BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0031.0213.p (345 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|ZP_08826101.1| N-acetylneuraminate synthase [Neisseria weave... 494 e-138 gb|ABW08128.1| Neu-NAC synthetase [Neisseria meningitidis] 492 e-137 gb|ABW08139.1| Neu-NAC synthetase [Neisseria meningitidis] >gi|1... 491 e-137 ref|NP_273132.1| polysialic acid capsule biosynthesis protein Si... 491 e-137 gb|ADZ00629.1| polysialic acid capsule biosynthesis protein SiaC... 488 e-136 gb|ADY96709.1| polysialic acid capsule biosynthesis protein SiaC... 487 e-135 pdb|2WQP|A Chain A, Crystal Structure Of Sialic Acid Synthase Ne... 469 e-130 gb|EGS72861.1| polysialic acid capsule biosynthesis protein SiaC... 469 e-130 ref|YP_003840214.1| N-acetylneuraminate synthase [Caldicellulosi... 456 e-126 ref|YP_154911.1| sialic acid synthase [Idiomarina loihiensis L2T... 456 e-126 >ref|ZP_08826101.1| N-acetylneuraminate synthase [Neisseria weaveri LMG 5135] gb|EGV36093.1| N-acetylneuraminate synthase [Neisseria weaveri ATCC 51223] gb|EGV38733.1| N-acetylneuraminate synthase [Neisseria weaveri LMG 5135] Length = 350 Score = 494 bits (1272), Expect = e-138, Method: Compositional matrix adjust. Identities = 241/343 (70%), Positives = 276/343 (80%), Gaps = 1/343 (0%) Query: 3 EFSIAGRMVGDDHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEMSD 62 EF I R VG H PL+I EIGINHEGSL A MVDAA AGAE+IKHQTHVVEDEMSD Sbjct: 6 EFKIGHRSVGAMHEPLIICEIGINHEGSLQTAFEMVDAAHRAGAEIIKHQTHVVEDEMSD 65 Query: 63 EAKSVIPGNADVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDI 122 EAK VIPGNADVSIYEIMERCALSE DE KL +YV+S+G IFISTPFSRAAA RL + DI Sbjct: 66 EAKQVIPGNADVSIYEIMERCALSEEDEIKLKEYVESKGMIFISTPFSRAAALRLQKMDI 125 Query: 123 AAFKIGSGECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVPFALLHCTNV 182 A+KIGSGECNNYPLIK +A +GKP+I+STGMNT+ES+R +V+I+R+AGVP+ALLHCTN+ Sbjct: 126 PAYKIGSGECNNYPLIKLIASFGKPIILSTGMNTVESIRKSVDIIREAGVPYALLHCTNI 185 Query: 183 YPTPPELVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPG 242 YPTP E VRLGAM EL QA+PDAVVGLSDHT+ N+ CLGAVALGASILERHFTD M+RPG Sbjct: 186 YPTPYEDVRLGAMTELAQAFPDAVVGLSDHTLDNYACLGAVALGASILERHFTDHMNRPG 245 Query: 243 PDILCSMDPSALSDLVHGSATIFKARGAGKGPVEA-EAPTIAFAFASVVAYKAIGEGETL 301 PDI+CSMDP A +L G+ + KARG K V A E PT FAFASVVA K I +GE Sbjct: 246 PDIVCSMDPQAFQELKQGAGILKKARGGRKDTVIAGEKPTKDFAFASVVADKEIRQGEVF 305 Query: 302 TEDNLWLRRPGTGDFGPTDYEPLLGRVAARSIKAGAQIRKDDL 344 T +NLW++RPGTGDF DYE L G+ AAR I G Q++K D+ Sbjct: 306 TAENLWVKRPGTGDFNAGDYEVLFGKTAARDIPKGTQLKKADV 348 >gb|ABW08128.1| Neu-NAC synthetase [Neisseria meningitidis] Length = 352 Score = 492 bits (1267), Expect = e-137, Method: Compositional matrix adjust. Identities = 234/344 (68%), Positives = 279/344 (81%), Gaps = 1/344 (0%) Query: 3 EFSIAGRMVGDDHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEMSD 62 EF I R VG +H PL+I EIGINHEGSL A MVDAA +AGAEV+KHQTH+VEDEMSD Sbjct: 6 EFKIGNRSVGYNHEPLIICEIGINHEGSLKTAFEMVDAAYNAGAEVVKHQTHIVEDEMSD 65 Query: 63 EAKSVIPGNADVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDI 122 EAK VIPGNADVSIYEIMERCAL+E DE KL +YV+S+G IFISTPFSRAAA RL R DI Sbjct: 66 EAKQVIPGNADVSIYEIMERCALNEEDEIKLKEYVESKGMIFISTPFSRAAALRLQRMDI 125 Query: 123 AAFKIGSGECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVPFALLHCTNV 182 A+KIGSGECNNYPLIK VA +GKP+I+STGMN++ES++ +VEI+R+AGVP+ALLHCTN+ Sbjct: 126 PAYKIGSGECNNYPLIKLVASFGKPIILSTGMNSIESIKKSVEIIREAGVPYALLHCTNI 185 Query: 183 YPTPPELVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPG 242 YPTP E VRLG M +L +A+PDA++GLSDHT+ N+ CLGAVALG SILERHFTDRMDRPG Sbjct: 186 YPTPYEDVRLGGMNDLSEAFPDAIIGLSDHTLDNYACLGAVALGGSILERHFTDRMDRPG 245 Query: 243 PDILCSMDPSALSDLVHGSATIFKARGAGKGPVEA-EAPTIAFAFASVVAYKAIGEGETL 301 PDI+CSM+P +L G+ + ARG K + A E PT FAFASVVA K I +GE L Sbjct: 246 PDIVCSMNPDTFKELKQGAHALKLARGGKKDTIIAGEKPTKDFAFASVVADKDIKKGELL 305 Query: 302 TEDNLWLRRPGTGDFGPTDYEPLLGRVAARSIKAGAQIRKDDLR 345 + DNLW++RPG GDF +YE L G+VAA +I+ GAQI+K D+R Sbjct: 306 SGDNLWVKRPGNGDFSVNEYETLFGKVAACNIRKGAQIKKTDIR 349 >gb|ABW08139.1| Neu-NAC synthetase [Neisseria meningitidis] gb|ABW93673.1| SiaC [Neisseria meningitidis] gb|ABW93689.1| SiaC [Neisseria meningitidis] emb|CBA09684.1| N-acetylneuraminic acid synthetase [Neisseria meningitidis alpha275] Length = 349 Score = 491 bits (1265), Expect = e-137, Method: Compositional matrix adjust. Identities = 233/343 (67%), Positives = 278/343 (81%), Gaps = 1/343 (0%) Query: 3 EFSIAGRMVGDDHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEMSD 62 EF I R VG +H PL+I EIGINHEGSL A MVDAA +AGAEV+KHQTH+VEDEMSD Sbjct: 6 EFKIGNRSVGYNHEPLIICEIGINHEGSLKTAFEMVDAAYNAGAEVVKHQTHIVEDEMSD 65 Query: 63 EAKSVIPGNADVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDI 122 EAK VIPGNADVSIYEIMERCAL+E DE KL +YV+S+G IFISTPFSRAAA RL R DI Sbjct: 66 EAKQVIPGNADVSIYEIMERCALNEEDEIKLKEYVESKGMIFISTPFSRAAALRLQRMDI 125 Query: 123 AAFKIGSGECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVPFALLHCTNV 182 A+KIGSGECNNYPLIK VA +GKP+I+STGMN++ES++ +VEI+R+AGVP+ALLHCTN+ Sbjct: 126 PAYKIGSGECNNYPLIKLVASFGKPIILSTGMNSIESIKKSVEIIREAGVPYALLHCTNI 185 Query: 183 YPTPPELVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPG 242 YPTP E VRLG M +L +A+PDA++GLSDHT+ N+ CLGAVALG SILERHFTDRMDRPG Sbjct: 186 YPTPYEDVRLGGMNDLSEAFPDAIIGLSDHTLDNYACLGAVALGGSILERHFTDRMDRPG 245 Query: 243 PDILCSMDPSALSDLVHGSATIFKARGAGKGPVEA-EAPTIAFAFASVVAYKAIGEGETL 301 PDI+CSM+P +L G+ + ARG K + A E PT FAFASVVA K I +GE L Sbjct: 246 PDIVCSMNPDTFKELKQGAHALKLARGGKKDTIIAGEKPTKDFAFASVVADKDIKKGELL 305 Query: 302 TEDNLWLRRPGTGDFGPTDYEPLLGRVAARSIKAGAQIRKDDL 344 + DNLW++RPG GDF +YE L G+VAA +I+ GAQI+K D+ Sbjct: 306 SGDNLWVKRPGNGDFSVNEYETLFGKVAACNIRKGAQIKKTDI 348 >ref|NP_273132.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis MC58] ref|YP_974194.1| N-acetylneuraminic acid synthetase [Neisseria meningitidis FAM18] ref|YP_001598253.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis 053442] ref|ZP_07370929.1| N-acetylneuraminate synthase [Neisseria meningitidis ATCC 13091] pdb|1XUU|A Chain A, Crystal Structure Of Sialic Acid Synthase (Neub) In Complex With Mn2+ And Malate From Neisseria Meningitidis pdb|1XUZ|A Chain A, Crystal Structure Analysis Of Sialic Acid Synthase (Neub) From Neisseria Meningitidis, Bound To Mn2+, Phosphoenolpyruvate, And N-Acetyl Mannosaminitol pdb|2ZDR|A Chain A, Crystal Structure Of Sialic Acid Synthase (Neub) From Neisseria Meningitidis In Complex With Mg2+ And (4s)-2- Methyl-2,4-Pentanediol pdb|3CM4|A Chain A, Crystal Structure Of Metal-Free Sialic Acid Synthase (Neub) From Neisseria Meningitidis In Complex With Malate gb|AAA20477.1| siaC [Neisseria meningitidis] emb|CAA54984.1| synC [Neisseria meningitidis serogroup B] gb|AAB17455.1| capsule biosynthesis protein [Neisseria meningitidis] gb|AAF40535.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis MC58] emb|CAM09376.1| N-acetylneuraminic acid synthetase [Neisseria meningitidis FAM18] gb|ABX72300.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis 053442] emb|CAX49052.1| sialic acid synthase (N-acetylneuraminate synthase; N-acetylneuraminic acid synthase) [Neisseria meningitidis 8013] gb|ADK90955.1| SiaC [Neisseria meningitidis] gb|EFM03356.1| N-acetylneuraminate synthase [Neisseria meningitidis ATCC 13091] gb|ADO30609.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis alpha710] gb|EFV64860.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis H44/76] gb|EGC53834.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis OX99.30304] gb|EGC55813.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis M6190] gb|EGC57821.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis M13399] gb|EGC59731.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis M0579] gb|EGC61310.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis ES14902] gb|EGC63731.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis CU385] gb|EGC65633.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis 961-5945] gb|EGC65664.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis 961-5945] gb|EGC65676.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis 961-5945] gb|EGC67684.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis M01-240013] gb|EGC67730.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis M01-240013] gb|ADY92829.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis G2136] gb|ADY94749.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis H44/76] gb|ADY98647.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis M01-240355] prf||2020421C CMP-NeuNAc synthetase Length = 349 Score = 491 bits (1264), Expect = e-137, Method: Compositional matrix adjust. Identities = 233/343 (67%), Positives = 278/343 (81%), Gaps = 1/343 (0%) Query: 3 EFSIAGRMVGDDHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEMSD 62 EF I R VG +H PL+I EIGINHEGSL A MVDAA +AGAEV+KHQTH+VEDEMSD Sbjct: 6 EFKIGNRSVGYNHEPLIICEIGINHEGSLKTAFEMVDAAYNAGAEVVKHQTHIVEDEMSD 65 Query: 63 EAKSVIPGNADVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDI 122 EAK VIPGNADVSIYEIMERCAL+E DE KL +YV+S+G IFISTPFSRAAA RL R DI Sbjct: 66 EAKQVIPGNADVSIYEIMERCALNEEDEIKLKEYVESKGMIFISTPFSRAAALRLQRMDI 125 Query: 123 AAFKIGSGECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVPFALLHCTNV 182 A+KIGSGECNNYPLIK VA +GKP+I+STGMN++ES++ +VEI+R+AGVP+ALLHCTN+ Sbjct: 126 PAYKIGSGECNNYPLIKLVASFGKPIILSTGMNSIESIKKSVEIIREAGVPYALLHCTNI 185 Query: 183 YPTPPELVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPG 242 YPTP E VRLG M +L +A+PDA++GLSDHT+ N+ CLGAVALG SILERHFTDRMDRPG Sbjct: 186 YPTPYEDVRLGGMNDLSEAFPDAIIGLSDHTLDNYACLGAVALGGSILERHFTDRMDRPG 245 Query: 243 PDILCSMDPSALSDLVHGSATIFKARGAGKGPVEA-EAPTIAFAFASVVAYKAIGEGETL 301 PDI+CSM+P +L G+ + ARG K + A E PT FAFASVVA K I +GE L Sbjct: 246 PDIVCSMNPDTFKELKQGAHALKLARGGKKDTIIAGEKPTKDFAFASVVADKDIKKGELL 305 Query: 302 TEDNLWLRRPGTGDFGPTDYEPLLGRVAARSIKAGAQIRKDDL 344 + DNLW++RPG GDF +YE L G+VAA +I+ GAQI+K D+ Sbjct: 306 SGDNLWVKRPGNGDFSVNEYETLFGKVAACNIRKGAQIKKTDI 348 >gb|ADZ00629.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis M04-240196] Length = 349 Score = 488 bits (1256), Expect = e-136, Method: Compositional matrix adjust. Identities = 232/343 (67%), Positives = 277/343 (80%), Gaps = 1/343 (0%) Query: 3 EFSIAGRMVGDDHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEMSD 62 EF I R VG +H PL+I EIGINHEGSL A MVDAA +AGAEV+KHQTH+VEDEMSD Sbjct: 6 EFKIGNRSVGYNHEPLIICEIGINHEGSLKTAFEMVDAAYNAGAEVVKHQTHIVEDEMSD 65 Query: 63 EAKSVIPGNADVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDI 122 EAK VIPGNADVSIYEIMERCAL+E DE KL +YV+S+G IFISTPFSRAAA RL R DI Sbjct: 66 EAKQVIPGNADVSIYEIMERCALNEEDEIKLKEYVESKGMIFISTPFSRAAALRLQRMDI 125 Query: 123 AAFKIGSGECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVPFALLHCTNV 182 A+KIGSGECNNYPLIK VA +GKP+I+STGMN++ES++ +VEI+R+AGVP+ALLHCTN+ Sbjct: 126 PAYKIGSGECNNYPLIKLVASFGKPIILSTGMNSIESIKKSVEIIREAGVPYALLHCTNI 185 Query: 183 YPTPPELVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPG 242 YPTP E VRLG M +L +A+PDA++GLSDHT+ N+ CLGAVALG SILERHFTDRMDR G Sbjct: 186 YPTPYEDVRLGGMNDLSEAFPDAIIGLSDHTLDNYACLGAVALGGSILERHFTDRMDRLG 245 Query: 243 PDILCSMDPSALSDLVHGSATIFKARGAGKGPVEA-EAPTIAFAFASVVAYKAIGEGETL 301 PDI+CSM+P +L G+ + ARG K + A E PT FAFASVVA K I +GE L Sbjct: 246 PDIVCSMNPDTFKELKQGAHALKLARGGKKDTIIAGEKPTKDFAFASVVADKDIKKGELL 305 Query: 302 TEDNLWLRRPGTGDFGPTDYEPLLGRVAARSIKAGAQIRKDDL 344 + DNLW++RPG GDF +YE L G+VAA +I+ GAQI+K D+ Sbjct: 306 SGDNLWVKRPGNGDFSVNEYETLFGKVAACNIRKGAQIKKTDI 348 >gb|ADY96709.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis M01-240149] gb|ADZ02566.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis NZ-05/33] Length = 349 Score = 487 bits (1253), Expect = e-135, Method: Compositional matrix adjust. Identities = 231/343 (67%), Positives = 276/343 (80%), Gaps = 1/343 (0%) Query: 3 EFSIAGRMVGDDHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEMSD 62 EF I R VG +H PL+I EIGINHEGSL A MVDAA +AGAEV+KHQTH+VEDEMSD Sbjct: 6 EFKIGNRSVGYNHEPLIICEIGINHEGSLKTAFEMVDAAYNAGAEVVKHQTHIVEDEMSD 65 Query: 63 EAKSVIPGNADVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDI 122 EAK VIPGNADVSIYEIMERCAL+E DE KL +YV+S+G IFISTPFSRAAA RL R DI Sbjct: 66 EAKQVIPGNADVSIYEIMERCALNEEDEIKLKEYVESKGMIFISTPFSRAAALRLQRMDI 125 Query: 123 AAFKIGSGECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVPFALLHCTNV 182 A+KIGSGECNNYPLIK VA +GKP+I+STGMN++ES++ +VEI+R+AGVP+ALLHCTN+ Sbjct: 126 PAYKIGSGECNNYPLIKLVASFGKPIILSTGMNSIESIKKSVEIIREAGVPYALLHCTNI 185 Query: 183 YPTPPELVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPG 242 YPTP E VRLG M +L +A+ DA++GLSDHT+ N+ CLGAVALG SILERHFTDRMDRPG Sbjct: 186 YPTPYEDVRLGGMNDLSEAFLDAIIGLSDHTLDNYACLGAVALGGSILERHFTDRMDRPG 245 Query: 243 PDILCSMDPSALSDLVHGSATIFKARGAGKGPVEA-EAPTIAFAFASVVAYKAIGEGETL 301 PDI+CSM+P +L G+ + ARG K + A E PT FAFASVVA K I +GE L Sbjct: 246 PDIVCSMNPDTFKELKQGAHALKLARGGKKDTIIAGEKPTKDFAFASVVADKDIKKGELL 305 Query: 302 TEDNLWLRRPGTGDFGPTDYEPLLGRVAARSIKAGAQIRKDDL 344 + DNLW++RPG GDF +YE L G++AA I+ GAQI+K D+ Sbjct: 306 SGDNLWVKRPGNGDFSVNEYESLFGKIAACDIRKGAQIKKTDI 348 >pdb|2WQP|A Chain A, Crystal Structure Of Sialic Acid Synthase Neub-Inhibitor Complex Length = 349 Score = 469 bits (1206), Expect = e-130, Method: Compositional matrix adjust. Identities = 225/343 (65%), Positives = 270/343 (78%), Gaps = 1/343 (0%) Query: 3 EFSIAGRMVGDDHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEMSD 62 EF I R VG +H PL+I EIGINHEGSL A VDAA +AGAEV+KHQTH+VEDE SD Sbjct: 6 EFKIGNRSVGYNHEPLIICEIGINHEGSLKTAFEXVDAAYNAGAEVVKHQTHIVEDEXSD 65 Query: 63 EAKSVIPGNADVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDI 122 EAK VIPGNADVSIYEI ERCAL+E DE KL +YV+S+G IFIST FSRAAA RL R DI Sbjct: 66 EAKQVIPGNADVSIYEIXERCALNEEDEIKLKEYVESKGXIFISTLFSRAAALRLQRXDI 125 Query: 123 AAFKIGSGECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVPFALLHCTNV 182 A+KIGSGECNNYPLIK VA +GKP+I+STG N++ES++ +VEI+R+AGVP+ALLHCTN+ Sbjct: 126 PAYKIGSGECNNYPLIKLVASFGKPIILSTGXNSIESIKKSVEIIREAGVPYALLHCTNI 185 Query: 183 YPTPPELVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPG 242 YPTP E VRLG +L +A+PDA++GLSDHT+ N+ CLGAVALG SILERHFTDR DRPG Sbjct: 186 YPTPYEDVRLGGXNDLSEAFPDAIIGLSDHTLDNYACLGAVALGGSILERHFTDRXDRPG 245 Query: 243 PDILCSMDPSALSDLVHGSATIFKARGAGKGPVEA-EAPTIAFAFASVVAYKAIGEGETL 301 PDI+CS +P +L G+ + ARG K + A E PT FAFASVVA K I +GE L Sbjct: 246 PDIVCSXNPDTFKELKQGAHALKLARGGKKDTIIAGEKPTKDFAFASVVADKDIKKGELL 305 Query: 302 TEDNLWLRRPGTGDFGPTDYEPLLGRVAARSIKAGAQIRKDDL 344 + DNLW++RPG GDF +YE L G+VAA +I+ GAQI+K D+ Sbjct: 306 SGDNLWVKRPGNGDFSVNEYETLFGKVAACNIRKGAQIKKTDI 348 >gb|EGS72861.1| polysialic acid capsule biosynthesis protein SiaC [Vibrio cholerae BJG-01] Length = 347 Score = 469 bits (1206), Expect = e-130, Method: Compositional matrix adjust. Identities = 221/342 (64%), Positives = 271/342 (79%) Query: 4 FSIAGRMVGDDHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEMSDE 63 F I+GR +G D+ PLVIAEIGINHEGSL VA MVDAAI+ GAEVIKHQTH+VEDEMS E Sbjct: 6 FEISGRKIGLDYDPLVIAEIGINHEGSLKVAYEMVDAAIEGGAEVIKHQTHIVEDEMSGE 65 Query: 64 AKSVIPGNADVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDIA 123 AKSVIPGNADVSIYEIMERCAL+E DE KL +YV+S+GAIFISTPFSRAAAERL R ++ Sbjct: 66 AKSVIPGNADVSIYEIMERCALNEEDEIKLKEYVESKGAIFISTPFSRAAAERLERMNVP 125 Query: 124 AFKIGSGECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVPFALLHCTNVY 183 A+KIGSGECNNYPL+ +A YGKP+I+STGMN + S++ V+I RK PF LLH TN+Y Sbjct: 126 AYKIGSGECNNYPLLDLIASYGKPIILSTGMNDISSIQKAVDIFRKHKTPFCLLHTTNLY 185 Query: 184 PTPPELVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPGP 243 PTP L+R+GAM++L+ A+PDAVVGLSDH++ N CLGAVA GAS+LERHFTDR DRPGP Sbjct: 186 PTPDHLIRIGAMEQLQDAFPDAVVGLSDHSIDNLACLGAVAAGASVLERHFTDRKDRPGP 245 Query: 244 DILCSMDPSALSDLVHGSATIFKARGAGKGPVEAEAPTIAFAFASVVAYKAIGEGETLTE 303 DI+CSMD ++L+ S + + RG K + E TI FA+ASVV I EGE+ T Sbjct: 246 DIVCSMDAKECAELIAQSKRMARMRGGKKEAAKEEQVTIDFAYASVVTIAEIKEGESFTR 305 Query: 304 DNLWLRRPGTGDFGPTDYEPLLGRVAARSIKAGAQIRKDDLR 345 DNLW++RPGTGDF DYE L+G+VA ++I A Q++K+ ++ Sbjct: 306 DNLWVKRPGTGDFLAKDYESLIGKVALQAIPADVQLKKEYVK 347 >ref|YP_003840214.1| N-acetylneuraminate synthase [Caldicellulosiruptor obsidiansis OB47] gb|ADL42228.1| N-acetylneuraminate synthase [Caldicellulosiruptor obsidiansis OB47] Length = 348 Score = 456 bits (1174), Expect = e-126, Method: Compositional matrix adjust. Identities = 214/341 (62%), Positives = 265/341 (77%) Query: 4 FSIAGRMVGDDHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEMSDE 63 I R +G+D+ PLVIAEIGINH GSL VA MVDAA +AGAEVIKHQTH+VEDEMS E Sbjct: 6 IQIGNRKIGEDYPPLVIAEIGINHGGSLEVAKKMVDAAYEAGAEVIKHQTHIVEDEMSKE 65 Query: 64 AKSVIPGNADVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDIA 123 AK VIPGNA+VSIYEI++RCALSE +E +L YV+S+G IF+STPFS+AA +RL + D+ Sbjct: 66 AKKVIPGNANVSIYEIIKRCALSEEEEYELKRYVESKGMIFLSTPFSKAAVDRLVKMDVL 125 Query: 124 AFKIGSGECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVPFALLHCTNVY 183 AFK+GSGECNNYPLI+++A +GKPMIVSTGMN ++SV+ TVEI+ K + +ALLHCTN+Y Sbjct: 126 AFKVGSGECNNYPLIEYIASFGKPMIVSTGMNDIKSVKKTVEILEKYNIQYALLHCTNLY 185 Query: 184 PTPPELVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPGP 243 PTPP LVRLG + ELK+ +P+AV+GLSDHTV+N+ CL AVALGASILERHFTD DRPGP Sbjct: 186 PTPPHLVRLGGLLELKETFPNAVIGLSDHTVNNYACLAAVALGASILERHFTDSKDRPGP 245 Query: 244 DILCSMDPSALSDLVHGSATIFKARGAGKGPVEAEAPTIAFAFASVVAYKAIGEGETLTE 303 DI+CSMDP L +L+ SA I RG K PV E T+ FAFA+VVA K I G+ LT+ Sbjct: 246 DIVCSMDPKELKELIEASAQIALMRGGKKEPVPEEKVTMDFAFATVVAIKNIKAGDVLTK 305 Query: 304 DNLWLRRPGTGDFGPTDYEPLLGRVAARSIKAGAQIRKDDL 344 DN+W++RPG G+ Y LLG+ A R I +R +D+ Sbjct: 306 DNIWVKRPGIGEIKAEYYYDLLGKRAKRDILEDEHLRWEDI 346 >ref|YP_154911.1| sialic acid synthase [Idiomarina loihiensis L2TR] gb|AAV81362.1| Sialic acid synthase [Idiomarina loihiensis L2TR] Length = 352 Score = 456 bits (1172), Expect = e-126, Method: Compositional matrix adjust. Identities = 217/342 (63%), Positives = 260/342 (76%) Query: 4 FSIAGRMVGDDHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEMSDE 63 I R +G DH P+V+AEIGINHEGSL A MVDAA+ AGAE+IKHQTHVVEDEMS + Sbjct: 11 MKIGSREIGYDHDPVVVAEIGINHEGSLETAYEMVDAAVSAGAEIIKHQTHVVEDEMSAD 70 Query: 64 AKSVIPGNADVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDIA 123 AK VIPGNADVSIYEIMERCAL+E DE KL +YV+S+GAIFISTPFSRAAAERL R + Sbjct: 71 AKKVIPGNADVSIYEIMERCALNEEDETKLKEYVESKGAIFISTPFSRAAAERLERMGVE 130 Query: 124 AFKIGSGECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVPFALLHCTNVY 183 A+KIGSGECNNYPL++ VA Y KP+I+STGMN + S+ V+I RK GV +ALLHCTNVY Sbjct: 131 AYKIGSGECNNYPLLELVASYKKPIILSTGMNDIPSIAKAVDIFRKHGVQYALLHCTNVY 190 Query: 184 PTPPELVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPGP 243 PTP L+RLGAM +L+ A+ DAVVGLSDH++ N CLGAVA+GASILERHFTD R GP Sbjct: 191 PTPDNLIRLGAMNQLQDAFDDAVVGLSDHSIDNLACLGAVAVGASILERHFTDHKQRTGP 250 Query: 244 DILCSMDPSALSDLVHGSATIFKARGAGKGPVEAEAPTIAFAFASVVAYKAIGEGETLTE 303 DI CSMD L+ S + RG KG V E TI FA+ASVV K I +GET ++ Sbjct: 251 DINCSMDTEECRSLIQESKRMKAMRGGQKGAVAEEQVTIDFAYASVVTIKPIKKGETFSQ 310 Query: 304 DNLWLRRPGTGDFGPTDYEPLLGRVAARSIKAGAQIRKDDLR 345 DNLW++RPGTG F DYE L+G+ AA+ I+ Q+R +D++ Sbjct: 311 DNLWVKRPGTGQFLADDYENLMGKTAAQDIENDVQLRSEDVQ 352