BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0018.0095.p (233 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0266 [H] COG0502 Biotin synthase and related enzymes Rso Rals... 290 2e-78 CC3521 [H] COG0502 Biotin synthase and related enzymes Ccr Caulo... 281 9e-76 VC1112 [H] COG0502 Biotin synthase and related enzymes Vch Vibri... 276 2e-74 STM0794 [H] COG0502 Biotin synthase and related enzymes Sty Salm... 275 6e-74 bioB [H] COG0502 Biotin synthase and related enzymes Eco Escheri... 271 7e-73 >RSc0266 [H] COG0502 Biotin synthase and related enzymes Rso Ralstonia solanacearum Length = 360 Score = 290 bits (742), Expect = 2e-78, Method: Compositional matrix adjust. Identities = 141/227 (62%), Positives = 177/227 (77%), Gaps = 8/227 (3%) Query: 14 APLHF-----HRPANAARADDTR--RDAVAALFELPFLDLLYQAQTVHRQHHPANQVQLS 66 APL+F P ++ + R R+A+ ALF LPF DLL+QAQ VHR H AN VQLS Sbjct: 4 APLNFVPDAAKVPPTPGQSPNARWSREAIEALFALPFNDLLFQAQQVHRAHFDANAVQLS 63 Query: 67 SLLSIKTGGCAEDCGYCAQSAHHKDAGVPAGKLMAVDEVVQAARAARDQGATRFCMGAAW 126 +LLSIKTGGC EDC YC QSA + D GV A KLM +D V++AA A+ GA+RFCMGAAW Sbjct: 64 TLLSIKTGGCPEDCSYCPQSARY-DTGVEAEKLMPIDTVLEAAARAKQNGASRFCMGAAW 122 Query: 127 RNPKERDMPALTEMVSQVRALGLETCMTLGMLEQAQAEALKEAGLDYYNHNLDTAPDFYG 186 RNPK + A+ +MV V+A+GLETC+TLGML+Q QA+ LK+AGLDYYNHNLDTAP+FYG Sbjct: 123 RNPKPHQLDAVADMVRGVKAMGLETCVTLGMLKQEQAQQLKDAGLDYYNHNLDTAPEFYG 182 Query: 187 QVISTRSYQDRLDTLERVHLAGLSVCCGGIIGMGETRAQRAGLIAQL 233 ++I+TR+YQDRLDTLE V AG++VCCGGI+G+GE+R +RAGL+A+L Sbjct: 183 EIITTRTYQDRLDTLEHVRDAGINVCCGGIVGLGESRHERAGLVAEL 229 >CC3521 [H] COG0502 Biotin synthase and related enzymes Ccr Caulobacter vibrioides Length = 341 Score = 281 bits (719), Expect = 9e-76, Method: Compositional matrix adjust. Identities = 133/199 (66%), Positives = 159/199 (79%), Gaps = 1/199 (0%) Query: 35 VAALFELPFLDLLYQAQTVHRQHHPANQVQLSSLLSIKTGGCAEDCGYCAQSAHHKDAGV 94 V ALF LPF++L++QA VHR H +++QLS LLS+KTGGCAE+CGYC+QSAH K G+ Sbjct: 17 VEALFALPFMELVFQAANVHRAHFDPSEIQLSQLLSVKTGGCAENCGYCSQSAHFK-TGL 75 Query: 95 PAGKLMAVDEVVQAARAARDQGATRFCMGAAWRNPKERDMPALTEMVSQVRALGLETCMT 154 A KLMA D+VV ARAARD GA RFCMGAAWR K+RD+P LTEM+ +V+ALGLETC T Sbjct: 76 KADKLMAADDVVAKARAARDGGAQRFCMGAAWRELKDRDLPKLTEMIGEVKALGLETCAT 135 Query: 155 LGMLEQAQAEALKEAGLDYYNHNLDTAPDFYGQVISTRSYQDRLDTLERVHLAGLSVCCG 214 LGML QA+ALK AGLDYYNHNLDT PD+Y V++TR+YQ+RLDTL V AG+S CCG Sbjct: 136 LGMLTADQAKALKAAGLDYYNHNLDTGPDYYKDVVTTRTYQERLDTLAHVRDAGMSTCCG 195 Query: 215 GIIGMGETRAQRAGLIAQL 233 GI+GMGE R RAGL+ QL Sbjct: 196 GIVGMGEQRRDRAGLLHQL 214 >VC1112 [H] COG0502 Biotin synthase and related enzymes Vch Vibrio cholerae Length = 350 Score = 276 bits (707), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 125/199 (62%), Positives = 156/199 (78%), Gaps = 1/199 (0%) Query: 35 VAALFELPFLDLLYQAQTVHRQHHPANQVQLSSLLSIKTGGCAEDCGYCAQSAHHKDAGV 94 V AL + PF+DLL++AQ VHR HHP N VQ+S+LLSIKTG C EDC YC QSAH++ V Sbjct: 12 VKALLDKPFMDLLFEAQQVHRLHHPHNHVQVSTLLSIKTGACPEDCKYCPQSAHYR-TDV 70 Query: 95 PAGKLMAVDEVVQAARAARDQGATRFCMGAAWRNPKERDMPALTEMVSQVRALGLETCMT 154 +LM V+ V+ AA+ A++ G+TRFCMGAAW+NPKERDMP L EM+ V+ +GLETCMT Sbjct: 71 DKERLMEVERVLDAAQKAKNSGSTRFCMGAAWKNPKERDMPLLKEMIRGVKDMGLETCMT 130 Query: 155 LGMLEQAQAEALKEAGLDYYNHNLDTAPDFYGQVISTRSYQDRLDTLERVHLAGLSVCCG 214 LGML QA+ L +AGLDYYNHNLDT+P+FYG +I+TR+YQDRLDTL V AG+ +C G Sbjct: 131 LGMLTPDQAQQLAQAGLDYYNHNLDTSPEFYGNIITTRTYQDRLDTLSHVRDAGMKICSG 190 Query: 215 GIIGMGETRAQRAGLIAQL 233 GIIGMGE+ RAGL+ +L Sbjct: 191 GIIGMGESTNDRAGLLVEL 209 >STM0794 [H] COG0502 Biotin synthase and related enzymes Sty Salmonella typhimurium LT2 Length = 346 Score = 275 bits (703), Expect = 6e-74, Method: Compositional matrix adjust. Identities = 124/199 (62%), Positives = 159/199 (79%), Gaps = 1/199 (0%) Query: 35 VAALFELPFLDLLYQAQTVHRQHHPANQVQLSSLLSIKTGGCAEDCGYCAQSAHHKDAGV 94 V LFE P L+LL++AQ +HRQH QVQ+S+LLSIKTG C EDC YC QS+ +K G+ Sbjct: 12 VTELFEKPLLELLFEAQQIHRQHFDPQQVQVSTLLSIKTGACPEDCKYCPQSSRYK-TGL 70 Query: 95 PAGKLMAVDEVVQAARAARDQGATRFCMGAAWRNPKERDMPALTEMVSQVRALGLETCMT 154 A +LM V++V+ +AR A++ G+TRFCMGAAWRNP ERDMP L ++V V+A+GLETCMT Sbjct: 71 EAERLMEVEQVLDSARKAKNAGSTRFCMGAAWRNPHERDMPYLEKIVQGVKAMGLETCMT 130 Query: 155 LGMLEQAQAEALKEAGLDYYNHNLDTAPDFYGQVISTRSYQDRLDTLERVHLAGLSVCCG 214 LGML ++QA+ L AGLDYYNHNLDT+P+FYG +I+TR+YQ+RLDTLE+V AG+ VC G Sbjct: 131 LGMLNESQAQRLANAGLDYYNHNLDTSPEFYGNIITTRTYQERLDTLEKVREAGIKVCSG 190 Query: 215 GIIGMGETRAQRAGLIAQL 233 GI+G+GET RAGL+ QL Sbjct: 191 GIVGLGETVTDRAGLLLQL 209 >bioB [H] COG0502 Biotin synthase and related enzymes Eco Escherichia coli K12 Length = 346 Score = 271 bits (694), Expect = 7e-73, Method: Compositional matrix adjust. Identities = 124/199 (62%), Positives = 157/199 (78%), Gaps = 1/199 (0%) Query: 35 VAALFELPFLDLLYQAQTVHRQHHPANQVQLSSLLSIKTGGCAEDCGYCAQSAHHKDAGV 94 V LFE P LDLL++AQ VHRQH QVQ+S+LLSIKTG C EDC YC QS+ +K G+ Sbjct: 12 VTELFEKPLLDLLFEAQQVHRQHFDPRQVQVSTLLSIKTGACPEDCKYCPQSSRYK-TGL 70 Query: 95 PAGKLMAVDEVVQAARAARDQGATRFCMGAAWRNPKERDMPALTEMVSQVRALGLETCMT 154 A +LM V++V+++AR A+ G+TRFCMGAAW+NP ERDMP L +MV V+A+GLE CMT Sbjct: 71 EAERLMEVEQVLESARKAKAAGSTRFCMGAAWKNPHERDMPYLEQMVQGVKAMGLEACMT 130 Query: 155 LGMLEQAQAEALKEAGLDYYNHNLDTAPDFYGQVISTRSYQDRLDTLERVHLAGLSVCCG 214 LG L ++QA+ L AGLDYYNHNLDT+P+FYG +I+TR+YQ+RLDTLE+V AG+ VC G Sbjct: 131 LGTLSESQAQRLANAGLDYYNHNLDTSPEFYGNIITTRTYQERLDTLEKVRDAGIKVCSG 190 Query: 215 GIIGMGETRAQRAGLIAQL 233 GI+G+GET RAGL+ QL Sbjct: 191 GIVGLGETVKDRAGLLLQL 209