BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0008.0174.p (305 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2225 [GER] COG0697 Permeases of the drug/metabolite transport... 267 3e-71 NMA1785 [GER] COG0697 Permeases of the drug/metabolite transport... 162 1e-39 NMB1593 [GER] COG0697 Permeases of the drug/metabolite transport... 159 1e-38 YPO1348 [GER] COG0697 Permeases of the drug/metabolite transport... 106 7e-23 PA2628 [GER] COG0697 Permeases of the drug/metabolite transporte... 100 4e-21 >RSc2225 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 324 Score = 267 bits (682), Expect = 3e-71, Method: Compositional matrix adjust. Identities = 147/291 (50%), Positives = 198/291 (68%), Gaps = 5/291 (1%) Query: 2 QSLWMLVASFLFSIMGVCVKLASDYYSTSEIVLCRGLIGISVIAALVRVRGGTFRTPFPR 61 QSLWM++A+F FS MGVCVKLAS +YST EIV R LIG++++ A++ G RTP Sbjct: 19 QSLWMVLAAFAFSAMGVCVKLASAHYSTGEIVFYRSLIGVALMGAVLYHTGAGVRTPHFA 78 Query: 62 DHLIRGGVGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWWQGNK-KFEWGL 120 H+ R GV SL LWF S SLLP+ATA TLNYMS +WIA+++ A A G + + Sbjct: 79 SHIKRSVFGVTSLLLWFSSISLLPLATAMTLNYMSPVWIALIIGAGATLAGKAGGADRKM 138 Query: 121 AATVVLSFIGVALLMRPSLDADQLLGGAISLFSGVLSALVYLQVRKLGLLGEPEYRVVFY 180 +++SF+GV L++PS+ Q+ GG I L SGV +AL Y++VR+LG LGE E R+VFY Sbjct: 139 VTAILMSFVGVICLLQPSVGPSQMTGGMIGLVSGVFTALAYVEVRQLGDLGENEARIVFY 198 Query: 181 FSLTGVLAGLVGSVATGRVPLWHSHSWQGAALVIMIGLTATLAQIAMTRAYRLGNTLVTA 240 FSL +AG + G H+H+WQ A L++ +GL ATL Q AMTRAY+ GNTL+TA Sbjct: 199 FSLVSSIAGGAWMLIAGA----HAHTWQSAWLLVAVGLLATLGQTAMTRAYKRGNTLLTA 254 Query: 241 NLQYTGIVFSSLFGVLVWNDAPGWLGWLGMGVILASGLLATYHNHRSSQIA 291 NLQYTGIVF+S +G+L+W+D L W+GM +I+ SG++ T R S +A Sbjct: 255 NLQYTGIVFASGWGMLLWHDHLNALSWMGMALIIGSGIVTTVMRARQSGVA 305 >NMA1785 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily NmA Neisseria meningitidis Z2491 Length = 300 Score = 162 bits (410), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 108/279 (38%), Positives = 159/279 (56%), Gaps = 10/279 (3%) Query: 5 WMLVASFLFSIMGVCVKLASDYYS--TSEIVLCRGLIGISVIAALVRVRGGTFRTPFPRD 62 WMLVA+ F+IM V +K AS ++ + E+V R L + A +R TFRTP ++ Sbjct: 13 WMLVAAACFTIMNVLIKEASAKFALGSGELVFWRMLFSTVALGAAAVLRRDTFRTPHWKN 72 Query: 63 HLIRGGVGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWWQGNKKFEWGLAA 122 HL R VG ++ L FY+ + LP+AT TL+Y SSI++AV F ++ A Sbjct: 73 HLNRSMVGTGAMLLLFYAVTHLPLATGVTLSYTSSIFLAVFSFLIL----KERISVYTQA 128 Query: 123 TVVLSFIGVALLMRPSLDADQLLGGAISLFSGVLSALVYLQVRKLGLLGEPEYRVVFYFS 182 ++L F GV LL+ PS + Q L G +S YL+VR+L L GEP +RVVFY S Sbjct: 129 VLLLGFAGVVLLLNPSFRSGQETAALAGLAGGAMSGWAYLKVRELSLAGEPGWRVVFYLS 188 Query: 183 LTGVLAGLVGSVATGRVPLWHSHSWQGAALVIMIGLTATLAQIAMTRAYRLGNTLVTANL 242 +TGV V + TG WH+ S+ A + IG++A +AQ++MTRAY++G+ A+L Sbjct: 189 VTGVAMSSVWATLTG----WHTLSFPSAVYLSCIGVSALIAQLSMTRAYKVGDKFTVASL 244 Query: 243 QYTGIVFSSLFGVLVWNDAPGWLGWLGMGVILASGLLAT 281 Y +VFS+L + W LGM +I+ SG+L++ Sbjct: 245 SYMTVVFSALSAAFFLAEELFWQEILGMCIIILSGILSS 283 >NMB1593 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Nme Neisseria meningitidis MC58 Length = 287 Score = 159 bits (401), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 107/278 (38%), Positives = 158/278 (56%), Gaps = 10/278 (3%) Query: 6 MLVASFLFSIMGVCVKLASDYYS--TSEIVLCRGLIGISVIAALVRVRGGTFRTPFPRDH 63 MLVA+ F+IM V +K AS ++ + E+V R L + A +R TFRTP ++H Sbjct: 1 MLVAAACFTIMNVLIKEASAKFALGSGELVFWRMLFSTVALGAAAVLRRDTFRTPHWKNH 60 Query: 64 LIRGGVGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWWQGNKKFEWGLAAT 123 L R VG ++ L FY+ + LP+AT TL+Y SSI++AV F ++ A Sbjct: 61 LNRSMVGTGAMLLLFYAVTHLPLATGVTLSYTSSIFLAVFSFLIL----KERISVYTQAV 116 Query: 124 VVLSFIGVALLMRPSLDADQLLGGAISLFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSL 183 ++L F GV LL+ PS + Q L G +S YL+VR+L L GEP +RVVFY S+ Sbjct: 117 LLLGFAGVVLLLNPSFRSGQETAALAGLAGGAMSGWAYLKVRELSLAGEPGWRVVFYLSV 176 Query: 184 TGVLAGLVGSVATGRVPLWHSHSWQGAALVIMIGLTATLAQIAMTRAYRLGNTLVTANLQ 243 TGV V + TG WH+ S+ A + IG++A +AQ++MTRAY++G+ A+L Sbjct: 177 TGVAMSSVWATLTG----WHTLSFPSAVYLSCIGVSALIAQLSMTRAYKVGDKFTVASLS 232 Query: 244 YTGIVFSSLFGVLVWNDAPGWLGWLGMGVILASGLLAT 281 Y +VFS+L + W LGM +I+ SG+L++ Sbjct: 233 YMTVVFSALSAAFFLGEELFWQEILGMCIIILSGILSS 270 >YPO1348 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Ype Yersinia pestis Length = 281 Score = 106 bits (264), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 85/278 (30%), Positives = 138/278 (49%), Gaps = 18/278 (6%) Query: 3 SLWMLVASFLFSIMGVCVKLASDYYSTSEIVLCRGLIGISVIAALVRVRGGTFRTPFPRD 62 +L ++AS +FS+M V VK +D T EIV R IG +I L+ RG F Sbjct: 5 ALLAILASLIFSVMNVLVKTIADEIPTGEIVFFRSSIGCLLIGLLMYQRGIAFSREDRPL 64 Query: 63 HLIRGGVGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWWQGNKKFEWGLAA 122 ++RG +G + L +FYS + L +A A+ L Y+S + V+ ++ +A Sbjct: 65 LVLRGTMGALYLICYFYSIAHLTLADASMLAYLSPFFSIVLSLLVL----RERVNATMAF 120 Query: 123 TVVLSFIGVALLMRPSLDADQLLGGAISLFSGVLSALVYLQVRKLGLLGEPEYRVVFYFS 182 +V+ IG +L+RP + L + + S V +A+ YL V KL Y +VFYF Sbjct: 121 WLVMVIIGAIILIRPWNFSTYTLASLVGVMSAVFAAIAYLSVNKLTK-RHHNYEIVFYFL 179 Query: 183 LTGVLAGLVGSVATGRVPL-WHSHSWQGA---ALVIMIGLTATLAQIAMTRAYRLGNTLV 238 L +PL WH+ W ++I I L + L Q+ +T+A+ N +V Sbjct: 180 FITTLIS---------IPLMWHNFVWPSGYQFGILIAIALVSLLGQVVLTQAFSSDNLIV 230 Query: 239 TANLQYTGIVFSSLFGVLVWNDAPGWLGWLGMGVILAS 276 + ++Y GIVF+ +G L W++ P L +G G+++ S Sbjct: 231 VSVVRYIGIVFNITWGWLFWDEVPLMLSLMGGGLVVVS 268 >PA2628 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pae Pseudomonas aeruginosa Length = 296 Score = 100 bits (249), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 85/289 (29%), Positives = 143/289 (49%), Gaps = 24/289 (8%) Query: 8 VASFLFSIMGVCVKLASDYYSTSEIVLCRGLIGISVIAALVRVRG-GTFRTPFPRDHLIR 66 +++ F++MG ++ AS + +V R L+G+ L RG G RT P HL+R Sbjct: 23 LSALFFALMGGLIREASSTVNNETVVFFRNLVGVLFFLPLALTRGIGPLRTRRPLSHLLR 82 Query: 67 GGVGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWWQGNKKFEWGLAATVVL 126 G+ ++ +FY+ + LP+ A +Y + ++ ++ A W + AT+V Sbjct: 83 TTYGLGGMYCYFYALAHLPLTDAMLFSYAAPVFTPLI---AHLWIKEPLTRRMMVATLV- 138 Query: 127 SFIGVALLMRPS---LDADQLLGGAISLFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSL 183 F+GV L+ RPS + L+G A SL ++A ++ +R++ EP YR+VFYF+L Sbjct: 139 GFLGVLLVARPSGAVVAPIALVGIASSL----MAACAFVSIREMSD-SEPAYRIVFYFAL 193 Query: 184 TGVLAGLVGSVATGRVPL---WHSHSWQGAALVIMIGLTATLAQIAMTRAYRLGNTLVTA 240 G L VPL W + Q L++ GL A+L Q+ M++AY L + V Sbjct: 194 FGTL--------FSAVPLAWAWQPLNGQELLLLLGAGLFASLGQLTMSQAYALASPGVIG 245 Query: 241 NLQYTGIVFSSLFGVLVWNDAPGWLGWLGMGVILASGLLATYHNHRSSQ 289 + Y IVF+ + L W++ P LG +I A+ L+ N + + Sbjct: 246 PIAYMAIVFAGVIAWLRWDELPSHTSLLGAALIFAASLIPLLGNRPAER 294