BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0003.0150.p (261 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1147 [R] COG1235 Metal-dependent hydrolases of the beta-lacta... 268 1e-71 PA1012 [R] COG1235 Metal-dependent hydrolases of the beta-lactam... 233 3e-61 lin0319 [R] COG1235 Metal-dependent hydrolases of the beta-lacta... 162 9e-40 BH4023 [R] COG1235 Metal-dependent hydrolases of the beta-lactam... 151 1e-36 CAC3538 [R] COG1235 Metal-dependent hydrolases of the beta-lacta... 149 8e-36 >RSc1147 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Rso Ralstonia solanacearum Length = 261 Score = 268 bits (684), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 138/260 (53%), Positives = 176/260 (67%), Gaps = 6/260 (2%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 ++FASLGSGS+GNALL+ + G ++ T ++LDCGF +RE RR+ RLG P+ + AI Sbjct: 3 VRFASLGSGSDGNALLVESTDG----TTSTRILLDCGFGIRETVRRLERLGCAPASLDAI 58 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVAD--QATDVDVQFCADGQKLAIGDLE 118 +VTHEH DH+ + FA +Y +PVW S+GT++A A A V+FC +IGDL Sbjct: 59 LVTHEHGDHIGSAYAFAAKYSVPVWTSHGTYRATASLRGADRAAVRFCRADDAFSIGDLR 118 Query: 119 LSPYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLD 178 + PYTVPHDAREP+Q++ DG RRLGVLTDAG T +L L A +LECNHDR+ML Sbjct: 119 ILPYTVPHDAREPLQFIFDDGARRLGVLTDAGMSTEYLCGHLTGLHAFVLECNHDREMLA 178 Query: 179 RSPYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALEG 238 S YP LK+RIGGD+GHLAND +A IL + L V+ AHLS+QNNTPELA AA+ Sbjct: 179 NSAYPWSLKQRIGGDFGHLANDIAAAILARVRHDGLHTVVAAHLSKQNNTPELAAAAIAS 238 Query: 239 VLGTTFGDIGIACQAEGFGW 258 LG GD+ IA Q G GW Sbjct: 239 ALGVPAGDVPIADQEAGLGW 258 >PA1012 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Pae Pseudomonas aeruginosa Length = 252 Score = 233 bits (595), Expect = 3e-61, Method: Compositional matrix adjust. Identities = 123/261 (47%), Positives = 165/261 (63%), Gaps = 10/261 (3%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 M+FA LGSGS GN+ L+S SS T +++DCGF LRE +R+ RLGL P+ + AI Sbjct: 1 MRFAVLGSGSRGNSALVS--------SSDTRILIDCGFPLREIIKRLARLGLSPAQLDAI 52 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQFCADGQKLAIGDLELS 120 +VTHEH+DH+ GV AR Y+IPV+LS GT + V+ GQ+LAI LE+ Sbjct: 53 LVTHEHADHIHGVELLARHYQIPVYLSAGTLSGMRRPVHPVE--LLRAGQRLAIRGLEVQ 110 Query: 121 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRS 180 V HDAREP Q+V DG RR G+LTD G TA +++ A DAL++E NHD ML Sbjct: 111 VVGVSHDAREPTQFVLSDGQRRFGMLTDLGVATAEVLECYRAVDALVVEANHDSTMLAGG 170 Query: 181 PYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALEGVL 240 PYP FLK R+GG GHL N SAE+++ LD R++ ++ AHLS++NN+P+LAR L Sbjct: 171 PYPYFLKARVGGSRGHLNNHQSAELVKQLDWGRMQHLVLAHLSEKNNSPQLARQTFVDTL 230 Query: 241 GTTFGDIGIACQAEGFGWLDV 261 G G + +A Q G W ++ Sbjct: 231 GCDPGWLQVADQHSGLDWREI 251 >lin0319 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Lin Listeria innocua Length = 276 Score = 162 bits (409), Expect = 9e-40, Method: Compositional matrix adjust. Identities = 85/252 (33%), Positives = 147/252 (58%), Gaps = 13/252 (5%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 ++F+ L SGS GNA L+ GDQ+ +++DCG + ++ E ++G D +D+ AI Sbjct: 15 IRFSILASGSSGNATLVET--GDQK------ILIDCGLSGKKMEGLFAQVGRDMNDLDAI 66 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQA----VADQATDVDVQFCADGQKLAIGD 116 ++THEHSDH+ G+ AR+Y++P++ + TW+A + + +++ QF + K + G Sbjct: 67 LITHEHSDHIKGLGVLARKYKLPIYANAKTWKAMDNMIGEVSSEQKFQFDMETVK-SFGS 125 Query: 117 LELSPYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDM 176 +++ + V HDA EP+ Y+ G+++ ++TD G + + + DA L E NHD +M Sbjct: 126 MQVESFGVSHDAIEPMFYIFHKGNKKFVMITDTGYVSDRMKGHIAGADAYLFESNHDVEM 185 Query: 177 LDRSPYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAAL 236 L YP +KRRI GD GH++N+ +A + + + K + HLS+ NN ELAR ++ Sbjct: 186 LRMGRYPWNVKRRILGDEGHVSNEDAAIAMSEVITDQTKRIYLGHLSKDNNMKELARMSV 245 Query: 237 EGVLGTTFGDIG 248 L + D+G Sbjct: 246 TQTLISEGIDVG 257 >BH4023 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Bha Bacillus halodurans Length = 264 Score = 151 bits (382), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 86/244 (35%), Positives = 132/244 (54%), Gaps = 13/244 (5%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 ++F+ L SGS GNAL + + +++D G + ++ + ++ DPS ++ I Sbjct: 3 LRFSVLASGSTGNALYVE--------TDKQKLLVDAGLSGKKMDELFQKIDCDPSQLNGI 54 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQ----ATDVDVQFCADGQKLAIGD 116 +VTHEHSDH+ GV AR+Y +P++ + TWQA+ TD F G+ D Sbjct: 55 LVTHEHSDHIKGVGIVARKYNLPIYANAKTWQAMEKALGTLTTDQRFHFEI-GEVKTFAD 113 Query: 117 LELSPYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDM 176 LE+ + V HDA EP+ YV ++L + TD G + + + + D L+ E NHD +M Sbjct: 114 LEVESFGVSHDAAEPMFYVFHHDGKKLVLATDMGYVSERIKKTIENADTLIFEANHDLNM 173 Query: 177 LDRSPYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAAL 236 L YP +KRRI D GH++N+ +A L + R + + AHLS NN ELAR + Sbjct: 174 LRMGRYPWNVKRRILSDVGHVSNEDAAYALAEVIGDRTERIYLAHLSLDNNMKELARLTV 233 Query: 237 EGVL 240 E VL Sbjct: 234 EQVL 237 >CAC3538 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Cac Clostridium acetobutylicum Length = 261 Score = 149 bits (375), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 85/240 (35%), Positives = 132/240 (55%), Gaps = 14/240 (5%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 MKF SL SGS GN++ ++ S + V++D G + + E+ + + DP+++ I Sbjct: 1 MKFCSLYSGSSGNSIFVA--------SDNSKVLIDAGLSGKTIEKALKEIKEDPNEIDGI 52 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVAD---QATDVDVQFCADGQKLAIGDL 117 VTHEHSDH+ GV +R+Y IP++ + TW+A+ + + D +++ + I D+ Sbjct: 53 FVTHEHSDHIKGVGVLSRKYNIPIYANELTWKAMMNSIGKIKDDNIKIITQDY-IEIKDM 111 Query: 118 ELSPYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDML 177 + Y +PHDA P Y G++ V TD G + + D +LLE NHD +ML Sbjct: 112 NILNYKIPHDAASPCGYKILSGNKSACVATDLGHFADEVKSKISDADVILLESNHDVEML 171 Query: 178 DRSPYPAFLKRRIGGDYGHLAN-DASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAAL 236 PYP LKRRI + GHL+N D I+ + K + K ++G HLS+ NN PELA + Sbjct: 172 KFGPYPYPLKRRILSEVGHLSNEDCGKAIVDIAKKGKKKIILG-HLSRTNNYPELAYKTV 230