BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0011.0088.p (369 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA1352 [GEPR] COG0477 Permeases of the major facilitator superfa... 271 2e-72 SMa1959 [GEPR] COG0477 Permeases of the major facilitator superf... 253 5e-67 YPO3263 [GEPR] COG0477 Permeases of the major facilitator superf... 236 6e-62 CAC0560 [GEPR] COG0477 Permeases of the major facilitator superf... 226 1e-58 CAC3482 [GEPR] COG0477 Permeases of the major facilitator superf... 220 3e-57 >PA1352 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 403 Score = 271 bits (693), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 216/362 (59%), Positives = 263/362 (72%) Query: 1 VANVYYAQPLLDALSDDFKINQAAVGGVVTATQLGCALALLLLVPLGDKVPRKKLMGIQL 60 VANVYYAQPLLD L +F I QA VG + TQ GCALALLL+VPLGD + R++LM +QL Sbjct: 24 VANVYYAQPLLDVLGAEFAIGQAGVGLLFGTTQAGCALALLLVVPLGDLLERRRLMFVQL 83 Query: 61 LALVCALVTVGLARSSYVLLAGMLAVGLLGTAMTQGLIAYAASAAGEEERGRVVGAAQSG 120 L LV +L+ VG A + L G+L +GLLGTAMTQGL+AYAA+ A ERGRVVGAAQ G Sbjct: 84 LLLVLSLLLVGFAGDTLGLALGLLGLGLLGTAMTQGLLAYAAALAAPGERGRVVGAAQGG 143 Query: 121 VFIGLLLSRVFSGAVSDVTGWRGVYLCAAIMMLCLAWPLWKRLPAIPVQADGLRYLTLIK 180 V IGLLL+R +G ++D+ GWR VYL +A M L LW+ LPA P GL Y L+ Sbjct: 144 VVIGLLLARSLAGLLADLGGWRSVYLVSAASMGGLGLLLWRVLPAAPSNELGLTYRQLLG 203 Query: 181 SMWCLLRDDKVLQVRGVLAMLMFAAFNVFWSALVLPLSASPYHFSHTVIGAFGLVGVIGA 240 SM+ LL +VLQVRG+L +LMFAAF VFWS+LVL L A P+ SH+ IGAFGLVG +GA Sbjct: 204 SMFDLLASQRVLQVRGLLGLLMFAAFGVFWSSLVLLLGAPPHSLSHSAIGAFGLVGALGA 263 Query: 241 LAASKAGRWSDQGHAQRTSAVSLAVLLLAWWPLSLMESSLWALVAGIILLDLGGQALHVT 300 L A++AG +D+GHAQ S +L +LLL+W PL+L SL AL+ G++LLDL GQA+HV Sbjct: 264 LGAARAGSLADRGHAQALSGGALLLLLLSWLPLALGAHSLAALILGVLLLDLAGQAIHVL 323 Query: 301 NQSLIFRSSPQAHSRLVGVYMLFYAVGSGLGAISTTAIYAARGWQGVCFLGAAVSFIALL 360 NQSL+F P+AHSRLVG YMLFYA GSGLGA + TA+YA GW V LGAA+S AL Sbjct: 324 NQSLVFAIDPRAHSRLVGCYMLFYAAGSGLGASAGTAMYAWAGWDAVSLLGAAISLAALA 383 Query: 361 FW 362 FW Sbjct: 384 FW 385 >SMa1959 [GEPR] COG0477 Permeases of the major facilitator superfamily Sme Sinorhizobium meliloti Length = 469 Score = 253 bits (646), Expect = 5e-67, Method: Compositional matrix adjust. Identities = 174/362 (48%), Positives = 232/362 (64%), Gaps = 1/362 (0%) Query: 1 VANVYYAQPLLDALSDDFKINQAAVGGVVTATQLGCALALLLLVPLGDKVPRKKLMGIQL 60 VAN Y+A PLLD ++DD + +A +G VV ATQLG L L+LLVP+GD V R+ L+ IQ Sbjct: 100 VANAYFAHPLLDVIADDLSLPRATIGFVVGATQLGYGLGLVLLVPVGDLVDRRNLVIIQS 159 Query: 61 LALVCALVTVGLARSSYVLLAGMLAVGLLGTAMTQGLIAYAASAAGEEERGRVVGAAQSG 120 L V AL+ VG A + VL ++A+G A TQ +AYAAS A EERG VVG SG Sbjct: 160 LLSVLALLCVGFAPTEEVLFPALIAMGFFAVA-TQAFVAYAASLARPEERGAVVGTVTSG 218 Query: 121 VFIGLLLSRVFSGAVSDVTGWRGVYLCAAIMMLCLAWPLWKRLPAIPVQADGLRYLTLIK 180 + +G+LL+R +GAV D+ GWR VYL +A L + L + +PA P + Y LI Sbjct: 219 IVLGILLARTVAGAVVDIAGWRAVYLLSAAFTLAITAILARVVPAQPKSGPAVSYPKLIG 278 Query: 181 SMWCLLRDDKVLQVRGVLAMLMFAAFNVFWSALVLPLSASPYHFSHTVIGAFGLVGVIGA 240 S++ L + VL+VR +LA L+FA + LVLPLSA PY SH IG FGL G GA Sbjct: 279 SLFTLFLQEPVLRVRAILAFLIFADVTTLLTPLVLPLSAPPYSLSHAAIGLFGLAGAAGA 338 Query: 241 LAASKAGRWSDQGHAQRTSAVSLAVLLLAWWPLSLMESSLWALVAGIILLDLGGQALHVT 300 L AS+AGRW+D+G QR + V+L ++L +W + L+ S+ LV G++LLD G QA+HV Sbjct: 339 LGASRAGRWTDEGFGQRVTGVALTLMLCSWILIGLLPYSILFLVTGVLLLDFGLQAVHVA 398 Query: 301 NQSLIFRSSPQAHSRLVGVYMLFYAVGSGLGAISTTAIYAARGWQGVCFLGAAVSFIALL 360 +Q LI+R P+A SRL YM+FY+ GS LG+ +T +YA W GV LGA ++ ALL Sbjct: 399 SQGLIYRVRPEAQSRLTAAYMVFYSTGSALGSSISTLVYARWAWTGVSMLGAGIAAAALL 458 Query: 361 FW 362 FW Sbjct: 459 FW 460 >YPO3263 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 399 Score = 236 bits (602), Expect = 6e-62, Method: Compositional matrix adjust. Identities = 149/370 (40%), Positives = 232/370 (62%), Gaps = 4/370 (1%) Query: 1 VANVYYAQPLLDALSDDFKINQAAVGGVVTATQLGCALALLLLVPLGDKVPRKKLM-GIQ 59 VA+ YYAQPLL+ ++ +F ++ G +VTA QLG A+ L+ LVPLGD R+ L+ G+ Sbjct: 25 VASNYYAQPLLETIATNFNLSVNQAGFIVTAAQLGYAVGLMFLVPLGDMFERRGLIVGMT 84 Query: 60 LLALVCALVTVGLARSSYVLLAGMLAVGLLGTAMTQGLIAYAASAAGEEERGRVVGAAQS 119 LLA L+T ++++ +++ G GL + + Q L+ AA+ A E+RG+VVG S Sbjct: 85 LLAAGGMLIT-AMSQNLTMMIIGTALTGLF-SVVAQLLVPLAATLAAPEKRGKVVGIIMS 142 Query: 120 GVFIGLLLSRVFSGAVSDVTGWRGVYLCAAIMMLCLAWPLWKRLPAIPVQADGLRYLTLI 179 G+ +G+LL+R +GA++ + GWR +Y A+ +M +A LW+ LP Q GL Y L+ Sbjct: 143 GLLLGILLARTVAGALATLGGWRTIYWVASALMFIMALVLWRCLPRYK-QHTGLNYGQLL 201 Query: 180 KSMWCLLRDDKVLQVRGVLAMLMFAAFNVFWSALVLPLSASPYHFSHTVIGAFGLVGVIG 239 S++ L VL+ R +L L FA F+V W+++ L+A P+ +S IG FGLVG G Sbjct: 202 GSIFALFIHTPVLRTRALLGALSFANFSVLWTSMAFLLAAPPFGYSEATIGLFGLVGAAG 261 Query: 240 ALAASKAGRWSDQGHAQRTSAVSLAVLLLAWWPLSLMESSLWALVAGIILLDLGGQALHV 299 AL A+KAG+ +D+G A+ T++ L +LLL+W P++ + S+ AL+ GII+LDL QA+HV Sbjct: 262 ALMATKAGQLADKGKARVTTSAGLVLLLLSWLPIAFGQHSIIALIIGIIVLDLAVQAVHV 321 Query: 300 TNQSLIFRSSPQAHSRLVGVYMLFYAVGSGLGAISTTAIYAARGWQGVCFLGAAVSFIAL 359 TNQS+++R P+A +RL YM Y +G LG++ + A Y GW GV G + + + Sbjct: 322 TNQSVMYRMMPEARNRLTAGYMTSYFIGGALGSLISAAAYQHAGWYGVSTAGLVLCLLNI 381 Query: 360 LFWLMAGRGE 369 + WL+ R + Sbjct: 382 VTWLVGKRSD 391 >CAC0560 [GEPR] COG0477 Permeases of the major facilitator superfamily Cac Clostridium acetobutylicum Length = 441 Score = 226 bits (575), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 139/361 (38%), Positives = 207/361 (57%), Gaps = 2/361 (0%) Query: 1 VANVYYAQPLLDALSDDFKINQAAVGGVVTATQLGCALALLLLVPLGDKVPRKKLMGIQL 60 VAN+YY QPLL ++ F + +A G VVT TQ+G AL +L LVPLGD RKKL+ L Sbjct: 64 VANLYYCQPLLGQIAKSFNVTEANAGFVVTLTQVGYALGMLFLVPLGDIKERKKLIIEML 123 Query: 61 LALVCALVTVGLARSSYVLLAGMLAVGLLGTAMTQGLIAYAASAAGEEERGRVVGAAQSG 120 L + L ++R+ YVLL +G T + Q ++ +AA + EERG+V+G SG Sbjct: 124 LLVSVFLFAAFISRNYYVLLVTSFLIG-FTTIVPQLIVPFAAHLSKPEERGQVIGNVLSG 182 Query: 121 VFIGLLLSRVFSGAVSDVTGWRGVYLCAAIMMLCLAWPLWKRLPAIPVQADGLRYLTLIK 180 + IG+LLSRVFSG + D+ GWR VYL A+++M+ + + P + Y LI Sbjct: 183 LLIGILLSRVFSGIIGDILGWRNVYLIASLLMVSFLFIIVFLFPK-SKPTSKISYKKLIF 241 Query: 181 SMWCLLRDDKVLQVRGVLAMLMFAAFNVFWSALVLPLSASPYHFSHTVIGAFGLVGVIGA 240 SMW L++ +KVL+ + LMF +F++FW+ALV L + Y+ G FGLVG++GA Sbjct: 242 SMWGLIKREKVLREASINGALMFGSFSIFWTALVFLLESKVYNMGSKEAGFFGLVGIVGA 301 Query: 241 LAASKAGRWSDQGHAQRTSAVSLAVLLLAWWPLSLMESSLWALVAGIILLDLGGQALHVT 300 LAA G+ +D+ + ++ +A+ M ++ LV G+ILLDLG Q V+ Sbjct: 302 LAAPVVGKVADKKTPRFAVGFAIIFSTIAYVCFWGMGYKIYGLVIGVILLDLGNQTGQVS 361 Query: 301 NQSLIFRSSPQAHSRLVGVYMLFYAVGSGLGAISTTAIYAARGWQGVCFLGAAVSFIALL 360 NQ+ + S Q SR+ V+M+ Y +G +G+ + GW GVC +G IA++ Sbjct: 362 NQARVQAISDQERSRINTVFMVSYFIGGSIGSFVAAVFWQKFGWSGVCAIGMFFQIIAVI 421 Query: 361 F 361 F Sbjct: 422 F 422 >CAC3482 [GEPR] COG0477 Permeases of the major facilitator superfamily Cac Clostridium acetobutylicum Length = 394 Score = 220 bits (561), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 125/360 (34%), Positives = 210/360 (58%), Gaps = 2/360 (0%) Query: 1 VANVYYAQPLLDALSDDFKINQAAVGGVVTATQLGCALALLLLVPLGDKVPRKKLMGIQL 60 VAN+YY QPLL +S F +++ +VG TQ+G A+ ++L++PLGD R+ L+ L Sbjct: 31 VANLYYIQPLLADISKTFNVSEISVGSAAMLTQIGYAVGMVLILPLGDIKERRNLITTIL 90 Query: 61 LALVCALVTVGLARSSYVLLAGMLAVGLLGTAMTQGLIAYAASAAGEEERGRVVGAAQSG 120 L V +L ++ + + Y+L AVG + + Q +I AA + +++RGR++G SG Sbjct: 91 LFSVISLASMFFSSNIYILTISSFAVGF-TSIIPQLIIPLAAQLSNQKDRGRIIGTVMSG 149 Query: 121 VFIGLLLSRVFSGAVSDVTGWRGVYLCAAIMMLCLAWPLWKRLPAIPVQADGLRYLTLIK 180 + IG+L+SR FSG + GWR VY+ AAIMM+ L L K LP + + ++Y+ L+K Sbjct: 150 LLIGILVSRTFSGILGAYWGWRVVYIIAAIMMIFLMIALRKLLP-VSKPSSNVKYIELLK 208 Query: 181 SMWCLLRDDKVLQVRGVLAMLMFAAFNVFWSALVLPLSASPYHFSHTVIGAFGLVGVIGA 240 SM+ L++ + VL+ + +MFAAF+ FW++L L + Y+ G FGLVGV GA Sbjct: 209 SMFQLIKSEPVLREASINGAMMFAAFSAFWTSLTFLLQSPHYNMGSQAAGLFGLVGVSGA 268 Query: 241 LAASKAGRWSDQGHAQRTSAVSLAVLLLAWWPLSLMESSLWALVAGIILLDLGGQALHVT 300 LAA GR +D+ + + + ++ +++ L+ ++ L+ G++LLDLG Q+ +V+ Sbjct: 269 LAAPLVGRIADKKGPRFIIGICIPIITISYLLFLLLGFKIFGLILGVMLLDLGVQSGNVS 328 Query: 301 NQSLIFRSSPQAHSRLVGVYMLFYAVGSGLGAISTTAIYAARGWQGVCFLGAAVSFIALL 360 NQ+ + + + +R+ VYM+ + +G G+ + Y GW GVC G + I + Sbjct: 329 NQTRVHSLNEKMRNRINTVYMVSFFLGGAFGSFMGSFTYVHFGWYGVCIFGISTQIITFI 388