BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0011.0158.p         (161 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

RSc2628 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosph...   154   9e-38
VC0593 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophospho...   115   3e-26
NMB0745 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosph...   113   2e-25
NMA0958 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosph...   112   4e-25
SPy1100 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosph...   110   1e-24

>RSc2628 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Rso
           Ralstonia solanacearum
          Length = 169

 Score =  154 bits (389), Expect = 9e-38,   Method: Compositional matrix adjust.
 Identities = 84/156 (53%), Positives = 106/156 (67%)

Query: 6   TLAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGDDYVNAVALVS 65
           T+A+IGIG NLGDAR  V+ A+  LA      +   SSLYR+APVDA+GDDY+NAV  + 
Sbjct: 2   TVAYIGIGANLGDARQAVKDAVVCLAQQVGISITGKSSLYRSAPVDATGDDYINAVVRID 61

Query: 66  TTLPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPRMAQRA 125
           T   A  LL     IE Q GRERP+RNAPRTLDLD+L+YG+  +   ELTVPHPR+ QRA
Sbjct: 62  THFTAGQLLRICHHIEDQFGRERPFRNAPRTLDLDLLLYGDQTLTSPELTVPHPRVGQRA 121

Query: 126 FVLAPLLEIDENAVIPGVGAARPLMDAITDQPIRRI 161
           F L PL E+  + VIPG+GA   L+  + DQ I ++
Sbjct: 122 FTLLPLHELAPDLVIPGIGAVAALLPGVADQVIEKM 157


>VC0593 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Vch
           Vibrio cholerae
          Length = 167

 Score =  115 bits (289), Expect = 3e-26,   Method: Compositional matrix adjust.
 Identities = 65/137 (47%), Positives = 85/137 (62%), Gaps = 2/137 (1%)

Query: 7   LAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGD-DYVNAVALVS 65
           LA+I IG NLGD  A  + AI +L  LP+++L+ +SSLY + P+      DY+NAVA + 
Sbjct: 3   LAYIAIGSNLGDPVAQAQLAIQQLTLLPKSRLIAASSLYSSTPMGPQNQPDYINAVAAIE 62

Query: 66  TTLPALDLLHALQAIELQHGRERPY-RNAPRTLDLDVLMYGEARIADQELTVPHPRMAQR 124
           T L  L+LL   Q IEL+ GR R   R  PRTLDLD+++YG   I  + LT+PH  M  R
Sbjct: 63  TELTPLELLDCTQRIELEQGRVRKSERWGPRTLDLDIVLYGNEVIETERLTIPHYGMKVR 122

Query: 125 AFVLAPLLEIDENAVIP 141
            FVL PL EI  N  +P
Sbjct: 123 EFVLYPLAEIAPNLTLP 139


>NMB0745 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Nme
           Neisseria meningitidis MC58
          Length = 164

 Score =  113 bits (282), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 67/154 (43%), Positives = 89/154 (57%), Gaps = 1/154 (0%)

Query: 7   LAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGD-DYVNAVALVS 65
            A I +G NL +    V  A+  L++ P  +L ++SSLY TAPV      D+VNAV  VS
Sbjct: 6   FAVIALGSNLENPAQQVRAALDTLSSHPDIRLKQASSLYMTAPVGYDNQPDFVNAVCTVS 65

Query: 66  TTLPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPRMAQRA 125
           TTL  + LL  L  IE   GRER +RNAPRTLDLD++ +      D  LT+PHPR  +R+
Sbjct: 66  TTLDGIALLAELNRIEADFGRERSFRNAPRTLDLDIIDFDGISSDDTRLTLPHPRAHERS 125

Query: 126 FVLAPLLEIDENAVIPGVGAARPLMDAITDQPIR 159
           FV+ PL EI  + V+   G    L   + +Q IR
Sbjct: 126 FVIRPLAEILPDFVLGKHGKVAELSKRLGNQGIR 159


>NMA0958 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase NmA
           Neisseria meningitidis Z2491
          Length = 164

 Score =  112 bits (280), Expect = 4e-25,   Method: Compositional matrix adjust.
 Identities = 66/154 (42%), Positives = 89/154 (57%), Gaps = 1/154 (0%)

Query: 7   LAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGD-DYVNAVALVS 65
            A I +G NL +    V  A+  L++ P  +L ++SSLY TAPV      D+VNAV  VS
Sbjct: 6   FAVIALGSNLENPAQQVRAALDTLSSHPDIRLKQASSLYMTAPVGYDNQPDFVNAVCTVS 65

Query: 66  TTLPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPRMAQRA 125
           TTL  + LL  L  IE   GRER +RNAPRTLDLD++ +      D  LT+PHPR  +R+
Sbjct: 66  TTLDGIALLAELNRIEADFGRERSFRNAPRTLDLDIIDFDGISSDDPRLTLPHPRAHERS 125

Query: 126 FVLAPLLEIDENAVIPGVGAARPLMDAITDQPIR 159
           FV+ PL EI  + ++   G    L   + +Q IR
Sbjct: 126 FVIRPLAEILPDFILGKHGKVAELSKRLGNQGIR 159


>SPy1100 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Spy
           Streptococcus pyogenes M1 GAS
          Length = 166

 Score =  110 bits (276), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 58/137 (42%), Positives = 83/137 (60%), Gaps = 1/137 (0%)

Query: 6   TLAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGD-DYVNAVALV 64
           T+ ++ +G N+GD  A ++ A+  LA LPQT+LL  SS+Y T     +G  D++N    +
Sbjct: 2   TIVYLSLGTNMGDRAAYLQKALEALADLPQTRLLAQSSIYETTAWGKTGQADFLNMACQL 61

Query: 65  STTLPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPRMAQR 124
            T L A D L   QAIE   GR R  +   RT+D+D+L++GE     +EL VPHP M +R
Sbjct: 62  DTQLTAADFLKETQAIEQSLGRVRHEKWGSRTIDIDILLFGEEVYDTKELKVPHPYMTER 121

Query: 125 AFVLAPLLEIDENAVIP 141
           AFVL PLLE+  +  +P
Sbjct: 122 AFVLIPLLELQPDLKLP 138