BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0471.p (254 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003778115.1| GTP cyclohydrolase I protein [Herbaspirillum... 525 e-147 ref|YP_001790862.1| GTP cyclohydrolase I [Leptothrix cholodnii S... 387 e-105 ref|NP_902031.1| GTP cyclohydrolase I [Chromobacterium violaceum... 374 e-102 ref|YP_001020270.1| GTP cyclohydrolase [Methylibium petroleiphil... 374 e-102 ref|YP_004682120.1| hypothetical protein CNE_2c19320 [Cupriavidu... 362 2e-98 ref|YP_841479.1| GTP cyclohydrolase I [Ralstonia eutropha H16] >... 361 7e-98 ref|ZP_08400850.1| GTP cyclohydrolase I [Rubrivivax benzoatilyti... 360 1e-97 ref|YP_002008316.1| GTP cyclohydrolase i [Cupriavidus taiwanensi... 359 2e-97 ref|YP_004620236.1| GTP cyclohydrolase I [Ramlibacter tataouinen... 359 3e-97 ref|YP_547723.1| GTP cyclohydrolase [Polaromonas sp. JS666] >gi|... 357 7e-97 >ref|YP_003778115.1| GTP cyclohydrolase I protein [Herbaspirillum seropedicae SmR1] gb|ADJ66207.1| GTP cyclohydrolase I protein [Herbaspirillum seropedicae SmR1] Length = 254 Score = 525 bits (1353), Expect = e-147, Method: Compositional matrix adjust. Identities = 253/254 (99%), Positives = 254/254 (100%) Query: 1 LARPHSIMATEKKPAQAIQDVAAPSVHEQLVSARIRQRIKAAGVRFHANDNISAFIKEGE 60 +ARPHSIMATEKKPAQAIQDVAAPSVHEQLVSARIRQRIKAAGVRFHANDNISAFIKEGE Sbjct: 1 MARPHSIMATEKKPAQAIQDVAAPSVHEQLVSARIRQRIKAAGVRFHANDNISAFIKEGE 60 Query: 61 LAELQAEVQGKLAAVLESLVIDVESDHNTQDTAKRVAKMYLNEVFKGRYQAAPPVTEFPN 120 LAELQAEVQGKLAAVLESLVIDVESDHNTQDTAKRVAKMYLNEVFKGRYQAAPPVTEFPN Sbjct: 61 LAELQAEVQGKLAAVLESLVIDVESDHNTQDTAKRVAKMYLNEVFKGRYQAAPPVTEFPN 120 Query: 121 IERLNELMIVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQ 180 IERLNELMIVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQ Sbjct: 121 IERLNELMIVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQ 180 Query: 181 IQEEAVSQAADLLMQKLQPDGLAIVMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANL 240 IQEEAVSQAADLLMQKLQPDGLAIVMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANL Sbjct: 181 IQEEAVSQAADLLMQKLQPDGLAIVMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANL 240 Query: 241 RREFLALITQRQRG 254 RREFLALITQRQRG Sbjct: 241 RREFLALITQRQRG 254 >ref|YP_001790862.1| GTP cyclohydrolase I [Leptothrix cholodnii SP-6] gb|ACB34097.1| GTP cyclohydrolase I [Leptothrix cholodnii SP-6] Length = 250 Score = 387 bits (993), Expect = e-105, Method: Compositional matrix adjust. Identities = 184/247 (74%), Positives = 207/247 (83%), Gaps = 7/247 (2%) Query: 7 IMATEKKPA-QAIQDVAAPSVHEQLVSARIRQRIKAAGVRFHANDNISAFIKEGELAELQ 65 I+A E+ A Q D P VS RIR+RIKAA RFHANDNI+ FI+ GEL L Sbjct: 9 ILAAERGLAVQETDDSGVP------VSVRIRERIKAARQRFHANDNIAEFIRPGELEALL 62 Query: 66 AEVQGKLAAVLESLVIDVESDHNTQDTAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLN 125 EV GK++AVL SLVID ESDHNTQDTA+RVAKMYL EVF+GRY PPVTEFPN+ERLN Sbjct: 63 DEVSGKMSAVLSSLVIDTESDHNTQDTARRVAKMYLKEVFRGRYVEQPPVTEFPNVERLN 122 Query: 126 ELMIVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEA 185 ELMIVGP+TVRSACSHHLCPI+GK+W+GVMPNEHSNLIGLSKYARL EW+MSRPQIQEEA Sbjct: 123 ELMIVGPVTVRSACSHHLCPIVGKLWIGVMPNEHSNLIGLSKYARLAEWIMSRPQIQEEA 182 Query: 186 VSQAADLLMQKLQPDGLAIVMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFL 245 V+Q ADLL K+QPDGLA+VMEADHFCM WRGVKDMDSKMINSVMRGSFL+D NLRREFL Sbjct: 183 VTQVADLLQDKMQPDGLAVVMEADHFCMSWRGVKDMDSKMINSVMRGSFLKDPNLRREFL 242 Query: 246 ALITQRQ 252 +L+ ++ Sbjct: 243 SLLQHKK 249 >ref|NP_902031.1| GTP cyclohydrolase I [Chromobacterium violaceum ATCC 12472] gb|AAQ60033.1| GTP cyclohydrolase I [Chromobacterium violaceum ATCC 12472] Length = 232 Score = 374 bits (960), Expect = e-102, Method: Compositional matrix adjust. Identities = 171/222 (77%), Positives = 198/222 (89%) Query: 27 HEQLVSARIRQRIKAAGVRFHANDNISAFIKEGELAELQAEVQGKLAAVLESLVIDVESD 86 ++ +S RIR R++AAG RFHANDNISAFI++GEL LQ EVQ KL VLESLVID +D Sbjct: 9 QQEAISQRIRYRLQAAGARFHANDNISAFIEDGELDALQEEVQAKLKGVLESLVIDTAND 68 Query: 87 HNTQDTAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLCPI 146 HNTQ+TAKRVAKM++ EVF+GRY + PP TEFPN+E LNELMI+GPITVRSACSHHLCPI Sbjct: 69 HNTQETAKRVAKMFVREVFRGRYVSMPPCTEFPNVEHLNELMIIGPITVRSACSHHLCPI 128 Query: 147 MGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVM 206 +G+VWVGV+PNE SNLIGLSKYARL++WVM+RPQIQEEAVSQ ADLLMQKLQPDGLAIVM Sbjct: 129 IGRVWVGVLPNEASNLIGLSKYARLIDWVMTRPQIQEEAVSQIADLLMQKLQPDGLAIVM 188 Query: 207 EADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALI 248 EADHFCMHWRGVKD +SKM NSVMRGSFL + +LR+EFL+L+ Sbjct: 189 EADHFCMHWRGVKDSNSKMTNSVMRGSFLTNPDLRKEFLSLM 230 >ref|YP_001020270.1| GTP cyclohydrolase [Methylibium petroleiphilum PM1] gb|ABM94035.1| GTP cyclohydrolase [Methylibium petroleiphilum PM1] Length = 243 Score = 374 bits (959), Expect = e-102, Method: Compositional matrix adjust. Identities = 173/231 (74%), Positives = 196/231 (84%) Query: 22 AAPSVHEQLVSARIRQRIKAAGVRFHANDNISAFIKEGELAELQAEVQGKLAAVLESLVI 81 A P VS +IR+RIK+ RFHANDNI+ FI+ GEL +L EV GK+ VL+SLVI Sbjct: 12 AVPDDEGVPVSVKIRERIKSQRERFHANDNIAEFIEPGELEQLLDEVAGKMRGVLDSLVI 71 Query: 82 DVESDHNTQDTAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNELMIVGPITVRSACSH 141 D ESDHNTQDTA+RVAKMYLNEVFKGRY P VTEFPN+E LNELMI+GPITVRSACSH Sbjct: 72 DTESDHNTQDTARRVAKMYLNEVFKGRYVHEPAVTEFPNVEHLNELMIIGPITVRSACSH 131 Query: 142 HLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDG 201 H CPIMG+VW+GVMPNEHSNLIGLSKYARL EW+MSRPQIQEEAV+Q ADLL K+ PDG Sbjct: 132 HFCPIMGRVWIGVMPNEHSNLIGLSKYARLTEWIMSRPQIQEEAVTQVADLLQDKMSPDG 191 Query: 202 LAIVMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQRQ 252 LAIVMEADHFCM WRGV+D+DSKMINSVMRG FL+DANLRREFL+L+ ++ Sbjct: 192 LAIVMEADHFCMQWRGVRDLDSKMINSVMRGVFLKDANLRREFLSLVNNKK 242 >ref|YP_004682120.1| hypothetical protein CNE_2c19320 [Cupriavidus necator N-1] gb|AEI80888.1| GTP cyclohydrolase FolE [Cupriavidus necator N-1] Length = 294 Score = 362 bits (930), Expect = 2e-98, Method: Compositional matrix adjust. Identities = 169/244 (69%), Positives = 201/244 (82%), Gaps = 2/244 (0%) Query: 9 ATEKKPAQAIQDVAAPSVHEQLVSARIRQRIKAAGVRFHANDNISAFIKEGELAELQAEV 68 A K + A D P H VSARIR R++AA RFHANDNI+ +I+ GE+ +LQAEV Sbjct: 52 AHRAKDSNAGDDAGHPHTHS--VSARIRARLEAAQERFHANDNIAHYIEPGEMEQLQAEV 109 Query: 69 QGKLAAVLESLVIDVESDHNTQDTAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNELM 128 Q +L VL +LVIDV++DHNTQ+TA+RVAKMYL E+F GRY APPVTEFPN+ +LNELM Sbjct: 110 QTRLEDVLRALVIDVDNDHNTQETARRVAKMYLKEIFAGRYAKAPPVTEFPNVGQLNELM 169 Query: 129 IVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQ 188 IVGP+ VRSACSHHLCPI+GK+WVGVMPN+HSNLIGLSKYARL EW+M RPQIQEEAV+Q Sbjct: 170 IVGPLRVRSACSHHLCPIIGKLWVGVMPNQHSNLIGLSKYARLAEWIMCRPQIQEEAVAQ 229 Query: 189 AADLLMQKLQPDGLAIVMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALI 248 ADLL +K+ PDGLAIVMEA+HFCMHWRGV+D D+KM NSVMRGSFL+D +LRREFL L+ Sbjct: 230 VADLLQEKMNPDGLAIVMEAEHFCMHWRGVRDTDAKMTNSVMRGSFLKDDSLRREFLTLL 289 Query: 249 TQRQ 252 + Sbjct: 290 NHNR 293 >ref|YP_841479.1| GTP cyclohydrolase I [Ralstonia eutropha H16] emb|CAJ96749.1| GTP cyclohydrolase I [Ralstonia eutropha H16] Length = 249 Score = 361 bits (926), Expect = 7e-98, Method: Compositional matrix adjust. Identities = 170/244 (69%), Positives = 200/244 (81%), Gaps = 2/244 (0%) Query: 9 ATEKKPAQAIQDVAAPSVHEQLVSARIRQRIKAAGVRFHANDNISAFIKEGELAELQAEV 68 A K + A D P H VSARIR R++AA RFHANDNIS I+ GE+ +LQAEV Sbjct: 7 AHRAKDSNAGDDAGHP--HAPSVSARIRARLEAAQERFHANDNISHHIEPGEMEQLQAEV 64 Query: 69 QGKLAAVLESLVIDVESDHNTQDTAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNELM 128 Q +L VL +LVIDV++DHNTQ+TA+RVAKMYL E+F GRY APPVTEFPN+ +LNELM Sbjct: 65 QARLEDVLRALVIDVDNDHNTQETARRVAKMYLKEIFAGRYAKAPPVTEFPNVGQLNELM 124 Query: 129 IVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQ 188 IVGP+ VRSACSHHLCPI+GK+WVGVMPN+HSNLIGLSKYARL EW+M RPQIQEEAV+Q Sbjct: 125 IVGPLRVRSACSHHLCPIIGKLWVGVMPNQHSNLIGLSKYARLAEWIMCRPQIQEEAVAQ 184 Query: 189 AADLLMQKLQPDGLAIVMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALI 248 ADLL +K+ PDGLAIVMEA+HFCMHWRGV+D D+KM NSVMRGSFL+D +LRREFL L+ Sbjct: 185 VADLLQEKMNPDGLAIVMEAEHFCMHWRGVRDTDAKMTNSVMRGSFLKDDSLRREFLTLL 244 Query: 249 TQRQ 252 + Sbjct: 245 NHNR 248 >ref|ZP_08400850.1| GTP cyclohydrolase I [Rubrivivax benzoatilyticus JA2] gb|EGJ09183.1| GTP cyclohydrolase I [Rubrivivax benzoatilyticus JA2] Length = 249 Score = 360 bits (924), Expect = 1e-97, Method: Compositional matrix adjust. Identities = 162/222 (72%), Positives = 193/222 (86%) Query: 31 VSARIRQRIKAAGVRFHANDNISAFIKEGELAELQAEVQGKLAAVLESLVIDVESDHNTQ 90 VS RIR R+ A RFHANDNI+ F++EGEL EL+ EVQ KL +L +LVID ESDHNTQ Sbjct: 27 VSERIRYRLVCADKRFHANDNIADFVREGELPELKKEVQAKLEELLRALVIDTESDHNTQ 86 Query: 91 DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLCPIMGKV 150 +TAKRVAKMY++EVF+GR+ P VTEFPN ERLNELMIVGPITVRSACSHHLCPI GKV Sbjct: 87 ETAKRVAKMYIDEVFRGRFHPMPSVTEFPNAERLNELMIVGPITVRSACSHHLCPIFGKV 146 Query: 151 WVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEADH 210 W+G++PNEHSNLIGLSKYAR+ +W+MSRPQIQEEAV+ A+ L ++++PDGLAIVMEADH Sbjct: 147 WIGLLPNEHSNLIGLSKYARITDWIMSRPQIQEEAVTMLANELQERVRPDGLAIVMEADH 206 Query: 211 FCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQRQ 252 FCMHWRGVKD DS M+NSVMRG+FL+D NLRREFL+L+ ++Q Sbjct: 207 FCMHWRGVKDTDSAMVNSVMRGAFLKDPNLRREFLSLLPRKQ 248 >ref|YP_002008316.1| GTP cyclohydrolase i [Cupriavidus taiwanensis LMG 19424] emb|CAQ72262.1| GTP cyclohydrolase I [Cupriavidus taiwanensis LMG 19424] Length = 248 Score = 359 bits (922), Expect = 2e-97, Method: Compositional matrix adjust. Identities = 162/220 (73%), Positives = 193/220 (87%) Query: 31 VSARIRQRIKAAGVRFHANDNISAFIKEGELAELQAEVQGKLAAVLESLVIDVESDHNTQ 90 VSARIR R++AA RFHANDNI+ +I+ GE+ +LQAEVQ +L VL +LVIDV++DHNTQ Sbjct: 26 VSARIRARLEAAQERFHANDNIARYIEPGEMEQLQAEVQARLQDVLRALVIDVDNDHNTQ 85 Query: 91 DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLCPIMGKV 150 +TA+RVAKMYL E+F GRY APPVTEFPN+ +LNELMIVGP+ VRSACSHHLCPI+GK+ Sbjct: 86 ETARRVAKMYLKEIFAGRYAKAPPVTEFPNVGQLNELMIVGPLRVRSACSHHLCPIIGKL 145 Query: 151 WVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEADH 210 W+GVMPN+HSNLIGLSKYARL EW+M RPQIQEEAV+Q ADLL +K+ PDGLAIVMEA+H Sbjct: 146 WIGVMPNQHSNLIGLSKYARLAEWIMCRPQIQEEAVAQVADLLQEKMSPDGLAIVMEAEH 205 Query: 211 FCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQ 250 FCMHWRGV+D D+KM NSVMRGSFL+D +LRREFL L+ Sbjct: 206 FCMHWRGVRDTDAKMTNSVMRGSFLKDDSLRREFLTLLNH 245 >ref|YP_004620236.1| GTP cyclohydrolase I [Ramlibacter tataouinensis TTB310] gb|AEG94217.1| GTP cyclohydrolase I-like protein [Ramlibacter tataouinensis TTB310] Length = 245 Score = 359 bits (921), Expect = 3e-97, Method: Compositional matrix adjust. Identities = 166/220 (75%), Positives = 189/220 (85%) Query: 31 VSARIRQRIKAAGVRFHANDNISAFIKEGELAELQAEVQGKLAAVLESLVIDVESDHNTQ 90 VS +IR+RI+AA RFHANDNI+ F++ GEL L EV+ K+ VL+SLVID +SDHNT Sbjct: 25 VSVKIRERIRAARKRFHANDNIADFVQPGELEALLDEVETKMQGVLDSLVIDTQSDHNTG 84 Query: 91 DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLCPIMGKV 150 DTA+RVAKMYLNEVFKGRY P +TEFPN E LNELMIVGPITVRSACSHH CP++GKV Sbjct: 85 DTARRVAKMYLNEVFKGRYVKPPSITEFPNAEHLNELMIVGPITVRSACSHHFCPVIGKV 144 Query: 151 WVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEADH 210 W+GVMPNEH+N+IGLSKYARL EWVM RPQIQEEAV Q ADL+M+K QPDGLAIVMEA H Sbjct: 145 WIGVMPNEHTNVIGLSKYARLAEWVMGRPQIQEEAVVQLADLIMEKTQPDGLAIVMEATH 204 Query: 211 FCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQ 250 +CM WRGVKDMDSKMINSVMRG FL+D+ LRREFLALI + Sbjct: 205 YCMAWRGVKDMDSKMINSVMRGVFLKDSALRREFLALIPK 244 >ref|YP_547723.1| GTP cyclohydrolase [Polaromonas sp. JS666] gb|ABE42825.1| GTP cyclohydrolase I [Polaromonas sp. JS666] Length = 240 Score = 357 bits (917), Expect = 7e-97, Method: Compositional matrix adjust. Identities = 165/221 (74%), Positives = 188/221 (85%) Query: 31 VSARIRQRIKAAGVRFHANDNISAFIKEGELAELQAEVQGKLAAVLESLVIDVESDHNTQ 90 VS +IR+R+ A RFHANDNI+AFI+ GEL +L EV+ K+ VL+SLVID DHNT Sbjct: 19 VSVKIRERLHQARKRFHANDNIAAFIEPGELEKLLDEVEVKMQTVLDSLVIDTAGDHNTN 78 Query: 91 DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLCPIMGKV 150 +TA+RVAKMYLNEVFKGRY P +TEFPN E LNELMIVGPITVRSACSHH CP++GK+ Sbjct: 79 NTARRVAKMYLNEVFKGRYVQPPTITEFPNAEHLNELMIVGPITVRSACSHHFCPVIGKI 138 Query: 151 WVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEADH 210 W+GVMPNEH+N+IGLSKYARL EWVM RPQIQEEAV Q ADL+M+K QPDGLAIVMEA H Sbjct: 139 WIGVMPNEHTNVIGLSKYARLAEWVMGRPQIQEEAVVQLADLIMEKTQPDGLAIVMEASH 198 Query: 211 FCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQR 251 +CM WRGVKDMDSKMINSVMRG FL+D NLRREFLALI Q+ Sbjct: 199 YCMAWRGVKDMDSKMINSVMRGVFLKDPNLRREFLALIPQK 239