BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0005.0122.p (454 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0945 [R] COG0312 Predicted Zn-dependent proteases and their i... 649 0.0 NMA1048 [R] COG0312 Predicted Zn-dependent proteases and their i... 442 e-124 NMB0839 [R] COG0312 Predicted Zn-dependent proteases and their i... 442 e-124 pmbA [R] COG0312 Predicted Zn-dependent proteases and their inac... 422 e-118 ZpmbA [R] COG0312 Predicted Zn-dependent proteases and their ina... 422 e-118 >RSc0945 [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs Rso Ralstonia solanacearum Length = 457 Score = 649 bits (1675), Expect = 0.0, Method: Compositional matrix adjust. Identities = 335/453 (73%), Positives = 384/453 (84%), Gaps = 4/453 (0%) Query: 2 SDTPFTHSQDQLKQLAQDVLRYARDKGASDAAVDISEGSGLSVAVRKGRIETIEQNKDKG 61 +D+ F + +++L+++A+DVLR AR+ GA+DAA +ISEG GLSV VRKG IETIEQN+DK Sbjct: 9 TDSVFAYRRERLEEMARDVLRIARELGATDAATEISEGQGLSVTVRKGEIETIEQNRDKV 68 Query: 62 IGVTVFLGEGRQVRRGNASTSDFSQQALKETVEAAYNIARFTSIDDCAGLPDAEMLEMAP 121 +GVTV LG+ +RGNASTSDFS AL+ TVEAAYNIARFT+ DDCAGL + E+LE P Sbjct: 69 VGVTVMLGK----KRGNASTSDFSPAALRSTVEAAYNIARFTADDDCAGLAEEELLERQP 124 Query: 122 RDLKLFSPWNISAEEAVALAQRCETAALETDPRISNSEGAGVYVQHSHFIAANSRGFMGG 181 RDL L+ PW + AE AV +A+ E AA P+I NS+GA V QHSHF+ A SRGF+GG Sbjct: 125 RDLSLYHPWTLDAEAAVEIARAAEAAAFAVSPKIRNSDGASVSAQHSHFVLATSRGFLGG 184 Query: 182 YPFSRHTISVAPIAGKGASMQRDDWYSSKRDPKKLAQPEAIGRYAAERALARLNARKLST 241 YP+SRH IS APIAG G MQRDDWYSSKR PK LA PEAIG+YAAERALARL AR+LST Sbjct: 185 YPYSRHFISCAPIAGSGQQMQRDDWYSSKRSPKDLAAPEAIGQYAAERALARLAARRLST 244 Query: 242 RKCPVLFEAPLAAGLLGAFVQAVSGGALYRKSTFLLDSLGQQVFPEHIQILEDPHVIGGV 301 RKCPVLFEAPLAAGLLGAFVQAVSGGALYRKSTFLLDSLG+ +F H+QI EDPHV G+ Sbjct: 245 RKCPVLFEAPLAAGLLGAFVQAVSGGALYRKSTFLLDSLGKAIFAPHVQIKEDPHVPSGM 304 Query: 302 GSAPFDEEGVRTLKREVVRNGVVQGYFLSTYSARKLGMQTTGNSGGSHNLTLRSELTTRA 361 GSAPFDEEGVRT +R+VVR+GVV+GYFLSTYSARKLGMQTTGN+GGSHNLTL S+ T Sbjct: 305 GSAPFDEEGVRTQRRDVVRDGVVEGYFLSTYSARKLGMQTTGNAGGSHNLTLFSDRTQPG 364 Query: 362 DTFKGMLKKMGTGLLVTELMGQGVNYVTGDYSRGASGYWVENGVIQYPVEEITIAGNMKD 421 D F GML++MGTGLLVTELMGQGVNYVTGDYSRGASGYWVENGVIQYPVEEITIAGN++D Sbjct: 365 DDFAGMLRRMGTGLLVTELMGQGVNYVTGDYSRGASGYWVENGVIQYPVEEITIAGNLRD 424 Query: 422 MLRQIVAVGNDTLIRGTKETGSILLESMTIAGD 454 M RQIVA+G D LIRGTKETGSIL+E MTIAG+ Sbjct: 425 MFRQIVAIGADALIRGTKETGSILIEQMTIAGE 457 >NMA1048 [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs NmA Neisseria meningitidis Z2491 Length = 443 Score = 442 bits (1138), Expect = e-124, Method: Compositional matrix adjust. Identities = 224/448 (50%), Positives = 300/448 (66%), Gaps = 8/448 (1%) Query: 6 FTHSQDQLKQLAQDVLRYARDKGASDAAVDISEGSGLSVAVRKGRIETIEQNKDKGIGVT 65 F H+ +L L + L A+ GA+ A D SE G SV+VR G IE IE +DK + +T Sbjct: 3 FNHTASELLDLCRRTLDLAKATGATAAEADFSESLGQSVSVRLGEIEQIEFQQDKSLDIT 62 Query: 66 VFLGEGRQVRRGNASTSDFSQQALKETVEAAYNIARFTSIDDCAGLPDAEMLEMAPRDLK 125 V++G+ R+G A T+DFS+QAL++TV AA +IAR T+ D CAGL D E++ D Sbjct: 63 VYVGK----RKGRAGTADFSEQALRDTVRAAADIARHTAEDGCAGLADPELMAQHIGDPD 118 Query: 126 LFSPWNISAEEAVALAQRCETAALETDPRISNSEGAGVYVQHSHFIAANSRGFMGGYPFS 185 L+ W++ E AV LA++CE AAL D RI NSEGA V H ++ N+ GF + Sbjct: 119 LYHEWDLDTEAAVGLAKQCEQAALNEDERIENSEGAAVQTGHYQYVYGNTYGFAAHRQST 178 Query: 186 RHTISVAPIAGKGASMQRDDWYSSKRDPKKLAQPEAIGRYAAERALARLNARKLSTRKCP 245 H+IS + +A MQRD WY S + PE IG+ AA R L RL +R + T P Sbjct: 179 HHSISCSVVAADENGMQRDYWYDSACRHPDMDSPETIGQTAARRTLRRLGSRSIPTGNYP 238 Query: 246 VLFEAPLAAGLLGAFVQAVSGGALYRKSTFLLDSLGQQVFPEHIQILEDPHVIGGVGSAP 305 VLF+ ++ GL+G V A+SGGALYR+S+FL+DS+G++V P+ + + E+PH+ S+ Sbjct: 239 VLFDTTVSGGLIGHLVGALSGGALYRQSSFLIDSIGKKVLPDFLNLREEPHIPRSFRSSY 298 Query: 306 FDEEGVRTLKREVVRNGVVQGYFLSTYSARKLGMQTTGNSGGSHNLTLRSELTTRADTFK 365 FD EGV T R V++NG+V+GYFLS+YSARKLGMQTTGN+GG+HNL L T++D Sbjct: 299 FDAEGVATAPRFVIQNGIVEGYFLSSYSARKLGMQTTGNAGGAHNLYLNHTHETQSD--- 355 Query: 366 GMLKKMGTGLLVTELMGQGVNYVTGDYSRGASGYWVENGVIQYPVEEITIAGNMKDMLRQ 425 +LK+MGTGLLVTELMGQG N +TGDYSRGA+G+WVENGVI YPV EIT+AG ++DM R Sbjct: 356 -LLKEMGTGLLVTELMGQGANTITGDYSRGAAGFWVENGVIAYPVHEITVAGRLQDMYRD 414 Query: 426 IVAVGNDTLIRGTKETGSILLESMTIAG 453 IV V +D L R + + GSIL+ MT+AG Sbjct: 415 IVGVADDALRRSSNKIGSILIAGMTVAG 442 >NMB0839 [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs Nme Neisseria meningitidis MC58 Length = 443 Score = 442 bits (1138), Expect = e-124, Method: Compositional matrix adjust. Identities = 224/448 (50%), Positives = 302/448 (67%), Gaps = 8/448 (1%) Query: 6 FTHSQDQLKQLAQDVLRYARDKGASDAAVDISEGSGLSVAVRKGRIETIEQNKDKGIGVT 65 F H+ +L L + L A+ GA+ A D SE G SV+VR G IE IE +DK + +T Sbjct: 3 FNHTASELLDLCRRTLDLAKATGATAAEADFSESLGQSVSVRLGEIEQIEFQQDKSLDIT 62 Query: 66 VFLGEGRQVRRGNASTSDFSQQALKETVEAAYNIARFTSIDDCAGLPDAEMLEMAPRDLK 125 V++G+ R+G AST+DFS++AL++TV+AA +IAR T+ D CAGL DA ++ D Sbjct: 63 VYVGK----RKGRASTADFSEKALQDTVKAAIDIARHTAEDGCAGLADACLMAKHIGDPD 118 Query: 126 LFSPWNISAEEAVALAQRCETAALETDPRISNSEGAGVYVQHSHFIAANSRGFMGGYPFS 185 L+ W++ E AV LA++CE AAL D RI NSEGA V H ++ N+ GF + Sbjct: 119 LYHEWDLDTEAAVGLAKQCEQAALNEDERIENSEGAAVQTGHYQYVYGNTHGFAAHRQGT 178 Query: 186 RHTISVAPIAGKGASMQRDDWYSSKRDPKKLAQPEAIGRYAAERALARLNARKLSTRKCP 245 H+IS + +A MQRD WY S + PE IG+ AA R L RL +R + T P Sbjct: 179 HHSISCSVVAADENGMQRDYWYDSACRHPDMDSPETIGQTAARRTLRRLGSRSIPTGSYP 238 Query: 246 VLFEAPLAAGLLGAFVQAVSGGALYRKSTFLLDSLGQQVFPEHIQILEDPHVIGGVGSAP 305 VLF+ ++ GL+G V A+SGGALYR+S+FL+DS+G++V P+ + + E+PH+ S+ Sbjct: 239 VLFDTTVSGGLIGHLVGALSGGALYRQSSFLIDSIGKKVLPDFLNLREEPHIPRSFRSSY 298 Query: 306 FDEEGVRTLKREVVRNGVVQGYFLSTYSARKLGMQTTGNSGGSHNLTLRSELTTRADTFK 365 FD EGV T R V++NG+V+GYFLS+YSARKLGMQTTGN+GG+HNL L T++D Sbjct: 299 FDAEGVATAPRFVIQNGIVEGYFLSSYSARKLGMQTTGNAGGAHNLYLNHTHETQSD--- 355 Query: 366 GMLKKMGTGLLVTELMGQGVNYVTGDYSRGASGYWVENGVIQYPVEEITIAGNMKDMLRQ 425 +LK+MGTGLLVTELMGQG N +TGDYSRGA+G+WVENGVI YPV EIT+AG ++DM R Sbjct: 356 -LLKEMGTGLLVTELMGQGANTITGDYSRGAAGFWVENGVIAYPVHEITVAGRLQDMYRD 414 Query: 426 IVAVGNDTLIRGTKETGSILLESMTIAG 453 IV V +D L R + + GSIL+ MT+AG Sbjct: 415 IVGVADDALRRSSNKIGSILIAGMTVAG 442 >pmbA [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs Eco Escherichia coli K12 Length = 450 Score = 422 bits (1086), Expect = e-118, Method: Compositional matrix adjust. Identities = 212/427 (49%), Positives = 292/427 (68%), Gaps = 9/427 (2%) Query: 28 GASDAA-VDISEGSGLSVAVRKGRIETIEQNKDKGIGVTVFLGEGRQVRRGNASTSDFSQ 86 G SD A V +S+ +G+SV+ R G +E +E N D +G+TV+ Q R+G+AS++D S Sbjct: 31 GKSDGAEVAVSKTTGISVSTRYGEVENVEFNSDGALGITVY----HQNRKGSASSTDLSP 86 Query: 87 QALKETVEAAYNIARFTSIDDCAGLPDAEMLEMAPRDLKLFSPWNISAEEAVALAQRCET 146 QA+ TV+AA +IAR+TS D CAG+ D E+L DL LF P +S +EA+ LA R E Sbjct: 87 QAIARTVQAALDIARYTSPDPCAGVADKELLAFDAPDLDLFHPAEVSPDEAIELAARAEQ 146 Query: 147 AALETDPRISNSEGAGVYVQHSHFIAANSRGFMGGYPFSRHTISVAPIAGKGASMQRDDW 206 AAL+ D RI+N+EG + + NS G + GY +RH++S IA + M+RD Sbjct: 147 AALQADKRITNTEGGSFNSHYGVKVFGNSHGMLQGYCSTRHSLSSCVIAEENGDMERDYA 206 Query: 207 YSSKRDPKKLAQPEAIGRYAAERALARLNARKLSTRKCPVLFEAPLAAGLLGAFVQAVSG 266 Y+ R L PE +G A R L+RL+ RKLST K PV+F +A GL G V A++G Sbjct: 207 YTIGRAMSDLQTPEWVGADCARRTLSRLSPRKLSTMKAPVIFANEVATGLFGHLVGAIAG 266 Query: 267 GALYRKSTFLLDSLGQQVFPEHIQILEDPHVIGGVGSAPFDEEGVRTLKREVVRNGVVQG 326 G++YRKSTFLLDSLG+Q+ P+ + I E PH++ G+ S PFD EGVRT +R+++++G++ Sbjct: 267 GSVYRKSTFLLDSLGKQILPDWLTIEEHPHLLKGLASTPFDSEGVRTERRDIIKDGILTQ 326 Query: 327 YFLSTYSARKLGMQTTGNSGGSHNLTLRSELTTRADTFKGMLKKMGTGLLVTELMGQGVN 386 + L++YSARKLG+++TG++GG HN + + +F+ MLK+MGTGL+VTELMGQGV+ Sbjct: 327 WLLTSYSARKLGLKSTGHAGGIHNW----RIAGQGLSFEQMLKEMGTGLVVTELMGQGVS 382 Query: 387 YVTGDYSRGASGYWVENGVIQYPVEEITIAGNMKDMLRQIVAVGNDTLIRGTKETGSILL 446 +TGDYSRGA+G+WVENG IQYPV EITIAGN+KDM R IV VGND R + GS+LL Sbjct: 383 AITGDYSRGAAGFWVENGEIQYPVSEITIAGNLKDMWRNIVTVGNDIETRSNIQCGSVLL 442 Query: 447 ESMTIAG 453 M IAG Sbjct: 443 PEMKIAG 449 >ZpmbA [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs EcZ Escherichia coli O157:H7 EDL933 Length = 450 Score = 422 bits (1086), Expect = e-118, Method: Compositional matrix adjust. Identities = 212/427 (49%), Positives = 292/427 (68%), Gaps = 9/427 (2%) Query: 28 GASDAA-VDISEGSGLSVAVRKGRIETIEQNKDKGIGVTVFLGEGRQVRRGNASTSDFSQ 86 G SD A V +S+ +G+SV+ R G +E +E N D +G+TV+ Q R+G+AS++D S Sbjct: 31 GKSDGAEVAVSKTTGISVSTRYGEVENVEFNSDGALGITVY----HQNRKGSASSTDLSP 86 Query: 87 QALKETVEAAYNIARFTSIDDCAGLPDAEMLEMAPRDLKLFSPWNISAEEAVALAQRCET 146 QA+ TV+AA +IAR+TS D CAG+ D E+L DL LF P +S +EA+ LA R E Sbjct: 87 QAIARTVQAALDIARYTSPDPCAGVADKELLAFDAPDLDLFHPAEVSPDEAIELAARAEQ 146 Query: 147 AALETDPRISNSEGAGVYVQHSHFIAANSRGFMGGYPFSRHTISVAPIAGKGASMQRDDW 206 AAL+ D RI+N+EG + + NS G + GY +RH++S IA + M+RD Sbjct: 147 AALQADKRITNTEGGSFNSHYGVKVFGNSHGMLQGYCSTRHSLSSCVIAEENGDMERDYA 206 Query: 207 YSSKRDPKKLAQPEAIGRYAAERALARLNARKLSTRKCPVLFEAPLAAGLLGAFVQAVSG 266 Y+ R L PE +G A R L+RL+ RKLST K PV+F +A GL G V A++G Sbjct: 207 YTIGRAMSDLQTPEWVGADCARRTLSRLSPRKLSTMKAPVIFANEVATGLFGHLVGAIAG 266 Query: 267 GALYRKSTFLLDSLGQQVFPEHIQILEDPHVIGGVGSAPFDEEGVRTLKREVVRNGVVQG 326 G++YRKSTFLLDSLG+Q+ P+ + I E PH++ G+ S PFD EGVRT +R+++++G++ Sbjct: 267 GSVYRKSTFLLDSLGKQILPDWLTIEEHPHLLKGLASTPFDSEGVRTERRDIIKDGILTQ 326 Query: 327 YFLSTYSARKLGMQTTGNSGGSHNLTLRSELTTRADTFKGMLKKMGTGLLVTELMGQGVN 386 + L++YSARKLG+++TG++GG HN + + +F+ MLK+MGTGL+VTELMGQGV+ Sbjct: 327 WLLTSYSARKLGLKSTGHAGGIHNW----RIAGQGLSFEQMLKEMGTGLVVTELMGQGVS 382 Query: 387 YVTGDYSRGASGYWVENGVIQYPVEEITIAGNMKDMLRQIVAVGNDTLIRGTKETGSILL 446 +TGDYSRGA+G+WVENG IQYPV EITIAGN+KDM R IV VGND R + GS+LL Sbjct: 383 AITGDYSRGAAGFWVENGEIQYPVSEITIAGNLKDMWRNIVTVGNDIETRSNIQCGSVLL 442 Query: 447 ESMTIAG 453 M IAG Sbjct: 443 PEMKIAG 449