BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0016.0078.p (350 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value FN0543 [M] COG0859 ADP-heptose Fnu Fusobacterium nucleatum 87 6e-17 NMB1527 [M] COG0859 ADP-heptose Nme Neisseria meningitidis MC58 87 7e-17 NMA1727 [M] COG0859 ADP-heptose NmA Neisseria meningitidis Z2491 86 1e-16 aq_145 [M] COG0859 ADP-heptose Aae Aquifex aeolicus 81 4e-15 PM1294 [M] COG0859 ADP-heptose Pmu Pasteurella multocida 80 5e-15 >FN0543 [M] COG0859 ADP-heptose Fnu Fusobacterium nucleatum Length = 345 Score = 87.0 bits (214), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 74/304 (24%), Positives = 133/304 (43%), Gaps = 25/304 (8%) Query: 6 KHILISRTDNIGDIILTLPMAARLKQINPGVRISLLCRRYASDVVRYSDAIDE-VVEEES 64 K IL+SRTD IGD++L++P LK++ P + ++ R+Y D+V+ ID V+ +E Sbjct: 10 KRILVSRTDKIGDLVLSIPSFFMLKKMYPNAELVVIVRKYNVDIVKNLPYIDRIVIIDEY 69 Query: 65 VVNDLYGFLRGSDIDTVILAQPNHALARAAFFARIKHRIGNAQQKIYQLLYCNDRVRFRK 124 +L + D I + +A A ++ K +IG K+ N V ++ Sbjct: 70 SKAELLEKIAYFKADVFIALYNDSYIASLARASKAKIKIG-PISKLSSFFTYNKGVLQKR 128 Query: 125 GISPNHEAQINFEFLKPYGDSTIPTREEIPDYYRFS---IPPDQDIAAA---FQPHEF-- 176 +S +E Q N + + T R+ Y + I D++ A F+ + Sbjct: 129 SLSLKNEGQYNLDLV------TKLDRKRFAILYELNTKLILTDENKKVADVYFKENSIEG 182 Query: 177 -NLILHPKSNGHGREWPVDHYVSLAEKLTET-PGLRMWITGSAEEGKWLEEHAAPL---L 231 L+++P G + + Y+S+ +K+ E P L + IT + EE L + Sbjct: 183 KTLVVNPFIGGSAKNITDEQYISILKKIKEKMPDLNIIITSYTTD----EERTEKLCKDI 238 Query: 232 AMPHVVNTCGSMSLSRLTQFISQADGLVASGTGPLHLSAAIGQNTLGLFPPTRPMHAGRW 291 + S+ I +AD + TGP H++ A+G+ + ++P + RW Sbjct: 239 GKDKIFAFSNGASILNTASIIDRADVYFGASTGPTHIAGALGKKIVAIYPHKKTQSPTRW 298 Query: 292 AALG 295 LG Sbjct: 299 GVLG 302 >NMB1527 [M] COG0859 ADP-heptose Nme Neisseria meningitidis MC58 Length = 336 Score = 87.0 bits (214), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 86/350 (24%), Positives = 148/350 (42%), Gaps = 35/350 (10%) Query: 5 SKHILISRTDNIGDIILTLPMAARLKQINPGVRISLLCRRYASDVVRYSDAIDEVVEEES 64 S ILI IGD ++T P+ RLK+++PG I + +++ V ++E++E Sbjct: 2 SIKILIISPSWIGDCVMTQPLFRRLKELHPGCTIDVFAPKWSMAVFERMPEVNEILENSF 61 Query: 65 VVNDLYGFLR---GSDI-----DTVILAQPNHALARAAFFARIKHRIGNAQQKIYQLLYC 116 L R G D+ D VI+ + A A I R G + Y LL Sbjct: 62 GHGALELKRRWRVGRDLGRRGYDQVIVLPGSLKSAIIALATGIGKRTGYVGESRYFLL-- 119 Query: 117 NDRVRFRKGISP---------NHEAQINFEFLKPYGDSTIPTREEIPDYYRFSIPPDQDI 167 ND R K P H +Q +F+ + + +I R F + + + Sbjct: 120 NDIRRLDKERLPLMVDRYTALAHPSQEDFDGHSGFPEFSIDERRREISVETFGLDIGKPV 179 Query: 168 AAAFQPHEFNLILHPKSNGHGREWPVDHYVSLAEKLTETPGLRMWITGSAEEGKWLEEHA 227 A EF G + WP H+ L + G ++W+ GS ++ + EE Sbjct: 180 LAFCPGAEF---------GPAKRWPTRHFAELGKHYL-AAGWQVWLFGSQKDDEIAEE-- 227 Query: 228 APLLAMPHVVNTCGSMSLSRLTQFISQADGLVASGTGPLHLSAAIGQNTLGLFPPTRPMH 287 L+ VN CG LS+ +S AD +V + +G +HL+AA+G+ + ++ + P H Sbjct: 228 INRLSDGMCVNLCGKTDLSQAMDLLSLADTVVCNDSGLMHLAAALGRKVVAVYGSSSPTH 287 Query: 288 AGRWAALGKRASNLTTDQPSCPGCER-LRIMTCDCMRAISPDSVLQTIQD 336 L RA ++ P +R + DC+ + P+ ++Q +++ Sbjct: 288 T---PPLSDRAKIVSLHLECSPCFKRECPLGHTDCLNRLYPEKIVQAVEE 334 >NMA1727 [M] COG0859 ADP-heptose NmA Neisseria meningitidis Z2491 Length = 336 Score = 85.9 bits (211), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 85/350 (24%), Positives = 149/350 (42%), Gaps = 35/350 (10%) Query: 5 SKHILISRTDNIGDIILTLPMAARLKQINPGVRISLLCRRYASDVVRYSDAIDEVVEEES 64 S ILI IGD ++T P+ RLK+++PG I + +++ V ++E++E Sbjct: 2 SIKILIISPSWIGDCVMTQPLFRRLKELHPGCTIDVFAPKWSMAVFERMPEVNEILENPF 61 Query: 65 VVNDLYGFLR---GSDI-----DTVILAQPNHALARAAFFARIKHRIGNAQQKIYQLLYC 116 L R G D+ D VI+ + A A I R G + Y LL Sbjct: 62 GHGALELKRRWRVGRDLGRRGYDQVIVLPGSLKSAIIALATGIGKRTGYVGESRYFLL-- 119 Query: 117 NDRVRFRKGISP---------NHEAQINFEFLKPYGDSTIPTREEIPDYYRFSIPPDQDI 167 ND R K P H +Q +F+ + + +I R F + + + Sbjct: 120 NDIRRLDKERLPLMVDRYTALAHPSQEDFDGHSGFPEFSIDERRREISVETFGLDIGKPV 179 Query: 168 AAAFQPHEFNLILHPKSNGHGREWPVDHYVSLAEKLTETPGLRMWITGSAEEGKWLEEHA 227 A EF G + WP ++ L + + G ++W+ GS ++ + EE Sbjct: 180 LAFCPGAEF---------GPAKRWPTRYFAELGKHYSAA-GWQVWLFGSQKDDEIAEE-- 227 Query: 228 APLLAMPHVVNTCGSMSLSRLTQFISQADGLVASGTGPLHLSAAIGQNTLGLFPPTRPMH 287 L+ VN CG LS+ +S AD +V + +G +HL+AA+G+ + ++ + P H Sbjct: 228 INCLSDGMCVNLCGKTDLSQAMDLLSLADTVVCNDSGLMHLAAALGRKVVAVYGSSSPTH 287 Query: 288 AGRWAALGKRASNLTTDQPSCPGCER-LRIMTCDCMRAISPDSVLQTIQD 336 L RA ++ P +R + DC+ + P+ ++Q +++ Sbjct: 288 T---PPLSDRAKIVSLHLECSPCFKRECPLGHTDCLNRLYPEKIVQAVEE 334 >aq_145 [M] COG0859 ADP-heptose Aae Aquifex aeolicus Length = 317 Score = 80.9 bits (198), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 83/344 (24%), Positives = 147/344 (42%), Gaps = 43/344 (12%) Query: 8 ILISRTDNIGDIILTLPMAARLKQINPGVRISLLCRRYASDVVRYSDAIDEVVEEESVVN 67 ILI +T +GD++L P+ LK+ P +I + R + ++ + D E++ Sbjct: 3 ILIWQTAYLGDVVLATPLIQTLKKNFPDAKIGFVGRPFIKEL--FKDEEVELIPYSKKFK 60 Query: 68 DLYGFLRG-SDIDTVILAQPNHALARAAFFARIKHRIGNAQQKIYQLLYCNDRVRFRKGI 126 + + +R + D VI + A FF+ IK RIG + + LY + Sbjct: 61 ESFTVIRKIKNYDVVISPHRSMRTALILFFSGIKERIGFDRSDL-PFLYTK--------L 111 Query: 127 SPN----HEAQINFEFLKPYG------DSTIPTREEIPDYYRFSIPPDQDIAAAFQPHEF 176 P+ HE N E LKP G ++ + +EE +Y + I F E Sbjct: 112 VPHRWELHEVDRNLELLKPLGVKEFIRETKLKMKEE--EY--------RKILNKFNLKEK 161 Query: 177 N-LILHPKSNGHGREWPVDHYVSLAEKLTETPGLRMWITGSAEEGKWLEEHAAPLLAMPH 235 +++ P SN +EW + ++ L KL TP + ITG+ E +E + + + Sbjct: 162 KYIVISPFSNFPLKEWSLKNWKELVRKLN-TPVV---ITGTKE-----DEERSKEIDGKN 212 Query: 236 VVNTCGSMSLSRLTQFISQADGLVASGTGPLHLSAAIGQNTLGLFPPTRPMHAGRWAALG 295 VVN G SL + A +++ + +H++ A L ++ T P + G + +G Sbjct: 213 VVNLVGKTSLREFMGVLKGAKFAISNDSSAVHVANAFRVPALTIYTATSPKY-GFYPLIG 271 Query: 296 KRASNLTTDQPSCPGCERLRIMTCDCMRAISPDSVLQTIQDWIS 339 + N P P ++ + T +C+ PD VL+ +I Sbjct: 272 EYIQNPAPCSPCSPNPKKCKTGTKECLYFPEPDYVLEKAIPYIK 315 >PM1294 [M] COG0859 ADP-heptose Pmu Pasteurella multocida Length = 348 Score = 80.5 bits (197), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 78/302 (25%), Positives = 128/302 (42%), Gaps = 22/302 (7%) Query: 6 KHILISRTDNIGDIILTLPMAARLKQINPGVRISLLCRRYASDVVRYSDAIDEVV----E 61 + +L+ R D +GD +L P A LKQ NP ++++ L Y +D+ R +D+V+ + Sbjct: 2 QKLLVVRNDKLGDFMLAWPAFAMLKQSNPSLKLTALVPNYTADLARLCPYLDDVIIDVGK 61 Query: 62 EESVVNDLYGF--LRGSDIDTVILAQPNHALARAAFFARIKHRIGNAQQKIYQLLYCNDR 119 + + L ++ D I + A + A I R+ A K+ Q LY N R Sbjct: 62 KADKADQLKTLQAIKAVKFDASINFFSDKYNALLVWKAGIPFRLAPA-TKLIQFLY-NHR 119 Query: 120 VRFRKGISPNHEAQINFEFLKPYGDST-IPTREEIPDYYRFSIPP--------DQDIAAA 170 V R+ S E + N + + + T P E P Y F Q + A Sbjct: 120 VTQRRSKSLKPEFEYNLDLARAFLQKTHCPIVEPTPPYLTFEQNAVQHQREMLSQTLGLA 179 Query: 171 FQPHEFNLILHPKSNGHGREWPVDHYVSLAEKLTETPGLRMWITGSAEEGKWLEEHA-AP 229 + + +H S G ++ Y L L ++ +T E + + H+ A Sbjct: 180 LEKKW--IFVHSGSGGSATNLSLEQYAQLILGLLSQFDCQIVLTAGPNESE--KAHSLAN 235 Query: 230 LLAMPHVVNTCGSMSLSRLTQFISQADGLVASGTGPLHLSAAIGQNTLGLFPPTRPMHAG 289 L+ +VV + L + ++ AD +A TGPLHLSAA+ T+G +P R Sbjct: 236 LVNHHNVVVYDKNAGLVDFARSLACADLFIAGSTGPLHLSAALNIPTIGFYPSRRSATPL 295 Query: 290 RW 291 RW Sbjct: 296 RW 297