BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0017.0023.p (328 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0016 [HE] COG0111 Phosphoglycerate dehydrogenase and related ... 430 e-120 VCA0630 [HE] COG0111 Phosphoglycerate dehydrogenase and related ... 371 e-102 APE1831 [CHR] COG1052 Lactate dehydrogenase and related dehydrog... 160 4e-39 MTH970 [HE] COG0111 Phosphoglycerate dehydrogenase and related d... 150 3e-36 BH1602 [HE] COG0111 Phosphoglycerate dehydrogenase and related d... 150 4e-36 >RSc0016 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases Rso Ralstonia solanacearum Length = 353 Score = 430 bits (1105), Expect = e-120, Method: Compositional matrix adjust. Identities = 206/335 (61%), Positives = 259/335 (77%), Gaps = 8/335 (2%) Query: 1 MKIAILDDYQDAVRHLDCFRLLDGHDVKVFNNTIRGVGQLAARLSPFDAVVLIRERTALT 60 MKIA+LDDYQDAVR LDCF LL H+VKVFNNT++GVGQLAAR++ +A+VLIRERT +T Sbjct: 12 MKIAVLDDYQDAVRKLDCFSLLQDHEVKVFNNTVKGVGQLAARVADVEAIVLIRERTRVT 71 Query: 61 RPLLEKLPLLKLVSQTGKVS----GHVDVAACTERGIAIVEGVGDPTAPAELTWALIMAA 116 R LL++LP LK++SQTG+VS GH+D+ ACT++G+ ++EG G P APAELTWAL+MAA Sbjct: 72 RQLLDRLPKLKIISQTGRVSRDAGGHIDLEACTDKGVVVLEGKGSPVAPAELTWALVMAA 131 Query: 117 MRRVPQYCSALRAGAWQQV----SPTPHHNLIGTALKGRTLGIWGYGKIGRLVAGYGRAF 172 RR+PQY ++L+ GAWQQ + P + IG LKG+TLGI+GYGKIG+LVAGYGRAF Sbjct: 132 QRRIPQYVASLKHGAWQQSGLKSTTMPPNFGIGRVLKGQTLGIFGYGKIGQLVAGYGRAF 191 Query: 173 GMQVLVWGRDASREQAIKDGYQAAASKEDFFAQADVLSLHLRLNDATRGIVTASDLARMK 232 GM VLVWGR+ S+E+A DG+ A SK+ F Q+DVLS+HLRLND TRGIVT +DL RMK Sbjct: 192 GMNVLVWGRENSKERARADGFAVAESKDALFEQSDVLSVHLRLNDETRGIVTVADLTRMK 251 Query: 233 ATACFVNTSRAELVEPDALEAALTAGRPGLAALDVYEREPLPVESALLKMDNVVAAPHLG 292 TA FVNTSRAELVE + + AL GRPG+AA+DV+E EP+ LL+M+N + PH+G Sbjct: 252 PTALFVNTSRAELVEENGMVTALNRGRPGMAAIDVFETEPILQGHTLLRMENCICTPHIG 311 Query: 293 YVEKDGYELYFRAAFQNIVAYAAGAPTHVLNPEAL 327 YVE++ YE+YF AFQNI+ G V NP AL Sbjct: 312 YVERESYEMYFGIAFQNILDILQGNVDSVANPTAL 346 >VCA0630 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases Vch Vibrio cholerae Length = 323 Score = 371 bits (953), Expect = e-102, Method: Compositional matrix adjust. Identities = 187/327 (57%), Positives = 230/327 (70%), Gaps = 5/327 (1%) Query: 1 MKIAILDDYQDAVRHLDCFRLLDGHDVKVFNNTIRGVGQLAARLSPFDAVVLIRERTALT 60 MKIAILDDYQ+ VR L+ F+ L GHDV VFN+++ L RL PF+A+VLIRERT +T Sbjct: 1 MKIAILDDYQNVVRGLNAFQCLQGHDVTVFNDSLSDETVLIERLKPFEALVLIRERTPIT 60 Query: 61 RPLLEKLPLLKLVSQTGKVSGHVDVAACTERGIAIVEGVGDPTAPAELTWALIMAAMRRV 120 LL LP LKL+SQTGKVS H+DVA C G+ ++EG+G P APAEL W LI+AA R + Sbjct: 61 ENLLAHLPNLKLISQTGKVSNHIDVALCERYGVTVLEGIGSPVAPAELCWGLILAASRHL 120 Query: 121 PQYCSALRAGAWQQVSPTPHHNLIGTALKGRTLGIWGYGKIGRLVAGYGRAFGMQVLVWG 180 P Y L AG WQQ +G L G TLGIWG GKIG+ +A +G FGM +LVWG Sbjct: 121 PSYIEQLHAGHWQQNGGLG----LGRTLSGHTLGIWGLGKIGQRIAQFGHVFGMPILVWG 176 Query: 181 RDASREQAIKDGYQAAASKEDFFAQADVLSLHLRLNDATRGIVTASDLARMKATACFVNT 240 +ASR++A++ GYQAAA K +FFA+ADVLSLHLRLNDATRGIVT DL MK + FVNT Sbjct: 177 SEASRQKALELGYQAAADKAEFFAKADVLSLHLRLNDATRGIVTKQDLLAMKPDSLFVNT 236 Query: 241 SRAELVEPDALEAALTAGRPGLAALDVYEREP-LPVESALLKMDNVVAAPHLGYVEKDGY 299 SRAELVE AL + + AA+DVYE EP LP LL + NV+ APHLGYVEK+ Y Sbjct: 237 SRAELVESGALYSVMQTNPTRQAAVDVYENEPALPNNEPLLSLPNVLCAPHLGYVEKNSY 296 Query: 300 ELYFRAAFQNIVAYAAGAPTHVLNPEA 326 E+YF+AAF+N+V +A A L+ +A Sbjct: 297 EIYFQAAFENVVKFAHSAAKASLSDKA 323 >APE1831 [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases Ape Aeropyrum pernix Length = 347 Score = 160 bits (404), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 105/268 (39%), Positives = 147/268 (54%), Gaps = 4/268 (1%) Query: 63 LLEKLPLLKLVSQTGKVSGHVDVAACTERGIAIVEGVGDPT-APAELTWALIMAAMRRVP 121 LL + P L++V+Q ++DV T GI + G T A AE TWALI+AA RRV Sbjct: 74 LLSQAPRLRIVAQMAVGFDNIDVECATRLGIYVTNTPGVLTEATAEFTWALILAAARRVV 133 Query: 122 QYCSALRAGAWQQVSPTPH-HNLIGTALKGRTLGIWGYGKIGRLVAGYGRAFGMQVLVWG 180 + +R G W ++ H ++G L+G+TLGI G G+IG VA G+AFGM+++ Sbjct: 134 EADHFVRWGEWWRLRTGWHPMMMLGVELRGKTLGILGMGRIGSRVAEIGKAFGMRIIYHS 193 Query: 181 RDASREQAIKDGYQAAASKEDFFAQADVLSLHLRLNDATRGIVTASDLARMKATACFVNT 240 R RE + G + S ED ++D+LS+HL L D TR ++ S+L MK TA VNT Sbjct: 194 RSRKREIEKELGAEYR-SLEDLLRESDILSIHLPLTDETRHLIGESELKLMKKTAILVNT 252 Query: 241 SRAELVEPDALEAALTAGRPGLAALDVYEREPLPVESALLKMDNVVAAPHLGYVEKDGYE 300 R +V+ AL AL G AALDV+E EPL L NVV APH ++ Sbjct: 253 GRGAIVDTGALVKALREGWIAAAALDVFEEEPLNPNHPLTAFKNVVLAPHAASATRETRL 312 Query: 301 LYFRAAFQNIVAYAAG-APTHVLNPEAL 327 A +N+VA+A G P +++N E + Sbjct: 313 RMAMMAAENLVAFAQGKVPPNLVNREVV 340 >MTH970 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases Mth Methanothermobacter thermautotrophicus Length = 525 Score = 150 bits (380), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 97/294 (32%), Positives = 158/294 (53%), Gaps = 11/294 (3%) Query: 32 NTIRGVGQLAARLSPFDAVVLIRERTALTRPLLEKLPLLKLVSQTGKVSGHVDVAACTER 91 NT +L + FDA+V +R RT +TR ++E P LK++++ G +VDV A T+R Sbjct: 29 NTTITPEELLDAIKDFDAIV-VRSRTKVTREVIEAAPRLKIIARAGVGVDNVDVKAATDR 87 Query: 92 GIAIVEGVGDPTAP-AELTWALIMAAMRRVPQYCSALRAGAWQQVSPTPHHNLIGTALKG 150 GI ++ + AE + L++A R++ +++ G W++ + +G L G Sbjct: 88 GIMVINAPESTSITVAEHSIGLMLALARKIAIADRSVKEGKWEK------NRFMGIELNG 141 Query: 151 RTLGIWGYGKIGRLVAGYGRAFGMQVLVWGRDASREQAIKDGYQAAASKEDFFAQADVLS 210 +TLGI G G+IG V +AFGM ++V+ S+E A + G E ++D+++ Sbjct: 142 KTLGIIGMGRIGSQVVVRTKAFGMDIMVYDPYISKEAAEEMGV-TVTDLETLLRESDIVT 200 Query: 211 LHLRLNDATRGIVTASDLARMKATACFVNTSRAELVEPDALEAALTAGRPGLAALDVYER 270 +H+ L TR +++ + MK TA VN +R +++ DAL AL G AALDV+E Sbjct: 201 IHVPLTPETRHLISEDEFKLMKDTAFIVNCARGGIIDEDALYRALKDGEIAGAALDVFEE 260 Query: 271 EPLPVESALLKMDNVVAAPHLGYVEKDGY-ELYFRAAFQNIVAYAAGAPTHVLN 323 EP P S LL+++NVV PH+G + + A + + GAP +VLN Sbjct: 261 EP-PEGSPLLELENVVLTPHIGASTSEAQRDAAIIVANEIKTVFQGGAPRNVLN 313 >BH1602 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases Bha Bacillus halodurans Length = 540 Score = 150 bits (379), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 89/279 (31%), Positives = 155/279 (55%), Gaps = 10/279 (3%) Query: 41 AARLSPFDAVVLIRERTALTRPLLEKLPLLKLVSQTGKVSGHVDVAACTERGIAIVEGV- 99 A L +DA+ L+R T +T L+EK+ LK++++ G ++D+ A T+ GI +V Sbjct: 50 ADDLHEYDAL-LVRSATTVTEELMEKMSSLKIIARAGVGVDNIDIDAATKHGIVVVNAPD 108 Query: 100 GDPTAPAELTWALIMAAMRRVPQYCSALRAGAWQQVSPTPHHNLIGTALKGRTLGIWGYG 159 G+ + AE T+A+I + +R++PQ ++++AG W++ + GT L+G+TLGI G+G Sbjct: 109 GNTISTAEHTFAMICSLLRKIPQANASIKAGEWKRKA------FQGTELRGKTLGIIGFG 162 Query: 160 KIGRLVAGYGRAFGMQVLVWGRDASREQAIKDGYQAAASKEDFFAQADVLSLHLRLNDAT 219 +IG +A +AF M V+ ++ +A K G AS +D AD++++H L T Sbjct: 163 RIGSQIAKRAKAFEMTPYVFDPFLTKARAEKLGV-TVASLDDVLQVADIITVHTPLTKET 221 Query: 220 RGIVTASDLARMKATACFVNTSRAELVEPDALEAALTAGRPGLAALDVYEREPLPVESAL 279 +G++ ++ + K +N +R +++ +AL+ L G AALDV+E EP+ E L Sbjct: 222 KGLLGMKNIGKTKKGVFLINCARGGIIDEEALKHYLREGHIAGAALDVFEEEPVADEE-L 280 Query: 280 LKMDNVVAAPHLGYVEKDGYELYFRAAFQNIVAYAAGAP 318 L DNV+A PH+ K+ Q ++ + G P Sbjct: 281 LAFDNVIATPHIAASTKEAQLNVAEQVSQEVLHFLEGNP 319