BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0035.0222.p (436 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003776430.1| 3-hydroxy-3-methylglutaryl-coenzyme A reduct... 867 0.0 ref|YP_004416465.1| HMG-CoA reductase [Pusillimonas sp. T7-7] >g... 638 0.0 ref|YP_001777654.1| hydroxymethylglutaryl-CoA reductase, degrada... 631 e-179 ref|YP_003909446.1| hydroxymethylglutaryl-CoA reductase, degrada... 630 e-178 ref|ZP_04942434.1| Hydroxymethylglutaryl-CoA reductase [Burkhold... 628 e-178 ref|YP_837137.1| hydroxymethylglutaryl-CoA reductase, degradativ... 627 e-177 ref|YP_002233154.1| 3-hydroxy-3-methylglutaryl-coenzyme A reduct... 625 e-177 ref|YP_004152417.1| hydroxymethylglutaryL-CoA reductase, degrada... 620 e-175 ref|YP_004348406.1| 3-hydroxy-3-methylglutaryl-coenzyme A reduct... 619 e-175 ref|ZP_08275680.1| Hydroxymethylglutaryl-CoA reductase [Oxalobac... 618 e-175 >ref|YP_003776430.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Herbaspirillum seropedicae SmR1] gb|ADJ64522.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase protein [Herbaspirillum seropedicae SmR1] Length = 436 Score = 867 bits (2239), Expect = 0.0, Method: Compositional matrix adjust. Identities = 432/436 (99%), Positives = 432/436 (99%) Query: 1 MSQDVHAGATPDSRLPGFRTYTPAQRLAEVGRLAQLDQAEQALLGQPGALPLATADGMIE 60 MSQDVHAGATPDSRLPGFRTYTPAQRLAEVGRLAQLDQAEQALLGQPGALPL TADGMIE Sbjct: 1 MSQDVHAGATPDSRLPGFRTYTPAQRLAEVGRLAQLDQAEQALLGQPGALPLGTADGMIE 60 Query: 61 NVVGSFQLPLGVAGYFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRACGGFQTSSSLPLM 120 NVVGSFQLPLGVAGYFQLNGRDVLVPMAVEEPSVVAAASFMAKLVR CGGFQTSSSLPLM Sbjct: 61 NVVGSFQLPLGVAGYFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRTCGGFQTSSSLPLM 120 Query: 121 RAQIQLTGISDPHGARLAILKERQAIIDIANSRDQLLQQLGGGCRDIEVQVFPDTRRGAM 180 RAQIQLTGISDPHGARLAILKERQAIIDIANSRDQLLQQLGGGCRDIEVQVFPDTRRGAM Sbjct: 121 RAQIQLTGISDPHGARLAILKERQAIIDIANSRDQLLQQLGGGCRDIEVQVFPDTRRGAM 180 Query: 181 VVTHLIVDVRDAMGANTVNTMAEAVAGHIERVTGGKVRLRILSNLADLRLARARVKVSAD 240 VVTHLIVDVRDAMGANTVNTMAEAVA HIERVTGGKVRLRILSNLADLRLARARVKVSAD Sbjct: 181 VVTHLIVDVRDAMGANTVNTMAEAVASHIERVTGGKVRLRILSNLADLRLARARVKVSAD 240 Query: 241 VLGTAQYRGEEVINGIVDAYELAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAH 300 VL TAQYRGEEVINGIVDAYELAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAH Sbjct: 241 VLSTAQYRGEEVINGIVDAYELAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAH 300 Query: 301 AYACRHGRYTSLTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARVALKILGVQSAQA 360 AYACRHGRYTSLTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARVALKILGVQSAQA Sbjct: 301 AYACRHGRYTSLTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARVALKILGVQSAQA 360 Query: 361 LAEVAVAVGLAQNMAALRALATEGIQRGHMALHARNIALAAGAEASEMDWLVQQMVARHD 420 LAEVAVAVGLAQNMAALRALATEGIQRGHMALHARNIALAAGAEASEMDWLVQQMVARHD Sbjct: 361 LAEVAVAVGLAQNMAALRALATEGIQRGHMALHARNIALAAGAEASEMDWLVQQMVARHD 420 Query: 421 VRVDYAKALLAERRRG 436 VRVDYAKALLAERRRG Sbjct: 421 VRVDYAKALLAERRRG 436 >ref|YP_004416465.1| HMG-CoA reductase [Pusillimonas sp. T7-7] gb|AEC19841.1| HMG-CoA reductase [Pusillimonas sp. T7-7] Length = 433 Score = 638 bits (1645), Expect = 0.0, Method: Compositional matrix adjust. Identities = 309/422 (73%), Positives = 362/422 (85%) Query: 12 DSRLPGFRTYTPAQRLAEVGRLAQLDQAEQALLGQPGALPLATADGMIENVVGSFQLPLG 71 DS LP FRT +P +RL + + QL Q ++ LL PGALPL TAD MIENV+G F+LP Sbjct: 4 DSSLPQFRTLSPDERLEHLAKKLQLSQEDRRLLAGPGALPLETADSMIENVIGKFELPYA 63 Query: 72 VAGYFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRACGGFQTSSSLPLMRAQIQLTGISD 131 VAGYFQ+NG+DVLVPMAVEEPSVVAAAS+MAKLVRA GGF TSSS P+MRAQ+Q+ + D Sbjct: 64 VAGYFQVNGKDVLVPMAVEEPSVVAAASYMAKLVRANGGFHTSSSGPIMRAQVQIVNLGD 123 Query: 132 PHGARLAILKERQAIIDIANSRDQLLQQLGGGCRDIEVQVFPDTRRGAMVVTHLIVDVRD 191 P+GAR AIL++RQ IIDIANSRDQ+L LGGGC+DIEV VFPDT RGAMVV HLIVDVRD Sbjct: 124 PYGARHAILQQRQDIIDIANSRDQVLMGLGGGCKDIEVHVFPDTARGAMVVVHLIVDVRD 183 Query: 192 AMGANTVNTMAEAVAGHIERVTGGKVRLRILSNLADLRLARARVKVSADVLGTAQYRGEE 251 AMGANTVNTMAEAVA +E++TGG+VRLRILSNLADLRLARA ++++ ++L T++Y G + Sbjct: 184 AMGANTVNTMAEAVAPRMEQITGGRVRLRILSNLADLRLARAHLRLTPELLQTSEYSGVD 243 Query: 252 VINGIVDAYELAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRHGRYTS 311 VI+GIVDAYE AAVDPYRAATHNKGIMNGIDP+IVATGNDWRAVEAGAHAYACRHGRYTS Sbjct: 244 VIDGIVDAYEFAAVDPYRAATHNKGIMNGIDPIIVATGNDWRAVEAGAHAYACRHGRYTS 303 Query: 312 LTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARVALKILGVQSAQALAEVAVAVGLA 371 L+ WE+A++G+LVGTLE+PMPVGLVGGATKTHP A+++LKIL V SAQ LAE+A AVGLA Sbjct: 304 LSTWEVASNGELVGTLEMPMPVGLVGGATKTHPLAQLSLKILNVASAQELAEIAAAVGLA 363 Query: 372 QNMAALRALATEGIQRGHMALHARNIALAAGAEASEMDWLVQQMVARHDVRVDYAKALLA 431 QN+AALRAL+TEGIQRGHMALHARNIAL AGA+ ++ W+ Q+MV DVR D A LL Sbjct: 364 QNLAALRALSTEGIQRGHMALHARNIALLAGAKGDDIAWVAQKMVEARDVRADLATELLQ 423 Query: 432 ER 433 + Sbjct: 424 NK 425 >ref|YP_001777654.1| hydroxymethylglutaryl-CoA reductase, degradative [Burkholderia cenocepacia MC0-3] gb|ACA93164.1| hydroxymethylglutaryl-CoA reductase, degradative [Burkholderia cenocepacia MC0-3] Length = 428 Score = 631 bits (1627), Expect = e-179, Method: Compositional matrix adjust. Identities = 312/425 (73%), Positives = 357/425 (84%) Query: 12 DSRLPGFRTYTPAQRLAEVGRLAQLDQAEQALLGQPGALPLATADGMIENVVGSFQLPLG 71 DS LP FR+ TP QRL+ + R+ LD AE ALL QPGALPL TA+GMIENV+G+F+LP+ Sbjct: 4 DSALPNFRSLTPEQRLSHLSRIVGLDDAEHALLAQPGALPLDTANGMIENVIGTFELPMA 63 Query: 72 VAGYFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRACGGFQTSSSLPLMRAQIQLTGISD 131 VAGYF++N RDV+VPMAVEEPS+VAAAS+MAKL RA GGF+TSSS PLMRAQ+Q+ G+ D Sbjct: 64 VAGYFRINDRDVIVPMAVEEPSIVAAASYMAKLSRAAGGFRTSSSGPLMRAQVQVIGVDD 123 Query: 132 PHGARLAILKERQAIIDIANSRDQLLQQLGGGCRDIEVQVFPDTRRGAMVVTHLIVDVRD 191 P+GARLAIL+ +I +ANSRD++L LGGGCRDIEV VFPDT RGAM+V HLIVDVRD Sbjct: 124 PYGARLAILRHAAELIALANSRDKVLVGLGGGCRDIEVHVFPDTPRGAMIVAHLIVDVRD 183 Query: 192 AMGANTVNTMAEAVAGHIERVTGGKVRLRILSNLADLRLARARVKVSADVLGTAQYRGEE 251 AMGANTVNTMAE VA IE +TGG+VRLRILSNLADLRLARA V+ SA L T Y GE Sbjct: 184 AMGANTVNTMAETVATRIEAITGGQVRLRILSNLADLRLARAEVRYSAATLATDDYAGEA 243 Query: 252 VINGIVDAYELAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRHGRYTS 311 VI+ ++DAY AA DPYRAATHNKGIMNGIDPV+VATGNDWRAVEAGAHAYA R GRYTS Sbjct: 244 VIDRVIDAYVFAATDPYRAATHNKGIMNGIDPVVVATGNDWRAVEAGAHAYASRSGRYTS 303 Query: 312 LTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARVALKILGVQSAQALAEVAVAVGLA 371 LT WE AA+GDLVGT+E+PMPVGLVGGATKTHP AR+ALKI+ V SAQ L E+AVAVGLA Sbjct: 304 LTTWEKAANGDLVGTIEMPMPVGLVGGATKTHPLARLALKIMNVTSAQELGEIAVAVGLA 363 Query: 372 QNMAALRALATEGIQRGHMALHARNIALAAGAEASEMDWLVQQMVARHDVRVDYAKALLA 431 QN+ ALRALATEGIQRGHMALHARNIA+AAGA +++D + QQMVA DVR D+A LLA Sbjct: 364 QNLGALRALATEGIQRGHMALHARNIAVAAGATGADIDRIAQQMVAAKDVRTDFAVELLA 423 Query: 432 ERRRG 436 R G Sbjct: 424 GRSGG 428 >ref|YP_003909446.1| hydroxymethylglutaryl-CoA reductase, degradative [Burkholderia sp. CCGE1003] gb|ADN60155.1| hydroxymethylglutaryl-CoA reductase, degradative [Burkholderia sp. CCGE1003] Length = 428 Score = 630 bits (1624), Expect = e-178, Method: Compositional matrix adjust. Identities = 305/424 (71%), Positives = 358/424 (84%) Query: 12 DSRLPGFRTYTPAQRLAEVGRLAQLDQAEQALLGQPGALPLATADGMIENVVGSFQLPLG 71 +S LP FR+ TP +RL+ + ++ LD + L +PGALPL A+GMIENV+G+F+LPL Sbjct: 4 NSTLPNFRSLTPHERLSHLRKMLDLDDTQWTQLARPGALPLERANGMIENVIGTFELPLA 63 Query: 72 VAGYFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRACGGFQTSSSLPLMRAQIQLTGISD 131 VAGYFQ+NG+DV+VPMAVEEPS+VAAASFMAKL R GGF+TSS+ PLMRAQ+Q+ G+SD Sbjct: 64 VAGYFQINGKDVIVPMAVEEPSIVAAASFMAKLAREGGGFRTSSTGPLMRAQVQIVGVSD 123 Query: 132 PHGARLAILKERQAIIDIANSRDQLLQQLGGGCRDIEVQVFPDTRRGAMVVTHLIVDVRD 191 P+GARLAIL + +I +ANSRDQ+L +LGGGCRDIEV VFPDT RGAM+V HLIVDVRD Sbjct: 124 PYGARLAILAHKDELIGLANSRDQVLLRLGGGCRDIEVHVFPDTPRGAMLVAHLIVDVRD 183 Query: 192 AMGANTVNTMAEAVAGHIERVTGGKVRLRILSNLADLRLARARVKVSADVLGTAQYRGEE 251 AMGANTVNTMAE+VAG IE +TGG VRLRILSNLADLRLARA V+ SA L T +Y GEE Sbjct: 184 AMGANTVNTMAESVAGRIEALTGGSVRLRILSNLADLRLARAHVRYSAATLATKEYSGEE 243 Query: 252 VINGIVDAYELAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRHGRYTS 311 VI+ ++DAY AA+DPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYA R GRYTS Sbjct: 244 VIDRVIDAYLFAAIDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYAARGGRYTS 303 Query: 312 LTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARVALKILGVQSAQALAEVAVAVGLA 371 LT WE AA+GDLVGT+E+PMPVGLVGGATKTHP ARV+L+++GV +AQ L E+AVAVGLA Sbjct: 304 LTTWEKAANGDLVGTIEMPMPVGLVGGATKTHPLARVSLQMMGVTTAQELGEIAVAVGLA 363 Query: 372 QNMAALRALATEGIQRGHMALHARNIALAAGAEASEMDWLVQQMVARHDVRVDYAKALLA 431 QNM ALRALATEGIQRGHM LHARNIALAAGA ++DWLV +M+ D R+D+A LLA Sbjct: 364 QNMGALRALATEGIQRGHMTLHARNIALAAGATGDDLDWLVNKMITSADFRMDFAIELLA 423 Query: 432 ERRR 435 R+ Sbjct: 424 GLRK 427 >ref|ZP_04942434.1| Hydroxymethylglutaryl-CoA reductase [Burkholderia cenocepacia PC184] gb|EAY65605.1| Hydroxymethylglutaryl-CoA reductase [Burkholderia cenocepacia PC184] Length = 428 Score = 628 bits (1619), Expect = e-178, Method: Compositional matrix adjust. Identities = 311/425 (73%), Positives = 357/425 (84%) Query: 12 DSRLPGFRTYTPAQRLAEVGRLAQLDQAEQALLGQPGALPLATADGMIENVVGSFQLPLG 71 DS LP FR+ TP QRL+ + R LD AE ALL +PGALPL TA+GMIENV+G+F+LP+ Sbjct: 4 DSALPNFRSLTPEQRLSYLSRAVGLDDAEHALLARPGALPLDTANGMIENVIGTFELPMA 63 Query: 72 VAGYFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRACGGFQTSSSLPLMRAQIQLTGISD 131 VAGYF++N RDV+VPMAVEEPS+VAAAS+MAKL RA GGF+TSSS PLMRAQ+Q+ G+ D Sbjct: 64 VAGYFRINDRDVIVPMAVEEPSIVAAASYMAKLSRAAGGFRTSSSGPLMRAQVQVVGVDD 123 Query: 132 PHGARLAILKERQAIIDIANSRDQLLQQLGGGCRDIEVQVFPDTRRGAMVVTHLIVDVRD 191 P+GARLAIL+ +I +ANSRD++L LGGGCRDIEV VFPDT RGAM+V HLIVDVRD Sbjct: 124 PYGARLAILRHAAELIALANSRDKVLVGLGGGCRDIEVHVFPDTPRGAMIVAHLIVDVRD 183 Query: 192 AMGANTVNTMAEAVAGHIERVTGGKVRLRILSNLADLRLARARVKVSADVLGTAQYRGEE 251 AMGANTVNTMAE VA IE +TGG+VRLRILSNLADLRLARA V+ SA L T Y GE Sbjct: 184 AMGANTVNTMAETVATRIEAITGGQVRLRILSNLADLRLARAEVRYSAATLATDDYAGEA 243 Query: 252 VINGIVDAYELAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRHGRYTS 311 VI+ ++DAY AA DPYRAATHNKGIMNGIDPV+VATGNDWRAVEAGAHAYA R GRYTS Sbjct: 244 VIDRVIDAYVFAATDPYRAATHNKGIMNGIDPVVVATGNDWRAVEAGAHAYASRSGRYTS 303 Query: 312 LTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARVALKILGVQSAQALAEVAVAVGLA 371 LT WE AA+GDLVGT+E+PMPVGLVGGATKTHP AR+ALKI+ V SAQAL E+AVAVGLA Sbjct: 304 LTTWEKAANGDLVGTIEMPMPVGLVGGATKTHPLARLALKIMNVTSAQALGEIAVAVGLA 363 Query: 372 QNMAALRALATEGIQRGHMALHARNIALAAGAEASEMDWLVQQMVARHDVRVDYAKALLA 431 QN+ ALRALATEGIQRGHMALHARNIA+AAGA +++D + Q+MVA DVR D+A LLA Sbjct: 364 QNLGALRALATEGIQRGHMALHARNIAVAAGATGADIDRIAQRMVAAKDVRTDFAVELLA 423 Query: 432 ERRRG 436 R G Sbjct: 424 GRSGG 428 >ref|YP_837137.1| hydroxymethylglutaryl-CoA reductase, degradative [Burkholderia cenocepacia HI2424] gb|ABK10244.1| hydroxymethylglutaryl-CoA reductase, degradative [Burkholderia cenocepacia HI2424] Length = 428 Score = 627 bits (1616), Expect = e-177, Method: Compositional matrix adjust. Identities = 311/425 (73%), Positives = 356/425 (83%) Query: 12 DSRLPGFRTYTPAQRLAEVGRLAQLDQAEQALLGQPGALPLATADGMIENVVGSFQLPLG 71 DS LP FR+ TP QRL+ + R LD AE ALL QPGALPL TA+GMIENV+G+F+LP+ Sbjct: 4 DSALPNFRSLTPEQRLSHLSRAVGLDDAEHALLAQPGALPLDTANGMIENVIGTFELPMA 63 Query: 72 VAGYFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRACGGFQTSSSLPLMRAQIQLTGISD 131 VAGYF++N RDV+VPMAVEEPS+VAAAS+MAKL RA GGF+TSSS PLMRAQ+Q+ G+ D Sbjct: 64 VAGYFRINDRDVIVPMAVEEPSIVAAASYMAKLSRAAGGFRTSSSGPLMRAQVQVIGVDD 123 Query: 132 PHGARLAILKERQAIIDIANSRDQLLQQLGGGCRDIEVQVFPDTRRGAMVVTHLIVDVRD 191 P+GARLAIL+ +I +ANSRD++L LGGGCRDIEV VFPDT RGAM+V HLIVDVRD Sbjct: 124 PYGARLAILRHAAELIALANSRDKVLVGLGGGCRDIEVHVFPDTPRGAMIVAHLIVDVRD 183 Query: 192 AMGANTVNTMAEAVAGHIERVTGGKVRLRILSNLADLRLARARVKVSADVLGTAQYRGEE 251 AMGANTVNTMAE VA IE +TGG+VRLRILSNLADLRLARA V+ SA L T Y GE Sbjct: 184 AMGANTVNTMAETVATRIEAITGGQVRLRILSNLADLRLARAEVRYSAATLATDDYAGEA 243 Query: 252 VINGIVDAYELAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRHGRYTS 311 VI+ ++DAY AA DPYRAATHNKGIMNGIDPV+VATGNDWRAVEAGAHAYA R GRYTS Sbjct: 244 VIDRVIDAYVFAATDPYRAATHNKGIMNGIDPVVVATGNDWRAVEAGAHAYASRSGRYTS 303 Query: 312 LTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARVALKILGVQSAQALAEVAVAVGLA 371 LT WE AA+GDLVGT+E+PMPVGLVGGATKTHP AR+ALKI+ V SAQ L E+AVAVGLA Sbjct: 304 LTTWEKAANGDLVGTIEMPMPVGLVGGATKTHPLARLALKIMNVTSAQELGEIAVAVGLA 363 Query: 372 QNMAALRALATEGIQRGHMALHARNIALAAGAEASEMDWLVQQMVARHDVRVDYAKALLA 431 QN+ ALRALATEGIQRGHMALHARNIA+AAGA +++D + Q+MVA DVR D+A LLA Sbjct: 364 QNLGALRALATEGIQRGHMALHARNIAVAAGATGADIDRIAQRMVAAKDVRADFAVELLA 423 Query: 432 ERRRG 436 R G Sbjct: 424 GRSGG 428 >ref|YP_002233154.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Burkholderia cenocepacia J2315] emb|CAR54389.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Burkholderia cenocepacia J2315] Length = 428 Score = 625 bits (1613), Expect = e-177, Method: Compositional matrix adjust. Identities = 309/425 (72%), Positives = 356/425 (83%) Query: 12 DSRLPGFRTYTPAQRLAEVGRLAQLDQAEQALLGQPGALPLATADGMIENVVGSFQLPLG 71 DS LP FR+ TP QRL+ + R+ LD AE ALL +PGALPL TA+GMIENV+G+F+LP+ Sbjct: 4 DSALPNFRSLTPEQRLSHLARVVGLDDAEHALLARPGALPLDTANGMIENVIGTFELPMA 63 Query: 72 VAGYFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRACGGFQTSSSLPLMRAQIQLTGISD 131 V GYF++N RDV+VPMAVEEPS+VAAAS+MAKL RA GGF+TSSS PLMRAQ+Q+ G+ D Sbjct: 64 VTGYFRINDRDVIVPMAVEEPSIVAAASYMAKLSRAAGGFRTSSSGPLMRAQVQVVGVDD 123 Query: 132 PHGARLAILKERQAIIDIANSRDQLLQQLGGGCRDIEVQVFPDTRRGAMVVTHLIVDVRD 191 P+GARLAIL+ +I +ANSRD++L LGGGCRDIEV VFPDT RGAM+V HLIVDVRD Sbjct: 124 PYGARLAILRHAAELIALANSRDKVLVGLGGGCRDIEVHVFPDTPRGAMIVAHLIVDVRD 183 Query: 192 AMGANTVNTMAEAVAGHIERVTGGKVRLRILSNLADLRLARARVKVSADVLGTAQYRGEE 251 AMGANTVNTMAE VA IE +TGG+VRLRILSNLADLRLARA V+ SA L T Y GE Sbjct: 184 AMGANTVNTMAETVATRIEAITGGQVRLRILSNLADLRLARAEVRYSAATLATDDYAGEA 243 Query: 252 VINGIVDAYELAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRHGRYTS 311 VI+ ++DAY AA DPYRAATHNKGIMNGIDPV+VATGNDWRAVEAGAHAYA R GRYTS Sbjct: 244 VIDRVIDAYVFAATDPYRAATHNKGIMNGIDPVVVATGNDWRAVEAGAHAYASRSGRYTS 303 Query: 312 LTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARVALKILGVQSAQALAEVAVAVGLA 371 LT WE AA+GDLVGT+E+PMPVGLVGGATKTHP AR+ALKI+ V SAQ L E+AVAVGLA Sbjct: 304 LTTWEKAANGDLVGTIEMPMPVGLVGGATKTHPLARLALKIMNVTSAQELGEIAVAVGLA 363 Query: 372 QNMAALRALATEGIQRGHMALHARNIALAAGAEASEMDWLVQQMVARHDVRVDYAKALLA 431 QN+ ALRALATEGIQRGHMALHARNIA+AAGA +++D + Q+MVA DVR D+A LLA Sbjct: 364 QNLGALRALATEGIQRGHMALHARNIAVAAGATGADIDRIAQRMVAAKDVRTDFAVELLA 423 Query: 432 ERRRG 436 R G Sbjct: 424 GRSDG 428 >ref|YP_004152417.1| hydroxymethylglutaryL-CoA reductase, degradative [Variovorax paradoxus EPS] gb|ADU34306.1| hydroxymethylglutaryl-CoA reductase, degradative [Variovorax paradoxus EPS] Length = 428 Score = 620 bits (1599), Expect = e-175, Method: Compositional matrix adjust. Identities = 307/424 (72%), Positives = 352/424 (83%) Query: 12 DSRLPGFRTYTPAQRLAEVGRLAQLDQAEQALLGQPGALPLATADGMIENVVGSFQLPLG 71 DSR+P FR TPAQR A + + A L E ALL QPGAL + A+GM+ENV+G+F+LPLG Sbjct: 4 DSRIPNFRALTPAQRFAHIAKAASLTDDEVALLAQPGALSVDRANGMVENVIGTFELPLG 63 Query: 72 VAGYFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRACGGFQTSSSLPLMRAQIQLTGISD 131 VAG F +NGRD LVPMAVEEPSVVAAASFMAKL R GGF+ SS+ PLMRAQ+Q+ GI+D Sbjct: 64 VAGNFTVNGRDYLVPMAVEEPSVVAAASFMAKLAREGGGFEASSTGPLMRAQVQVIGITD 123 Query: 132 PHGARLAILKERQAIIDIANSRDQLLQQLGGGCRDIEVQVFPDTRRGAMVVTHLIVDVRD 191 P+GARLA+L+ R+ I+ +ANSRD++L LGGGCRDIEV VF DT RGAMVV HLIVDVRD Sbjct: 124 PYGARLALLRAREEILAVANSRDKVLIDLGGGCRDIEVHVFGDTPRGAMVVMHLIVDVRD 183 Query: 192 AMGANTVNTMAEAVAGHIERVTGGKVRLRILSNLADLRLARARVKVSADVLGTAQYRGEE 251 AMGANTVNTMAEAV+ +E++TGG VRLRILSNLADLRLARARV+++ VL T + GEE Sbjct: 184 AMGANTVNTMAEAVSPLVEKLTGGTVRLRILSNLADLRLARARVRLAPAVLATRERSGEE 243 Query: 252 VINGIVDAYELAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRHGRYTS 311 V+ G++DAY AA+DPYRAATHNKGIMNG+DPVIVATGNDWRAVEAGAHAYACR GRYTS Sbjct: 244 VVEGVIDAYTFAAIDPYRAATHNKGIMNGVDPVIVATGNDWRAVEAGAHAYACRSGRYTS 303 Query: 312 LTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARVALKILGVQSAQALAEVAVAVGLA 371 LT WE G LVGT+E+PMPVGLVGGATKTHP AR+ALKIL V+SAQ L EVAVAVGLA Sbjct: 304 LTTWEKDTTGALVGTIEMPMPVGLVGGATKTHPLARLALKILDVKSAQELGEVAVAVGLA 363 Query: 372 QNMAALRALATEGIQRGHMALHARNIALAAGAEASEMDWLVQQMVARHDVRVDYAKALLA 431 QN+ ALRALATEGIQRGHMALHARNIAL AGA E+D + +QM A HDVR D A ALL Sbjct: 364 QNLGALRALATEGIQRGHMALHARNIALVAGATGDEIDSIAKQMAAEHDVRTDRAVALLE 423 Query: 432 ERRR 435 R+ Sbjct: 424 ALRK 427 >ref|YP_004348406.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Burkholderia gladioli BSR3] gb|AEA62894.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Burkholderia gladioli BSR3] Length = 427 Score = 619 bits (1597), Expect = e-175, Method: Compositional matrix adjust. Identities = 315/423 (74%), Positives = 358/423 (84%) Query: 12 DSRLPGFRTYTPAQRLAEVGRLAQLDQAEQALLGQPGALPLATADGMIENVVGSFQLPLG 71 DS LP FR+ TPA+RLA + A LD A+ ALL +PGALP+ A+GMIENV+G+F+LPL Sbjct: 4 DSALPDFRSLTPAERLARIAAAAGLDDAQHALLAKPGALPIEVANGMIENVIGTFELPLA 63 Query: 72 VAGYFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRACGGFQTSSSLPLMRAQIQLTGISD 131 VAGYF++NG DVLVPMAVEEPS+VAAASFMAKL R GGF+TSS+ PLMRAQ+Q+ GI D Sbjct: 64 VAGYFRINGEDVLVPMAVEEPSIVAAASFMAKLAREAGGFRTSSTGPLMRAQVQVLGIDD 123 Query: 132 PHGARLAILKERQAIIDIANSRDQLLQQLGGGCRDIEVQVFPDTRRGAMVVTHLIVDVRD 191 P+GAR IL R +I++AN+RD +L +LGGGCRDIEVQVFPDT RGAMVV HLIVDVRD Sbjct: 124 PYGARQTILAARDELIELANARDAVLVKLGGGCRDIEVQVFPDTPRGAMVVAHLIVDVRD 183 Query: 192 AMGANTVNTMAEAVAGHIERVTGGKVRLRILSNLADLRLARARVKVSADVLGTAQYRGEE 251 AMGANTVNTMAEAVAG IE +TGG VRLRILSNLADLRLARA V+ SA L T +Y GE Sbjct: 184 AMGANTVNTMAEAVAGRIEALTGGTVRLRILSNLADLRLARAHVRYSAATLATREYSGEA 243 Query: 252 VINGIVDAYELAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRHGRYTS 311 VI+G++DAY LAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYA R GRYTS Sbjct: 244 VIDGVIDAYLLAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYASRGGRYTS 303 Query: 312 LTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARVALKILGVQSAQALAEVAVAVGLA 371 LT WE AA+GDLVGT+E+PMPVGLVGGAT+THP AR AL+ILGVQSAQ L E+A AVGLA Sbjct: 304 LTTWEKAANGDLVGTIELPMPVGLVGGATRTHPLARAALRILGVQSAQRLGEIAAAVGLA 363 Query: 372 QNMAALRALATEGIQRGHMALHARNIALAAGAEASEMDWLVQQMVARHDVRVDYAKALLA 431 QNM ALRALATEGIQRGHMALHARNIA+AAGA +++DW+ ++M A DVR D A LLA Sbjct: 364 QNMGALRALATEGIQRGHMALHARNIAIAAGASGADIDWVARKMAAARDVRTDRALELLA 423 Query: 432 ERR 434 R Sbjct: 424 GPR 426 >ref|ZP_08275680.1| Hydroxymethylglutaryl-CoA reductase [Oxalobacteraceae bacterium IMCC9480] gb|EGF30846.1| Hydroxymethylglutaryl-CoA reductase [Oxalobacteraceae bacterium IMCC9480] Length = 426 Score = 618 bits (1594), Expect = e-175, Method: Compositional matrix adjust. Identities = 299/423 (70%), Positives = 356/423 (84%) Query: 10 TPDSRLPGFRTYTPAQRLAEVGRLAQLDQAEQALLGQPGALPLATADGMIENVVGSFQLP 69 T DSRLP FR PA RL + +A L E+AL+ +PG+LPL A+GM+ENV+G F+LP Sbjct: 2 TIDSRLPNFRALDPAARLDHIVAVAGLTPEERALIAEPGSLPLEVANGMVENVIGKFELP 61 Query: 70 LGVAGYFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRACGGFQTSSSLPLMRAQIQLTGI 129 VAGYFQ+NGRDVLVPM VEEPSVVAAASFMAK++R GGFQTSS+ PLMRAQ+Q+ + Sbjct: 62 YSVAGYFQINGRDVLVPMVVEEPSVVAAASFMAKIIRESGGFQTSSTGPLMRAQVQVMEL 121 Query: 130 SDPHGARLAILKERQAIIDIANSRDQLLQQLGGGCRDIEVQVFPDTRRGAMVVTHLIVDV 189 +DP GAR A+L +Q +I +ANSRD++L LGGGC+DIEV VF DT RG MV+ HLIVDV Sbjct: 122 ADPFGARHAVLSHKQELITLANSRDKVLIGLGGGCKDIEVHVFADTARGPMVIVHLIVDV 181 Query: 190 RDAMGANTVNTMAEAVAGHIERVTGGKVRLRILSNLADLRLARARVKVSADVLGTAQYRG 249 RDAMGANTVNTMAEAVAG IE +TGGKVRLRILSNLADLRLARARV++ ++L +A Y Sbjct: 182 RDAMGANTVNTMAEAVAGRIEAITGGKVRLRILSNLADLRLARARVQIRPELLKSADYTA 241 Query: 250 EEVINGIVDAYELAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRHGRY 309 ++VINGI+DAY AA+DPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACR GRY Sbjct: 242 DQVINGIIDAYTFAAIDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRDGRY 301 Query: 310 TSLTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARVALKILGVQSAQALAEVAVAVG 369 TSLT WE++A GDLVGT+E+PMPVGLVGGATKTHP AR++LKI+ ++SAQ LAE+AVAVG Sbjct: 302 TSLTTWEVSATGDLVGTIEMPMPVGLVGGATKTHPMARLSLKIMQLRSAQELAEIAVAVG 361 Query: 370 LAQNMAALRALATEGIQRGHMALHARNIALAAGAEASEMDWLVQQMVARHDVRVDYAKAL 429 LAQN+ ALRAL+TEGIQRGHMALHARNIA+ AGA +++D + ++MVA DVR D+A L Sbjct: 362 LAQNLGALRALSTEGIQRGHMALHARNIAIVAGATGADVDRIAREMVAAGDVRADFAAEL 421 Query: 430 LAE 432 L + Sbjct: 422 LGK 424