BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0027.0150.p (683 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003775545.1| signal transduction containing PAS/GGDEF/EAL... 1400 0.0 gb|EGW61550.1| diguanylate cyclase/phosphodiesterase with PAS/PA... 511 e-142 ref|ZP_08775749.1| response regulator receiver modulated diguany... 467 e-129 ref|YP_003051624.1| PAS/PAC sensor-containing diguanylate cyclas... 465 e-128 ref|YP_004040252.1| PAS/PAC sensor-containing diguanylate cyclas... 465 e-128 ref|ZP_05072778.1| ggdef domain protein [Campylobacterales bacte... 463 e-128 gb|EGW59617.1| diguanylate cyclase/phosphodiesterase with PAS/PA... 460 e-127 ref|YP_356762.1| EAL and GGDEF domain-containing protein [Peloba... 459 e-126 gb|EGW62852.1| diguanylate cyclase/phosphodiesterase with PAS/PA... 455 e-125 ref|YP_003640479.1| diguanylate cyclase/phosphodiesterase with P... 454 e-125 >ref|YP_003775545.1| signal transduction containing PAS/GGDEF/EAL domains protein [Herbaspirillum seropedicae SmR1] gb|ADJ63637.1| signal transduction containing PAS/GGDEF/EAL domains protein [Herbaspirillum seropedicae SmR1] Length = 683 Score = 1400 bits (3623), Expect = 0.0, Method: Compositional matrix adjust. Identities = 681/682 (99%), Positives = 682/682 (100%) Query: 1 MLSSVGTDDLACCSALLEAMQNLHGMALHAALGGIASGLLKRPGGRYVIGASAPVEGGLC 60 MLSSVGTDDLACCSALLEAMQNLHGMALHAALGGIASGLLKRPGGRYVIGASAPVEGGLC Sbjct: 1 MLSSVGTDDLACCSALLEAMQNLHGMALHAALGGIASGLLKRPGGRYVIGASAPVEGGLC 60 Query: 61 QPVQCEGALFGHFVFPPLTRPYSDQERQRLAMLAAFLGRLMQGRADTEQRVRALDQIEAK 120 QPVQCEGALFGHFVFPPLTRPYSDQERQRLAMLAAFLGRLMQGRADTEQRVRALDQIEAK Sbjct: 61 QPVQCEGALFGHFVFPPLTRPYSDQERQRLAMLAAFLGRLMQGRADTEQRVRALDQIEAK 120 Query: 121 LEQQAQILNQMHESVITMDPAGFITSWNRGAEQLFGYSAMEAIGRNVLFLYESEDEEDSL 180 LEQQAQILNQMHESVITMDPAGFITSWNRGAEQLFGYSAMEAIGRNVLFLYE+EDEEDSL Sbjct: 121 LEQQAQILNQMHESVITMDPAGFITSWNRGAEQLFGYSAMEAIGRNVLFLYENEDEEDSL 180 Query: 181 HDLFLEHGGREMEVRRRKKSGEVFWASLSLSVMRDQNGHPIGLIGYLNDITERKNAEKLI 240 HDLFLEHGGREMEVRRRKKSGEVFWASLSLSVMRDQNGHPIGLIGYLNDITERKNAEKLI Sbjct: 181 HDLFLEHGGREMEVRRRKKSGEVFWASLSLSVMRDQNGHPIGLIGYLNDITERKNAEKLI 240 Query: 241 HHLAYYDALTGLPNRTLLTRTVDQALEEARHENLHGCVMFIDLNRFKPINDTLGHVAGDM 300 HHLAYYDALTGLPNRTLLTRTVDQALEEARHENLHGCVMFIDLNRFKPINDTLGHVAGDM Sbjct: 241 HHLAYYDALTGLPNRTLLTRTVDQALEEARHENLHGCVMFIDLNRFKPINDTLGHVAGDM 300 Query: 301 LLVEVAMRLRRALREQDVVARLGADEFAVALFGIDKDSPAYVAQKLLALFDDPFFIDGHE 360 LLVEVAMRLRRALREQDVVARLGADEFAVALFGIDKDSPAYVAQKLLALFDDPFFIDGHE Sbjct: 301 LLVEVAMRLRRALREQDVVARLGADEFAVALFGIDKDSPAYVAQKLLALFDDPFFIDGHE 360 Query: 361 LRVGASIGVSLYPENATDTETLLRLADIAMYRAKQGGENNEGGYACYSEEMNRNTLDLLR 420 LRVGASIGVSLYPENATDTETLLRLADIAMYRAKQGGENNEGGYACYSEEMNRNTLDLLR Sbjct: 361 LRVGASIGVSLYPENATDTETLLRLADIAMYRAKQGGENNEGGYACYSEEMNRNTLDLLR 420 Query: 421 IETGLLHAFEYNELLLYYQPKVDMQTLAITGAEALVRWQHPERGLLLPGEFIPIAEETGL 480 IETGLLHAFEYNELLLYYQPKVDMQTLAITGAEALVRWQHPERGLLLPGEFIPIAEETGL Sbjct: 421 IETGLLHAFEYNELLLYYQPKVDMQTLAITGAEALVRWQHPERGLLLPGEFIPIAEETGL 480 Query: 481 IVQLSDWVLDAVCRQARAWKDAGLPPIRIALNVTAREFTRSLPDRVGAALERHMLSGEWL 540 IVQLSDWVLDAVCRQARAWKDAGLPPIRIALNVTAREFTRSLPDRVGAALERHMLSGEWL Sbjct: 481 IVQLSDWVLDAVCRQARAWKDAGLPPIRIALNVTAREFTRSLPDRVGAALERHMLSGEWL 540 Query: 541 ELEITESMLMHSTDRVISIMEKICGLGITVSLDDFGTGYSSLSYLKRFPINTLKIDRSFT 600 ELEITESMLMHSTDRVISIMEKICGLGITVSLDDFGTGYSSLSYLKRFPINTLKIDRSFT Sbjct: 541 ELEITESMLMHSTDRVISIMEKICGLGITVSLDDFGTGYSSLSYLKRFPINTLKIDRSFT 600 Query: 601 MGIPDDTNDCAIASAIIGIAKQLRHKVIAEGVEDEKQFNFLREAGCNELQGYIFSRPVPA 660 MGIPDDTNDCAIASAIIGIAKQLRHKVIAEGVEDEKQFNFLREAGCNELQGYIFSRPVPA Sbjct: 601 MGIPDDTNDCAIASAIIGIAKQLRHKVIAEGVEDEKQFNFLREAGCNELQGYIFSRPVPA 660 Query: 661 PDFHAMLLEGRKLALESASASQ 682 PDFHAMLLEGRKLALESASASQ Sbjct: 661 PDFHAMLLEGRKLALESASASQ 682 >gb|EGW61550.1| diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Dechlorosoma suillum PS] Length = 833 Score = 511 bits (1317), Expect = e-142, Method: Compositional matrix adjust. Identities = 272/554 (49%), Positives = 358/554 (64%), Gaps = 8/554 (1%) Query: 118 EAKLEQQAQILNQMHESVITMDPAGFITSWNRGAEQLFGYSAMEAIGRNVLFLYESEDEE 177 E KL A+I E+VI D + S N+ + G+S E L + D+ Sbjct: 279 EEKLRLHAKIFEHNSEAVIVTDAMQRVLSVNKAFCDITGFSEAEVRMSLPALLQPTRDDP 338 Query: 178 D---SLHDLFLEHGGREMEVRRRKKSGEVFWASLSLSVMRDQNGHPIGLIGYLNDITERK 234 + + G + E+ R+K+G+ + +S+S +++ G +DI+ERK Sbjct: 339 NLAAEIQVALASSGAWQGELWDRRKNGDTYPVWVSISSVKNTRGILSHYFLVFSDISERK 398 Query: 235 NAEKLIHHLAYYDALTGLPNRTLLTRTVDQALEEARHENLHGCVMFIDLNRFKPINDTLG 294 AE+ I+ LAYYDALTGLPNR+LL ++QAL EA+ HG V+F+DL+RFK IND+ G Sbjct: 399 EAERQIYRLAYYDALTGLPNRSLLFSLLEQALIEAQRNQTHGAVLFVDLDRFKTINDSFG 458 Query: 295 HVAGDMLLVEVAMRLRRALREQDVVARLGADEFAVALFGIDK-DSPAYVAQKLLALFDDP 353 H D LL EVA RL+ LR +DVVARLG DEF VALF I K + A V QK+L +P Sbjct: 459 HAPADALLKEVARRLQETLRAEDVVARLGGDEFIVALFDITKREHAALVGQKILDALAEP 518 Query: 354 FFIDGHELRVGASIGVSLYPENATDTETLLRLADIAMYRAKQGGENNEGGYACYSEEMNR 413 F I HE+ + ASIG++++P++ D ETLLR AD AMYR KQ GG YS+EMN Sbjct: 519 FQIVHHEVLLTASIGIAVFPDDGRDAETLLRNADTAMYRVKQ----TSGGPLFYSQEMNL 574 Query: 414 NTLDLLRIETGLLHAFEYNELLLYYQPKVDMQTLAITGAEALVRWQHPERGLLLPGEFIP 473 +L+ L++E L A E E LYYQP+V++ T I GAEAL+RW HPE+G++ P FIP Sbjct: 575 RSLERLKLEGALRKAVERQEFRLYYQPQVELATGRIVGAEALIRWHHPEQGMIPPTAFIP 634 Query: 474 IAEETGLIVQLSDWVLDAVCRQARAWKDAGLPPIRIALNVTAREFTRSLPDRVGAALERH 533 +AEETGLIV + WVLDA CRQ R W++AG + IA+N++ R+F L V LERH Sbjct: 635 LAEETGLIVSIGAWVLDAACRQGRLWREAGYEDLTIAVNLSPRQFRPGLSQLVNETLERH 694 Query: 534 MLSGEWLELEITESMLMHSTDRVISIMEKICGLGITVSLDDFGTGYSSLSYLKRFPINTL 593 GE LELEITE MLMH+++ VI ++E G+ ++LDDFGTGYSSL+YLK+FPI+ L Sbjct: 695 AFPGENLELEITEGMLMHNSEAVIQMLEDFHQAGVRLALDDFGTGYSSLAYLKKFPIDNL 754 Query: 594 KIDRSFTMGIPDDTNDCAIASAIIGIAKQLRHKVIAEGVEDEKQFNFLREAGCNELQGYI 653 KIDRSF GIP D +D AIA AII +AK LR VIAEGVE E+Q +FLR AGC+E+QGY+ Sbjct: 755 KIDRSFVSGIPHDGDDSAIAKAIISMAKNLRLLVIAEGVETEEQLDFLRAAGCDEIQGYL 814 Query: 654 FSRPVPAPDFHAML 667 FS PVP DF +L Sbjct: 815 FSPPVPVEDFQLLL 828 Score = 162 bits (411), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 95/205 (46%), Positives = 127/205 (61%), Gaps = 7/205 (3%) Query: 50 GASAPVEGGLCQPVQCEGALFGHFVFPPLTRPYSDQERQRLAMLAAFLGRLMQGRADTEQ 109 G A L P+ L G YS E +R LAA L + R Sbjct: 86 GTVATRPDALACPLTFRDMLLGLLAVGGKAEGYSALEHRRFGDLAALLAGALHARQAFNL 145 Query: 110 RVRALDQIEAKLEQQAQILNQMHESVITMDPAGFITSWNRGAEQLFGYSAMEAIGRNVLF 169 R L ++EAK+E+Q+QIL+ +H+SVITMD +G+I WN+GAE+LFGY+A EA+GR++LF Sbjct: 146 RQEDLARMEAKVEEQSQILDHIHDSVITMDLSGYIMGWNKGAERLFGYTAAEAVGRHILF 205 Query: 170 LYES------EDEEDSLHDLFLEHGGREMEVRRRKKSGEVFWASLSLSVMRDQNGHPIGL 223 LY E+E+D ++ FL+HG RE EVRRRKKSGEVFWAS+SLS+ R++ G P GL Sbjct: 206 LYADDGSETLEEEDDLFYNAFLDHGRREFEVRRRKKSGEVFWASVSLSLSRNEAGEPAGL 265 Query: 224 IGYLNDITER-KNAEKLIHHLAYYD 247 IGYL DIT + + EKL H ++ Sbjct: 266 IGYLVDITNQLEREEKLRLHAKIFE 290 >ref|ZP_08775749.1| response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Marichromatium purpuratum 984] gb|EGV21491.1| response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Marichromatium purpuratum 984] Length = 957 Score = 467 bits (1202), Expect = e-129, Method: Compositional matrix adjust. Identities = 266/629 (42%), Positives = 371/629 (58%), Gaps = 49/629 (7%) Query: 77 PLTRPYSDQERQRLAMLAAFLGRLMQGRADTEQRVRALDQI------------------- 117 PLTR + D + RL A L QG + E R R ++ I Sbjct: 330 PLTRLFIDADAPRLER--AISAALTQGYCEIEGRARTINGIRNYRYNGVPVRDKHGEVIG 387 Query: 118 --------------EAKLEQQAQILNQMHESVITMDPAG-FITSWNRGAEQLFGYSAMEA 162 + +L A +L+ HE ++ + G + + N+ ++ GY EA Sbjct: 388 IAGVGQDITERLRDQERLRLAAAVLDNTHEGIMVSNAQGDRLVAVNQAFTEISGYGEDEA 447 Query: 163 IGRNVLFLYESEDEEDSLHDLF---LEHGGREMEVRRRKKSGEVFWASLSLSVMRDQNGH 219 +GR L ++ L+ G + E+ R+++GEVF A L++S +RD+ G Sbjct: 448 LGRAPNLLKSGRHGRQFYQAMWASILQTGHWQGEIWNRRRNGEVFPAWLTISRVRDERGD 507 Query: 220 PIGLIGYLNDITERKNAEKLIHHLAYYDALTGLPNRTLLTRTVDQALEEARHENLHGCVM 279 +G +DI++ K +E + HLA+YDALT LPNR LL ++ A+ A+ E V+ Sbjct: 508 TSNYVGIFSDISQVKQSEARLEHLAHYDALTDLPNRLLLLSRLEHAIHRAKRERSKVAVL 567 Query: 280 FIDLNRFKPINDTLGHVAGDMLLVEVAMRLRRALREQDVVARLGADEFAVALFGIDK-DS 338 FIDL+RFK +ND+LGH GD LL VA RLR +R +D +ARLG DEF + L I++ D Sbjct: 568 FIDLDRFKNVNDSLGHPVGDELLQAVAARLRVRIRSEDTLARLGGDEFVLLLESIERPDE 627 Query: 339 PAYVAQKLLALFDDPF-FIDGHELRVGASIGVSLYPENATDTETLLRLADIAMYRAKQGG 397 +AQ+L+ L +PF G E+ +GASIG+SLYP+N TDT LLR AD MY+AK G Sbjct: 628 AGNLAQQLIDLMAEPFGLTGGREIYLGASIGISLYPDNGTDTTQLLRNADTVMYQAKAQG 687 Query: 398 ENNEGGYACYSEEMNRNTLDLLRIETGLLHAFEYNELLLYYQPKVDMQTLAITGAEALVR 457 N Y Y+E + R L +E+ L A E EL+L+YQP+VDM+T +TG EALVR Sbjct: 688 RNT---YRYYTESLTRAANARLSLESRLRRALEREELVLHYQPQVDMRTTRLTGIEALVR 744 Query: 458 WQHPERGLLLPGEFIPIAEETGLIVQLSDWVLDAVCRQARAWKDAGLPPIRIALNVTARE 517 W+ P GL+ P FIP+AEETGLI+ L WVL + CRQ + W D G PP+ +A+N+++ + Sbjct: 745 WEDPAEGLIPPDRFIPLAEETGLIIPLGAWVLASACRQLQDWIDGGAPPLTLAVNISSHQ 804 Query: 518 FTRSLPD---RVGAALERHMLSGEWLELEITESMLMHSTDRVISIMEKICGLGITVSLDD 574 F + PD V L LS E LELE+TES +M R + I+E + LGI +S+DD Sbjct: 805 FAQ--PDLALHVDRELTASGLSPERLELELTESTIMQHNRRGMEILEALRALGIALSIDD 862 Query: 575 FGTGYSSLSYLKRFPINTLKIDRSFTMGIPDDTNDCAIASAIIGIAKQLRHKVIAEGVED 634 FGTGYSSL+YLKR PI+ LKID+SF GIP+D ND IA+ II +A+ L +V+AEGVE Sbjct: 863 FGTGYSSLAYLKRLPIDKLKIDKSFVQGIPEDRNDAEIAATIIAMARNLNLRVLAEGVET 922 Query: 635 EKQFNFLREAGCNELQGYIFSRPVPAPDF 663 E Q +FL +AGC+ QGY+FSRP+PA +F Sbjct: 923 EAQRDFLHQAGCDAYQGYLFSRPLPAAEF 951 >ref|YP_003051624.1| PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase [Methylovorus glucosetrophus SIP3-4] gb|ACT51097.1| diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Methylovorus glucosetrophus SIP3-4] Length = 1126 Score = 465 bits (1196), Expect = e-128, Method: Compositional matrix adjust. Identities = 253/556 (45%), Positives = 351/556 (63%), Gaps = 10/556 (1%) Query: 118 EAKLEQQAQILNQMHESVITMDPAGFITSWNRGAEQLFGYSAMEAIGR--NVLF--LYES 173 EA L Q+ + E ++ DPA + N+ +Q+ GY E IG+ +V+ L+E+ Sbjct: 559 EADLRLARQVFDNTAEGIVITDPAFRVLEVNQAYQQITGYDKEEIIGKLPSVMQAGLHEA 618 Query: 174 EDEEDSLHDLFLEHGGREMEVRRRKKSGEVFWASLSLSVMRDQNGHPIGLIGYLNDITER 233 E L E G E+ R+KSGE + LS+S + D G + DIT+R Sbjct: 619 AYYEGIWQTLRRE-GQWVGEIWNRRKSGESYPEWLSISQVADAKGSVQNYVAVFTDITQR 677 Query: 234 KNAEKLIHHLAYYDALTGLPNRTLLTRTVDQALEEARHENLHGCVMFIDLNRFKPINDTL 293 K +E+ + LA +DALT LPNR LL +DQAL A+ V+FIDL+RFK INDTL Sbjct: 678 KLSEERLQFLANHDALTHLPNRALLQERIDQALFRAQRNKTAIAVLFIDLDRFKIINDTL 737 Query: 294 GHVAGDMLLVEVAMRLRRALREQDVVARLGADEFAVALFGI-DKDSPAYVAQKLLALFDD 352 GH GDMLL E A RL+ LRE D VAR G DEF V + D D +A+K++A Sbjct: 738 GHQTGDMLLQEAAKRLKECLRETDTVARQGGDEFVVLVEDCGDTDYLNTIARKIMATLAQ 797 Query: 353 PFFIDGHELRVGASIGVSLYPENATDTETLLRLADIAMYRAKQGGENNEGGYACYSEEMN 412 PF + G EL + ASIG+S+YP++ DT +LL+ AD AMYRAK+ G+N + Y+ E N Sbjct: 798 PFILVGRELFISASIGISVYPDDGLDTASLLKHADAAMYRAKESGKNT---FRFYAAEAN 854 Query: 413 RNTLDLLRIETGLLHAFEYNELLLYYQPKVDMQTLAITGAEALVRWQHPERGLLLPGEFI 472 N+++LL +E L A E NE +L+YQPKVD+++ I GAEA+VRWQHPE G+L P +FI Sbjct: 855 TNSVELLTLENNLRRAVERNEFVLHYQPKVDLRSQKIIGAEAVVRWQHPELGMLSPMQFI 914 Query: 473 PIAEETGLIVQLSDWVLDAVCRQARAWKDAGLPPIRIALNVTAREF-TRSLPDRVGAALE 531 P+AEETGLI+ + W++ CRQA W+ +R+A+N++AR+F +L + AL Sbjct: 915 PLAEETGLIIDIGAWIMRESCRQAVEWQQLTGQNVRVAVNLSARQFRDETLRQTIADALT 974 Query: 532 RHMLSGEWLELEITESMLMHSTDRVISIMEKICGLGITVSLDDFGTGYSSLSYLKRFPIN 591 L+ + LELEITESM+MH+ +R +++ LG V +DDFGTGYSS YLK FPI+ Sbjct: 975 ESGLTPDCLELEITESMIMHNAERAREVLQHFHDLGAHVLIDDFGTGYSSFGYLKHFPID 1034 Query: 592 TLKIDRSFTMGIPDDTNDCAIASAIIGIAKQLRHKVIAEGVEDEKQFNFLREAGCNELQG 651 +LKIDRSF IPDD +D AI AII +A L+ KV+AEGVE ++Q FL++ GC+++QG Sbjct: 1035 SLKIDRSFVRDIPDDVDDMAITQAIIAMAHSLQIKVVAEGVETQEQLAFLKKQGCDQIQG 1094 Query: 652 YIFSRPVPAPDFHAML 667 ++FS P+ + DF ML Sbjct: 1095 FLFSEPLHSHDFVRML 1110 >ref|YP_004040252.1| PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase [Methylovorus sp. MP688] gb|ADQ85016.1| diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Methylovorus sp. MP688] Length = 1126 Score = 465 bits (1196), Expect = e-128, Method: Compositional matrix adjust. Identities = 253/556 (45%), Positives = 350/556 (62%), Gaps = 10/556 (1%) Query: 118 EAKLEQQAQILNQMHESVITMDPAGFITSWNRGAEQLFGYSAMEAIGR--NVLF--LYES 173 EA L Q+ + E ++ DPA + N+ +Q+ GY E IG+ +V+ L+E+ Sbjct: 559 EADLRLARQVFDNTAEGIVITDPAFRVLEVNQAYQQITGYDKEEIIGKLPSVMQAGLHEA 618 Query: 174 EDEEDSLHDLFLEHGGREMEVRRRKKSGEVFWASLSLSVMRDQNGHPIGLIGYLNDITER 233 E L E G E+ R+KSGE + LS+S + D G + DIT+R Sbjct: 619 AYYEGIWQTLRRE-GQWVGEIWNRRKSGESYPEWLSISQVADAKGSVQNYVAVFTDITQR 677 Query: 234 KNAEKLIHHLAYYDALTGLPNRTLLTRTVDQALEEARHENLHGCVMFIDLNRFKPINDTL 293 K +E+ + LA +DALT LPNR LL +DQAL A+ V+FIDL+RFK INDTL Sbjct: 678 KLSEERLQFLANHDALTHLPNRALLQERIDQALFRAQRNKTAIAVLFIDLDRFKIINDTL 737 Query: 294 GHVAGDMLLVEVAMRLRRALREQDVVARLGADEFAVALFGI-DKDSPAYVAQKLLALFDD 352 GH GDMLL E A RL+ LRE D VAR G DEF V + D D +A+K++A Sbjct: 738 GHQTGDMLLQEAAKRLKECLRETDTVARQGGDEFVVLVEDCGDTDYLNTIARKIMATLAQ 797 Query: 353 PFFIDGHELRVGASIGVSLYPENATDTETLLRLADIAMYRAKQGGENNEGGYACYSEEMN 412 PF + G EL + ASIG+S+YP++ DT +LL+ AD AMYRAK+ G+N + Y+ E N Sbjct: 798 PFILVGRELFISASIGISVYPDDGLDTASLLKHADAAMYRAKESGKNT---FRFYAAEAN 854 Query: 413 RNTLDLLRIETGLLHAFEYNELLLYYQPKVDMQTLAITGAEALVRWQHPERGLLLPGEFI 472 N+++LL +E L A E NE +L+YQPKVD+++ I GAEA+VRWQHPE G+L P +FI Sbjct: 855 TNSVELLTLENNLRRAVERNEFVLHYQPKVDLRSQKIIGAEAVVRWQHPELGMLSPMQFI 914 Query: 473 PIAEETGLIVQLSDWVLDAVCRQARAWKDAGLPPIRIALNVTAREF-TRSLPDRVGAALE 531 P+AEETGLI+ + W++ CRQA W+ +R+A+N++AR+F +L + AL Sbjct: 915 PLAEETGLIIDIGAWIMQESCRQAVEWQQLTGQNVRVAVNLSARQFRDETLRQTIADALA 974 Query: 532 RHMLSGEWLELEITESMLMHSTDRVISIMEKICGLGITVSLDDFGTGYSSLSYLKRFPIN 591 L+ + LELEITESM+MH+ +R +++ LG V +DDFGTGYSS YLK FPI+ Sbjct: 975 ESGLTPDCLELEITESMIMHNAERAREVLQHFHDLGAHVLIDDFGTGYSSFGYLKHFPID 1034 Query: 592 TLKIDRSFTMGIPDDTNDCAIASAIIGIAKQLRHKVIAEGVEDEKQFNFLREAGCNELQG 651 +LKIDRSF IPDD +D AI AII +A L+ KV+AEGVE ++Q FL++ GC+++QG Sbjct: 1035 SLKIDRSFVRDIPDDVDDMAITQAIIAMAHSLQIKVVAEGVETQEQLAFLKKQGCDQIQG 1094 Query: 652 YIFSRPVPAPDFHAML 667 ++FS P+ DF ML Sbjct: 1095 FLFSEPLHTHDFVRML 1110 >ref|ZP_05072778.1| ggdef domain protein [Campylobacterales bacterium GD 1] gb|EDZ61261.1| ggdef domain protein [Campylobacterales bacterium GD 1] Length = 744 Score = 463 bits (1191), Expect = e-128, Method: Compositional matrix adjust. Identities = 238/577 (41%), Positives = 366/577 (63%), Gaps = 18/577 (3%) Query: 107 TEQRVRALDQIEAKLEQQAQILNQMHESVITMDPAGFITSWNRGAEQLFGYSAMEAIGRN 166 T + + + +++ K QQ QI+ Q+H+SVI+ D G+ITSWN+G++ L Y+ E + ++ Sbjct: 172 THRDITNIQEMQLKYSQQVQIIEQIHDSVISTDLNGYITSWNKGSQILLEYTEEEMLTKH 231 Query: 167 VLFLYESEDE---EDSLHDLFLEHGGREMEVRRRKKSGEVFWASLSLSVMRDQNGHPIGL 223 V L+ ED ++ +L ++HG + R KKSG++ + SLSLS+++D+ G+P L Sbjct: 232 VSSLFLEEDHKALQEGTQEL-IKHGEYHADKRLVKKSGDIIFVSLSLSILKDEKGNPTAL 290 Query: 224 IGYLNDITERKNAEK-------LIHHLAYYDALTGLPNRTLLTRTVDQALEEARHENLHG 276 +GY DIT+RK AE+ ++H+ A++D LT LPNRT ++QA+E+A+ Sbjct: 291 VGYCQDITKRKEAEEKLYEQKNILHYQAHHDELTQLPNRTFFNERLEQAIEKAKRNKTLI 350 Query: 277 CVMFIDLNRFKPINDTLGHVAGDMLLVEVAMRLRRALREQDVVARLGADEFAVAL--FGI 334 + +IDL+ FK IND+LGH GD++L A RL+ +R++D ++RLG DEF + + I Sbjct: 351 ALFYIDLDHFKQINDSLGHEVGDIVLKITAERLKNKIRKEDTLSRLGGDEFTLIIEELNI 410 Query: 335 DKDSPAYVAQKLLALFDDPFFIDGHELRVGASIGVSLYPENATDTETLLRLADIAMYRAK 394 KD + +AQK++ + P +ID H L + +SIG+S+YP++ TD + LL+ AD AMY+AK Sbjct: 411 AKDV-SLLAQKIIEDLEKPIYIDTHTLYISSSIGISIYPDDDTDAKNLLKYADSAMYKAK 469 Query: 395 QGGENNEGGYACYSEEMNRNTLDLLRIETGLLHAFEYNELLLYYQPKVDMQTLAITGAEA 454 + G NN + YS EM + + +E L A + E ++YYQP++D +T + G EA Sbjct: 470 EEGRNN---FQFYSSEMTELAFEHVAMEASLRQALQNEEFVVYYQPQMDGRTDRLVGMEA 526 Query: 455 LVRWQHPERGLLLPGEFIPIAEETGLIVQLSDWVLDAVCRQARAWKDAGLPPIRIALNVT 514 LVRW HP GL+ P +FIPIAE+ GLIVQ+ WV+ + Q AW GL P +A+N+ Sbjct: 527 LVRWNHPTLGLVQPYKFIPIAEKNGLIVQIDQWVMKSAMTQFVAWYKDGLNPGVLAMNLA 586 Query: 515 AREF-TRSLPDRVGAALERHMLSGEWLELEITESMLMHSTDRVISIMEKICGLGITVSLD 573 ++ + D + L+ EW+ELE+TES +M + I I+++I +GI +++D Sbjct: 587 VKQLQKKDFIDTMSNLLKSTQCKPEWIELEVTESQIMTNPQEAIKILKQISEMGIELAVD 646 Query: 574 DFGTGYSSLSYLKRFPINTLKIDRSFTMGIPDDTNDCAIASAIIGIAKQLRHKVIAEGVE 633 DFGTGYSSLSYLKR PI+ LKIDR+F +PDD D I ++I ++K L KVIAEGVE Sbjct: 647 DFGTGYSSLSYLKRLPIDKLKIDRTFIQDLPDDEEDVGITKSVIALSKSLNLKVIAEGVE 706 Query: 634 DEKQFNFLREAGCNELQGYIFSRPVPAPDFHAMLLEG 670 ++Q NFL E GC +QGY++S+P+ A + L+ Sbjct: 707 TDEQKNFLVENGCQNIQGYLYSKPITANEMKERFLKN 743 >gb|EGW59617.1| diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Dechlorosoma suillum PS] Length = 737 Score = 460 bits (1183), Expect = e-127, Method: Compositional matrix adjust. Identities = 248/537 (46%), Positives = 342/537 (63%), Gaps = 9/537 (1%) Query: 144 ITSWNRGAEQLFGYSAMEAIGRNVLFLYESEDEEDSLHDLFLEHGGRE---MEVRRRKKS 200 IT N E++ GYSA E GRN FL + ++ L+++ R +R +K Sbjct: 193 ITYVNPAFERITGYSAAEVQGRNGRFLVRDDLQQKGLNEIRAALRDRREGHAILRNYRKD 252 Query: 201 GEVFWASLSLSVMRDQNGHPIG-LIGYLNDITERKNAEKLIHHLAYYDALTGLPNRTLLT 259 G +FW L L+ + D++G + +ND+++R + ++ + + A +D LTGL NR+LL Sbjct: 253 GSLFWNELHLAPVLDESGQSTTHFVSVINDVSDRIHYQEQLEYQATHDVLTGLANRSLLA 312 Query: 260 RTVDQALEEARHENLHGCVMFIDLNRFKPINDTLGHVAGDMLLVEVAMRLRRALREQDVV 319 + QA+ AR + VM +DL+RFK IND LGH D LL VA RL+ A+R+ D V Sbjct: 313 DRISQAIALARRDRRLVGVMLLDLDRFKVINDGLGHAPADKLLKTVAERLQTAVRDTDTV 372 Query: 320 ARLGADEFAVALFGI-DKDSPAYVAQKLLALFDDPFFIDGHELRVGASIGVSLYPENATD 378 ARLG DEF + + I D D A VA K+ P F++G EL V ASIGVSL+P + Sbjct: 373 ARLGGDEFVIVVGDILDADDVAVVAGKIQRALAQPLFVEGKELFVTASIGVSLFPRDGET 432 Query: 379 TETLLRLADIAMYRAKQGGENNEGGYACYSEEMNRNTLDLLRIETGLLHAFEYNELLLYY 438 + LLR AD+AMYR K+ G NN Y Y EM+ LD L +E L A E +E +YY Sbjct: 433 GDILLRNADVAMYRVKEYGRNN---YRFYLPEMSSMALDRLDMEGNLRRALETDEFQVYY 489 Query: 439 QPKVDMQTLAITGAEALVRWQHPERGLLLPGEFIPIAEETGLIVQLSDWVLDAVCRQARA 498 QPKV +Q I GAEAL+RW HP G + P EFIP+AEE+GLI+ L + V++ VCRQ RA Sbjct: 490 QPKVSLQQGTIVGAEALLRWMHPRIGQINPNEFIPLAEESGLIIPLGEKVIELVCRQIRA 549 Query: 499 WKDAGLPPIRIALNVTAREFTR-SLPDRVGAALERHMLSGEWLELEITESMLMHSTDRVI 557 W++ GLPP+++A+N++AR+F + +L + V LE + + GE L++E+TESM+MH TD Sbjct: 550 WREEGLPPLKVAINISARQFRQENLGETVRRLLEEYQVPGEMLDIELTESMVMHDTDHAA 609 Query: 558 SIMEKICGLGITVSLDDFGTGYSSLSYLKRFPINTLKIDRSFTMGIPDDTNDCAIASAII 617 + ++ LG+T+SLDDFGTGYSSLSYLKRFPI+ LKIDRSF I + +D AIASA+I Sbjct: 610 LTLRELKDLGVTLSLDDFGTGYSSLSYLKRFPIDCLKIDRSFVRDINSNADDAAIASAVI 669 Query: 618 GIAKQLRHKVIAEGVEDEKQFNFLREAGCNELQGYIFSRPVPAPDFHAMLLEGRKLA 674 +A L V+AEGVE +Q LR+ GC+E QGY FSR VPA D+ +L +G+ LA Sbjct: 670 AMAHSLGLNVVAEGVETAEQLALLRQHGCDEFQGYFFSRAVPAGDYALLLRQGKTLA 726 >ref|YP_356762.1| EAL and GGDEF domain-containing protein [Pelobacter carbinolicus DSM 2380] gb|ABA88592.1| response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Pelobacter carbinolicus DSM 2380] Length = 1274 Score = 459 bits (1180), Expect = e-126, Method: Compositional matrix adjust. Identities = 250/563 (44%), Positives = 348/563 (61%), Gaps = 12/563 (2%) Query: 116 QIEAKLEQQAQILNQMHESVITMDPAGFITSWNRGAEQLFGYSAMEAIGRNVLFLYESED 175 Q E++L++ ++ + Q SV+ DP G I N QL GY+ E I +N L +S + Sbjct: 681 QSESQLKKLSRAIEQSPVSVVITDPEGRIEYVNPKFTQLTGYTLEEVIAQNPRIL-KSGN 739 Query: 176 EEDSLHDLFLEH--GGREM--EVRRRKKSGEVFWASLSLSVMRDQNGHPIGLIGYLNDIT 231 S++D + G+E E+ ++K G +FW S S+S + D++G I IG DIT Sbjct: 740 LLPSVYDSLWKTITSGKEWYGELENKRKDGSIFWESASISPLFDESGKIINFIGVKEDIT 799 Query: 232 ERKNAEKLIHHLAYYDALTGLPNRTLLTRTVDQALEEARHENLHGCVMFIDLNRFKPIND 291 +RK EK + ++A +D LTGL NRTLL ++ AL +++ V+ +DL+RFK IND Sbjct: 800 QRKLNEKRLEYMATHDGLTGLANRTLLYDHLEIALHQSQRSKKLVAVILLDLDRFKVIND 859 Query: 292 TLGHVAGDMLLVEVAMRLRRALREQDVVARLGADEFAVALFGI-DKDSPAYVAQKLLALF 350 +LGH+ GD +L V RL++ +R D VARLG DEF V L + D + +A LL Sbjct: 860 SLGHLVGDQVLKAVGQRLKQYVRSTDTVARLGGDEFVVLLTDVRDTTAAGKIAHNLLRKL 919 Query: 351 DDPFFIDGHELRVGASIGVSLYPENATDTETLLRLADIAMYRAKQGGENNEGGYACYSEE 410 ++PFF+ G EL V AS G+ L + D LLR ADIAMY+AK G G YS E Sbjct: 920 NEPFFLHGRELYVSASFGICLSETDNVDGTILLRNADIAMYKAKAEG----CGLYFYSHE 975 Query: 411 MNRNTLDLLRIETGLLHAFEYNELLLYYQPKVDMQTLAITGAEALVRWQHPERGLLLPGE 470 MN + + L +E L A E NE LYYQPKV+ T I G EAL+RW+HP+RG++ P E Sbjct: 976 MNEHLIKTLEMENSLRQALEKNEFQLYYQPKVEHATGRIIGCEALLRWRHPQRGMIPPSE 1035 Query: 471 FIPIAEETGLIVQLSDWVLDAVCRQARAWKDAGLPPIRIALNVTAREFTR--SLPDRVGA 528 FIP+AEETGLIVQ+ WVL CRQ++ W+ GLPP+ +A+N++AR+F + +L V + Sbjct: 1036 FIPLAEETGLIVQIGHWVLAEACRQSKIWETEGLPPLTMAVNISARQFYQGENLIQAVKS 1095 Query: 529 ALERHMLSGEWLELEITESMLMHSTDRVISIMEKICGLGITVSLDDFGTGYSSLSYLKRF 588 LER L LELE+TESM+M M KI LG+++SLDDFGTGYSSL+YL+ F Sbjct: 1096 TLERSQLVPSQLELELTESMVMKDAVNAERTMRKIKQLGVSLSLDDFGTGYSSLNYLRSF 1155 Query: 589 PINTLKIDRSFTMGIPDDTNDCAIASAIIGIAKQLRHKVIAEGVEDEKQFNFLREAGCNE 648 P+++LKIDRSF + I D + AI ++II IA L + +AEGVE+ Q + GCN Sbjct: 1156 PVDSLKIDRSFILDIASDASSAAILNSIIAIAHTLGLQTVAEGVENNDQLALVANCGCNY 1215 Query: 649 LQGYIFSRPVPAPDFHAMLLEGR 671 +QGY+FSRP+P DF A+ L + Sbjct: 1216 IQGYLFSRPLPPEDFVALFLANK 1238 >gb|EGW62852.1| diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) [Dechlorosoma suillum PS] Length = 874 Score = 455 bits (1170), Expect = e-125, Method: Compositional matrix adjust. Identities = 251/577 (43%), Positives = 348/577 (60%), Gaps = 14/577 (2%) Query: 98 GRLMQGRA---DTEQRVRALDQIEAKLEQQAQILNQMHESVITMDPAGFITSWNRGAEQL 154 G+L+ G A D +R RA E +L Q ++ + Q +++ D G I N + Sbjct: 300 GQLLGGIAIVEDATERKRA----ELQLRQLSRAVEQSPATIVITDTNGVIEYVNPKFTRT 355 Query: 155 FGYSAMEAIGRNVLFLYESEDEEDSLHDLF--LEHGGR-EMEVRRRKKSGEVFWASLSLS 211 GYSA EA+G L E + +L+ + GG+ E R+++GE++W ++S Sbjct: 356 TGYSAEEAVGLKPSVLKSGETPLEVYQELWSTIASGGQWEGVFHNRRRNGELYWEHATIS 415 Query: 212 VMRDQNGHPIGLIGYLNDITERKNAEKLIHHLAYYDALTGLPNRTLLTRTVDQALEEARH 271 + D N + DITE++ E IH LAY+D LTGLPNRTLL V Q L A Sbjct: 416 PITDDNQRITHFVAVKEDITEKRRQEDRIHQLAYFDELTGLPNRTLLHDRVSQCLAAAER 475 Query: 272 ENLHGCVMFIDLNRFKPINDTLGHVAGDMLLVEVAMRLRRALREQDVVARLGADEFAVAL 331 E ++FIDL+ FK +ND+LGH GD LL VA RL+ +R+ D V+RLG DEF V L Sbjct: 476 EQETLALLFIDLDNFKTVNDSLGHFTGDRLLQSVAQRLKGCVRDSDTVSRLGGDEFVVVL 535 Query: 332 FGIDKDSPAYVAQKLLALFDDPFFIDGHELRVGASIGVSLYPENATDTETLLRLADIAMY 391 D + VA+K++ PF IDGH+L V SIG+SL+P +A D ++LL+ AD AMY Sbjct: 536 ADAQLDGASQVARKIIDRVGQPFVIDGHQLTVTPSIGISLFPHDARDFQSLLKNADTAMY 595 Query: 392 RAKQGGENNEGGYACYSEEMNRNTLDLLRIETGLLHAFEYNELLLYYQPKVDMQTLAITG 451 +AK+ G N Y ++ EMN + L +E L A E E +L+YQP+VDM + + G Sbjct: 596 QAKESGRN---AYQFFTAEMNVLAFERLVLENALRQAVERQEFVLHYQPQVDMGSGRVIG 652 Query: 452 AEALVRWQHPERGLLLPGEFIPIAEETGLIVQLSDWVLDAVCRQARAWKDAGLPPIRIAL 511 AEALVRW HPE G++ P FIP+AE++GLI + DWVL CRQ RAW++AGLP I +A+ Sbjct: 653 AEALVRWLHPELGMVPPARFIPVAEDSGLIGAIGDWVLYEACRQNRAWQEAGLPAIPVAV 712 Query: 512 NVTAREFTRS-LPDRVGAALERHMLSGEWLELEITESMLMHSTDRVISIMEKICGLGITV 570 N++A + +S L + V L R L +LELE+TE +M + + + ++ +G+ + Sbjct: 713 NLSAVQLRQSELHESVAELLRRTGLESRYLELELTERTVMEDAEATVRCLRRLDEMGVML 772 Query: 571 SLDDFGTGYSSLSYLKRFPINTLKIDRSFTMGIPDDTNDCAIASAIIGIAKQLRHKVIAE 630 S+DDFGTGYSSLSYLKRFPI+ LKID+SF I D +D AIA AII + LR +VIAE Sbjct: 773 SIDDFGTGYSSLSYLKRFPIDKLKIDQSFVRDIVADADDQAIAVAIISMGHSLRLRVIAE 832 Query: 631 GVEDEKQFNFLREAGCNELQGYIFSRPVPAPDFHAML 667 GVE +Q L GC+E QG+ F RP+PA +F A L Sbjct: 833 GVETAEQLEILHRHGCDEAQGFHFGRPMPADEFAAYL 869 >ref|YP_003640479.1| diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Thermincola sp. JR] gb|ADG82578.1| diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Thermincola potens JR] Length = 798 Score = 454 bits (1169), Expect = e-125, Method: Compositional matrix adjust. Identities = 238/572 (41%), Positives = 352/572 (61%), Gaps = 16/572 (2%) Query: 105 ADTEQRVRALDQIEAKLEQQAQILNQMHESVITMDPAGFITSWNRGAEQLFGYSAMEAIG 164 +D +AL+++ + + +++ ++ G IT +N+ AE+L GY+A E IG Sbjct: 202 SDITDSKQALEELRQERDFSQSLVDNARTIIMLWAMDGTITLFNKYAEELTGYTAAEVIG 261 Query: 165 RNVLFLYESEDEEDSLHDLF--LEHG-----GREMEVRRRKKSGEVFWASLSLSVMRDQN 217 + ++ ++ + ++ +L + G G + + E+ W ++ D Sbjct: 262 KKWWEIFTPKEIKPAIPELLERFQQGEVIETGEHPWIAKDGGRIEILWTH---TLSYDAE 318 Query: 218 GHPIGLIGYLNDITERKNAEKLIHHLAYYDALTGLPNRTLLTRTVDQALEEARHENLHGC 277 G P+ +I DIT+RK AE++I+H+AY+D LT LPNR L + AL A+ Sbjct: 319 GKPLAIISMGIDITDRKRAEEIINHMAYHDPLTDLPNRALFNDRLKLALAHAKRNKQLLA 378 Query: 278 VMFIDLNRFKPINDTLGHVAGDMLLVEVAMRLRRALREQDVVARLGADEFAVALFGIDKD 337 VMFIDL+RFK INDTLGH GD +L +VA RL LRE D VAR+G DEF + I K+ Sbjct: 379 VMFIDLDRFKLINDTLGHAMGDRVLKDVAQRLTECLREGDTVARIGGDEFILIFPQIAKE 438 Query: 338 SP-AYVAQKLLALFDDPFFIDGHELRVGASIGVSLYPENATDTETLLRLADIAMYRAKQG 396 A +A K++ PF ++ E + SIGV++YP + D ETL++ AD A+Y AK+ Sbjct: 439 QDVAKIALKIIETMKRPFKVEMQEFHLTTSIGVAIYPHDGQDAETLVKNADSALYLAKEQ 498 Query: 397 GENNEGGYACYSEEMNRNTLDLLRIETGLLHAFEYNELLLYYQPKVDMQTLAITGAEALV 456 G Y Y+ MN + L E L A E +E ++YQP+V++ T ITG EALV Sbjct: 499 GNT----YQLYTPSMNDKAYERLNTEQALCKALENDEFEVHYQPQVNIITGQITGMEALV 554 Query: 457 RWQHPERGLLLPGEFIPIAEETGLIVQLSDWVLDAVCRQARAWKDAGLPPIRIALNVTAR 516 RW+HPE+GL+ PG+FI IAEETGLI+ + +WVL C Q++AW+DAG PP+ + +N++AR Sbjct: 555 RWKHPEKGLVYPGDFIQIAEETGLIIPIGEWVLRTACLQSKAWQDAGYPPVTVVVNLSAR 614 Query: 517 EF-TRSLPDRVGAALERHMLSGEWLELEITESMLMHSTDRVISIMEKICGLGITVSLDDF 575 +F ++L + + L+ + +WLELEITE ++M D + +++++ +GI +++DDF Sbjct: 615 QFLQQNLVETITRILQETGMDPKWLELEITEGVIMKDVDYTVKVLQELAKMGIRIAIDDF 674 Query: 576 GTGYSSLSYLKRFPINTLKIDRSFTMGIPDDTNDCAIASAIIGIAKQLRHKVIAEGVEDE 635 GTGYSSL+YLKRFPINTLKIDRSF G+ D D AI S II +A+ L KV+AEGVE E Sbjct: 675 GTGYSSLNYLKRFPINTLKIDRSFIQGVVSDIQDAAIVSTIIVLARNLNLKVVAEGVETE 734 Query: 636 KQFNFLREAGCNELQGYIFSRPVPAPDFHAML 667 +Q+ FLR C ++QGY FSRPVPA +F +L Sbjct: 735 EQYLFLRGKQCYDMQGYWFSRPVPAEEFEGLL 766