BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0031.p (1247 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003777725.1| methionine synthase I, cobalamin-binding dom... 2579 0.0 ref|YP_004754784.1| 5-methyltetrahydrofolate--homocysteine methy... 2270 0.0 ref|YP_001351839.1| B12-dependent methionine synthase [Janthinob... 2258 0.0 ref|YP_001098489.1| B12-dependent methionine synthase [Herminiim... 2231 0.0 ref|YP_546615.1| B12-dependent methionine synthase [Methylobacil... 2143 0.0 ref|YP_003052348.1| B12-dependent methionine synthase [Methylovo... 2133 0.0 ref|YP_004040900.1| methionine synthase [Methylovorus sp. MP688]... 2129 0.0 ref|YP_003675566.1| methionine synthase [Methylotenera versatili... 2091 0.0 dbj|BAG48547.1| methionine synthase [Methylophilus methylotrophus] 2075 0.0 ref|YP_003049715.1| B12-dependent methionine synthase [Methylote... 2060 0.0 >ref|YP_003777725.1| methionine synthase I, cobalamin-binding domain-containing protein [Herbaspirillum seropedicae SmR1] gb|ADJ65817.1| methionine synthase I, cobalamin-binding domain protein [Herbaspirillum seropedicae SmR1] Length = 1247 Score = 2579 bits (6684), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1246/1247 (99%), Positives = 1247/1247 (100%) Query: 1 MKPNELCQTELLLRDLMSQRILILDGAMGTMIQRYKLTEEDYRGQRFADFSVPGKDLFVK 60 MKPNELCQTELLLRDLMSQRILILDGAMGTMIQRYKLTEEDYRGQRFADFSVPGKDLFVK Sbjct: 1 MKPNELCQTELLLRDLMSQRILILDGAMGTMIQRYKLTEEDYRGQRFADFSVPGKDLFVK 60 Query: 61 GNNELLSLTQPHIIQEIHEQYLAAGADLIETNTFGATSVAQDDYHMAHLVYEMNVESARL 120 GNNELLSLTQPHIIQEIHEQYLAAGADLIETNTFGATSVAQDDYHMAHLVYEMNVESARL Sbjct: 61 GNNELLSLTQPHIIQEIHEQYLAAGADLIETNTFGATSVAQDDYHMAHLVYEMNVESARL 120 Query: 121 ARAACDKYATPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVAAYLEQTRALVE 180 ARAACDKYATPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVAAYLEQTRALVE Sbjct: 121 ARAACDKYATPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVAAYLEQTRALVE 180 Query: 181 GGADVLLVETIFDTLNCKAALFAIDTFFEESGKRLPIMISGTVTDASGRILSGQTVTAFW 240 GGADVLLVETIFDTLNCKAALFAIDTFFEESG+RLPIMISGTVTDASGRILSGQTVTAFW Sbjct: 181 GGADVLLVETIFDTLNCKAALFAIDTFFEESGQRLPIMISGTVTDASGRILSGQTVTAFW 240 Query: 241 NSIRHARPLTVGLNCALGAALMRPYAEELSKIADTFVCIYPNAGLPNPMSDTGFDETPDV 300 NSIRHARPLTVGLNCALGAALMRPYAEELSKIADTFVCIYPNAGLPNPMSDTGFDETPDV Sbjct: 241 NSIRHARPLTVGLNCALGAALMRPYAEELSKIADTFVCIYPNAGLPNPMSDTGFDETPDV 300 Query: 301 TSALLKEFAESGFVNVAGGCCGTTPPHIKAIAETVAKIAPRKVPEPTHEMRLSGLEPFTI 360 TSALLKEFAESGFVNVAGGCCGTTPPHIKAIAETVAKIAPRKVPEPTHEMRLSGLEPFTI Sbjct: 301 TSALLKEFAESGFVNVAGGCCGTTPPHIKAIAETVAKIAPRKVPEPTHEMRLSGLEPFTI 360 Query: 361 NDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQIIDINMDEAMLDSV 420 NDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQIIDINMDEAMLDSV Sbjct: 361 NDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQIIDINMDEAMLDSV 420 Query: 421 AAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKSIVNSISMKEGEEKFLREA 480 AAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKSIVNSISMKEGEEKFLREA Sbjct: 421 AAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKSIVNSISMKEGEEKFLREA 480 Query: 481 KLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLLVDKLDFPPEDIIFDPNIFAVAT 540 KLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLLVDKLDFPPEDIIFDPNIFAVAT Sbjct: 481 KLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLLVDKLDFPPEDIIFDPNIFAVAT 540 Query: 541 GIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKA 600 GIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKA Sbjct: 541 GIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKA 600 Query: 601 GMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDATERMIEYAATLKAGDKKEEATLE 660 GMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDATERMIEYAATLKAGDKKEEATLE Sbjct: 601 GMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDATERMIEYAATLKAGDKKEEATLE 660 Query: 661 WRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIAADGGRPIHVIEGPLMDGMNVVGDLFG 720 WRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIAADGGRPIHVIEGPLMDGMNVVGDLFG Sbjct: 661 WRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIAADGGRPIHVIEGPLMDGMNVVGDLFG 720 Query: 721 QGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIATGEVAKPKGKIVIATVKGDVHDI 780 QGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIATGEVAKPKGKIVIATVKGDVHDI Sbjct: 721 QGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIATGEVAKPKGKIVIATVKGDVHDI 780 Query: 781 GKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKADIIGLSGLITPSLEEMAYVAKEM 840 GKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKADIIGLSGLITPSLEEMAYVAKEM Sbjct: 781 GKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKADIIGLSGLITPSLEEMAYVAKEM 840 Query: 841 QRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEGPVVYVPDASRAVSVAQSLLADEQKT 900 QRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEGPVVYVPDASRAVSVAQSLLADEQKT Sbjct: 841 QRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEGPVVYVPDASRAVSVAQSLLADEQKT 900 Query: 901 QYVAELNADYERIREQHASKKAAPMLSLAAARANKTKLDFAPVKPKFIGRRLFKNVDLGL 960 QYVAELNADYERIREQHASKKAAPMLSLAAARANKTKLDFAPVKPKFIGRRLFKNVDLGL Sbjct: 901 QYVAELNADYERIREQHASKKAAPMLSLAAARANKTKLDFAPVKPKFIGRRLFKNVDLGL 960 Query: 961 LANYIDWGPFFQTWDLAGPYPAILTDEVVGEAATKVFQEAQAMLKKIIDGRWLTANGVIS 1020 LANYIDWGPFFQTWDLAGPYPAILTDEVVGEAATKVFQEAQAMLKKIIDGRWLTANGVIS Sbjct: 961 LANYIDWGPFFQTWDLAGPYPAILTDEVVGEAATKVFQEAQAMLKKIIDGRWLTANGVIS 1020 Query: 1021 LLPANTVNDDDIEIYTDDSRSQVAFTYYGLRQQTEKPVVDGVARPNQCLSDFIAPKESGV 1080 LLPANTVNDDDIEIYTDDSRSQVAFTYYGLRQQTEKPVVDGVARPNQCLSDFIAPKESGV Sbjct: 1021 LLPANTVNDDDIEIYTDDSRSQVAFTYYGLRQQTEKPVVDGVARPNQCLSDFIAPKESGV 1080 Query: 1081 QDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSIMLKALADRLAEAFAEYLHERVRKDLWGY 1140 QDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSIMLKALADRLAEAFAEYLHERVRKDLWGY Sbjct: 1081 QDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSIMLKALADRLAEAFAEYLHERVRKDLWGY 1140 Query: 1141 AADENLSSTDLIKEKYLGIRPAPGYPACPEHTVKADVFRTMQCDEIGMQLTESYAMFPGA 1200 AADENLSSTDLIKEKYLGIRPAPGYPACPEHTVKADVFRTMQCDEIGMQLTESYAMFPGA Sbjct: 1141 AADENLSSTDLIKEKYLGIRPAPGYPACPEHTVKADVFRTMQCDEIGMQLTESYAMFPGA 1200 Query: 1201 SVSGFYFAHPQSKYFVVGKIGEDQVVDMAERRHVPKEELERWLAPNL 1247 SVSGFYFAHPQSKYFVVGKIGEDQVVDMAERRHVPKEELERWLAPNL Sbjct: 1201 SVSGFYFAHPQSKYFVVGKIGEDQVVDMAERRHVPKEELERWLAPNL 1247 >ref|YP_004754784.1| 5-methyltetrahydrofolate--homocysteine methyltransferase [Collimonas fungivorans Ter331] gb|AEK63961.1| 5-methyltetrahydrofolate--homocysteine methyltransferase [Collimonas fungivorans Ter331] Length = 1253 Score = 2270 bits (5882), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1080/1242 (86%), Positives = 1164/1242 (93%), Gaps = 3/1242 (0%) Query: 9 TELLLRDLMSQRILILDGAMGTMIQRYKLTEEDYRGQ---RFADFSVPGKDLFVKGNNEL 65 TE LR+L++QRILILDGAMGTMIQ+YKLTEEDYRG RF DF+ PG++LFVKGNNEL Sbjct: 12 TETRLRELLAQRILILDGAMGTMIQQYKLTEEDYRGGPKGRFIDFTGPGRELFVKGNNEL 71 Query: 66 LSLTQPHIIQEIHEQYLAAGADLIETNTFGATSVAQDDYHMAHLVYEMNVESARLARAAC 125 LSLTQPHII IHE+YLAAGADLIE+NTFGAT+VAQDDYHMAHL YEMNV SARLARAAC Sbjct: 72 LSLTQPHIISAIHEEYLAAGADLIESNTFGATTVAQDDYHMAHLAYEMNVASARLARAAC 131 Query: 126 DKYATPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVAAYLEQTRALVEGGADV 185 DKY+TPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVA+YLEQTR LVEGGADV Sbjct: 132 DKYSTPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVASYLEQTRGLVEGGADV 191 Query: 186 LLVETIFDTLNCKAALFAIDTFFEESGKRLPIMISGTVTDASGRILSGQTVTAFWNSIRH 245 LLVETIFDTLNCKAALFAIDTFFEESG RLPIMISGTVTDASGRILSGQTV AFWNSIRH Sbjct: 192 LLVETIFDTLNCKAALFAIDTFFEESGLRLPIMISGTVTDASGRILSGQTVPAFWNSIRH 251 Query: 246 ARPLTVGLNCALGAALMRPYAEELSKIADTFVCIYPNAGLPNPMSDTGFDETPDVTSALL 305 A+PLTVGLNCALGAALMRPYAEELSKIADTFVCIYPNAGLPNPMSDTGFDETPDVTS+LL Sbjct: 252 AKPLTVGLNCALGAALMRPYAEELSKIADTFVCIYPNAGLPNPMSDTGFDETPDVTSSLL 311 Query: 306 KEFAESGFVNVAGGCCGTTPPHIKAIAETVAKIAPRKVPEPTHEMRLSGLEPFTINDDSL 365 K+FAESGFVN+AGGCCGTTPPHIKAIA+TVA+I PR VPE THEMRLSGLEPFTI+D SL Sbjct: 312 KDFAESGFVNIAGGCCGTTPPHIKAIADTVARIPPRAVPETTHEMRLSGLEPFTIDDSSL 371 Query: 366 YVNVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQIIDINMDEAMLDSVAAMTR 425 +VNVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQ+IDINMDEAMLDS+AAM R Sbjct: 372 FVNVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQVIDINMDEAMLDSMAAMQR 431 Query: 426 FLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKSIVNSISMKEGEEKFLREAKLCRR 485 FLNLIASEPDIARVPIMIDSSKW VIEAGLKCVQGK+IVNSISMKEGE +FLR+AKLCRR Sbjct: 432 FLNLIASEPDIARVPIMIDSSKWTVIEAGLKCVQGKAIVNSISMKEGEPEFLRQAKLCRR 491 Query: 486 YGAAVIVMAFDEVGQADTFARKIEICERAYRLLVDKLDFPPEDIIFDPNIFAVATGIEEH 545 YGAAVIVMAFDE GQADTF RKIEICERAYRLLVD++ FPPEDIIFDPNIFA+ATGIEEH Sbjct: 492 YGAAVIVMAFDEKGQADTFERKIEICERAYRLLVDQIGFPPEDIIFDPNIFAIATGIEEH 551 Query: 546 NNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKAGMTMG 605 NNYAVDFI ATRWI +NLP+AKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKAGMTMG Sbjct: 552 NNYAVDFINATRWIRENLPHAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKAGMTMG 611 Query: 606 IVNAGMIGVYDDLPAELRERVEDVVLNRREDATERMIEYAATLKAGDKKEEATLEWRNLP 665 IVNAGM+GVYD+LPAELRERVEDVVLNRREDATERMIE A+TLKAGDKKEEATLEWR+ Sbjct: 612 IVNAGMMGVYDNLPAELRERVEDVVLNRREDATERMIEIASTLKAGDKKEEATLEWRSGT 671 Query: 666 VAKRLSHALVHGITQWIVEDTEEVRQQIAADGGRPIHVIEGPLMDGMNVVGDLFGQGKMF 725 V +RL+HALV GITQWIVEDTEE RQ++ +GGRPIHVIEGPLMDGMN+VGDLFGQGKMF Sbjct: 672 VQQRLAHALVQGITQWIVEDTEEARQELLNNGGRPIHVIEGPLMDGMNIVGDLFGQGKMF 731 Query: 726 LPQVVKSARVMKQAVAHLIPFIEEEKRQLEIATGEVAKPKGKIVIATVKGDVHDIGKNIV 785 LPQVVKSARVMKQAVAHLIP+IEEEKR E TG AKPKGKIVIATVKGDVHDIGKNIV Sbjct: 732 LPQVVKSARVMKQAVAHLIPYIEEEKRLHEELTGIAAKPKGKIVIATVKGDVHDIGKNIV 791 Query: 786 TVVLQCNNFEVVNMGVMVPCAEILAKAKEEKADIIGLSGLITPSLEEMAYVAKEMQRDPY 845 +VVLQCNNFEVVNMGVMVPC+EILA AK E ADIIGLSGLITPSLEEMA+VAKEMQRDPY Sbjct: 792 SVVLQCNNFEVVNMGVMVPCSEILAMAKAENADIIGLSGLITPSLEEMAHVAKEMQRDPY 851 Query: 846 FAGLKMPLMIGGATTSRAHTAVKIAPNYEGPVVYVPDASRAVSVAQSLLADEQKTQYVAE 905 F +KMPL+IGGATTSRAHTAVKIAPNYEGPVVYVPDASR+VSVAQSLL EQ+ QY+ E Sbjct: 852 FRSVKMPLLIGGATTSRAHTAVKIAPNYEGPVVYVPDASRSVSVAQSLLTPEQRDQYIDE 911 Query: 906 LNADYERIREQHASKKAAPMLSLAAARANKTKLDFAPVKPKFIGRRLFKNVDLGLLANYI 965 + DYERIREQHA+KKA P+L+LAAAR N+T+L FAPVKPKFIGRR+FKNVDLG LA YI Sbjct: 912 IAVDYERIREQHANKKAVPLLTLAAARENRTRLQFAPVKPKFIGRRVFKNVDLGTLARYI 971 Query: 966 DWGPFFQTWDLAGPYPAILTDEVVGEAATKVFQEAQAMLKKIIDGRWLTANGVISLLPAN 1025 DWGPFFQTWDLAGPYPAIL DEVVGEAA+KVF+E QA+LKK+IDGRWL ANGVI+L+PAN Sbjct: 972 DWGPFFQTWDLAGPYPAILKDEVVGEAASKVFEEGQALLKKLIDGRWLIANGVIALMPAN 1031 Query: 1026 TVNDDDIEIYTDDSRSQVAFTYYGLRQQTEKPVVDGVARPNQCLSDFIAPKESGVQDYIG 1085 TVNDDDIEIYTD +R +VAFTYYGLRQQT KPV+DGV RPNQCLSDFIAPK SG+ DYIG Sbjct: 1032 TVNDDDIEIYTDHTREKVAFTYYGLRQQTVKPVIDGVPRPNQCLSDFIAPKSSGIADYIG 1091 Query: 1086 MFAVTAGLGIEKYEKRFEDAHDDYSSIMLKALADRLAEAFAEYLHERVRKDLWGYAADEN 1145 +FAVT+G+GIEKYEKRFEDAHDDYSSIMLK+LADRLAEAFAEY+HERVRKDLWGY DE+ Sbjct: 1092 LFAVTSGIGIEKYEKRFEDAHDDYSSIMLKSLADRLAEAFAEYMHERVRKDLWGYVPDES 1151 Query: 1146 LSSTDLIKEKYLGIRPAPGYPACPEHTVKADVFRTMQCDEIGMQLTESYAMFPGASVSGF 1205 LS+ LIKE Y GIRPAPGYPACPEHTVKAD+F+ +QC+EIGMQLTES+AMFPGA+VSGF Sbjct: 1152 LSNEALIKESYSGIRPAPGYPACPEHTVKADMFQLLQCEEIGMQLTESFAMFPGAAVSGF 1211 Query: 1206 YFAHPQSKYFVVGKIGEDQVVDMAERRHVPKEELERWLAPNL 1247 YFAHP+SKYFVVGKIG+DQV DMA RR K+++ERWLAPNL Sbjct: 1212 YFAHPESKYFVVGKIGDDQVSDMAARRGAGKDDVERWLAPNL 1253 >ref|YP_001351839.1| B12-dependent methionine synthase [Janthinobacterium sp. Marseille] gb|ABR88494.1| 5-methyltetrahydrofolate--homocysteine methyltransferase [Janthinobacterium sp. Marseille] Length = 1252 Score = 2258 bits (5852), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1079/1251 (86%), Positives = 1167/1251 (93%), Gaps = 4/1251 (0%) Query: 1 MKPNELCQTELLLRDLMSQRILILDGAMGTMIQRYKLTEEDYRGQRFADFSVPGKDLFVK 60 MK + LC TE+LLRDLM++RILILDGAMGTMIQ+YKLTEEDYRG RFADF+VPGK++FVK Sbjct: 1 MKRDALCPTEVLLRDLMARRILILDGAMGTMIQQYKLTEEDYRGTRFADFAVPGKEIFVK 60 Query: 61 GNNELLSLTQPHIIQEIHEQYLAAGADLIETNTFGATSVAQDDYHMAHLVYEMNVESARL 120 GNNELLSLT+P +I +IHEQYLAAGADLIE+NTFGAT+VAQDDYHM HL YEMNV SARL Sbjct: 61 GNNELLSLTRPDVISQIHEQYLAAGADLIESNTFGATTVAQDDYHMGHLAYEMNVASARL 120 Query: 121 ARAACDKYATPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVAAYLEQTRALVE 180 ARAACDKY+TPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVAAYL+QTR LVE Sbjct: 121 ARAACDKYSTPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVAAYLDQTRGLVE 180 Query: 181 GGADVLLVETIFDTLNCKAALFAIDTFFEESGKRLPIMISGTVTDASGRILSGQTVTAFW 240 GGADVLLVETIFDTLNCKAALFAID FFEESGKR PIMISGTVTDASGRILSGQTV AFW Sbjct: 181 GGADVLLVETIFDTLNCKAALFAIDQFFEESGKRFPIMISGTVTDASGRILSGQTVPAFW 240 Query: 241 NSIRHARPLTVGLNCALGAALMRPYAEELSKIADTFVCIYPNAGLPNPMSDTGFDETPDV 300 +SIRHARPLTVGLNCALGAALMRPYAEELSKIADT+VCIYPNAGLPNPMSDTGFDETPDV Sbjct: 241 HSIRHARPLTVGLNCALGAALMRPYAEELSKIADTYVCIYPNAGLPNPMSDTGFDETPDV 300 Query: 301 TSALLKEFAESGFVNVAGGCCGTTPPHIKAIAETVAKIAPRKVPEPTHEMRLSGLEPFTI 360 TS+LLK+FAESGFVNVAGGCCGTTP HIKAIAETV IAPR +P ++LSGLEPF I Sbjct: 301 TSSLLKDFAESGFVNVAGGCCGTTPDHIKAIAETVKTIAPRVIPTVEPTLKLSGLEPFII 360 Query: 361 NDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQIIDINMDEAMLDSV 420 +D SL+VNVGERTNVTGSKAFARLI+NEQYDEALAVARQQVENGAQIIDINMDEAMLDS Sbjct: 361 DDQSLFVNVGERTNVTGSKAFARLIINEQYDEALAVARQQVENGAQIIDINMDEAMLDSQ 420 Query: 421 AAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKSIVNSISMKEGEEKFLREA 480 AAM+RFLNL+ASEPDIARVPIMIDSSKW VIEAGLKCVQGK+IVNSISMKEGEEKFL EA Sbjct: 421 AAMSRFLNLVASEPDIARVPIMIDSSKWSVIEAGLKCVQGKAIVNSISMKEGEEKFLHEA 480 Query: 481 KLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLLVDKLDFPPEDIIFDPNIFAVAT 540 KLCRRYGAAVIVMAFDE GQADTF RKIEICERAY LLV+++ FPPEDIIFDPNIFA+AT Sbjct: 481 KLCRRYGAAVIVMAFDEKGQADTFERKIEICERAYWLLVNEVAFPPEDIIFDPNIFAIAT 540 Query: 541 GIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKA 600 GIEEHNNYAVDFI + RWI +NLP+AKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKA Sbjct: 541 GIEEHNNYAVDFINSVRWIKENLPHAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKA 600 Query: 601 GMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDATERMIEYAATLKAGDKKEEATLE 660 GMTMGIVNAGM+GVYD+LP ELRERVEDVVLNRREDATERMIE A+TLKAGDKKEEATLE Sbjct: 601 GMTMGIVNAGMVGVYDNLPEELRERVEDVVLNRREDATERMIEIASTLKAGDKKEEATLE 660 Query: 661 WRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIAADGGRPIHVIEGPLMDGMNVVGDLFG 720 WR+ V +RL+HALV GITQWIVEDTEE RQ++ +GGRPIHVIEGPLMDGMN+VGDLFG Sbjct: 661 WRSGTVQQRLAHALVQGITQWIVEDTEEARQELLGNGGRPIHVIEGPLMDGMNIVGDLFG 720 Query: 721 QGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIATGEVAKPKGKIVIATVKGDVHDI 780 QGKMFLPQVVKSARVMKQAVAHLIPFIEEEKR L+ TG V+KPKGKIVIATVKGDVHDI Sbjct: 721 QGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRLLQEQTGIVSKPKGKIVIATVKGDVHDI 780 Query: 781 GKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKADIIGLSGLITPSLEEMAYVAKEM 840 GKNIV+VVLQCNNFEVVNMGVMVPC+EILAKAKEE ADIIGLSGLITPSLEEMAYVAKEM Sbjct: 781 GKNIVSVVLQCNNFEVVNMGVMVPCSEILAKAKEENADIIGLSGLITPSLEEMAYVAKEM 840 Query: 841 QRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEGPVVYVPDASRAVSVAQSLLADEQKT 900 QRD YF GLK PL+IGGATTSRAHTAVKIA NY+GPVVYVPDASR+VSVAQSLL EQ+ Sbjct: 841 QRDEYFRGLKTPLLIGGATTSRAHTAVKIAHNYDGPVVYVPDASRSVSVAQSLLTPEQRD 900 Query: 901 QYVAELNADYERIREQHASKKAAPMLSLAAARANKTKLDF----APVKPKFIGRRLFKNV 956 Y+AE+ ADYERIREQHA+KKA PML+LA ARANK KL+F APVKPKFIGRR+FKNV Sbjct: 901 AYIAEIAADYERIREQHANKKAVPMLTLAEARANKMKLEFTGKYAPVKPKFIGRRVFKNV 960 Query: 957 DLGLLANYIDWGPFFQTWDLAGPYPAILTDEVVGEAATKVFQEAQAMLKKIIDGRWLTAN 1016 DL +A YIDWGPFFQTWDLAGPYPAIL DEVVGEAATKVF E QA+LKK+I+GRWL AN Sbjct: 961 DLATIAQYIDWGPFFQTWDLAGPYPAILKDEVVGEAATKVFAEGQALLKKVIEGRWLQAN 1020 Query: 1017 GVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLRQQTEKPVVDGVARPNQCLSDFIAPK 1076 GVI+LLPANTVNDDDIEIYTD++RS+VAFTYYG+RQQT KPV+DGVARPNQCL+DFIAPK Sbjct: 1021 GVIALLPANTVNDDDIEIYTDETRSKVAFTYYGVRQQTVKPVIDGVARPNQCLTDFIAPK 1080 Query: 1077 ESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSIMLKALADRLAEAFAEYLHERVRKD 1136 SGV DYIG+FAVTAGLGIEKYEKRFEDAHDDYSSIMLK+LADRLAEAFAE+LHERVRKD Sbjct: 1081 SSGVADYIGLFAVTAGLGIEKYEKRFEDAHDDYSSIMLKSLADRLAEAFAEHLHERVRKD 1140 Query: 1137 LWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEHTVKADVFRTMQCDEIGMQLTESYAM 1196 LWGYAADE L++ LIKE+Y GIRPAPGYPACPEHTVK ++F+T+Q +EIGM LT+SYAM Sbjct: 1141 LWGYAADEKLTNEALIKEEYSGIRPAPGYPACPEHTVKKEMFQTLQAEEIGMMLTDSYAM 1200 Query: 1197 FPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAERRHVPKEELERWLAPNL 1247 FPGA+VSGFYFAHP++KYFVVGKIG+DQVVDMAERR KE++ERWLAPNL Sbjct: 1201 FPGAAVSGFYFAHPEAKYFVVGKIGDDQVVDMAERRGATKEDVERWLAPNL 1251 >ref|YP_001098489.1| B12-dependent methionine synthase [Herminiimonas arsenicoxydans] emb|CAL60360.1| Methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase) (Methionine synthase, vitamin-B12 dependent) (MS) [Herminiimonas arsenicoxydans] Length = 1252 Score = 2231 bits (5780), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1064/1251 (85%), Positives = 1160/1251 (92%), Gaps = 4/1251 (0%) Query: 1 MKPNELCQTELLLRDLMSQRILILDGAMGTMIQRYKLTEEDYRGQRFADFSVPGKDLFVK 60 MK + + TE LLRDLM++RILILDGAMGTMIQ+YKLTEEDYRG RFADF+VPGK++FVK Sbjct: 1 MKRDAISPTETLLRDLMARRILILDGAMGTMIQQYKLTEEDYRGTRFADFAVPGKEVFVK 60 Query: 61 GNNELLSLTQPHIIQEIHEQYLAAGADLIETNTFGATSVAQDDYHMAHLVYEMNVESARL 120 GNNELLSLTQPH+I EIHE+YLAAGADLIE+NTFGAT+VAQDDYHM HL YEMNV SARL Sbjct: 61 GNNELLSLTQPHVISEIHEKYLAAGADLIESNTFGATTVAQDDYHMGHLAYEMNVASARL 120 Query: 121 ARAACDKYATPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVAAYLEQTRALVE 180 ARAACDKY+TPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVA+YLEQTR LVE Sbjct: 121 ARAACDKYSTPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVASYLEQTRGLVE 180 Query: 181 GGADVLLVETIFDTLNCKAALFAIDTFFEESGKRLPIMISGTVTDASGRILSGQTVTAFW 240 GGADVLLVETIFDTLNCKAALFAID FFEESG+RLPIMISGTVTDASGRILSGQTV AFW Sbjct: 181 GGADVLLVETIFDTLNCKAALFAIDQFFEESGQRLPIMISGTVTDASGRILSGQTVPAFW 240 Query: 241 NSIRHARPLTVGLNCALGAALMRPYAEELSKIADTFVCIYPNAGLPNPMSDTGFDETPDV 300 +SIRHARPLTVGLNCALGAALMRPYAEELSKIADTFVCIYPNAGLPNPMSDTGFDETPDV Sbjct: 241 HSIRHARPLTVGLNCALGAALMRPYAEELSKIADTFVCIYPNAGLPNPMSDTGFDETPDV 300 Query: 301 TSALLKEFAESGFVNVAGGCCGTTPPHIKAIAETVAKIAPRKVPEPTHEMRLSGLEPFTI 360 TS+LLK+FAESGFVN+AGGCCGTTP HIKAIA+TVA IAPR VP M+LSGLEPF I Sbjct: 301 TSSLLKDFAESGFVNIAGGCCGTTPDHIKAIADTVANIAPRIVPTIEPTMKLSGLEPFII 360 Query: 361 NDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQIIDINMDEAMLDSV 420 +D+SL+VNVGERTNVTGSKAFARLI+NE+YDEAL VARQQVENGAQIIDINMDEAMLDS Sbjct: 361 DDNSLFVNVGERTNVTGSKAFARLIINEKYDEALTVARQQVENGAQIIDINMDEAMLDSE 420 Query: 421 AAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKSIVNSISMKEGEEKFLREA 480 AAMTRFLN +ASEPDIARVPIMIDSSKW VIEAGLKCVQGK+IVNSISMKEGEEKFL +A Sbjct: 421 AAMTRFLNSVASEPDIARVPIMIDSSKWSVIEAGLKCVQGKAIVNSISMKEGEEKFLHDA 480 Query: 481 KLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLLVDKLDFPPEDIIFDPNIFAVAT 540 KLCRRYGAAVIVMAFDE GQADTF RKIEICERAY LLV+++DFPPEDIIFDPNIFA+AT Sbjct: 481 KLCRRYGAAVIVMAFDEKGQADTFERKIEICERAYWLLVNEVDFPPEDIIFDPNIFAIAT 540 Query: 541 GIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKA 600 GIEEHNNYAVDFI + RWI +NLP+AKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKA Sbjct: 541 GIEEHNNYAVDFINSVRWIKENLPHAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKA 600 Query: 601 GMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDATERMIEYAATLKAGDKKEEATLE 660 GMTMGIVNAGM+GVYD+LPAEL+E VEDVVLNRREDATERMIE AATLKAGDKKEEATLE Sbjct: 601 GMTMGIVNAGMVGVYDNLPAELKECVEDVVLNRREDATERMIEIAATLKAGDKKEEATLE 660 Query: 661 WRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIAADGGRPIHVIEGPLMDGMNVVGDLFG 720 WR+ V +RL+HALV GITQWIVEDTEE RQ++ +GGRPIHVIEGPLMDGMN+VGDLFG Sbjct: 661 WRSGTVQQRLAHALVQGITQWIVEDTEEARQELLKNGGRPIHVIEGPLMDGMNIVGDLFG 720 Query: 721 QGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIATGEVAKPKGKIVIATVKGDVHDI 780 QGKMFLPQVVKSARVMKQAVAHLIPFIEEEKR L+ TG V+KPKGKIVIATVKGDVHDI Sbjct: 721 QGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRLLQEQTGIVSKPKGKIVIATVKGDVHDI 780 Query: 781 GKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKADIIGLSGLITPSLEEMAYVAKEM 840 GKNIV+VVLQCNNFEVVNMGVMVPC+EILA+AK E ADIIGLSGLITPSLEEMAYVAKEM Sbjct: 781 GKNIVSVVLQCNNFEVVNMGVMVPCSEILARAKAENADIIGLSGLITPSLEEMAYVAKEM 840 Query: 841 QRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEGPVVYVPDASRAVSVAQSLLADEQKT 900 QRD YF GLK PL+IGGATTSRAHTAVKIA NY+GPVVYVPDASR+VSVAQSLL E + Sbjct: 841 QRDEYFRGLKTPLLIGGATTSRAHTAVKIAHNYDGPVVYVPDASRSVSVAQSLLTPESRD 900 Query: 901 QYVAELNADYERIREQHASKKAAPMLSLAAARANKTKLDF----APVKPKFIGRRLFKNV 956 QY+A++ DYERIR QHA+KK PMLSL ARANK +++F APVKPKFIGRR+FKNV Sbjct: 901 QYIADIATDYERIRVQHANKKTLPMLSLEQARANKMQVEFTGKYAPVKPKFIGRRVFKNV 960 Query: 957 DLGLLANYIDWGPFFQTWDLAGPYPAILTDEVVGEAATKVFQEAQAMLKKIIDGRWLTAN 1016 DL +A YIDWGPFFQTWDLAGPYPAILTDEVVG+AATKVF E QA+LKKII+GRWLTAN Sbjct: 961 DLATIAQYIDWGPFFQTWDLAGPYPAILTDEVVGDAATKVFAEGQALLKKIIEGRWLTAN 1020 Query: 1017 GVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLRQQTEKPVVDGVARPNQCLSDFIAPK 1076 GVI+LLPANTVNDDDIE+YTD++R+QVAFTYYG+RQQT KP++DGV RPNQCL+DFIAPK Sbjct: 1021 GVIALLPANTVNDDDIEVYTDETRTQVAFTYYGVRQQTVKPIIDGVQRPNQCLADFIAPK 1080 Query: 1077 ESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSIMLKALADRLAEAFAEYLHERVRKD 1136 SG+ DYIG+FAVTAGLGIEKYEKRFEDA+DDYSSIMLK+LADRLAEAFAE LHERVR D Sbjct: 1081 SSGIADYIGLFAVTAGLGIEKYEKRFEDAYDDYSSIMLKSLADRLAEAFAEQLHERVRTD 1140 Query: 1137 LWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEHTVKADVFRTMQCDEIGMQLTESYAM 1196 LWGY DE LS+ +IKE+YLGIRPAPGYPACPEHTVKA++F+T+Q +EIGM LT+S+AM Sbjct: 1141 LWGYVPDEALSNEAMIKEEYLGIRPAPGYPACPEHTVKAEMFKTLQAEEIGMMLTDSFAM 1200 Query: 1197 FPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAERRHVPKEELERWLAPNL 1247 FPGA+VSGFYFAHP++KYFVVGKIGEDQV DM RR V +E++ERWLAPNL Sbjct: 1201 FPGAAVSGFYFAHPEAKYFVVGKIGEDQVKDMVLRRGVSQEDIERWLAPNL 1251 >ref|YP_546615.1| B12-dependent methionine synthase [Methylobacillus flagellatus KT] gb|ABE50774.1| methionine synthase (B12-dependent) [Methylobacillus flagellatus KT] Length = 1262 Score = 2143 bits (5552), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1026/1261 (81%), Positives = 1145/1261 (90%), Gaps = 14/1261 (1%) Query: 1 MKPNELCQTELLLRDLMSQRILILDGAMGTMIQRYKLTEEDYRGQ---RFADFSVPG--K 55 MK E+ TE+LLR+++S+RI+ILDGAMGTMIQ+YKLTEEDYRG RFADF+ P + Sbjct: 1 MKHYEMSPTEVLLREILSKRIMILDGAMGTMIQQYKLTEEDYRGGPQGRFADFAAPEGER 60 Query: 56 DLFVKGNNELLSLTQPHIIQEIHEQYLAAGADLIETNTFGATSVAQDDYHMAHLVYEMNV 115 +LFVKGNNELL+ TQP IIQEIHEQYLAAGAD+IETNTFGATSVAQ+DY MAHL YEMNV Sbjct: 61 ELFVKGNNELLTFTQPQIIQEIHEQYLAAGADIIETNTFGATSVAQEDYFMAHLAYEMNV 120 Query: 116 ESARLARAACDKYATPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVAAYLEQT 175 E+ARLARAACDK++T DKPRFVAGALGPTPKTASISPDVNDPAARN+TFDQLVAAY EQ Sbjct: 121 EAARLARAACDKFSTSDKPRFVAGALGPTPKTASISPDVNDPAARNITFDQLVAAYHEQA 180 Query: 176 RALVEGGADVLLVETIFDTLNCKAALFAIDTFFEESGKRLPIMISGTVTDASGRILSGQT 235 R LV+GGAD+L+VET+FDTLNCKAALFAID +FEE+GKRLPIMISGTVTDASGRILSGQT Sbjct: 181 RGLVDGGADILMVETVFDTLNCKAALFAIDQYFEETGKRLPIMISGTVTDASGRILSGQT 240 Query: 236 VTAFWNSIRHARPLTVGLNCALGAALMRPYAEELSKIADTFVCIYPNAGLPNPMSDTGFD 295 V AFW SIRHARPLT+GLNCALGAALMRPYAEELS+IADTFVCIYPNAGLPNPMSDTGFD Sbjct: 241 VPAFWYSIRHARPLTIGLNCALGAALMRPYAEELSRIADTFVCIYPNAGLPNPMSDTGFD 300 Query: 296 ETPDVTSALLKEFAESGFVNVAGGCCGTTPPHIKAIAETVAKIAPRKVPEPTHEMRLSGL 355 E P+ TSALL+EFAESGFVN+AGGCCGTTP HI AIAE V I PR++P+ RL+GL Sbjct: 301 EKPEDTSALLREFAESGFVNIAGGCCGTTPSHIAAIAEAVRDIPPRRIPQIPVATRLAGL 360 Query: 356 EPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQIIDINMDEA 415 EPFTI++DSL+VNVGERTNVTGSKAFAR+ILNEQY+EALAVARQQVENGAQ+IDINMDE Sbjct: 361 EPFTIDEDSLFVNVGERTNVTGSKAFARMILNEQYEEALAVARQQVENGAQVIDINMDEG 420 Query: 416 MLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKSIVNSISMKEGEEK 475 MLD+V AMT FLNL+ASEPDIARVPIMIDSSKW VIEAGLKCVQGK IVNSISMKEGE + Sbjct: 421 MLDAVRAMTHFLNLVASEPDIARVPIMIDSSKWAVIEAGLKCVQGKCIVNSISMKEGEAE 480 Query: 476 FLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLLVDKLDFPPEDIIFDPNI 535 FLR+A LCRRYGAAVIVMAFDE GQADTF RKIEIC+RAY LLV+KL+FPPEDIIFDPNI Sbjct: 481 FLRQAALCRRYGAAVIVMAFDETGQADTFERKIEICKRAYDLLVEKLNFPPEDIIFDPNI 540 Query: 536 FAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSFRGNDPAREAIHTVFLY 595 FAVATGIEEHNNYAVDFI ATRWI +NLP+A+ISGGVSNVSFSFRGN+ AREAIHTVFLY Sbjct: 541 FAVATGIEEHNNYAVDFINATRWIKENLPHARISGGVSNVSFSFRGNEAAREAIHTVFLY 600 Query: 596 HAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDATERMIEYAATLKAGDKKE 655 HAIKAGMTMGIVNAGMIGVYDDL ELRERVEDVVLNRREDATERMIE+AATL AG KK+ Sbjct: 601 HAIKAGMTMGIVNAGMIGVYDDLDPELRERVEDVVLNRREDATERMIEFAATLAAGGKKQ 660 Query: 656 EATLEWRN-----LPVAKRLSHALVHGITQWIVEDTEEVRQQIAADGGRPIHVIEGPLMD 710 EATL+WR +PV KRL +A+VHGIT++IV+DTEE RQ++ ++GGRPIHVIEGPLMD Sbjct: 661 EATLDWRGTPENPVPVEKRLEYAMVHGITEFIVQDTEEARQKVMSEGGRPIHVIEGPLMD 720 Query: 711 GMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIATGEVAKPKGKIVI 770 GMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKR E TG VAKPKGK+VI Sbjct: 721 GMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRAEEARTGIVAKPKGKMVI 780 Query: 771 ATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKADIIGLSGLITPSL 830 ATVKGDVHDIGKNIV+VVLQCNNFEVVNMGVMVPCAEILA+AK ADIIGLSGLITPSL Sbjct: 781 ATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCAEILAQAKATGADIIGLSGLITPSL 840 Query: 831 EEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEGPVVYVPDASRAVSVA 890 EEMAYVA+EMQRDPYF G+KMPL+IGGATTSRAHTAVKIAP+Y+GPV+YVPDASR+VSV Sbjct: 841 EEMAYVAREMQRDPYFHGIKMPLLIGGATTSRAHTAVKIAPHYDGPVIYVPDASRSVSVM 900 Query: 891 QSLLADEQKTQYVAELNADYERIREQHASKKAAPMLSLAAARANKTKLD----FAPVKPK 946 QSLL EQ+ Y+AE+ DYER+R QHA+KK P+L+LA ARANK KLD FAPVKPK Sbjct: 901 QSLLTPEQRDNYIAEVQQDYERVRTQHANKKGIPLLTLAEARANKAKLDFTGRFAPVKPK 960 Query: 947 FIGRRLFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVVGEAATKVFQEAQAMLKK 1006 FIGRR+FKN+DL +A YIDWGPFFQTWDLAG YPAIL D+VVG AA+K+F E QAMLKK Sbjct: 961 FIGRRVFKNIDLATIAQYIDWGPFFQTWDLAGSYPAILQDDVVGAAASKLFAEGQAMLKK 1020 Query: 1007 IIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLRQQTEKPVVDGVARPN 1066 II+GRWLTA+GV++LLPAN+VNDDDIEIYTDD+RSQVAFTYYG+RQQT+KP+V G RPN Sbjct: 1021 IIEGRWLTASGVVALLPANSVNDDDIEIYTDDTRSQVAFTYYGMRQQTQKPIVKGEQRPN 1080 Query: 1067 QCLSDFIAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSIMLKALADRLAEAFA 1126 QCL+DFIAPKESG+ DYIGMFAVT GLGIEKYE+RFE AHDDYSSIMLK+LADRLAEAFA Sbjct: 1081 QCLADFIAPKESGIADYIGMFAVTGGLGIEKYEQRFEAAHDDYSSIMLKSLADRLAEAFA 1140 Query: 1127 EYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEHTVKADVFRTMQCDEI 1186 EY+HERVRKDLWGYA DE LS LIKE+Y GIRPAPGYPACP+HTVK D+F M+C+E+ Sbjct: 1141 EYMHERVRKDLWGYAPDEALSKEALIKEQYRGIRPAPGYPACPDHTVKPDMFNLMKCEEV 1200 Query: 1187 GMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAERRHVPKEELERWLAPN 1246 G++LT+S+AM PGA+VSGFYFAHP+++YF V KIGEDQ++DMA+RR +P+E LERWLAPN Sbjct: 1201 GIRLTDSFAMMPGAAVSGFYFAHPEARYFSVDKIGEDQLLDMAKRRGLPREYLERWLAPN 1260 Query: 1247 L 1247 L Sbjct: 1261 L 1261 >ref|YP_003052348.1| B12-dependent methionine synthase [Methylovorus glucosetrophus SIP3-4] gb|ACT51821.1| methionine synthase [Methylovorus glucosetrophus SIP3-4] Length = 1289 Score = 2133 bits (5526), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1037/1278 (81%), Positives = 1130/1278 (88%), Gaps = 37/1278 (2%) Query: 6 LCQTELLLRDLMSQRILILDGAMGTMIQRYKLTEEDYRGQ---RFADFSVPG-------- 54 + TE+ LR+L+++RILILDGAMGTMIQRYKLTEEDYRG RFADF PG Sbjct: 13 ISATEVRLRELLAERILILDGAMGTMIQRYKLTEEDYRGGPQGRFADFK-PGLAFCPNGD 71 Query: 55 ----------------KDLFVKGNNELLSLTQPHIIQEIHEQYLAAGADLIETNTFGATS 98 ++LFVKGNNELL+LTQPHIIQEIHEQYLAAGAD+IETNTFGAT+ Sbjct: 72 GCGCGQPHAAPAEGEARELFVKGNNELLTLTQPHIIQEIHEQYLAAGADIIETNTFGATT 131 Query: 99 VAQDDYHMAHLVYEMNVESARLARAACDKYATPDKPRFVAGALGPTPKTASISPDVNDPA 158 VAQ+DYHMAHL +EMNVE+A+LARAACDKY+TPDKPRFVAGALGPTPKTASISPDVNDPA Sbjct: 132 VAQEDYHMAHLAFEMNVEAAKLARAACDKYSTPDKPRFVAGALGPTPKTASISPDVNDPA 191 Query: 159 ARNVTFDQLVAAYLEQTRALVEGGADVLLVETIFDTLNCKAALFAIDTFFEESGKRLPIM 218 ARN+TFDQLV AYLEQT ALVEGGAD+LLVETIFDTLNCKAALFAID +FE+SGKRLPIM Sbjct: 192 ARNITFDQLVKAYLEQTIALVEGGADILLVETIFDTLNCKAALFAIDAYFEQSGKRLPIM 251 Query: 219 ISGTVTDASGRILSGQTVTAFWNSIRHARPLTVGLNCALGAALMRPYAEELSKIADTFVC 278 ISGTVTDASGRILSGQTV AFW+S+RHARPLT+GLNCALGAALMRPYAEELSKIADTFVC Sbjct: 252 ISGTVTDASGRILSGQTVPAFWHSVRHARPLTIGLNCALGAALMRPYAEELSKIADTFVC 311 Query: 279 IYPNAGLPNPMSDTGFDETPDVTSALLKEFAESGFVNVAGGCCGTTPPHIKAIAETVAKI 338 IYPNAGLPNPMSDTGFDE P TS+LLKEFAESGFVNVAGGCCGTTP HI+AIAETV I Sbjct: 312 IYPNAGLPNPMSDTGFDEEPQDTSSLLKEFAESGFVNVAGGCCGTTPAHIQAIAETVKNI 371 Query: 339 APRKVPEPTHEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVAR 398 APR+VP P H L+GLEPF I+D SL+VNVGERTNVTGSKAFAR+ILNEQY++AL VAR Sbjct: 372 APRQVPAPRHATLLAGLEPFIIDDSSLFVNVGERTNVTGSKAFARMILNEQYEDALQVAR 431 Query: 399 QQVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCV 458 QQVENGAQ+IDINMDE MLD+V AMT FLNL+ASEPDIARVPIMIDSSKWEVIEAGLKCV Sbjct: 432 QQVENGAQVIDINMDEGMLDAVKAMTHFLNLVASEPDIARVPIMIDSSKWEVIEAGLKCV 491 Query: 459 QGKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLL 518 QGKSIVNSISMKEGE +FLR+A+LCRRYGAAVIVMAFDE GQADT+ RKIEIC+RAY LL Sbjct: 492 QGKSIVNSISMKEGEAEFLRQARLCRRYGAAVIVMAFDEKGQADTYERKIEICKRAYDLL 551 Query: 519 VDKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFS 578 V++ FPPEDIIFDPNIFAVATGIEEHNNYAVDFI ATRWI +NLPYAKISGGVSNVSFS Sbjct: 552 VNEASFPPEDIIFDPNIFAVATGIEEHNNYAVDFINATRWIKENLPYAKISGGVSNVSFS 611 Query: 579 FRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDAT 638 FRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGM+GVYDDLPAELRERVEDVVLNRREDAT Sbjct: 612 FRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMVGVYDDLPAELRERVEDVVLNRREDAT 671 Query: 639 ERMIEYAATLKAGDKKEEATLEWRNLP-----VAKRLSHALVHGITQWIVEDTEEVRQQI 693 ERMIE+AATL AG KKE TLEWR P V KRL HA+VHGIT++IVEDTEE RQQ+ Sbjct: 672 ERMIEFAATLTAGGKKEAPTLEWRGTPEQPVSVGKRLEHAMVHGITEFIVEDTEEARQQV 731 Query: 694 AADGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQ 753 A GGRPI+VIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEK Sbjct: 732 MAAGGRPINVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKAA 791 Query: 754 LEIATGEVAKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAK 813 E TG AKPKGK+VIATVKGDVHDIGKNIV+VVLQCNNFEVVNMGVMVPC+EILA AK Sbjct: 792 EEKRTGVAAKPKGKVVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCSEILATAK 851 Query: 814 EEKADIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNY 873 E ADIIGLSGLITPSLEEMAYVAKEMQRDP+F LK+PL+IGGATTSRAHTAVKIAPNY Sbjct: 852 VENADIIGLSGLITPSLEEMAYVAKEMQRDPHFRMLKIPLLIGGATTSRAHTAVKIAPNY 911 Query: 874 EGPVVYVPDASRAVSVAQSLLADEQKTQYVAELNADYERIREQHASKKAAPMLSLAAARA 933 +GPV+YVPDASR+VSV QSLL EQ+ Y+ E+ ADY+R R QHA+KK ML+LA ARA Sbjct: 912 DGPVIYVPDASRSVSVMQSLLTPEQRESYINEVAADYDRARTQHANKKGPTMLTLAEARA 971 Query: 934 NKTKLDF----APVKPKFIGRRLFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVV 989 NK K F APVKPKFIGRR+FKN+DL +A YIDWGPFFQTWDLAG YPAILTD VV Sbjct: 972 NKVKARFDGANAPVKPKFIGRRVFKNIDLATIAEYIDWGPFFQTWDLAGFYPAILTDSVV 1031 Query: 990 GEAATKVFQEAQAMLKKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYG 1049 GEAATK+ E QAMLKKII+GRWLTANGV++LLPANTVNDDDIEIYTDD+RSQVAFT+YG Sbjct: 1032 GEAATKLLAEGQAMLKKIIEGRWLTANGVVALLPANTVNDDDIEIYTDDTRSQVAFTWYG 1091 Query: 1050 LRQQTEKPVVDGVARPNQCLSDFIAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDY 1109 +RQQT KPV+DGVARPNQCL+D+IAPK SGV DYIGMFAVT GLGI+KY +RFE+ HDDY Sbjct: 1092 MRQQTAKPVIDGVARPNQCLADYIAPKASGVADYIGMFAVTGGLGIDKYLERFENDHDDY 1151 Query: 1110 SSIMLKALADRLAEAFAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACP 1169 SSIMLK+LADRLAEAFAEYLH RVR DLWGYAADE L + LIKE+Y GIRPAPGYPACP Sbjct: 1152 SSIMLKSLADRLAEAFAEYLHARVRTDLWGYAADEQLDNDALIKEQYRGIRPAPGYPACP 1211 Query: 1170 EHTVKADVFRTMQCDEIGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMA 1229 +HTVK D+F+ MQCDEIGM LTES AM P A+VSGFY AH +KYF V KIG+DQ+ DMA Sbjct: 1212 DHTVKPDMFQVMQCDEIGMTLTESLAMMPAAAVSGFYLAHADAKYFSVDKIGQDQLKDMA 1271 Query: 1230 ERRHVPKEELERWLAPNL 1247 RR + +E LERWLAPNL Sbjct: 1272 TRRGLSEEYLERWLAPNL 1289 >ref|YP_004040900.1| methionine synthase [Methylovorus sp. MP688] gb|ADQ85664.1| methionine synthase [Methylovorus sp. MP688] Length = 1289 Score = 2129 bits (5516), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1035/1278 (80%), Positives = 1128/1278 (88%), Gaps = 37/1278 (2%) Query: 6 LCQTELLLRDLMSQRILILDGAMGTMIQRYKLTEEDYRGQ---RFADFSVPG-------- 54 + TE+ LR+L+++RILILDGAMGTMIQRYKLTEEDYRG RFADF PG Sbjct: 13 ISATEVRLRELLAERILILDGAMGTMIQRYKLTEEDYRGGPQGRFADFK-PGLAFCPNGD 71 Query: 55 ----------------KDLFVKGNNELLSLTQPHIIQEIHEQYLAAGADLIETNTFGATS 98 ++LFVKGNNELL+LTQPHIIQEIHEQYLAAGAD+IETNTFGAT+ Sbjct: 72 GCGCGQPHAAPAEGEARELFVKGNNELLTLTQPHIIQEIHEQYLAAGADIIETNTFGATT 131 Query: 99 VAQDDYHMAHLVYEMNVESARLARAACDKYATPDKPRFVAGALGPTPKTASISPDVNDPA 158 VAQ+DYHMAHL +EMNVE+A+LARAACDKY+TPDKPRFVAGALGPTPKTASISPDVNDPA Sbjct: 132 VAQEDYHMAHLAFEMNVEAAKLARAACDKYSTPDKPRFVAGALGPTPKTASISPDVNDPA 191 Query: 159 ARNVTFDQLVAAYLEQTRALVEGGADVLLVETIFDTLNCKAALFAIDTFFEESGKRLPIM 218 ARN+TFDQLV AYLEQT ALVEGGAD+LLVETIFDTLNCKAALFAID +FE+SGKRLPIM Sbjct: 192 ARNITFDQLVKAYLEQTIALVEGGADILLVETIFDTLNCKAALFAIDAYFEQSGKRLPIM 251 Query: 219 ISGTVTDASGRILSGQTVTAFWNSIRHARPLTVGLNCALGAALMRPYAEELSKIADTFVC 278 ISGTVTDASGRILSGQTV AFW+S+RHARPLT+GLNCALGAALMRPYAEELSKIADTFVC Sbjct: 252 ISGTVTDASGRILSGQTVPAFWHSVRHARPLTIGLNCALGAALMRPYAEELSKIADTFVC 311 Query: 279 IYPNAGLPNPMSDTGFDETPDVTSALLKEFAESGFVNVAGGCCGTTPPHIKAIAETVAKI 338 IYPNAGLPNPMSDTGFDE P TS+LLKEFAESGFVNVAGGCCGTTP HI+AIAETV I Sbjct: 312 IYPNAGLPNPMSDTGFDEEPQDTSSLLKEFAESGFVNVAGGCCGTTPAHIQAIAETVKNI 371 Query: 339 APRKVPEPTHEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVAR 398 APR+VP P H L+GLEPF I+D SL+VNVGERTNVTGSKAFAR+ILNEQY++AL VAR Sbjct: 372 APRQVPAPRHATLLAGLEPFIIDDSSLFVNVGERTNVTGSKAFARMILNEQYEDALQVAR 431 Query: 399 QQVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCV 458 QQVENGAQ+IDINMDE MLD+V AMT FLNL+ASEPDIARVPIMIDSSKWEVIEAGLKCV Sbjct: 432 QQVENGAQVIDINMDEGMLDAVKAMTHFLNLVASEPDIARVPIMIDSSKWEVIEAGLKCV 491 Query: 459 QGKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLL 518 QGKSIVNSISMKEGE +FLR+A+LCRRYGAAVIVMAFDE GQADT+ RKIEIC+RAY LL Sbjct: 492 QGKSIVNSISMKEGEAEFLRQARLCRRYGAAVIVMAFDEKGQADTYERKIEICKRAYDLL 551 Query: 519 VDKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFS 578 V + FPPEDIIFDPNIFAVATGIEEHNNYAVDFI ATRWI +NLPYAKISGGVSNVSFS Sbjct: 552 VKEASFPPEDIIFDPNIFAVATGIEEHNNYAVDFINATRWIKENLPYAKISGGVSNVSFS 611 Query: 579 FRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDAT 638 FRGND AREAIHTVFLYHAIKAGMTMGIVNAGM+GVYDDLPAELRERVEDVVLNRREDAT Sbjct: 612 FRGNDSAREAIHTVFLYHAIKAGMTMGIVNAGMVGVYDDLPAELRERVEDVVLNRREDAT 671 Query: 639 ERMIEYAATLKAGDKKEEATLEWRNLP-----VAKRLSHALVHGITQWIVEDTEEVRQQI 693 ERMIE+AATL AG KKE TLEWR P V KRL HA+VHGIT++IVEDTEE RQQ+ Sbjct: 672 ERMIEFAATLTAGGKKEAPTLEWRGTPEQPVSVGKRLEHAMVHGITEFIVEDTEEARQQV 731 Query: 694 AADGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQ 753 A GGRPI+VIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEK Sbjct: 732 MAAGGRPINVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKAA 791 Query: 754 LEIATGEVAKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAK 813 E TG AKPKGK+VIATVKGDVHDIGKNIV+VVLQCNNFEVVNMGVMVPC+EILA AK Sbjct: 792 EEKRTGVAAKPKGKVVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCSEILATAK 851 Query: 814 EEKADIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNY 873 E ADIIGLSGLITPSLEEMAYVAKEMQRDP+F LK+PL+IGGATTSRAHTAVKIAPNY Sbjct: 852 VENADIIGLSGLITPSLEEMAYVAKEMQRDPHFRMLKIPLLIGGATTSRAHTAVKIAPNY 911 Query: 874 EGPVVYVPDASRAVSVAQSLLADEQKTQYVAELNADYERIREQHASKKAAPMLSLAAARA 933 +GPV+YVPDASR+VSV QSLL EQ+ Y+ E+ ADY+R R QHA+KK ML+LA ARA Sbjct: 912 DGPVIYVPDASRSVSVMQSLLTPEQRESYINEVAADYDRARTQHANKKGPTMLTLAEARA 971 Query: 934 NKTKLDF----APVKPKFIGRRLFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVV 989 NK K F APVKPKFIGRR+FKN+DL +A YIDWGPFFQTWDLAG YPAILTD VV Sbjct: 972 NKVKARFDGANAPVKPKFIGRRVFKNIDLATIAEYIDWGPFFQTWDLAGFYPAILTDSVV 1031 Query: 990 GEAATKVFQEAQAMLKKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYG 1049 GEAATK+ E QAMLKKII+GRWLTANG+++LLPANTVNDDDIEIYTDD+RSQVAFT+YG Sbjct: 1032 GEAATKLLAEGQAMLKKIIEGRWLTANGIVALLPANTVNDDDIEIYTDDTRSQVAFTWYG 1091 Query: 1050 LRQQTEKPVVDGVARPNQCLSDFIAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDY 1109 +RQQT KPV+DGVARPNQCL+D+IAPK SGV DYIGMFAVT GLGI+KY +RFE+ HDDY Sbjct: 1092 MRQQTAKPVIDGVARPNQCLADYIAPKASGVADYIGMFAVTGGLGIDKYLERFENDHDDY 1151 Query: 1110 SSIMLKALADRLAEAFAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACP 1169 SSIMLK+LADRLAEAFAEYLH RVR DLWGYAADE L + LIKE+Y GIRPAPGYPACP Sbjct: 1152 SSIMLKSLADRLAEAFAEYLHARVRTDLWGYAADEQLDNDALIKEQYRGIRPAPGYPACP 1211 Query: 1170 EHTVKADVFRTMQCDEIGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMA 1229 +HTVK D+F+ MQCDEIGM LTES AM P A+VSGFY AH +KYF V KIG+DQ+ DMA Sbjct: 1212 DHTVKPDMFQVMQCDEIGMTLTESLAMMPAAAVSGFYLAHADAKYFSVDKIGQDQLKDMA 1271 Query: 1230 ERRHVPKEELERWLAPNL 1247 RR + +E LERWLAPNL Sbjct: 1272 TRRGLSEEYLERWLAPNL 1289 >ref|YP_003675566.1| methionine synthase [Methylotenera versatilis 301] gb|ADI30989.1| methionine synthase [Methylotenera versatilis 301] Length = 1265 Score = 2091 bits (5418), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1003/1260 (79%), Positives = 1112/1260 (88%), Gaps = 20/1260 (1%) Query: 5 ELCQTELLLRDLMSQRILILDGAMGTMIQRYKLTEEDYRGQRFADFSVPG--KDLFVKGN 62 E TE LR L+ QRILILDGAMGTMIQ+YKLTE DYRG FADF P ++LFVKGN Sbjct: 8 EQSLTEQTLRSLLQQRILILDGAMGTMIQQYKLTEADYRGSEFADFKAPAGERELFVKGN 67 Query: 63 NELLSLTQPHIIQEIHEQYLAAGADLIETNTFGATSVAQDDYHMAHLVYEMNVESARLAR 122 NELL+LTQPHIIQEIHE+YLAAGAD+IETNTFGATSVAQDDYHMAHLVYEMNV++A+LA+ Sbjct: 68 NELLTLTQPHIIQEIHEKYLAAGADIIETNTFGATSVAQDDYHMAHLVYEMNVQAAKLAK 127 Query: 123 AACDKYATPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVAAYLEQTRALVEGG 182 A+C+KY+TPDKPRFVAG LGPTPKTASISPDVNDPAARNV FDQLV AYLEQ RALVEGG Sbjct: 128 ASCEKYSTPDKPRFVAGTLGPTPKTASISPDVNDPAARNVNFDQLVNAYLEQARALVEGG 187 Query: 183 ADVLLVETIFDTLNCKAALFAIDTFFEESGKRLPIMISGTVTDASGRILSGQTVTAFWNS 242 +D+L+VETIFDTLNCKAALFAID FFEE G +P+MISGTVTDASGRILSGQTVTAFWNS Sbjct: 188 SDILMVETIFDTLNCKAALFAIDAFFEEVGYTMPVMISGTVTDASGRILSGQTVTAFWNS 247 Query: 243 IRHARPLTVGLNCALGAALMRPYAEELSKIADTFVCIYPNAGLPNPMSDTGFDETPDVTS 302 +RHA+P+T+GLNCALGA LMRPY EELSKIADTFVCIYPNAGLPNPMSDTGFDETPDVTS Sbjct: 248 VRHAKPITIGLNCALGATLMRPYVEELSKIADTFVCIYPNAGLPNPMSDTGFDETPDVTS 307 Query: 303 ALLKEFAESGFVNVAGGCCGTTPPHIKAIAETVAKIAPRKVPEPTHEMRLSGLEPFTIND 362 +L+KEFA SGF+N+AGGCCGTTP HI AI + IAPR+VP RL+GLEPF I++ Sbjct: 308 SLVKEFATSGFLNIAGGCCGTTPAHINAIYNEIKDIAPRQVPTIPEYTRLAGLEPFVIDE 367 Query: 363 DSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQIIDINMDEAMLDSVAA 422 +SL+VNVGERTNVTGSKAFAR+I+NEQYDEAL+VARQQVENGAQ+IDINMDE MLD+V A Sbjct: 368 NSLFVNVGERTNVTGSKAFARMIINEQYDEALSVARQQVENGAQVIDINMDEGMLDAVKA 427 Query: 423 MTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKSIVNSISMKEGEEKFLREAKL 482 MT FLNLIASEPDIARVPIMIDSSKW VIEAGLKCVQGKSIVNSISMKEGE +FLR+AKL Sbjct: 428 MTHFLNLIASEPDIARVPIMIDSSKWSVIEAGLKCVQGKSIVNSISMKEGEAEFLRQAKL 487 Query: 483 CRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLLVDKLDFPPEDIIFDPNIFAVATGI 542 CRRYGAAVIVMAFDE GQADT+ARKIEIC+RAY LLV +DFPPEDIIFDPNIFA+ATGI Sbjct: 488 CRRYGAAVIVMAFDEKGQADTYARKIEICKRAYDLLVG-MDFPPEDIIFDPNIFAIATGI 546 Query: 543 EEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKAGM 602 EEHNNYAVDFIEATRWI QNLP+AKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKAGM Sbjct: 547 EEHNNYAVDFIEATRWIKQNLPHAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKAGM 606 Query: 603 TMGIVNAGMIGVYDDLPAELRERVEDVVLNRRED------ATERMIEYAATLKAGDKKEE 656 TMGIVNAGM+GVYDDL EL+ERVEDVVLNR D TER+IE A +L AG KKE Sbjct: 607 TMGIVNAGMMGVYDDLAPELKERVEDVVLNRITDPDNLLAPTERLIEIAGSLVAGGKKEA 666 Query: 657 ATLEWRN-----LPVAKRLSHALVHGITQWIVEDTEEVRQQIAADGGRPIHVIEGPLMDG 711 ATLEWR +PV KRLS+A+VHGIT++IVEDTEE R + A+GGRPIHVIEGPLM G Sbjct: 667 ATLEWRGTPEAPVPVEKRLSYAMVHGITEFIVEDTEEARAAVEANGGRPIHVIEGPLMSG 726 Query: 712 MNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIATGEVAKPKGKIVIA 771 MNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIP+IE EK E TG VAKPKGK+VIA Sbjct: 727 MNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPYIEAEKAADEKRTGIVAKPKGKMVIA 786 Query: 772 TVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKADIIGLSGLITPSLE 831 TVKGDVHDIGKNIV+VVLQCNNFEVVNMGVMVP AEILA AK E ADIIGLSGLITPSLE Sbjct: 787 TVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPAAEILAMAKAENADIIGLSGLITPSLE 846 Query: 832 EMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEGPVVYVPDASRAVSVAQ 891 EM ++AKEMQRDPYF +KMPL+IGGATTSRAHTAVKIAP+Y+GP+VYVPDASR+VSV Q Sbjct: 847 EMTHIAKEMQRDPYFKDMKMPLLIGGATTSRAHTAVKIAPHYDGPIVYVPDASRSVSVMQ 906 Query: 892 SLLADEQKTQYVAELNADYERIREQHASKKAAPMLSLAAARANKTKL----DFAPVKPKF 947 +LL E + Y+AE+ ADYE+ R QHA+KK P+L+LA AR NK L +FAPVKPKF Sbjct: 907 NLLTPETRGAYLAEIQADYEKARTQHANKKGVPLLTLADARKNKMALSFAGEFAPVKPKF 966 Query: 948 IGRRLFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVVGEAATKVFQEAQAMLKKI 1007 IGRR+FKN+DL L+A YIDW PFFQTWDLAG YPAIL+D VVGEAA+KVF EAQ MLKKI Sbjct: 967 IGRRVFKNIDLSLIAKYIDWAPFFQTWDLAGAYPAILSDHVVGEAASKVFAEAQDMLKKI 1026 Query: 1008 IDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLRQQTEKPVVDGVARPNQ 1067 IDGRWL+ANGVI+L PANTVNDDDIEIYTD++RSQVAFTYYG+RQQ+ KPV+DGV RPNQ Sbjct: 1027 IDGRWLSANGVIALQPANTVNDDDIEIYTDETRSQVAFTYYGMRQQSVKPVIDGVPRPNQ 1086 Query: 1068 CLSDFIAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSIMLKALADRLAEAFAE 1127 CLSDF+APK GV DY+G+FAVTAGLGIEK EKRF DA DDYS IM K+LADRLAEAFAE Sbjct: 1087 CLSDFVAPK--GVADYVGLFAVTAGLGIEKIEKRFIDAQDDYSGIMFKSLADRLAEAFAE 1144 Query: 1128 YLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEHTVKADVFRTMQCDEIG 1187 Y+HER+R D WGYAADE LS LIKE+Y GIRPAPGYPACP+HTVK D+F +QCDEI Sbjct: 1145 YMHERIRTDFWGYAADEKLSVDALIKEQYQGIRPAPGYPACPDHTVKPDMFNLLQCDEIS 1204 Query: 1188 MQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAERRHVPKEELERWLAPNL 1247 M+LTES+AM P A+VSGFYFAH ++KYF V KIG DQ+ DMA+RR++PK+ LERWLAPNL Sbjct: 1205 MKLTESFAMQPAAAVSGFYFAHKEAKYFSVDKIGTDQLEDMAKRRNLPKDYLERWLAPNL 1264 >dbj|BAG48547.1| methionine synthase [Methylophilus methylotrophus] Length = 1265 Score = 2075 bits (5375), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1002/1256 (79%), Positives = 1108/1256 (88%), Gaps = 20/1256 (1%) Query: 9 TELLLRDLMSQRILILDGAMGTMIQRYKLTEEDYRGQRFADFSVPG--KDLFVKGNNELL 66 TE LR+ +SQRILILDGAMGTMIQRYKLTE DYRG+RF DF P ++LFVKGNNELL Sbjct: 12 TEQWLREALSQRILILDGAMGTMIQRYKLTEADYRGERFKDFQGPAGERELFVKGNNELL 71 Query: 67 SLTQPHIIQEIHEQYLAAGADLIETNTFGATSVAQDDYHMAHLVYEMNVESARLARAACD 126 +LTQPH+IQEIHEQYLAAGAD+IETNTFGATSVAQDDYHMAHLVYEMNVE+A+LA+AAC Sbjct: 72 TLTQPHVIQEIHEQYLAAGADIIETNTFGATSVAQDDYHMAHLVYEMNVEAAKLAKAACV 131 Query: 127 KYATPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVAAYLEQTRALVEGGADVL 186 KY+TPDKPRFVAGALGPTPKTASISPDVNDPAARNV+FDQLV +YLEQ R LVEGGAD+L Sbjct: 132 KYSTPDKPRFVAGALGPTPKTASISPDVNDPAARNVSFDQLVTSYLEQIRGLVEGGADIL 191 Query: 187 LVETIFDTLNCKAALFAIDTFFEESGKRLPIMISGTVTDASGRILSGQTVTAFWNSIRHA 246 +VETIFDTLNCKAALFAID+FFEE GK PIMISGTVTDASGRILSGQTVTAFW+S+RHA Sbjct: 192 MVETIFDTLNCKAALFAIDSFFEEQGKTWPIMISGTVTDASGRILSGQTVTAFWHSVRHA 251 Query: 247 RPLTVGLNCALGAALMRPYAEELSKIADTFVCIYPNAGLPNPMSDTGFDETPDVTSALLK 306 +PLTVGLNCALGA LMRPYAEELSK+ADTFVCIYPNAGLPNPMSDTGFDETPD+T++L+K Sbjct: 252 KPLTVGLNCALGATLMRPYAEELSKVADTFVCIYPNAGLPNPMSDTGFDETPDITASLVK 311 Query: 307 EFAESGFVNVAGGCCGTTPPHIKAIAETVAKIAPRKVPEPTHEMRLSGLEPFTINDDSLY 366 EFA+SGF+N+AGGCCGTTPPHI AI + + PR+VP +LSGLEPF I++ SL+ Sbjct: 312 EFAQSGFINIAGGCCGTTPPHINAIYNAIKDLPPRQVPTLPVTTKLSGLEPFVIDEQSLF 371 Query: 367 VNVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQIIDINMDEAMLDSVAAMTRF 426 VNVGERTNVTGSKAFAR+I+NEQY+EAL+VARQQVENGAQ+IDINMDE MLD+V AMT F Sbjct: 372 VNVGERTNVTGSKAFARMIINEQYEEALSVARQQVENGAQVIDINMDEGMLDAVKAMTHF 431 Query: 427 LNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKSIVNSISMKEGEEKFLREAKLCRRY 486 LNL+ASEPDIARVPIMIDSSKW VIEAGLKCVQGK+IVNSISMKEGE +FLR+AKLCRRY Sbjct: 432 LNLVASEPDIARVPIMIDSSKWSVIEAGLKCVQGKAIVNSISMKEGEAEFLRQAKLCRRY 491 Query: 487 GAAVIVMAFDEVGQADTFARKIEICERAYRLLVDKLDFPPEDIIFDPNIFAVATGIEEHN 546 GA+VIVMAFDE GQADTF RKIEIC+RAY LLV FPPEDIIFDPNIFA+ATGIEEHN Sbjct: 492 GASVIVMAFDEKGQADTFERKIEICKRAYDLLVST-GFPPEDIIFDPNIFAIATGIEEHN 550 Query: 547 NYAVDFIEATRWIHQNLPYAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKAGMTMGI 606 NYAVDFIEATRWI QNLPYA+ISGGVSNVSFSFRGN+PAREAIHTVFLYHAIKAGMTMGI Sbjct: 551 NYAVDFIEATRWIKQNLPYARISGGVSNVSFSFRGNEPAREAIHTVFLYHAIKAGMTMGI 610 Query: 607 VNAGMIGVYDDLPAELRERVEDVVLNRRED------ATERMIEYAATLKAGDKKEEATLE 660 VNAGM+GVYDD+ ELRERVEDVVLNR D ATERMIE A TL AG KK EATL Sbjct: 611 VNAGMVGVYDDIDPELRERVEDVVLNRVVDPANPLAATERMIEIAGTLVAGGKKAEATLA 670 Query: 661 WRN-----LPVAKRLSHALVHGITQWIVEDTEEVRQQIAADGGRPIHVIEGPLMDGMNVV 715 WR +P KRL +ALVHGIT +IV DTEEVRQ I + GGRPIHVIEGPLMDGMNVV Sbjct: 671 WRGTPENPVPATKRLEYALVHGITDFIVADTEEVRQDIMSKGGRPIHVIEGPLMDGMNVV 730 Query: 716 GDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIATGEVAKPKGKIVIATVKG 775 GDLFGQGKMFLPQVVKSARVMK AVAHLIPFIEEEK E TG VAKPKGK+VIATVKG Sbjct: 731 GDLFGQGKMFLPQVVKSARVMKSAVAHLIPFIEEEKAAEERRTGMVAKPKGKVVIATVKG 790 Query: 776 DVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKADIIGLSGLITPSLEEMAY 835 DVHDIGKNIV+VVLQCNNFEVVNMGVMVP AEIL AK E ADIIGLSGLITPSLEEMAY Sbjct: 791 DVHDIGKNIVSVVLQCNNFEVVNMGVMVPAAEILEMAKRENADIIGLSGLITPSLEEMAY 850 Query: 836 VAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEGPVVYVPDASRAVSVAQSLLA 895 +AKEMQRDP+F + PL+IGGATTSRAHTAVKIAPNYEGPV+YVPDASR+VSV Q+LL Sbjct: 851 IAKEMQRDPHFVENQTPLLIGGATTSRAHTAVKIAPNYEGPVIYVPDASRSVSVMQNLLT 910 Query: 896 DEQKTQYVAELNADYERIREQHASKKAAPMLSLAAARANKTKLDF----APVKPKFIGRR 951 E + Y+AE+ ADYE+ R QHA+KK PMLSLA ARAN K +F PVKPKFIGRR Sbjct: 911 PETRGAYLAEIQADYEKARSQHANKKGVPMLSLAEARANAAKFEFTGENTPVKPKFIGRR 970 Query: 952 LFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVVGEAATKVFQEAQAMLKKIIDGR 1011 +FKN+DL L+A YIDWGPFFQTWDLAG YPAIL DEVVGEAATKVF EAQ MLK+IIDGR Sbjct: 971 VFKNIDLALIAQYIDWGPFFQTWDLAGFYPAILKDEVVGEAATKVFAEAQVMLKRIIDGR 1030 Query: 1012 WLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLRQQTEKPVVDGVARPNQCLSD 1071 WL+ANGVI+LLPAN VN+DDIEIYTDDSRSQVA T+YG+RQQT+KPV+DGVARPNQC++D Sbjct: 1031 WLSANGVIALLPANRVNEDDIEIYTDDSRSQVALTWYGMRQQTQKPVIDGVARPNQCMAD 1090 Query: 1072 FIAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSIMLKALADRLAEAFAEYLHE 1131 FIAPK G DYIG+FAVTAGLG+EK FE HDDY++IM K+LADRLAEAFAEY+HE Sbjct: 1091 FIAPK--GTDDYIGLFAVTAGLGMEKRLAEFEKNHDDYNAIMFKSLADRLAEAFAEYMHE 1148 Query: 1132 RVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEHTVKADVFRTMQCDEIGMQLT 1191 RVRKDLWGYAADE+LS+ LIKE+Y GIRPAPGYPACP+HTVK+++F+ +Q EI MQLT Sbjct: 1149 RVRKDLWGYAADESLSNEALIKEQYKGIRPAPGYPACPDHTVKSEMFKVLQASEIEMQLT 1208 Query: 1192 ESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAERRHVPKEELERWLAPNL 1247 +SYAM P A+VSGFY AHP+S+YF V KIG DQ+ DMA+RR+V K LERWLAPNL Sbjct: 1209 DSYAMIPAAAVSGFYLAHPESRYFSVDKIGNDQLEDMAKRRNVDKAWLERWLAPNL 1264 >ref|YP_003049715.1| B12-dependent methionine synthase [Methylotenera mobilis JLW8] gb|ACT49188.1| methionine synthase [Methylotenera mobilis JLW8] Length = 1263 Score = 2060 bits (5338), Expect = 0.0, Method: Compositional matrix adjust. Identities = 995/1255 (79%), Positives = 1110/1255 (88%), Gaps = 19/1255 (1%) Query: 10 ELLLRDLMSQRILILDGAMGTMIQRYKLTEEDYRGQRFADFSVPG--KDLFVKGNNELLS 67 E LR L++QRILILDGAMGTMIQ+YKLTE DYRG+RF DF P ++LFVKGNNELL+ Sbjct: 10 ETQLRALLAQRILILDGAMGTMIQQYKLTEADYRGERFVDFKAPAGERELFVKGNNELLT 69 Query: 68 LTQPHIIQEIHEQYLAAGADLIETNTFGATSVAQDDYHMAHLVYEMNVESARLARAACDK 127 LTQP IIQEIHE+YLAAGAD+IETNTFGAT+VAQDDYHMAHLVYEMNVE+A+LA+AAC K Sbjct: 70 LTQPAIIQEIHEKYLAAGADIIETNTFGATAVAQDDYHMAHLVYEMNVEAAKLAKAACAK 129 Query: 128 YATPDKPRFVAGALGPTPKTASISPDVNDPAARNVTFDQLVAAYLEQTRALVEGGADVLL 187 Y+TPDKPRFVAGALGPTPKTASISPDVNDPAARNV FDQLV AYLEQTRALVEGGAD+L+ Sbjct: 130 YSTPDKPRFVAGALGPTPKTASISPDVNDPAARNVNFDQLVNAYLEQTRALVEGGADILM 189 Query: 188 VETIFDTLNCKAALFAIDTFFEESGKRLPIMISGTVTDASGRILSGQTVTAFWNSIRHAR 247 VETIFDTLNCKAALFAIDT+FEE G+ LPIMISGTVTDASGRILSGQTVTAFW+S+RHA+ Sbjct: 190 VETIFDTLNCKAALFAIDTYFEEVGRTLPIMISGTVTDASGRILSGQTVTAFWHSVRHAK 249 Query: 248 PLTVGLNCALGAALMRPYAEELSKIADTFVCIYPNAGLPNPMSDTGFDETPDVTSALLKE 307 PLT+GLNCALGA LMRPY EELS IADTFVCIYPNAGLPNPMSDTGFDETPDVTS+L+KE Sbjct: 250 PLTIGLNCALGATLMRPYVEELSSIADTFVCIYPNAGLPNPMSDTGFDETPDVTSSLVKE 309 Query: 308 FAESGFVNVAGGCCGTTPPHIKAIAETVAKIAPRKVPEPTHEMRLSGLEPFTINDDSLYV 367 FA+S F+N+AGGCCGTTP HI AI + + PR++P ++LSGLEPF ++DDSL+V Sbjct: 310 FAQSNFLNIAGGCCGTTPAHINAIYNEIKDLPPRQLPALPRTLKLSGLEPFVVDDDSLFV 369 Query: 368 NVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQIIDINMDEAMLDSVAAMTRFL 427 NVGERTNVTGSKAFARLI+NEQYDEAL VARQQVENGAQ+IDINMDE MLD++ AMT FL Sbjct: 370 NVGERTNVTGSKAFARLIINEQYDEALTVARQQVENGAQVIDINMDEGMLDAIKAMTHFL 429 Query: 428 NLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKSIVNSISMKEGEEKFLREAKLCRRYG 487 NL+ASEPDIARVPIMIDSSKW VIEAGLKCVQGK++VNSISMKEGEE+F+R+A+LC+RYG Sbjct: 430 NLVASEPDIARVPIMIDSSKWSVIEAGLKCVQGKAVVNSISMKEGEEEFIRQAQLCKRYG 489 Query: 488 AAVIVMAFDEVGQADTFARKIEICERAYRLLVDKLDFPPEDIIFDPNIFAVATGIEEHNN 547 AA IVMAFDE GQADTF RKIEIC+RAY LLV+KLDFPPEDIIFDPNIFA+ATGIEEHNN Sbjct: 490 AAAIVMAFDEKGQADTFERKIEICKRAYDLLVEKLDFPPEDIIFDPNIFAIATGIEEHNN 549 Query: 548 YAVDFIEATRWIHQNLPYAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKAGMTMGIV 607 YAVDFI AT WI Q+LPYAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKAGMTMGIV Sbjct: 550 YAVDFINATHWIKQHLPYAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKAGMTMGIV 609 Query: 608 NAGMIGVYDDLPAELRERVEDVVLNRRED------ATERMIEYAATLKAGDKKEEATLEW 661 NAGM+GVYDDL EL+ERVEDVVLNR D ATERMIE A+TL AG KKE ATLEW Sbjct: 610 NAGMMGVYDDLAPELKERVEDVVLNRVVDPNNPLAATERMIEIASTLVAGGKKEAATLEW 669 Query: 662 RN-----LPVAKRLSHALVHGITQWIVEDTEEVRQQIAADGGRPIHVIEGPLMDGMNVVG 716 R +PV KRLSHA+VHGIT++IV+DTEE RQ++AA GGRPIHVIEGPLMDGMNVVG Sbjct: 670 RGTPENPVPVEKRLSHAMVHGITEFIVDDTEEARQKVAAAGGRPIHVIEGPLMDGMNVVG 729 Query: 717 DLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIATGEVAKPKGKIVIATVKGD 776 DLFGQGKMFLPQVVKSARVMK AVAHLIPFIE EK E TG VAKPKGK+VIATVKGD Sbjct: 730 DLFGQGKMFLPQVVKSARVMKSAVAHLIPFIEAEKAADEARTGIVAKPKGKMVIATVKGD 789 Query: 777 VHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKADIIGLSGLITPSLEEMAYV 836 VHDIGKNIV+VVLQCNNFEVVNMGVMVP +EILA AK E ADIIGLSGLITPSLEEMA+V Sbjct: 790 VHDIGKNIVSVVLQCNNFEVVNMGVMVPASEILAMAKAENADIIGLSGLITPSLEEMAHV 849 Query: 837 AKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEGPVVYVPDASRAVSVAQSLLAD 896 A+EMQRDPYF+ KMPL+IGGATTSRAHTAVKIAP+Y+GP+VYV DASR+V+V Q+LL Sbjct: 850 AREMQRDPYFSEQKMPLLIGGATTSRAHTAVKIAPHYDGPIVYVADASRSVTVMQNLLTP 909 Query: 897 EQKTQYVAELNADYERIREQHASKKAAPMLSLAAARANKTKLDF----APVKPKFIGRRL 952 E + Y+AE+ ADYE+ R QHA+KK PML++A ARANK L F APVKPKFIGRR Sbjct: 910 ETRGAYLAEIQADYEKARTQHANKKGTPMLTIAEARANKADLSFAGADAPVKPKFIGRRE 969 Query: 953 FKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVVGEAATKVFQEAQAMLKKIIDGRW 1012 KN DL ++A YIDW PFFQTWDLAG YPAIL DEVVG+AATK+F EAQ MLKKIIDGRW Sbjct: 970 IKNADLSVIAQYIDWTPFFQTWDLAGFYPAILKDEVVGDAATKLFNEAQMMLKKIIDGRW 1029 Query: 1013 LTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLRQQTEKPVVDGVARPNQCLSDF 1072 LTANGV++L PAN DDDIEIYTD++R+ +AFTYYG+RQQT KPV+DG+ARPNQCL+DF Sbjct: 1030 LTANGVVALHPANRTGDDDIEIYTDETRTNIAFTYYGMRQQTVKPVIDGIARPNQCLADF 1089 Query: 1073 IAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSIMLKALADRLAEAFAEYLHER 1132 IAPK G DYIG+FAVTAGLGIEK+E+RFE AHDDYSSIMLKALADRLAEAFAEY+HER Sbjct: 1090 IAPK--GTPDYIGLFAVTAGLGIEKHEQRFEAAHDDYSSIMLKALADRLAEAFAEYMHER 1147 Query: 1133 VRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEHTVKADVFRTMQCDEIGMQLTE 1192 VR D WGYA +EN++ LIKE+Y GIRPAPGYPACP+HTVK D+F+ +Q + I M LTE Sbjct: 1148 VRVDFWGYAPNENVTKEGLIKEQYQGIRPAPGYPACPDHTVKPDMFKLLQAEAISMALTE 1207 Query: 1193 SYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAERRHVPKEELERWLAPNL 1247 S+AM PGA+VSGFYFAHP+SKYF V KIG DQ+ DMA+RR + KE LERWLAPNL Sbjct: 1208 SFAMSPGAAVSGFYFAHPESKYFSVDKIGIDQLEDMAKRRGLTKEYLERWLAPNL 1262