BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0020.0233.p (671 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003773696.1| diguanylate cyclase [Herbaspirillum seropedi... 1347 0.0 ref|YP_001758065.1| diguanylate cyclase/phosphodiesterase [Methy... 587 e-165 ref|YP_003066785.1| diguanylate cyclase/phosphodiesterase [Methy... 577 e-162 ref|YP_001638478.1| diguanylate cyclase [Methylobacterium extorq... 575 e-161 ref|YP_002961982.1| diguanylate cyclase/phosphodiesterase, GGDEF... 573 e-161 ref|YP_002419810.1| diguanylate cyclase/phosphodiesterase [Methy... 570 e-160 ref|YP_676139.1| diguanylate cyclase/phosphodiesterase [Mesorhiz... 431 e-118 ref|ZP_04681986.1| diguanylate cyclase (GGDEF) domain-containing... 411 e-112 ref|YP_001371884.1| diguanylate cyclase/phosphodiesterase [Ochro... 399 e-108 ref|ZP_00051942.2| COG5001: Predicted signal transduction protei... 343 6e-92 >ref|YP_003773696.1| diguanylate cyclase [Herbaspirillum seropedicae SmR1] gb|ADJ61788.1| diguanylate cyclase protein [Herbaspirillum seropedicae SmR1] Length = 696 Score = 1347 bits (3485), Expect = 0.0, Method: Compositional matrix adjust. Identities = 671/671 (100%), Positives = 671/671 (100%) Query: 1 MFRMKMFHTPTPQTGVQAPAAQLSLQQLIRADQLAALRQTVLLSIPVNMVLGAICTFVAW 60 MFRMKMFHTPTPQTGVQAPAAQLSLQQLIRADQLAALRQTVLLSIPVNMVLGAICTFVAW Sbjct: 26 MFRMKMFHTPTPQTGVQAPAAQLSLQQLIRADQLAALRQTVLLSIPVNMVLGAICTFVAW 85 Query: 61 RAGHLAIALLWLACSGMVNLLRILACRLPVQRVAALVQRIAAPGAGVIDLNLRVHWMLAL 120 RAGHLAIALLWLACSGMVNLLRILACRLPVQRVAALVQRIAAPGAGVIDLNLRVHWMLAL Sbjct: 86 RAGHLAIALLWLACSGMVNLLRILACRLPVQRVAALVQRIAAPGAGVIDLNLRVHWMLAL 145 Query: 121 CSGLVWAGVALLCAGYTAPGTLFYLTCVCGITAGAVTHGFAYARIPIAFITPPLLAIIAS 180 CSGLVWAGVALLCAGYTAPGTLFYLTCVCGITAGAVTHGFAYARIPIAFITPPLLAIIAS Sbjct: 146 CSGLVWAGVALLCAGYTAPGTLFYLTCVCGITAGAVTHGFAYARIPIAFITPPLLAIIAS 205 Query: 181 LVLVEPDTTRVALAAAVLLYLGALIRGSKVSEGLVSHASALKNEATTASQALEVAHRDLH 240 LVLVEPDTTRVALAAAVLLYLGALIRGSKVSEGLVSHASALKNEATTASQALEVAHRDLH Sbjct: 206 LVLVEPDTTRVALAAAVLLYLGALIRGSKVSEGLVSHASALKNEATTASQALEVAHRDLH 265 Query: 241 QFAERMRYQAEHDLLTGLLGRAGFMAAAQAMAARREEVLCMMFLDLDGFKVINDAYGHDA 300 QFAERMRYQAEHDLLTGLLGRAGFMAAAQAMAARREEVLCMMFLDLDGFKVINDAYGHDA Sbjct: 266 QFAERMRYQAEHDLLTGLLGRAGFMAAAQAMAARREEVLCMMFLDLDGFKVINDAYGHDA 325 Query: 301 GDQVLVEVARRLQGCLPAGATLARLGGDEFVILYALDAQAELPELLARRLIEVVRQPFAR 360 GDQVLVEVARRLQGCLPAGATLARLGGDEFVILYALDAQAELPELLARRLIEVVRQPFAR Sbjct: 326 GDQVLVEVARRLQGCLPAGATLARLGGDEFVILYALDAQAELPELLARRLIEVVRQPFAR 385 Query: 361 LAHRHIGLSLGITLSDRDDIDEMLVCSDAAMYQAKRRGRNQFCVFNETLNAHLQMKRDVE 420 LAHRHIGLSLGITLSDRDDIDEMLVCSDAAMYQAKRRGRNQFCVFNETLNAHLQMKRDVE Sbjct: 386 LAHRHIGLSLGITLSDRDDIDEMLVCSDAAMYQAKRRGRNQFCVFNETLNAHLQMKRDVE 445 Query: 421 RDLAGALARRELAVWFQPIVQHDGQTLDGFEALLRWQHGKHGAIAAPDLIEIAALAGLSE 480 RDLAGALARRELAVWFQPIVQHDGQTLDGFEALLRWQHGKHGAIAAPDLIEIAALAGLSE Sbjct: 446 RDLAGALARRELAVWFQPIVQHDGQTLDGFEALLRWQHGKHGAIAAPDLIEIAALAGLSE 505 Query: 481 ELLRFILEEVAGMIAFLQSSGRSDLRISMNISPREMERLVVDELVVSMLKAHRLPARMLE 540 ELLRFILEEVAGMIAFLQSSGRSDLRISMNISPREMERLVVDELVVSMLKAHRLPARMLE Sbjct: 506 ELLRFILEEVAGMIAFLQSSGRSDLRISMNISPREMERLVVDELVVSMLKAHRLPARMLE 565 Query: 541 IEITEETALDLQAATQTLVALALQGVRIAIDDFGVGYSSLGFLRQMQVSRVKIDRSFVTG 600 IEITEETALDLQAATQTLVALALQGVRIAIDDFGVGYSSLGFLRQMQVSRVKIDRSFVTG Sbjct: 566 IEITEETALDLQAATQTLVALALQGVRIAIDDFGVGYSSLGFLRQMQVSRVKIDRSFVTG 625 Query: 601 LADQTENQALVSAVLQLAGSFGFQVVAEGVESAEDLQTLQAMHCHAMQGYYFAPPMPAAQ 660 LADQTENQALVSAVLQLAGSFGFQVVAEGVESAEDLQTLQAMHCHAMQGYYFAPPMPAAQ Sbjct: 626 LADQTENQALVSAVLQLAGSFGFQVVAEGVESAEDLQTLQAMHCHAMQGYYFAPPMPAAQ 685 Query: 661 ARARIEALAQA 671 ARARIEALAQA Sbjct: 686 ARARIEALAQA 696 >ref|YP_001758065.1| diguanylate cyclase/phosphodiesterase [Methylobacterium radiotolerans JCM 2831] gb|ACB27382.1| diguanylate cyclase/phosphodiesterase [Methylobacterium radiotolerans JCM 2831] Length = 675 Score = 587 bits (1514), Expect = e-165, Method: Compositional matrix adjust. Identities = 327/643 (50%), Positives = 406/643 (63%), Gaps = 6/643 (0%) Query: 26 QQLIRADQLAALRQTVLLSIPVNMVLGAICTFVAWRAGHLAIALLWLACSGMVNLLRILA 85 LIR DQL A+R +VL +IPVNM+LG VA+R+GH + +W A S VNLLRI Sbjct: 28 NALIRRDQLDAMRGSVLAAIPVNMLLGLASILVAYRSGHGTVGAVWFAASTSVNLLRIAL 87 Query: 86 CRLP---VQRVAALVQRIAAPGAGVIDLNLRVHWMLALCSGLVWAGVALLCAGYTAPGTL 142 CR+P + A + +AA A +D +LR A SGLVWA LLC GYT TL Sbjct: 88 CRIPCLGLALTADMTPSLAAAAARSVDRHLRACTFAAFLSGLVWACQPLLCDGYTTAETL 147 Query: 143 FYLTCVCGITAGAVTHGFAYARIPIAFITPPLLAIIASLVLVEPDTTRVALAAAVLLYLG 202 FYLT CG+TAGAVTHG AYARIP+AFI PLL++ A L D R LAA VLLY Sbjct: 148 FYLTITCGVTAGAVTHGTAYARIPLAFIALPLLSVTACLAYAG-DFDRNCLAACVLLYFL 206 Query: 203 ALIRGSKVSEGLVSHASALKNEATTASQALEVAHRDLHQFAERMRYQAEHDLLTGLLGRA 262 AL + SE + AS LKNEA +++ AH + MR++A HD LTGLL RA Sbjct: 207 ALTHTAFRSEAVFRDASRLKNEAHALARSRAEAHASASALVDEMRWRATHDDLTGLLNRA 266 Query: 263 GFMAAAQAMAARREEVLCMMFLDLDGFKVINDAYGHDAGDQVLVEVARRLQGCLPAGATL 322 GF+ A + R L ++ LDLDGFK +ND YGH AGD+VLVEVARRL LP Sbjct: 267 GFLQATENRL--RTGTLSLLMLDLDGFKFVNDVYGHKAGDRVLVEVARRLNDALPENGLT 324 Query: 323 ARLGGDEFVILYALDAQAELPELLARRLIEVVRQPFARLAHRHIGLSLGITLSDRDDIDE 382 ARLGGDEF +LY ++A LI V QPF +G+S+G+ S + E Sbjct: 325 ARLGGDEFAVLYDPVTSGVPDAVMAANLITAVSQPFDGFDAGRLGVSIGVHASREPSLTE 384 Query: 383 MLVCSDAAMYQAKRRGRNQFCVFNETLNAHLQMKRDVERDLAGALARRELAVWFQPIVQH 442 ML C+D A+Y AK GRN+F VF+ +L LQM+RD+ERDL+ AL VWFQPI Sbjct: 385 MLSCADEALYAAKAAGRNRFRVFDSSLRERLQMRRDLERDLSQALVENAPKVWFQPIYAG 444 Query: 443 DGQTLDGFEALLRWQHGKHGAIAAPDLIEIAALAGLSEELLRFILEEVAGMIAFLQSSGR 502 DG+TL G EAL+RW+H + G IA PDLI AA+AGL+E LLR+ILE+V M+ L G Sbjct: 445 DGRTLVGLEALIRWEHPRLGWIAPPDLIAAAAMAGLTESLLRYILEQVCAMLEILHRRGL 504 Query: 503 SDLRISMNISPREMERLVVDELVVSMLKAHRLPARMLEIEITEETALDLQAATQTLVALA 562 +R++MN+SPREM ++ VDE+V+ L LP MLEIEITEETALD+ A L AL+ Sbjct: 505 GSVRVAMNVSPREMAQVPVDEIVIERLSLLGLPPTMLEIEITEETALDIGAVQGKLQALS 564 Query: 563 LQGVRIAIDDFGVGYSSLGFLRQMQVSRVKIDRSFVTGLADQTENQALVSAVLQLAGSFG 622 G+R+A+DDFG+GYSSL LRQ++ R+KIDRSFVTGL + + LV AVL L G Sbjct: 565 RAGIRVALDDFGIGYSSLSSLRQLKADRIKIDRSFVTGLGASDDKRGLVLAVLGLGRLLG 624 Query: 623 FQVVAEGVESAEDLQTLQAMHCHAMQGYYFAPPMPAAQARARI 665 VVAEGVESAEDL LQAM C +QGY+ PMP A A + Sbjct: 625 LDVVAEGVESAEDLNILQAMGCPFLQGYHLGRPMPVADLEATL 667 >ref|YP_003066785.1| diguanylate cyclase/phosphodiesterase [Methylobacterium extorquens DM4] emb|CAX22768.1| putative diguanylate cyclase/phosphodiesterase, GGDEF and EAL domains [Methylobacterium extorquens DM4] Length = 668 Score = 577 bits (1487), Expect = e-162, Method: Compositional matrix adjust. Identities = 330/663 (49%), Positives = 422/663 (63%), Gaps = 17/663 (2%) Query: 19 PAAQLSLQQLIRADQLAALRQTVLLSIPVNMVLGAICTFVAWRAGHLAIALLWLACSGMV 78 P+ + L +LIR DQL A+R +V ++PVN++LG VA +GH A+ LW + S Sbjct: 5 PSTEPHLDRLIRRDQLEAVRASVQQALPVNVLLGLAGFLVALHSGHGALGALWFSASTAF 64 Query: 79 NLLRILACRLPVQRVAALVQRIAAP-----GAGVIDLNLRVHWMLALCSGLVWAGVALLC 133 N LR CR P +A R AP A ID +L + + AL SG VWA + LLC Sbjct: 65 NGLRFGLCRAPCAGLAMSPGR--APISEEAAARSIDRHLWLACLAALLSGSVWALLPLLC 122 Query: 134 AGYTAPGTLFYLTCVCGITAGAVTHGFAYARIPIAFITPPLLAIIASLVLVEPDTTRVAL 193 GYT+ TLFYLT CGITAGAVTHG AYARIPI FITPPL+++ L+ V + L Sbjct: 123 DGYTSAQTLFYLTVTCGITAGAVTHGIAYARIPICFITPPLVSVAGCLLAVG-GFDQTCL 181 Query: 194 AAAVLLYLGALIRGSKVSEGLVSHASALKNEATTASQALEVAHRDLHQFAERMRYQAEHD 253 AA VLLYL ALIR S +E S LKNEAT ++A + AH AE MR +A HD Sbjct: 182 AATVLLYLAALIRSSIATERGFRETSRLKNEATALAEARKAAHASASALAEEMRERATHD 241 Query: 254 LLTGLLGRAGFMAAAQAMAARREEVLCMMFLDLDGFKVINDAYGHDAGDQVLVEVARRLQ 313 LTGLL RAGF+ A+ A V C+M LDLDGFK +ND YGH GD+VL EVARR++ Sbjct: 242 GLTGLLNRAGFIQRAEEQLAAGASV-CLMLLDLDGFKSVNDVYGHSTGDRVLAEVARRIR 300 Query: 314 GCLPAGATLARLGGDEFVILYALDAQAELPELLARRLIEVVRQPFARLAHRHIGLSLGIT 373 +P ARLGGDEF ++Y E P LA RLI V QPF +G+S+GI Sbjct: 301 VAVPVDCDAARLGGDEFALVYDTARVIESPAALAERLIRTVAQPFESFDTGRLGMSIGIC 360 Query: 374 LSDRDDIDEMLVCSDAAMYQAKRRGRNQFCVFNETLNAHLQMKRDVERDLAGALARRELA 433 D + +L C+D A+Y AK GRN F +F++ L+ L+M+RD ERDL+ ALA EL Sbjct: 361 HRPSDSLTHLLSCADEALYAAKHSGRNHFRLFDDGLSTRLEMRRDCERDLSQALAEGELE 420 Query: 434 VWFQPIVQHDGQTLDGFEALLRWQHGKHGAIAAPDLIEIAALAGLSEELLRFILEEVAGM 493 VWFQPI DG+++ EAL+RW H HG + DLI AA+AGL+E LLRFILE+V M Sbjct: 421 VWFQPIFGPDGRSVTNLEALVRWHHPVHGWVPPADLISAAAMAGLTESLLRFILEQVCAM 480 Query: 494 IAFLQSSGRSDLRISMNISPREMERLVVDELVVSMLKAHRLPARMLEIEITEETALDLQA 553 + L++ G DL ++MN+SPREM ++ VDE+V+ L+ LPA LEIEITEETALD++A Sbjct: 481 LCALRTRGLHDLSVAMNVSPREMAQIAVDEIVLGRLRVLGLPATALEIEITEETALDIEA 540 Query: 554 ATQTLVALALQGVRIAIDDFGVGYSSLGFLRQMQVSRVKIDRSFVTGLADQTENQALVSA 613 L+AL+ G+R+A+DDFG GYSSL +RQ++ RVKIDRS VTGL++ + + LV A Sbjct: 541 VQGKLLALSRAGIRMALDDFGTGYSSLASVRQLRADRVKIDRSLVTGLSEAEDKRGLVQA 600 Query: 614 VLQLAGSFGFQVVAEGVESAEDLQTLQAMHCHAMQGYYFAPPMP--------AAQARARI 665 VL L + G +VVAEG+E+AEDL TLQAM C MQGYY P P A+ RA + Sbjct: 601 VLGLGRALGLEVVAEGIETAEDLATLQAMGCPFMQGYYLGRPQPRDDILRFLDARPRADV 660 Query: 666 EAL 668 +AL Sbjct: 661 QAL 663 >ref|YP_001638478.1| diguanylate cyclase [Methylobacterium extorquens PA1] gb|ABY29407.1| diguanylate cyclase [Methylobacterium extorquens PA1] Length = 697 Score = 575 bits (1481), Expect = e-161, Method: Compositional matrix adjust. Identities = 328/663 (49%), Positives = 422/663 (63%), Gaps = 17/663 (2%) Query: 19 PAAQLSLQQLIRADQLAALRQTVLLSIPVNMVLGAICTFVAWRAGHLAIALLWLACSGMV 78 P+ + L +LIR DQL A+R +V ++PVN++LG VA +GH A+ LW + S Sbjct: 34 PSTEPHLDRLIRRDQLEAVRASVQQALPVNVLLGLAGFLVALHSGHGALGALWFSASTAF 93 Query: 79 NLLRILACRLPVQRVAALVQRIAAP-----GAGVIDLNLRVHWMLALCSGLVWAGVALLC 133 N LR CR P +A R AP A ID +L + + AL SG VWA + LLC Sbjct: 94 NGLRFGLCRAPCAGLAMSPGR--APISEEAAARSIDRHLWLACLAALLSGSVWALLPLLC 151 Query: 134 AGYTAPGTLFYLTCVCGITAGAVTHGFAYARIPIAFITPPLLAIIASLVLVEPDTTRVAL 193 GYT+ TLFYLT CGITAGAVTHG AYARIPI FITPPL+++ L+ V + L Sbjct: 152 DGYTSAQTLFYLTVTCGITAGAVTHGIAYARIPICFITPPLVSVAGCLLAVG-GFDQTCL 210 Query: 194 AAAVLLYLGALIRGSKVSEGLVSHASALKNEATTASQALEVAHRDLHQFAERMRYQAEHD 253 AA VLLYL ALIR S +E S LKNEAT ++A + AH AE MR +A HD Sbjct: 211 AATVLLYLAALIRSSIATERGFRETSRLKNEATALAEARKAAHASASALAEEMRERATHD 270 Query: 254 LLTGLLGRAGFMAAAQAMAARREEVLCMMFLDLDGFKVINDAYGHDAGDQVLVEVARRLQ 313 LTGLL RAGF+ A+ A V C+M LDLDGFK +ND YGH GD+VL EVARR++ Sbjct: 271 GLTGLLNRAGFIQRAEEQLAAGASV-CLMLLDLDGFKSVNDVYGHSTGDRVLAEVARRIR 329 Query: 314 GCLPAGATLARLGGDEFVILYALDAQAELPELLARRLIEVVRQPFARLAHRHIGLSLGIT 373 +P ARLGGDEF ++Y E P LA RLI V QPF +G+S+GI Sbjct: 330 VAVPVDCDAARLGGDEFALVYDTARVIESPAALAERLIRTVAQPFESFDTGRLGMSIGIC 389 Query: 374 LSDRDDIDEMLVCSDAAMYQAKRRGRNQFCVFNETLNAHLQMKRDVERDLAGALARRELA 433 D + +L C+D A+Y AK GRN F +F++ L+ L+M+RD ERDL+ ALA EL Sbjct: 390 HRPSDSLTHLLSCADEALYAAKHSGRNHFHLFDDGLSTRLEMRRDCERDLSQALAEGELE 449 Query: 434 VWFQPIVQHDGQTLDGFEALLRWQHGKHGAIAAPDLIEIAALAGLSEELLRFILEEVAGM 493 VWFQPI DG+++ EAL+RW H HG + DLI AA+AGL+E LLRFILE+V M Sbjct: 450 VWFQPIFGPDGRSVTNLEALVRWHHPVHGWVPPADLISAAAMAGLTESLLRFILEQVCAM 509 Query: 494 IAFLQSSGRSDLRISMNISPREMERLVVDELVVSMLKAHRLPARMLEIEITEETALDLQA 553 + L++ G DL ++MN+SPREM ++ VDE+V+ L+ LPA LEIEITEETALD++A Sbjct: 510 LCALRTRGLHDLSVAMNVSPREMAQIAVDEIVLGRLRVLGLPATALEIEITEETALDIEA 569 Query: 554 ATQTLVALALQGVRIAIDDFGVGYSSLGFLRQMQVSRVKIDRSFVTGLADQTENQALVSA 613 L+AL+ G+R+A+DDFG GYSSL +RQ++ RVKIDRS VTGL++ + + LV A Sbjct: 570 VQGKLLALSRAGIRMALDDFGTGYSSLASVRQLRADRVKIDRSLVTGLSEAEDKRGLVQA 629 Query: 614 VLQLAGSFGFQVVAEGVESAEDLQTLQAMHCHAMQGYYFAPPMP--------AAQARARI 665 VL L + G +VVAEG+E+A+DL TLQAM C MQGY+ P P A+ RA + Sbjct: 630 VLGLGRALGLEVVAEGIETADDLATLQAMGCPFMQGYHLGRPQPRDDILRFLDARPRADV 689 Query: 666 EAL 668 +AL Sbjct: 690 QAL 692 >ref|YP_002961982.1| diguanylate cyclase/phosphodiesterase, GGDEF and EAL domains [methylobacterium extorquens AM1] gb|ACS38705.1| putative diguanylate cyclase/phosphodiesterase, GGDEF and EAL domains [Methylobacterium extorquens AM1] Length = 668 Score = 573 bits (1476), Expect = e-161, Method: Compositional matrix adjust. Identities = 328/663 (49%), Positives = 422/663 (63%), Gaps = 17/663 (2%) Query: 19 PAAQLSLQQLIRADQLAALRQTVLLSIPVNMVLGAICTFVAWRAGHLAIALLWLACSGMV 78 P+ + L +LIR DQL A+R +V ++PVN++LG VA +GH A+ LW + S Sbjct: 5 PSTEPHLDRLIRRDQLEAVRASVQQALPVNVLLGLAGFLVALHSGHGALGALWFSASTAF 64 Query: 79 NLLRILACRLPVQRVAALVQRIAAP-----GAGVIDLNLRVHWMLALCSGLVWAGVALLC 133 N LR CR P +A R AP A ID +L + + AL SG VWA + LLC Sbjct: 65 NGLRFGLCRAPCAGLAMSPGR--APISEEAAARSIDRHLWLACLAALLSGSVWALLPLLC 122 Query: 134 AGYTAPGTLFYLTCVCGITAGAVTHGFAYARIPIAFITPPLLAIIASLVLVEPDTTRVAL 193 GYT+ TLFYLT CGITAGAVTHG AYARIPI FITPPL+++ L+ V + L Sbjct: 123 DGYTSAQTLFYLTVTCGITAGAVTHGIAYARIPICFITPPLVSVAGCLLAVG-GFDQTCL 181 Query: 194 AAAVLLYLGALIRGSKVSEGLVSHASALKNEATTASQALEVAHRDLHQFAERMRYQAEHD 253 AA VLLYL ALIR S +E S LKNEAT ++A + AH AE MR +A HD Sbjct: 182 AATVLLYLAALIRSSIATERGFRETSRLKNEATALAEARKAAHASASALAEEMRERATHD 241 Query: 254 LLTGLLGRAGFMAAAQAMAARREEVLCMMFLDLDGFKVINDAYGHDAGDQVLVEVARRLQ 313 LTGLL RAGF+ A+ A V C+M LDLDGFK +ND YGH GD+VL EVARR++ Sbjct: 242 GLTGLLNRAGFIQRAEEQLAAGASV-CLMLLDLDGFKSVNDVYGHSTGDRVLAEVARRIR 300 Query: 314 GCLPAGATLARLGGDEFVILYALDAQAELPELLARRLIEVVRQPFARLAHRHIGLSLGIT 373 +P ARLGGDEF ++Y E P LA RLI V QPF +G+S+GI Sbjct: 301 VAVPVDCDAARLGGDEFALVYDSARVIESPAALAERLIRTVAQPFESFDTGRLGMSIGIC 360 Query: 374 LSDRDDIDEMLVCSDAAMYQAKRRGRNQFCVFNETLNAHLQMKRDVERDLAGALARRELA 433 D + +L C+D A+Y AK GRN F +F++ L+ L+M+RD ERDL+ ALA EL Sbjct: 361 HRPSDSLTHLLSCADEALYAAKHSGRNHFRLFDDGLSTRLEMRRDCERDLSQALAEGELE 420 Query: 434 VWFQPIVQHDGQTLDGFEALLRWQHGKHGAIAAPDLIEIAALAGLSEELLRFILEEVAGM 493 VWFQPI DG+++ EAL+RW H HG + DLI AA+AGL+E LLRFILE+V M Sbjct: 421 VWFQPIFGPDGRSVTNLEALVRWHHPVHGWVPPADLISAAAMAGLTESLLRFILEQVCAM 480 Query: 494 IAFLQSSGRSDLRISMNISPREMERLVVDELVVSMLKAHRLPARMLEIEITEETALDLQA 553 + L++ G DL ++MN+SPREM ++ VDE+V+ L+ LPA LEIEITEETALD++A Sbjct: 481 LCALRTRGLHDLSVAMNVSPREMAQIAVDEIVLGRLRVLGLPATALEIEITEETALDIEA 540 Query: 554 ATQTLVALALQGVRIAIDDFGVGYSSLGFLRQMQVSRVKIDRSFVTGLADQTENQALVSA 613 L+AL+ G+R+A+DDFG GYSSL +RQ++ RVKIDRS VTGL++ + + LV A Sbjct: 541 VQGKLLALSRAGIRMALDDFGTGYSSLASVRQLRADRVKIDRSLVTGLSEAEDKRGLVQA 600 Query: 614 VLQLAGSFGFQVVAEGVESAEDLQTLQAMHCHAMQGYYFAPPMP--------AAQARARI 665 VL L + G +VVAEG+E+A+DL TLQAM C MQGY+ P P A+ RA + Sbjct: 601 VLGLGRALGLEVVAEGIETADDLATLQAMGCPFMQGYHLGRPQPRDDILRFLDARPRADV 660 Query: 666 EAL 668 +AL Sbjct: 661 QAL 663 >ref|YP_002419810.1| diguanylate cyclase/phosphodiesterase [Methylobacterium chloromethanicum CM4] gb|ACK81882.1| diguanylate cyclase/phosphodiesterase [Methylobacterium chloromethanicum CM4] Length = 668 Score = 570 bits (1470), Expect = e-160, Method: Compositional matrix adjust. Identities = 327/663 (49%), Positives = 421/663 (63%), Gaps = 17/663 (2%) Query: 19 PAAQLSLQQLIRADQLAALRQTVLLSIPVNMVLGAICTFVAWRAGHLAIALLWLACSGMV 78 P+ + L +LIR DQL A+R +V ++PVN++LG VA +GH A+ LW + S Sbjct: 5 PSTEPHLDRLIRRDQLEAVRASVQQALPVNVLLGLAGFLVALHSGHGALGALWFSASTAF 64 Query: 79 NLLRILACRLPVQRVAALVQRIAAP-----GAGVIDLNLRVHWMLALCSGLVWAGVALLC 133 N LR CR P +A R AP A ID +L + + AL SG VWA + LLC Sbjct: 65 NGLRFGLCRAPCAGLAMSPGR--APISEEAAARSIDRHLWLACLAALLSGSVWALLPLLC 122 Query: 134 AGYTAPGTLFYLTCVCGITAGAVTHGFAYARIPIAFITPPLLAIIASLVLVEPDTTRVAL 193 GYT+ TLFYLT CGITAGAVTHG AYARIPI FITPPL+++ L+ V + L Sbjct: 123 DGYTSAQTLFYLTVTCGITAGAVTHGIAYARIPICFITPPLVSVAGCLLAVG-GFDQTCL 181 Query: 194 AAAVLLYLGALIRGSKVSEGLVSHASALKNEATTASQALEVAHRDLHQFAERMRYQAEHD 253 AA VLLYL ALIR S +E S LKNEAT ++A + AH AE MR +A HD Sbjct: 182 AATVLLYLAALIRSSIATERGFRETSRLKNEATALAEARKAAHASASALAEEMRERATHD 241 Query: 254 LLTGLLGRAGFMAAAQAMAARREEVLCMMFLDLDGFKVINDAYGHDAGDQVLVEVARRLQ 313 LTGLL RAGF+ A+ A V C+M LDLDGFK +ND YGH GD+VL EVA R++ Sbjct: 242 GLTGLLNRAGFIQRAEEQLAAGASV-CLMLLDLDGFKSVNDVYGHSTGDRVLAEVAHRIR 300 Query: 314 GCLPAGATLARLGGDEFVILYALDAQAELPELLARRLIEVVRQPFARLAHRHIGLSLGIT 373 +P ARLGGDEF ++Y E P LA RLI V QPF +G+S+GI Sbjct: 301 VAVPVDCDAARLGGDEFALVYDSARVIESPAALAERLIRTVAQPFESFDTGRLGMSIGIC 360 Query: 374 LSDRDDIDEMLVCSDAAMYQAKRRGRNQFCVFNETLNAHLQMKRDVERDLAGALARRELA 433 D + +L C+D A+Y AK GRN F +F++ L+ L+M+RD ERDL+ ALA EL Sbjct: 361 HRPSDSLTHLLSCADEALYAAKHSGRNHFRLFDDGLSTRLEMRRDCERDLSQALAEGELE 420 Query: 434 VWFQPIVQHDGQTLDGFEALLRWQHGKHGAIAAPDLIEIAALAGLSEELLRFILEEVAGM 493 VWFQPI DG+++ EAL+RW H HG + DLI AA+AGL+E LLRFILE+V M Sbjct: 421 VWFQPIFGPDGRSVTNLEALVRWHHPVHGWVPPADLISAAAMAGLTESLLRFILEQVCAM 480 Query: 494 IAFLQSSGRSDLRISMNISPREMERLVVDELVVSMLKAHRLPARMLEIEITEETALDLQA 553 + L++ G DL ++MN+SPREM ++ VDE+V+ L+ LPA LEIEITEETALD++A Sbjct: 481 LCALRTRGLHDLSVAMNVSPREMAQIAVDEIVLGRLRVLGLPATALEIEITEETALDIEA 540 Query: 554 ATQTLVALALQGVRIAIDDFGVGYSSLGFLRQMQVSRVKIDRSFVTGLADQTENQALVSA 613 L+AL+ G+R+A+DDFG GYSSL +RQ++ RVKIDRS VTGL++ + + LV A Sbjct: 541 VQGKLLALSRAGIRMALDDFGTGYSSLASVRQLRADRVKIDRSLVTGLSEAEDKRGLVQA 600 Query: 614 VLQLAGSFGFQVVAEGVESAEDLQTLQAMHCHAMQGYYFAPPMP--------AAQARARI 665 VL L + G +VVAEG+E+A+DL TLQAM C MQGY+ P P A+ RA + Sbjct: 601 VLGLGRALGLEVVAEGIETADDLATLQAMGCPFMQGYHLGRPQPRDDILRFLDARPRADV 660 Query: 666 EAL 668 +AL Sbjct: 661 QAL 663 >ref|YP_676139.1| diguanylate cyclase/phosphodiesterase [Mesorhizobium sp. BNC1] gb|ABG64974.1| diguanylate cyclase/phosphodiesterase [Chelativorans sp. BNC1] Length = 647 Score = 431 bits (1108), Expect = e-118, Method: Compositional matrix adjust. Identities = 253/650 (38%), Positives = 363/650 (55%), Gaps = 32/650 (4%) Query: 18 APAAQLSLQQLIRADQLAALRQTVLLSIPVNMVLGAICTFVAWRAGHLAIALL-WLACSG 76 AP L+ IRADQL +R+ + S P++ +L A+ AGH +A+L W Sbjct: 9 APLRPEVLKLRIRADQLNDIRRGIFFSNPISSLLSALILAAHVAAGHAFVAVLVWFLAIN 68 Query: 77 MVNLLRILACRLPVQRVAALVQRIAAPGAGVIDLN-----LRVHWMLALCSGLVWAGVAL 131 +N RI+ C R++ G DL+ L +LA SG+ WA +AL Sbjct: 69 AINGARII-CAFRQSRISK---------QGCEDLSKVMAHLGQFKLLAFLSGINWAFLAL 118 Query: 132 LCAGYTAPGTLFYLTCVCGITAGAVTHGFAYARIPIAFITPPLLAIIASLVLVEPDTTRV 191 L GYT P + L + G++AGAV +G YA I I+F+ PPLL +IA L + Sbjct: 119 LTEGYTTPKSELDLIILAGVSAGAVVYGAPYAVISISFMLPPLLVVIACF-LYQGGFESY 177 Query: 192 ALAAAVLLYLGALIRGSKVSEGLVSHASALKNEATTASQALEVAHRDLHQFAERMRYQAE 251 + AV L++ LIRG+ V + S LK+EA Q A M + Sbjct: 178 LMVLAVALFIAGLIRGAMVGQARFLEGSRLKHEA--------------RQIAAEMEQSSR 223 Query: 252 HDLLTGLLGRAGFMAAAQAMAARREEVLCMMFLDLDGFKVINDAYGHDAGDQVLVEVARR 311 D L+GLL R G A + +A + M +DLDGFK +ND YGH GD +LV +A R Sbjct: 224 EDPLSGLLNRRGLEHAIEGLA-ETDGPFVTMLIDLDGFKSVNDTYGHKIGDDLLVRIAHR 282 Query: 312 LQGCLPAGATLARLGGDEFVILYALDAQAELPELLARRLIEVVRQPFARLAHRHIGLSLG 371 + P GA L+R+GGDEFV+LY A P LA LI + P+ +A IG +G Sbjct: 283 VGESAPPGAILSRIGGDEFVLLYPERAAPHPPGQLALDLIAAIASPYFLVASVRIGACIG 342 Query: 372 ITLSDRDDIDEMLVCSDAAMYQAKRRGRNQFCVFNETLNAHLQMKRDVERDLAGALARRE 431 I S + + EML+ +D A+Y AK RGRN+FC F+E L L+ ++ +ERDL A+ + E Sbjct: 343 IYRSQKPSLTEMLLRADIALYAAKGRGRNEFCEFDENLQQELERRQCIERDLIIAIEQGE 402 Query: 432 LAVWFQPIVQHDGQTLDGFEALLRWQHGKHGAIAAPDLIEIAALAGLSEELLRFILEEVA 491 L +WFQPIV + GFEALLRW+H HG I+ P++++ A GL +L + Sbjct: 403 LGIWFQPIVTLKTAEIVGFEALLRWRHPTHGEISPPEIVDAARETGLLFQLTETVFRNCC 462 Query: 492 GMIAFLQSSGRSDLRISMNISPREMERLVVDELVVSMLKAHRLPARMLEIEITEETALDL 551 M+ L+ +GRSD+R++MN SPRE+E VDE++++ L LP M EIEITEE ALD Sbjct: 463 VMMELLKKAGRSDIRVAMNFSPRELENSSVDEMIMTGLTERDLPVSMFEIEITEEAALDR 522 Query: 552 QAATQTLVALALQGVRIAIDDFGVGYSSLGFLRQMQVSRVKIDRSFVTGLADQTENQALV 611 + L L+ G+ IA+DDFG G+S+L L+ +++ +VKID+ F+ G+A ++Q LV Sbjct: 523 YRVHERLGRLSGFGISIALDDFGTGFSTLASLKDIRIRKVKIDKEFICGIAKSRDDQLLV 582 Query: 612 SAVLQLAGSFGFQVVAEGVESAEDLQTLQAMHCHAMQGYYFAPPMPAAQA 661 AV+ L +F +V+AEGVE+ ED + LQ + C QG+ FA +P +A Sbjct: 583 KAVIDLGRAFDIEVMAEGVETEEDRRVLQVLGCCTAQGFLFARALPINEA 632 >ref|ZP_04681986.1| diguanylate cyclase (GGDEF) domain-containing protein [Ochrobactrum intermedium LMG 3301] gb|EEQ93290.1| diguanylate cyclase (GGDEF) domain-containing protein [Ochrobactrum intermedium LMG 3301] Length = 687 Score = 411 bits (1057), Expect = e-112, Method: Compositional matrix adjust. Identities = 236/631 (37%), Positives = 355/631 (56%), Gaps = 26/631 (4%) Query: 29 IRADQLAALRQTVLLSIPVNMVLGAICTFVAWRAGHLAIALLWLACSGMVNLLRILACRL 88 I ADQL + + S+P++ +L + V AGH +++W A +VN LR Sbjct: 59 ILADQLGEICEGARFSMPISTILSVLIVLVQSAAGHFWESIVWFALVNIVNALRFFE--- 115 Query: 89 PVQRVAALVQRIAAPGAGVIDLN--LRVHWMLALCSGLVWAGVALLCAGYTAPGTLFYLT 146 A R AP V DL +R LA SG W+GVA+L +G+T P + YL Sbjct: 116 -----AIAYSRRLAPIENVADLQRQIRRFQFLAALSGFFWSGVAVLSSGFTDPQSPVYLV 170 Query: 147 CVCGITAGAVTHGFAYARIPIAFITPPLLAIIASLVLVEPDTTRVALAAAVLLYLGALIR 206 + GI AGAVT+G +YA I I FITPPL+ + L V+ D R +A +V+L+ L R Sbjct: 171 ILAGICAGAVTYGSSYASIAINFITPPLVVTVICLA-VQADLQRGVIAVSVVLFWCGLTR 229 Query: 207 GSKVSEGLVSHASALKNEATTASQALEVAHRDLHQFAERMRYQAEHDLLTGLLGRAGFMA 266 G+ + + S LK+EA Q A+ M +++ D LTGL R G Sbjct: 230 GALLGQNRFIQTSRLKHEA--------------KQLADEMALKSQEDPLTGLFNRRGLEN 275 Query: 267 AAQAMAARREEVLCMMFLDLDGFKVINDAYGHDAGDQVLVEVARRLQGCLPAGATLARLG 326 + + E +M +DLDGFK +ND YGH GD +LV +A+R++ P + LAR+G Sbjct: 276 SIRLFPVA-EGPFIVMLIDLDGFKSVNDTYGHKVGDDLLVAIAQRIRQISPERSVLARIG 334 Query: 327 GDEFVILYALDAQAELPELLARRLIEVVRQPFARLAHRHIGLSLGITLSDRDDIDEMLVC 386 GDEFV++Y + L+A R+I + + + IG +GI +R D EML+ Sbjct: 335 GDEFVLVYPEPSATIEAGLVAARIIGSLSAHYEGILSVEIGACVGICRLERLDPVEMLLR 394 Query: 387 SDAAMYQAKRRGRNQFCVFNETLNAHLQMKRDVERDLAGALARRELAVWFQPIVQHDGQT 446 +D A+Y AKRRGRN++ F + L+ + K+ +ERDL A+ ++ +FQP+V+ + Sbjct: 395 ADFALYAAKRRGRNEYYFFEKRLHHEWERKQSIERDLRIAIETGQIQTYFQPVVELSSGS 454 Query: 447 LDGFEALLRWQHGKHGAIAAPDLIEIAALAGLSEELLRFILEEVAGMIAFLQSSGRSDLR 506 + GFEALLRW H +HG IA P++I++A G+ +L + + MI L SGR DL Sbjct: 455 MVGFEALLRWDHPQHGTIAPPEIIDVACEVGVVRQLTKNVFFNCCEMIDKLTESGRCDLT 514 Query: 507 ISMNISPREMERLVVDELVVSMLKAHRLPARMLEIEITEETALDLQAATQTLVALALQGV 566 ++MN+SPREM + ++S ++ LP MLEIEITEE D + +L AL+ GV Sbjct: 515 VAMNLSPREMAGGRIPHEILSQMERRDLPVSMLEIEITEEAPFDQRGMNDSLDALSNAGV 574 Query: 567 RIAIDDFGVGYSSLGFLRQMQVSRVKIDRSFVTGLADQTENQALVSAVLQLAGSFGFQVV 626 IA+DDFG G+++ L++ + ++KID+ FV G+A+ +Q +V A++ LA + G +V Sbjct: 575 SIALDDFGTGFATFASLKKGLIDKIKIDQVFVRGIAESEGDQHIVRAMVALADALGVKVT 634 Query: 627 AEGVESAEDLQTLQAMHCHAMQGYYFAPPMP 657 AEG+E+ ED L A+ C + QG+ FAP +P Sbjct: 635 AEGIETEEDRDMLCALGCSSGQGFLFAPALP 665 >ref|YP_001371884.1| diguanylate cyclase/phosphodiesterase [Ochrobactrum anthropi ATCC 49188] gb|ABS16055.1| diguanylate cyclase/phosphodiesterase [Ochrobactrum anthropi ATCC 49188] Length = 656 Score = 399 bits (1024), Expect = e-108, Method: Compositional matrix adjust. Identities = 230/643 (35%), Positives = 364/643 (56%), Gaps = 24/643 (3%) Query: 29 IRADQLAALRQTVLLSIPVNMVLGAICTFVAWRAGHLAIALLWLACSGMVNLLRILACRL 88 I ADQL + S+P++ +L + V AGH + ++W A ++N LR++ Sbjct: 27 ILADQLREICDGARFSMPISTILSVLILLVQIAAGHFWMPIIWFALVNIINALRLIDAIA 86 Query: 89 PVQRVAALVQRIAAPGAGVIDLNLRVHWMLALCSGLVWAGVALLCAGYTAPGTLFYLTCV 148 + AA V+ IA V+ L + +G VWAGVA+L G++ P + YL + Sbjct: 87 YYRSPAAPVENIA-----VLQRQLARFQLFGALAGFVWAGVAILSHGFSDPQSSVYLVIL 141 Query: 149 CGITAGAVTHGFAYARIPIAFITPPLLAIIASLVLVEPDTTRVALAAAVLLYLGALIRGS 208 GI AGAVT+G +YA + I FITPPL+ ++++ D +A AV+L+ L RG+ Sbjct: 142 AGICAGAVTYGSSYAAVAINFITPPLVVT-VVCLVLQADLQYGVIAVAVVLFWLGLTRGA 200 Query: 209 KVSEGLVSHASALKNEATTASQALEVAHRDLHQFAERMRYQAEHDLLTGLLGRAGFMAAA 268 + + S LK+EA Q A+ M +++ D LTGL R G + Sbjct: 201 LLGQNRFIQTSRLKHEA--------------KQLADEMALKSQEDPLTGLFNRRGLETSI 246 Query: 269 QAMAARREEVLCMMFLDLDGFKVINDAYGHDAGDQVLVEVARRLQGCLPAGATLARLGGD 328 + + ++ +M +DLDGFK +ND YGH GD +LV +A+R++ P + LAR+GGD Sbjct: 247 R-LYPVKDGPFIVMLIDLDGFKSVNDTYGHKVGDDLLVAIAQRIRQVSPERSVLARIGGD 305 Query: 329 EFVILYALDAQAELPELLARRLIEVVRQPFARLAHRHIGLSLGITLSDRDDIDEMLVCSD 388 EFV+ Y + L+A R+I + + + IG +GI +R D EML+ +D Sbjct: 306 EFVLAYPEPSAKIEAGLVAARIIGSLTAHYEGILSVEIGACVGICRLERLDPVEMLLRAD 365 Query: 389 AAMYQAKRRGRNQFCVFNETLNAHLQMKRDVERDLAGALARRELAVWFQPIVQHDGQTLD 448 A+Y AK+RGRN++ F + L + K+ +ERDL A+ ++ +FQP+VQ + Sbjct: 366 FALYAAKKRGRNEYYFFEKRLQHEWERKQSIERDLRIAIETGQVQTYFQPVVQLSSGRMV 425 Query: 449 GFEALLRWQHGKHGAIAAPDLIEIAALAGLSEELLRFILEEVAGMIAFLQSSGRSDLRIS 508 GFEALLRW H +HG I P++I++A G+ +L +L MI L GRSDL ++ Sbjct: 426 GFEALLRWDHPQHGTIPPPEIIDVACEVGVVRQLTNNVLFNCCEMIDKLTEGGRSDLTVA 485 Query: 509 MNISPREMERLVVDELVVSMLKAHRLPARMLEIEITEETALDLQAATQTLVALALQGVRI 568 MN+SPRE+ + ++S ++ LP MLEIEITEE D + + +L L+ GV I Sbjct: 486 MNLSPRELAGGRIPHEILSQMEKRELPMSMLEIEITEEAPFDQRGMSDSLGVLSSAGVSI 545 Query: 569 AIDDFGVGYSSLGFLRQMQVSRVKIDRSFVTGLADQTENQALVSAVLQLAGSFGFQVVAE 628 A+DDFG G+++ L++ ++++KID+ FV G+A+ +Q +V A+++L + G +V AE Sbjct: 546 ALDDFGTGFATFASLKKGLITKIKIDKVFVRGIAESEGDQHIVRAMVELGDALGIKVTAE 605 Query: 629 GVESAEDLQTLQAMHCHAMQGYYFAPPMPAAQARARIEALAQA 671 G+E+ ED L + C+A QG+ F+P +PA+ A ++ALA+A Sbjct: 606 GIETEEDRDMLCKLGCNAGQGFLFSPALPASMA---LDALAKA 645 >ref|ZP_00051942.2| COG5001: Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Magnetospirillum magnetotacticum MS-1] Length = 381 Score = 343 bits (880), Expect = 6e-92, Method: Compositional matrix adjust. Identities = 179/370 (48%), Positives = 245/370 (66%) Query: 301 GDQVLVEVARRLQGCLPAGATLARLGGDEFVILYALDAQAELPELLARRLIEVVRQPFAR 360 GD+VL+EVA+R++ LPA +ARLGGDEF +++ E P LA RLI V +PF Sbjct: 2 GDRVLIEVAQRIRTTLPAECDIARLGGDEFAVVFDRTQVIENPAALAERLIRAVAEPFDS 61 Query: 361 LAHRHIGLSLGITLSDRDDIDEMLVCSDAAMYQAKRRGRNQFCVFNETLNAHLQMKRDVE 420 +G+S+GI + + ++L C+D A+Y AK GRN F +F+E L L+M+R+ E Sbjct: 62 FDAGRLGMSVGICHRPAESLTQLLSCADEALYAAKHTGRNHFRLFDEGLRKRLEMRRECE 121 Query: 421 RDLAGALARRELAVWFQPIVQHDGQTLDGFEALLRWQHGKHGAIAAPDLIEIAALAGLSE 480 R L+ ALA L VWFQPI G++ EAL+RW H HG ++ PDLI AA+AGL+E Sbjct: 122 RGLSQALAEGALKVWFQPIFGCGGRSATSLEALVRWHHPVHGWVSPPDLIAAAAMAGLTE 181 Query: 481 ELLRFILEEVAGMIAFLQSSGRSDLRISMNISPREMERLVVDELVVSMLKAHRLPARMLE 540 LLRFILE+V M+ L+S G L ++MN+SPREM ++ VDE+++ L+A LP +LE Sbjct: 182 SLLRFILEQVCTMLCALRSRGFHTLSVAMNVSPREMAQIPVDEIILGRLRALGLPTTVLE 241 Query: 541 IEITEETALDLQAATQTLVALALQGVRIAIDDFGVGYSSLGFLRQMQVSRVKIDRSFVTG 600 IEITEETALD++A L+AL+ G+R+A+DDFG GYSSL LRQ++ RVKI RS VTG Sbjct: 242 IEITEETALDIEAVQGKLLALSRAGIRVALDDFGNGYSSLASLRQLRADRVKIHRSLVTG 301 Query: 601 LADQTENQALVSAVLQLAGSFGFQVVAEGVESAEDLQTLQAMHCHAMQGYYFAPPMPAAQ 660 L + + + LV AVL L + +VVAEG+E+A+DL TLQAM C MQG++ P PA Sbjct: 302 LTEAEDKRELVQAVLGLGRALDLEVVAEGIETADDLATLQAMGCPFMQGFHLGRPQPADD 361 Query: 661 ARARIEALAQ 670 +E L+ Sbjct: 362 ILDSLETLSD 371