BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0008.0017.p (310 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0914 [M] COG2870 ADP-heptose synthase, bifunctional sugar kin... 389 e-108 NMB0825 [M] COG2870 ADP-heptose synthase, bifunctional sugar kin... 362 e-100 NMA1034 [M] COG2870 ADP-heptose synthase, bifunctional sugar kin... 361 1e-99 rfaE [M] COG2870 ADP-heptose synthase, bifunctional sugar kinase... 307 2e-83 Z4405 [M] COG2870 ADP-heptose synthase, bifunctional sugar kinas... 306 4e-83 >RSc0914 [M] COG2870 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Rso Ralstonia solanacearum Length = 319 Score = 389 bits (998), Expect = e-108, Method: Compositional matrix adjust. Identities = 194/298 (65%), Positives = 241/298 (80%) Query: 12 ARILVVGDVMLDRYWFGEVNRISPEAPVPVVRVERKEERLGGAANVARNIASLGAQTALL 71 ARILVVGD+MLDRYWFG+V RISPEAPVPVV+++R +ERLGGAANVARN+A+LGAQ +L Sbjct: 18 ARILVVGDMMLDRYWFGDVERISPEAPVPVVQIKRSDERLGGAANVARNVAALGAQAGML 77 Query: 72 GVTGDDEPARVMDAMLREMGIASHLNRDPSISTIVKLRVIGRQQQLVRIDFEEAPTDTVL 131 GV G+DEP R ++A+L + HL+RDPS++T +KLRV+ RQQQL+R+DFE PT VL Sbjct: 78 GVIGEDEPGRTIEALLDASHVRGHLHRDPSVNTTIKLRVLARQQQLIRVDFENPPTHEVL 137 Query: 132 RDKLTQFNTLVADYDVILFSDYAKGSLVNVAEMIATARKLGKRILVDPKGDDFQRYVGAS 191 L +F TL+ ++DV++ SDY KG L +VA+MI AR+ G+R+LVDPKGDD+ RY GA+ Sbjct: 138 ISVLDRFGTLLPEHDVVVLSDYGKGGLTHVAKMIEAARQAGRRVLVDPKGDDYSRYKGAT 197 Query: 192 LLTPNKSELVRIVGQWKNEDDLTARAQKLRAELQLEALLLTRSEEGMSLYRDGEVTHFPT 251 ++TPN++E+ ++VG WK E DLT RAQ LR ELQLEALLLTRSEEGM+LY + EV H Sbjct: 198 MITPNRAEMRQVVGSWKTEADLTIRAQNLRRELQLEALLLTRSEEGMTLYTEHEVLHVSA 257 Query: 252 MAREVFDVSGAGDTVIGTLAVMLGAGASLVEAVTMANRAGGIVVGKLGTATVTREELL 309 AREV+DVSGAGDTVI TLA +LGAGA++ EAV ANRAGGIVVGKLGTA VT EL Sbjct: 258 QAREVYDVSGAGDTVIATLATLLGAGANIKEAVQYANRAGGIVVGKLGTAVVTYAELF 315 >NMB0825 [M] COG2870 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Nme Neisseria meningitidis MC58 Length = 323 Score = 362 bits (928), Expect = e-100, Method: Compositional matrix adjust. Identities = 171/305 (56%), Positives = 232/305 (76%) Query: 5 LLSAWSNARILVVGDVMLDRYWFGEVNRISPEAPVPVVRVERKEERLGGAANVARNIASL 64 L S ++ A++LVVGDVMLDRYWFG+V+RISPEAPVPV ++ R ++R GGAANVARNIASL Sbjct: 10 LKSRFAQAKVLVVGDVMLDRYWFGDVSRISPEAPVPVAKIGRIDQRAGGAANVARNIASL 69 Query: 65 GAQTALLGVTGDDEPARVMDAMLREMGIASHLNRDPSISTIVKLRVIGRQQQLVRIDFEE 124 G + LL VTG+DE A +DA++ + G+AS+L RD I+T VKLRV+ R QQL+R+DFEE Sbjct: 70 GGRAGLLSVTGNDEAADALDALMVQDGVASYLMRDKQIATTVKLRVVARNQQLIRLDFEE 129 Query: 125 APTDTVLRDKLTQFNTLVADYDVILFSDYAKGSLVNVAEMIATARKLGKRILVDPKGDDF 184 P VL ++ ++ +YD I+FSDY KG L ++++MI A+ GK +L+DPKGDD+ Sbjct: 130 HPNCEVLEQIKQKYREILPEYDAIIFSDYGKGGLSHISDMIDWAKHAGKTVLIDPKGDDY 189 Query: 185 QRYVGASLLTPNKSELVRIVGQWKNEDDLTARAQKLRAELQLEALLLTRSEEGMSLYRDG 244 ++YVGA+L+TPN++EL +VG WKNE +LT +AQ LR L L A+LLTRSEEGM+L+ +G Sbjct: 190 EKYVGATLITPNRAELKEVVGSWKNESELTEKAQNLRRHLDLTAVLLTRSEEGMTLFSEG 249 Query: 245 EVTHFPTMAREVFDVSGAGDTVIGTLAVMLGAGASLVEAVTMANRAGGIVVGKLGTATVT 304 E + PT A+EV+DVSGAGDTVI + + L AG ++ EA+ +AN A G+VV KLGTA + Sbjct: 250 EPIYQPTRAQEVYDVSGAGDTVIAGMGLGLAAGCTMPEAMYLANTAAGVVVAKLGTAVCS 309 Query: 305 REELL 309 EL+ Sbjct: 310 FAELI 314 >NMA1034 [M] COG2870 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase NmA Neisseria meningitidis Z2491 Length = 323 Score = 361 bits (926), Expect = 1e-99, Method: Compositional matrix adjust. Identities = 171/304 (56%), Positives = 231/304 (75%) Query: 5 LLSAWSNARILVVGDVMLDRYWFGEVNRISPEAPVPVVRVERKEERLGGAANVARNIASL 64 L S ++ A++LVVGDVMLDRYWFG+V+RISPEAPVPV ++ R ++R GGAANVARNIASL Sbjct: 10 LKSRFAQAKVLVVGDVMLDRYWFGDVSRISPEAPVPVAKIGRIDQRAGGAANVARNIASL 69 Query: 65 GAQTALLGVTGDDEPARVMDAMLREMGIASHLNRDPSISTIVKLRVIGRQQQLVRIDFEE 124 G + LL VTG+DE A +DA++ + G+AS+L RD I+T VKLRV+ R QQL+R+DFEE Sbjct: 70 GGKVGLLSVTGNDEAADALDALMVQDGVASYLMRDKQIATTVKLRVVARNQQLIRLDFEE 129 Query: 125 APTDTVLRDKLTQFNTLVADYDVILFSDYAKGSLVNVAEMIATARKLGKRILVDPKGDDF 184 P VL ++ ++ +YD I+FSDY KG L ++++MI A+ GK +L+DPKGDD+ Sbjct: 130 HPNREVLEQIKRKYREILPEYDAIIFSDYGKGGLSHISDMIDWAKHEGKTVLIDPKGDDY 189 Query: 185 QRYVGASLLTPNKSELVRIVGQWKNEDDLTARAQKLRAELQLEALLLTRSEEGMSLYRDG 244 ++Y GA+L+TPN++EL +VG WKNE+DLT +AQ LR L L A+LLTRSEEGM+L+ +G Sbjct: 190 EKYAGATLITPNRAELKEVVGSWKNENDLTEKAQNLRRHLDLTAILLTRSEEGMTLFSEG 249 Query: 245 EVTHFPTMAREVFDVSGAGDTVIGTLAVMLGAGASLVEAVTMANRAGGIVVGKLGTATVT 304 E + PT A+EV+DVSGAGDTVI + + L AG ++ EA+ +AN A G+VV KLGTA + Sbjct: 250 EPIYQPTRAQEVYDVSGAGDTVIAGMGLGLAAGCTMPEAMYLANTAAGVVVAKLGTAVCS 309 Query: 305 REEL 308 EL Sbjct: 310 FAEL 313 >rfaE [M] COG2870 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Eco Escherichia coli K12 Length = 477 Score = 307 bits (786), Expect = 2e-83, Method: Compositional matrix adjust. Identities = 162/307 (52%), Positives = 209/307 (68%), Gaps = 1/307 (0%) Query: 3 KDLLSAWSNARILVVGDVMLDRYWFGEVNRISPEAPVPVVRVERKEERLGGAANVARNIA 62 K L + A ++VVGDVMLDRYW+G +RISPEAPVPVV+V EER GGAANVA NIA Sbjct: 2 KVTLPEFERAGVMVVGDVMLDRYWYGPTSRISPEAPVPVVKVNTIEERPGGAANVAMNIA 61 Query: 63 SLGAQTALLGVTGDDEPARVMDAMLREMGIASHLNRDPSISTIVKLRVIGRQQQLVRIDF 122 SLGA L+G+TG D+ AR + L ++ + P+ TI KLRV+ R QQL+R+DF Sbjct: 62 SLGANARLVGLTGIDDAARALSKSLADVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDF 121 Query: 123 EEAPTDTVLRDKLTQFNTLVADYDVILFSDYAKGSLVNVAEMIATARKLGKRILVDPKGD 182 EE + + N ++ ++ SDYAKG+L +V +MI ARK G +L+DPKG Sbjct: 122 EEGFEGVDPQPLHERINQALSSIGALVLSDYAKGALASVQQMIQLARKAGVPVLIDPKGT 181 Query: 183 DFQRYVGASLLTPNKSELVRIVGQWKNEDDLTARAQKLRAELQLEALLLTRSEEGMSLYR 242 DF+RY GA+LLTPN SE +VG+ K E+++ R KL A+ +L ALL+TRSE+GMSL + Sbjct: 182 DFERYRGATLLTPNLSEFEAVVGKCKTEEEIVERGMKLIADYELSALLVTRSEQGMSLLQ 241 Query: 243 DGEVT-HFPTMAREVFDVSGAGDTVIGTLAVMLGAGASLVEAVTMANRAGGIVVGKLGTA 301 G+ H PT A+EV+DV+GAGDTVIG LA L AG SL EA AN A G+VVGKLGT+ Sbjct: 242 PGKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNSLEEACFFANAAAGVVVGKLGTS 301 Query: 302 TVTREEL 308 TV+ EL Sbjct: 302 TVSPIEL 308 >Z4405 [M] COG2870 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase EcZ Escherichia coli O157:H7 EDL933 Length = 477 Score = 306 bits (784), Expect = 4e-83, Method: Compositional matrix adjust. Identities = 162/307 (52%), Positives = 209/307 (68%), Gaps = 1/307 (0%) Query: 3 KDLLSAWSNARILVVGDVMLDRYWFGEVNRISPEAPVPVVRVERKEERLGGAANVARNIA 62 K L + A ++VVGDVMLDRYW+G +RISPEAPVPVV+V EER GGAANVA NIA Sbjct: 2 KVTLPEFERAGVMVVGDVMLDRYWYGPSSRISPEAPVPVVKVNTIEERPGGAANVAMNIA 61 Query: 63 SLGAQTALLGVTGDDEPARVMDAMLREMGIASHLNRDPSISTIVKLRVIGRQQQLVRIDF 122 SLGA L+G+TG D+ AR + L ++ + P+ TI KLRV+ R QQL+R+DF Sbjct: 62 SLGANARLVGLTGIDDAARALSKSLADVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDF 121 Query: 123 EEAPTDTVLRDKLTQFNTLVADYDVILFSDYAKGSLVNVAEMIATARKLGKRILVDPKGD 182 EE + + N ++ ++ SDYAKG+L +V +MI ARK G +L+DPKG Sbjct: 122 EEGFEGVDPQPLHERINQALSSIGALVLSDYAKGALASVQQMIQLARKAGVPVLIDPKGT 181 Query: 183 DFQRYVGASLLTPNKSELVRIVGQWKNEDDLTARAQKLRAELQLEALLLTRSEEGMSLYR 242 DF+RY GA+LLTPN SE +VG+ K E+++ R KL A+ +L ALL+TRSE+GMSL + Sbjct: 182 DFERYRGATLLTPNLSEFEAVVGKCKTEEEIVERGMKLIADYELSALLVTRSEQGMSLLQ 241 Query: 243 DGEVT-HFPTMAREVFDVSGAGDTVIGTLAVMLGAGASLVEAVTMANRAGGIVVGKLGTA 301 G+ H PT A+EV+DV+GAGDTVIG LA L AG SL EA AN A G+VVGKLGT+ Sbjct: 242 PGKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNSLEEACFFANAAAGVVVGKLGTS 301 Query: 302 TVTREEL 308 TV+ EL Sbjct: 302 TVSPIEL 308