BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0016.p (420 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value NMB0360 [GEPR] COG0477 Permeases of the major facilitator superf... 437 e-122 NMA2127 [GEPR] COG0477 Permeases of the major facilitator superf... 430 e-120 PM0285 [GEPR] COG0477 Permeases of the major facilitator superfa... 426 e-119 HI0350 [GEPR] COG0477 Permeases of the major facilitator superfa... 361 1e-99 RSc0154 [GEPR] COG0477 Permeases of the major facilitator superf... 298 2e-80 >NMB0360 [GEPR] COG0477 Permeases of the major facilitator superfamily Nme Neisseria meningitidis MC58 Length = 427 Score = 437 bits (1125), Expect = e-122, Method: Compositional matrix adjust. Identities = 229/419 (54%), Positives = 308/419 (73%), Gaps = 12/419 (2%) Query: 10 QYLNRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKTLGLFALVMFPYTWKFVWSP 69 Q +R ML+C+F GFTSGLPL+ L++L+ AWL +++K++GL AL+ P+TWKF+WSP Sbjct: 11 QIFSRNMLVCIFTGFTSGLPLYFLINLIPAWLRSEQVDLKSIGLMALIGLPFTWKFLWSP 70 Query: 70 LMDRFHFGGMGRRRGWMVFTQLLLFLSIGGMGMLDPLTDVSTIAFMASVVAFLSASQDIA 129 LMD +GRRRGWM+ TQ L ++ L+P + IA ++ +VAF SASQDI Sbjct: 71 LMDAVRLPVLGRRRGWMLLTQAGLLAALAVYAFLNPRNHLPLIAGLSVLVAFFSASQDIV 130 Query: 130 IDAYRREILPEAELGLGSAIHVNAYKLSGMVPGALSLVLADQMPWPTVFWITAAFMLPGL 189 +DA+RREIL + ELGLG+++HVNAY+++ ++PG+LSLVLAD+MPW VF IT+ FMLPGL Sbjct: 131 LDAFRREILSDEELGLGNSVHVNAYRIAALIPGSLSLVLADRMPWLEVFVITSLFMLPGL 190 Query: 190 LCSL-LVKEPKVYGTPPKSLTEAVVLPFREFIARGGWGNALWVLGFIFLYKLGDSMATAL 248 L +L L +EP + PK+L + VV PF+EF R G +A+ VL FIFLYKLGDSMATAL Sbjct: 191 LMTLFLAREPVLPPAVPKTLKQTVVEPFKEFFTRKGIASAVCVLLFIFLYKLGDSMATAL 250 Query: 249 ATKFYIDLGFSMTEIGVVSKTTSLWASVAGGIIGGIWMVRLGINRGLWVFGVLQAVPILG 308 AT FY+D+GFS T+IG+++K LW +VA GI+GG+WM+++G+N+ LW+FG +QAV +LG Sbjct: 251 ATPFYLDMGFSKTDIGLIAKNAGLWPAVAAGILGGVWMLKIGVNKALWLFGAVQAVTVLG 310 Query: 309 FAWLAHVG-------ANLPVLAVVIGLEAFGVGLGTTAFVAYIMRETDPRYTATQFALFT 361 F WLA G +LA VIG EA GVGLGT AFV+Y+ RET+P +TATQ ALFT Sbjct: 311 FVWLAGFGPFDTVGTGERLMLAAVIGAEAVGVGLGTAAFVSYMARETNPAFTATQLALFT 370 Query: 362 SLMAVPRTFVNSSVGYIVADTGWLNFFLICFVLALPGMLMLPRIAPWNEKPVESQTQKA 420 SL AVPRT +NS GY++ G++ FF +CF LALPGML+L ++APWN + +TQ A Sbjct: 371 SLSAVPRTVINSFAGYLIEWLGYVPFFQLCFALALPGMLLLLKVAPWNGE----KTQDA 425 >NMA2127 [GEPR] COG0477 Permeases of the major facilitator superfamily NmA Neisseria meningitidis Z2491 Length = 427 Score = 430 bits (1105), Expect = e-120, Method: Compositional matrix adjust. Identities = 230/419 (54%), Positives = 309/419 (73%), Gaps = 12/419 (2%) Query: 10 QYLNRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKTLGLFALVMFPYTWKFVWSP 69 Q +R ML+C+F GFTSGLPL+ L++L+ AWL +++K++GL AL+ P+TWKF+WSP Sbjct: 11 QIFSRNMLVCIFTGFTSGLPLYFLINLIPAWLRSEQVDLKSIGLMALIGLPFTWKFLWSP 70 Query: 70 LMDRFHFGGMGRRRGWMVFTQLLLFLSIGGMGMLDPLTDVSTIAFMASVVAFLSASQDIA 129 LMD +GRRRGWM+ TQ L ++ L+P + IA ++ +VAF SASQDI Sbjct: 71 LMDAVRLPVLGRRRGWMLLTQAGLLAALAAYAFLNPRNHLPLIAGLSVLVAFFSASQDIV 130 Query: 130 IDAYRREILPEAELGLGSAIHVNAYKLSGMVPGALSLVLADQMPWPTVFWITAAFMLPGL 189 +DA+RREIL + ELGLG+++HVNAY+++ ++PG+LSLVLAD+MPW VF IT+ FMLPGL Sbjct: 131 LDAFRREILSDEELGLGNSVHVNAYRVAALIPGSLSLVLADRMPWSEVFVITSLFMLPGL 190 Query: 190 LCSL-LVKEPKVYGTPPKSLTEAVVLPFREFIARGGWGNALWVLGFIFLYKLGDSMATAL 248 L +L L +EP + PK+L + VV PF+EF R G +A+ VL FIFLYKLGDSMATAL Sbjct: 191 LMTLFLAREPVLPPAVPKTLKQTVVEPFKEFFTRKGIASAVCVLLFIFLYKLGDSMATAL 250 Query: 249 ATKFYIDLGFSMTEIGVVSKTTSLWASVAGGIIGGIWMVRLGINRGLWVFGVLQAVPILG 308 AT FY+D+GFS T+IG+++K LW +VA GI+GG+WM+++G+N+ LW+FG +QAV +LG Sbjct: 251 ATPFYLDMGFSKTDIGLIAKNAGLWPAVAAGILGGVWMLKIGVNKALWLFGAVQAVTVLG 310 Query: 309 FAWLAHVG-------ANLPVLAVVIGLEAFGVGLGTTAFVAYIMRETDPRYTATQFALFT 361 F WLA G +LA VIG EA GVGLGT AFV+Y+ RET+P +TATQ ALFT Sbjct: 311 FVWLAGFGHFDTVGTGERLMLAAVIGAEAVGVGLGTAAFVSYMARETNPAFTATQLALFT 370 Query: 362 SLMAVPRTFVNSSVGYIVADTGWLNFFLICFVLALPGMLMLPRIAPWNEKPVESQTQKA 420 SL AVPRT +NS GY++ G++ FF +CFVLALPGML+L ++APWN + +TQ A Sbjct: 371 SLSAVPRTVINSFAGYLIEWLGYVPFFQLCFVLALPGMLLLLKVAPWNGE----KTQDA 425 >PM0285 [GEPR] COG0477 Permeases of the major facilitator superfamily Pmu Pasteurella multocida Length = 425 Score = 426 bits (1095), Expect = e-119, Method: Compositional matrix adjust. Identities = 216/411 (52%), Positives = 290/411 (70%), Gaps = 11/411 (2%) Query: 10 QYLNRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKTLGLFALVMFPYTWKFVWSP 69 Q +R ML+C+F GF+SGLPL++L ++ AWL+ S ++VKT+G F L+ FPYTWKF+ SP Sbjct: 11 QIFSRNMLLCIFTGFSSGLPLYVLFQMVPAWLSSSNVDVKTIGFFTLIGFPYTWKFIISP 70 Query: 70 LMDRFHFGGMGRRRGWMVFTQLLLFLSIGGMGMLDPLTDVSTIAFMASVVAFLSASQDIA 129 L+DR++ +GRRR WM TQ+ L + +G DP+ +++ +A +++ +A SA QDI Sbjct: 71 LLDRYYPNFLGRRRSWMFMTQVALLALLALLGQYDPVANITIVAVISTSIAVFSAVQDIV 130 Query: 130 IDAYRREILPEAELGLGSAIHVNAYKLSGMVPGALSLVLADQMPWPTVFWITAAFMLPGL 189 IDAYRREIL + ELGLG++IHVNAY++SG++PG LSL+LAD +PW VF TA FM+PGL Sbjct: 131 IDAYRREILTDEELGLGNSIHVNAYRISGLIPGGLSLILADSLPWDVVFIFTALFMIPGL 190 Query: 190 LCSL-LVKEPKVYGTPPKSL--TEAVVLPFREFIARGGWGNALWVLGFIFLYKLGDSMAT 246 + SL L KEP V +SL LPF+EF +R G +AL ++ FIFLYK GDS+AT Sbjct: 191 ILSLFLSKEPDV-PQIDRSLPFYHTFALPFKEFFSRKGVASALGLIFFIFLYKFGDSLAT 249 Query: 247 ALATKFYIDLGFSMTEIGVVSKTTSLWASVAGGIIGGIWMVRLGINRGLWVFGVLQAVPI 306 +L TKF +D+GFS T+IG V K SLWAS+ G++GGI M+R+GINR LW+FG +Q + I Sbjct: 250 SLQTKFILDMGFSKTDIGTVVKLNSLWASIISGMLGGILMLRIGINRSLWLFGFVQLITI 309 Query: 307 LGFAWLAHVGA-------NLPVLAVVIGLEAFGVGLGTTAFVAYIMRETDPRYTATQFAL 359 LGF W+A G VL VI E GVGLGT AFVA++ RET+P YTATQ A+ Sbjct: 310 LGFVWMASYGKFNTIGSFEFFVLTTVIIGEYIGVGLGTAAFVAFMARETNPLYTATQLAI 369 Query: 360 FTSLMAVPRTFVNSSVGYIVADTGWLNFFLICFVLALPGMLMLPRIAPWNE 410 FTSL A+P ++ G +VAD G+ FF ICF A+PGMLML ++APW+ Sbjct: 370 FTSLSAIPSKIFSAFSGVLVADYGYYTFFWICFFAAIPGMLMLFKVAPWHS 420 >HI0350 [GEPR] COG0477 Permeases of the major facilitator superfamily Hin Haemophilus influenzae Length = 425 Score = 361 bits (927), Expect = 1e-99, Method: Compositional matrix adjust. Identities = 199/417 (47%), Positives = 272/417 (65%), Gaps = 9/417 (2%) Query: 10 QYLNRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKTLGLFALVMFPYTWKFVWSP 69 Q R+MLIC F GF SGLPLF+L +L WL L+++ +G VM PY KF+W+P Sbjct: 8 QIFTRKMLICAFTGFNSGLPLFVLSQMLPVWLTDKHLSIELIGAVTGVMLPYGLKFLWAP 67 Query: 70 LMDRFHFGGMGRRRGWMVFTQLLLFLSIGGMGMLDPLTDVSTIAFMASVVAFLSASQDIA 129 L+DR+ +GRRR WM+ +Q+ L + + + + DPLT + T+A +A ++AF SA+QDI Sbjct: 68 LLDRYFPSFLGRRRSWMLLSQVALLILLYIISLFDPLTQLGTVANIALLIAFFSATQDIV 127 Query: 130 IDAYRREILPEAELGLGSAIHVNAYKLSGMVPGALSLVLADQMPWPTVFWITAAFMLPGL 189 +DAYRREIL + ELGLG+ IH+NAY+++G++PG LSL LA PW TVF TA ML G+ Sbjct: 128 LDAYRREILSDHELGLGNTIHINAYRIAGLIPGGLSLYLAAIYPWETVFLWTALCMLAGI 187 Query: 190 LCSL-LVKEPKV-YGTPPKSLTEAVVLPFREFIARGGWGNALWVLGFIFLYKLGDSMATA 247 +L L KEPK+ + +A +P +EF R G A+ L F+FLYK GDS AT Sbjct: 188 FMTLFLAKEPKIDMQQTNQPFYQAFWIPLQEFFQRKGVIQAIGFLLFLFLYKFGDSFATT 247 Query: 248 LATKFYIDLGFSMTEIGVVSKTTSLWASVAGGIIGGIWMVRLGINRGLWVFGVLQAVPIL 307 L TKF D+GFS +I +V K+T+LW+S+ G+ GG+ M++LGINR LW+FG++Q V I Sbjct: 248 LQTKFIYDMGFSKEDIAIVVKSTALWSSILSGLAGGMIMLKLGINRALWLFGLVQMVTIG 307 Query: 308 GFAWLAHVG-------ANLPVLAVVIGLEAFGVGLGTTAFVAYIMRETDPRYTATQFALF 360 GF WLA G A L L VVI E GVGLGT AFVA++ RE++P YTATQ ALF Sbjct: 308 GFIWLAAFGHFDVITSAELWKLGVVIAAEYIGVGLGTAAFVAFMARESNPLYTATQLALF 367 Query: 361 TSLMAVPRTFVNSSVGYIVADTGWLNFFLICFVLALPGMLMLPRIAPWNEKPVESQT 417 TSL A+P + GY+V G+ +F C LA+PGML L +AP ++ ++ + Sbjct: 368 TSLSALPSKVLGILSGYVVGAVGYYQYFWFCLFLAIPGMLCLFWVAPLKQENNKTSS 424 >RSc0154 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 426 Score = 298 bits (763), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 179/403 (44%), Positives = 254/403 (63%), Gaps = 11/403 (2%) Query: 7 SWHQYL----NRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKTLGLFALVMFPYT 62 ++H YL NRR+ + LGF SGLPL + LQAW+ GL+++T+GLF+LV Y Sbjct: 2 TFHDYLDVFRNRRIGAMLLLGFASGLPLALTSGTLQAWMTVEGLDIRTIGLFSLVGQAYI 61 Query: 63 WKFVWSPLMDRFHFGGMGRRRGWMVFTQLLLFLSIGGMGMLDPLTDVSTIAFMASVVAFL 122 +KF+W+PLMDRF +GRRRGW+V TQ L SI M P + +A +A +VAFL Sbjct: 62 FKFLWAPLMDRFTPPLIGRRRGWLVLTQAGLAASIAAMAFCPPHAALWALAGLAVLVAFL 121 Query: 123 SASQDIAIDAYRREILPEAELGLGSAIHVNAYKLSGMVPGALSLVLADQ-MPWPTVFWIT 181 SASQDI DAY ++L +E G+G+A+ V Y+L+ +V G L+L LAD+ M W +++ + Sbjct: 122 SASQDIVFDAYSTDVLHASERGVGAAVKVLGYRLAMLVSGGLALWLADRVMGWSSMYLLM 181 Query: 182 AAFMLPGLLCSLLVKEPKVYGTPPKSLTEAVVLPFREFIA-RGGWGNALWVLGFIFLYKL 240 A M +L +L EP+ PP+SL EAVV P R+F A RG W +L I LYKL Sbjct: 182 AGLMALFVLATLWSPEPEAAARPPRSLQEAVVGPLRDFFARRGAWA----LLALIVLYKL 237 Query: 241 GDSMATALATKFYID-LGFSMTEIGVVSKTTSLWASVAGGIIGGIWMVRLGINRGLWVFG 299 GD+ A +L+T F I +GFS E+G+V+KT L A++ G + GG MVRLG+ R L +FG Sbjct: 238 GDAFAGSLSTTFLIRGVGFSAGEVGIVNKTLGLVATIIGALYGGTLMVRLGLVRALLLFG 297 Query: 300 VLQAVPILGFAWLAHVGANLPVLAVVIGLEAFGVGLGTTAFVAYIMRETDPRYTATQFAL 359 VLQAV LG+ LA +L +A+ IG+E G+GT AFVA +M + ++ATQ+AL Sbjct: 298 VLQAVSNLGYWVLAVTPQHLWTMALAIGIENLCGGMGTAAFVALLMALCNRSFSATQYAL 357 Query: 360 FTSLMAVPRTFVNSSVGYIVADTGWLNFFLICFVLALPGMLML 402 ++L ++ R +V + GY+V GW F+L+ A PG+ +L Sbjct: 358 LSALASIGRVYVGPTSGYLVEAYGWPAFYLMTVAFAFPGLALL 400