BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0011.0051.p (488 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_ycbE [GEPR] COG0477 Permeases of the major facilitator superf... 158 2e-38 SA2300 [GEPR] COG0477 Permeases of the major facilitator superfa... 156 9e-38 ZyjiZ [GEPR] COG0477 Permeases of the major facilitator superfam... 145 3e-34 ECs5316 [GEPR] COG0477 Permeases of the major facilitator superf... 145 3e-34 RSp1614 [GEPR] COG0477 Permeases of the major facilitator superf... 144 4e-34 >BS_ycbE [GEPR] COG0477 Permeases of the major facilitator superfamily Bsu Bacillus subtilis Length = 455 Score = 158 bits (400), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 124/457 (27%), Positives = 216/457 (47%), Gaps = 34/457 (7%) Query: 44 KPTRYRWVVMGLIFLIWAIACADRANFGIALPYMKKEYGITNTEAGLIVSLFSFAYGLVQ 103 K T RW ++ ++FL+ +I ADRA I ++ + G+ + G + S F +AY + Q Sbjct: 13 KKTSVRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQ 72 Query: 104 IPVGLMYKRLSEKTT---GILFSVFMLLTSLFTGLMGTTSSVLLLQLYRVGLGLSEGPLG 160 +P G + R KT I F F L G ++++LL R +GLSE P Sbjct: 73 LPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAIGFFSAGTAIILLFALRFLVGLSEAPSF 132 Query: 161 IGCTNVINRWFPPEEKGTATGLWIAASKLGPLIVPTVCIIVIQLWGWREIFYVFAVPGIF 220 G V+ WFP E+GTA+ + +A +I P + + +GW +F V + GI Sbjct: 133 PGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFPPLMGWLTHSFGWHSVFVVMGIAGIL 192 Query: 221 LAILWFFLVTNSPSENRFCNEAERRYITQDVAAGPATASSRAHVGAQVTPMPWLDGINRT 280 LA++W V P ++ NEAE YI Q G + M D ++ Sbjct: 193 LAVIWLKTVYE-PKKHPKVNEAELAYIEQ---------------GGGLISMD--DSKSKQ 234 Query: 281 RRVPRLETLRQVFTSWNVIGVAIGYGCMIGISNIFMSWIPTYLVTVKGFASVKMGFLASA 340 + ++Q+ T+ +IGV I C+ ++ F++W P YLV +G + ++ GF+AS Sbjct: 235 ETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASL 294 Query: 341 PFIGAVAGNMLGGVISDRLL-GGR-----RKPMMLLGALGTALMTLLLVEAPDSVLYLGA 394 P + AG +LGG++SD LL GR RK ++ G L + ++++ DS + Sbjct: 295 PALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLLSC--SMIVCNYTDSAWLVVV 352 Query: 395 MLMFSGLMLGIGFAGYSAYPMGLATKATYPAAFGIVNSLGQIGGACAPLAVGMLLDRYDW 454 ++ + G G G+ A + K + G+ N+ G I P+ +G +++ Sbjct: 353 IMSLAFFGKGFGALGW-AVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGS 411 Query: 455 SSVFLYMVGTS----LLCLVLLLSVVEPITVRKAGEE 487 + L VG + +L +LL+ ++ + ++K ++ Sbjct: 412 FNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQD 448 >SA2300 [GEPR] COG0477 Permeases of the major facilitator superfamily Sau Staphylococcus aureus N315 Length = 425 Score = 156 bits (395), Expect = 9e-38, Method: Compositional matrix adjust. Identities = 120/456 (26%), Positives = 208/456 (45%), Gaps = 44/456 (9%) Query: 43 QKPTRYRWVVMGLIFLIWAIACADRANFGIALPYMKKEYGITNTEAGLIVSLFSFAYGLV 102 +K T RW+ F I IA DRAN M + G+T + GL+ S FS Y L+ Sbjct: 3 EKRTNVRWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALM 62 Query: 103 QIPVGLMYKRLSEKTTGILFSVFMLLTSLFTGLMGTTSSVLLLQLYRVGLGLSEGPLGIG 162 Q+P G++ ++ + + ++ ++ S FT L G + L+ L R G+ E P+ Sbjct: 63 QVPSGMLAEKFGPRK---MITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPS 119 Query: 163 CTNVINRWFPPEEKGTATGLWIAASKLGPLIVPTVCIIVIQLWGWREIFYVFAVPGIFLA 222 + WF EKG A+ +A S GP++ P V I ++ + W+ +FY+F GI +A Sbjct: 120 NAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMA 179 Query: 223 ILWFFLVTNSPSENRFCNEAERRYITQDVAAGPATASSRAHVGAQVTPMPWLDGINRTRR 282 +LW + + P ++R NEAE+R+I ++ R V + + PW Sbjct: 180 VLWAIIAKDLPEQHRMVNEAEKRFIMEN----------RDIVATEKSSPPW--------- 220 Query: 283 VPRLETLRQVFTSWNVIGVAIGYGCMIGISNIFMSWIPTYLVTVKGFASVKMGFLASAPF 342 F ++ +AI Y + I +F+ W+PTYL V +M ++S P+ Sbjct: 221 -------NNFFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMS-ISSLPW 272 Query: 343 IGAVAGNMLGGVISDRLLGGRRKPMMLLGALGTALMTLLLVEAPDSV----LYLGAMLM- 397 + + G ISDR+LG R + G + A + V +V LY+ + Sbjct: 273 LLMFFLILSAGAISDRVLGLGRSKFVARGVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLS 332 Query: 398 --FSGLMLGIGFAGYSAYPMGLATKATYPAAFGIVNSLGQIGGACAPLAVGMLLDRYDWS 455 G+ + +G + +A +G T G +N G IG +PL G+ ++ W+ Sbjct: 333 LGLGGIGISMGMSWAAATDLGRNFSGTVS---GWMNLWGNIGALISPLLAGLFVEHLGWT 389 Query: 456 SVFLYMVGTSLLCLVLLLSVV--EPITV--RKAGEE 487 F ++ +++ +++ V +P+ V KA E+ Sbjct: 390 MTFQLLIVPAVIAVIMWFYVKPDQPLIVSDDKAIEK 425 >ZyjiZ [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 453 Score = 145 bits (365), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 119/444 (26%), Positives = 210/444 (47%), Gaps = 45/444 (10%) Query: 18 SVAPAASAASAVSAASNAPAAAQIGQKPTRYRWV---VMGLIFLIWAIACADRANFGIAL 74 ++ P +S + SA P + Q+ TR + + M L+F I DR++ +A Sbjct: 7 TLDPRSSFTPSSSADIPVPPDGLV-QRSTRIKRIQTTAMLLLFFAAVINYLDRSSLSVAN 65 Query: 75 PYMKKEYGITNTEAGLIVSLFSFAYGLVQIPVGLMYKRLSEKTTGILFSVFMLLTSLFTG 134 +++E G++ TE G ++S+FS AYG+ Q+P G + R K ++ + M SLF Sbjct: 66 LTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDR---KGPRLMLGLGMFFWSLFQA 122 Query: 135 LMGTTSSVLLLQLYRVGLGLSEGPLGIGCTNVINRWFPPEEKGTATGLWIAASKLGPLIV 194 + G S L R+G+G+ E P+ VIN WF +E+G G + AAS +G + Sbjct: 123 MSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVS 182 Query: 195 PTVCIIVIQLWGWREIFYVFAVPGIFLAILWFFLVTNSPSENRFCNEAERRYITQDVAAG 254 P + ++ + GWR +F V GIFLAI W+ L N R ++ Sbjct: 183 PPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLYRN------------REHVE------ 224 Query: 255 PATASSRAHVGAQVTPMPWLDGINRTRRVPRLETLRQVFTSWNVIGVAIGYGCMIGISNI 314 TA +A++ A +N R R +F + + G+ +G+ + + + Sbjct: 225 -LTAVEQAYLNA--------GSVNARRDPLSFAEWRSLFRNRTMWGMMLGFSGINYTAWL 275 Query: 315 FMSWIPTYLVTVKGFASVKMGFLASAPFIGAVAGNMLGGVISDRLLGG------RRKPMM 368 +++W+P YL T G +A+ PF+ AG ++ G ++D L+ G RK + Sbjct: 276 YLAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLVKGGMAPIKSRKICI 335 Query: 369 LLGALGTALMTLLLVEAPDSVLYLGAMLMFSGLMLGIGFAGYSAYPM-GLATKATYPAAF 427 + G +A TL++ +A S++ A+L+ + I FAG S + + +A + A+ Sbjct: 336 IAGMFCSAAFTLIVPQATTSMM---AVLLIGMALFCIHFAGTSCWGLIHVAVASRMTASV 392 Query: 428 GIVNSLGQ-IGGACAPLAVGMLLD 450 G + + I + AP+ G ++D Sbjct: 393 GSIQNFASFICASFAPIITGFIVD 416 >ECs5316 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 453 Score = 145 bits (365), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 119/444 (26%), Positives = 210/444 (47%), Gaps = 45/444 (10%) Query: 18 SVAPAASAASAVSAASNAPAAAQIGQKPTRYRWV---VMGLIFLIWAIACADRANFGIAL 74 ++ P +S + SA P + Q+ TR + + M L+F I DR++ +A Sbjct: 7 TLDPRSSFTPSSSADIPVPPDGLV-QRSTRIKRIQTTAMLLLFFAAVINYLDRSSLSVAN 65 Query: 75 PYMKKEYGITNTEAGLIVSLFSFAYGLVQIPVGLMYKRLSEKTTGILFSVFMLLTSLFTG 134 +++E G++ TE G ++S+FS AYG+ Q+P G + R K ++ + M SLF Sbjct: 66 LTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDR---KGPRLMLGLGMFFWSLFQA 122 Query: 135 LMGTTSSVLLLQLYRVGLGLSEGPLGIGCTNVINRWFPPEEKGTATGLWIAASKLGPLIV 194 + G S L R+G+G+ E P+ VIN WF +E+G G + AAS +G + Sbjct: 123 MSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVS 182 Query: 195 PTVCIIVIQLWGWREIFYVFAVPGIFLAILWFFLVTNSPSENRFCNEAERRYITQDVAAG 254 P + ++ + GWR +F V GIFLAI W+ L N R ++ Sbjct: 183 PPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLYRN------------REHVE------ 224 Query: 255 PATASSRAHVGAQVTPMPWLDGINRTRRVPRLETLRQVFTSWNVIGVAIGYGCMIGISNI 314 TA +A++ A +N R R +F + + G+ +G+ + + + Sbjct: 225 -LTAVEQAYLNA--------GSVNARRDPLSFAEWRSLFRNRTMWGMMLGFSGINYTAWL 275 Query: 315 FMSWIPTYLVTVKGFASVKMGFLASAPFIGAVAGNMLGGVISDRLLGG------RRKPMM 368 +++W+P YL T G +A+ PF+ AG ++ G ++D L+ G RK + Sbjct: 276 YLAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLVKGGMAPIKSRKICI 335 Query: 369 LLGALGTALMTLLLVEAPDSVLYLGAMLMFSGLMLGIGFAGYSAYPM-GLATKATYPAAF 427 + G +A TL++ +A S++ A+L+ + I FAG S + + +A + A+ Sbjct: 336 IAGMFCSAAFTLIVPQATTSMM---AVLLIGMALFCIHFAGTSCWGLIHVAVASRMTASV 392 Query: 428 GIVNSLGQ-IGGACAPLAVGMLLD 450 G + + I + AP+ G ++D Sbjct: 393 GSIQNFASFICASFAPIITGFIVD 416 >RSp1614 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 448 Score = 144 bits (363), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 124/451 (27%), Positives = 212/451 (47%), Gaps = 42/451 (9%) Query: 40 QIGQKPTRYRWVVMGLIFLIWAIACADRANFGIALPYMKKEYGITNTEAGLIVSLFSFAY 99 Q GQ+ ++ RW+V GL++ AI DR A P+++KE+ ++ E G+++S F ++Y Sbjct: 6 QRGQR-SKVRWLVAGLMWAAIAINYIDRTVLSAAAPHIQKEFHLSAVEMGVVMSAFFWSY 64 Query: 100 GLVQIPVGLMYKRLSEKTTGILFSVFMLLTSLFTGLMGTTSSVLLLQLYRVGLGLSEGPL 159 L+Q+P G++ R +K + F+V L SL T + G + L RV LG+ E Sbjct: 65 ALLQLPAGILADRFGQKKV-LGFAV--LWWSLATAVTGLATGFKSLVGLRVALGVGEAGA 121 Query: 160 GIGCTNVINRWFPPEEKGTATGLWIAASKLGPLIVPTVCIIVIQLWGWREIFYVFAVPGI 219 + +RWFP +E+ T ++ + SKLG I + ++ + W+ F V GI Sbjct: 122 YPSNAGITSRWFPKQERATVAAIFDSGSKLGSAIALPLIAWLLVTFDWKITFTVAGSLGI 181 Query: 220 FLAILWFFLVTNSPSENRFCNEAERRYITQDVAAGPATASSRAHVGAQVTPMPWLDGINR 279 ++W + +SP+E+ N AE +I + + PA GA MPW Sbjct: 182 VWCVVWALVFRDSPAEHEGVNAAELAHIQKGLP--PAR-------GADAPAMPW------ 226 Query: 280 TRRVPRLETLRQVFTSWNVIGVAIGYGCMIGISNIFMSWIPTYLVTVKGFASVKMGFLAS 339 ++ T NV + IG+ + S F++W+PTYLV +G ++MGF+AS Sbjct: 227 ----------TKLLTHRNVWAMCIGFFMINYNSYFFITWLPTYLVKERGMGLMEMGFMAS 276 Query: 340 APFIGAVAGNMLGGVISDRL-------LGGRRKPMMLLGALGTALMTLLLVEAPDSVLYL 392 P ++ + G SDR+ L RK +++G + + + L V + Sbjct: 277 LPLFVSMFVEVFAGWASDRVYASGRLSLTATRKLFLVIGLVMASSIGLAAFAQSAVVAVI 336 Query: 393 GAMLMFSGLMLGIGFAGYSAYPMGLATKATYPAAFGIVNSLGQIGGACAPLAVGMLL--- 449 + SG + + A P +A T G+ NS+ +GG P+ G ++ Sbjct: 337 LLCIAKSGTT--VAASQVWALPADVAPGNTVSMVAGLQNSVSNMGGVVGPIVTGAIVGAT 394 Query: 450 DRYDWSSVF-LYMVGTSLLCLVLLLSVVEPI 479 + + VF ++G ++L + LL VEPI Sbjct: 395 GSFIPALVFSAALIGLAILNYLFLLGKVEPI 425