G+S++NL+LMALTIA G +VDDAIVM+ENI Sbjct: 352 FLRNIPATIIPAVAVPLSLVGTFGVMYLAGFSVNNLTLMALTIATGFVVDDAIVMIENIA 411 Query: 423 RYVEEGMTPLEAALKGAGEIGFTIISISVSLVAVFIPLLLMGGIVGRLFREFAVTVTLTI 482 RY+E+G P+EAALKGA +IGFTIIS++ SL+AV IPLL M +VGRLFREFA+T+ ++I Sbjct: 412 RYIEDGDPPMEAALKGARQIGFTIISLTFSLIAVLIPLLFMSDVVGRLFREFAITLAVSI 471 Query: 483 AVSVIISLTLTPMLCSRFLKNEHGQRHGKLYQWFERCFDAMLAGYKRGLDVVMKHQFITL 542 +S ++SLTLTPM+C+R L++ + Y + FD ++A Y R L V+ Q TL Sbjct: 472 LISAVVSLTLTPMMCARLLRHIPEPEQTRFYHAAGQFFDNVIAQYGRMLQWVLDRQRTTL 531 Query: 543 MSFIATVALTAVLFIFIPKGFFPQQDNGVIVGFAESAQDTSSAAMHERLLKVAEVVRQDP 602 + I T+ALT +L++++PKGFFP QD GVI G +++ Q S AM ER K+AEV+ +DP Sbjct: 532 LVAIGTLALTGLLYVYVPKGFFPVQDTGVIQGISDATQSISFPAMAERQQKLAEVILKDP 591 Query: 603 DVIGFAMSAG----STTFNTGQFFIALKPKDQGRTTNADEIIARLRPKVARIEGVNLFMQ 658 V + G +TT N+G+ I LKPKD R +A EII RL+P++A++ G++LFMQ Sbjct: 592 AVESLSSFIGVDGTNTTLNSGRMLINLKPKD-ARDADATEIIQRLQPELAKVGGISLFMQ 650 Query: 659 ASQDINVGGRLSRTQYQYTITDTDLDELNVWAPRMLERFRQLPQLTDVASDQQNQAAAAV 718 QD+ + R+SRTQYQ+T+ D D + L+ W PR++ER +Q +L DVASD Q+ A Sbjct: 651 PVQDLTIEDRVSRTQYQFTVEDPDPNNLSKWVPRLVERLQQTGELRDVASDLQDNGLRAY 710 Query: 719 ITIDRARASSFGISPSLIDATIYDAIGQRQVAQYFTQINSYRVILEVTPALQKDAALFDK 778 + IDR +A+ +G++ + +D+ +Y A GQR ++ FTQ N YRV+LE P LQK Sbjct: 711 VQIDRDKAAVYGVTTAAVDSALYSAYGQRLISTIFTQSNQYRVVLEAAPQLQKGPQSLYD 770 Query: 779 LYLTSPLTGQQVPLSTFVKIDTSKTSYLSISHQSQFPAVTISFNLAKGVSLGEAVDVIQK 838 L + S GQQVPL F + + L ++HQ QFP+ TISFNLA+G SLG AVD I Sbjct: 771 LRVAS-TGGQQVPLGAFATV-VEQPGSLVVNHQGQFPSATISFNLARGASLGAAVDAINA 828 Query: 839 TKDEMGVPQTLVGNFQGTAKAFGDSLSSQPYLIAAALIAVYIVLGLLYESYIHPLTILST 898 + +G+P ++ +FQG A AF SLS++ +LI AA+I +YIVLG+LYES IHP+TILST Sbjct: 829 AEQAIGLPASMQTSFQGAALAFQSSLSNELWLILAAIITMYIVLGVLYESTIHPVTILST 888 Query: 899 LPSAGVGALLILMAGGYDLSVIALIGIILLIGIVKKNGIMMIDFALTAERSQGMKPEQAI 958 LPSAGVGALL L+ G D+ +IA+IGIILLIGIVKKN IMMIDFAL AER QGM P AI Sbjct: 889 LPSAGVGALLSLLVSGKDMGIIAIIGIILLIGIVKKNAIMMIDFALEAEREQGMAPRDAI 948 Query: 959 YQACLLRFRPIMMTTMCALLSGLPLMLGHGAGSELRRPLGYAMVGGLILSQALTLFTTPV 1018 YQACLLRFRPI+MTTM ALL LPLMLG G GSELR+PLG MVGGL++SQ LTLFTTPV Sbjct: 949 YQACLLRFRPILMTTMAALLGALPLMLGTGVGSELRQPLGITMVGGLLVSQVLTLFTTPV 1008 Query: 1019 VYLYLDRAHCWYMRKKEARQARK 1041 +YL D +E R AR+ Sbjct: 1009 IYLAFDSLGHRLRDWRERRAARR 1031 >PA1436 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas aeruginosa Length = 1036 Score = 1040 bits (2689), Expect = 0.0, Method: Compositional matrix adjust. Identities = 524/1001 (52%), Positives = 720/1001 (71%), Gaps = 31/1001 (3%) Query: 34 VAPLPQVDFPTIQVTAQLPGGSPETMASNVAQPLERQFSLIAGLSQMTSQSTLGSTQITL 93 VAPLP+ DFPTIQ+ A LPGGSPETMAS+VA PLE QFS I G+++MTS S LG+T +TL Sbjct: 38 VAPLPEADFPTIQINALLPGGSPETMASSVATPLEVQFSAIPGITEMTSSSALGTTTLTL 97 Query: 94 QFDLNRNIDAAALDVQAAINASTGQLPANLPNPPTFRKINPADSPIMIMSVQSEALPLTV 153 QF L+++ID AA +VQAAINA+ G+LP ++PN PT+RK+NPADSPIMI+ V SE +PL Sbjct: 98 QFSLDKSIDVAAQEVQAAINAAAGRLPVDMPNLPTWRKVNPADSPIMILRVNSEMMPLIE 157 Query: 154 VNDYADNILAQQISQISGVGLVNVNGQQKPAVRIQVDPAKLATLGLSLEDIRGVIATTTV 213 ++DYA+ ILA+Q+SQ++GVG + V GQQ+PA+RIQ P KLA L+L D+R + + +V Sbjct: 158 LSDYAETILARQLSQVNGVGQIFVVGQQRPAIRIQAQPEKLAAYQLTLADLRQSLQSASV 217 Query: 214 NQPKGTVDGARQAFTVYTNDQLLKAEQWNDMVLAWRNGAPIRVKDIGIAVDGPENNKIAA 273 N KG + G + T+ NDQL A ++D+V+A+R GAP+ +KD+ V PE++ + A Sbjct: 218 NLAKGALYGEGRVSTLAANDQLFNASDYDDLVVAYRQGAPVFLKDVARIVSAPEDDYVQA 277 Query: 274 WAFAGAANTADHSITNG-RSIVLAITKQPGANVIETVGRIKAAMPRLRAAIPAAIHVNTL 332 W NG + L I +QPGAN+++T I+AA+PRLR +PA I V+ L Sbjct: 278 W-------------PNGVPGVALVILRQPGANIVDTADAIQAALPRLREMLPATIEVDVL 324 Query: 333 IDRTQTIRASVEDVEFTLVLTIALVVMVIFVFLRNVAATLIPSVTVPLAIMGTAGVMYVV 392 DRT+TIR+S+ +VE TL+LTI LVV+V+ +FLR ++ATLI + + +++ + MYV+ Sbjct: 325 NDRTRTIRSSLHEVELTLLLTIGLVVLVMGLFLRQLSATLIVATVLAVSLSASFAAMYVL 384 Query: 393 GYSLDNLSLMALTIAVG-LVDDAIVMLENIYRYVEEGMTPLEAALKGAGEIGFTIISISV 451 G++L+NL+L+AL IAVG +VDDAIV++ENI+R++E G + +EAALKGA EIGFT+ISIS Sbjct: 385 GFTLNNLTLVALIIAVGFIVDDAIVVVENIHRHLEAGASKVEAALKGAAEIGFTVISISF 444 Query: 452 SLVAVFIPLLLMGGIVGRLFREFAVTVTLTIAVSVIISLTLTPMLCSRF---LKNEHGQR 508 SL+A FIPLL MGGIVGRLFREFAV+VT+ I +SV+ SLTL PML SRF L++ R Sbjct: 445 SLIAAFIPLLFMGGIVGRLFREFAVSVTVAILISVVASLTLAPMLASRFMPALRHAEAPR 504 Query: 509 HGKLYQWFERCFDAMLAGYKRGLDVVMKHQFITLMSFIATVALTAVLFIFIPKGFFPQQD 568 G +W + GY+RGL + HQ + L+ F TV + ++ IPKGFFP QD Sbjct: 505 KG-FAEW-------LTGGYERGLRWALGHQRLMLVGFAFTVLVAVAGYVGIPKGFFPLQD 556 Query: 569 NGVIVGFAESAQDTSSAAMHERLLKVAEVVRQDPDVIGF----AMSAGSTTFNTGQFFIA 624 + G +++A+D S M + ++AE++ DP V + ++ GS + G+F+I Sbjct: 557 TAFVFGTSQAAEDISYDDMVAKHRQLAEIIASDPAVQSYNHAVGVTGGSQSLANGRFWIV 616 Query: 625 LKPKDQGRTTNADEIIARLRPKVARIEGVNLFMQASQDINVGGRLSRTQYQYTITDTDLD 684 LK + + R + E I RLRP++A++ G+ L+++A+QDIN+ SRTQYQY + +D Sbjct: 617 LKDRGE-RDVSVGEFIDRLRPQLAKVPGIMLYLRAAQDINLSSGPSRTQYQYALRSSDST 675 Query: 685 ELNVWAPRMLERFRQLPQLTDVASDQQNQAAAAVITIDRARASSFGISPSLIDATIYDAI 744 +L +WA R+ ER +Q+P L DV++D Q A+ + IDR A+ FG+S + T+YDA Sbjct: 676 QLALWAQRLTERLKQVPGLMDVSNDLQVGASVTALDIDRVAAARFGLSAEDVSQTLYDAF 735 Query: 745 GQRQVAQYFTQINSYRVILEVTPALQKDAALFDKLYLTSPLTGQQVPLSTFVKIDTSKTS 804 GQRQV +Y T++N Y+V+LE+ + A D YL SPL+G+ VPLS K+ ++ Sbjct: 736 GQRQVGEYQTEVNQYKVVLELDARQRGRAESLDWFYLRSPLSGEMVPLSAIAKVAAPRSG 795 Query: 805 YLSISHQSQFPAVTISFNLAKGVSLGEAVDVIQKTKDEMGVPQTLVGNFQGTAKAFGDSL 864 L I+H FPAV +SFNLA GVSLGEAV +Q+ ++E+G+P T++G FQG A+AF SL Sbjct: 796 PLQINHNGMFPAVNLSFNLAAGVSLGEAVQAVQRAQEEIGMPSTIIGVFQGAAQAFQSSL 855 Query: 865 SSQPYLIAAALIAVYIVLGLLYESYIHPLTILSTLPSAGVGALLILMAGGYDLSVIALIG 924 +SQP LI AALIAVYI+LG+LYES++HPLTILSTLPSAG+GA+ +L A G D S++ALIG Sbjct: 856 ASQPLLILAALIAVYIILGVLYESFVHPLTILSTLPSAGIGAVFLLWAWGQDFSIMALIG 915 Query: 925 IILLIGIVKKNGIMMIDFALTAERSQGMKPEQAIYQACLLRFRPIMMTTMCALLSGLPLM 984 I+LLIGIVKKNGI+M+DFA+ A+R QGM EQAIYQACL RFRPIMMTT+ ALL +PLM Sbjct: 916 IVLLIGIVKKNGILMVDFAIVAQREQGMSAEQAIYQACLTRFRPIMMTTLAALLGAIPLM 975 Query: 985 LGHGAGSELRRPLGYAMVGGLILSQALTLFTTPVVYLYLDR 1025 +G G GSELR+PLG A+VGGL++SQ LTLF+TPVVYL L+R Sbjct: 976 IGFGTGSELRQPLGIAVVGGLLVSQVLTLFSTPVVYLALER 1016 >mll5779 [V] COG0841 Cation/multidrug efflux pump Mlo Mesorhizobium loti Length = 1038 Score = 1033 bits (2672), Expect = 0.0, Method: Compositional matrix adjust. Identities = 553/1051 (52%), Positives = 750/1051 (71%), Gaps = 18/1051 (1%) Query: 1 VSVSAAFIKRPIGTTLLAIAILLVGVAVWPLLPVAPLPQVDFPTIQVTAQLPGGSPETMA 60 +SVS F++RPI T LL + I+LVG+ + LLP++ LPQVDFPTI V + LPG ETMA Sbjct: 1 MSVSNIFVQRPIATGLLTLGIVLVGMVAYMLLPISSLPQVDFPTIAVESTLPGAKAETMA 60 Query: 61 SNVAQPLERQFSLIAGLSQMTSQSTLGSTQITLQFDLNRNIDAAALDVQAAINASTGQLP 120 S VA PLE+QFS I GL+QMTS STLG T +TLQFDL+RNID+AA DVQAAINA++G LP Sbjct: 61 STVASPLEQQFSTIPGLAQMTSTSTLGKTDMTLQFDLSRNIDSAAQDVQAAINAASGSLP 120 Query: 121 ANLPNPPTFRKINPADSPIMIMSVQSEALPLTVVNDYADNILAQQISQISGVGLVNVNGQ 180 + +PPT+ K+NPA ++ + +QS+ +PL +V D A N++AQ +SQI G G V++ G Sbjct: 121 KAMQSPPTYHKVNPALFTVISIVLQSDTIPLPLVMDAASNMVAQTLSQIPGAGFVDMPGS 180 Query: 181 QKPAVRIQVDPAKLATLGLSLEDIRGVIATTTVNQPKGTVDGARQAFTVYTNDQLLKAEQ 240 K A+RIQ+DP KLA+LG+SLED+R + T N PKGT++GA+++ T+ N+QLL + Sbjct: 181 SKSAIRIQLDPMKLASLGMSLEDVRSALVVGTTNGPKGTLEGAQRSVTLDANNQLLTSAD 240 Query: 241 WNDMVLAWRNGAPIRVKDIGIAVDGPENNKIAAWAFAGAANTADHSITNGRSIVLAITKQ 300 + ++A+RNG+PIR+ DIG A+D EN + AW N +++++ + Q Sbjct: 241 ASAAIIAYRNGSPIRISDIGRAIDSVENTTLGAW------------YNNRKAVLIDVHLQ 288 Query: 301 PGANVIETVGRIKAAMPRLRAAIPAAIHVNTLIDRTQTIRASVEDVEFTLVLTIALVVMV 360 GAN ++ V +KAA+P LR +P ++ + T D T +RA+V DV+FTL++TI LVV+ Sbjct: 289 SGANAVDVVNGVKAALPGLRLRLPPSVQIMTAGDSTVAVRAAVADVQFTLMITIGLVVLT 348 Query: 361 IFVFLRNVAATLIPSVTVPLAIMGTAGVMYVVGYSLDNLSLMALTIAVG-LVDDAIVMLE 419 IF+FL++++AT+IP+VT+P++++GT GVMY++GYSLDN+SLM LTIAVG +VDDAIV++E Sbjct: 349 IFLFLKSMSATIIPAVTIPVSLIGTFGVMYLLGYSLDNISLMGLTIAVGFVVDDAIVVIE 408 Query: 420 NIYRYVEEGMTPLEAALKGAGEIGFTIISISVSLVAVFIPLLLMGGIVGRLFREFAVTVT 479 NI R++E G +PLEA LKGA EIGFT++S++ SL+AVFIPLLLM +VGRLFREF+VT+ Sbjct: 409 NIVRHIEGGESPLEATLKGASEIGFTVVSMTASLIAVFIPLLLMSSMVGRLFREFSVTIA 468 Query: 480 LTIAVSVIISLTLTPMLCSRFLKNE-HGQRHGKLYQWFERCFDAMLAGYKRGLDVVMKHQ 538 + + +S ++SLTLTPM+C+ +K H + +L ER FD + GY R L VV+ H Sbjct: 469 VALIISALVSLTLTPMMCALMIKGHGHEAKPNRLSSLLERGFDFIQRGYSRSLRVVVGHP 528 Query: 539 FITLMSFIATVALTAVLFIFIPKGFFPQQDNGVIVGFAESAQDTSSAAMHERLLKVAEVV 598 + L+ F AT+A+TA LF+ IPKGFFPQQD G+I G ++AQD S AM + V +++ Sbjct: 529 RLVLLCFFATLAVTAELFLAIPKGFFPQQDLGLISGSTQAAQDISFQAMAAKQQAVVDLI 588 Query: 599 RQDPDVIGFAMS-AGSTTFNTGQFFIALKPKDQGRTTNADEIIARLRPKVARIEGVNLFM 657 +DP V + GS N+G I LKP + R+ +AD++IARLR + A + GV++ M Sbjct: 589 LKDPAVDTVRSTLGGSGRMNSGNLQIVLKPLSE-RSVSADQVIARLRKETAGVSGVSVGM 647 Query: 658 QASQDINVGGRLSRTQYQYTITDTDLDELNVWAPRMLERFRQLPQLTDVASDQQNQAAAA 717 QA Q INVG R S+TQ+QYT+ D +L EL WA M R+LPQ+ DVA+D Q A A Sbjct: 648 QAVQGINVGARGSQTQFQYTLQDPNLPELYRWADTMTAELRKLPQVRDVANDLQAVAPHA 707 Query: 718 VITIDRARASSFGISPSLIDATIYDAIGQRQVAQYFTQINSYRVILEVTPALQKDAALFD 777 I +DR AS GI+P ID T+YDA GQRQV FTQ + +++++E+ P + DA D Sbjct: 708 SIAVDRDTASRLGITPQAIDDTLYDAFGQRQVTTIFTQADQHKIVMEIDPKYRVDAGALD 767 Query: 778 KLYLTSPLTGQQVPLSTFVKIDTSKTSYLSISHQSQFPAVTISFNLAKGVSLGEAVDVIQ 837 +Y+ S +G+QVPLS F K+ +S + L+I+HQ FP+VT+SFNLA V+LG+AV ++ Sbjct: 768 AIYVGSN-SGKQVPLSAFAKV-SSSVAPLTINHQGLFPSVTLSFNLAPNVALGDAVTAVE 825 Query: 838 KTKDEMGVPQTLVGNFQGTAKAFGDSLSSQPYLIAAALIAVYIVLGLLYESYIHPLTILS 897 + + + T+ FQGTA+AF SLS+QP LI AALIAVYIVLG+LYES IHP+TILS Sbjct: 826 AMQARIRMSATVQTGFQGTAQAFQASLSTQPMLIVAALIAVYIVLGMLYESVIHPITILS 885 Query: 898 TLPSAGVGALLILMAGGYDLSVIALIGIILLIGIVKKNGIMMIDFALTAERSQGMKPEQA 957 TLPSAGVGAL LM G L V+ L+GIILLIGIVKKN IMMIDFAL+AER +G+ P++A Sbjct: 886 TLPSAGVGALATLMLVGGQLDVMGLVGIILLIGIVKKNAIMMIDFALSAERDRGLPPKEA 945 Query: 958 IYQACLLRFRPIMMTTMCALLSGLPLMLGHGAGSELRRPLGYAMVGGLILSQALTLFTTP 1017 I QAC+LRFRPI MTT+CALL LPL LG G GSELRRPLG A+VGGL +SQ LTL+TTP Sbjct: 946 IIQACILRFRPITMTTLCALLGALPLALGTGVGSELRRPLGIAIVGGLCVSQLLTLYTTP 1005 Query: 1018 VVYLYLDRAHCWYMRKKEARQARKAARLANP 1048 V+YLY+ + M K R+ A A P Sbjct: 1006 VIYLYMQQFAGLMMGVKYRIIGRRPALPAVP 1036 >PA2527 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas aeruginosa Length = 1043 Score = 1020 bits (2638), Expect = 0.0, Method: Compositional matrix adjust. Identities = 547/1038 (52%), Positives = 738/1038 (71%), Gaps = 21/1038 (2%) Query: 4 SAAFIKRPIGTTLLAIAILLVGVAVWPLLPVAPLPQVDFPTIQVTAQLPGGSPETMASNV 63 S FI RP+ TTLL +AILL G+ + LP++ LP+VD+PTIQV PG SPE M S++ Sbjct: 4 SRPFILRPVATTLLMVAILLSGLIAYRFLPISALPEVDYPTIQVVTLYPGASPEIMTSSI 63 Query: 64 AQPLERQFSLIAGLSQMTSQSTLGSTQITLQFDLNRNIDAAALDVQAAINASTGQLPANL 123 PLE Q I GL++M+S S+ G++ ITLQF L N+D A +VQAAINA+ LP +L Sbjct: 64 TAPLENQLGQIPGLNEMSSSSSGGASVITLQFSLQSNLDVAEQEVQAAINAAQSLLPNDL 123 Query: 124 PNPPTFRKINPADSPIMIMSVQSEALPLTVVNDYADNILAQQISQISGVGLVNVNGQQKP 183 PN P F K+NPAD+PI+ ++V S+ +PL + D D LAQ+ISQISGVGLV+++G Q+P Sbjct: 124 PNQPVFSKVNPADAPILTLAVMSDGMPLPQIQDLVDTRLAQKISQISGVGLVSISGGQRP 183 Query: 184 AVRIQVDPAKLATLGLSLEDIRGVIATTTVNQPKGTVDGARQAFTVYTNDQLLKAEQWND 243 AVR++ +P LA GLSLED+R + + +N PKG+ DG +A T+ NDQL A+ + D Sbjct: 184 AVRVRANPTALAAAGLSLEDLRSTVTSNNLNGPKGSFDGPTRASTLDANDQLRSADAYRD 243 Query: 244 MVLAWRNGAPIRVKDIGIAVDGPENNKIAAWAFAGAANTADHSITNGRSIVLAITKQPGA 303 +++A++NG+P+R++D+ D EN ++AAWA N ++VL I +QPGA Sbjct: 244 LIIAYKNGSPLRIRDVASVEDDAENVRLAAWA------------NNLPAVVLNIQRQPGA 291 Query: 304 NVIETVGRIKAAMPRLRAAIPAAIHVNTLIDRTQTIRASVEDVEFTLVLTIALVVMVIFV 363 NVIE V RIKA +P+L++ +P + V L DRT TIRASV+DV+F L L +ALVVMV F+ Sbjct: 292 NVIEVVDRIKALLPQLQSTLPGNLDVQVLTDRTTTIRASVKDVQFELALAVALVVMVTFL 351 Query: 364 FLRNVAATLIPSVTVPLAIMGTAGVMYVVGYSLDNLSLMALTIAVG-LVDDAIVMLENIY 422 FLRNV ATLIPS VPL+++GT GVMY+ G+S++NL+LMALTIA G +VDDAIVM+ENI Sbjct: 352 FLRNVYATLIPSFAVPLSLIGTFGVMYLSGFSINNLTLMALTIATGFVVDDAIVMVENIA 411 Query: 423 RYVEEGMTPLEAALKGAGEIGFTIISISVSLVAVFIPLLLMGGIVGRLFREFAVTVTLTI 482 RY+E+G +PLEAALKG+ +IGFTIIS++ SL+AV IPLL MG + GRLFREFA+T+ + I Sbjct: 412 RYLEQGDSPLEAALKGSKQIGFTIISLTFSLIAVLIPLLFMGDVAGRLFREFAITLAVAI 471 Query: 483 AVSVIISLTLTPMLCSRFLKNEHGQRHGKLYQWFERCFDAMLAGYKRGLDVVMKHQFITL 542 +S +SLTLTPML ++ L++ + G+ + R D ++A Y + L VV++HQ +TL Sbjct: 472 LISGFVSLTLTPMLSAKLLRHIDEDQQGRFARAAGRVIDGLIAQYAKALRVVLRHQPLTL 531 Query: 543 MSFIATVALTAVLFIFIPKGFFPQQDNGVIVGFAESAQDTSSAAMHERLLKVAEVVRQDP 602 + IAT+ALTA+L++ +PKGFFP QD GVI G AE+ Q S AM ER +AEVV +DP Sbjct: 532 LVAIATLALTALLYLAMPKGFFPVQDTGVIQGVAEAPQSISFQAMSERQRALAEVVLKDP 591 Query: 603 DVIGFAMSAG----STTFNTGQFFIALKPKDQGRTTNADEIIARLRPKVARIEGVNLFMQ 658 V + G + T NTG+ I LKP + R A E+I RL+P++ + G+ L+MQ Sbjct: 592 AVASLSSYIGVDGSNPTLNTGRLLINLKPHSE-RDVTASEVIQRLQPELDHLPGIKLYMQ 650 Query: 659 ASQDINVGGRLSRTQYQYTITDTDLDELNVWAPRMLERFRQLPQLTDVASDQQNQAAAAV 718 QD+ + R++RTQYQ+T+ D D D L W P+++ R ++LPQL DVASD Q++ A Sbjct: 651 PVQDLTIEDRVARTQYQFTLQDADPDVLAEWVPKLVARLQELPQLADVASDWQDKGLQAY 710 Query: 719 ITIDRARASSFGISPSLIDATIYDAIGQRQVAQYFTQINSYRVILEVTPALQKDAALFDK 778 + IDR AS G+ S ID+ +Y+A GQR ++ FTQ YRV+LEV P Q ++ Sbjct: 711 LNIDRDTASRLGVKLSDIDSVLYNAFGQRLISTIFTQATQYRVVLEVAPQFQLGPQALEQ 770 Query: 779 LYLTSPLTGQQVPLSTFVKIDTSKTSYLSISHQSQFPAVTISFNLAKGVSLGEAVDVIQK 838 LY+ S G QV LS+ K++ T L+I+H +QFP+ T+SFNLAKG SLGEAV+ I+ Sbjct: 771 LYVPSS-DGTQVRLSSLAKVEERHT-LLAINHIAQFPSATLSFNLAKGYSLGEAVEAIRG 828 Query: 839 TKDEMGVPQTLVGNFQGTAKAFGDSLSSQPYLIAAALIAVYIVLGLLYESYIHPLTILST 898 + + +P ++ G+F+G A AF SLS+ LI A+++ +YIVLG+LYES+IHP+TILST Sbjct: 829 VEASLELPLSMQGSFRGAALAFEASLSNTLLLILASVVTMYIVLGILYESFIHPVTILST 888 Query: 899 LPSAGVGALLILMAGGYDLSVIALIGIILLIGIVKKNGIMMIDFALTAERSQGMKPEQAI 958 LPSAGVGALL LM G ++ ++A+IGIILLIGIVKKN IMMIDFAL AER++G P +AI Sbjct: 889 LPSAGVGALLALMLAGQEIGIVAIIGIILLIGIVKKNAIMMIDFALDAERNEGKPPHEAI 948 Query: 959 YQACLLRFRPIMMTTMCALLSGLPLMLGHGAGSELRRPLGYAMVGGLILSQALTLFTTPV 1018 YQACLLRFRPI+MTTM ALL LPLML GAG+ELR+PLG MVGGL+LSQ LTLFTTPV Sbjct: 949 YQACLLRFRPILMTTMAALLGALPLMLAGGAGAELRQPLGITMVGGLLLSQVLTLFTTPV 1008 Query: 1019 VYLYLDR-AHCWYMRKKE 1035 +YLY DR A W +K+ Sbjct: 1009 IYLYFDRLARRWAAWRKQ 1026