BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0005.0442.p (423 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1370 [GEPR] COG0477 Permeases of the major facilitator superf... 547 e-155 YPO0792 [GEPR] COG0477 Permeases of the major facilitator superf... 265 1e-70 ZygeD [GEPR] COG0477 Permeases of the major facilitator superfam... 254 4e-67 ECs3692 [GEPR] COG0477 Permeases of the major facilitator superf... 254 4e-67 ygeD [GEPR] COG0477 Permeases of the major facilitator superfami... 254 4e-67 >RSc1370 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 438 Score = 547 bits (1410), Expect = e-155, Method: Compositional matrix adjust. Identities = 303/438 (69%), Positives = 355/438 (81%), Gaps = 19/438 (4%) Query: 1 MNRGFYTIMAAQFFSSLADNALLIAAIALLAEMHSPAWMTPLLKLFFVLSYVLLAAFVGA 60 M +GFYTIMAAQFFSSLADNALLIAAIALL EMHSP WMTPLLKLFFVLSYVLLAAFVGA Sbjct: 1 MKKGFYTIMAAQFFSSLADNALLIAAIALLTEMHSPQWMTPLLKLFFVLSYVLLAAFVGA 60 Query: 61 FADAFPKGKVMLITNMIKIVGCSLMFFTVHPLLAYAVVGFGAAAYSPAKYGILTELLPPE 120 FAD+ PKG+VMLITN IK+ GC +M +HPLLAY VVGFGAAAYSPAKYG+LTELLPPE Sbjct: 61 FADSMPKGRVMLITNAIKLAGCGVMLTGLHPLLAYGVVGFGAAAYSPAKYGLLTELLPPE 120 Query: 121 KLVAANGWIEGLTVGSIIMGTVLGGALVNPKISSVILSFDFPLVDLPIDTPTEAALCIIS 180 KLVAANGWIEGLTVGSII+GTVLGGAL++ IS+ +LS D P ++ IDTP EAA+ +I Sbjct: 121 KLVAANGWIEGLTVGSIILGTVLGGALISKHISTWLLSIDVPGLE-AIDTPAEAAMIVIM 179 Query: 181 LIYVIAALFNFNIPDTGARYEHQERNPIRLIVDFAGCFTTLWKDKLGQISLAVTTLFWGA 240 +IY++AALFN IPDTGARY QE+NP+RLI +FA CF LW+DKLGQISLAVTTLFWGA Sbjct: 180 VIYLVAALFNLRIPDTGARYPQQEKNPVRLIAEFADCFNALWRDKLGQISLAVTTLFWGA 239 Query: 241 GATLQFIVLKWAEKSLHMPLDKAAILQGIVAVGVALGAMAAARFVPLKKSLTVMPLGIVM 300 GATLQFIVLKWAE+SL + L + AILQ +VAVGVA GAMAAA VPL++SL V+P+G+ M Sbjct: 240 GATLQFIVLKWAERSLELNLSQGAILQAVVAVGVAAGAMAAAVKVPLRRSLDVLPVGVAM 299 Query: 301 GIVVMLMTTTTS------------------VWVAYPLLVIVGALSGYFVVPMNALLQHRG 342 G +VMLM T + +AY L++VGA+SG+FVVPMNALLQHRG Sbjct: 300 GALVMLMAFYTKHTIPDVTFHIGHMKLPLYMLIAYLFLMMVGAMSGFFVVPMNALLQHRG 359 Query: 343 HVLMSAGHSIAVQNFNENLSVLTMLVLYAFMVRMNLDVNTVIIIFGSFVAGIMYLIMRRH 402 HVL+SAGHSIAVQNFNEN+SVL ML LYA ++++++ V VI+ FG FV M L+MRRH Sbjct: 360 HVLLSAGHSIAVQNFNENVSVLLMLCLYALLIKLDVPVGVVIVAFGVFVCVTMALVMRRH 419 Query: 403 AANQREHDSLALIGEDKH 420 N+R + + ALIGEDKH Sbjct: 420 RRNERVYHTAALIGEDKH 437 >YPO0792 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 406 Score = 265 bits (677), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 158/379 (41%), Positives = 235/379 (62%), Gaps = 23/379 (6%) Query: 1 MNRGFYTIMAAQFFSSLADNALLIAAIALLAEMHSPAWMTPLLKLFFVLSYVLLAAFVGA 60 ++R ++ AQFFS+ DNALL A +AL+ + P W P+L++ FV +Y++LA FVG Sbjct: 12 LSRSMVAVLCAQFFSAFGDNALLFATLALIKQQLYPDWSQPILQMAFVATYIVLAPFVGQ 71 Query: 61 FADAFPKGKVMLITNMIKIVGCSLMFFTVHPLLAYAVVGFGAAAYSPAKYGILTELLPPE 120 AD F KG+VM++ N +K+ G ++ F ++P L Y++VG GAAAYSPAKYGIL E+ E Sbjct: 72 IADGFAKGRVMMVANGLKLAGALVICFGLNPFLGYSLVGVGAAAYSPAKYGILGEITSGE 131 Query: 121 KLVAANGWIEGLTVGSIIMGTVLGGALVNPKISSVILSFDFPLVDLPIDTPTEAALCIIS 180 +LV ANG +E T+ +I++G+V GG L D+ L+ AAL + + Sbjct: 132 QLVKANGMMEASTIAAILLGSVAGGILA-----------DWHLM---------AALGVCA 171 Query: 181 LIYVIAALFNFNIPDTGARYEHQERNPIRLIVDFAGCFTTLWKDKLGQISLAVTTLFWGA 240 L+Y IA + N IP A P + F LW+D + SLA T+LFWGA Sbjct: 172 LVYAIAVIANLFIPRLAAARSGASWRPRAMTGSFFTACRLLWQDSETRFSLAGTSLFWGA 231 Query: 241 GATLQFIVLKWAEKSLHMPLDKA--AILQGIVAVGVALGAMAAARFVPLKKSLTVMPLGI 298 G TL+F+++ W +L + D A +L +VA+G+ +GA AAARFV LK +P G+ Sbjct: 232 GVTLRFLLVLWVPVALGIA-DNATPTLLNAMVAIGIVVGAGAAARFVTLKTVKRCLPAGV 290 Query: 299 VMGIVVMLMTTTTSVWVAYPLLVIVGALSGYFVVPMNALLQHRGHVLMSAGHSIAVQNFN 358 ++G++V + + S+ +AY LL+I+G L G+FVVP+NALLQ RG + AG++IAVQN Sbjct: 291 LIGVMVTIFSLQNSMPMAYLLLIIIGILGGFFVVPLNALLQERGKHSVGAGNAIAVQNLG 350 Query: 359 ENLSVLTMLVLYAFMVRMN 377 EN ++L ML LY+ +V++ Sbjct: 351 ENTAMLFMLGLYSLVVKLG 369 >ZygeD [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 397 Score = 254 bits (648), Expect = 4e-67, Method: Compositional matrix adjust. Identities = 162/406 (39%), Positives = 235/406 (57%), Gaps = 26/406 (6%) Query: 2 NRGFYTIMAAQFFSSLADNALLIAAIALLAEMHSPAWMTPLLKLFFVLSYVLLAAFVGAF 61 ++G ++ AQF S+ DNALL A +ALL P W P+L++ FV +Y+L A FVG Sbjct: 13 SKGMKAVIVAQFLSAFGDNALLFATLALLKAQFYPEWSQPILQMVFVGAYILFAPFVGQV 72 Query: 62 ADAFPKGKVMLITNMIKIVGCSLMFFTVHPLLAYAVVGFGAAAYSPAKYGILTELLPPEK 121 AD+F KG+VM+ N +K++G + + F ++P L Y +VG GAAAYSPAKYGIL EL K Sbjct: 73 ADSFAKGRVMMFANGLKLLGAASICFGINPFLGYTLVGVGAAAYSPAKYGILGELTTGSK 132 Query: 122 LVAANGWIEGLTVGSIIMGTVLGGALVNPKISSVILSFDFPLVDLPIDTPTEAALCIISL 181 LV ANG +E T+ +I++G+V GG L D AL +L Sbjct: 133 LVKANGLMEASTIAAILLGSVAGGVLA--------------------DWHVLVALAACAL 172 Query: 182 IYVIAALFNFNIPDTGARYEHQERNPIRLIVDFAGCFTTLWKDKLGQISLAVTTLFWGAG 241 Y A + N IP A Q N I + F T+LW++ + SL T+LFWGAG Sbjct: 173 AYGGAVVANIYIPKLAAARPGQSWNLINMTRSFLNACTSLWRNGETRFSLVGTSLFWGAG 232 Query: 242 ATLQFIVLKWAEKSLHMPLDKA--AILQGIVAVGVALGAMAAARFVPLKKSLTVMPLGIV 299 TL+F+++ W +L + D A L +VA+G+ +GA AAA+ V L+ MP GI+ Sbjct: 233 VTLRFLLVLWVPVALGIT-DNATPTYLNAMVAIGIVVGAGAAAKLVTLETVSRCMPAGIL 291 Query: 300 MGIVVMLMTTTTSVWVAYPLLVIVGALSGYFVVPMNALLQHRGHVLMSAGHSIAVQNFNE 359 +G+VV++ + AY LL+++G L G+FVVP+NALLQ RG + AG++IAVQN E Sbjct: 292 IGVVVLIFSLQHEQLPAYALLMLIGVLGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGE 351 Query: 360 NLSVLTMLVLYAFMVRMNLDVNTVIIIFGSFVA---GIMYLIMRRH 402 N ++L ML +Y+ V + + V + I FG+ A +++ RRH Sbjct: 352 NSAMLLMLGIYSLAVMVGIPVVPIGIGFGALFALAITALWIWQRRH 397 >ECs3692 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 397 Score = 254 bits (648), Expect = 4e-67, Method: Compositional matrix adjust. Identities = 162/406 (39%), Positives = 235/406 (57%), Gaps = 26/406 (6%) Query: 2 NRGFYTIMAAQFFSSLADNALLIAAIALLAEMHSPAWMTPLLKLFFVLSYVLLAAFVGAF 61 ++G ++ AQF S+ DNALL A +ALL P W P+L++ FV +Y+L A FVG Sbjct: 13 SKGMKAVIVAQFLSAFGDNALLFATLALLKAQFYPEWSQPILQMVFVGAYILFAPFVGQV 72 Query: 62 ADAFPKGKVMLITNMIKIVGCSLMFFTVHPLLAYAVVGFGAAAYSPAKYGILTELLPPEK 121 AD+F KG+VM+ N +K++G + + F ++P L Y +VG GAAAYSPAKYGIL EL K Sbjct: 73 ADSFAKGRVMMFANGLKLLGAASICFGINPFLGYTLVGVGAAAYSPAKYGILGELTTGSK 132 Query: 122 LVAANGWIEGLTVGSIIMGTVLGGALVNPKISSVILSFDFPLVDLPIDTPTEAALCIISL 181 LV ANG +E T+ +I++G+V GG L D AL +L Sbjct: 133 LVKANGLMEASTIAAILLGSVAGGVLA--------------------DWHVLVALAACAL 172 Query: 182 IYVIAALFNFNIPDTGARYEHQERNPIRLIVDFAGCFTTLWKDKLGQISLAVTTLFWGAG 241 Y A + N IP A Q N I + F T+LW++ + SL T+LFWGAG Sbjct: 173 AYGGAVVANIYIPKLAAARPGQSWNLINMTRSFLNACTSLWRNGETRFSLVGTSLFWGAG 232 Query: 242 ATLQFIVLKWAEKSLHMPLDKA--AILQGIVAVGVALGAMAAARFVPLKKSLTVMPLGIV 299 TL+F+++ W +L + D A L +VA+G+ +GA AAA+ V L+ MP GI+ Sbjct: 233 VTLRFLLVLWVPVALGIT-DNATPTYLNAMVAIGIVVGAGAAAKLVTLETVSRCMPAGIL 291 Query: 300 MGIVVMLMTTTTSVWVAYPLLVIVGALSGYFVVPMNALLQHRGHVLMSAGHSIAVQNFNE 359 +G+VV++ + AY LL+++G L G+FVVP+NALLQ RG + AG++IAVQN E Sbjct: 292 IGVVVLIFSLQHEQLPAYALLMLIGVLGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGE 351 Query: 360 NLSVLTMLVLYAFMVRMNLDVNTVIIIFGSFVA---GIMYLIMRRH 402 N ++L ML +Y+ V + + V + I FG+ A +++ RRH Sbjct: 352 NSAMLLMLGIYSLAVMVGIPVVPIGIGFGALFALAITALWIWQRRH 397 >ygeD [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 397 Score = 254 bits (648), Expect = 4e-67, Method: Compositional matrix adjust. Identities = 161/406 (39%), Positives = 236/406 (58%), Gaps = 26/406 (6%) Query: 2 NRGFYTIMAAQFFSSLADNALLIAAIALLAEMHSPAWMTPLLKLFFVLSYVLLAAFVGAF 61 ++G ++ AQF S+ DNALL A +ALL P W P+L++ FV +Y+L A FVG Sbjct: 13 SKGMKAVIVAQFLSAFGDNALLFATLALLKAQFYPEWSQPILQMVFVGAYILFAPFVGQV 72 Query: 62 ADAFPKGKVMLITNMIKIVGCSLMFFTVHPLLAYAVVGFGAAAYSPAKYGILTELLPPEK 121 AD+F KG+VM+ N +K++G + + F ++P L Y +VG GAAAYSPAKYGIL EL K Sbjct: 73 ADSFAKGRVMMFANGLKLLGAASICFGINPFLGYTLVGVGAAAYSPAKYGILGELTTGSK 132 Query: 122 LVAANGWIEGLTVGSIIMGTVLGGALVNPKISSVILSFDFPLVDLPIDTPTEAALCIISL 181 LV ANG +E T+ +I++G+V GG L D AL +L Sbjct: 133 LVKANGLMEASTIAAILLGSVAGGVLA--------------------DWHVLVALAACAL 172 Query: 182 IYVIAALFNFNIPDTGARYEHQERNPIRLIVDFAGCFTTLWKDKLGQISLAVTTLFWGAG 241 Y A + N IP A Q N I + F T+LW++ + SL T+LFWGAG Sbjct: 173 AYGGAVVANIYIPKLAAARPGQSWNLINMTRSFLNACTSLWRNGETRFSLVGTSLFWGAG 232 Query: 242 ATLQFIVLKWAEKSLHMPLDKA--AILQGIVAVGVALGAMAAARFVPLKKSLTVMPLGIV 299 TL+F+++ W +L + D A L +VA+G+ +GA AAA+ V L+ MP GI+ Sbjct: 233 VTLRFLLVLWVPVALGIT-DNATPTYLNAMVAIGIVVGAGAAAKLVTLETVSRCMPAGIL 291 Query: 300 MGIVVMLMTTTTSVWVAYPLLVIVGALSGYFVVPMNALLQHRGHVLMSAGHSIAVQNFNE 359 +G+VV++ + + AY LL+++G + G+FVVP+NALLQ RG + AG++IAVQN E Sbjct: 292 IGVVVLIFSLQHELLPAYALLMLIGVMGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGE 351 Query: 360 NLSVLTMLVLYAFMVRMNLDVNTVIIIFGSFVA---GIMYLIMRRH 402 N ++L ML +Y+ V + + V + I FG+ A +++ RRH Sbjct: 352 NSAMLLMLGIYSLAVMIGIPVVPIGIGFGALFALAITALWIWQRRH 397