BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0008.0302.p (399 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA1993 [GEPR] COG0477 Permeases of the major facilitator superfa... 402 e-112 yhhS [GEPR] COG0477 Permeases of the major facilitator superfami... 328 1e-89 ZyhhS [GEPR] COG0477 Permeases of the major facilitator superfam... 324 2e-88 ECs4322 [GEPR] COG0477 Permeases of the major facilitator superf... 324 2e-88 STM3581 [GEPR] COG0477 Permeases of the major facilitator superf... 323 3e-88 >PA1993 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 402 Score = 402 bits (1034), Expect = e-112, Method: Compositional matrix adjust. Identities = 221/397 (55%), Positives = 286/397 (72%), Gaps = 6/397 (1%) Query: 7 RPLTPAK------VTRQIIATAFFTFLVYLAIGIPMAVLPGYIHLDLGYSSVMAGLGISV 60 RP PA+ VT QI++ FTF+ YL IGIP+AVLPGY+H DLGY SV+AGL IS+ Sbjct: 6 RPTPPAQDSARQNVTLQIVSVVMFTFIGYLTIGIPLAVLPGYVHDDLGYGSVLAGLVISL 65 Query: 61 QYFATFVSRANAGRMIDTVGAKQTVMRGMLLCSASGALLLCSALAQPLPFLSLVLLFASR 120 QY AT ++R AGR+ID +G K+ V+ GM +ASG +L S Q P LSL L R Sbjct: 66 QYLATLLARPYAGRVIDGLGPKRAVLYGMAGSAASGLFMLLSVAIQGWPALSLASLLVGR 125 Query: 121 ALLGLGESLVGTGAIMWGVGRVGSENTAKMISWNGIATYAALAIGAPLGVVLDRSLGFAM 180 +LG ESLVG+ AI WG+GRVG+ +TAK+ISWNGIA+Y A+A+GAPLGV+L + LG Sbjct: 126 LVLGAAESLVGSAAIGWGIGRVGAPHTAKVISWNGIASYGAIALGAPLGVLLVQWLGLWS 185 Query: 181 IGLSGMLLTALGYVLARGGPVTPVVQGEQLSFKLVLRKVFAYGMGLAFGTIGFGSIATFI 240 +G S +LL ALG+ LA P+V GE+L F VL +V +GMGLA G IGFG+IATFI Sbjct: 186 MGASIVLLGALGFALAWPKLPAPLVHGERLPFHHVLGRVTPHGMGLALGAIGFGTIATFI 245 Query: 241 TLYYADLHWSGAAFALTAFSSAFVGARLLFANAITRFGGYRVAVVSFLTEAVGLLLLWSA 300 TLYYA W+ A L+AF F+GARLLFAN+I R GG+RVA++ E++GLLLLWSA Sbjct: 246 TLYYASRGWANAVLCLSAFGGCFIGARLLFANSINRLGGFRVAIICLGVESLGLLLLWSA 305 Query: 301 TTPELALLGAGLAGFGFALVFPSLGVEAVNLVSPANRGAALAAYSVFLDLALGITGPLAG 360 P + L GA L GFGF+LVFP+ GVEAVNLV +NRGAAL AYS+F+DL+LGITGPL G Sbjct: 306 PNPWVGLAGAALTGFGFSLVFPAFGVEAVNLVPASNRGAALGAYSLFVDLSLGITGPLVG 365 Query: 361 AIAGQLGYPQVFLFAAIAAIGAVALSLSLYRSAQQRG 397 +A G+ +FLFA +A++G +AL+++L+R +++ G Sbjct: 366 FVANLFGFRSMFLFACLASLGGLALAVALHRRSRRPG 402 >yhhS [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 419 Score = 328 bits (841), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 193/395 (48%), Positives = 256/395 (64%), Gaps = 5/395 (1%) Query: 2 PAAPPRPLTPAKVTRQIIATAFFTFLVYLAIGIPMAVLPGYIHLDLGYSSVMAGLGISVQ 61 P A P L ++ +I++ F F YL IG+P+AVLPGY+H +G+S+ AGL IS+Q Sbjct: 18 PVAEPA-LNGLRLNLRIVSIVMFNFASYLTIGLPLAVLPGYVHDVMGFSAFWAGLVISLQ 76 Query: 62 YFATFVSRANAGRMIDTVGAKQTVMRGMLLCSASGALLLCSALAQPLPFLSLVLLFASRA 121 YFAT +SR +AGR D++G K+ V+ G+ C SG L + L LP +SL+LL R Sbjct: 77 YFATLLSRPHAGRYADSLGPKKIVVFGLCGCFLSGLGYLTAGLTASLPVISLLLLCLGRV 136 Query: 122 LLGLGESLVGTGAIMWGVGRVGSENTAKMISWNGIATYAALAIGAPLGVVLDRSLGFAMI 181 +LG+G+S GTG+ +WGVG VGS + ++ISWNGI TY A+A+GAPLGVV G + Sbjct: 137 ILGIGQSFAGTGSTLWGVGVVGSLHIGRVISWNGIVTYGAMAMGAPLGVVFYHWGGLQAL 196 Query: 182 GLSGMLLTALGYVLARGGPVTPVVQGEQLSFKLVLRKVFAYGMGLAFGTIGFGSIATFIT 241 L M + + +LA P +G+ L F+ VL +V+ YGM LA + GFG IATFIT Sbjct: 197 ALIIMGVALVAILLAIPRPTVKASKGKPLPFRAVLGRVWLYGMALALASAGFGVIATFIT 256 Query: 242 LYYADLHWSGAAFALTAFSSAFVGARLLFANAITRFGGYRVAVVSFLTEAVGLLLLWSAT 301 L+Y W GAAFALT FS AFVG RLLF N I R GG VA++ F E +GLLL+ AT Sbjct: 257 LFYDAKGWDGAAFALTLFSCAFVGTRLLFPNGINRIGGLNVAMICFSVEIIGLLLVGVAT 316 Query: 302 TPELALLGAGLAGFGFALVFPSLGVEAVNLVSPANRGAALAAYSVFLDLALGITGPLAGA 361 P +A +G LAG GF+LVFP+LGV AV V N+GAALA Y+VF+DL+LG+TGPLAG Sbjct: 317 MPWMAKIGVLLAGAGFSLVFPALGVVAVKAVPQQNQGAALATYTVFMDLSLGVTGPLAGL 376 Query: 362 IAGQLGYPQVFLFAAIAAIGAVALSLSLYRSAQQR 396 + G P ++L AA G VA++L L ++R Sbjct: 377 VMSWAGVPVIYL----AAAGLVAIALLLTWRLKKR 407 >ZyhhS [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 419 Score = 324 bits (830), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 192/395 (48%), Positives = 254/395 (64%), Gaps = 5/395 (1%) Query: 2 PAAPPRPLTPAKVTRQIIATAFFTFLVYLAIGIPMAVLPGYIHLDLGYSSVMAGLGISVQ 61 P A P L ++ +I++ F F YL IG+P+AVLPGY+H +G+S+ AGL IS+Q Sbjct: 18 PVAEPA-LNGLRLNLRILSIVMFNFASYLTIGLPLAVLPGYVHDVMGFSAFWAGLVISLQ 76 Query: 62 YFATFVSRANAGRMIDTVGAKQTVMRGMLLCSASGALLLCSALAQPLPFLSLVLLFASRA 121 YFAT +SR +AGR D +G K+ V+ G+ C SG L + L LP +SL+LL R Sbjct: 77 YFATLLSRPHAGRYADLLGPKKIVVFGLCGCFLSGLGYLTAGLTASLPVISLLLLCLGRV 136 Query: 122 LLGLGESLVGTGAIMWGVGRVGSENTAKMISWNGIATYAALAIGAPLGVVLDRSLGFAMI 181 +LG+G+S GTG+ +WGVG VGS + ++ISWN I TY A+A+GAPLGVV G + Sbjct: 137 ILGIGQSFAGTGSTLWGVGVVGSLHIGRVISWNDIVTYGAMAMGAPLGVVFYHWGGLQAL 196 Query: 182 GLSGMLLTALGYVLARGGPVTPVVQGEQLSFKLVLRKVFAYGMGLAFGTIGFGSIATFIT 241 L M + + +LA P +G+ L F+ VL +V+ YGM LA + GFG IATFIT Sbjct: 197 ALIIMGVALVAILLAIPRPTVKASKGKPLPFRAVLGRVWLYGMALALASAGFGVIATFIT 256 Query: 242 LYYADLHWSGAAFALTAFSSAFVGARLLFANAITRFGGYRVAVVSFLTEAVGLLLLWSAT 301 L+Y W GAAFALT FS AFVG RLLF N I R GG VA++ F E +GLLL+ AT Sbjct: 257 LFYDVKGWDGAAFALTLFSCAFVGTRLLFPNGINRIGGLNVAMICFSVEIIGLLLVGVAT 316 Query: 302 TPELALLGAGLAGFGFALVFPSLGVEAVNLVSPANRGAALAAYSVFLDLALGITGPLAGA 361 P +A +G LAG GF+LVFP+LGV AV V N+GAALA Y+VF+DL+LG+TGPLAG Sbjct: 317 MPWMAKIGVLLAGAGFSLVFPALGVVAVKAVPQQNQGAALATYTVFMDLSLGVTGPLAGL 376 Query: 362 IAGQLGYPQVFLFAAIAAIGAVALSLSLYRSAQQR 396 + G P ++L AA G VA++L L ++R Sbjct: 377 VMSWAGVPVIYL----AAAGLVAIALLLTWRLKKR 407 >ECs4322 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 419 Score = 324 bits (830), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 192/395 (48%), Positives = 254/395 (64%), Gaps = 5/395 (1%) Query: 2 PAAPPRPLTPAKVTRQIIATAFFTFLVYLAIGIPMAVLPGYIHLDLGYSSVMAGLGISVQ 61 P A P L ++ +I++ F F YL IG+P+AVLPGY+H +G+S+ AGL IS+Q Sbjct: 18 PVAEPA-LNGLRLNLRILSIVMFNFASYLTIGLPLAVLPGYVHDVMGFSAFWAGLVISLQ 76 Query: 62 YFATFVSRANAGRMIDTVGAKQTVMRGMLLCSASGALLLCSALAQPLPFLSLVLLFASRA 121 YFAT +SR +AGR D +G K+ V+ G+ C SG L + L LP +SL+LL R Sbjct: 77 YFATLLSRPHAGRYADLLGPKKIVVFGLCGCFLSGLGYLTAGLTASLPVISLLLLCLGRV 136 Query: 122 LLGLGESLVGTGAIMWGVGRVGSENTAKMISWNGIATYAALAIGAPLGVVLDRSLGFAMI 181 +LG+G+S GTG+ +WGVG VGS + ++ISWN I TY A+A+GAPLGVV G + Sbjct: 137 ILGIGQSFAGTGSTLWGVGVVGSLHIGRVISWNDIVTYGAMAMGAPLGVVFYHWGGLQAL 196 Query: 182 GLSGMLLTALGYVLARGGPVTPVVQGEQLSFKLVLRKVFAYGMGLAFGTIGFGSIATFIT 241 L M + + +LA P +G+ L F+ VL +V+ YGM LA + GFG IATFIT Sbjct: 197 ALIIMGVALVAILLAIPRPTVKASKGKPLPFRAVLGRVWLYGMALALASAGFGVIATFIT 256 Query: 242 LYYADLHWSGAAFALTAFSSAFVGARLLFANAITRFGGYRVAVVSFLTEAVGLLLLWSAT 301 L+Y W GAAFALT FS AFVG RLLF N I R GG VA++ F E +GLLL+ AT Sbjct: 257 LFYDVKGWDGAAFALTLFSCAFVGTRLLFPNGINRIGGLNVAMICFSVEIIGLLLVGVAT 316 Query: 302 TPELALLGAGLAGFGFALVFPSLGVEAVNLVSPANRGAALAAYSVFLDLALGITGPLAGA 361 P +A +G LAG GF+LVFP+LGV AV V N+GAALA Y+VF+DL+LG+TGPLAG Sbjct: 317 MPWMAKIGVLLAGAGFSLVFPALGVVAVKAVPQQNQGAALATYTVFMDLSLGVTGPLAGL 376 Query: 362 IAGQLGYPQVFLFAAIAAIGAVALSLSLYRSAQQR 396 + G P ++L AA G VA++L L ++R Sbjct: 377 VMSWAGVPVIYL----AAAGLVAIALLLTWRLKKR 407 >STM3581 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 419 Score = 323 bits (829), Expect = 3e-88, Method: Compositional matrix adjust. Identities = 193/400 (48%), Positives = 257/400 (64%), Gaps = 15/400 (3%) Query: 2 PAAPPRPLTPAKVTRQIIATAFFTFLVYLAIGIPMAVLPGYIHLDLGYSSVMAGLGISVQ 61 P A P L ++ +I++ F F YL IG+P+AVLPGY+H +G+S+ AGL IS+Q Sbjct: 18 PVAEPA-LNGLRLNLRIVSIVMFNFASYLTIGLPLAVLPGYVHDAMGFSAFWAGLIISLQ 76 Query: 62 YFATFVSRANAGRMIDTVGAKQTVMRGMLLCSASGALLLCSALAQPLPFLSLVLLFASRA 121 YFAT +SR +AGR D +G K+ V+ G+ C SG L + +A P +SL+LL R Sbjct: 77 YFATLLSRPHAGRYADVLGPKKIVVFGLCGCFLSGLGYLLADIASAWPMISLLLLGLGRV 136 Query: 122 LLGLGESLVGTGAIMWGVGRVGSENTAKMISWNGIATYAALAIGAPLGVVLDRSLGFAMI 181 +LG+G+S GTG+ +WGVG VGS + ++ISWNGI TY A+A+GAPLGV L +A Sbjct: 137 ILGIGQSFAGTGSTLWGVGVVGSLHIGRVISWNGIVTYGAMAMGAPLGV-----LCYAWG 191 Query: 182 GLSGMLLTALGYVLARGG-----PVTPVVQGEQLSFKLVLRKVFAYGMGLAFGTIGFGSI 236 GL G+ LT +G L P +G+ L F+ VL +V+ YGM LA + GFG I Sbjct: 192 GLQGLALTVMGVALLAVLLALPRPSVKANKGKPLPFRAVLGRVWLYGMALALASAGFGVI 251 Query: 237 ATFITLYYADLHWSGAAFALTAFSSAFVGARLLFANAITRFGGYRVAVVSFLTEAVGLLL 296 ATFITL+Y W GAAFALT FS AFVG RLLF N I R GG VA++ F E +GLLL Sbjct: 252 ATFITLFYDAKGWDGAAFALTLFSVAFVGTRLLFPNGINRLGGLNVAMICFGVEIIGLLL 311 Query: 297 LWSATTPELALLGAGLAGFGFALVFPSLGVEAVNLVSPANRGAALAAYSVFLDLALGITG 356 + +A P +A +G L G GF+LVFP+LGV AV V P N+GAALA Y+VF+D++LG+TG Sbjct: 312 VGTAAMPWMAKIGVLLTGMGFSLVFPALGVVAVKAVPPQNQGAALATYTVFMDMSLGVTG 371 Query: 357 PLAGAIAGQLGYPQVFLFAAIAAIGAVALSLSLYRSAQQR 396 PLAG + G P ++L AA G VA++L L ++R Sbjct: 372 PLAGLVMTWAGVPVIYL----AAAGLVAMALLLTWRLKKR 407