BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0017.0007.p (402 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BMEII0291 [R] COG0579 Predicted dehydrogenase Bme Brucella melit... 347 3e-95 SMb20101 [R] COG0579 Predicted dehydrogenase Sme Sinorhizobium m... 329 8e-90 alr2826 [R] COG0579 Predicted dehydrogenase Nos Nostoc sp. PCC 7120 322 1e-87 ZygaF [R] COG0579 Predicted dehydrogenase EcZ Escherichia coli O... 298 1e-80 ECs3521 [R] COG0579 Predicted dehydrogenase Ecs Escherichia coli... 297 3e-80 >BMEII0291 [R] COG0579 Predicted dehydrogenase Bme Brucella melitensis Length = 410 Score = 347 bits (890), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 174/399 (43%), Positives = 251/399 (62%), Gaps = 4/399 (1%) Query: 1 MKPLRYAVIGGGINGLAVARQLLLDDPDVRVTVFEKEEAVAQHQSSHNSGVVHAGLYYEP 60 M Y VIGGGI GLA A+ + +P R+ V EKE +A+HQ+ HNSGV+HAG+YY+P Sbjct: 1 MADYDYCVIGGGIVGLATAKAVQEAEPGARIIVLEKESGLARHQTGHNSGVIHAGIYYQP 60 Query: 61 GGLKATLCRRGVELVKRYCEQNALPYDECGKVVVALGEEELPRLDAIYRKALANGVPDVE 120 G LKA LCR G + K +C+Q ++P++ CGK++VA E+ R++A+ R+A+ N + + Sbjct: 61 GSLKARLCRAGAQATKAFCKQYSIPFESCGKLLVATSALEMERMEALARRAVQNNI-EFS 119 Query: 121 MIDAARLREIEPNCVGLRALYSPRTAIVSYGQIAQRMAQEIEERGGTIRLNAPVQRVIER 180 +D LR+ EP GL AL+ P T IV Y ++++ MA EI ERGG +RLN+PV + E Sbjct: 120 HLDQQALRKAEPAISGLGALFVPATGIVDYAKVSRAMAAEIVERGGIVRLNSPVTAIHE- 178 Query: 181 GDQVHIELQSGEMHPEAFDSAIACSGLQSDRLAQQSGDAATPRIVPFFGQYYVIDEAYKS 240 D+ +E+ SG A +AC+GLQSDR+A+ +G T RIVPF G+YY + + Sbjct: 179 -DEKGVEVVSGGETVRA-SKLVACAGLQSDRIARLAGLDITHRIVPFRGEYYTLPQTRAG 236 Query: 241 HVKGLIYPVPDPRFPFLGVHFTKRIDGQMTIGPNAFISLGRENYHGDRFSLRDIADYLSY 300 V+ LIYP+PDP PFLG+H T+ IDG +T+GPNA + RE Y F DIAD + Sbjct: 237 IVRHLIYPIPDPDLPFLGIHLTRTIDGGVTVGPNAVLGFSREGYAKGSFHPGDIADMSFF 296 Query: 301 PGFWKFASRNVPATLRELKTVVSERIFVREAARYVPALAEVGVTPAVRGIRAQAMESNGR 360 GFWK A +N + + E S ++++ +Y P+L + GIRAQA+ +G Sbjct: 297 AGFWKMAMKNWRSAISEFGNSTSRARYLKQCRKYCPSLELSDLGAPGAGIRAQAVLDDGT 356 Query: 361 LVDDFVIRQSSRVTHIRNAPSPGATSSLAIGEHIVRNLI 399 LV DF+ +++ R+ H+ NAPSP ATSS+ IG I + L+ Sbjct: 357 LVHDFLFKETERMLHVCNAPSPAATSSIPIGRMIAQKLL 395 >SMb20101 [R] COG0579 Predicted dehydrogenase Sme Sinorhizobium meliloti Length = 426 Score = 329 bits (843), Expect = 8e-90, Method: Compositional matrix adjust. Identities = 165/394 (41%), Positives = 234/394 (59%), Gaps = 4/394 (1%) Query: 6 YAVIGGGINGLAVARQLLLDDPDVRVTVFEKEEAVAQHQSSHNSGVVHAGLYYEPGGLKA 65 Y +IGGGI GLA A L + + EKE +A+HQ+ HNSGV+HAG+YY PG LKA Sbjct: 15 YCIIGGGIVGLATAMALQERMGGASIVLLEKERELARHQTGHNSGVIHAGIYYAPGSLKA 74 Query: 66 TLCRRGVELVKRYCEQNALPYDECGKVVVALGEEELPRLDAIYRKALANGVPDVEMIDAA 125 LCR G E K +C N + ++ CGK++VA + E+ R++++ +A NG+ + + + Sbjct: 75 KLCREGAEATKEFCTGNGISFETCGKLLVATNDAEIERMESLEERAQQNGI-EYTRLSKS 133 Query: 126 RLREIEPNCVGLRALYSPRTAIVSYGQIAQRMAQEIEERGGTIRLNAPVQRVIERGDQVH 185 +LR EPN GL AL T IV Y + + MA+ IE RGG IR + E V Sbjct: 134 QLRSDEPNIAGLSALLVHATGIVDYSAVCRAMAERIEVRGGEIRCGVEATAIAEEDGGVR 193 Query: 186 IELQSGEMHPEAFDSAIACSGLQSDRLAQQSGDAATPRIVPFFGQYYVIDEAYKSHVKGL 245 I +G + IAC+GLQSDR+A +G + RIVPF G+YYV+ + + L Sbjct: 194 IASATGRIEARRL---IACAGLQSDRIALMAGLSIDHRIVPFRGEYYVLPASKAGVTRRL 250 Query: 246 IYPVPDPRFPFLGVHFTKRIDGQMTIGPNAFISLGRENYHGDRFSLRDIADYLSYPGFWK 305 IYP+PDP PFLG+H T+ IDG MT+GPNA + RE Y F D+A+ ++PGFWK Sbjct: 251 IYPIPDPNLPFLGIHLTRTIDGGMTVGPNAVLGFAREGYPKGSFKAADVANMAAFPGFWK 310 Query: 306 FASRNVPATLRELKTVVSERIFVREAARYVPALAEVGVTPAVRGIRAQAMESNGRLVDDF 365 A++N + + E S ++RE +Y P+L + GIRAQA+ ++G LV DF Sbjct: 311 MAAKNWRSAITEFANSASRFRYLRECRKYCPSLTIDDLAVPQAGIRAQAVMADGSLVHDF 370 Query: 366 VIRQSSRVTHIRNAPSPGATSSLAIGEHIVRNLI 399 + +Q+ R+ H+ NAPSP ATS++ IG IV L+ Sbjct: 371 LFKQTERMLHVCNAPSPAATSAIPIGRMIVDRLL 404 >alr2826 [R] COG0579 Predicted dehydrogenase Nos Nostoc sp. PCC 7120 Length = 404 Score = 322 bits (824), Expect = 1e-87, Method: Compositional matrix adjust. Identities = 164/392 (41%), Positives = 236/392 (60%), Gaps = 10/392 (2%) Query: 6 YAVIGGGINGLAVARQLLLDDPDVRVTVFEKEEAVAQHQSSHNSGVVHAGLYYEPGGLKA 65 + ++GGGI GL+ L P R+ V EKE A HQ+ +NSGV+H+G+YY+PG KA Sbjct: 4 FTIVGGGIVGLSTGMALGKRYPQARILVLEKESQWAFHQTGNNSGVIHSGIYYKPGSFKA 63 Query: 66 TLCRRGVELVKRYCEQNALPYDECGKVVVALGEEELPRLDAIYRKALANGVPDVEMIDAA 125 CR G + + ++C+ + ++ CGKV+VA E+ELPRL+ +Y++ L NG V+ I A Sbjct: 64 KFCRDGRDSMVKFCQDYGIDHEVCGKVIVATNEQELPRLENLYQRGLENGT-QVQKISAE 122 Query: 126 RLREIEP--NCV-GLRALYSPRTAIVSYGQIAQRMAQEIEERGGTIRLNAPVQRVIERGD 182 ++EIEP CV G+R T IV+Y Q+ + + I+++GG +RLN V ++ G+ Sbjct: 123 EVKEIEPYVKCVAGIRVF---STGIVNYKQVCLKYVELIQQQGGDLRLNTKVLKISPSGN 179 Query: 183 QVHIELQSGEMHPEAFDSAIACSGLQSDRLAQQSGDAATPRIVPFFGQYYVIDEAYKSHV 242 +E +G I C+GL SDR+A+ G + +IVPF G+YY + + V Sbjct: 180 NHVLETNNGNFETRF---VINCAGLHSDRIAKLGGVKPSAKIVPFRGEYYELTPEKRYLV 236 Query: 243 KGLIYPVPDPRFPFLGVHFTKRIDGQMTIGPNAFISLGRENYHGDRFSLRDIADYLSYPG 302 K LIYPVP+P FPFLGVHFT+ IDG + GPNA +SL RE Y F LRD A+ ++YPG Sbjct: 237 KTLIYPVPNPEFPFLGVHFTRMIDGSVHAGPNAVLSLKREGYKKTDFDLRDFAEVMTYPG 296 Query: 303 FWKFASRNVPATLRELKTVVSERIFVREAARYVPALAEVGVTPAVRGIRAQAMESNGRLV 362 FWK A ++ ++E+ S+ F R +P + + P G+RAQA+ +G+LV Sbjct: 297 FWKLAGKHADEGIQEIIRSFSKAAFTRSLQNLIPEVQAEDLVPTHAGVRAQALMDDGKLV 356 Query: 363 DDFVIRQSSRVTHIRNAPSPGATSSLAIGEHI 394 DDF I H+ NAPSP ATSSL IG+ I Sbjct: 357 DDFYIVPGENSIHVCNAPSPAATSSLEIGKAI 388 >ZygaF [R] COG0579 Predicted dehydrogenase EcZ Escherichia coli O157:H7 EDL933 Length = 444 Score = 298 bits (763), Expect = 1e-80, Method: Compositional matrix adjust. Identities = 153/380 (40%), Positives = 222/380 (58%), Gaps = 3/380 (0%) Query: 16 LAVARQLLLDDPDVRVTVFEKEEAVAQHQSSHNSGVVHAGLYYEPGGLKATLCRRGVELV 75 ++ A QL+ PD R+ + EKE A HQ+ HNSGV+HAG+YY PG LKA C G Sbjct: 36 MSTAMQLIDVYPDARIALLEKESGPACHQTGHNSGVIHAGVYYTPGSLKAQFCLAGNRAT 95 Query: 76 KRYCEQNALPYDECGKVVVALGEEELPRLDAIYRKALANGVPDVEMIDAARLREIEPNCV 135 K +C+QN + YD CGK++VA E E+ R+ A++ + ANG+ + E ++A LRE EPN Sbjct: 96 KAFCDQNGIRYDNCGKMLVATSELEMERMRALWERTAANGI-EREWLNADELREREPNIT 154 Query: 136 GLRALYSPRTAIVSYGQIAQRMAQEIEERGGTIRLNAPVQRVIERGDQVHIELQSGEMHP 195 GL ++ P + IVSY ++ MA+ + RGG I NA V + E V I + G + Sbjct: 155 GLGGIFVPSSGIVSYREVTAAMAKIFQARGGEIIYNAEVSGLSEHKSGVVIRTRQGSDYE 214 Query: 196 EAFDSAIACSGLQSDRLAQQSGDAATPRIVPFFGQYYVIDEAYKSHVKGLIYPVPDPRFP 255 + + I+CSGL +DRL + G I PF G+Y+ + + V LIYP+PDP P Sbjct: 215 AS--TLISCSGLMADRLVKMXGLEPGFIICPFRGEYFRLAPEHNQIVNHLIYPIPDPAMP 272 Query: 256 FLGVHFTKRIDGQMTIGPNAFISLGRENYHGDRFSLRDIADYLSYPGFWKFASRNVPATL 315 FLGVH T+ IDG +T+GPNA ++ RE Y FS D + L G + ++ + L Sbjct: 273 FLGVHLTRMIDGSVTVGPNAVLAFKREGYRKRDFSFSDTLEILGSSGIRRVLQNHLRSGL 332 Query: 316 RELKTVVSERIFVREAARYVPALAEVGVTPAVRGIRAQAMESNGRLVDDFVIRQSSRVTH 375 E+K + + ++R +Y P L+ + P G+RAQA+ +G+L+DDF+ + R H Sbjct: 333 GEMKNSLCKSGYLRLVQKYCPRLSLSDLQPWPAGVRAQAVSPDGKLIDDFLFVTTPRTIH 392 Query: 376 IRNAPSPGATSSLAIGEHIV 395 NAPSP ATS++ IG HIV Sbjct: 393 TCNAPSPAATSAIPIGAHIV 412 >ECs3521 [R] COG0579 Predicted dehydrogenase Ecs Escherichia coli O157:H7 Length = 444 Score = 297 bits (761), Expect = 3e-80, Method: Compositional matrix adjust. Identities = 153/380 (40%), Positives = 222/380 (58%), Gaps = 3/380 (0%) Query: 16 LAVARQLLLDDPDVRVTVFEKEEAVAQHQSSHNSGVVHAGLYYEPGGLKATLCRRGVELV 75 ++ A QL+ PD R+ + EKE A HQ+ HNSGV+HAG+YY PG LKA C G Sbjct: 36 MSTAMQLIDVYPDARIALLEKESGPACHQTGHNSGVIHAGVYYTPGSLKAQFCLAGNRAT 95 Query: 76 KRYCEQNALPYDECGKVVVALGEEELPRLDAIYRKALANGVPDVEMIDAARLREIEPNCV 135 K +C+QN + YD CGK++VA E E+ R+ A++ + ANG+ + E ++A LRE EPN Sbjct: 96 KAFCDQNGIRYDNCGKMLVATSELEMERMRALWERTAANGI-EREWLNADELREREPNIT 154 Query: 136 GLRALYSPRTAIVSYGQIAQRMAQEIEERGGTIRLNAPVQRVIERGDQVHIELQSGEMHP 195 GL ++ P + IVSY ++ MA+ + RGG I NA V + E V I + G + Sbjct: 155 GLGGIFVPSSGIVSYREVTAAMAKIFQARGGEIIYNAEVSGLSEHKSGVVIRTRQGSDYE 214 Query: 196 EAFDSAIACSGLQSDRLAQQSGDAATPRIVPFFGQYYVIDEAYKSHVKGLIYPVPDPRFP 255 + + I+CSGL +DRL + G I PF G+Y+ + + V LIYP+PDP P Sbjct: 215 AS--TLISCSGLMADRLVKMLGLEPGFIICPFRGEYFRLAPEHNQIVNHLIYPIPDPAMP 272 Query: 256 FLGVHFTKRIDGQMTIGPNAFISLGRENYHGDRFSLRDIADYLSYPGFWKFASRNVPATL 315 FLGVH T+ IDG +T+GPNA ++ RE Y FS D + L G + ++ + L Sbjct: 273 FLGVHLTRMIDGSVTVGPNAVLAFKREGYRKRDFSFSDTLEILGSSGIRRVLQNHLRSGL 332 Query: 316 RELKTVVSERIFVREAARYVPALAEVGVTPAVRGIRAQAMESNGRLVDDFVIRQSSRVTH 375 E+K + + ++R +Y P L+ + P G+RAQA+ +G+L+DDF+ + R H Sbjct: 333 GEMKNSLCKSGYLRLVQKYCPRLSLSDLQPWPAGVRAQAVSPDGKLIDDFLFVTTPRTIH 392 Query: 376 IRNAPSPGATSSLAIGEHIV 395 NAPSP ATS++ IG HIV Sbjct: 393 TCNAPSPAATSAIPIGAHIV 412