BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0003.0017.p (473 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp1278 [GEPR] COG0477 Permeases of the major facilitator superf... 403 e-112 PA0458 [GEPR] COG0477 Permeases of the major facilitator superfa... 369 e-102 STM3887 [GEPR] COG0477 Permeases of the major facilitator superf... 362 1e-99 STM2129 [GEPR] COG0477 Permeases of the major facilitator superf... 355 1e-97 YPO2850 [GEPR] COG0477 Permeases of the major facilitator superf... 351 2e-96 >RSp1278 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 476 Score = 403 bits (1036), Expect = e-112, Method: Compositional matrix adjust. Identities = 239/459 (52%), Positives = 311/459 (67%), Gaps = 13/459 (2%) Query: 18 ASINDPVTQRALLWIVASGFFMQTLDTTIVNTALPAMARSLGEPVLNMHPVVVAYTLTMA 77 AS++ + + LLW+VA G FMQTLD TIVNTALPAMARSL E L M V++AYTLT A Sbjct: 5 ASVDKSL--QPLLWLVAVGLFMQTLDATIVNTALPAMARSLSESPLQMQSVIIAYTLTTA 62 Query: 78 SLTPASGWLADRFGTRRMYFAAILLFSLGSLLCAMASSLPMLLAARVVQGLGGSMLLPVG 137 L PASGWLADRFGTRRM+FAAI LFS+GSLLCA + +L ML+ ARVVQG+GG++L+PVG Sbjct: 63 MLMPASGWLADRFGTRRMFFAAIFLFSVGSLLCAESRTLTMLIVARVVQGVGGALLMPVG 122 Query: 138 RLAVLRAVPGAQYIAALASISIAGQLGPVVGPVLGGWLVESLSWHWIFLINLPVGVLGMG 197 RL VLR VP Q++ A++ ++I G +GP++GP LGGWLVE++SWHWIFLINLPVGV+G Sbjct: 123 RLTVLRVVPREQFLPAMSFVTIPGLIGPLIGPTLGGWLVEAVSWHWIFLINLPVGVVGAL 182 Query: 198 AVLYFLPD---DSLAGTPRFDLLGCVLLSACMVAFSLALDVPFD---SHRTGWSITLFVV 251 L +PD D+ FD G ++L+ M + S +LD D T + +F + Sbjct: 183 VTLKVMPDVRGDAADAADAFDWAGYLMLAFGMASVSFSLDGLSDLGFRRATVLVLLMFGL 242 Query: 252 AALTVLGYWRHASVHPRPLFRLGLFGEPNFSIGLAGNLVCRIGSSAVPFLLPLLLQVRLG 311 AALT YW HA + LF LF P+FS+G+ GNL RIG+ +PFL+PLLLQV LG Sbjct: 243 AALT--AYWLHAGRAKQALFPRALFAIPSFSVGILGNLFARIGAGGMPFLIPLLLQVGLG 300 Query: 312 YSPLHAGMVLLPAAIAGTIAKPWIAPLVKRFGYDRFLLVNTAIVGAAIMSFALITPDWPL 371 YSP+ AG++++P A+AG AKP LVKR GY L NT ++G I+SFAL +P PL Sbjct: 301 YSPMQAGLMMVPVAVAGMAAKPLGTWLVKRHGYRHMLFGNTLLLGLMIVSFALSSPQEPL 360 Query: 372 TAAIVQLAIFGASNSMQFAAMNSVTLKGLDKRDAGSGNSLFSMVQMLAIGLGVTIGGTMV 431 IVQLA FG NSMQF +MN++TL+ L A +GNS+ SMV ML++ LGV G ++ Sbjct: 361 WLRIVQLAAFGTFNSMQFTSMNALTLRDLSGAQASAGNSMLSMVMMLSMSLGVAAAGALL 420 Query: 432 NLFKSEAG---TATNASFQITFAIVGAITLASAWVFRKM 467 N F AG T +F + +G IT A+ W+F ++ Sbjct: 421 NGFSEYAGGQPADTLGAFHKAYICLGLITTAAGWIFAQL 459 >PA0458 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 477 Score = 369 bits (948), Expect = e-102, Method: Compositional matrix adjust. Identities = 213/464 (45%), Positives = 291/464 (62%), Gaps = 16/464 (3%) Query: 23 PVTQRALLWIVASGFFMQTLDTTIVNTALPAMARSLGEPVLNMHPVVVAYTLTMASLTPA 82 P R L W+VA FFMQ LD TI+NTALP+MA SL E L M VV+AY LT+A L PA Sbjct: 9 PRIARQLPWLVAVAFFMQALDGTILNTALPSMASSLNENPLRMQAVVIAYLLTVALLIPA 68 Query: 83 SGWLADRFGTRRMYFAAILLFSLGSLLCAMASSLPMLLAARVVQGLGGSMLLPVGRLAVL 142 SGW+ADRFGTRR++ A+LLFSLGSLLCA++ SL +L+ AR+VQG+GG++++PVGRL +L Sbjct: 69 SGWIADRFGTRRVFLGAVLLFSLGSLLCALSPSLELLVGARIVQGVGGALMMPVGRLVIL 128 Query: 143 RAVPGAQYIAALASISIAGQLGPVVGPVLGGWLVESLSWHWIFLINLPVGVLGMGAVLYF 202 R P + L+ ++I G LGP+ GP LGGWLVE SWHWIFLINLPVG+LG + Sbjct: 129 RVYPRQDLVRVLSFVTIPGLLGPLAGPTLGGWLVEYASWHWIFLINLPVGLLGCLVAMKL 188 Query: 203 LPDDSLAGTPRFDLLGCVLLSACMVAFSLALDVPFDSHRTGWSITLFVVAALTVL-GYWR 261 +PD RFD +G +L MV S+AL+ + H + + L ++ L +L YW Sbjct: 189 MPDLRSPVPSRFDSIGFLLFGGSMVLISIALEGLGELHLSHLRVVLLLIGGLVLLTAYWL 248 Query: 262 HASVHPRPLFRLGLFGEPNFSIGLAGNLVCRIGSSAVPFLLPLLLQVRLGYSPLHAGMVL 321 A +PLF LF F++G+ GNL R+GS A+PFL PLLLQV LGY P AGM + Sbjct: 249 RALRIDKPLFPPSLFKARTFAVGILGNLFARLGSGALPFLTPLLLQVGLGYPPSTAGMTM 308 Query: 322 LPAAIAGTIAKPWIAPLVKRFGYDRFLLVNTAIVGAAIMSFALITPDWPLTAAIVQLAIF 381 +P A+ +AKP PL+ FGY + L+ NT I+G I F L+ D P ++ L++ Sbjct: 309 IPLALFAMVAKPMAKPLLDFFGYRKLLVGNTLILGCLIAGFGLVDQDTPYVWLLLHLSLL 368 Query: 382 GASNSMQFAAMNSVTLKGLDKRDAGSGNSLFSMVQMLAIGLGVTIGGTMVNLFKSEAGTA 441 GA NS+QF AMN++TL L +A SGNSL S+V L+I LGV ++ F+++ T Sbjct: 369 GAVNSLQFTAMNTLTLIDLQDSNASSGNSLMSVVVQLSISLGVACAAALLGGFQTDLDTG 428 Query: 442 TN---ASFQITFAIVGAITLASAWVF------------RKMDPR 470 + +F T+ VG +++ +A +F R++DP Sbjct: 429 QDTVLGAFHATYVSVGLMSMLAAAIFFQLGSEDGRTSPRRVDPE 472 >STM3887 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 475 Score = 362 bits (929), Expect = 1e-99, Method: Compositional matrix adjust. Identities = 196/437 (44%), Positives = 279/437 (63%), Gaps = 6/437 (1%) Query: 31 WIVASGFFMQTLDTTIVNTALPAMARSLGEPVLNMHPVVVAYTLTMASLTPASGWLADRF 90 WI A FFMQ LD TI+NTALPA+A SL L M +++YTLT+A L P SGWLADRF Sbjct: 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRF 73 Query: 91 GTRRMYFAAILLFSLGSLLCAMASSLPMLLAARVVQGLGGSMLLPVGRLAVLRAVPGAQY 150 GTRR++ A+ LF+LGSL CA++SSL L+ RVVQG+GG+M++PV RLA+LRA P ++ Sbjct: 74 GTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSEL 133 Query: 151 IAALASISIAGQLGPVVGPVLGGWLVESLSWHWIFLINLPVGVLGMGAVLYFLPDDSLAG 210 + L +++ G +GP++GPVLGG LV SWHWIFLIN+P+GV G+ ++P+ + Sbjct: 134 LPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGILYARKYMPNFT--- 190 Query: 211 TPR--FDLLGCVLLSACMVAFSLALDVPFDSHRTGWSITLFVVAALT-VLGYWRHASVHP 267 TPR FD+ G L +V FS +++ + W + + ++ +L Y RHA HP Sbjct: 191 TPRRKFDMTGFFLFGLSLVLFSSGMELFGEKIVATWIASAIIFCSIVLLLAYIRHARRHP 250 Query: 268 RPLFRLGLFGEPNFSIGLAGNLVCRIGSSAVPFLLPLLLQVRLGYSPLHAGMVLLPAAIA 327 PL L LF FS+G+AGNL R+G+ VPFL+PL+LQV GY L AG ++ P A+ Sbjct: 251 TPLISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALG 310 Query: 328 GTIAKPWIAPLVKRFGYDRFLLVNTAIVGAAIMSFALITPDWPLTAAIVQLAIFGASNSM 387 IAK + +++R GY + L+ T +G I F+ +P P+ ++ L I G + S Sbjct: 311 SIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAQFSFQSPAMPIWMLVLPLFILGMAMST 370 Query: 388 QFAAMNSVTLKGLDKRDAGSGNSLFSMVQMLAIGLGVTIGGTMVNLFKSEAGTATNASFQ 447 QF AMN++TL L +A SGNS+ ++ Q L+I LGV I ++ +++ AGT+T F Sbjct: 371 QFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVLRIYEGFAGTSTVEQFH 430 Query: 448 ITFAIVGAITLASAWVF 464 TF +GAIT+ SA +F Sbjct: 431 YTFITMGAITIVSALMF 447 >STM2129 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 470 Score = 355 bits (912), Expect = 1e-97, Method: Compositional matrix adjust. Identities = 208/452 (46%), Positives = 290/452 (64%), Gaps = 12/452 (2%) Query: 23 PVTQRALLWIVASGFFMQTLDTTIVNTALPAMARSLGEPVLNMHPVVVAYTLTMASLTPA 82 P R LWIVA GFFMQ+LDTTIVNTALP+MA+SLGE L+MH VVV+Y LT+A + PA Sbjct: 5 PDNTRWQLWIVAFGFFMQSLDTTIVNTALPSMAKSLGESPLHMHMVVVSYVLTVAVMLPA 64 Query: 83 SGWLADRFGTRRMYFAAILLFSLGSLLCAMASSLPMLLAARVVQGLGGSMLLPVGRLAVL 142 SGWLAD+ G R ++FAAI+LF+LGSL CA++ +L L+ ARV+QG+GG+M++PVGRL V+ Sbjct: 65 SGWLADKIGVRNIFFAAIVLFTLGSLFCALSGTLNQLVLARVLQGVGGAMMVPVGRLTVM 124 Query: 143 RAVPGAQYIAALASISIAGQLGPVVGPVLGGWLVESLSWHWIFLINLPVGVLGMGAVLYF 202 + VP AQY+AA+ +++ GQ+GP++GP LGG LVE SWHWIFLIN+PVG++G A Sbjct: 125 KIVPRAQYMAAMTFVTLPGQIGPLLGPALGGVLVEYASWHWIFLINIPVGIVGAMATFML 184 Query: 203 LPDDSLAGTPRFDLLGCVLLSACMVAFSLALDVPFDSHRTGWS-ITLFVVAALTVLGYWR 261 +P + + T RFDL G +LL+ M +LALD + W+ L A +L Y Sbjct: 185 MP-NYIIETRRFDLPGFLLLAIGMAVLTLALDGSKSMGISPWTLAGLAAGGAAAILLYLF 243 Query: 262 HASVHPRPLFRLGLFGEPNFSIGLAGNLVCRIGSSAVPFLLPLLLQVRLGYSPLHAGMVL 321 HA + LF L LF P FS+GL G+ RIGS +PF+ P+ LQ+ LG+SP HAG+++ Sbjct: 244 HAKKNSGALFSLRLFRTPTFSLGLLGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMM 303 Query: 322 LPAAIAGTIAKPWIAPLVKRFGYDRFLLVNT---AIVGAAIMSFALITPDWPLTAAIVQL 378 +P + K + +V RFGY R L+ T A+V MS AL+ W + L Sbjct: 304 IPMVLGSMGMKRIVVQIVNRFGYRRVLVATTLGLALVSLLFMSVALL--GW-YYLLPLVL 360 Query: 379 AIFGASNSMQFAAMNSVTLKGLDKRDAGSGNSLFSMVQMLAIGLGVTIGGTMVNLFKSEA 438 + G NS +F++MN++TLK L A SGNSL SM+ L++ +GVTI G ++ +F + Sbjct: 361 LLQGMVNSARFSSMNTLTLKDLPDTLASSGNSLLSMIMQLSMSIGVTIAGMLLGMFGQQH 420 Query: 439 ----GTATNASFQITFAIVGAITLASAWVFRK 466 +AT+ F T+ + I A +F + Sbjct: 421 IGIDSSATHHVFMYTWLCMAVIIALPAIIFAR 452 >YPO2850 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 465 Score = 351 bits (901), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 203/468 (43%), Positives = 295/468 (63%), Gaps = 32/468 (6%) Query: 20 INDPVTQRALLWIVASGFFMQTLDTTIVNTALPAMARSLGEPVLNMHPVVVAYTLTMASL 79 + + R LWIVA GFFMQTLDTTIVNTALP++A SLGE L M V+V+Y LT+A + Sbjct: 2 VTQATSVRWQLWIVAFGFFMQTLDTTIVNTALPSIAASLGENPLRMQSVIVSYVLTVAVM 61 Query: 80 TPASGWLADRFGTRRMYFAAILLFSLGSLLCAMASSLPMLLAARVVQGLGGSMLLPVGRL 139 PASGWLADR G + ++F+AI+LF+ GSL+CA +++L L+ +RV+QG+GG+M++PVGRL Sbjct: 62 LPASGWLADRIGVKWVFFSAIILFTFGSLMCAQSATLNELILSRVLQGVGGAMMVPVGRL 121 Query: 140 AVLRAVPGAQYIAALASISIAGQLGPVVGPVLGGWLVESLSWHWIFLINLPVGVLGMGAV 199 V++ VP QY+AA+A +++ GQ+GP+VGP LGG+LVE SWHWIFLINLPVGV+G A Sbjct: 122 TVMKIVPREQYMAAMAFVTLPGQIGPLVGPALGGFLVEFASWHWIFLINLPVGVIGALAT 181 Query: 200 LYFLPDDSLAGTPRFDLLGCVLLSACMVAFSLALDVPFDSHRTGWSITLFVVAALTVLG- 258 L +P+ ++ T RFD+ G ++L+ M +LALD TG ++ +A L + G Sbjct: 182 LLLMPNHKMS-TRRFDISGFIMLAIGMATLTLALD-----GHTGLGLSPLAIAGLILCGV 235 Query: 259 -----YWRHASVHPRPLFRLGLFGEPNFSIGLAGNLVCRIGSSAVPFLLPLLLQVRLGYS 313 YW HA + LF L LF +++GL G++ RIGS +PF+ P+ LQ+ LG+S Sbjct: 236 IALGSYWWHALGNRFALFSLHLFKNKIYTLGLVGSMSARIGSGMLPFMTPIFLQIGLGFS 295 Query: 314 PLHAGMVLLPAAIAGTIAKPWIAPLVKRFGYDRFLLVNTAIVG--------AAIMSFALI 365 P HAG++++P I K I +V RFGY R L+ T ++ AIM + L+ Sbjct: 296 PFHAGLMMIPMIIGSMGMKRIIVQVVNRFGYRRVLVNATLLLAVVSLSLPLVAIMGWTLL 355 Query: 366 TPDWPLTAAIVQLAIFGASNSMQFAAMNSVTLKGLDKRDAGSGNSLFSMVQMLAIGLGVT 425 P V L G N+++F+ MN++TLK L R A SGNSL SM L++ +GV+ Sbjct: 356 MP--------VVLFFQGMLNALRFSTMNTLTLKTLPDRLASSGNSLLSMAMQLSMSIGVS 407 Query: 426 IGGTMVNLF-KSEAGT---ATNASFQITFAIVGAITLASAWVFRKMDP 469 G ++ F + T AT+++F ++ + I A +F ++ P Sbjct: 408 TAGILLGTFAHHQVATNTPATHSAFLYSYLCMAIIIALPALIFNRVPP 455