BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0011.0061.p (450 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp1572 [GEPR] COG0477 Permeases of the major facilitator superf... 343 6e-94 YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 341 2e-93 RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 337 3e-92 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 315 2e-85 RSp0182 [GEPR] COG0477 Permeases of the major facilitator superf... 302 1e-81 >RSp1572 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 433 Score = 343 bits (879), Expect = 6e-94, Method: Compositional matrix adjust. Identities = 183/410 (44%), Positives = 252/410 (61%), Gaps = 10/410 (2%) Query: 12 SATPSLASQAE--DAIYRKVWLRIIPFLFICYVVSFLDRINIGFAQLQMKQDLGFSDAMY 69 +A P+ A E ++Y V RI+PFL CY+ ++LDRINIGFA+LQM+ DL SDA Y Sbjct: 4 NAIPAQAHSGERSTSVYSVVNRRILPFLATCYLFAYLDRINIGFAKLQMQNDLALSDAAY 63 Query: 70 GLGAAIFYVGYVLFEVPSNMALARFGARRTFSRIMVLWGLASVGMMAVTDAAHFYTLRFL 129 GLGA IF+ GY+LFEVPSN+ L + GARRT SRI++LWG+ S M+ VTD FY LRFL Sbjct: 64 GLGAGIFFFGYMLFEVPSNLLLVKIGARRTLSRILILWGIVSASMLFVTDVWTFYALRFL 123 Query: 130 LGVFEAGFFPGIVLYLSYWFLARRRAAVMAIFFAGVAVAGVLGGLVSGWIMRDMAGVMGL 189 LGVFEAGF PG++ YL+ W+ R A MA+ + GV+GG S WIM AG GL Sbjct: 124 LGVFEAGFAPGMIYYLTQWYPGERMARAMAVVLGAAPLGGVIGGPASTWIMGHFAGAGGL 183 Query: 190 YGWQWMFAIEGAPAVLLGLLAIFLLADGPAQAKWLSPEERSFLQARHQQEALRTHHVSGH 249 GWQWMF EG P++LLG+ A L D PA A+WL+ +++ + + A G Sbjct: 184 AGWQWMFLAEGIPSILLGIAAYGYLVDKPADARWLTDAQKAVIAGDIARAA------PGQ 237 Query: 250 SLAALRQALSHRTTYLFAFIYFALTCGSLTLNFWMPLMIRDFGIKDVVEVSLYSVIPNAI 309 + ++ +AL+ Y+ A YF L CG + FW+P +++ G+ D+ ++ LYS IPN Sbjct: 238 A-SSFGKALTEPKLYVLAAAYFCLICGVYAVGFWLPSILKSAGLSDLFQIGLYSAIPNLA 296 Query: 310 GAVGLILIARRSDRRNERHGHFAVCTTGGALALAALTLHPSSFAVSLGLLSVAAVLIFAA 369 V + + RRSDRR ERH H A+ GA L A + +SF +L +++A+ IFA+ Sbjct: 297 MIVAMYALGRRSDRRGERHLHSAITAVLGA-GLLAWAAYATSFPAALISITLASAAIFAS 355 Query: 370 LPIFWSLPPGLLPAQTIAPGIAFISSVGITSGIVSPWLIGLVKTRTGNMD 419 +FW++P L A GIA I+S+G+ G SP LIG K TG++ Sbjct: 356 YSVFWAIPQQHLKGTAAAGGIALINSIGLFGGFFSPTLIGWTKEATGSLQ 405 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 341 bits (875), Expect = 2e-93, Method: Compositional matrix adjust. Identities = 184/439 (41%), Positives = 265/439 (60%), Gaps = 11/439 (2%) Query: 12 SATPSLAS----QAEDAIYRKVWLRIIPFLFICYVVSFLDRINIGFAQLQMKQDLGFSDA 67 S+T SL+ Q E+ YRK ++P L +CYV+++LDR+N+GFA+LQM DL FSD Sbjct: 4 SSTESLSQPTQLQEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQFSDT 63 Query: 68 MYGLGAAIFYVGYVLFEVPSNMALARFGARRTFSRIMVLWGLASVGMMAVTDAAHFYTLR 127 +YGLGA +F++GY E+PSN+ L R GAR +RIM+ WG+ S M VT FY +R Sbjct: 64 VYGLGAGMFFIGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFYVMR 123 Query: 128 FLLGVFEAGFFPGIVLYLSYWFLARRRAAVMAIFFAGVAVAGVLGGLVSGWIMRDMAGVM 187 FLLGV EAGFFPGI+LY+SYWF + RR V +F V ++G++G +SGWIM+ G Sbjct: 124 FLLGVAEAGFFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFNGFQ 183 Query: 188 GLYGWQWMFAIEGAPAVLLGLLAIFLLADGPAQAKWLSPEERSFLQARHQQEALRTHHVS 247 G GWQWMF +EG P+VL+G+L I+ L D A WL+ +E+ LQ + EA H Sbjct: 184 GYAGWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAAHYAH-- 241 Query: 248 GHSLAALRQALSHRTTYLFAFIYFALTCGSLTLNFWMPLMIRDFGIKDVVEVSLYSVIPN 307 + LR A +L IYF L G T+ FW+P +IRD G+KD++ + + IP+ Sbjct: 242 ----SRLRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPS 297 Query: 308 AIGAVGLILIARRSDRRNERHGHFAVCTTGGALALAALTLHPSSFAVSLGLLSVAAVLIF 367 A AV +I+++R +DR ER H A+ GA+ + T + V++ L++ A+ Sbjct: 298 AAAAVTMIVVSRSADRLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGAL 357 Query: 368 AALPIFWSLPPGLLPAQTIAPGIAFISSVGITSGIVSPWLIGLVKTRTGNMDIALYILAG 427 + +P+FWSLP L A GIAFI+S G G V+P+++G +K T + + I++ Sbjct: 358 STIPLFWSLPTAFLGGSAAAAGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLIIST 417 Query: 428 LLLLSGLAMWSLIPRKAAT 446 L + G A+ LIP KA Sbjct: 418 TLFI-GAALVFLIPAKAVN 435 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 337 bits (865), Expect = 3e-92, Method: Compositional matrix adjust. Identities = 184/432 (42%), Positives = 265/432 (61%), Gaps = 6/432 (1%) Query: 3 TPSPGGATLSATPSLASQAEDAIYRKVWLRIIPFLFICYVVSFLDRINIGFAQLQMKQDL 62 TP G + + P AS E+A YRKV R+IPFL +CYVV++LDR+N+GFA+LQM DL Sbjct: 5 TPPLGPSAGALPPQSASGFEEATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDL 64 Query: 63 GFSDAMYGLGAAIFYVGYVLFEVPSNMALARFGARRTFSRIMVLWGLASVGMMAVTDAAH 122 FS+ +YGLGA IF++GY LFEVPSN+ L R GAR +RIM+ WGL S MM VT A Sbjct: 65 KFSETVYGLGAGIFFIGYFLFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAM 124 Query: 123 FYTLRFLLGVFEAGFFPGIVLYLSYWFLARRRAAVMAIFFAGVAVAGVLGGLVSGWIMRD 182 FY +RFLLG+ EAGFFPGI+LYL+YW+ A RR F VA++GV+GG +SGW ++ Sbjct: 125 FYVMRFLLGLAEAGFFPGIILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKT 184 Query: 183 MAGVMGLYGWQWMFAIEGAPAVLLGLLAIFLLADGPAQAKWLSPEERSFLQARHQQEALR 242 GV GL GWQWMF IEG P+V++GL + L + + A+WL+ EE++ L E + Sbjct: 185 FGGVYGLAGWQWMFLIEGIPSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEEAQ 244 Query: 243 THHVSGHSLAALRQALSHRTTYLFAFIYFALTCGSLTLNFWMPLMIRDFGIKDVVEVSLY 302 A + ++ +L + IYF+ G ++FW+P +I+ G+ D + V L Sbjct: 245 KED------APIAAIMASPRVWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLL 298 Query: 303 SVIPNAIGAVGLILIARRSDRRNERHGHFAVCTTGGALALAALTLHPSSFAVSLGLLSVA 362 + IP V ++L+AR +DR ER H A+ GA+ L + ++ +++ L++ Sbjct: 299 TAIPYGAAVVAMVLVARSADRTRERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLG 358 Query: 363 AVLIFAALPIFWSLPPGLLPAQTIAPGIAFISSVGITSGIVSPWLIGLVKTRTGNMDIAL 422 + I LP+FWSLP L A GIA I+S+G +G +SP+ +G +K T + D + Sbjct: 359 TMGILTTLPLFWSLPTAFLAGTGAAAGIALINSLGNLAGFLSPYAVGWLKDTTRSTDSGM 418 Query: 423 YILAGLLLLSGL 434 Y+LA ++L L Sbjct: 419 YLLAASMVLGAL 430 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 315 bits (806), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 171/431 (39%), Positives = 253/431 (58%), Gaps = 9/431 (2%) Query: 4 PSPGGATLSATPSLASQ---AEDAIYRKVWLRIIPFLFICYVVSFLDRINIGFAQLQMKQ 60 P PG + + + + E+ YRKV RIIP L ICY++++LDR+N+GFA+LQM + Sbjct: 12 PLPGVKAMKNSNTAITSPEVVENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSE 71 Query: 61 DLGFSDAMYGLGAAIFYVGYVLFEVPSNMALARFGARRTFSRIMVLWGLASVGMMAVTDA 120 +LGFS+A+YGLGA +F++GY FE+PSN+ L + GAR +RIM+ WGL S V Sbjct: 72 ELGFSEAIYGLGAGLFFIGYFFFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTE 131 Query: 121 AHFYTLRFLLGVFEAGFFPGIVLYLSYWFLARRRAAVMAIFFAGVAVAGVLGGLVSGWIM 180 FY LRFLLG EAGF+PG++LYL+YWF + RR + A+F AG AG+ G +SGWIM Sbjct: 132 WQFYILRFLLGAAEAGFYPGVILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIM 191 Query: 181 RDMAGVMGLYGWQWMFAIEGAPAVLLGLLAIFLLADGPAQAKWLSPEERSFLQARHQQEA 240 G GWQWMF +E PAV+LG++ + L + AKWL+ EE++ + EA Sbjct: 192 DQFHDTAGWQGWQWMFVLEAIPAVVLGVVILLYLDNSVKAAKWLTEEEKAIIS--RDIEA 249 Query: 241 LRTHHVSGHSLAALRQALSHRTTYLFAFIYFALTCGSLTLNFWMPLMIRDFGIKDVVEVS 300 + HSL +L + + ++ IYF G L WMP +IR G+ V + Sbjct: 250 DSKGKAASHSLMSL---VKNPMLWVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIG 306 Query: 301 LYSVIPNAIGAVGLILIARRSDRRNERHGHFAVCTTGGALALAALTLHPSSFAVSLGLLS 360 L IP + +++ +R +D ER H V GA+ + ++ VS+ LS Sbjct: 307 LLGAIPFICAIIAMVIFSRSADHYRERRWHLVVPALLGAVGF-VVAASATNTTVSIIFLS 365 Query: 361 VAAVLIFAALPIFWSLPPGLLPAQTIAPGIAFISSVGITSGIVSPWLIGLVKTRTGNMDI 420 +AA + A P+FWSLP +L A GIA I+SV +G +SP+++G+++ T + ++ Sbjct: 366 MAAAGVLACAPLFWSLPTAILSGAAAAAGIALINSVANLAGFISPYMVGIIRDATHSSEL 425 Query: 421 ALYILAGLLLL 431 +Y+LAG L+L Sbjct: 426 GMYVLAGFLIL 436 >RSp0182 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 453 Score = 302 bits (773), Expect = 1e-81, Method: Compositional matrix adjust. Identities = 180/398 (45%), Positives = 237/398 (59%), Gaps = 10/398 (2%) Query: 18 ASQAEDAIYRKVWLRIIPFLFICYVVSFLDRINIGFAQLQMKQDLGFSDAMYGLGAAIFY 77 A+ E AI RK+ RI+PF+F Y++S+LDR NIG+A LQM Q+L S +G + IF+ Sbjct: 22 AAPDERAIVRKITWRILPFVFALYIISYLDRANIGYAALQMNQELALSSEAFGFVSGIFF 81 Query: 78 VGYVLFEVPSNMALARFGARRTFSRIMVLWGLASVGMMAVTDAAHFYTLRFLLGVFEAGF 137 +GY LFEVPSN+ L RFGARR +RI+V WGL ++G V A Y LRFLLGV EAGF Sbjct: 82 IGYFLFEVPSNLMLNRFGARRWIARILVTWGLVAMGSAFVQSATQLYALRFLLGVAEAGF 141 Query: 138 FPGIVLYLSYWFLARRRAAVMAIFFAGVAVAGVLGGLVSGWIMRDMAGVMGLYGWQWMFA 197 FPGI++YL+YWF AR A +A+F A + V+ V+G +S WIM D + GW+WM Sbjct: 142 FPGIIVYLTYWFRARELATTVALFTAAIPVSYVVGAPLSTWIM-DHVHWLQWSGWRWMLL 200 Query: 198 IEGAPAVLLGLLAIFLLADGPAQAKWLSPEERSFLQARHQQEALRTHHVSGHSLAALRQA 257 +EGAPAV+ GLL LAD P A+WLS ER +L A +++ R + LA L+ Sbjct: 201 LEGAPAVIGGLLCYGYLADRPKDARWLSEAERDWLLAELERD--RKARPAAAHLATLKVM 258 Query: 258 LSHRTTYLFAFIYFALTCGSLTLNFWMPLMIRDFGIK-DVVEVSLYSVIPNAIGAVGLIL 316 R YL AFIYF CGSL + +WMP +I+ F EV L +++P +I Sbjct: 259 THPRVLYL-AFIYFVYQCGSLGIGYWMPQIIKGFSSALSHTEVGLIAMLPYVFATAVMIW 317 Query: 317 IARRSDRRNERHGHFAVCTTGGALAL--AALTLHPSSFAVSLGLLSVAAVLIFAALPIFW 374 +RRSD R ER H AV ALA A HP AV++ +LS++ ++A FW Sbjct: 318 WSRRSDLRAERRLHSAVPLGVAALAFVGAGFIGHP---AVAMAMLSLSLAGLYAFKSPFW 374 Query: 375 SLPPGLLPAQTIAPGIAFISSVGITSGIVSPWLIGLVK 412 +LP L T A IA I+SVG G V P+ IG K Sbjct: 375 ALPTLFLTRSTAAVSIAVINSVGNLGGFVGPFAIGYFK 412