BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0011.0058.p (488 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value yebQ [GEPR] COG0477 Permeases of the major facilitator superfami... 315 2e-85 Z2875 [GEPR] COG0477 Permeases of the major facilitator superfam... 315 2e-85 ECs2538 [GEPR] COG0477 Permeases of the major facilitator superf... 315 2e-85 YPO1712 [GEPR] COG0477 Permeases of the major facilitator superf... 311 3e-84 BMEII0280 [GEPR] COG0477 Permeases of the major facilitator supe... 306 1e-82 >yebQ [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 494 Score = 315 bits (806), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 183/436 (41%), Positives = 259/436 (59%), Gaps = 16/436 (3%) Query: 1 LPIPAMELFSDHPNDEGLPGKQRRRAMLAVMTATTMAVFDGTIINVALPQISQALQTSAA 60 +P+P ++ +GLP QR A+L ++ +MAV DG I NVALP I+ L + A Sbjct: 36 IPMPKVQ-------ADGLPLPQRYGAILTIVIGISMAVLDGAIANVALPTIATDLHATPA 88 Query: 61 VSIWVSNAYLLATAMTLAAFAALSSRIGFRAQFSAGLAVFTLASLGCALSGSVTLLILMR 120 SIWV NAY +A ++L +F+ L G+R + GL VF L+SL CALS S+ +L L R Sbjct: 89 SSIWVVNAYQIAIVISLLSFSFLGDMFGYRRIYKCGLVVFLLSSLFCALSDSLQMLTLAR 148 Query: 121 ILQGLGGAAMLSIAPAIHRTIFPNRLLGRILGLNA-VXAASTAVGPVLGGTLLATLGWEW 179 ++QG GGAA++S+ A+ R I+P R LGR +G+N+ + A S+A GP + +L+ W+W Sbjct: 149 VIQGFGGAALMSVNTALIRLIYPQRFLGRGMGINSFIVAVSSAAGPTIAAAILSIASWKW 208 Query: 180 IFAINVPLGVLAVWLAWNAVP-DTRKPAQAAFDLAGALWSALAMGALIMAADTCARFAEP 238 +F INVPLG++A+ LA +P + + ++ FDL A+ +AL G LI A A Sbjct: 209 LFLINVPLGIIALLLAMRFLPPNGSRASKPRFDLPSAVMNALTFGLLITALSGFA----- 263 Query: 239 GQGSEAAFTAAAYAVTALLAGLAFVRGQRRAADPLLPLDIFANPRFSLAALTSLASFVGQ 298 QG AA V ++ G+ F+R Q PLLP+D+ P FSL+ TS+ SF Q Sbjct: 264 -QGQSLTLIAAELVVMVVV-GIFFIRRQLSLPVPLLPVDLLRIPLFSLSICTSVCSFCAQ 321 Query: 299 GIAFVALPFLFQNAYGYTAFESAALFTPWPLGIVLVAPHAGRLADRHSPALLSSLGLALF 358 +A V+LPF Q G + E+ L TPWPL +++AP AG L +R LL +LGL + Sbjct: 322 MLAMVSLPFYLQTVLGRSEVETGLLLTPWPLATMVMAPLAGYLIERVHAGLLGALGLFIM 381 Query: 359 ALGLVLLALLPDQAQPWDIGWRALVCGMGFGFFQSPNNREMLGNVSRERSGNASGVLAIM 418 A GL L LLP +I W ++CG GFG FQSPNN ++ + RERSG ASG+L Sbjct: 382 AAGLFSLVLLPASPADINIIWPMILCGAGFGLFQSPNNHTIITSAPRERSGGASGMLGTA 441 Query: 419 RTFGQCLGAALLGVIL 434 R GQ GAAL+ ++L Sbjct: 442 RLLGQSSGAALVALML 457 >Z2875 [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 494 Score = 315 bits (806), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 183/436 (41%), Positives = 259/436 (59%), Gaps = 16/436 (3%) Query: 1 LPIPAMELFSDHPNDEGLPGKQRRRAMLAVMTATTMAVFDGTIINVALPQISQALQTSAA 60 +P+P ++ +GLP QR A+L ++ +MAV DG I NVALP I+ L + A Sbjct: 36 IPMPKVQ-------ADGLPLPQRYGAILTIVIGISMAVLDGAIANVALPTIATDLHATPA 88 Query: 61 VSIWVSNAYLLATAMTLAAFAALSSRIGFRAQFSAGLAVFTLASLGCALSGSVTLLILMR 120 SIWV NAY +A ++L +F+ L G+R + GL VF L+SL CALS S+ +L L R Sbjct: 89 SSIWVVNAYQIAIVISLLSFSFLGDMFGYRRIYKCGLVVFLLSSLFCALSDSLQILTLAR 148 Query: 121 ILQGLGGAAMLSIAPAIHRTIFPNRLLGRILGLNA-VXAASTAVGPVLGGTLLATLGWEW 179 ++QG GGAA++S+ A+ R I+P R LGR +G+N+ + A S+A GP + +L+ W+W Sbjct: 149 VIQGFGGAALMSVNTALIRLIYPQRFLGRGMGINSFIVAVSSAAGPTIAAAILSIASWKW 208 Query: 180 IFAINVPLGVLAVWLAWNAVP-DTRKPAQAAFDLAGALWSALAMGALIMAADTCARFAEP 238 +F INVPLG++A+ LA +P + + ++ FDL A+ +AL G LI A A Sbjct: 209 LFLINVPLGIIALLLAMRFLPPNGSRASKPRFDLPSAVMNALTFGLLITALSGFA----- 263 Query: 239 GQGSEAAFTAAAYAVTALLAGLAFVRGQRRAADPLLPLDIFANPRFSLAALTSLASFVGQ 298 QG AA V ++ G+ F+R Q PLLP+D+ P FSL+ TS+ SF Q Sbjct: 264 -QGQSLTLIAAELVVMVVV-GIFFIRRQLSLPVPLLPVDLLRIPLFSLSICTSVCSFCAQ 321 Query: 299 GIAFVALPFLFQNAYGYTAFESAALFTPWPLGIVLVAPHAGRLADRHSPALLSSLGLALF 358 +A V+LPF Q G + E+ L TPWPL +++AP AG L +R LL +LGL + Sbjct: 322 MLAMVSLPFYLQTVLGRSEVETGLLLTPWPLATMVMAPLAGYLIERVHAGLLGALGLFIM 381 Query: 359 ALGLVLLALLPDQAQPWDIGWRALVCGMGFGFFQSPNNREMLGNVSRERSGNASGVLAIM 418 A GL L LLP +I W ++CG GFG FQSPNN ++ + RERSG ASG+L Sbjct: 382 AAGLFSLVLLPASPADINIIWPMILCGAGFGLFQSPNNHTIITSAPRERSGGASGMLGTA 441 Query: 419 RTFGQCLGAALLGVIL 434 R GQ GAAL+ ++L Sbjct: 442 RLLGQSSGAALVALML 457 >ECs2538 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 494 Score = 315 bits (806), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 183/436 (41%), Positives = 259/436 (59%), Gaps = 16/436 (3%) Query: 1 LPIPAMELFSDHPNDEGLPGKQRRRAMLAVMTATTMAVFDGTIINVALPQISQALQTSAA 60 +P+P ++ +GLP QR A+L ++ +MAV DG I NVALP I+ L + A Sbjct: 36 IPMPKVQ-------ADGLPLPQRYGAILTIVIGISMAVLDGAIANVALPTIATDLHATPA 88 Query: 61 VSIWVSNAYLLATAMTLAAFAALSSRIGFRAQFSAGLAVFTLASLGCALSGSVTLLILMR 120 SIWV NAY +A ++L +F+ L G+R + GL VF L+SL CALS S+ +L L R Sbjct: 89 SSIWVVNAYQIAIVISLLSFSFLGDMFGYRRIYKCGLVVFLLSSLFCALSDSLQILTLAR 148 Query: 121 ILQGLGGAAMLSIAPAIHRTIFPNRLLGRILGLNA-VXAASTAVGPVLGGTLLATLGWEW 179 ++QG GGAA++S+ A+ R I+P R LGR +G+N+ + A S+A GP + +L+ W+W Sbjct: 149 VIQGFGGAALMSVNTALIRLIYPQRFLGRGMGINSFIVAVSSAAGPTIAAAILSIASWKW 208 Query: 180 IFAINVPLGVLAVWLAWNAVP-DTRKPAQAAFDLAGALWSALAMGALIMAADTCARFAEP 238 +F INVPLG++A+ LA +P + + ++ FDL A+ +AL G LI A A Sbjct: 209 LFLINVPLGIIALLLAMRFLPPNGSRASKPRFDLPSAVMNALTFGLLITALSGFA----- 263 Query: 239 GQGSEAAFTAAAYAVTALLAGLAFVRGQRRAADPLLPLDIFANPRFSLAALTSLASFVGQ 298 QG AA V ++ G+ F+R Q PLLP+D+ P FSL+ TS+ SF Q Sbjct: 264 -QGQSLTLIAAELVVMVVV-GIFFIRRQLSLPVPLLPVDLLRIPLFSLSICTSVCSFCAQ 321 Query: 299 GIAFVALPFLFQNAYGYTAFESAALFTPWPLGIVLVAPHAGRLADRHSPALLSSLGLALF 358 +A V+LPF Q G + E+ L TPWPL +++AP AG L +R LL +LGL + Sbjct: 322 MLAMVSLPFYLQTVLGRSEVETGLLLTPWPLATMVMAPLAGYLIERVHAGLLGALGLFIM 381 Query: 359 ALGLVLLALLPDQAQPWDIGWRALVCGMGFGFFQSPNNREMLGNVSRERSGNASGVLAIM 418 A GL L LLP +I W ++CG GFG FQSPNN ++ + RERSG ASG+L Sbjct: 382 AAGLFSLVLLPASPADINIIWPMILCGAGFGLFQSPNNHTIITSAPRERSGGASGMLGTA 441 Query: 419 RTFGQCLGAALLGVIL 434 R GQ GAAL+ ++L Sbjct: 442 RLLGQSSGAALVALML 457 >YPO1712 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 455 Score = 311 bits (796), Expect = 3e-84, Method: Compositional matrix adjust. Identities = 181/423 (42%), Positives = 248/423 (58%), Gaps = 9/423 (2%) Query: 14 NDEGLPGKQRRRAMLAVMTATTMAVFDGTIINVALPQISQALQTSAAVSIWVSNAYLLAT 73 +GLP QR A+L + MAV DGTI NVALP I++ L TS A SIWV NAY LA Sbjct: 5 TSDGLPVPQRYAAILVIALGIMMAVLDGTIANVALPTIARDLNTSPATSIWVVNAYQLAI 64 Query: 74 AMTLAAFAALSSRIGFRAQFSAGLAVFTLASLGCALSGSVTLLILMRILQGLGGAAMLSI 133 ++L + A+L IG+R + AGL +F++ SL CALS S+ L R+LQG G AA++S+ Sbjct: 65 TISLLSMASLGDIIGYRRVYQAGLLIFSVTSLFCALSDSLWTLTFARVLQGFGAAALMSV 124 Query: 134 APAIHRTIFPNRLLGRILGLNA-VXAASTAVGPVLGGTLLATLGWEWIFAINVPLGVLAV 192 A+ R I+P LGR +G+N + A S+A GP + +L+ W+W+FA+NVP+G+LA Sbjct: 125 NTALIRIIYPRAQLGRGIGINTLIVAVSSAAGPSIAAAVLSVASWQWLFALNVPIGLLAW 184 Query: 193 WLAWNAVP-DTRKPAQAAFDLAGALWSALAMGALIMAADTCARFAEPGQGSEAAFTAAAY 251 L +P + K FD+ + +AL G LI A ++ P AA Sbjct: 185 CLGIKFLPANNTKSNGNRFDITSCVLNALTFGLLITAISGFSQGQSPA-------VIAAQ 237 Query: 252 AVTALLAGLAFVRGQRRAADPLLPLDIFANPRFSLAALTSLASFVGQGIAFVALPFLFQN 311 V LL G FVR Q + PLLP+D+ P F+L+ TS+ SF Q +A V+LPF Q Sbjct: 238 VVALLLIGFFFVRRQLTQSFPLLPVDLLRIPIFALSIGTSIFSFAAQMLAMVSLPFFLQT 297 Query: 312 AYGYTAFESAALFTPWPLGIVLVAPHAGRLADRHSPALLSSLGLALFALGLVLLALLPDQ 371 G + L TPWPL +++AP AGRL +R+ LL +GLA+FA GL LLA+LP Sbjct: 298 VLGRDEVATGLLLTPWPLATMVIAPIAGRLVERYHAGLLGGIGLAVFASGLFLLAVLPAN 357 Query: 372 AQPWDIGWRALVCGMGFGFFQSPNNREMLGNVSRERSGNASGVLAIMRTFGQCLGAALLG 431 DI WR ++CG GFG FQ+PNN ++ + RSG ASG+L R GQ GAAL+ Sbjct: 358 PSDVDIIWRMILCGAGFGLFQTPNNHTIISAAPQHRSGGASGMLGTARLLGQTSGAALVA 417 Query: 432 VIL 434 ++ Sbjct: 418 LMF 420 >BMEII0280 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 463 Score = 306 bits (783), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 193/468 (41%), Positives = 272/468 (58%), Gaps = 25/468 (5%) Query: 16 EGLPGKQRRRAMLAVMTATTMAVFDGTIINVALPQISQALQTSAAVSIWVSNAYLLATAM 75 +GLP + A +M T+AV DGTI NVALP I+ A SIW+ N Y LA + Sbjct: 20 DGLPRPRIYWAWATLMVGLTLAVIDGTIANVALPTIAADFSAGPAASIWIVNGYQLAIVI 79 Query: 76 TLAAFAALSSRIGFRAQFSAGLAVFTLASLGCALSGSVTLLILMRILQGLGGAAMLSIAP 135 T+ AAL G+R + AG+A+FT+AS+GC S S+ L L RI+QGLG A ++S+ Sbjct: 80 TMLPLAALGEIYGYRRVYVAGVALFTIASIGCVFSRSLEALTLARIIQGLGAAGLMSVNT 139 Query: 136 AIHRTIFPNRLLGRILGLNAV-XAASTAVGPVLGGTLLATLGWEWIFAINVPLGVLAVWL 194 A+ R P G +GLNA+ A S+ +GP L G +L++L W W+F IN+PLG+ AV + Sbjct: 140 ALLRYTVPQAKFGTAIGLNALFVAVSSTIGPSLAGVMLSSLSWPWLFVINIPLGIAAVLM 199 Query: 195 AWNAVPDTRKPAQAAFDLAGALWSALAMGALIMAADTCARFAEPGQGSEAAFTAAAYAVT 254 ++PD + A+ FD+ A+ A+ G LI D+ A GS A A + Sbjct: 200 GLRSLPDNDRSARK-FDVVSAILCAVTFGLLITTIDS----AGNKIGSLAVMLQA---LC 251 Query: 255 ALLAGLAFVRGQRRAADPLLPLDIFANPRFSLAALTSLASFVGQGIAFVALPFLFQNAYG 314 LLAG+ R +DPLLPLD+ P F+L+ TS+ SF+ Q +AF++LPFLFQ +G Sbjct: 252 CLLAGIWLTRRSFHMSDPLLPLDLLRIPVFTLSICTSIMSFLAQMMAFISLPFLFQTVFG 311 Query: 315 YTAFESAALFTPWPLGIVLVAPHAGRLADRHSPALLSSLGLALFALGLVLLALLPDQAQP 374 + E L PWP+ + LVAP +G+L+D++SPA+L LGL F++GL L+ LLP Sbjct: 312 FRPIEVGFLMMPWPIALALVAPLSGKLSDKYSPAILGLLGLITFSVGLALVGLLPGHPTI 371 Query: 375 WDIGWRALVCGMGFGFFQSPNNREMLGNVSRERSGNASGVLAIMRTFGQCLGAALLGVIL 434 DI WR +CG+GFG FQ+PNNR M+ + R RSG ASG+L R GQ +GAAL+ +L Sbjct: 372 PDICWRMAICGIGFGLFQAPNNRMMITSTPRARSGAASGMLGTARLLGQSVGAALVAFLL 431 Query: 435 AVRTAAAVAQGELQMNPVQDGEAIRIALWLAAAATALATAVSASRLRR 482 +Q ++ P L+LA+ A+ +S SRLR Sbjct: 432 --------SQWGVEGTPY--------ILFLASGFALFASVISISRLRH 463