BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0008.0520.p (408 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value STM2372 [GEPR] COG0477 Permeases of the major facilitator superf... 302 1e-81 ECs3206 [GEPR] COG0477 Permeases of the major facilitator superf... 297 3e-80 Z3585 [GEPR] COG0477 Permeases of the major facilitator superfam... 295 2e-79 yfcJ [GEPR] COG0477 Permeases of the major facilitator superfami... 294 3e-79 PA1993 [GEPR] COG0477 Permeases of the major facilitator superfa... 273 4e-73 >STM2372 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 392 Score = 302 bits (773), Expect = 1e-81, Method: Compositional matrix adjust. Identities = 168/372 (45%), Positives = 237/372 (63%) Query: 24 FKLAPITLAVFIAFLTIGLQLPVLPLHLKDALGMNATVVGVVVGAQFAAALLSRAWAGNF 83 F L I AVF+ ++T+GL LPV+PL + LG + T+VG+ VG QF A +L+R +AG Sbjct: 15 FSLFRIAFAVFLTYMTVGLPLPVIPLFVHHELGYSNTMVGIAVGIQFFATVLTRGYAGRL 74 Query: 84 ADLRGAKRAVMAGFVTAALSGLVYLASLALLGRPDWSVAVLLLGRVVLALGESLMVTGAM 143 AD GAKR+ + G + L+G +L + L A+L++GR++L GES ++TG + Sbjct: 75 ADQYGAKRSALQGMLACGLAGAAWLLAALLPVSAPVKFALLIVGRLILGFGESQLLTGTL 134 Query: 144 SWGIGLVGPQHGGKVMAWLGIALYAAFGAGAPLGVAINQVYGFAGISLASVGLPLAALLL 203 +WG+GLVGP GKVM+W G+A+Y A AGAPLG+ I+ +GFA ++ ++ LPL A Sbjct: 135 TWGLGLVGPTRSGKVMSWNGMAIYGALAAGAPLGLLIHSHFGFAALAGTTMVLPLLAWAF 194 Query: 204 IAPLRAIAPSASRRTPFYQVLGAVWRPGLGLAFSSVGFGVITAFIALLFAARAWGNAALA 263 +R + R + V+G +W+PGLGLA VGF VI FI+L F + W A Sbjct: 195 NGTVRKVPAYTGERPSLWSVVGLIWKPGLGLALQGVGFAVIGTFISLYFVSNGWTMAGFT 254 Query: 264 FSAFGAAFILARLLFAHLPDKLGGARVALVCVLIEAAGQLLIWQADAAHWAYLGAALTGF 323 +AFG AF+L R+LF +PD+ GG +VA+V +L+E AG LL+W A A A +GAALTG Sbjct: 255 LTAFGGAFVLMRILFGWMPDRFGGVKVAVVSLLVETAGLLLLWLAPTAWIALVGAALTGA 314 Query: 324 GYSLAFPGFGVEAMRRAPPQTRGLAMGAYVAFLDLSLGITSPLAGALAQAWGVEAVYLLG 383 G SL FP GVE ++R P Q RG A+G Y AF D+S G+T PLAG LA ++G +V+L G Sbjct: 315 GCSLIFPALGVEVVKRVPAQVRGTALGGYAAFQDISYGVTGPLAGMLATSYGYPSVFLAG 374 Query: 384 AVMVALAALVAL 395 A+ + LV + Sbjct: 375 AISAVVGILVTI 386 >ECs3206 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 392 Score = 297 bits (760), Expect = 3e-80, Method: Compositional matrix adjust. Identities = 168/372 (45%), Positives = 241/372 (64%) Query: 24 FKLAPITLAVFIAFLTIGLQLPVLPLHLKDALGMNATVVGVVVGAQFAAALLSRAWAGNF 83 F L I AVF+ ++T+GL LPV+PL + LG T+VG+ VG QF A +L+R +AG Sbjct: 15 FSLFRIAFAVFLTYMTVGLPLPVIPLFVHHDLGYGNTMVGIAVGIQFLATVLTRGYAGRL 74 Query: 84 ADLRGAKRAVMAGFVTAALSGLVYLASLALLGRPDWSVAVLLLGRVVLALGESLMVTGAM 143 AD GAKR+ + G + L+G L + L + A+L++GR++L GES ++TGA+ Sbjct: 75 ADQYGAKRSALQGMLACGLAGGALLLAAILPVSAPFKFALLVIGRLILGFGESQLLTGAL 134 Query: 144 SWGIGLVGPQHGGKVMAWLGIALYAAFGAGAPLGVAINQVYGFAGISLASVGLPLAALLL 203 +WG+G+VGP+H GKVM+W G+A+Y A GAPLG+ I+ YGFA ++L ++ LPL A Sbjct: 135 TWGLGIVGPKHSGKVMSWNGMAIYGALAVGAPLGLLIHSHYGFAALALTTMALPLLAWAC 194 Query: 204 IAPLRAIAPSASRRTPFYQVLGAVWRPGLGLAFSSVGFGVITAFIALLFAARAWGNAALA 263 +R + A R + V+G +W+PGLGLA VGF VI F++L FA++ W A Sbjct: 195 NGTVRKVPALAGERPSLWSVVGLIWKPGLGLALQGVGFAVIGTFVSLYFASKGWAMAGFT 254 Query: 264 FSAFGAAFILARLLFAHLPDKLGGARVALVCVLIEAAGQLLIWQADAAHWAYLGAALTGF 323 +AFG AF++ R++F +PD+ GG +VA+V +L+E G LL+WQA A A GAALTG Sbjct: 255 LTAFGGAFVVMRVMFGWMPDRFGGVKVAIVSLLVETVGLLLLWQAPGAWVALAGAALTGA 314 Query: 324 GYSLAFPGFGVEAMRRAPPQTRGLAMGAYVAFLDLSLGITSPLAGALAQAWGVEAVYLLG 383 G SL FP GVE ++R P Q RG A+G Y AF D++LG++ PLAG LA +G +V+L G Sbjct: 315 GCSLIFPALGVEVVKRVPSQVRGTALGGYAAFQDIALGVSGPLAGMLATTFGYSSVFLAG 374 Query: 384 AVMVALAALVAL 395 A+ L +V + Sbjct: 375 AISAVLGIIVTI 386 >Z3585 [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 392 Score = 295 bits (754), Expect = 2e-79, Method: Compositional matrix adjust. Identities = 167/372 (44%), Positives = 240/372 (64%) Query: 24 FKLAPITLAVFIAFLTIGLQLPVLPLHLKDALGMNATVVGVVVGAQFAAALLSRAWAGNF 83 F L I AVF+ ++T+ L LPV+PL + LG T+VG+ VG QF A +L+R +AG Sbjct: 15 FSLFRIAFAVFLTYMTVXLPLPVIPLFVHHDLGYGNTMVGIAVGIQFLATVLTRGYAGRL 74 Query: 84 ADLRGAKRAVMAGFVTAALSGLVYLASLALLGRPDWSVAVLLLGRVVLALGESLMVTGAM 143 AD GAKR+ + G + L+G L + L + A+L++GR++L GES ++TGA+ Sbjct: 75 ADQYGAKRSALQGMLACGLAGGALLLAAILPVSAPFKFALLVIGRLILGFGESQLLTGAL 134 Query: 144 SWGIGLVGPQHGGKVMAWLGIALYAAFGAGAPLGVAINQVYGFAGISLASVGLPLAALLL 203 +WG+G+VGP+H GKVM+W G+A+Y A GAPLG+ I+ YGFA ++L ++ LPL A Sbjct: 135 TWGLGIVGPKHSGKVMSWNGMAIYGALAVGAPLGLLIHSHYGFAALALTTMALPLLAWAC 194 Query: 204 IAPLRAIAPSASRRTPFYQVLGAVWRPGLGLAFSSVGFGVITAFIALLFAARAWGNAALA 263 +R + A R + V+G +W+PGLGLA VGF VI F++L FA++ W A Sbjct: 195 NGTVRKVPALAGERPSLWSVVGLIWKPGLGLALQGVGFAVIGTFVSLYFASKGWAMAGFT 254 Query: 264 FSAFGAAFILARLLFAHLPDKLGGARVALVCVLIEAAGQLLIWQADAAHWAYLGAALTGF 323 +AFG AF++ R++F +PD+ GG +VA+V +L+E G LL+WQA A A GAALTG Sbjct: 255 LTAFGGAFVVMRVMFGWMPDRFGGVKVAIVSLLVETVGLLLLWQAPGAWVALAGAALTGA 314 Query: 324 GYSLAFPGFGVEAMRRAPPQTRGLAMGAYVAFLDLSLGITSPLAGALAQAWGVEAVYLLG 383 G SL FP GVE ++R P Q RG A+G Y AF D++LG++ PLAG LA +G +V+L G Sbjct: 315 GCSLIFPALGVEVVKRVPSQVRGTALGGYAAFQDIALGVSGPLAGMLATTFGYSSVFLAG 374 Query: 384 AVMVALAALVAL 395 A+ L +V + Sbjct: 375 AISAVLGIIVTI 386 >yfcJ [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 392 Score = 294 bits (752), Expect = 3e-79, Method: Compositional matrix adjust. Identities = 166/372 (44%), Positives = 241/372 (64%) Query: 24 FKLAPITLAVFIAFLTIGLQLPVLPLHLKDALGMNATVVGVVVGAQFAAALLSRAWAGNF 83 F L I AVF+ ++T+GL LPV+PL + LG T+VG+ VG QF A +L+R +AG Sbjct: 15 FSLFRIAFAVFLTYMTVGLPLPVIPLFVHHELGYGNTMVGIAVGIQFLATVLTRGYAGRL 74 Query: 84 ADLRGAKRAVMAGFVTAALSGLVYLASLALLGRPDWSVAVLLLGRVVLALGESLMVTGAM 143 AD GAKR+ + G + L+G L + L + A+L++GR++L GES ++TGA+ Sbjct: 75 ADQYGAKRSALQGMLACGLAGGALLLAAILPVSAPFKFALLVVGRLILGFGESQLLTGAL 134 Query: 144 SWGIGLVGPQHGGKVMAWLGIALYAAFGAGAPLGVAINQVYGFAGISLASVGLPLAALLL 203 +WG+G+VGP+H GKVM+W G+A+Y A GAPLG+ I+ YGFA +++ ++ LP+ A Sbjct: 135 TWGLGIVGPKHSGKVMSWNGMAIYGALAVGAPLGLLIHSHYGFAALAITTMVLPVLAWAC 194 Query: 204 IAPLRAIAPSASRRTPFYQVLGAVWRPGLGLAFSSVGFGVITAFIALLFAARAWGNAALA 263 +R + A R + V+G +W+PGLGLA VGF VI F++L FA++ W A Sbjct: 195 NGTVRKVPALAGERPSLWSVVGLIWKPGLGLALQGVGFAVIGTFVSLYFASKGWAMAGFT 254 Query: 264 FSAFGAAFILARLLFAHLPDKLGGARVALVCVLIEAAGQLLIWQADAAHWAYLGAALTGF 323 +AFG AF++ R++F +PD+ GG +VA+V +L+E G LL+WQA A A GAALTG Sbjct: 255 LTAFGGAFVVMRVMFGWMPDRFGGVKVAIVSLLVETVGLLLLWQAPGAWVALAGAALTGA 314 Query: 324 GYSLAFPGFGVEAMRRAPPQTRGLAMGAYVAFLDLSLGITSPLAGALAQAWGVEAVYLLG 383 G SL FP GVE ++R P Q RG A+G Y AF D++LG++ PLAG LA +G +V+L G Sbjct: 315 GCSLIFPALGVEVVKRVPSQVRGTALGGYAAFQDIALGVSGPLAGMLATTFGYSSVFLAG 374 Query: 384 AVMVALAALVAL 395 A+ L +V + Sbjct: 375 AISAVLGIIVTI 386 >PA1993 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 402 Score = 273 bits (699), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 176/388 (45%), Positives = 236/388 (60%), Gaps = 12/388 (3%) Query: 22 VFFKLAPITLAVFIAFLTIGLQLPVLPLHLKDALGMNATVVGVVVGAQFAAALLSRAWAG 81 V ++ + + FI +LTIG+ L VLP ++ D LG + + G+V+ Q+ A LL+R +AG Sbjct: 19 VTLQIVSVVMFTFIGYLTIGIPLAVLPGYVHDDLGYGSVLAGLVISLQYLATLLARPYAG 78 Query: 82 NFADLRGAKRAVMAGFVTAALSGLVYLASLALLGRPDWSVAVLLLGRVVLALGESLMVTG 141 D G KRAV+ G +A SGL L S+A+ G P S+A LL+GR+VL ESL+ + Sbjct: 79 RVIDGLGPKRAVLYGMAGSAASGLFMLLSVAIQGWPALSLASLLVGRLVLGAAESLVGSA 138 Query: 142 AMSWGIGLVGPQHGGKVMAWLGIALYAAFGAGAPLGVAINQVYGFAGIS-----LASVGL 196 A+ WGIG VG H KV++W GIA Y A GAPLGV + Q G + L ++G Sbjct: 139 AIGWGIGRVGAPHTAKVISWNGIASYGAIALGAPLGVLLVQWLGLWSMGASIVLLGALGF 198 Query: 197 PLAALLLIAPLRAIAPSASRRTPFYQVLGAVWRPGLGLAFSSVGFGVITAFIALLFAARA 256 LA L APL R PF+ VLG V G+GLA ++GFG I FI L +A+R Sbjct: 199 ALAWPKLPAPL-----VHGERLPFHHVLGRVTPHGMGLALGAIGFGTIATFITLYYASRG 253 Query: 257 WGNAALAFSAFGAAFILARLLFAHLPDKLGGARVALVCVLIEAAGQLLIWQADAAHWAYL 316 W NA L SAFG FI ARLLFA+ ++LGG RVA++C+ +E+ G LL+W A Sbjct: 254 WANAVLCLSAFGGCFIGARLLFANSINRLGGFRVAIICLGVESLGLLLLWSAPNPWVGLA 313 Query: 317 GAALTGFGYSLAFPGFGVEAMRRAPPQTRGLAMGAYVAFLDLSLGITSPLAGALAQAWGV 376 GAALTGFG+SL FP FGVEA+ P RG A+GAY F+DLSLGIT PL G +A +G Sbjct: 314 GAALTGFGFSLVFPAFGVEAVNLVPASNRGAALGAYSLFVDLSLGITGPLVGFVANLFGF 373 Query: 377 EAVYLLGAVMVALAAL-VALGLMRTSPQ 403 +++L A + +L L +A+ L R S + Sbjct: 374 RSMFLF-ACLASLGGLALAVALHRRSRR 400