BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0017.0021.p         (157 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

RSc0016 [HE] COG0111 Phosphoglycerate dehydrogenase and related ...   183   2e-46
VCA0630 [HE] COG0111 Phosphoglycerate dehydrogenase and related ...   172   2e-43
MA1334 [HE] COG0111 Phosphoglycerate dehydrogenase and related d...   100   2e-21
PA2263 [CHR] COG1052 Lactate dehydrogenase and related dehydroge...    93   2e-19
BH3314 [CHR] COG1052 Lactate dehydrogenase and related dehydroge...    88   6e-18

>RSc0016 [HE] COG0111 Phosphoglycerate dehydrogenase and related
           dehydrogenases Rso Ralstonia solanacearum
          Length = 353

 Score =  183 bits (464), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 86/152 (56%), Positives = 109/152 (71%)

Query: 5   LFVWGRDASREQAIKDGYQAAASKEDFFAQADVLSLHLRLNDATRGIVTASDLARMKATA 64
           + VWGR+ S+E+A  DG+  A SK+  F Q+DVLS+HLRLND TRGIVT +DL RMK TA
Sbjct: 195 VLVWGRENSKERARADGFAVAESKDALFEQSDVLSVHLRLNDETRGIVTVADLTRMKPTA 254

Query: 65  CFVNTSRAELVEPDALEAALTAGRPGLAALDVYEREPLPVESALLKMDNVVAAPHLGYVE 124
            FVNTSRAELVE + +  AL  GRPG+AA+DV+E EP+     LL+M+N +  PH+GYVE
Sbjct: 255 LFVNTSRAELVEENGMVTALNRGRPGMAAIDVFETEPILQGHTLLRMENCICTPHIGYVE 314

Query: 125 KDGYELYFRAAFQNIVAYAAGAPTHVLNPEAL 156
           ++ YE+YF  AFQNI+    G    V NP AL
Sbjct: 315 RESYEMYFGIAFQNILDILQGNVDSVANPTAL 346


>VCA0630 [HE] COG0111 Phosphoglycerate dehydrogenase and related
           dehydrogenases Vch Vibrio cholerae
          Length = 323

 Score =  172 bits (437), Expect = 2e-43,   Method: Compositional matrix adjust.
 Identities = 87/143 (60%), Positives = 107/143 (74%), Gaps = 1/143 (0%)

Query: 5   LFVWGRDASREQAIKDGYQAAASKEDFFAQADVLSLHLRLNDATRGIVTASDLARMKATA 64
           + VWG +ASR++A++ GYQAAA K +FFA+ADVLSLHLRLNDATRGIVT  DL  MK  +
Sbjct: 172 ILVWGSEASRQKALELGYQAAADKAEFFAKADVLSLHLRLNDATRGIVTKQDLLAMKPDS 231

Query: 65  CFVNTSRAELVEPDALEAALTAGRPGLAALDVYEREP-LPVESALLKMDNVVAAPHLGYV 123
            FVNTSRAELVE  AL + +       AA+DVYE EP LP    LL + NV+ APHLGYV
Sbjct: 232 LFVNTSRAELVESGALYSVMQTNPTRQAAVDVYENEPALPNNEPLLSLPNVLCAPHLGYV 291

Query: 124 EKDGYELYFRAAFQNIVAYAAGA 146
           EK+ YE+YF+AAF+N+V +A  A
Sbjct: 292 EKNSYEIYFQAAFENVVKFAHSA 314


>MA1334 [HE] COG0111 Phosphoglycerate dehydrogenase and related
           dehydrogenases Mac Methanosarcina acetivorans str.C2A
          Length = 319

 Score = 99.8 bits (247), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 47/126 (37%), Positives = 79/126 (62%)

Query: 31  FFAQADVLSLHLRLNDATRGIVTASDLARMKATACFVNTSRAELVEPDALEAALTAGRPG 90
             +++D+++LH+ L   T  ++ A +LA+MK TA  +NT+R ++VE  AL  AL   +  
Sbjct: 192 LLSESDIVTLHVPLTPETEHMIGARELAKMKPTAILINTARGKVVEEAALMEALKEKKIA 251

Query: 91  LAALDVYEREPLPVESALLKMDNVVAAPHLGYVEKDGYELYFRAAFQNIVAYAAGAPTHV 150
            A LDV+EREPL ++S LL+M NVV  PH+ ++ ++  +     + +N+  +A G P +V
Sbjct: 252 GAGLDVFEREPLSMDSPLLEMHNVVLTPHIAFLSEESLDECTYISIENVEMFAKGKPQNV 311

Query: 151 LNPEAL 156
           +NP  L
Sbjct: 312 VNPSVL 317


>PA2263 [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases Pae
           Pseudomonas aeruginosa
          Length = 328

 Score = 93.2 bits (230), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 56/140 (40%), Positives = 82/140 (58%), Gaps = 2/140 (1%)

Query: 18  IKDGYQAAASKED-FFAQADVLSLHLRLNDATRGIVTASDLARMKATACFVNTSRAELVE 76
           +++ Y A+    D    ++D + L L L  AT G++ A+  ARM+  A F+N SR  +V+
Sbjct: 182 VEERYAASYRPLDALLEESDFVCLTLPLTAATEGLIGAAQFARMRPQAIFINISRGRVVD 241

Query: 77  PDALEAALTAGRPGLAALDVYEREPLPVESALLKMDNVVAAPHLGYVEKDGYELYFRAAF 136
             AL  AL   R   A LDV+EREPL  +S LL++ NVVA PH+G   ++  E   R A 
Sbjct: 242 EAALIEALAQRRIRAAGLDVFEREPLSPDSPLLRLPNVVATPHIGSATEETREAMARCAV 301

Query: 137 QNIVAYAAGA-PTHVLNPEA 155
            N++A  AGA P +++NP A
Sbjct: 302 DNLLAALAGARPLNLVNPSA 321


>BH3314 [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases Bha
           Bacillus halodurans
          Length = 324

 Score = 88.2 bits (217), Expect = 6e-18,   Method: Compositional matrix adjust.
 Identities = 54/143 (37%), Positives = 77/143 (53%), Gaps = 1/143 (0%)

Query: 15  EQAIKDGYQAAASKEDFFAQADVLSLHLRLNDATRGIVTASDLARMKATACFVNTSRAEL 74
           EQA K+      S +   A++D + L     D TR ++  +   +MK+TA F+NTSR   
Sbjct: 180 EQAEKELGATYCSLDHLLARSDYVVLLAPSTDETRKMMGPAQFQKMKSTAHFINTSRGTN 239

Query: 75  VEPDALEAALTAGRPGLAALDVYEREPLPVESALLKMDNVVAAPHLGYVEKDGYELYFRA 134
           V+  AL  ALT G    A LDVYE+EP+  +  L+++ NVVA PH+G  E        R 
Sbjct: 240 VDEQALYRALTEGWIAGAGLDVYEKEPISADHPLVQLPNVVALPHIGSAEVGTRREMVRL 299

Query: 135 AFQNIVAYAAGAP-THVLNPEAL 156
           A +N++    G   TH+ NPE L
Sbjct: 300 AIENLLLGIKGKSLTHIANPEVL 322