BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0016.0029.p (416 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BMEII0141 [C] COG1012 NAD-dependent aldehyde dehydrogenases Bme ... 293 5e-79 MA4079 [C] COG1012 NAD-dependent aldehyde dehydrogenases Mac Met... 276 6e-74 feaB [C] COG1012 NAD-dependent aldehyde dehydrogenases Eco Esche... 275 1e-73 FN0454 [C] COG1012 NAD-dependent aldehyde dehydrogenases Fnu Fus... 271 3e-72 STM1597 [C] COG1012 NAD-dependent aldehyde dehydrogenases Sty Sa... 255 1e-67 >BMEII0141 [C] COG1012 NAD-dependent aldehyde dehydrogenases Bme Brucella melitensis Length = 271 Score = 293 bits (750), Expect = 5e-79, Method: Compositional matrix adjust. Identities = 145/270 (53%), Positives = 184/270 (68%) Query: 66 EVVFEDETRRDELHRKPYGVIAAIAPWNWPLMISIWQVIPALYAGNTVVLKPSEYTSVCG 125 EVV +D R E+HRKP GV +I PWNWP+MI+ W +IPA+ GNTVV+KPS T + Sbjct: 2 EVVQDDNEGRVEIHRKPIGVTGSITPWNWPVMIACWHIIPAVRTGNTVVIKPSPLTPLST 61 Query: 126 LELARVVADALPPGVLNTVSGDGSVGAMLVEDGDVNKIMFTGSGATGARIVAAAARNLTP 185 + L ++ + LP GV+N V+G+ S+GA L + K+ FTGS TG +I+A+AA L Sbjct: 62 IRLVEIINEVLPAGVVNVVTGENSIGAALSAHPGIAKMTFTGSTETGRKIMASAAATLKR 121 Query: 186 TTMELGGNDAAIVLDDADPKAIAPGLFWGAFLNMGQTCACAKRLYVPDALHDQIVDELKA 245 T+ELGGNDA IVL DADP IA GLFWGAF+N GQTCA KRLYV D ++D + L Sbjct: 122 LTLELGGNDAGIVLPDADPARIAEGLFWGAFINSGQTCAALKRLYVHDHIYDDVCRHLTE 181 Query: 246 IIAALPMGDGLQPGIAMGPVQNPMQLKKVVALVESAREEGGTIVCGGVLPDGPGNFYPLT 305 A + +GDGL +G VQN MQ KV LV+ AR +G I+ GG +GPG FYP+T Sbjct: 182 YAANIIIGDGLDEKSVLGLVQNAMQFNKVRELVDDARAKGARILIGGEAAEGPGYFYPIT 241 Query: 306 LVTGLRDGARLVDEEQFGPVLPIIRYSDLE 335 LV + +G RLVDEEQFGPVLPIIRYSD++ Sbjct: 242 LVADIDNGTRLVDEEQFGPVLPIIRYSDID 271 >MA4079 [C] COG1012 NAD-dependent aldehyde dehydrogenases Mac Methanosarcina acetivorans str.C2A Length = 479 Score = 276 bits (707), Expect = 6e-74, Method: Compositional matrix adjust. Identities = 166/423 (39%), Positives = 238/423 (56%), Gaps = 17/423 (4%) Query: 2 QRREYLNRVADAIAANAERLATLVTQEQGRPLGGVGPGQVPGSRFELWGCEAWTRATASL 61 QR E L R A+ + + LA+L+TQEQG+P + +R E+ G L Sbjct: 64 QRGEVLYRAAEIVRQRKDELASLLTQEQGKP--------IVEARNEIEGFAHVLEYYCGL 115 Query: 62 ELAPEVVFEDETRRDELH--RKPYGVIAAIAPWNWPLMISIWQVIPALYAGNTVVLKPSE 119 + F +KP GV AAI PWN P +I W++ P L +GNT+VLKP+ Sbjct: 116 SGSQRGDFIPVPGNGYAFTVKKPLGVCAAIIPWNMPALIMGWKIAPVLISGNTLVLKPAS 175 Query: 120 YTSVCGLELARVVADA-LPPGVLNTVSGDG-SVGAMLVEDGDVNKIMFTGSGATGARIVA 177 T + L LA + +A LP GVLN V+G G +VG LV +V KI FTG TG R+ Sbjct: 176 NTPLTNLTLASIFVEAGLPAGVLNVVTGPGETVGESLVRSPEVRKISFTGEARTGKRVAE 235 Query: 178 AAARNLTPTTMELGGNDAAIVLDDADPKAIAPGLFWGAFLNMGQTCACAKRLYVPDALHD 237 AA + T+ELGG+D +V DDAD ++ A G G F N GQTC KRLYV +++ + Sbjct: 236 LAACGMKRITLELGGSDPMLVCDDADLESAAAGALRGRFYNCGQTCTAVKRLYVFESVAE 295 Query: 238 QIVDELKAIIAALPMGDGLQPGIAMGPVQNPMQLKKVVALV-ESAREEGGTIVCGGVLPD 296 + + +L+ I +L +G+G+ I+MGP+ N Q + + L E ++ G I+ GG +P+ Sbjct: 296 EFIKKLETGIKSLRLGNGMDKNISMGPLNNRTQWEYIKELAAEIEEKDAGRIITGGKVPE 355 Query: 297 ----GPGNFYPLTLVTGLRDGARLVDEEQFGPVLPIIRYSDLEQAIANANRLDVGLGASV 352 G F+ TLV+ + +RL+ EE FGP+LP++ +L++AI AN GLGAS+ Sbjct: 356 FKDSEKGYFFEPTLVSDVPGDSRLLKEEVFGPLLPVVTVKNLDEAIVGANSTCYGLGASI 415 Query: 353 WSSDSQRAAQVATRLQAGTVWVNQHGMVHPMVPFGGNKRSGWGVEFGQEGLKGVTQPQVI 412 W+ + RA + +L AG +W+NQH V P VPFGG K SG+G E G E L + + I Sbjct: 416 WTKNIDRARKGCEQLNAGIIWINQHLKVAPEVPFGGVKESGFGRENGPESLSEYLETKTI 475 Query: 413 SLK 415 LK Sbjct: 476 MLK 478 >feaB [C] COG1012 NAD-dependent aldehyde dehydrogenases Eco Escherichia coli K12 Length = 500 Score = 275 bits (704), Expect = 1e-73, Method: Compositional matrix adjust. Identities = 165/424 (38%), Positives = 238/424 (56%), Gaps = 17/424 (4%) Query: 2 QRREYLNRVADAIAANAERLATLVTQEQGRPLGGVGPGQVPGSRFELWGCEAWTRATASL 61 +R L R AD + ++E LA L T EQG+ + FE+ W R TA L Sbjct: 83 ERERILLRFADLVEQHSEELAQLETLEQGKSIA-------ISRAFEVGCTLNWMRYTAGL 135 Query: 62 E-------LAPEVVFEDETRRDELHRK-PYGVIAAIAPWNWPLMISIWQVIPALYAGNTV 113 L + R RK P GV+A I PWN+PLMI +W+V+PAL AG ++ Sbjct: 136 TTKIAGKTLDLSIPLPQGARYQAWTRKEPVGVVAGIVPWNFPLMIGMWKVMPALAAGCSI 195 Query: 114 VLKPSEYTSVCGLELARVVADA-LPPGVLNTVSGDGSV-GAMLVEDGDVNKIMFTGSGAT 171 V+KPSE T + L +A + ++A +P GV N V+G G+V GA L V KI FTGS AT Sbjct: 196 VIKPSETTPLTMLRVAELASEAGIPDGVFNVVTGSGAVCGAALTSHPHVAKISFTGSTAT 255 Query: 172 GARIVAAAARNLTPTTMELGGNDAAIVLDDADPKAIAPGLFWGAFLNMGQTCACAKRLYV 231 G I AA +LT T+ELGG + AIVL DADP+ + GL G+FLN GQ CA + R+Y+ Sbjct: 256 GKGIARTAADHLTRVTLELGGKNPAIVLKDADPQWVIEGLMTGSFLNQGQVCAASSRIYI 315 Query: 232 PDALHDQIVDELKAIIAALPMGDGLQPGIAMGPVQNPMQLKKVVALVESAREEGGTIVCG 291 L D +V + + +L +G G+ P + P+ + KV + ++ A+ + ++ G Sbjct: 316 EAPLFDTLVSGFEQAVKSLQVGPGMSPVAQINPLVSRAHCDKVCSFLDDAQAQQAELIRG 375 Query: 292 GVLPDGPGNFYPLTLVTGLRDGARLVDEEQFGPVLPIIRYSDLEQAIANANRLDVGLGAS 351 P G G + TLV RL EE FGPV+ ++R +D E+A+ AN + GL AS Sbjct: 376 SNGPAGEGYYVAPTLVVNPDAKLRLTREEVFGPVVNLVRVADGEEALQLANDTEYGLTAS 435 Query: 352 VWSSDSQRAAQVATRLQAGTVWVNQHGMVHPMVPFGGNKRSGWGVEFGQEGLKGVTQPQV 411 VW+ + +A + + RLQAGTVWVN H ++ +PFGG K+SG G +FG + L G + + Sbjct: 436 VWTQNLSQALEYSDRLQAGTVWVNSHTLIDANLPFGGMKQSGTGRDFGPDWLDGWCETKS 495 Query: 412 ISLK 415 + ++ Sbjct: 496 VCVR 499 >FN0454 [C] COG1012 NAD-dependent aldehyde dehydrogenases Fnu Fusobacterium nucleatum Length = 491 Score = 271 bits (692), Expect = 3e-72, Method: Compositional matrix adjust. Identities = 154/419 (36%), Positives = 233/419 (55%), Gaps = 16/419 (3%) Query: 2 QRREYLNRVADAIAANAERLATLVTQEQGRPLGGVGPGQVP--GSRFELW-GCEAWTRAT 58 +R LN++AD I N + LAT+ T + G+P+ +P + F + GC Sbjct: 69 ERARILNKIADIIDENKDLLATVETMDNGKPIRETKLVDIPLAATHFRYFAGCILADEGQ 128 Query: 59 ASLELAPEVVFEDETRRDELHRKPYGVIAAIAPWNWPLMISIWQVIPALYAGNTVVLKPS 118 A++ DE + R+P GV+ I PWN+P +++ W++ PAL AG+TVVLKPS Sbjct: 129 ATVL--------DEKFLSLILREPIGVVGQIIPWNFPFLMAAWKLAPALAAGDTVVLKPS 180 Query: 119 EYTSVCGLELARVVADALPPGVLNTVSGDGSV-GAMLVEDGDVNKIMFTGSGATGARIVA 177 T++ L L ++ D +P GV+N V+G GS G L D++K+ FTGS A G I Sbjct: 181 STTTLSLLVLMELIQDVIPKGVVNLVTGKGSTAGEFLKNHPDLDKLAFTGSTAVGRDIAL 240 Query: 178 AAARNLTPTTMELGGNDAAIVLDDADPKAIAPGLFWGAFLNMGQTCACAKRLYVPDALHD 237 AAA L P T+ELGG A I+LDDAD + G G N GQ C R++V + ++D Sbjct: 241 AAAEKLIPATLELGGKSANIILDDADIEKALEGAQLGILFNQGQVCCAGSRIFVQEGIYD 300 Query: 238 QIVDELKAIIAALPMGDGLQPGIAMGPVQNPMQLKKVVALVESAREEGGTIVCGGV--LP 295 + + +L + +G+ L P MG + Q+K ++ VE A++EGG I+ GGV Sbjct: 301 EFISKLVKKFENIKIGNPLDPTTIMGSQIDARQVKTILDYVEIAKQEGGVILTGGVKYTE 360 Query: 296 DG--PGNFYPLTLVTGLRDGARLVDEEQFGPVLPIIRYSDLEQAIANANRLDVGLGASVW 353 +G GNF TL+T + +G R+ EE FGPV +I++ ++ IA AN + GLG +V+ Sbjct: 361 NGCDKGNFVRPTLITNVNNGCRVSQEEIFGPVAVVIKFKTDDEVIAQANDSEYGLGGAVF 420 Query: 354 SSDSQRAAQVATRLQAGTVWVNQHGMVHPMVPFGGNKRSGWGVEFGQEGLKGVTQPQVI 412 + + RA ++A +Q G VW+N + + PFGG K+SG G E + L+ TQ + I Sbjct: 421 TKNINRALKLAREIQTGRVWINTYNQIPEHAPFGGYKKSGIGRETHKVILEHYTQMKNI 479 >STM1597 [C] COG1012 NAD-dependent aldehyde dehydrogenases Sty Salmonella typhimurium LT2 Length = 481 Score = 255 bits (652), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 155/418 (37%), Positives = 225/418 (53%), Gaps = 10/418 (2%) Query: 3 RREYLNRVADAIAANAERLATLVTQEQGRPLGGVGPGQVPG--SRFELWGCEAWTRATAS 60 R E L ++AD+I NA A L +Q G+PL V ++P F + A R + Sbjct: 70 RAECLLKLADSIEQNALEFARLESQNCGKPLHCVINDEIPAIVDVFRFFAGAA--RCLSG 127 Query: 61 LELAPEVVFEDETRRDELHRKPYGVIAAIAPWNWPLMISIWQVIPALYAGNTVVLKPSEY 120 L + E + R P GV+A+IAPWN+PLM++ W++ PAL AGN VV+KPSE Sbjct: 128 LAAGEYL----EGHTSMIRRDPIGVVASIAPWNYPLMMAAWKLAPALAAGNCVVIKPSEI 183 Query: 121 TSVCGLELARVVADALPPGVLNTVSGDG-SVGAMLVEDGDVNKIMFTGSGATGARIVAAA 179 T + L+LA + D PPGVLN + G G +VG +L V + TGS ATG I+ Sbjct: 184 TPLTALKLAVLAKDIFPPGVLNVLFGRGQTVGDVLTGHEKVRMVSLTGSIATGEHILRHT 243 Query: 180 ARNLTPTTMELGGNDAAIVLDDADPKAIAPGLFWGAFLNMGQTCACAKRLYVPDALHDQI 239 A + T MELGG IV DDAD A+A G+ F N GQ C A R+Y ++D + Sbjct: 244 APAIKRTHMELGGKAPVIVFDDADLDAVAQGVRTFGFYNAGQDCTAACRIYAQRGIYDAL 303 Query: 240 VDELKAIIAALPMGDGLQPGIAMGPVQNPMQLKKVVALVESAREEGGT-IVCGGVLPDGP 298 V++L +++L MG +GP+ + LK+V A VE A+ ++ GG +G Sbjct: 304 VEKLGNAVSSLKMGAPEDESTELGPLSSLAHLKRVTAAVEEAKALSHIRVITGGSQTEGK 363 Query: 299 GNFYPLTLVTGLRDGARLVDEEQFGPVLPIIRYSDLEQAIANANRLDVGLGASVWSSDSQ 358 G ++ TL+ + +V E FGPV+ I + D +Q + AN GL +SVW+ D Sbjct: 364 GYYFAPTLLADAKQEDAIVQREVFGPVVSITVFDDEDQVLRWANDSRYGLASSVWTQDVG 423 Query: 359 RAAQVATRLQAGTVWVNQHGMVHPMVPFGGNKRSGWGVEFGQEGLKGVTQPQVISLKK 416 RA +++ RLQ G W+N H M+ +P GG K+SG+G + GL+ T + I +K Sbjct: 424 RAHRLSARLQYGCTWINTHFMLVSEMPHGGQKQSGYGKDMSLYGLEDYTLVRHIMVKH 481