BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0008.0363.p (496 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2805 [F] COG0209 Ribonucleotide reductase, alpha subunit Rso ... 817 0.0 PA1156 [F] COG0209 Ribonucleotide reductase, alpha subunit Pae P... 672 0.0 CT827 [F] COG0209 Ribonucleotide reductase, alpha subunit Ctr Ch... 545 e-155 CPn0984 [F] COG0209 Ribonucleotide reductase, alpha subunit Cpn ... 531 e-150 VNG2384G [F] COG0209 Ribonucleotide reductase, alpha subunit Hbs... 509 e-144 >RSc2805 [F] COG0209 Ribonucleotide reductase, alpha subunit Rso Ralstonia solanacearum Length = 987 Score = 817 bits (2110), Expect = 0.0, Method: Compositional matrix adjust. Identities = 398/501 (79%), Positives = 428/501 (85%), Gaps = 12/501 (2%) Query: 1 MEKGEWTLFSPSDTPDLHDKFGRAFEEAYTAYEAKAARGELKLFKKVQANDLWRKMLSML 60 ME GEWTLFSPS PDLHDK G+AFE AY YE K ARGE+KLFKK+ A LWRKML ML Sbjct: 494 MEGGEWTLFSPSTCPDLHDKVGKAFEAAYLGYEDKVARGEIKLFKKMPALQLWRKMLGML 553 Query: 61 FETGHPWITFKDPCNIRSPQQHVGVVHSSNLCTEITLNTNDSEIAVCNLGSVNLPAHLVN 120 FETGHPWITFKDPCNIRSPQQHVGVVHSSNLCTEITLNTNDSEIAVCNLGSVNL AH+V Sbjct: 554 FETGHPWITFKDPCNIRSPQQHVGVVHSSNLCTEITLNTNDSEIAVCNLGSVNLVAHVVK 613 Query: 121 GE-----LDHAKLQKTIRTAMRMLDNVIDINYYAVKKARDSNLRHRPVGMGIMGFQDCLH 175 LDH KL+KT+RTAMRMLDNVIDINYYAVKKARDSNLRHRPVG+GIMGFQD LH Sbjct: 614 QADGSYALDHDKLKKTVRTAMRMLDNVIDINYYAVKKARDSNLRHRPVGLGIMGFQDALH 673 Query: 176 IKRVPYASMDAVEFADRSMEAVCYYAYMASTELAEERGRYASYRGSLWDRGILPQDSLKL 235 + R+PYA+ AV+FAD SMEAVCYYAY ASTELAEERGRY++Y+GSLWDRG+LPQDSLKL Sbjct: 674 VLRIPYATDAAVQFADTSMEAVCYYAYWASTELAEERGRYSTYKGSLWDRGVLPQDSLKL 733 Query: 236 LAQERGGYLETDSTETLDWAALRARIAEHGMRNSNCVAIAPTATISNIIGVSACIEPTYQ 295 LAQERGGYLE D + T+DW LR RI +HGMRNSNCVAIAPTATISNIIGVSACIEPTYQ Sbjct: 734 LAQERGGYLEADLSSTMDWDGLRERIQQHGMRNSNCVAIAPTATISNIIGVSACIEPTYQ 793 Query: 296 NLYVKSNLSGEFTEINEYLVRDLKARGLWDEVMVADLKYFDGSLAKIDRIPQDLRDIYAT 355 NLYVKSNLSGEFT +N+YLVRDLKARGLWDEVMVADLKYFDGSLA+IDRIPQDLRD+YAT Sbjct: 794 NLYVKSNLSGEFTVVNDYLVRDLKARGLWDEVMVADLKYFDGSLARIDRIPQDLRDLYAT 853 Query: 356 AFEVDPSWLVEAASRRQKWIDQAQSLNIYMAGASGKRLDETYKLAWLRGLKTTYYLRTIG 415 AFEV+P WLVEAASRRQKWIDQAQSLNIYMAGASGK LD+TYKLAWLRGLKTTYYLRTIG Sbjct: 854 AFEVEPQWLVEAASRRQKWIDQAQSLNIYMAGASGKMLDDTYKLAWLRGLKTTYYLRTIG 913 Query: 416 ATHTEKSTSRAGALNAVAVDGGAGAMASASGTAVPAAPIASAATASAAYVMPNPGAAIEA 475 ATH EKST G LNAV+ G +A+G A A A A+ A MP +A Sbjct: 914 ATHVEKSTVSRGTLNAVS-SGSDAGSVAAAGAAPVAPASALDTVAATAPAMP------DA 966 Query: 476 DGPVCTMRPGDAGFEECEACQ 496 +G VCTMRPGD GFEECEACQ Sbjct: 967 EGAVCTMRPGDPGFEECEACQ 987 >PA1156 [F] COG0209 Ribonucleotide reductase, alpha subunit Pae Pseudomonas aeruginosa Length = 963 Score = 672 bits (1735), Expect = 0.0, Method: Compositional matrix adjust. Identities = 314/440 (71%), Positives = 371/440 (84%), Gaps = 2/440 (0%) Query: 1 MEKGEWTLFSPSDTPDLHDKFGRAFEEAYTAYEAKAARGELKLFKKVQANDLWRKMLSML 60 + G WTLFSPSD PDLHD +G+AFEE Y YEA A+ G+LKL K VQA DLWRKMLSML Sbjct: 496 FDDGSWTLFSPSDVPDLHDLYGKAFEERYEYYEALASYGKLKLHKVVQAKDLWRKMLSML 555 Query: 61 FETGHPWITFKDPCNIRSPQQHVGVVHSSNLCTEITLNTNDSEIAVCNLGSVNLPAHLVN 120 FETGHPW+TFKDPCN+RSPQQHVGVVHSSNLCTEITLNTN EIAVCNLGS+NL H+V+ Sbjct: 556 FETGHPWLTFKDPCNLRSPQQHVGVVHSSNLCTEITLNTNKDEIAVCNLGSINLVNHIVD 615 Query: 121 GELDHAKLQKTIRTAMRMLDNVIDINYYAVKKARDSNLRHRPVGMGIMGFQDCLHIKRVP 180 G+LD AKL+KT++TA+RMLDNVIDINYY+V +A++SN +HRPVG+GIMGFQD L+++ +P Sbjct: 616 GKLDTAKLEKTVKTAVRMLDNVIDINYYSVPQAQNSNFKHRPVGLGIMGFQDALYLQHIP 675 Query: 181 YASMDAVEFADRSMEAVCYYAYMASTELAEERGRYASYRGSLWDRGILPQDSLKLLAQER 240 Y S A+ FAD+SMEA+ YYA AS +LA+ERG Y +++GSLW +GILP DS K L +ER Sbjct: 676 YGSDAAIAFADQSMEAISYYAIQASCDLADERGAYQTFQGSLWSQGILPIDSEKKLIEER 735 Query: 241 GG-YLETDSTETLDWAALRARIAEHGMRNSNCVAIAPTATISNIIGVSACIEPTYQNLYV 299 G Y+E D +ETLDWA LR R+ + G+RNSN +AIAPTATI+NI GVS IEPTYQNLYV Sbjct: 736 GAKYIEVDLSETLDWAPLRERV-QKGIRNSNIMAIAPTATIANITGVSQSIEPTYQNLYV 794 Query: 300 KSNLSGEFTEINEYLVRDLKARGLWDEVMVADLKYFDGSLAKIDRIPQDLRDIYATAFEV 359 KSNLSGEFT IN YLVRDLKARGLWD VMV DLKY+DGS+ +I+RIPQDL+D+YATAFEV Sbjct: 795 KSNLSGEFTVINPYLVRDLKARGLWDPVMVNDLKYYDGSVQQIERIPQDLKDLYATAFEV 854 Query: 360 DPSWLVEAASRRQKWIDQAQSLNIYMAGASGKRLDETYKLAWLRGLKTTYYLRTIGATHT 419 + W+VEAASRRQKWIDQAQSLN+Y+AGASGK+LD TY++AW RGLKTTYYLR + AT T Sbjct: 855 ETRWIVEAASRRQKWIDQAQSLNLYIAGASGKKLDVTYRMAWFRGLKTTYYLRALAATST 914 Query: 420 EKSTSRAGALNAVAVDGGAG 439 EKST G LNAV+ G G Sbjct: 915 EKSTINTGKLNAVSAGGNDG 934 >CT827 [F] COG0209 Ribonucleotide reductase, alpha subunit Ctr Chlamydia trachomatis Length = 1047 Score = 545 bits (1404), Expect = e-155, Method: Compositional matrix adjust. Identities = 270/496 (54%), Positives = 336/496 (67%), Gaps = 31/496 (6%) Query: 2 EKGEWTLFSPSDTPDLHDKFGRAFEEAYTAYEAKAARGELKLFKKVQANDLWRKMLSMLF 61 +KG WTLFSP D P LHD +G FE Y YE K GE++LFKKV+A DLWRKMLSMLF Sbjct: 582 QKGTWTLFSPDDVPGLHDAYGEEFERLYEEYERKVDTGEIRLFKKVEAEDLWRKMLSMLF 641 Query: 62 ETGHPWITFKDPCNIRSPQQHVGVVHSSNLCTEITLNTNDSEIAVCNLGSVNLPAHLVNG 121 ETGHPW+TFKDP NIRS Q H GVV SNLCTEI LN +++E AVCNLGS+NL H+V Sbjct: 642 ETGHPWMTFKDPSNIRSAQDHKGVVRCSNLCTEILLNCSETETAVCNLGSINLVQHIVGD 701 Query: 122 ELDHAKLQKTIRTAMRMLDNVIDINYYAVKKARDSNLRHRPVGMGIMGFQDCLHIKRVPY 181 LD KL +TI A+RMLDNVIDIN+Y K+A+++N HR +G+G+MGFQD L+ + Y Sbjct: 702 GLDEEKLSETISIAVRMLDNVIDINFYPTKEAKEANFAHRAIGLGVMGFQDALYKLDISY 761 Query: 182 ASMDAVEFADRSMEAVCYYAYMASTELAEERGRYASYRGSLWDRGILPQDSLKLLAQERG 241 AS +AVEFAD S E + YYA AS LA+ERG Y+SY+GS WDRG+LP D+++LLA RG Sbjct: 762 ASQEAVEFADYSSELISYYAIQASCLLAKERGTYSSYKGSKWDRGLLPIDTIQLLANYRG 821 Query: 242 -GYLETDSTETLDWAALRARIAEHGMRNSNCVAIAPTATISNIIGVSACIEPTYQNLYVK 300 L+ D++ DW +R+ + EHGMR+ +AIAPTATISNIIGV+ IEPTY++L+VK Sbjct: 822 EANLQMDTSSRKDWEPIRSLVKEHGMRHCQLMAIAPTATISNIIGVTQSIEPTYKHLFVK 881 Query: 301 SNLSGEFTEINEYLVRDLKARGLWDEVMVADLKYFDGSLAKIDRIPQDLRDIYATAFEVD 360 SNLSGEFT N YL+ LK G+WD M+ DLKYFDGSL +I+RIP L+ I+ TAFE++ Sbjct: 882 SNLSGEFTIPNVYLIEKLKKLGIWDADMLDDLKYFDGSLLEIERIPDHLKHIFLTAFEIE 941 Query: 361 PSWLVEAASRRQKWIDQAQSLNIYMAGASGKRLDETYKLAWLRGLKTTYYLRTIGATHTE 420 P W++E ASRRQKWID QSLN+Y+A GK+L Y AW +GLKTTYYLR+ AT E Sbjct: 942 PEWIIECASRRQKWIDMGQSLNLYLAQPDGKKLSNMYLTAWKKGLKTTYYLRSSSATTVE 1001 Query: 421 KSTSRAGALNAVAVDGGAGAMASASGTAVPAAPIASAATASAAYVMPNPGAAIEADGPVC 480 KS VD + +ASA ++ A PVC Sbjct: 1002 KS----------FVDINKRGIQPR---------WMKNKSASAGIIVERAKKA-----PVC 1037 Query: 481 TMRPGDAGFEECEACQ 496 ++ G CEACQ Sbjct: 1038 SLEEG------CEACQ 1047 >CPn0984 [F] COG0209 Ribonucleotide reductase, alpha subunit Cpn Chlamydophila pneumoniae CWL029 Length = 1044 Score = 531 bits (1368), Expect = e-150, Method: Compositional matrix adjust. Identities = 262/496 (52%), Positives = 333/496 (67%), Gaps = 32/496 (6%) Query: 2 EKGEWTLFSPSDTPDLHDKFGRAFEEAYTAYEAKAARGELKLFKKVQANDLWRKMLSMLF 61 +KG WTLFSP D P LH+ +G FE+ Y YE K GE++L+KKV+A LWRKMLSML+ Sbjct: 580 KKGMWTLFSPDDVPGLHEAYGLEFEKLYEEYERKVESGEIRLYKKVEAEVLWRKMLSMLY 639 Query: 62 ETGHPWITFKDPCNIRSPQQHVGVVHSSNLCTEITLNTNDSEIAVCNLGSVNLPAHLVNG 121 ETGHPWITFKDP NIRS Q HVGVV SNLCTEI LN ++SE AVCNLGS+NL H+ N Sbjct: 640 ETGHPWITFKDPSNIRSNQDHVGVVRCSNLCTEILLNCSESETAVCNLGSINLVEHIRND 699 Query: 122 ELDHAKLQKTIRTAMRMLDNVIDINYYAVKKARDSNLRHRPVGMGIMGFQDCLHIKRVPY 181 +LD KL++TI A+R+LDNVID+N+Y +A+ +NL HR VG+G+MGFQD L+ + Y Sbjct: 700 KLDEEKLKETISIAIRILDNVIDLNFYPTPEAKQANLTHRAVGLGVMGFQDVLYELNISY 759 Query: 182 ASMDAVEFADRSMEAVCYYAYMASTELAEERGRYASYRGSLWDRGILPQDSLKLLAQERG 241 AS +AVEF+D E + YYA +AS+ LA+ERG YASY GS WDRG LP D+++LL + RG Sbjct: 760 ASQEAVEFSDECSEIIAYYAILASSLLAKERGTYASYSGSKWDRGYLPLDTIELLKETRG 819 Query: 242 GY-LETDSTETLDWAALRARIAEHGMRNSNCVAIAPTATISNIIGVSACIEPTYQNLYVK 300 + + D++ DW +R I ++GMRNS +AIAPTATISNIIGV+ IEP Y++L+VK Sbjct: 820 EHNVLVDTSSKKDWTPVRDTIQKYGMRNSQVMAIAPTATISNIIGVTQSIEPMYKHLFVK 879 Query: 301 SNLSGEFTEINEYLVRDLKARGLWDEVMVADLKYFDGSLAKIDRIPQDLRDIYATAFEVD 360 SNLSGEFT N YL++ LK GLWD M+ DLKYFDGSL +I+RIP L+ ++ TAFE++ Sbjct: 880 SNLSGEFTIPNTYLIKKLKELGLWDAEMLDDLKYFDGSLLEIERIPNHLKKLFLTAFEIE 939 Query: 361 PSWLVEAASRRQKWIDQAQSLNIYMAGASGKRLDETYKLAWLRGLKTTYYLRTIGATHTE 420 P W++E SRRQKWID SLN+Y+A GK+L Y AW +GLKTTYYLR+ AT E Sbjct: 940 PEWIIECTSRRQKWIDMGVSLNLYLAEPDGKKLSNMYLTAWKKGLKTTYYLRSQAATSVE 999 Query: 421 KSTSRAGALNAVAVDGGAGAMASASGTAVPAAPIASAATASAAYVMPNPGAAIEADGPVC 480 KS +N + SAS + V PVC Sbjct: 1000 KSFI---DINKRGIQPRWMKNKSASTSIVVERKTT----------------------PVC 1034 Query: 481 TMRPGDAGFEECEACQ 496 +M G CE+CQ Sbjct: 1035 SMEEG------CESCQ 1044 >VNG2384G [F] COG0209 Ribonucleotide reductase, alpha subunit Hbs Halobacterium sp. NRC-1 Length = 804 Score = 509 bits (1311), Expect = e-144, Method: Compositional matrix adjust. Identities = 234/419 (55%), Positives = 303/419 (72%) Query: 5 EWTLFSPSDTPDLHDKFGRAFEEAYTAYEAKAARGELKLFKKVQANDLWRKMLSMLFETG 64 +WTLFSP +T DL++ +G F E Y YEA A G+++ F++V A DLWR ML+ LFETG Sbjct: 348 QWTLFSPKETGDLYELYGSDFAERYREYEAMADDGDIQRFERVDATDLWRTMLTRLFETG 407 Query: 65 HPWITFKDPCNIRSPQQHVGVVHSSNLCTEITLNTNDSEIAVCNLGSVNLPAHLVNGELD 124 HPW+TFKDPCN+RSPQ H G V SSNLCTEITLNT++ E AVCNLGSVNL HL +G++D Sbjct: 408 HPWLTFKDPCNVRSPQDHAGTVRSSNLCTEITLNTSEEETAVCNLGSVNLARHLDDGDID 467 Query: 125 HAKLQKTIRTAMRMLDNVIDINYYAVKKARDSNLRHRPVGMGIMGFQDCLHIKRVPYASM 184 +L +T+ TAMRMLDNV+D+N+Y + A SN+RHRPVG+G+MGF D L RVP AS Sbjct: 468 REQLSETVETAMRMLDNVVDLNFYPTENAERSNMRHRPVGLGVMGFHDALQQMRVPMASD 527 Query: 185 DAVEFADRSMEAVCYYAYMASTELAEERGRYASYRGSLWDRGILPQDSLKLLAQERGGYL 244 DA++ AD E V Y+A AS +LA ERG Y SY GS WDR + PQD++ L ERG + Sbjct: 528 DALDRADALQEYVAYHAIGASADLAAERGTYESYEGSKWDRDVFPQDTVDRLESERGREI 587 Query: 245 ETDSTETLDWAALRARIAEHGMRNSNCVAIAPTATISNIIGVSACIEPTYQNLYVKSNLS 304 E LDW+ +R R+A HGMRNSN +A+APTATIS I G + IEP Y NLYVKSN+S Sbjct: 588 PVPREERLDWSDVRQRVATHGMRNSNTMAVAPTATISTIAGTTPSIEPVYSNLYVKSNMS 647 Query: 305 GEFTEINEYLVRDLKARGLWDEVMVADLKYFDGSLAKIDRIPQDLRDIYATAFEVDPSWL 364 G+FT +N+ LV DL+ R LW E + L Y DGS+ ++D +P+D++++Y TAFE+DP Sbjct: 648 GDFTVVNDRLVADLEERDLWTEELRDKLTYHDGSVQELDAVPEDVQELYRTAFEIDPRHQ 707 Query: 365 VEAASRRQKWIDQAQSLNIYMAGASGKRLDETYKLAWLRGLKTTYYLRTIGATHTEKST 423 + A+RR WIDQ+QS+N++ G +L E Y+ AW GLKTTYYLRT+GA+ EK+T Sbjct: 708 LRLAARRGVWIDQSQSVNVFFPETDGSKLSEVYQTAWELGLKTTYYLRTLGASQIEKTT 766