BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0011.0017.p (550 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value VCA0895_2 [T] COG2206 HD-GYP domain Vch Vibrio cholerae 375 e-103 CAC2837 [T] COG2206 HD-GYP domain Cac Clostridium acetobutylicum 81 7e-15 VCA0681 [T] COG2206 HD-GYP domain Vch Vibrio cholerae 77 1e-13 TM0037 [T] COG2206 HD-GYP domain Tma Thermotoga maritima 73 2e-12 alr3920 [KT] COG3437 Response regulator containing a CheY-like r... 72 3e-12 >VCA0895_2 [T] COG2206 HD-GYP domain Vch Vibrio cholerae Length = 464 Score = 375 bits (962), Expect = e-103, Method: Compositional matrix adjust. Identities = 204/446 (45%), Positives = 280/446 (62%), Gaps = 15/446 (3%) Query: 98 LRGRNGSLEGLLVLVHAHDSAHGDPRFLAFARRLSGMLAVAIETRQLIAAQKALLESLIR 157 L R L G++ L + + AF R L +A + I QK +L++ + Sbjct: 18 LLNRERQLVGIVCLGYERTIENVQADKHAFLRELLSFAEIAKDNIDKIQQQKEMLKAFVE 77 Query: 158 LMADAIDAKSPYTGGHCERVPHLAIMLVERLAQEREGPYAGFSLNEDERYAFRLAALLHD 217 L+A AID KSPYTGGHC+RVP L +L E A+++ +A F+++ ++ LAA LHD Sbjct: 78 LIASAIDTKSPYTGGHCQRVPELTRLLAEAAAKDKRY-FAEFTMSSEQWEELTLAAWLHD 136 Query: 218 CGKVTSPEHIVDKATKLEVIHNRIHEVRMRFEVLWRDAELALLHQLPQALSEQQA-QALE 276 CGKVT+PE +VDKATKLE I++RIHEVRMRFE+L AE Q +QA QAL+ Sbjct: 137 CGKVTTPEFVVDKATKLETIYDRIHEVRMRFELLKMQAERDYWQSCAQGGDPKQAEQALK 196 Query: 277 AQRARLREDFAFVAQCNVGSEAMSEEAIARLARIATQTWERHFDDSLGLAAEEARRLAAT 336 A +L ++FAFVAQCN+GSE MS+E I RL +IA + W+R DD +G++ E R AA Sbjct: 197 ALHQQLDDEFAFVAQCNLGSEGMSDEDIKRLEQIAQRQWQRTLDDQIGISWVEKSRAAA- 255 Query: 337 RQGQAAQVLPVTEPLLADRPEHIVPWDEEHRPAVERGDPRNTLGFDMTLPRYRQNMGELH 396 LPV EPLLAD+ H +PW + P + F +T P + N GELH Sbjct: 256 -----PAPLPVWEPLLADKSVHQIPWPQGKTPQETWQE-----AFCLTPPALQYNRGELH 305 Query: 397 NLGIRRGTLTPEDRFAINNHIVQTLVMLKSLPWPESLKSVPDTAANHHEKMDGTGYPRRL 456 NL ++RGTLT EDRF IN+HI+QT++ML+ LP+P+ L+ VP+ A HHE+MDG GYPR + Sbjct: 306 NLKVKRGTLTAEDRFMINDHIIQTILMLQRLPYPKHLQGVPEIAGGHHERMDGKGYPRGI 365 Query: 457 KASELPLQDRVMALADVFEALTAADRPYKPAKTLSESLRIMANMCRERHLDTELFRYFLR 516 +AS+L + R+MA+ADVFEALT+ DRPYK AK+L E + IM +M H+D +L+ FL+ Sbjct: 366 EASQLSVPARIMAIADVFEALTSNDRPYKKAKSLQECIAIMTDMATSGHIDPKLYLLFLQ 425 Query: 517 SRLWEVYAGELL--KEGQIDAVDIVE 540 L + YA + L ++ Q VD E Sbjct: 426 HNLHQTYAEQFLSVEQYQNSVVDTQE 451 >CAC2837 [T] COG2206 HD-GYP domain Cac Clostridium acetobutylicum Length = 417 Score = 80.9 bits (198), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 42/123 (34%), Positives = 74/123 (60%), Gaps = 13/123 (10%) Query: 393 GELHNLGI---------RRGTLTPEDRFAINNHIVQTLVMLKSLPWPESLKSVPDTAANH 443 G LH++G + G+LT ++ I +H+ T ++L S+ E + + A++H Sbjct: 277 GLLHDIGKLAIPTSILDKNGSLTDDEFSIIKSHVYYTKIILDSI---EDIHDISYWASSH 333 Query: 444 HEKMDGTGYPRRLKASELPLQDRVMALADVFEALTAADRPYKPAKTLSESLRIMANMCRE 503 HEK++GTGYPR L ASEL + R+M + D+++ALT DRPY+ + E+ +I+ +M + Sbjct: 334 HEKLNGTGYPRHLTASELSEECRIMGVCDIYQALT-EDRPYRKGLSHEEAFKILNHMTSD 392 Query: 504 RHL 506 ++ Sbjct: 393 GYI 395 >VCA0681 [T] COG2206 HD-GYP domain Vch Vibrio cholerae Length = 431 Score = 76.6 bits (187), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 46/148 (31%), Positives = 83/148 (56%), Gaps = 13/148 (8%) Query: 379 LGFDMTLPRYRQNMGELHNLGI---------RRGTLTPEDRFAINNHIVQTLVMLKSLPW 429 LG ++ + + G +H++G + G L + I H + L+ + + Sbjct: 271 LGLNVEMQKALYLTGLVHDIGKLHTPEEILHKPGKLNESEYLCIQRHSTDSRYTLQ-MVF 329 Query: 430 PESLKSVPDTAANHHEKMDGTGYPRRLKASELPLQDRVMALADVFEALTAADRPYKPAKT 489 +S+ V + A NHHE++DG+GYPR L+ + + L R++A+ADVF+ALT A RPY+ + + Sbjct: 330 GQSV--VCEWAGNHHERLDGSGYPRGLQGAAIDLPSRIIAIADVFQALTQA-RPYRGSMS 386 Query: 490 LSESLRIMANMCRERHLDTELFRYFLRS 517 L+E + IM + LD+++F +R+ Sbjct: 387 LNEVMNIMRHEVSCGRLDSQVFDVIVRN 414 >TM0037 [T] COG2206 HD-GYP domain Tma Thermotoga maritima Length = 416 Score = 72.8 bits (177), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 38/111 (34%), Positives = 67/111 (60%), Gaps = 5/111 (4%) Query: 401 RRGTLTPEDRFAINNHIVQTLVMLKSLPWPESLKSVPDTAANHHEKMDGTGYPRRLKASE 460 + L+ E+ + H+ + ++L LP+ + +P A HHE++DG GYP RLK E Sbjct: 270 KPAKLSDEEYAIMKKHVYFSYLIL--LPYKDENWFLP--AVRHHERLDGYGYPFRLKGEE 325 Query: 461 LPLQDRVMALADVFEALTAADRPYKPAKTLSESLRIMANMCRERHLDTELF 511 + L+D+++ +ADVF AL +RPY+PA T+ ++L ++ +++ L E F Sbjct: 326 MTLEDKIIQVADVFSALL-EERPYRPANTVEKALSMVREEVKKKKLSQEAF 375 >alr3920 [KT] COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain Nos Nostoc sp. PCC 7120 Length = 414 Score = 72.0 bits (175), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 43/131 (32%), Positives = 70/131 (53%), Gaps = 13/131 (9%) Query: 393 GELHNLG---------IRRGTLTPEDRFAINNHIVQTLVMLKSLPWPESLKSVPDTAANH 443 G LH++G ++ G LTPED + H++ + + L S++ V +H Sbjct: 273 GYLHDIGKVGIPDAVLLKTGKLTPEDWVIMKQHVLIGEKICQPL---RSMQGVVPIIRHH 329 Query: 444 HEKMDGTGYPRRLKASELPLQDRVMALADVFEALTAADRPYKPAKTLSESLRIMANMCRE 503 HE+ DG+GYP LK E+P +V + D+++ALT ++RPYK A T E+L IM + Sbjct: 330 HERWDGSGYPDGLKGDEIPYLAQVFQIIDIYDALT-SERPYKKAYTPEEALCIMLDETET 388 Query: 504 RHLDTELFRYF 514 + +L + F Sbjct: 389 GWRNPKLMQQF 399