BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0004.0020.p (318 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2357 [H] COG0181 Porphobilinogen deaminase Rso Ralstonia sola... 359 5e-99 NMA0718 [H] COG0181 Porphobilinogen deaminase NmA Neisseria meni... 351 2e-96 NMB0539 [H] COG0181 Porphobilinogen deaminase Nme Neisseria meni... 349 4e-96 PA5260 [H] COG0181 Porphobilinogen deaminase Pae Pseudomonas aer... 314 2e-85 VC0120 [H] COG0181 Porphobilinogen deaminase Vch Vibrio cholerae 310 3e-84 >RSc2357 [H] COG0181 Porphobilinogen deaminase Rso Ralstonia solanacearum Length = 334 Score = 359 bits (921), Expect = 5e-99, Method: Compositional matrix adjust. Identities = 206/316 (65%), Positives = 236/316 (74%), Gaps = 4/316 (1%) Query: 6 PSNIVIVSRESRLAMWQAEYVRDRLAALYPQCSISILGTTTRGDQILDRALSKVGGKGLF 65 P+ +VI SRESRLAMWQAEYVR L YP C +SILG TTRGDQILDR+L+KVGGKGLF Sbjct: 19 PTKLVIASRESRLAMWQAEYVRAALQKYYPACDVSILGMTTRGDQILDRSLAKVGGKGLF 78 Query: 66 VKELEVAMAEGRADLAVHCLKDMPMDLPEGFELAAILEREDPRDAFVSNDYAALDELPDG 125 VKELEVA+AEGRADLAVH LKD+PM+LP GF L+AILEREDPRDAFVSNDYA L LP G Sbjct: 79 VKELEVALAEGRADLAVHSLKDVPMELPPGFVLSAILEREDPRDAFVSNDYADLAALPAG 138 Query: 126 AVVGTSSLRRQAMIAARYPQLVVKPLRGNLDTRLAKLDRGDYAAIILAVAGLNRLGLKAR 185 AVVGTSSLRR+A + AR+P LV++PLRGNLDTRL+KLDRGDYAAIILA AGL RLGL R Sbjct: 139 AVVGTSSLRREASLRARFPHLVIQPLRGNLDTRLSKLDRGDYAAIILAAAGLKRLGLSER 198 Query: 186 IRSFLDPAQSLPSPGQGTLAIEIPEGREDIKRLLAPLHDEPAAVVSAAERSVSRIFGASC 245 IR+ + P SLP+ GQG L IE R D++ LAPLH P A+ AER+VSR G SC Sbjct: 199 IRAVIAPETSLPAAGQGALGIESRVDRHDVQAWLAPLHHAPTALAVTAERAVSRQLGGSC 258 Query: 246 QIPLAAYATL-DGQRLHLRAMIATPDG---LHAAAAEAEGPAAAPEALGAQVAELLKVRG 301 Q+PLAA+A D L LRA +A+PDG L A A A EALGA+VA+ + G Sbjct: 259 QVPLAAFAQWTDAGALRLRAFVASPDGRRKLAAEAEATPATPAEAEALGARVAQQMLDGG 318 Query: 302 ADDILAACKAQADAAS 317 A DILA A A A+ Sbjct: 319 AHDILATLGADAPPAT 334 >NMA0718 [H] COG0181 Porphobilinogen deaminase NmA Neisseria meningitidis Z2491 Length = 311 Score = 351 bits (900), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 179/303 (59%), Positives = 220/303 (72%) Query: 6 PSNIVIVSRESRLAMWQAEYVRDRLAALYPQCSISILGTTTRGDQILDRALSKVGGKGLF 65 P +VI SRES LAMWQA++++ RL ALYP C + ILG TTRGDQILD+ LSKVGGKGLF Sbjct: 3 PKKLVIASRESLLAMWQAKHIQGRLKALYPDCEVEILGMTTRGDQILDKTLSKVGGKGLF 62 Query: 66 VKELEVAMAEGRADLAVHCLKDMPMDLPEGFELAAILEREDPRDAFVSNDYAALDELPDG 125 VKELE A+ +GRADLAVH +KD+PMDLPEGF LAAI ER +P DAFVSN YA L+E+P+G Sbjct: 63 VKELEQALYDGRADLAVHSIKDVPMDLPEGFALAAIGERANPFDAFVSNQYARLEEMPEG 122 Query: 126 AVVGTSSLRRQAMIAARYPQLVVKPLRGNLDTRLAKLDRGDYAAIILAVAGLNRLGLKAR 185 AVVGTSSLRR+A + ARYP L++KPLRGN+ TRL+KLD G+Y AIILA AGL RL L R Sbjct: 123 AVVGTSSLRREAQLRARYPHLLIKPLRGNVQTRLSKLDNGEYDAIILAAAGLQRLKLDGR 182 Query: 186 IRSFLDPAQSLPSPGQGTLAIEIPEGREDIKRLLAPLHDEPAAVVSAAERSVSRIFGASC 245 IR L + SLP+ GQG L IEI RED+ +L PL+ AER+++R G SC Sbjct: 183 IRMILSESDSLPAAGQGALGIEIAAHREDLYEVLKPLNHGVTNACVTAERALARALGGSC 242 Query: 246 QIPLAAYATLDGQRLHLRAMIATPDGLHAAAAEAEGPAAAPEALGAQVAELLKVRGADDI 305 Q+PLAAY T + L LR ++ PDG A+A+ PA +ALG VA+ L GA ++ Sbjct: 243 QVPLAAYCTEENGLLTLRGLVGHPDGSVVLRADAQAPAEYADALGRAVAKKLADDGAREL 302 Query: 306 LAA 308 + A Sbjct: 303 IGA 305 >NMB0539 [H] COG0181 Porphobilinogen deaminase Nme Neisseria meningitidis MC58 Length = 311 Score = 349 bits (896), Expect = 4e-96, Method: Compositional matrix adjust. Identities = 178/303 (58%), Positives = 219/303 (72%) Query: 6 PSNIVIVSRESRLAMWQAEYVRDRLAALYPQCSISILGTTTRGDQILDRALSKVGGKGLF 65 P +VI SRES LAMWQA++++ RL ALYP C + ILG TTRGDQILD+ LSKVGGKGLF Sbjct: 3 PKKLVIASRESLLAMWQAKHIQGRLKALYPDCEVEILGMTTRGDQILDKTLSKVGGKGLF 62 Query: 66 VKELEVAMAEGRADLAVHCLKDMPMDLPEGFELAAILEREDPRDAFVSNDYAALDELPDG 125 VKELE A+ +GRADLAVH +KD+PMDLPEGF LAAI ER +P DAFVSN Y L+E+P+G Sbjct: 63 VKELEQALYDGRADLAVHSIKDVPMDLPEGFALAAIGERANPFDAFVSNQYTRLEEMPEG 122 Query: 126 AVVGTSSLRRQAMIAARYPQLVVKPLRGNLDTRLAKLDRGDYAAIILAVAGLNRLGLKAR 185 AVVGTSSLRR+A + ARYP L++KPLRGN+ TRL+KLD G+Y AIILA AGL RL L R Sbjct: 123 AVVGTSSLRREAQLRARYPHLLIKPLRGNVQTRLSKLDNGEYDAIILAAAGLQRLKLDGR 182 Query: 186 IRSFLDPAQSLPSPGQGTLAIEIPEGREDIKRLLAPLHDEPAAVVSAAERSVSRIFGASC 245 IR L + SLP+ GQG L IEI RED+ +L PL+ AER+++R G SC Sbjct: 183 IRMILSESDSLPAAGQGALGIEIAAHREDLYEVLKPLNHGVTNACVTAERALARALGGSC 242 Query: 246 QIPLAAYATLDGQRLHLRAMIATPDGLHAAAAEAEGPAAAPEALGAQVAELLKVRGADDI 305 Q+PLAAY T + L LR ++ PDG A+A+ PA +ALG VA+ L GA ++ Sbjct: 243 QVPLAAYCTEENGLLTLRGLVGHPDGSVVLRADAQAPAEYADALGRAVAKKLADDGAREL 302 Query: 306 LAA 308 + A Sbjct: 303 IGA 305 >PA5260 [H] COG0181 Porphobilinogen deaminase Pae Pseudomonas aeruginosa Length = 313 Score = 314 bits (805), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 163/306 (53%), Positives = 212/306 (69%) Query: 8 NIVIVSRESRLAMWQAEYVRDRLAALYPQCSISILGTTTRGDQILDRALSKVGGKGLFVK 67 I I +R+S LA+WQAEYV+ RL +P ++++L T+RGD++LD L+K+GGKGLFVK Sbjct: 5 EIRIATRQSALALWQAEYVKARLEQAHPGLTVTLLPMTSRGDKLLDAPLAKIGGKGLFVK 64 Query: 68 ELEVAMAEGRADLAVHCLKDMPMDLPEGFELAAILEREDPRDAFVSNDYAALDELPDGAV 127 ELE A+ EG AD+AVH +KD+PMD PEG L I EREDPRDAFVSN YA+L++LP G+V Sbjct: 65 ELETALLEGAADIAVHSMKDVPMDFPEGLGLYTICEREDPRDAFVSNTYASLEQLPAGSV 124 Query: 128 VGTSSLRRQAMIAARYPQLVVKPLRGNLDTRLAKLDRGDYAAIILAVAGLNRLGLKARIR 187 VGTSSLRRQA + AR P L ++ LRGN++TRLAKLD G+Y AIILA AGL RLG ++RIR Sbjct: 125 VGTSSLRRQAQLLARRPDLQIRFLRGNVNTRLAKLDAGEYDAIILAAAGLIRLGFESRIR 184 Query: 188 SFLDPAQSLPSPGQGTLAIEIPEGREDIKRLLAPLHDEPAAVVSAAERSVSRIFGASCQI 247 S + SLP+ GQG + IE D+ LL PLH A+ AER++++ CQ+ Sbjct: 185 SSISVDDSLPAGGQGAVGIECRTADSDLHALLEPLHHTDTALRVTAERALNKRLNGGCQV 244 Query: 248 PLAAYATLDGQRLHLRAMIATPDGLHAAAAEAEGPAAAPEALGAQVAELLKVRGADDILA 307 P+A YA +G +L LR ++ PDG AE P A EALG +VAE L +GA+ IL Sbjct: 245 PIACYAIREGDQLWLRGLVGQPDGTQLLRAEGRAPLAEAEALGVRVAEDLLEQGAEAILE 304 Query: 308 ACKAQA 313 A +A Sbjct: 305 AVYGEA 310 >VC0120 [H] COG0181 Porphobilinogen deaminase Vch Vibrio cholerae Length = 317 Score = 310 bits (794), Expect = 3e-84, Method: Compositional matrix adjust. Identities = 158/298 (53%), Positives = 204/298 (68%) Query: 9 IVIVSRESRLAMWQAEYVRDRLAALYPQCSISILGTTTRGDQILDRALSKVGGKGLFVKE 68 I I +R+S LA+WQA YV+D L A +P + ++ TRGD ILD L+KVGGKGLFVKE Sbjct: 12 IRIATRQSPLALWQANYVKDALMAAHPGLQVELVTMVTRGDVILDTPLAKVGGKGLFVKE 71 Query: 69 LEVAMAEGRADLAVHCLKDMPMDLPEGFELAAILEREDPRDAFVSNDYAALDELPDGAVV 128 LE+AM EGRADLAVH +KD+P+D P+G L I EREDPRDAFVSN YA +++LP GA+V Sbjct: 72 LEIAMLEGRADLAVHSMKDVPVDFPDGLGLVTICEREDPRDAFVSNTYAKIEDLPSGAIV 131 Query: 129 GTSSLRRQAMIAARYPQLVVKPLRGNLDTRLAKLDRGDYAAIILAVAGLNRLGLKARIRS 188 GT SLRRQ + A P LV+K LRGN+ TRL+KLD G+Y AIILA AGL RL L++RIRS Sbjct: 132 GTCSLRRQCQLKAARPDLVIKELRGNVGTRLSKLDAGEYDAIILAAAGLKRLELESRIRS 191 Query: 189 FLDPAQSLPSPGQGTLAIEIPEGREDIKRLLAPLHDEPAAVVSAAERSVSRIFGASCQIP 248 F++P QSLP+ GQG + IE + ++ LLAPL+ A ER+++ CQ+P Sbjct: 192 FIEPEQSLPAVGQGAVGIECRVNDQRVRALLAPLNHADTADRVRCERAMNLTLQGGCQVP 251 Query: 249 LAAYATLDGQRLHLRAMIATPDGLHAAAAEAEGPAAAPEALGAQVAELLKVRGADDIL 306 + +YA L+G + LRA++ PDG E GP E LG +AE L +GA +IL Sbjct: 252 IGSYALLEGDTIWLRALVGEPDGSQIVRGEIRGPRTQAEQLGITLAEQLLSQGAKEIL 309