BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0008.0335.p (465 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA0667 [M] COG0739 Membrane proteins related to metalloendopepti... 263 9e-70 XF0167 [M] COG0739 Membrane proteins related to metalloendopepti... 250 4e-66 NMA2172 [M] COG0739 Membrane proteins related to metalloendopept... 226 7e-59 NMB0315 [M] COG0739 Membrane proteins related to metalloendopept... 226 9e-59 RC0557 [M] COG0739 Membrane proteins related to metalloendopepti... 199 1e-50 >PA0667 [M] COG0739 Membrane proteins related to metalloendopeptidases Pae Pseudomonas aeruginosa Length = 447 Score = 263 bits (671), Expect = 9e-70, Method: Compositional matrix adjust. Identities = 146/354 (41%), Positives = 198/354 (55%), Gaps = 8/354 (2%) Query: 96 VRSGDTLATLLNRLGVDDDEAMAFIKSDTLARSVMQLRAGKRVVAQTDDNGELVKLSATL 155 V SGDTL+T+ + G+ + S A+ L+ G+ V + D GEL L Sbjct: 87 VASGDTLSTVFTKAGLSTSAMHDMLTSSKDAKRFTHLKVGQEVKLKLDPKGELQALRVKQ 146 Query: 156 DDGSDAPKNLVISRHDGKLSAEAQPAVLERRVEMRSGVIFSSLFAATDAVQIPDAVAMQL 215 + + + + + D S + + A ++ G I SSLF A +P + L Sbjct: 147 SE----LETIGLDKTDKGYSFKREKAQIDLHTAYAHGRITSSLFVAGRNAGLPYNLVTSL 202 Query: 216 VDMFATNINFASDLRRGDRFNVVYETFWQNGDLVRTGRVLAGEFDNAGNRYQAVWFSDPA 275 ++F +I+FA DLR GD F+V+YE NG V TG +LA F N G Y AV +++ Sbjct: 203 SNIFGYDIDFALDLREGDEFDVIYEQHKVNGKQVATGNILAARFVNRGKTYTAVRYTN-- 260 Query: 276 SKTGGGGYYAFDGKSLKKAFLKSPLAFTRISSGFSM-RLHPILGKWKQHTGVDFAAPTGT 334 K G YY DG S++KAF+++P+ F RISS FS+ R HPIL K + H GVD+AAP GT Sbjct: 261 -KQGNTSYYRADGSSMRKAFIRTPVDFARISSRFSLGRRHPILNKIRAHKGVDYAAPIGT 319 Query: 335 PIHAAADGVVDFVGKQNGYGNIVVIKHWSGYSTAYGHMSRFAPDIKKGMKVSQNDVIGFV 394 PI A DG + G++ GYGN VVI+H Y T YGHMSRFA I+ G V Q +IG+V Sbjct: 320 PIKATGDGKILEAGRKGGYGNAVVIQHGQRYRTIYGHMSRFAKGIRAGTSVKQGQIIGYV 379 Query: 395 GMTGWATGPHLHYEFRVNNQPRNPLSVDVPNNQALTGPQLQRFRTVAADMQHRM 448 GMTG ATGPHLHYEF++N + +PLS +P L G +RF M RM Sbjct: 380 GMTGLATGPHLHYEFQINGRHVDPLSAKLPMADPLGGADRKRFMAQTQPMIARM 433 >XF0167 [M] COG0739 Membrane proteins related to metalloendopeptidases Xfa Xylella fastidiosa 9a5c Length = 417 Score = 250 bits (639), Expect = 4e-66, Method: Compositional matrix adjust. Identities = 134/350 (38%), Positives = 200/350 (57%), Gaps = 10/350 (2%) Query: 96 VRSGDTLATLLNRLGVDDDEAMAFIKSDTLARSVMQLRAGKRVVAQTDDNGELVKLSATL 155 ++ G TL+++ N L + ++ + L + + +L G + ++G+L + Sbjct: 48 IKPGQTLSSIFNELKLSSNDMERVLNYADLRKLLTRLSPGDEISFDIPNDGQLRGMRFNR 107 Query: 156 DDGSDAPKNLVISRHDGKLSAEAQPAVLERRVEMRSGVIFSSLFAATDAVQIPDAVAMQL 215 D+ + ++ D + + R + SG I SSL+ A + A + L Sbjct: 108 DE----KHRVELTLDDNTIHQQVSERQTSTRTVIASGEIKSSLWIAAREAGLSPADVITL 163 Query: 216 VD-MFATNINFASDLRRGDRFNVVYETFWQNGDLVRTGRVLAGEFDNAGNRYQAVWFSDP 274 D +F +I+F DL+ GDRF+VV + W+ G+ + ++LA F+ G Y + F Sbjct: 164 TDEIFKYDIDFDKDLQTGDRFSVVMDETWREGERLPDAKILAATFNTGGKIYSGMRFM-- 221 Query: 275 ASKTGGGGYYAFDGKSLKKAFLKSPLAFTRISSGFSMRLHPILGKWKQHTGVDFAAPTGT 334 + G Y+ DG+ LKK+F++ P+++ R+SS F +R HPILG + H GVD+AA TGT Sbjct: 222 --RDGKVEYFDKDGRPLKKSFIRMPISYARLSSTFGLRRHPILGTMRMHKGVDYAAATGT 279 Query: 335 PIHAAADGVVDFVGKQNGYGNIVVIKHWSGYSTAYGHMSRFAPDIKKGMKVSQNDVIGFV 394 PI AA D V F+G+Q GYGN+V++ H GY T YGHMSRF IK G K++Q VIG+V Sbjct: 280 PIMAAGDARVQFIGQQRGYGNVVILNHGKGYRTLYGHMSRFG-KIKAGQKINQGTVIGYV 338 Query: 395 GMTGWATGPHLHYEFRVNNQPRNPLSVDVPNNQALTGPQLQRFRTVAADM 444 GMTG ATGPHLHYEF+VN Q RNPLS+ +P + L G L FRT A + Sbjct: 339 GMTGLATGPHLHYEFQVNGQHRNPLSITMPPPEPLRGKDLIAFRTQTAPL 388 >NMA2172 [M] COG0739 Membrane proteins related to metalloendopeptidases NmA Neisseria meningitidis Z2491 Length = 430 Score = 226 bits (577), Expect = 7e-59, Method: Compositional matrix adjust. Identities = 145/402 (36%), Positives = 212/402 (52%), Gaps = 15/402 (3%) Query: 29 SPKTRIIGASALFLAAFTIGAAGFAPAEPDMKDAPVNPISKELALPDLQHQISALEEQSQ 88 S K R AL ++ + AA A E + V P E LP L S + Q+ Sbjct: 7 SAKHRKYALRALAVSIILVSAAYIASTE---RTERVRPQRVEQKLPPLSWGGSGV--QTA 61 Query: 89 YYVNEEKVRSGDTLATLLNRLGVDDDEAMAFIKSDTLARSVMQLRAGKRVVAQTDDNGEL 148 Y+V +E V+ GD+LA +L R G+ DE + + LRA + V +G Sbjct: 62 YWV-QEAVQPGDSLADVLARSGMARDEIARITEKYGGEADLRHLRADQSVHVLVGGDGGA 120 Query: 149 VKLSATLDDGSDAPKNLV-ISRHDGKLSAEAQPAVLERRVEMRSGVIFSSLFAATDAVQI 207 ++ D+ D +NLV + + G A A ++ +RS V+ +S + ++ Sbjct: 121 REVQFFTDE--DGERNLVALEKKGGIWRRSASEADMKVLPTLRSVVVKTSARGSLARAEV 178 Query: 208 PDAVAMQLVDMFATNINFASDLRRGDRFNVVYETFWQNGDLVRTGRVLAGEFDNAGNRYQ 267 P + L +FA + L+ GD ++Y++ + +G V G +LA E G R+Q Sbjct: 179 PVEIRESLSGIFAGRFSL-DGLKEGDAVRLIYDSLYFHGQQVAAGDILAAEVVKGGTRHQ 237 Query: 268 AVWFSDPASKTGGGGYYAFDGKSL--KKAFLKSPLAFTRISSGFSMRLHPILGKWKQHTG 325 A ++ GGG YY DG+ L K F PL +TRISS F R+HPIL W+ HTG Sbjct: 238 AFYYRSDKEGGGGGNYYDEDGRVLQEKGGFNIEPLVYTRISSPFGYRMHPILHTWRLHTG 297 Query: 326 VDFAAPTGTPIHAAADGVVDFVGKQNGYGNIVVIKHWSGYSTAYGHMSRFAPDIKKGMKV 385 +D+AAP GTP+ A+ADGV+ F G++ GYGN V+I+H +G T Y H+S F+ + V Sbjct: 298 IDYAAPQGTPVRASADGVITFKGRKGGYGNAVMIRHANGVETLYAHLSAFS---QAEGNV 354 Query: 386 SQNDVIGFVGMTGWATGPHLHYEFRVNNQPRNPLSVDVPNNQ 427 +VIGFVG TG +TGPHLHYE R+N QP NP+SV +P + Sbjct: 355 RGGEVIGFVGSTGRSTGPHLHYEARINGQPVNPVSVALPTPE 396 >NMB0315 [M] COG0739 Membrane proteins related to metalloendopeptidases Nme Neisseria meningitidis MC58 Length = 430 Score = 226 bits (576), Expect = 9e-59, Method: Compositional matrix adjust. Identities = 146/400 (36%), Positives = 211/400 (52%), Gaps = 15/400 (3%) Query: 29 SPKTRIIGASALFLAAFTIGAAGFAPAEPDMKDAPVNPISKELALPDLQHQISALEEQSQ 88 S K R AL ++ + AA A E + V P E LP L S + Q+ Sbjct: 7 SAKHRKYALRALAVSIILVSAAYIASTE---RTERVRPQRVEQNLPPLSWGGSGV--QTA 61 Query: 89 YYVNEEKVRSGDTLATLLNRLGVDDDEAMAFIKSDTLARSVMQLRAGKRVVAQTDDNGEL 148 Y+V +E V+ GD+LA +L R G+ DE + + LRA + V +G Sbjct: 62 YWV-QEAVQPGDSLADVLARSGMARDEIARITEKYGGEADLRHLRADQSVHVLVGGDGGA 120 Query: 149 VKLSATLDDGSDAPKNLV-ISRHDGKLSAEAQPAVLERRVEMRSGVIFSSLFAATDAVQI 207 ++ D+ D +NLV + + G A A ++ +RS V+ +S + ++ Sbjct: 121 REVQFFTDE--DGERNLVALEKKGGIWRRSASEADMKVLPTLRSVVVKTSARGSLARAEV 178 Query: 208 PDAVAMQLVDMFATNINFASDLRRGDRFNVVYETFWQNGDLVRTGRVLAGEFDNAGNRYQ 267 P + L +FA + L+ GD ++Y++ + +G V G +LA E G R+Q Sbjct: 179 PVEIRESLSGIFAGRFSL-DGLKEGDAVRLMYDSLYFHGQQVAAGDILAAEVVKGGTRHQ 237 Query: 268 AVWFSDPASKTGGGGYYAFDGKSL--KKAFLKSPLAFTRISSGFSMRLHPILGKWKQHTG 325 A ++ GGG YY DGK L K F PL +TRISS F R+HPIL W+ HTG Sbjct: 238 AFYYRSDKEGGGGGNYYDEDGKVLQEKGGFNIEPLVYTRISSPFGYRMHPILHTWRLHTG 297 Query: 326 VDFAAPTGTPIHAAADGVVDFVGKQNGYGNIVVIKHWSGYSTAYGHMSRFAPDIKKGMKV 385 +D+AAP GTP+ A+ADGV+ F G++ GYGN V+I+H +G T Y H+S F+ + V Sbjct: 298 IDYAAPQGTPVRASADGVITFKGRKGGYGNAVMIRHANGVETLYAHLSAFS---QAEGNV 354 Query: 386 SQNDVIGFVGMTGWATGPHLHYEFRVNNQPRNPLSVDVPN 425 +VIGFVG TG +TGPHLHYE R+N QP NP+SV +P Sbjct: 355 RGGEVIGFVGSTGRSTGPHLHYEARINGQPVNPVSVALPT 394 >RC0557 [M] COG0739 Membrane proteins related to metalloendopeptidases Rco Rickettsia conorii Length = 476 Score = 199 bits (506), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 121/394 (30%), Positives = 206/394 (52%), Gaps = 24/394 (6%) Query: 65 NPISKELALPDLQHQISALEEQSQYYVNEEKVRSGDTLATLLNRLGV---DDDEAMAFIK 121 N +S L PD S+ EE + E V+ GDT+ ++L + + D+ ++ IK Sbjct: 74 NTLSITLVQPD-----SSEEETISF--KEVVVKKGDTIKSILIEQHIPKNEIDKIVSLIK 126 Query: 122 SDTLARSVMQLRAGKRVVAQ------TDDNGELVKLSATLDDGS---DAPKNLVISRHDG 172 L+ + L+ G+++ + +++ +L A L+ D K + + R Sbjct: 127 EGKLSSA---LKIGQQITFEYETKIIENEDEDLTSEVAFLNKIVIIIDKLKTIEVIREGD 183 Query: 173 KLSAEAQPAVLERRVEMRSGVIFSSLFAATDAVQIPDAVAMQLVDMFATNINFASDLRRG 232 E L ++V S I ++ +A + + D ++L++ +A I+F ++RG Sbjct: 184 NFKVEEIVVPLSKKVAKSSVSIEANFMSALKKLGLSDNSIIELINAYAYQIDFQRQIKRG 243 Query: 233 DRFNVVYETF-WQNGDLVRTGRVLAGEFDNAGNRYQAVWFSDPASKTGGGGYYAFDGKSL 291 D V+ E + ++G G++L + +G Y +S + +++ DGKS+ Sbjct: 244 DTATVITEKYVTEDGKFSHHGKILYVSLNLSGKEYNIYRYSHD-NNANNHAFFSEDGKSV 302 Query: 292 KKAFLKSPLAFTRISSGFSMRLHPILGKWKQHTGVDFAAPTGTPIHAAADGVVDFVGKQN 351 K++ LK+PL ++SS + R HPILG K H GVDFAAPTGTPI++A +GV+ +G ++ Sbjct: 303 KRSLLKTPLKVIKVSSHYGNRKHPILGYTKMHRGVDFAAPTGTPIYSAGNGVITEIGWKS 362 Query: 352 GYGNIVVIKHWSGYSTAYGHMSRFAPDIKKGMKVSQNDVIGFVGMTGWATGPHLHYEFRV 411 GYG + +KH STAY H S FA ++K G V Q +I +VG TG AT PHLHYE ++ Sbjct: 363 GYGKFIQVKHSGTLSTAYAHASNFAKNLKVGSIVKQGQIIAYVGSTGRATAPHLHYEVKI 422 Query: 412 NNQPRNPLSVDVPNNQALTGPQLQRFRTVAADMQ 445 + + NP+SV L G L++F+ +++ Sbjct: 423 DGKHVNPMSVKTTPGIELNGKNLEKFKQFKKEIK 456