BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0005.0004.p         (221 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

aq_1362 [CR] COG0604 NADPH Aae Aquifex aeolicus                        73   6e-13
ML2355 [Q] COG3321 Polyketide synthase modules and related prote...    67   3e-11
MT3003 [Q] COG3321 Polyketide synthase modules and related prote...    67   4e-11
Rv2933 [Q] COG3321 Polyketide synthase modules and related prote...    67   4e-11
VNG1821G [CR] COG0604 NADPH Hbs Halobacterium sp. NRC-1                66   6e-11

>aq_1362 [CR] COG0604 NADPH Aae Aquifex aeolicus
          Length = 343

 Score = 72.8 bits (177), Expect = 6e-13,   Method: Compositional matrix adjust.
 Identities = 53/190 (27%), Positives = 87/190 (45%), Gaps = 19/190 (10%)

Query: 1   VYVNPGLSCGSCEACRRGDPINCTAFTFQGYFGFGPGSQKIFEDYPYAGFGQYMTAPAAN 60
           V + PGLSCG C  C+ G   +C  +   G    G             G+ +Y+  PA N
Sbjct: 86  VIIAPGLSCGVCWDCQSGRDNHCKDYDILGLKNKG-------------GYAEYVAVPARN 132

Query: 61  LVKLPDSISFEQAARF--GYLGTAYSALRKAQFAPGQTVLIDGGTGTLGLGAVILALAMG 118
           ++K P ++SFE+AA +   +L    + + KAQ  P   V I  G+  +G+  + LA A  
Sbjct: 133 VIKKPKNLSFEEAASYPLTFLTVWNALVDKAQIKPYSRVFIWAGSSGVGVAGIQLAKAFN 192

Query: 119 AAKIYATARNKALLDRVRSIDPKRIIPIVMGEGSVAESVMEATNGYGVDVLIEXRARARF 178
           A  +  TA N+    + + +    +      +  V + V E     GVDV+++    A F
Sbjct: 193 AF-VITTAGNEEKAKKCKELGADLVFN--HYKDDVVKKVREVFK-EGVDVVVDHIGEATF 248

Query: 179 FQCVAPWRQG 188
           ++ V   R+G
Sbjct: 249 WKSVQMLRKG 258


>ML2355 [Q] COG3321 Polyketide synthase modules and related proteins Mle
            Mycobacterium leprae
          Length = 2201

 Score = 67.0 bits (162), Expect = 3e-11,   Method: Compositional matrix adjust.
 Identities = 56/174 (32%), Positives = 87/174 (50%), Gaps = 24/174 (13%)

Query: 18   GDPINCTAFTFQGYFGFGPGSQKIFEDYPYAGFGQYMTAPAANLVKLPDSISFEQAARFG 77
            GD ++      Q    FGPG+           FG Y+   A  +V +PD++S  +AA FG
Sbjct: 1543 GDDVDSVEVG-QRVIAFGPGT-----------FGTYVGTIADLVVPIPDTLSDHEAATFG 1590

Query: 78   --YLGTAYSALRKAQFAPGQTVLIDGGTGTLGLGAVILALAMGAAKIYATARNKALLDRV 135
              YL   +      + +PG+ VLI   TG +G+ AV +A  +G A+IY TA +    D  
Sbjct: 1591 VAYLTAWHCLCEVGRLSPGERVLIHSATGGVGMAAVSIAKMLG-ARIYTTAGS----DAK 1645

Query: 136  RSIDPKRIIPIVMGEGSV--AESVMEATNGYGVDVLIEX---RARARFFQCVAP 184
            R +  +  +  V    SV  A+ ++E T+GYGVD+++     +A  R  Q +AP
Sbjct: 1646 RQMLSELGVEYVGDSRSVDFADEILELTHGYGVDIILNSLADKAIQRGVQILAP 1699


>MT3003 [Q] COG3321 Polyketide synthase modules and related proteins MtC
            Mycobacterium tuberculosis CDC1551
          Length = 2188

 Score = 66.6 bits (161), Expect = 4e-11,   Method: Compositional matrix adjust.
 Identities = 55/172 (31%), Positives = 84/172 (48%), Gaps = 41/172 (23%)

Query: 29   QGYFGFGPGSQKIFEDYPYAGFGQYMTAPAANLVKLPDSISFEQAARFG--YLGTAYSAL 86
            Q    FGPG+           FG ++   A  +V +PD+++  +AA FG  YL   +S  
Sbjct: 1540 QRVIAFGPGT-----------FGTHLGTIADLVVPIPDTLADNEAATFGVAYLTAWHSLC 1588

Query: 87   RKAQFAPGQTVLIDGGTGTLGLGAVILALAMGAAKIYATARNKA---LLDRV-------- 135
               + +PG+ VLI   TG +G+ AV +A  +G A+IY TA + A   +L R+        
Sbjct: 1589 EVGRLSPGERVLIHSATGGVGMAAVSIAKMIG-ARIYTTAGSDAKREMLSRLGVEYVGDS 1647

Query: 136  RSIDPKRIIPIVMGEGSVAESVMEATNGYGVDVLIEX---RARARFFQCVAP 184
            RS+D              A+ ++E T+GYGVDV++      A  R  Q +AP
Sbjct: 1648 RSVD-------------FADEILELTDGYGVDVVLNSLAGEAIQRGVQILAP 1686


>Rv2933 [Q] COG3321 Polyketide synthase modules and related proteins Mtu
            Mycobacterium tuberculosis H37Rv
          Length = 2188

 Score = 66.6 bits (161), Expect = 4e-11,   Method: Compositional matrix adjust.
 Identities = 55/172 (31%), Positives = 84/172 (48%), Gaps = 41/172 (23%)

Query: 29   QGYFGFGPGSQKIFEDYPYAGFGQYMTAPAANLVKLPDSISFEQAARFG--YLGTAYSAL 86
            Q    FGPG+           FG ++   A  +V +PD+++  +AA FG  YL   +S  
Sbjct: 1540 QRVIAFGPGT-----------FGTHLGTIADLVVPIPDTLADNEAATFGVAYLTAWHSLC 1588

Query: 87   RKAQFAPGQTVLIDGGTGTLGLGAVILALAMGAAKIYATARNKA---LLDRV-------- 135
               + +PG+ VLI   TG +G+ AV +A  +G A+IY TA + A   +L R+        
Sbjct: 1589 EVGRLSPGERVLIHSATGGVGMAAVSIAKMIG-ARIYTTAGSDAKREMLSRLGVEYVGDS 1647

Query: 136  RSIDPKRIIPIVMGEGSVAESVMEATNGYGVDVLIEX---RARARFFQCVAP 184
            RS+D              A+ ++E T+GYGVDV++      A  R  Q +AP
Sbjct: 1648 RSVD-------------FADEILELTDGYGVDVVLNSLAGEAIQRGVQILAP 1686


>VNG1821G [CR] COG0604 NADPH Hbs Halobacterium sp. NRC-1
          Length = 347

 Score = 65.9 bits (159), Expect = 6e-11,   Method: Compositional matrix adjust.
 Identities = 45/134 (33%), Positives = 69/134 (51%), Gaps = 16/134 (11%)

Query: 1   VYVNPGLSCGSCEACRRGDPINCTAFTFQGYFGFGPGSQKIFEDYPYAGFGQYMTAPAAN 60
           V V  G+SCG CE CR G+P  C +F   G    G  S++                PA N
Sbjct: 85  VAVLAGVSCGQCEFCRHGEPALCASFRVLGEHVPGVHSER-------------AAVPADN 131

Query: 61  LVKLPDSISFEQAARFGYL-GTAYSALR-KAQFAPGQTVLIDGGTGTLGLGAVILALAMG 118
           L+ +P+ + +E AA    +  TA+  L  +A  +PG++VL+ G +G +G  AV +A A  
Sbjct: 132 LIAVPEHVDWETAAAAPLVFQTAWRMLNTRADVSPGESVLVLGASGGVGHAAVQIA-AHA 190

Query: 119 AAKIYATARNKALL 132
            A+++ATA  +  L
Sbjct: 191 GAEVFATASTEQKL 204