BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0003.0126.p (384 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1988 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase Rs... 634 0.0 NMB1031 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase Nm... 483 e-136 NMA1456 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase Nm... 478 e-134 PA3118 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase Pae... 469 e-132 XF2372 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase Xfa... 444 e-124 >RSc1988 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase Rso Ralstonia solanacearum Length = 363 Score = 634 bits (1634), Expect = 0.0, Method: Compositional matrix adjust. Identities = 310/362 (85%), Positives = 329/362 (90%), Gaps = 1/362 (0%) Query: 22 HREREAMKIAILPGDGIGPEIVNEAVRVLNALDEKFEMETAPVGGAGYEAHGHPLPDGTL 81 ++++ KIA+LPGDGIG EIV EAV+VL L E FEMETAPVGGAGYEA GHPLP+ TL Sbjct: 3 NKDKRMTKIAVLPGDGIGTEIVAEAVKVLKTLGETFEMETAPVGGAGYEAKGHPLPEDTL 62 Query: 82 KLAKEADAILFGAVGDWKYDKLERALRPEQAILGLRKHLQLFANFRPAICYPELTGASSL 141 KLAKEADAILFGAVGDWKYD L R LRPEQAILGLRKHLQLFANFRPAICYPEL GASS+ Sbjct: 63 KLAKEADAILFGAVGDWKYDTLPRELRPEQAILGLRKHLQLFANFRPAICYPELAGASSM 122 Query: 142 KPELVANLDILIVRELNGDIYFGQPRGXMREAPDGPFKGAREGFDTMRYSEPEIRRIAHV 201 KPE+VA LDILIVREL GDIYFGQPRG +R APDG F GAREGFDTMRYSEPEIRRIAHV Sbjct: 123 KPEIVAGLDILIVRELTGDIYFGQPRG-VRAAPDGLFAGAREGFDTMRYSEPEIRRIAHV 181 Query: 202 AFQAAAKRGKRLCSVDKANVLETFQFWKDIVTEVGKEYPDVELSHMYVDNAAMQLVKAPK 261 AFQAAAKRGK+LCSVDKANVLETFQFWKDIVT+V KEYP+VELSHMYVDNAAMQLVKAPK Sbjct: 182 AFQAAAKRGKKLCSVDKANVLETFQFWKDIVTDVHKEYPEVELSHMYVDNAAMQLVKAPK 241 Query: 262 NFDVIVTGNMFGDILSDAAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGIANP 321 NFDV+VTGNMFGDILSD AAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGIANP Sbjct: 242 NFDVVVTGNMFGDILSDEAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGIANP 301 Query: 322 LATILSAAMMLRFSLNKAEQADRIENAVKKVLAQGLRTADIYEEGCTKVNTQQMGEAVVK 381 LATILSAAMMLR++L KAEQADRIENAVKKVLAQG RT DI GC +V T +MG+AVV Sbjct: 302 LATILSAAMMLRYTLGKAEQADRIENAVKKVLAQGYRTGDILTPGCKQVGTVEMGDAVVA 361 Query: 382 AL 383 AL Sbjct: 362 AL 363 >NMB1031 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase Nme Neisseria meningitidis MC58 Length = 356 Score = 483 bits (1244), Expect = e-136, Method: Compositional matrix adjust. Identities = 241/359 (67%), Positives = 286/359 (79%), Gaps = 12/359 (3%) Query: 30 IAILPGDGIGPEIVNEAVRVLN-----ALDEKFEMETAPVGGAGYEAHGHPLPDGTLKLA 84 IAIL GDGIGPEIV E VRVL+ LD +E AP+GG Y+ +GHP P+ T L Sbjct: 5 IAILRGDGIGPEIVAETVRVLDKLIAQGLDAGYEY--APLGGEAYDEYGHPYPEFTQNLC 62 Query: 85 KEADAILFGAVGDWKYDKLERALRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPE 144 ++ADA+L GAVG +YD L+R LRPE+ +L +RK L LFAN RPA+ YPEL AS+LKPE Sbjct: 63 RKADAVLLGAVGSPQYDNLDRPLRPERGLLAIRKDLNLFANLRPAVLYPELANASTLKPE 122 Query: 145 LVANLDILIVRELNGDIYFGQPRGXMREAPDGPFKGAREGFDTMRYSEPEIRRIAHVAFQ 204 +VA LDILIVREL GDIYFG+PRG +R +G REG++TM+YSE EIRRIAHVAFQ Sbjct: 123 IVAGLDILIVRELTGDIYFGEPRG-IRVLENG----EREGYNTMKYSESEIRRIAHVAFQ 177 Query: 205 AAAKRGKRLCSVDKANVLETFQFWKDIVTEVGKEYPDVELSHMYVDNAAMQLVKAPKNFD 264 +A KR K++CSV KANVLET + W++I E+GKEYPDVELSHMYVDNAAMQLV+APK FD Sbjct: 178 SAQKRSKKVCSVGKANVLETTELWREIFEEIGKEYPDVELSHMYVDNAAMQLVRAPKQFD 237 Query: 265 VIVTGNMFGDILSDAAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGIANPLAT 324 VI TGN+FGDILSD A+MLTGSIGMLPSASLD N KGLYEPSHGSAPDIAG+ ANPLAT Sbjct: 238 VIATGNIFGDILSDEASMLTGSIGMLPSASLDENGKGLYEPSHGSAPDIAGQNKANPLAT 297 Query: 325 ILSAAMMLRFSLNKAEQADRIENAVKKVLAQGLRTADIYEEGCTKVNTQQMGEAVVKAL 383 ILS AM+LR+SLN +A ++ENAV+KVL QGLRT+DIYEEG V+ +MG+AV+ AL Sbjct: 298 ILSLAMLLRYSLNDEARAQQVENAVQKVLQQGLRTSDIYEEGTKLVSCSEMGDAVLAAL 356 >NMA1456 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase NmA Neisseria meningitidis Z2491 Length = 356 Score = 478 bits (1230), Expect = e-134, Method: Compositional matrix adjust. Identities = 238/357 (66%), Positives = 282/357 (78%), Gaps = 8/357 (2%) Query: 30 IAILPGDGIGPEIVNEAVRVLNALDEK---FEMETAPVGGAGYEAHGHPLPDGTLKLAKE 86 IAIL GDGIGPEIV E VRVL+ L + E AP+GG Y+ +GHP P+ T L ++ Sbjct: 5 IAILRGDGIGPEIVAETVRVLDKLIAQGLDVGYEYAPLGGEAYDEYGHPYPEFTQNLCRK 64 Query: 87 ADAILFGAVGDWKYDKLERALRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELV 146 ADA+L GAVG +YD L+R LRPE+ +L +RK L LFAN RPAI YPEL AS+LK E+V Sbjct: 65 ADAVLLGAVGSPQYDNLDRPLRPERGLLAIRKDLNLFANLRPAILYPELANASTLKSEIV 124 Query: 147 ANLDILIVRELNGDIYFGQPRGXMREAPDGPFKGAREGFDTMRYSEPEIRRIAHVAFQAA 206 A LDILIVREL GDIYFG+PRG +R +G REG++TM+YSE EIRRIAHVAFQ+A Sbjct: 125 AGLDILIVRELTGDIYFGEPRG-IRVLENG----EREGYNTMKYSESEIRRIAHVAFQSA 179 Query: 207 AKRGKRLCSVDKANVLETFQFWKDIVTEVGKEYPDVELSHMYVDNAAMQLVKAPKNFDVI 266 KR K++CSV KANVLET + W++I E+GKEYPDVELSHMYVDNAAMQLV+APK FDVI Sbjct: 180 QKRSKKVCSVGKANVLETTELWREIFEEIGKEYPDVELSHMYVDNAAMQLVRAPKQFDVI 239 Query: 267 VTGNMFGDILSDAAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGIANPLATIL 326 TGN+FGDILSD A+MLTGSIGMLPSASLD N KGLYEPSHGSAPDIAG+ ANPLAT+L Sbjct: 240 ATGNIFGDILSDEASMLTGSIGMLPSASLDENGKGLYEPSHGSAPDIAGQNKANPLATVL 299 Query: 327 SAAMMLRFSLNKAEQADRIENAVKKVLAQGLRTADIYEEGCTKVNTQQMGEAVVKAL 383 S AM+LR+SLN +A ++ENAV+KVL QGLRT DIYEEG V+ +MG+AV+ L Sbjct: 300 SLAMLLRYSLNDEARAQQVENAVQKVLQQGLRTGDIYEEGTKLVSCSEMGDAVLATL 356 >PA3118 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase Pae Pseudomonas aeruginosa Length = 360 Score = 469 bits (1207), Expect = e-132, Method: Compositional matrix adjust. Identities = 234/359 (65%), Positives = 279/359 (77%), Gaps = 9/359 (2%) Query: 29 KIAILPGDGIGPEIVNEAVRVLNALDEKF----EMETAPVGGAGYEAHGHPLPDGTLKLA 84 +I +LPGDGIGPEI+ EAV+VL +++F E+ +GGA + HG PL D TL+ A Sbjct: 4 QILVLPGDGIGPEIMAEAVKVLELANDRFQLGFELAEDVIGGAAIDKHGVPLADQTLQRA 63 Query: 85 KEADAILFGAVGDWKYDKLERALRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPE 144 ++ADA+L GAVG K+D++ER +RPE+ +L +R L LFAN RPAI YP+L ASSLKPE Sbjct: 64 RQADAVLLGAVGGPKWDRIERDIRPERGLLKIRSQLGLFANLRPAILYPQLAAASSLKPE 123 Query: 145 LVANLDILIVRELNGDIYFGQPRGXMREAPDGPFKGAREGFDTMRYSEPEIRRIAHVAFQ 204 +VA LDILIVREL G IYFGQPR R +G R+ +DT+ YSE EIRRIA V F Sbjct: 124 VVAGLDILIVRELTGGIYFGQPR-EQRVLENG----ERQAYDTLPYSESEIRRIARVGFD 178 Query: 205 AAAKRGKRLCSVDKANVLETFQFWKDIVTEVGKEYPDVELSHMYVDNAAMQLVKAPKNFD 264 A R RLCSVDKANVL + Q W+++V EV K+YPDVELSHMYVDNAAMQLV+APK FD Sbjct: 179 MARVRNNRLCSVDKANVLASSQLWREVVEEVAKDYPDVELSHMYVDNAAMQLVRAPKQFD 238 Query: 265 VIVTGNMFGDILSDAAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGIANPLAT 324 V+VT NMFGDILSD A+MLTGSIGMLPSASLDANNKG+YEP HGSAPDIAG+GIANPLAT Sbjct: 239 VMVTDNMFGDILSDEASMLTGSIGMLPSASLDANNKGMYEPCHGSAPDIAGQGIANPLAT 298 Query: 325 ILSAAMMLRFSLNKAEQADRIENAVKKVLAQGLRTADIYEEGCTKVNTQQMGEAVVKAL 383 ILS +MMLR+S ++A AD IE AV KVL QGLRT DI+ EGC KV T++MG+AVV AL Sbjct: 299 ILSVSMMLRYSFSQATAADAIEQAVSKVLDQGLRTGDIWSEGCRKVGTREMGDAVVAAL 357 >XF2372 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase Xfa Xylella fastidiosa 9a5c Length = 357 Score = 444 bits (1141), Expect = e-124, Method: Compositional matrix adjust. Identities = 225/359 (62%), Positives = 268/359 (74%), Gaps = 9/359 (2%) Query: 29 KIAILPGDGIGPEIVNEAVRVLNALDEK----FEMETAPVGGAGYEAHGHPLPDGTLKLA 84 +I ILPGDGIG EIV EAV+VL ++ + + +GGA YE +G PL D TL A Sbjct: 4 QILILPGDGIGHEIVAEAVKVLEHVNVRHTLNLRLSFDALGGAAYEKYGSPLADETLARA 63 Query: 85 KEADAILFGAVGDWKYDKLERALRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPE 144 ++ADA+L GAVG ++D ++ ALRPE+ +L +R L LFAN RPA+ YP+L AS+LKPE Sbjct: 64 RDADAVLLGAVGGPQWDTIDPALRPERGLLKIRAQLGLFANLRPALLYPQLADASTLKPE 123 Query: 145 LVANLDILIVRELNGDIYFGQPRGXMREAPDGPFKGAREGFDTMRYSEPEIRRIAHVAFQ 204 +VA LDILIVREL G +YFGQPRG G RE FDT+ Y E EIRRI V F+ Sbjct: 124 VVAGLDILIVRELTGGLYFGQPRGSRISK-----NGEREAFDTLPYCESEIRRILKVGFE 178 Query: 205 AAAKRGKRLCSVDKANVLETFQFWKDIVTEVGKEYPDVELSHMYVDNAAMQLVKAPKNFD 264 A RGK+LCSVDKANVL + Q W+ + E+ K+YPDV LSHMYVDNAAMQLV+ PK FD Sbjct: 179 MARLRGKKLCSVDKANVLASSQLWRTVAGEMAKDYPDVTLSHMYVDNAAMQLVRHPKQFD 238 Query: 265 VIVTGNMFGDILSDAAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGIANPLAT 324 VIVT NMFGDILSD A+MLTGSIGMLPSASLDANNKG+YEP HGSAPDIAG+G+ANPLAT Sbjct: 239 VIVTENMFGDILSDQASMLTGSIGMLPSASLDANNKGMYEPCHGSAPDIAGQGVANPLAT 298 Query: 325 ILSAAMMLRFSLNKAEQADRIENAVKKVLAQGLRTADIYEEGCTKVNTQQMGEAVVKAL 383 ILS AM+LR+S+ + AD IE+AV VL GLRTADI+ EG TKV T MG+AVV AL Sbjct: 299 ILSVAMLLRYSMGHIKTADAIEHAVGVVLDSGLRTADIWSEGMTKVGTVAMGDAVVAAL 357