BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0005.0296.p (290 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2199 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and relate... 233 4e-61 BS_yfjR [I] COG2084 3-hydroxyisobutyrate dehydrogenase and relat... 178 1e-44 jhp0585 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and relat... 96 7e-20 NMB1584 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and relat... 77 6e-14 NMA1773 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and relat... 77 6e-14 >PA2199 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Pae Pseudomonas aeruginosa Length = 291 Score = 233 bits (593), Expect = 4e-61, Method: Compositional matrix adjust. Identities = 118/223 (52%), Positives = 160/223 (71%) Query: 1 MLADDDATETSLLDAGALAALRPGAIHVNMATISVALALRLAGLHQARGVAYVAAPVLGR 60 MLADD A LLD+GAL RPG IH++M+T+S+ L HQ +G+A+VAAPV GR Sbjct: 62 MLADDQAIRGVLLDSGALERARPGLIHLSMSTLSLDCVEALDQAHQRQGLAFVAAPVFGR 121 Query: 61 VNVAEAGQLNILAAGEEQALAAVQPLLEVLGQKTWRLGRQPEQANAAKLAMNFMIASAIG 120 +VAEAG+LNI+ G E+A+ V+ LLE++GQKTW G+ P A A K++ NFMIASAI Sbjct: 122 TDVAEAGKLNIVVGGPEEAIEQVKALLEIMGQKTWFFGKDPRGAMAVKISGNFMIASAIE 181 Query: 121 AMSEAVALVQGYGLDKAGFIELATSTAFAAPVYKGYGQAIADERFEPAGFKLALGLKDVR 180 +M E+VALV+ G++ F+EL +ST F APVY+ YG I ++RF PA F+L LGLKDV Sbjct: 182 SMGESVALVKRLGVEPGRFMELMSSTLFDAPVYRNYGPQIVEQRFTPARFRLVLGLKDVD 241 Query: 181 LALEAGEQAHVPLALASALRDLHIDGLAHGEGHLDWAALSRAS 223 LAL AG++ +VPL LAS L D+ ++ +AHG+G DW AL++ + Sbjct: 242 LALSAGKRHNVPLPLASLLHDVLLEAIAHGDGESDWTALAKVA 284 >BS_yfjR [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Bsu Bacillus subtilis Length = 261 Score = 178 bits (452), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 94/223 (42%), Positives = 142/223 (63%), Gaps = 2/223 (0%) Query: 1 MLADDDATETSLL-DAGALAALRPGAIHVNMATISVALALRLAGLHQARGVAYVAAPVLG 59 MLADDD+ T + G L L IH++M+TISV + +LA H +G ++AAPVLG Sbjct: 38 MLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSEKLAAAHAEKGQFFLAAPVLG 97 Query: 60 RVNVAEAGQLNILAAGEEQALAAVQPLLEVLGQKTWRLGRQPEQANAAKLAMNFMIASAI 119 R + A L I+ AG +A A +PLL+ L Q+ + +G + + ANAAK+++NF++ S + Sbjct: 98 RPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDVGEESKTANAAKISINFLLVSML 157 Query: 120 GAMSEAVALVQGYGLDKAGFIELATSTAFAAPVYKGYGQAIADERFEPAGFKLALGLKDV 179 A+SE+ +++ YGL++ F+E+A S F +PVY+ YG +A+++FEPAGFK++LGLKD Sbjct: 158 EALSESFLMMEKYGLEQKQFLEIA-SALFGSPVYQNYGTIMAEQKFEPAGFKMSLGLKDT 216 Query: 180 RLALEAGEQAHVPLALASALRDLHIDGLAHGEGHLDWAALSRA 222 LAL A ++ L LA + G+ G G LDWAAL + Sbjct: 217 NLALAAAKRVSANLPLAELAKSHFESGIEKGFGDLDWAALIKC 259 >jhp0585 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases jHp Helicobacter pylori J99 Length = 285 Score = 96.3 bits (238), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 70/202 (34%), Positives = 110/202 (54%), Gaps = 5/202 (2%) Query: 26 IHVNMATISVALALRLAGLHQARGVAYVAAPVLGRVNVAEAGQLNILAAGEEQALAAVQP 85 I VNM+TI+ +L L + Q Y+ APV G V A+AG L ILAAG+E+ ++ ++P Sbjct: 86 IVVNMSTIAPLESLSLEKIAQKHQATYLEAPVSGSVGAAKAGALLILAAGDEEVISKLKP 145 Query: 86 LLEVLGQKTWRLGRQPEQANAAKLAMNFMIASAIGAMSEAVALVQGYGLDKAGFIELATS 145 +L LG +T+ LG+ Q AKL++N ++A A SEA+ L + G+D F+++ Sbjct: 146 VLAHLGSQTFYLGKVG-QGTGAKLSINSLLAQMGVAYSEALLLAKRLGVDAESFLQIIGQ 204 Query: 146 TAFAAPVYKGYGQAIADERFEPAGFKLALGLKDVRLAL-EAGEQAHVPLALASALRDLHI 204 + +P+++ + + PA F L L KD+RLA EAGE +P + +L+ Sbjct: 205 SGMNSPLFQAKKGMWLQDNY-PAAFSLKLMAKDIRLAKNEAGEAMKLPFLFQA--EELYS 261 Query: 205 DGLAHGEGHLDWAALSRASARG 226 G G LD AA+ +G Sbjct: 262 QAEKSGLGGLDMAAVYHYLEKG 283 >NMB1584 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Nme Neisseria meningitidis MC58 Length = 289 Score = 76.6 bits (187), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 56/166 (33%), Positives = 86/166 (51%), Gaps = 2/166 (1%) Query: 24 GAIHVNMATISVALALRLAGLHQARGVAYVAAPVLGRVNVAEAGQLNILAAGEEQALAAV 83 G I VNM+TIS L + L +A G + APV G V A G L IL G E L + Sbjct: 89 GKIIVNMSTISPTENLAVKALVEAAGGQFAEAPVSGSVGPATNGTLLILFGGSEAVLNPL 148 Query: 84 QPLLEVLGQKTWRLGRQPEQANAAKLAMNFMIASAIGAMSEAVALVQGYGLDKAGFIELA 143 Q + ++G+KT+ G + + AKL +N ++ A SEA+ + + +G+D +E Sbjct: 149 QKIFSLVGKKTFHFG-DVGKGSGAKLVLNSLLGIFGEAYSEAMLMARQFGIDTDTIVEAI 207 Query: 144 TSTAFAAPVYKGYGQAIADERFEPAGFKLALGLKDVRLALEAGEQA 189 +A +P+++ A+ F PA F L KD+ LA++ EQA Sbjct: 208 GGSAMDSPMFQTKKSLWANREFPPA-FALKHASKDLNLAVKELEQA 252 >NMA1773 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases NmA Neisseria meningitidis Z2491 Length = 289 Score = 76.6 bits (187), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 56/166 (33%), Positives = 86/166 (51%), Gaps = 2/166 (1%) Query: 24 GAIHVNMATISVALALRLAGLHQARGVAYVAAPVLGRVNVAEAGQLNILAAGEEQALAAV 83 G I VNM+TIS L + L +A G + APV G V A G L IL G E L + Sbjct: 89 GKIIVNMSTISPTENLAVKALVEAAGGQFAEAPVSGSVGPATNGTLLILFGGSEAVLNPL 148 Query: 84 QPLLEVLGQKTWRLGRQPEQANAAKLAMNFMIASAIGAMSEAVALVQGYGLDKAGFIELA 143 Q + ++G+KT+ G + + AKL +N ++ A SEA+ + + +G+D +E Sbjct: 149 QKIFSLVGKKTFHFG-DVGKGSGAKLVLNSLLGIFGEAYSEAMLMARQFGIDTDTIVEAI 207 Query: 144 TSTAFAAPVYKGYGQAIADERFEPAGFKLALGLKDVRLALEAGEQA 189 +A +P+++ A+ F PA F L KD+ LA++ EQA Sbjct: 208 GGSAMDSPMFQTKKSLWANREFPPA-FALKHASKDLNLAVKELEQA 252