BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0005.0466.p (505 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PM1716 [L] COG0272 NAD-dependent DNA ligase (contains BRCT domai... 560 e-159 VC0971 [L] COG0272 NAD-dependent DNA ligase (contains BRCT domai... 559 e-159 HI1100 [L] COG0272 NAD-dependent DNA ligase (contains BRCT domai... 558 e-158 ECs3283 [L] COG0272 NAD-dependent DNA ligase (contains BRCT doma... 540 e-153 YPO2989 [L] COG0272 NAD-dependent DNA ligase (contains BRCT doma... 539 e-153 >PM1716 [L] COG0272 NAD-dependent DNA ligase (contains BRCT domain type II) Pmu Pasteurella multocida Length = 673 Score = 560 bits (1443), Expect = e-159, Method: Compositional matrix adjust. Identities = 285/497 (57%), Positives = 355/497 (71%), Gaps = 1/497 (0%) Query: 1 VRGEVLMYKDDFARLNQRQRDAGQKEFANPRNAAAGSLRQLDSRITAQRTLRFFAYGIGV 60 VRGEV M + F LN++ G+K FANPRNAAAGSLRQLD RIT+QR L AY IGV Sbjct: 172 VRGEVFMSQAGFEVLNEKALARGEKTFANPRNAAAGSLRQLDPRITSQRPLLLNAYSIGV 231 Query: 61 LEGADMPSSHSALLDWYQQLGLPVCKERAVVTGATGLLEFFRGIGAKRESLPYEIDGVVY 120 EG D+P +H L W + +G+PV E + G +L F+R I KR +L Y+IDG V Sbjct: 232 AEGIDLPDTHFERLQWLKSIGIPVNNEIQLCEGTENVLNFYRAIMQKRSTLGYDIDGTVI 291 Query: 121 KVDRLDQQKQLGFVSRAPRFALAHKFPAQEALTVVQDIEVQVGRTGAITPVARLNPVFVG 180 KV+ + Q++LGF+S+APR+A+A+KFPAQE LTV+ +E QVGRTGAITPVA+L PVFV Sbjct: 292 KVNDIALQEELGFISKAPRWAIAYKFPAQEELTVLNAVEFQVGRTGAITPVAKLQPVFVA 351 Query: 181 GVTVTNATLHNEDEVRRKDIQIGDTVIVRRAGDVIPEVVAYVPEKRPADARAFVMPAACP 240 GVTV+NATLHN DE+ R D+ IGDTVI+RRAGDVIP+++ + EKRPA+A V P CP Sbjct: 352 GVTVSNATLHNGDEIARLDVAIGDTVIIRRAGDVIPQIIGVLHEKRPANAEKIVFPTECP 411 Query: 241 VCGSPIVRAEDEAVARCSGGWLKCSAQRKGGLQHFASRRAMDIEGLGEQLVEQLVDRKVV 300 VCGS IVR E EAVARC+GG L C+AQRK L+HF SR+AMDI+G+G +L+EQLVDR+ + Sbjct: 412 VCGSVIVRIEGEAVARCTGG-LFCAAQRKEALKHFVSRKAMDIDGVGAKLIEQLVDREQI 470 Query: 301 NTPADLYRLGLSALAELDRMAEKSAQNVLDALQKSKSTTLARFIYALGIRHVGEATAKEL 360 +TPADL++L L+ LA L+RM KSAQN LD+LQK+K TTLARFI+ALGIR VGEATA L Sbjct: 471 HTPADLFKLDLNTLARLERMGLKSAQNALDSLQKAKKTTLARFIFALGIREVGEATALNL 530 Query: 361 ARHFGGLDKILAASEAQLLEVADVGPVVATSIRSFFDDALNVELVEQLRAVGVHWPESAG 420 A HF L+ + A+ QL EV DVG VVA I F+ + NV +VE L A G+HW Sbjct: 531 ANHFKTLEALKEATLEQLQEVQDVGEVVANRIFVFWREPHNVAVVEDLIAQGIHWETVEV 590 Query: 421 VEAAAKHLAGKTFVLTGTLPNLSRDEASQLIEAAGGKVTGSVSKKTTYVVAGAEAGSKLA 480 + KT VLTGTL + R EA L++ G KV+GSVS KT VVAG AGSKL Sbjct: 591 KDVGDNPFKEKTVVLTGTLTQMGRTEAKALLQQLGAKVSGSVSAKTDLVVAGDSAGSKLT 650 Query: 481 KAEELGIAILDEDGLKA 497 KA ELG+ ++DE+ A Sbjct: 651 KANELGVKVIDENTFLA 667 >VC0971 [L] COG0272 NAD-dependent DNA ligase (contains BRCT domain type II) Vch Vibrio cholerae Length = 669 Score = 559 bits (1440), Expect = e-159, Method: Compositional matrix adjust. Identities = 284/496 (57%), Positives = 361/496 (72%), Gaps = 2/496 (0%) Query: 1 VRGEVLMYKDDFARLNQRQRDAGQKEFANPRNAAAGSLRQLDSRITAQRTLRFFAYGIGV 60 VRGEV M K F LN R G+K+F NPRNAAAGSLRQLDS+ITAQR L F+AY +GV Sbjct: 170 VRGEVFMPKAGFEALNARALKKGEKQFVNPRNAAAGSLRQLDSKITAQRPLAFYAYSVGV 229 Query: 61 LEGADMPSSHSALLDWYQQLGLPVCKERAVVTGATGLLEFFRGIGAKRESLPYEIDGVVY 120 +EG ++ +SH + GLP+C E +VT + F++ I +R+SL YEIDGVV Sbjct: 230 IEGGELATSHYQRFLQLKGWGLPICPETKLVTSLAEVKAFYQDILQRRQSLAYEIDGVVI 289 Query: 121 KVDRLDQQKQLGFVSRAPRFALAHKFPAQEALTVVQDIEVQVGRTGAITPVARLNPVFVG 180 KVD + Q++LGFV+RAPR+A+A+KFPAQE LT++ D+E QVGRTGAITPVA+L PVFVG Sbjct: 290 KVDDIQLQERLGFVARAPRWAIAYKFPAQEELTLLNDVEFQVGRTGAITPVAKLEPVFVG 349 Query: 181 GVTVTNATLHNEDEVRRKDIQIGDTVIVRRAGDVIPEVVAYVPEKRPADARAFVMPAACP 240 GVTV+NATLHN DE+ R + +GDTV++RRAGDVIP++V+ V E+RP +A++ V P CP Sbjct: 350 GVTVSNATLHNADEIERLGVMVGDTVVIRRAGDVIPQIVSVVLERRPENAKSIVFPTRCP 409 Query: 241 VCGSPIVRAEDEAVARCSGGWLKCSAQRKGGLQHFASRRAMDIEGLGEQLVEQLVDRKVV 300 VC S + R E EAVARCSGG L C AQRK L+HF SR+AMD+EGLG++++EQLVDR++V Sbjct: 410 VCQSDVERVEGEAVARCSGG-LICQAQRKEALKHFVSRKAMDVEGLGDKVIEQLVDREMV 468 Query: 301 NTPADLYRLGLSALAELDRMAEKSAQNVLDALQKSKSTTLARFIYALGIRHVGEATAKEL 360 +TPADL+RL L L+RM KSAQNV+DAL K+K TTL +F+YALGIR VGEATA L Sbjct: 469 STPADLFRLRAGELTILERMGPKSAQNVIDALNKAKQTTLPKFLYALGIREVGEATALNL 528 Query: 361 ARHFGGLDKILAASEAQLLEVADVGPVVATSIRSFFDDALNVELVEQLRAVGVHWPE-SA 419 A+HF L+ I AS Q +EV DVG VVA+ +++FF N +++ +L G+ WP +A Sbjct: 529 AQHFLSLEAIQQASLEQFIEVPDVGVVVASHLQAFFAQDRNQQVINELLEQGITWPALTA 588 Query: 420 GVEAAAKHLAGKTFVLTGTLPNLSRDEASQLIEAAGGKVTGSVSKKTTYVVAGAEAGSKL 479 A LAGK VLTG+ LSR++A ++A G KVTGSVSK T V AG AGSKL Sbjct: 589 APVAVDSALAGKIVVLTGSFTQLSRNDAKAALQALGAKVTGSVSKNTDMVFAGEAAGSKL 648 Query: 480 AKAEELGIAILDEDGL 495 AKA ELGI + DE L Sbjct: 649 AKATELGIQVFDEQAL 664 >HI1100 [L] COG0272 NAD-dependent DNA ligase (contains BRCT domain type II) Hin Haemophilus influenzae Length = 679 Score = 558 bits (1438), Expect = e-158, Method: Compositional matrix adjust. Identities = 278/497 (55%), Positives = 361/497 (72%), Gaps = 1/497 (0%) Query: 1 VRGEVLMYKDDFARLNQRQRDAGQKEFANPRNAAAGSLRQLDSRITAQRTLRFFAYGIGV 60 VRGEV M F RLN+ + +K FANPRNAAAGSLRQLD IT++R L AYGIG+ Sbjct: 180 VRGEVFMPHAGFERLNKYALEHNEKTFANPRNAAAGSLRQLDPNITSKRPLVLNAYGIGI 239 Query: 61 LEGADMPSSHSALLDWYQQLGLPVCKERAVVTGATGLLEFFRGIGAKRESLPYEIDGVVY 120 EG D+P++H A L W + +G+PV E + GA +L F+R I KR SL Y+IDG V Sbjct: 240 AEGVDLPTTHYARLQWLKSIGIPVNPEIRLCNGADEVLGFYRDIQNKRSSLGYDIDGTVL 299 Query: 121 KVDRLDQQKQLGFVSRAPRFALAHKFPAQEALTVVQDIEVQVGRTGAITPVARLNPVFVG 180 K++ + Q +LGF+S+APR+A+A+KFPAQE LT++ D+E QVGRTGAITPVA+L PVFV Sbjct: 300 KINDIALQNELGFISKAPRWAIAYKFPAQEELTLLNDVEFQVGRTGAITPVAKLEPVFVA 359 Query: 181 GVTVTNATLHNEDEVRRKDIQIGDTVIVRRAGDVIPEVVAYVPEKRPADARAFVMPAACP 240 GVTV+NATLHN DE+ R +I IGDTV++RRAGDVIP+++ + E+RP +A+ + P CP Sbjct: 360 GVTVSNATLHNGDEIERLNIAIGDTVVIRRAGDVIPQIIGVLHERRPDNAKPIIFPTNCP 419 Query: 241 VCGSPIVRAEDEAVARCSGGWLKCSAQRKGGLQHFASRRAMDIEGLGEQLVEQLVDRKVV 300 VC S I+R E EAVARC+GG L C+AQRK L+HF SR+AMDI+G+G +L+EQLVDR+++ Sbjct: 420 VCDSQIIRIEGEAVARCTGG-LFCAAQRKEALKHFVSRKAMDIDGVGGKLIEQLVDRELI 478 Query: 301 NTPADLYRLGLSALAELDRMAEKSAQNVLDALQKSKSTTLARFIYALGIRHVGEATAKEL 360 +TPADL++L L+ L L+RM KSA+N L++L+ +KSTTLARFI+ALGIR VGEATA L Sbjct: 479 HTPADLFKLDLTTLTRLERMGAKSAENALNSLENAKSTTLARFIFALGIREVGEATALNL 538 Query: 361 ARHFGGLDKILAASEAQLLEVADVGPVVATSIRSFFDDALNVELVEQLRAVGVHWPESAG 420 A HF LD + A+ +L +V DVG VVA I F+ +A NV +VE L A GVHW Sbjct: 539 ANHFKTLDALKDANLEELQQVPDVGEVVANRIFIFWREAHNVAVVEDLIAQGVHWETVEV 598 Query: 421 VEAAAKHLAGKTFVLTGTLPNLSRDEASQLIEAAGGKVTGSVSKKTTYVVAGAEAGSKLA 480 EA+ KT VLTGTL + R+EA L++ G KV+GSVS KT +V+AG AGSKLA Sbjct: 599 KEASENLFKDKTVVLTGTLTQMGRNEAKALLQQLGAKVSGSVSSKTDFVIAGDAAGSKLA 658 Query: 481 KAEELGIAILDEDGLKA 497 KA+EL I +L E+ A Sbjct: 659 KAQELNITVLTEEEFLA 675 >ECs3283 [L] COG0272 NAD-dependent DNA ligase (contains BRCT domain type II) Ecs Escherichia coli O157:H7 Length = 671 Score = 540 bits (1392), Expect = e-153, Method: Compositional matrix adjust. Identities = 275/494 (55%), Positives = 356/494 (72%), Gaps = 3/494 (0%) Query: 1 VRGEVLMYKDDFARLNQRQRDAGQKEFANPRNAAAGSLRQLDSRITAQRTLRFFAYGIGV 60 VRGEV + + F ++N+ R G K FANPRNAAAGSLRQLD RITA+R L FF YG+GV Sbjct: 170 VRGEVFLPQAGFEKINEDARRTGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGV 229 Query: 61 LEGADMPSSHSALLDWYQQLGLPVCKERAVVTGATGLLEFFRGIGAKRESLPYEIDGVVY 120 LEG ++P +H L +++ GLPV + A +L F+ + R +L ++IDGVV Sbjct: 230 LEGGELPDTHLGRLLQFKKWGLPVSDRVTLCESAEEVLAFYHKVEEDRPTLGFDIDGVVI 289 Query: 121 KVDRLDQQKQLGFVSRAPRFALAHKFPAQEALTVVQDIEVQVGRTGAITPVARLNPVFVG 180 KV+ L+QQ+QLGFV+RAPR+A+A KFPAQE +T V+D+E QVGRTGAITPVARL PV V Sbjct: 290 KVNSLEQQEQLGFVARAPRWAVAFKFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVHVA 349 Query: 181 GVTVTNATLHNEDEVRRKDIQIGDTVIVRRAGDVIPEVVAYVPEKRPADARAFVMPAACP 240 GV V+NATLHN DE+ R ++IGD V++RRAGDVIP+VV V +RP D R V P CP Sbjct: 350 GVLVSNATLHNADEIERLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEDTREVVFPTYCP 409 Query: 241 VCGSPIVRAEDEAVARCSGGWLKCSAQRKGGLQHFASRRAMDIEGLGEQLVEQLVDRKVV 300 VCGS + R E EAVARC+GG L C AQRK L+HF SRRAMD++G+G+++++QLV+++ V Sbjct: 410 VCGSDVERVEGEAVARCTGG-LICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLVEKEYV 468 Query: 301 NTPADLYRLGLSALAELDRMAEKSAQNVLDALQKSKSTTLARFIYALGIRHVGEATAKEL 360 +TPADL++L L L+RM KSAQNV++AL+K+K TT ARF+YALGIR VGEATA L Sbjct: 469 HTPADLFKLTAGKLTGLERMGPKSAQNVVNALEKAKETTFARFLYALGIREVGEATAAGL 528 Query: 361 ARHFGGLDKILAASEAQLLEVADVGPVVATSIRSFFDDALNVELVEQLRAVGVHWPESAG 420 A +FG L+ + AAS +L +V DVG VVA+ + +FF + N ++ +L A GVHWP Sbjct: 529 AAYFGTLEALEAASIEELQKVPDVGIVVASHVHNFFAEESNRNVISELLAEGVHWPAPIV 588 Query: 421 VEAAA--KHLAGKTFVLTGTLPNLSRDEASQLIEAAGGKVTGSVSKKTTYVVAGAEAGSK 478 + A AGKT VLTG+L +SRD+A + G KV GSVSKKT V+AG AGSK Sbjct: 589 INAEEIDSPFAGKTVVLTGSLSQMSRDDAKARLVELGAKVAGSVSKKTDLVIAGEAAGSK 648 Query: 479 LAKAEELGIAILDE 492 LAKA+ELGI ++DE Sbjct: 649 LAKAQELGIEVIDE 662 >YPO2989 [L] COG0272 NAD-dependent DNA ligase (contains BRCT domain type II) Ype Yersinia pestis Length = 670 Score = 539 bits (1388), Expect = e-153, Method: Compositional matrix adjust. Identities = 284/503 (56%), Positives = 356/503 (70%), Gaps = 4/503 (0%) Query: 1 VRGEVLMYKDDFARLNQRQRDAGQKEFANPRNAAAGSLRQLDSRITAQRTLRFFAYGIGV 60 VRGEV M + F +LN+ R G K FANPRNAAAGSLRQLD RITA+R L FF YG+G+ Sbjct: 170 VRGEVFMPQAGFEQLNEEARRKGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGL 229 Query: 61 LEGADMPSSHSALLDWYQQLGLPVCKERAVVTGATGLLEFFRGIGAKRESLPYEIDGVVY 120 L+G ++P SH L ++ GLPV + + TG+ ++ F+R I R L ++IDGVV Sbjct: 230 LDGGELPRSHIQCLMQFKAWGLPVSERVKLCTGSDQVIAFYRQIEQDRAGLGFDIDGVVI 289 Query: 121 KVDRLDQQKQLGFVSRAPRFALAHKFPAQEALTVVQDIEVQVGRTGAITPVARLNPVFVG 180 KVD L Q+QLGFV+RAPR+A A KFPAQE +T V+++E QVGRTGAITPVARL PV V Sbjct: 290 KVDDLALQEQLGFVARAPRWATAFKFPAQEQITQVREVEFQVGRTGAITPVARLEPVQVA 349 Query: 181 GVTVTNATLHNEDEVRRKDIQIGDTVIVRRAGDVIPEVVAYVPEKRPADARAFVMPAACP 240 GV V+NATLHN DE+ R ++IGDTVIVRRAGDVIP+VV V E+RP D + P+ CP Sbjct: 350 GVIVSNATLHNADEIERLGLRIGDTVIVRRAGDVIPQVVGVVMEQRPDDTKEITFPSQCP 409 Query: 241 VCGSPIVRAEDEAVARCSGGWLKCSAQRKGGLQHFASRRAMDIEGLGEQLVEQLVDRKVV 300 VCGS I R E EAVARC+GG L C+AQRK L+HF SRRA+D++G+G++++EQLV+++ V Sbjct: 410 VCGSDIERVEGEAVARCTGG-LFCAAQRKEALKHFVSRRALDVDGMGDKIIEQLVEKQYV 468 Query: 301 NTPADLYRLGLSALAELDRMAEKSAQNVLDALQKSKSTTLARFIYALGIRHVGEATAKEL 360 PADL++L L LDRM KSAQN++ AL+K+K TT ARF+YALGIR VGEATA L Sbjct: 469 ENPADLFQLTAGKLTGLDRMGPKSAQNLIAALEKAKQTTFARFLYALGIREVGEATAANL 528 Query: 361 ARHFGGLDKILAASEAQLLEVADVGPVVATSIRSFFDDALNVELVEQLRAVGVHWPESAG 420 A HF LD + AA L V DVG VVA + +F + N +++E+L V V WPE Sbjct: 529 AAHFRTLDNLRAADIETLKSVPDVGEVVAKHVMNFLSEEHNQKVIEELEKV-VSWPEPQQ 587 Query: 421 --VEAAAKHLAGKTFVLTGTLPNLSRDEASQLIEAAGGKVTGSVSKKTTYVVAGAEAGSK 478 VE + AGKT VLTG+L LSRDEA + A G KV+GSVSKKT V+AG AGSK Sbjct: 588 IVVEESDSPFAGKTVVLTGSLTILSRDEAKDRLTALGAKVSGSVSKKTHLVIAGEAAGSK 647 Query: 479 LAKAEELGIAILDEDGLKALCAE 501 LAKA+ELGI ++DE + L E Sbjct: 648 LAKAQELGIKVIDEAEMIRLLGE 670