BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0011.0002.p (1017 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0010 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1550 0.0 SMc02867 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizob... 1314 0.0 AGl3217 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacteri... 1239 0.0 STM0475 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella ... 1176 0.0 acrB [V] COG0841 Cation/multidrug efflux pump Eco Escherichia co... 1163 0.0 >RSc0010 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1049 Score = 1550 bits (4013), Expect = 0.0, Method: Compositional matrix adjust. Identities = 765/1013 (75%), Positives = 877/1013 (86%), Gaps = 2/1013 (0%) Query: 1 VSQYPNIAPPTIVVTATYPGATAQTLDDSVTSLIEQEMNGADGLQYIESQSQA-NGQVQI 59 ++QYP IAPP+I++TATYPGA+A+TLDD+VTS+IEQEMNGADGL YIES SQA NGQ I Sbjct: 32 IAQYPTIAPPSIIITATYPGASAKTLDDAVTSIIEQEMNGADGLLYIESVSQAGNGQATI 91 Query: 60 TITFSPETNPDLAAVDVQNRLKRVEARLPAAVTQQGVQVTKSRSNFLLFIGLSSTDGKLD 119 T+TF P T+P LA VDVQNRLKRVEARLP++VTQQGVQV K+RSNFLLF L S DGK+D Sbjct: 92 TVTFKPGTDPALAQVDVQNRLKRVEARLPSSVTQQGVQVDKTRSNFLLFATLISKDGKMD 151 Query: 120 PVALGDYLSRNVLNEIKRVPGVGQAQLFGTERAMRIWIDPNKLIGLNLTPADVTAAIQAQ 179 PVALGDY+SRNVLNE+KRVPGVGQA LFGTERAMRIWIDP KL+G LTP DV AI+ Q Sbjct: 152 PVALGDYISRNVLNEVKRVPGVGQAVLFGTERAMRIWIDPAKLVGYKLTPTDVYNAIRNQ 211 Query: 180 NALVAGGTLGALPSPGTQQIAATVVVNGQLTSPEQFGNIILRANANGATVRLRDVARVEV 239 NALV+ GTLG LPS Q IAATVVV GQ+T+ EQFGNI+L + +G+ VR++DVAR+E+ Sbjct: 212 NALVSAGTLGDLPSTSDQPIAATVVVEGQMTTTEQFGNIVLVSKPDGSQVRIKDVARLEL 271 Query: 240 GGQSYDTSGRLDGKPSSFIGVQLSPTANALGTATAVHKKMEELAKYFPTGVKYTIPYDTS 299 GGQ+Y TS R++G+P S IGVQLSPT NALGTA AV K++EL+KYFP GV+Y IPYDTS Sbjct: 272 GGQTYATSARINGQPISAIGVQLSPTGNALGTAKAVKAKLDELSKYFPAGVEYKIPYDTS 331 Query: 300 KFVKISIEEVVKTLIEAIVLVFLVMFLFLQNIRYTIIPTIVVPVALLGTFATLLLFGFSI 359 KFV+ISIEEVVKTL EA+ LVFLVM +FLQNIRYT+IP+IVVP++LLG FAT+ GFSI Sbjct: 332 KFVQISIEEVVKTLFEAMALVFLVMLVFLQNIRYTLIPSIVVPISLLGAFATMNALGFSI 391 Query: 360 NVLTMFGMVLAIGILVDDAIVVVENVERIMSEEGLSPADATRKAMGQISGALIGITLVLI 419 NVLTMFG+VLAIGILVDDAIVVVENVERIMS+EGL P +ATRKAMGQI+GA+IGITLVL+ Sbjct: 392 NVLTMFGLVLAIGILVDDAIVVVENVERIMSQEGLPPREATRKAMGQITGAIIGITLVLM 451 Query: 420 AVFIPMAFFGGAVGAIYRQFSLSMVASMVFSVLMAFTLTPALCATILKPVEKGHHHEKKG 479 AVFIPMAFF G+VGAIYRQFSLSMVAS+ FS LMA TLTPALC+T+LKP+EKG HHEKKG Sbjct: 452 AVFIPMAFFSGSVGAIYRQFSLSMVASIFFSALMALTLTPALCSTLLKPIEKGSHHEKKG 511 Query: 480 FFGWFNRKFNSTASGYQGIIGGMLNKAGRYMIVYVLIVACVGLLYVRLPASFLPNEDQGY 539 FFGWFNR F ST YQ ++ +L K RYM++Y ++A V L++RLP+SFLPNEDQGY Sbjct: 512 FFGWFNRMFTSTTDRYQSLVERVLKKTFRYMVIYGALIAAVVFLFMRLPSSFLPNEDQGY 571 Query: 540 IITNVQLPPGASTSRTTAVVKQIEEYYLKDPAVEHAIAVLGYSFSGNGQNAALVFTPLKD 599 IITN+QLPP AS +RT V+K +E YY + AVE+ +AV G+SFSGNG NAALVFT LKD Sbjct: 572 IITNIQLPPAASANRTLEVIKHVENYYQHEKAVENIVAVQGFSFSGNGPNAALVFTTLKD 631 Query: 600 WSQRDKSQSADAIAGKAFGA-FSQIKDAIVFPLNPPPIPELGNATGFTFRLQDRAGLGHT 658 WS R QSADA+AG+AFGA F I+DAIVFPLNPPPIPELGNATGFTFRLQDR GLGH Sbjct: 632 WSSRGADQSADAVAGRAFGALFGGIRDAIVFPLNPPPIPELGNATGFTFRLQDRGGLGHD 691 Query: 659 ALVQARNQILGMASQSKVLAGVRPEGLEDAPQLQLDIDRDKANALGVPFSTINSVLSTAL 718 AL+ ARNQ+LGMA QSKVL VRP+GLED+PQ Q+DIDR+KANALGV F+ IN+VLSTAL Sbjct: 692 ALMAARNQLLGMAGQSKVLKNVRPDGLEDSPQYQVDIDREKANALGVAFADINNVLSTAL 751 Query: 719 GSSYVNDFPNLGRQQRVIVQADAKRRLQPEDLTNLYARNSSGTMVPFSAFVTAKWINGPV 778 GS+Y NDFPN GRQQRVIVQAD R+QPED+ NLY RN+ G+MVP SAF W+ GPV Sbjct: 752 GSAYANDFPNYGRQQRVIVQADRINRMQPEDIMNLYVRNTQGSMVPMSAFAKGHWVVGPV 811 Query: 779 QLIRYNGYPAMKIAGGAAPGRSTGEAMAEMESFVAKLPPGFGFEWTGQSLEEKTSGNQAP 838 QL+RYNGYP+++I+G AA G STG+AM EME ++LP G GFEWTGQSL+EK+SG+QAP Sbjct: 812 QLVRYNGYPSVRISGDAATGASTGDAMDEMEHLASRLPAGIGFEWTGQSLQEKSSGSQAP 871 Query: 839 ALYALSLIAVFLVLAALYESTSIPLAVMLVVPLGILGALLGVTLRAMPNDVYFKVGMIAV 898 ALYALSL+AVFLVLAALYES SIP AV+LVVPLG+LGALLGVTLR MP+DVYFKVG+IAV Sbjct: 872 ALYALSLLAVFLVLAALYESWSIPAAVILVVPLGVLGALLGVTLRFMPDDVYFKVGLIAV 931 Query: 899 VGLSAKNAILIIEFAKDLQAQGKGLIEATLEAVHLRFRPIIMTSLAFILGVLPLAIASGA 958 VGLSAKNAILIIEFAKDLQAQGKGLIEATLEAVHLRFRPIIMTS AFILGVLPLAIA+GA Sbjct: 932 VGLSAKNAILIIEFAKDLQAQGKGLIEATLEAVHLRFRPIIMTSFAFILGVLPLAIATGA 991 Query: 959 GSASQRAIGTGVMGGMITATVLAVFLVPIFFVVVRKIFKGSERQRKFDAEHSP 1011 SASQRAIGTGVMGGMITATVLAV LVP+FFVVVR+IFKGSERQR+ DA H P Sbjct: 992 SSASQRAIGTGVMGGMITATVLAVVLVPVFFVVVRRIFKGSERQRRLDAAHLP 1044 >SMc02867 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizobium meliloti Length = 1048 Score = 1314 bits (3400), Expect = 0.0, Method: Compositional matrix adjust. Identities = 653/1003 (65%), Positives = 815/1003 (81%), Gaps = 3/1003 (0%) Query: 1 VSQYPNIAPPTIVVTATYPGATAQTLDDSVTSLIEQEMNGADGLQYIESQSQANGQVQIT 60 VSQYP++APP I + YPGA++Q SVT LIE E+NG +GL Y ES + ++G V I Sbjct: 32 VSQYPDVAPPQISINTNYPGASSQDTYQSVTRLIEDELNGVEGLLYFESSTSSSGSVSID 91 Query: 61 ITFSPETNPDLAAVDVQNRLKRVEARLPAAVTQQGVQVTKSRSNFLLFIGLSSTDGKLDP 120 TF P T+P A+VD+QNR++RVE RLP V QQGVQV ++ + FLL I L+STDG +D Sbjct: 92 ATFQPGTDPSQASVDIQNRVQRVEPRLPDPVRQQGVQVDEAGAGFLLIISLTSTDGSMDA 151 Query: 121 VALGDYLSRNVLNEIKRVPGVGQAQLFGTERAMRIWIDPNKLIGLNLTPADVTAAIQAQN 180 + LGDYLSRNVL+EI+RVPGVG+AQLF TER+MR+W+DP+K++GLNLT ADVTAAIQAQN Sbjct: 152 IGLGDYLSRNVLSEIQRVPGVGRAQLFATERSMRVWLDPDKMLGLNLTAADVTAAIQAQN 211 Query: 181 ALVAGGTLGALPSPGTQQIAATVVVNGQLTSPEQFGNIILRANANGATVRLRDVARVEVG 240 A +A G++GA P+P TQQ+ A VV+ GQL+SPE+FG I+LRANA+G+ VRLRDVAR+E+G Sbjct: 212 AQIASGSIGAQPNPITQQVTAPVVIKGQLSSPEEFGAIVLRANADGSAVRLRDVARLEIG 271 Query: 241 GQSYDTSGRLDGKPSSFIGVQLSPTANALGTATAVHKKMEELAKYFPTGVKYTIPYDTSK 300 G+SY S RL+G PS+ I VQLSP+ NA+ T+ A+ +M+ELA++FP G++Y+IPYDTS Sbjct: 272 GESYTFSTRLNGSPSAAIAVQLSPSGNAMSTSAAIKARMDELAEFFPEGLEYSIPYDTSP 331 Query: 301 FVKISIEEVVKTLIEAIVLVFLVMFLFLQNIRYTIIPTIVVPVALLGTFATLLLFGFSIN 360 FV +SIE+V+ TL+EA+ LVFLVMFLFLQN+RYTIIPTIVVPVALLGT A +L GFSIN Sbjct: 332 FVAVSIEKVLHTLVEAVGLVFLVMFLFLQNVRYTIIPTIVVPVALLGTCAVMLAMGFSIN 391 Query: 361 VLTMFGMVLAIGILVDDAIVVVENVERIMSEEGLSPADATRKAMGQISGALIGITLVLIA 420 VLTMFGMVLAIGILVDDAI+VVENVERIMSEEGL+P DATRKAM QI+GA+IGITLVL + Sbjct: 392 VLTMFGMVLAIGILVDDAIIVVENVERIMSEEGLTPKDATRKAMKQITGAVIGITLVLAS 451 Query: 421 VFIPMAFFGGAVGAIYRQFSLSMVASMVFSVLMAFTLTPALCATILKPVEKGHHHEKKGF 480 VFIPMAFF GAVG IYRQFSL+MV S++FS L+A +LTPALCA+ LK V KGHHH K+GF Sbjct: 452 VFIPMAFFPGAVGVIYRQFSLTMVVSILFSALLALSLTPALCASFLKQVPKGHHHAKRGF 511 Query: 481 FGWFNRKFNSTASGYQGIIGGMLNKAGRYMIVYVLIVACVGLLYVRLPASFLPNEDQGYI 540 FGWFNR F+ T+ GY +GG++ + GR+M++Y+ ++A +G +++LP+SFLP+EDQG++ Sbjct: 512 FGWFNRGFDRTSHGYTRAVGGIVRRTGRFMVIYLALLAGLGWAFLQLPSSFLPDEDQGFV 571 Query: 541 ITNVQLPPGASTSRTTAVVKQIEEYYLKDPAVEHAIAVLGYSFSGNGQNAALVFTPLKDW 600 I +QLP A+ +RTT V++Q E + ++ AV+ +A+ G+SF G+GQNA L F LKDW Sbjct: 572 IVMMQLPSEATANRTTEVIEQTETIFGQEKAVDTIVAINGFSFFGSGQNAGLAFVTLKDW 631 Query: 601 SQRDKSQSADAIAGKAFGAFSQIKDAIVFPLNPPPIPELGNATGFTFRLQDRAGLGHTAL 660 S+RD SA +IAG+A A SQIKDAI F L+PP I LG GF+FRLQDRAGLG AL Sbjct: 632 SERDADNSAQSIAGRATMAMSQIKDAISFALSPPAIQGLGTTGGFSFRLQDRAGLGQAAL 691 Query: 661 VQARNQILGMASQSKVLAGVRPEGLEDAPQLQLDIDRDKANALGVPFSTINSVLSTALGS 720 +AR+Q+L +ASQSKVL GVR EG+ DA Q+ ++IDR+KAN GV F+ INS +ST LGS Sbjct: 692 AEARDQLLDLASQSKVLTGVRFEGMPDAAQVSVNIDREKANTFGVTFADINSTISTNLGS 751 Query: 721 SYVNDFPNLGRQQRVIVQADAKRRLQPEDLTNLYARNSSGTMVPFSAFVTAKWINGPVQL 780 SYVNDFPN GR QRV VQAD +R+Q DL NL RNS+G MVP SAF +W+ P Q Sbjct: 752 SYVNDFPNAGRMQRVTVQADETKRMQTADLLNLNVRNSNGGMVPLSAFADVEWVKAPTQT 811 Query: 781 IRYNGYPAMKIAGGAAPGRSTGEAMAEMESFVAKLPPGFGFEWTGQSLEEKTSGNQAPAL 840 + YNGYPA++I+G AAPG S+G+A+AEME VA+LP GFG+EWTGQSL+E SG+QAP L Sbjct: 812 VGYNGYPAVRISGEAAPGYSSGDAIAEMERLVAELPAGFGYEWTGQSLQEIQSGSQAPLL 871 Query: 841 YALSLIAVFLVLAALYESTSIPLAVMLVVPLGILGALLGVTLRAMPNDVYFKVGMIAVVG 900 ALS + VFL LAALYES SIP++V++VVPLG++GA+L VT+R MPNDVYFKVG+IA++G Sbjct: 872 IALSCLLVFLCLAALYESWSIPVSVIMVVPLGVIGAVLAVTMRDMPNDVYFKVGLIAIIG 931 Query: 901 LSAKNAILIIEFAKDLQAQGKGLIEATLEAVHLRFRPIIMTSLAFILGVLPLAIASGAGS 960 LSAKNAILIIEFAK+L+ QGK LI++TLEA HLRFRPI+MTSLAF LGVLPLAIA+GA S Sbjct: 932 LSAKNAILIIEFAKELREQGKSLIDSTLEAAHLRFRPILMTSLAFTLGVLPLAIATGASS 991 Query: 961 ASQRAIGTGVMGGMITATVLAVFLVPIFFVVVRKIFKGSERQR 1003 SQRAIGTGVMGGMI+ATVLA+F VP+FFV V KIF ER R Sbjct: 992 GSQRAIGTGVMGGMISATVLAIFFVPVFFVFVMKIF---ERGR 1031 >AGl3217 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 1044 Score = 1239 bits (3205), Expect = 0.0, Method: Compositional matrix adjust. Identities = 620/982 (63%), Positives = 790/982 (80%), Gaps = 1/982 (0%) Query: 1 VSQYPNIAPPTIVVTATYPGATAQTLDDSVTSLIEQEMNGADGLQYIESQSQANGQVQIT 60 ++QYPN+APP I + YPGA+ + + SVT IE+E+NG GL Y ES S+++G++ I Sbjct: 32 IAQYPNVAPPQISIGTNYPGASPEDIYQSVTRPIEEELNGVPGLIYFESTSESSGRISIN 91 Query: 61 ITFSPETNPDLAAVDVQNRLKRVEARLPAAVTQQGVQVTKSRSNFLLFIGLSSTDGKLDP 120 +TF P TN A V+VQNR+ RVE RLP +VTQQG++V ++ ++FL+ + L+S DG D Sbjct: 92 VTFEPGTNIGEAQVEVQNRIARVEPRLPRSVTQQGLRVEQAGTSFLMMVALTSVDGNTDA 151 Query: 121 VALGDYLSRNVLNEIKRVPGVGQAQLFGTERAMRIWIDPNKLIGLNLTPADVTAAIQAQN 180 + LGDYLSRNVL E++RVPGVG AQLF T+R+MRIW+DP+K++GL+LT DV AIQAQN Sbjct: 152 IGLGDYLSRNVLGELRRVPGVGSAQLFATQRSMRIWMDPDKMLGLSLTSDDVINAIQAQN 211 Query: 181 ALVAGGTLGALPSPGTQQIAATVVVNGQLTSPEQFGNIILRANANGATVRLRDVARVEVG 240 + VA G +GA P+P QQI+ATV V GQLTSPE+FG+I+LRAN +G++VRLRDVARVEVG Sbjct: 212 SQVAAGRIGASPNPVGQQISATVNVQGQLTSPEEFGSIVLRANPDGSSVRLRDVARVEVG 271 Query: 241 GQSYDTSGRLDGKPSSFIGVQLSPTANALGTATAVHKKMEELAKYFPTGVKYTIPYDTSK 300 G+SY+ S RL+GKPS+ IGVQLSPTANA+ T+ V MEEL++YFP G++Y IPYDTS Sbjct: 272 GESYNFSSRLNGKPSAAIGVQLSPTANAMQTSEGVRATMEELSRYFPQGIEYEIPYDTSP 331 Query: 301 FVKISIEEVVKTLIEAIVLVFLVMFLFLQNIRYTIIPTIVVPVALLGTFATLLLFGFSIN 360 FVKISIE+V+ TLIEA++LVF+VMF+FLQNIRYTIIPT+VVPVALLGT A + + GFSIN Sbjct: 332 FVKISIEKVIHTLIEAMILVFVVMFVFLQNIRYTIIPTLVVPVALLGTCAVMYVSGFSIN 391 Query: 361 VLTMFGMVLAIGILVDDAIVVVENVERIMSEEGLSPADATRKAMGQISGALIGITLVLIA 420 VLTMF MVLAIGILVDDAIVVVENVERIM+EE LSP +ATRKAMGQISGA+IGITLVL A Sbjct: 392 VLTMFAMVLAIGILVDDAIVVVENVERIMAEEHLSPKEATRKAMGQISGAIIGITLVLTA 451 Query: 421 VFIPMAFFGGAVGAIYRQFSLSMVASMVFSVLMAFTLTPALCATILKPVEKGHHHEKKGF 480 VF+PMAFF GAVG IY+QFSL+MV S++FS +A +LTPALCA+ LKP++ GHH EKKGF Sbjct: 452 VFVPMAFFPGAVGIIYQQFSLTMVVSILFSGFLALSLTPALCASFLKPIKAGHH-EKKGF 510 Query: 481 FGWFNRKFNSTASGYQGIIGGMLNKAGRYMIVYVLIVACVGLLYVRLPASFLPNEDQGYI 540 FGWFNR F+ + Y +GG++ ++GR+MI+Y ++A +G Y++LP+SFLPNEDQGY+ Sbjct: 511 FGWFNRNFDKASHKYSSSVGGIIKRSGRFMIIYAALLAGLGWAYMQLPSSFLPNEDQGYL 570 Query: 541 ITNVQLPPGASTSRTTAVVKQIEEYYLKDPAVEHAIAVLGYSFSGNGQNAALVFTPLKDW 600 I ++Q P AST RT ++QIE+ ++++PAVE IA+ G+SFSG+GQNA L F LKDW Sbjct: 571 IVDIQAPAEASTERTLQSIQQIEKIFMEEPAVERVIAISGFSFSGSGQNAGLAFATLKDW 630 Query: 601 SQRDKSQSADAIAGKAFGAFSQIKDAIVFPLNPPPIPELGNATGFTFRLQDRAGLGHTAL 660 S+R SA AI+ + G + DA+ F L+PPPI LGN++GFTFRLQDR+G G TAL Sbjct: 631 SERGPEDSAAAISARINGKLWGLPDAMSFALSPPPIQGLGNSSGFTFRLQDRSGAGQTAL 690 Query: 661 VQARNQILGMASQSKVLAGVRPEGLEDAPQLQLDIDRDKANALGVPFSTINSVLSTALGS 720 A Q++ A QS VLAG+R EG+ DA Q+ L IDR+KAN GV FS IN+ +S +GS Sbjct: 691 SAAGAQLMAAARQSPVLAGLRIEGMPDAAQVNLIIDREKANTFGVTFSDINATISANMGS 750 Query: 721 SYVNDFPNLGRQQRVIVQADAKRRLQPEDLTNLYARNSSGTMVPFSAFVTAKWINGPVQL 780 SYVNDFPN GR QRV VQA+ +R++ EDL NL RN++G MVP S+F T +W+ GP Q+ Sbjct: 751 SYVNDFPNAGRMQRVTVQAEQGQRMKTEDLLNLNVRNANGGMVPVSSFATVEWVRGPSQV 810 Query: 781 IRYNGYPAMKIAGGAAPGRSTGEAMAEMESFVAKLPPGFGFEWTGQSLEEKTSGNQAPAL 840 + YNGYPA++++G +APG S+G+A+AEME +LP GFGFEWTGQSL+E SG+QAPAL Sbjct: 811 VGYNGYPAIRVSGQSAPGYSSGDAIAEMERLARELPGGFGFEWTGQSLQEIQSGSQAPAL 870 Query: 841 YALSLIAVFLVLAALYESTSIPLAVMLVVPLGILGALLGVTLRAMPNDVYFKVGMIAVVG 900 LS++ VFL+LAALYES SIPL+VMLVVPLG++G++ V LR MPNDVYF VG++A++G Sbjct: 871 IGLSVLFVFLLLAALYESWSIPLSVMLVVPLGVIGSVAAVMLRGMPNDVYFLVGLVAIIG 930 Query: 901 LSAKNAILIIEFAKDLQAQGKGLIEATLEAVHLRFRPIIMTSLAFILGVLPLAIASGAGS 960 LSAKNAILIIEFAKDL+A+GK +AT+EA HLRFRPI+MTSLAF LGVLP+AIASGA + Sbjct: 931 LSAKNAILIIEFAKDLRAEGKSTYDATVEAAHLRFRPILMTSLAFSLGVLPMAIASGASA 990 Query: 961 ASQRAIGTGVMGGMITATVLAV 982 ASQ AIGTGV+GGMI+AT+LA+ Sbjct: 991 ASQNAIGTGVLGGMISATILAI 1012 >STM0475 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella typhimurium LT2 Length = 1049 Score = 1176 bits (3042), Expect = 0.0, Method: Compositional matrix adjust. Identities = 577/988 (58%), Positives = 741/988 (75%), Gaps = 6/988 (0%) Query: 1 VSQYPNIAPPTIVVTATYPGATAQTLDDSVTSLIEQEMNGADGLQYIESQSQANGQVQIT 60 V+QYP IAPP + ++ATYPGA A+T+ D+VT +IEQ MNG D L Y+ S S + G VQIT Sbjct: 32 VAQYPTIAPPAVTISATYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQIT 91 Query: 61 ITFSPETNPDLAAVDVQNRLKRVEARLPAAVTQQGVQVTKSRSNFLLFIGLSSTDGKLDP 120 +TF T+ D+A V VQN+L+ LP V QQGV V KS S+FL+ +G+ +TDG + Sbjct: 92 LTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQ 151 Query: 121 VALGDYLSRNVLNEIKRVPGVGQAQLFGTERAMRIWIDPNKLIGLNLTPADVTAAIQAQN 180 + DY++ N+ + I R GVG QLFG++ AMRIW++P +L LTP DV AI+AQN Sbjct: 152 EDISDYVAANMKDPISRTSGVGDVQLFGSQYAMRIWMNPTELTKYQLTPVDVINAIKAQN 211 Query: 181 ALVAGGTLGALPSPGTQQIAATVVVNGQLTSPEQFGNIILRANANGATVRLRDVARVEVG 240 A VA G LG P QQ+ A+++ +LTS ++FG I+L+ N +G+ VRLRDVA++E+G Sbjct: 212 AQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTDEFGKILLKVNQDGSQVRLRDVAKIELG 271 Query: 241 GQSYDTSGRLDGKPSSFIGVQLSPTANALGTATAVHKKMEELAKYFPTGVKYTIPYDTSK 300 G++YD + +G+P+S +G++L+ ANAL TATA+ +++++ +FP G+K PYDT+ Sbjct: 272 GENYDVIAKFNGQPASGLGIKLATGANALDTATAIRAELKKMEPFFPPGMKIVYPYDTTP 331 Query: 301 FVKISIEEVVKTLIEAIVLVFLVMFLFLQNIRYTIIPTIVVPVALLGTFATLLLFGFSIN 360 FVKISI EVVKTL+EAI+LVFLVM+LFLQN R T+IPTI VPV LLGTFA L FGFSIN Sbjct: 332 FVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSIN 391 Query: 361 VLTMFGMVLAIGILVDDAIVVVENVERIMSEEGLSPADATRKAMGQISGALIGITLVLIA 420 LTMFGMVLAIG+LVDDAIVVVENVER+M+EEGL P +ATRK+MGQI GAL+GI +VL A Sbjct: 392 TLTMFGMVLAIGLLVDDAIVVVENVERVMTEEGLPPKEATRKSMGQIQGALVGIAMVLSA 451 Query: 421 VFIPMAFFGGAVGAIYRQFSLSMVASMVFSVLMAFTLTPALCATILKPVEKGHHHE-KKG 479 VFIPMAFFGG+ GAIYRQFS+++V++M SVL+A LTPALCAT+LKPV KG H E KKG Sbjct: 452 VFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPVAKGDHGEGKKG 511 Query: 480 FFGWFNRKFNSTASGYQGIIGGMLNKAGRYMIVYVLIVACVGLLYVRLPASFLPNEDQGY 539 FFGWFNR F+ + Y +G +L GRY+++Y++IV + L+VRLP+SFLP+EDQG Sbjct: 512 FFGWFNRLFDKSTHHYTDSVGNILRSTGRYLLLYLIIVVGMAYLFVRLPSSFLPDEDQGV 571 Query: 540 IITNVQLPPGASTSRTTAVVKQIEEYYL-KDPA-VEHAIAVLGYSFSGNGQNAALVFTPL 597 +T VQLP GA+ RT V+ ++ +YYL K+ A VE AV G+ F+G GQN + F L Sbjct: 572 FLTMVQLPAGATQERTQKVLDEVTDYYLNKEKANVESVFAVNGFGFAGRGQNTGIAFVSL 631 Query: 598 KDWSQR-DKSQSADAIAGKAFGAFSQIKDAIVFPLNPPPIPELGNATGFTFRLQDRAGLG 656 KDW+ R + +AI +A AFSQIKDA+VF N P I ELG ATGF F L D+AGLG Sbjct: 632 KDWADRPGEKNKVEAITQRATAAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLG 691 Query: 657 HTALVQARNQILG-MASQSKVLAGVRPEGLEDAPQLQLDIDRDKANALGVPFSTINSVLS 715 H L QARNQ+ G +A +L GVRP GLED PQ ++DID++KA ALGV S IN+ L Sbjct: 692 HEKLTQARNQLFGEVAKYPDLLVGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLG 751 Query: 716 TALGSSYVNDFPNLGRQQRVIVQADAKRRLQPEDLTNLYARNSSGTMVPFSAFVTAKWIN 775 A G SYVNDF + GR ++V V ++AK R+ P+D+ + Y R S G MVPFSAF +++W Sbjct: 752 AAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDINDWYVRGSDGQMVPFSAFSSSRWEY 811 Query: 776 GPVQLIRYNGYPAMKIAGGAAPGRSTGEAMAEMESFVAKLPPGFGFEWTGQSLEEKTSGN 835 G +L RYNG P+M+I G AAPG+STGEAMA ME +KLP G G++WTG S +E+ SGN Sbjct: 812 GSPRLERYNGLPSMEILGQAAPGKSTGEAMAMMEELASKLPSGIGYDWTGMSYQERLSGN 871 Query: 836 QAPALYALSLIAVFLVLAALYESTSIPLAVMLVVPLGILGALLGVTLRAMPNDVYFKVGM 895 QAPALYA+SLI VFL LAALYES SIP +VMLVVPLG++GALL T R + NDVYF+VG+ Sbjct: 872 QAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGL 931 Query: 896 IAVVGLSAKNAILIIEFAKDL-QAQGKGLIEATLEAVHLRFRPIIMTSLAFILGVLPLAI 954 + +GLSAKNAILI+EFAKDL +GKGL+EATLEAV +R RPI+MTSLAF+LGV+PL I Sbjct: 932 LTTIGLSAKNAILIVEFAKDLMDKEGKGLVEATLEAVRMRLRPILMTSLAFMLGVMPLVI 991 Query: 955 ASGAGSASQRAIGTGVMGGMITATVLAV 982 +SGAGS +Q A+GTGV+GGM+TATVLA+ Sbjct: 992 SSGAGSGAQNAVGTGVLGGMVTATVLAI 1019 >acrB [V] COG0841 Cation/multidrug efflux pump Eco Escherichia coli K12 Length = 1049 Score = 1163 bits (3008), Expect = 0.0, Method: Compositional matrix adjust. Identities = 569/988 (57%), Positives = 734/988 (74%), Gaps = 6/988 (0%) Query: 1 VSQYPNIAPPTIVVTATYPGATAQTLDDSVTSLIEQEMNGADGLQYIESQSQANGQVQIT 60 V+QYP IAPP + ++A+YPGA A+T+ D+VT +IEQ MNG D L Y+ S S + G VQIT Sbjct: 32 VAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQIT 91 Query: 61 ITFSPETNPDLAAVDVQNRLKRVEARLPAAVTQQGVQVTKSRSNFLLFIGLSSTDGKLDP 120 +TF T+ D+A V VQN+L+ LP V QQGV V KS S+FL+ +G+ +TDG + Sbjct: 92 LTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQ 151 Query: 121 VALGDYLSRNVLNEIKRVPGVGQAQLFGTERAMRIWIDPNKLIGLNLTPADVTAAIQAQN 180 + DY++ N+ + I R GVG QLFG++ AMRIW++PN+L LTP DV AI+AQN Sbjct: 152 EDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQN 211 Query: 181 ALVAGGTLGALPSPGTQQIAATVVVNGQLTSPEQFGNIILRANANGATVRLRDVARVEVG 240 A VA G LG P QQ+ A+++ +LTS E+FG I+L+ N +G+ V LRDVA++E+G Sbjct: 212 AQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELG 271 Query: 241 GQSYDTSGRLDGKPSSFIGVQLSPTANALGTATAVHKKMEELAKYFPTGVKYTIPYDTSK 300 G++YD +G+P+S +G++L+ ANAL TA A+ ++ ++ +FP+G+K PYDT+ Sbjct: 272 GENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTP 331 Query: 301 FVKISIEEVVKTLIEAIVLVFLVMFLFLQNIRYTIIPTIVVPVALLGTFATLLLFGFSIN 360 FVKISI EVVKTL+EAI+LVFLVM+LFLQN R T+IPTI VPV LLGTFA L FGFSIN Sbjct: 332 FVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSIN 391 Query: 361 VLTMFGMVLAIGILVDDAIVVVENVERIMSEEGLSPADATRKAMGQISGALIGITLVLIA 420 LTMFGMVLAIG+LVDDAIVVVENVER+M+EEGL P +ATRK+MGQI GAL+GI +VL A Sbjct: 392 TLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSA 451 Query: 421 VFIPMAFFGGAVGAIYRQFSLSMVASMVFSVLMAFTLTPALCATILKPVEKGHHHE-KKG 479 VF+PMAFFGG+ GAIYRQFS+++V++M SVL+A LTPALCAT+LKP+ KG H E KKG Sbjct: 452 VFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKG 511 Query: 480 FFGWFNRKFNSTASGYQGIIGGMLNKAGRYMIVYVLIVACVGLLYVRLPASFLPNEDQGY 539 FFGWFNR F + Y +GG+L GRY+++Y++IV + L+VRLP+SFLP+EDQG Sbjct: 512 FFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRLPSSFLPDEDQGV 571 Query: 540 IITNVQLPPGASTSRTTAVVKQIEEYYLKDPA--VEHAIAVLGYSFSGNGQNAALVFTPL 597 +T VQLP GA+ RT V+ ++ YYL VE AV G+ F+G GQN + F L Sbjct: 572 FMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSL 631 Query: 598 KDWSQR-DKSQSADAIAGKAFGAFSQIKDAIVFPLNPPPIPELGNATGFTFRLQDRAGLG 656 KDW+ R + +AI +A AFSQIKDA+VF N P I ELG ATGF F L D+AGLG Sbjct: 632 KDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLG 691 Query: 657 HTALVQARNQILGMASQS-KVLAGVRPEGLEDAPQLQLDIDRDKANALGVPFSTINSVLS 715 H L QARNQ+L A++ +L VRP GLED PQ ++DID++KA ALGV + IN+ L Sbjct: 692 HEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLG 751 Query: 716 TALGSSYVNDFPNLGRQQRVIVQADAKRRLQPEDLTNLYARNSSGTMVPFSAFVTAKWIN 775 A G SYVNDF + GR ++V V ++AK R+ P+D+ + Y R + G MVPFSAF +++W Sbjct: 752 AAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEY 811 Query: 776 GPVQLIRYNGYPAMKIAGGAAPGRSTGEAMAEMESFVAKLPPGFGFEWTGQSLEEKTSGN 835 G +L RYNG P+M+I G AAPG+STGEAM ME +KLP G G++WTG S +E+ SGN Sbjct: 812 GSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSYQERLSGN 871 Query: 836 QAPALYALSLIAVFLVLAALYESTSIPLAVMLVVPLGILGALLGVTLRAMPNDVYFKVGM 895 QAP+LYA+SLI VFL LAALYES SIP +VMLVVPLG++GALL T R + NDVYF+VG+ Sbjct: 872 QAPSLYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGL 931 Query: 896 IAVVGLSAKNAILIIEFAKDL-QAQGKGLIEATLEAVHLRFRPIIMTSLAFILGVLPLAI 954 + +GLSAKNAILI+EFAKDL +GKGLIEATL+AV +R RPI+MTSLAFILGV+PL I Sbjct: 932 LTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAVRMRLRPILMTSLAFILGVMPLVI 991 Query: 955 ASGAGSASQRAIGTGVMGGMITATVLAV 982 ++GAGS +Q A+GTGVMGGM+TATVLA+ Sbjct: 992 STGAGSGAQNAVGTGVMGGMVTATVLAI 1019