BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0036.0005.p (219 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003777183.1| thiopurine S-methyltransferase [Herbaspirill... 439 e-121 ref|NP_879683.1| thiopurine S-methyltransferase [Bordetella pert... 325 2e-87 ref|NP_884416.1| thiopurine S-methyltransferase [Bordetella para... 325 4e-87 gb|EFV87718.1| thiopurine S-methyltransferase [Achromobacter xyl... 312 3e-83 ref|YP_004418773.1| thiopurine S-methyltransferase [Pusillimonas... 307 9e-82 ref|YP_001632454.1| thiopurine S-methyltransferase [Bordetella p... 306 1e-81 gb|EGP47985.1| thiopurine S-methyltransferase [Achromobacter xyl... 306 2e-81 ref|ZP_06689288.1| thiopurine S-methyltransferase [Achromobacter... 304 7e-81 ref|YP_003980893.1| methyltransferase [Achromobacter xylosoxidan... 298 4e-79 ref|YP_785541.1| thiopurine S-methyltransferase [Bordetella aviu... 280 1e-73 >ref|YP_003777183.1| thiopurine S-methyltransferase [Herbaspirillum seropedicae SmR1] gb|ADJ65275.1| thiopurine S-methyltransferase protein [Herbaspirillum seropedicae SmR1] Length = 219 Score = 439 bits (1129), Expect = e-121, Method: Compositional matrix adjust. Identities = 216/218 (99%), Positives = 216/218 (99%) Query: 1 MEAEFWLERWRDGRTHFHQSRVTPLLQKYWLSLALPAGSTVLVPLCGKSLDMLWLAEQGH 60 MEAEFWLERWRDGRTHFHQSRVTPLLQKYW SLALPAGSTVLVPLCGKSLDMLWLAEQGH Sbjct: 1 MEAEFWLERWRDGRTHFHQSRVTPLLQKYWPSLALPAGSTVLVPLCGKSLDMLWLAEQGH 60 Query: 61 RVLGVELSELAITQFFSEHQLVPLVHESAQGRHYAAGNIELICGDIFALEEATLAACAGA 120 RVLGVELSELAITQFFSEHQLVPLVHESAQGRHY AGNIELICGDIFALEEATLAACAGA Sbjct: 61 RVLGVELSELAITQFFSEHQLVPLVHESAQGRHYVAGNIELICGDIFALEEATLAACAGA 120 Query: 121 YDRAALIALPPAMRARYVTEVYGRLPAQARSLLITLEYDQQKMDGPPFSVSEEEVLRLYA 180 YDRAALIALPPAMRARYVTEVYGRLPAQARSLLITLEYDQQKMDGPPFSVSEEEVLRLYA Sbjct: 121 YDRAALIALPPAMRARYVTEVYGRLPAQARSLLITLEYDQQKMDGPPFSVSEEEVLRLYA 180 Query: 181 PHSEAQAIDRRDILDKEPKFLERGLSALETVVYRLQRR 218 PHSEAQAIDRRDILDKEPKFLERGLSALETVVYRLQRR Sbjct: 181 PHSEAQAIDRRDILDKEPKFLERGLSALETVVYRLQRR 218 >ref|NP_879683.1| thiopurine S-methyltransferase [Bordetella pertussis Tohama I] sp|Q7VZM5.1|TPMT_BORPE RecName: Full=Thiopurine S-methyltransferase; AltName: Full=Thiopurine methyltransferase emb|CAE41176.1| thiopurine S-methyltransferase [Bordetella pertussis Tohama I] gb|AEE66302.1| thiopurine S-methyltransferase [Bordetella pertussis CS] Length = 219 Score = 325 bits (834), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 153/217 (70%), Positives = 183/217 (84%) Query: 1 MEAEFWLERWRDGRTHFHQSRVTPLLQKYWLSLALPAGSTVLVPLCGKSLDMLWLAEQGH 60 M+A+FWL+RWR+GRTHFHQ+RVTPLLQKYW +L +PAG VLVPL GKSLDM+WLA QG Sbjct: 1 MDADFWLDRWREGRTHFHQTRVTPLLQKYWPTLDVPAGGQVLVPLAGKSLDMVWLAGQGL 60 Query: 61 RVLGVELSELAITQFFSEHQLVPLVHESAQGRHYAAGNIELICGDIFALEEATLAACAGA 120 RVLGVELS+LA+ QFF E+ L P +H+SAQGRHY AGN+ELICGD+FALE+ATLAACAG Sbjct: 61 RVLGVELSQLAVEQFFDENDLRPEIHQSAQGRHYVAGNLELICGDVFALEDATLAACAGV 120 Query: 121 YDRAALIALPPAMRARYVTEVYGRLPAQARSLLITLEYDQQKMDGPPFSVSEEEVLRLYA 180 YDRAAL+ALP MR RY EVYGRL R +LITL+Y Q +M+GPPFSV + EV LYA Sbjct: 121 YDRAALVALPEPMRKRYAREVYGRLGRGCRGILITLDYPQDQMEGPPFSVDDAEVQALYA 180 Query: 181 PHSEAQAIDRRDILDKEPKFLERGLSALETVVYRLQR 217 H+EA+ IDRRDILDKEPKF +RG++ L+T+VYRL+R Sbjct: 181 GHTEARLIDRRDILDKEPKFNQRGVARLDTLVYRLER 217 >ref|NP_884416.1| thiopurine S-methyltransferase [Bordetella parapertussis 12822] ref|NP_888102.1| thiopurine S-methyltransferase [Bordetella bronchiseptica RB50] sp|Q7W8H4.1|TPMT_BORPA RecName: Full=Thiopurine S-methyltransferase; AltName: Full=Thiopurine methyltransferase sp|Q7WM36.1|TPMT_BORBR RecName: Full=Thiopurine S-methyltransferase; AltName: Full=Thiopurine methyltransferase emb|CAE32054.1| thiopurine S-methyltransferase [Bordetella bronchiseptica RB50] emb|CAE37460.1| thiopurine S-methyltransferase [Bordetella parapertussis] Length = 219 Score = 325 bits (832), Expect = 4e-87, Method: Compositional matrix adjust. Identities = 153/217 (70%), Positives = 183/217 (84%) Query: 1 MEAEFWLERWRDGRTHFHQSRVTPLLQKYWLSLALPAGSTVLVPLCGKSLDMLWLAEQGH 60 M+A+FWL+RWR+GRTHFHQ+RVTPLLQKYW +L +PAG VLVPL GKSLDM+WLA QG Sbjct: 1 MDADFWLDRWREGRTHFHQTRVTPLLQKYWPALDVPAGGQVLVPLAGKSLDMVWLAGQGL 60 Query: 61 RVLGVELSELAITQFFSEHQLVPLVHESAQGRHYAAGNIELICGDIFALEEATLAACAGA 120 RVLGVELS+LA+ QFF E+ L P +H+SAQGRHY AGN+ELICGD+FALE+ATLAACAG Sbjct: 61 RVLGVELSQLAVEQFFDENGLRPEIHQSAQGRHYVAGNLELICGDVFALEDATLAACAGV 120 Query: 121 YDRAALIALPPAMRARYVTEVYGRLPAQARSLLITLEYDQQKMDGPPFSVSEEEVLRLYA 180 YDRAAL+ALP MR RY EVYGRL R +LITL+Y Q +M+GPPFSV + EV LYA Sbjct: 121 YDRAALVALPEPMRKRYAREVYGRLGRGCRGILITLDYPQDQMEGPPFSVDDAEVQALYA 180 Query: 181 PHSEAQAIDRRDILDKEPKFLERGLSALETVVYRLQR 217 H+EA+ IDRRDILDKEPKF +RG++ L+T+VYRL+R Sbjct: 181 GHTEARLIDRRDILDKEPKFNQRGVARLDTLVYRLER 217 >gb|EFV87718.1| thiopurine S-methyltransferase [Achromobacter xylosoxidans C54] Length = 219 Score = 312 bits (799), Expect = 3e-83, Method: Compositional matrix adjust. Identities = 147/215 (68%), Positives = 176/215 (81%) Query: 1 MEAEFWLERWRDGRTHFHQSRVTPLLQKYWLSLALPAGSTVLVPLCGKSLDMLWLAEQGH 60 M+AEFWLERWRDGRTHFHQ+RVTPLLQKYW +L++PAG VLVPLCGKSLDM+WLA QG+ Sbjct: 1 MDAEFWLERWRDGRTHFHQTRVTPLLQKYWPTLSVPAGGKVLVPLCGKSLDMVWLAAQGY 60 Query: 61 RVLGVELSELAITQFFSEHQLVPLVHESAQGRHYAAGNIELICGDIFALEEATLAACAGA 120 +VLGVELS+LA+ QFF+E++L P++HESA GRHY AGNIE+ICGDIF L+ L+ C GA Sbjct: 61 QVLGVELSQLAVEQFFTENELKPVIHESAYGRHYVAGNIEIICGDIFKLDAPLLSHCVGA 120 Query: 121 YDRAALIALPPAMRARYVTEVYGRLPAQARSLLITLEYDQQKMDGPPFSVSEEEVLRLYA 180 YDRAAL+ALP MR YV VYG+L R LLITL+Y Q++MDGPPF+V + E+ L+ Sbjct: 121 YDRAALVALPADMRGDYVRHVYGQLAPGYRGLLITLDYPQEEMDGPPFAVVDAEMRNLFT 180 Query: 181 PHSEAQAIDRRDILDKEPKFLERGLSALETVVYRL 215 S A IDRRDIL KEPKF ERG+S L+TVVYRL Sbjct: 181 GVSPAVIIDRRDILAKEPKFAERGVSRLDTVVYRL 215 >ref|YP_004418773.1| thiopurine S-methyltransferase [Pusillimonas sp. T7-7] gb|AEC22149.1| thiopurine S-methyltransferase [Pusillimonas sp. T7-7] Length = 221 Score = 307 bits (786), Expect = 9e-82, Method: Compositional matrix adjust. Identities = 147/216 (68%), Positives = 170/216 (78%) Query: 1 MEAEFWLERWRDGRTHFHQSRVTPLLQKYWLSLALPAGSTVLVPLCGKSLDMLWLAEQGH 60 ME +FWL RWRD +T FHQ RVTPLLQKYW SL P GS VLVPLCGKSLDM+WLAEQGH Sbjct: 1 MEPDFWLARWRDEQTGFHQQRVTPLLQKYWPSLERPKGSRVLVPLCGKSLDMIWLAEQGH 60 Query: 61 RVLGVELSELAITQFFSEHQLVPLVHESAQGRHYAAGNIELICGDIFALEEATLAACAGA 120 VLGVEL++ I QFF+E+ L VHE+ QG HY GNIELICGDIF + TLAAC G Sbjct: 61 EVLGVELAQQPIEQFFAENGLQATVHETLQGTHYRCGNIELICGDIFGISAETLAACQGV 120 Query: 121 YDRAALIALPPAMRARYVTEVYGRLPAQARSLLITLEYDQQKMDGPPFSVSEEEVLRLYA 180 YDRAAL+ALPPAMR RYV VYG+L Q R LL+TL+YDQ +M+GPPF+V++ EV LY Sbjct: 121 YDRAALVALPPAMRQRYVAHVYGQLAQQYRGLLLTLDYDQHEMEGPPFAVNDAEVQSLYT 180 Query: 181 PHSEAQAIDRRDILDKEPKFLERGLSALETVVYRLQ 216 HS AQ ID+R ILDKEPKF ERGL+ L+T+VYRL+ Sbjct: 181 GHSHAQLIDQRAILDKEPKFKERGLTRLDTLVYRLE 216 >ref|YP_001632454.1| thiopurine S-methyltransferase [Bordetella petrii DSM 12804] sp|A9I3K3.1|TPMT_BORPD RecName: Full=Thiopurine S-methyltransferase; AltName: Full=Thiopurine methyltransferase emb|CAP44186.1| thiopurine S-methyltransferase [Bordetella petrii] Length = 219 Score = 306 bits (785), Expect = 1e-81, Method: Compositional matrix adjust. Identities = 146/218 (66%), Positives = 172/218 (78%) Query: 1 MEAEFWLERWRDGRTHFHQSRVTPLLQKYWLSLALPAGSTVLVPLCGKSLDMLWLAEQGH 60 M+AEFWLERWRDGRTHFHQ RVTPLL KYW +L LP G VLVPLCGK+LDM+WLA+QGH Sbjct: 1 MDAEFWLERWRDGRTHFHQQRVTPLLAKYWPTLQLPPGCRVLVPLCGKTLDMVWLAQQGH 60 Query: 61 RVLGVELSELAITQFFSEHQLVPLVHESAQGRHYAAGNIELICGDIFALEEATLAACAGA 120 +VLGVELS LA+ QFF+E+ L V E+ G +Y+AG+I + CGDIF L L C GA Sbjct: 61 QVLGVELSSLAVEQFFAENGLQATVREAGPGTYYSAGDISIYCGDIFDLGADVLGDCVGA 120 Query: 121 YDRAALIALPPAMRARYVTEVYGRLPAQARSLLITLEYDQQKMDGPPFSVSEEEVLRLYA 180 +DRAAL+ALP AMR RY VYG+L A R LLITL+YDQ +MDGPPFSV ++EV +YA Sbjct: 121 FDRAALVALPAAMRPRYARHVYGQLSAAYRGLLITLDYDQSQMDGPPFSVRDDEVQAIYA 180 Query: 181 PHSEAQAIDRRDILDKEPKFLERGLSALETVVYRLQRR 218 HSEA IDRRDIL KEPKF ERGL+ L+T+VYRLQR+ Sbjct: 181 GHSEAVLIDRRDILSKEPKFAERGLTQLDTLVYRLQRQ 218 >gb|EGP47985.1| thiopurine S-methyltransferase [Achromobacter xylosoxidans AXX-A] Length = 219 Score = 306 bits (783), Expect = 2e-81, Method: Compositional matrix adjust. Identities = 145/215 (67%), Positives = 174/215 (80%) Query: 1 MEAEFWLERWRDGRTHFHQSRVTPLLQKYWLSLALPAGSTVLVPLCGKSLDMLWLAEQGH 60 M+AEFWLERWRDGRTHFHQ+RVTPLLQKYW +L++PAG VLVPLCGKSLDM+WLA QG Sbjct: 1 MDAEFWLERWRDGRTHFHQARVTPLLQKYWPTLSVPAGGKVLVPLCGKSLDMVWLAAQGF 60 Query: 61 RVLGVELSELAITQFFSEHQLVPLVHESAQGRHYAAGNIELICGDIFALEEATLAACAGA 120 +VLGVELS+LA+ QFF E++L P++ +SA GRHY AGNIE+ICGDIF L+ L+ C GA Sbjct: 61 QVLGVELSQLAVEQFFVENELKPVIQDSAYGRHYVAGNIEIICGDIFKLDAPLLSHCVGA 120 Query: 121 YDRAALIALPPAMRARYVTEVYGRLPAQARSLLITLEYDQQKMDGPPFSVSEEEVLRLYA 180 YDRAAL+ALP MR YV VYG+L R LLITL+Y Q++MDGPPF+V + E+ L++ Sbjct: 121 YDRAALVALPVEMRGEYVRHVYGQLSPGYRGLLITLDYPQEEMDGPPFAVVDAEMRALFS 180 Query: 181 PHSEAQAIDRRDILDKEPKFLERGLSALETVVYRL 215 S A IDRRDIL KEPKF ERG+S L+TVVYRL Sbjct: 181 GVSPAVIIDRRDILTKEPKFAERGVSRLDTVVYRL 215 >ref|ZP_06689288.1| thiopurine S-methyltransferase [Achromobacter piechaudii ATCC 43553] gb|EFF73807.1| thiopurine S-methyltransferase [Achromobacter piechaudii ATCC 43553] Length = 220 Score = 304 bits (778), Expect = 7e-81, Method: Compositional matrix adjust. Identities = 142/215 (66%), Positives = 173/215 (80%) Query: 1 MEAEFWLERWRDGRTHFHQSRVTPLLQKYWLSLALPAGSTVLVPLCGKSLDMLWLAEQGH 60 M+AEFWLERWR+GRTHFHQ+R+TPLLQKYW +LA+P G VLVPLCGKSLDM+WLA QGH Sbjct: 1 MDAEFWLERWREGRTHFHQTRITPLLQKYWPTLAVPKGGRVLVPLCGKSLDMVWLAAQGH 60 Query: 61 RVLGVELSELAITQFFSEHQLVPLVHESAQGRHYAAGNIELICGDIFALEEATLAACAGA 120 VLG+ELS+LA+ QFFSE++L P+ HES G+HY AGNIE+ICGDIF L+ L+ C GA Sbjct: 61 TVLGIELSQLAVEQFFSENELRPVTHESLYGKHYVAGNIEIICGDIFKLDSQVLSHCVGA 120 Query: 121 YDRAALIALPPAMRARYVTEVYGRLPAQARSLLITLEYDQQKMDGPPFSVSEEEVLRLYA 180 YDRAAL+ALP MRA YV VYG+L +R LLITL+Y Q++M GPPF+V + EV +++ Sbjct: 121 YDRAALVALPEEMRAAYVRHVYGQLSPASRGLLITLDYPQEEMAGPPFAVLDSEVQAIFS 180 Query: 181 PHSEAQAIDRRDILDKEPKFLERGLSALETVVYRL 215 + A IDRRDILDKEPKF G+S L+TVVYRL Sbjct: 181 GVAPAVIIDRRDILDKEPKFQSAGVSRLDTVVYRL 215 >ref|YP_003980893.1| methyltransferase [Achromobacter xylosoxidans A8] gb|ADP18178.1| thiopurine S-methyltransferase [Achromobacter xylosoxidans A8] Length = 219 Score = 298 bits (763), Expect = 4e-79, Method: Compositional matrix adjust. Identities = 142/215 (66%), Positives = 169/215 (78%) Query: 1 MEAEFWLERWRDGRTHFHQSRVTPLLQKYWLSLALPAGSTVLVPLCGKSLDMLWLAEQGH 60 M+AEFWLERWR+GRTHFHQSRVTPLLQKYW +L +P VLVPLCGKSLDM+W+A QGH Sbjct: 1 MDAEFWLERWREGRTHFHQSRVTPLLQKYWPTLGVPKDGRVLVPLCGKSLDMVWIAAQGH 60 Query: 61 RVLGVELSELAITQFFSEHQLVPLVHESAQGRHYAAGNIELICGDIFALEEATLAACAGA 120 VLGVELS+LA+ QFF E++L PL H S G+HY AG+IE+ICGDIF L+ L+ C GA Sbjct: 61 SVLGVELSQLAVEQFFEENELKPLTHVSVYGKHYVAGSIEIICGDIFKLDAQLLSHCVGA 120 Query: 121 YDRAALIALPPAMRARYVTEVYGRLPAQARSLLITLEYDQQKMDGPPFSVSEEEVLRLYA 180 YDRAAL+ALP AMRA YV VYG L + LLITL+Y Q++M GPPFSV + EV ++A Sbjct: 121 YDRAALVALPEAMRADYVRHVYGNLSPACQGLLITLDYPQEEMSGPPFSVVDSEVQAIFA 180 Query: 181 PHSEAQAIDRRDILDKEPKFLERGLSALETVVYRL 215 S A+ IDRRDIL+KEPKFL G+S L+TVVY L Sbjct: 181 GVSPARIIDRRDILEKEPKFLAAGVSRLDTVVYHL 215 >ref|YP_785541.1| thiopurine S-methyltransferase [Bordetella avium 197N] sp|Q2KV81.1|TPMT_BORA1 RecName: Full=Thiopurine S-methyltransferase; AltName: Full=Thiopurine methyltransferase emb|CAJ48627.1| thiopurine S-methyltransferase [Bordetella avium 197N] Length = 217 Score = 280 bits (715), Expect = 1e-73, Method: Compositional matrix adjust. Identities = 136/215 (63%), Positives = 163/215 (75%), Gaps = 2/215 (0%) Query: 1 MEAEFWLERWRDGRTHFHQSRVTPLLQKYWLSLALPAGSTVLVPLCGKSLDMLWLAEQGH 60 M+A+FWL+RWR+G+T FHQ RVTPLL KYW LALP G+ VLVPL GKSLDM+WLAEQGH Sbjct: 1 MDADFWLDRWREGKTGFHQDRVTPLLPKYWPRLALPTGARVLVPLAGKSLDMVWLAEQGH 60 Query: 61 RVLGVELSELAITQFFSEHQLVPLVHESAQGRHYAAGNIELICGDIFALEEATLAACAGA 120 VLGVELS LA+ QFF+E P ESA G+HYAA +ELICGDIF L++A L C G Sbjct: 61 EVLGVELSSLAVQQFFAEQGWAPRRWESAYGQHYAANGVELICGDIFKLDDAALKDCLGV 120 Query: 121 YDRAALIALPPAMRARYVTEVYGRLPAQARSLLITLEYDQQKMDGPPFSVSEEEVLRLYA 180 YDRAAL+ALP MR Y VYG++PA R LL+TL+Y Q +M+GPPFSV E EV L+ Sbjct: 121 YDRAALVALPETMRRAYANHVYGQMPAGYRGLLLTLDYPQTQMEGPPFSVDEAEVQALFG 180 Query: 181 PHSEAQAIDRRDILDKEPKFLERGLSALETVVYRL 215 +A DRRDIL+KEPKF ERG+S L+T+V+RL Sbjct: 181 --EQAHLWDRRDILEKEPKFAERGVSRLDTLVFRL 213