BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0006.0036.p (164 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003776838.1| dihydrofolate reductase oxidoreductase [Herb... 338 2e-91 ref|YP_001099361.1| dihydrofolate reductase [Herminiimonas arsen... 252 1e-65 ref|YP_001352882.1| dihydrofolate reductase [Janthinobacterium s... 251 2e-65 ref|YP_004752083.1| dihydrofolate reductase [Collimonas fungivor... 238 2e-61 ref|ZP_08274137.1| Dihydrofolate reductase [Oxalobacteraceae bac... 227 4e-58 ref|YP_727151.1| dihydrofolate reductase [Ralstonia eutropha H16... 212 1e-53 ref|YP_004686399.1| dihydrofolate reductase FolA [Cupriavidus ne... 212 2e-53 ref|YP_295137.1| dihydrofolate reductase [Ralstonia eutropha JMP... 211 2e-53 ref|YP_584715.1| dihydrofolate reductase [Cupriavidus metallidur... 211 2e-53 ref|YP_002006193.1| dihydrofolate reductase type I [Cupriavidus ... 204 3e-51 >ref|YP_003776838.1| dihydrofolate reductase oxidoreductase [Herbaspirillum seropedicae SmR1] gb|ADJ64930.1| dihydrofolate reductase oxidoreductase protein [Herbaspirillum seropedicae SmR1] Length = 164 Score = 338 bits (866), Expect = 2e-91, Method: Compositional matrix adjust. Identities = 163/164 (99%), Positives = 163/164 (99%) Query: 1 MTISSGQLTLIVATDLNNGIGINNTLPWRLPEDLAHFKRTTSGHAILMGRKTFDSIGRPL 60 MT SSGQLTLIVATDLNNGIGINNTLPWRLPEDLAHFKRTTSGHAILMGRKTFDSIGRPL Sbjct: 1 MTTSSGQLTLIVATDLNNGIGINNTLPWRLPEDLAHFKRTTSGHAILMGRKTFDSIGRPL 60 Query: 61 PNRRNIVITRNAGWQHDGVETAGSLQEAAALCAGAPAFIIGGAQIYAEALPLADRLIITR 120 PNRRNIVITRNAGWQHDGVETAGSLQEAAALCAGAPAFIIGGAQIYAEALPLADRLIITR Sbjct: 61 PNRRNIVITRNAGWQHDGVETAGSLQEAAALCAGAPAFIIGGAQIYAEALPLADRLIITR 120 Query: 121 IAQTFDCDAFFPALDQQVWQETAREEHHSETSGLDYAFVTYERR 164 IAQTFDCDAFFPALDQQVWQETAREEHHSETSGLDYAFVTYERR Sbjct: 121 IAQTFDCDAFFPALDQQVWQETAREEHHSETSGLDYAFVTYERR 164 >ref|YP_001099361.1| dihydrofolate reductase [Herminiimonas arsenicoxydans] emb|CAL61234.1| dihydrofolate reductase [Herminiimonas arsenicoxydans] Length = 162 Score = 252 bits (644), Expect = 1e-65, Method: Compositional matrix adjust. Identities = 116/158 (73%), Positives = 132/158 (83%) Query: 6 GQLTLIVATDLNNGIGINNTLPWRLPEDLAHFKRTTSGHAILMGRKTFDSIGRPLPNRRN 65 LT++VA D NNGIGINNTLPW LPEDLAHFKRTTSGH I+MGRKTFDSIGRPLPNRRN Sbjct: 3 AHLTIVVAIDTNNGIGINNTLPWHLPEDLAHFKRTTSGHPIIMGRKTFDSIGRPLPNRRN 62 Query: 66 IVITRNAGWQHDGVETAGSLQEAAALCAGAPAFIIGGAQIYAEALPLADRLIITRIAQTF 125 IVITRN WQH GVET SL A AL G PAFIIGG QI+A+ L ++RLI+TRI +TF Sbjct: 63 IVITRNTEWQHAGVETVTSLAAAKALVDGTPAFIIGGGQIFADTLADSNRLIVTRIDKTF 122 Query: 126 DCDAFFPALDQQVWQETAREEHHSETSGLDYAFVTYER 163 DCDAFFPA+D + WQETAREEHHSE +G D+A++TY+R Sbjct: 123 DCDAFFPAIDPRQWQETAREEHHSEVNGFDFAYITYDR 160 >ref|YP_001352882.1| dihydrofolate reductase [Janthinobacterium sp. Marseille] gb|ABR88509.1| dihydrofolate reductase [Janthinobacterium sp. Marseille] Length = 162 Score = 251 bits (642), Expect = 2e-65, Method: Compositional matrix adjust. Identities = 116/158 (73%), Positives = 131/158 (82%) Query: 6 GQLTLIVATDLNNGIGINNTLPWRLPEDLAHFKRTTSGHAILMGRKTFDSIGRPLPNRRN 65 LT++VATD NNGIGINNTLPW LPEDLAHFKRTTSGH I+MGRKTFDSIGRPLPNRRN Sbjct: 3 AHLTIVVATDSNNGIGINNTLPWHLPEDLAHFKRTTSGHPIIMGRKTFDSIGRPLPNRRN 62 Query: 66 IVITRNAGWQHDGVETAGSLQEAAALCAGAPAFIIGGAQIYAEALPLADRLIITRIAQTF 125 IVITRNA WQH GVE SL A AL AFIIGGAQIY + + DRLI+T+I ++F Sbjct: 63 IVITRNAEWQHAGVEAVTSLDSAKALVGDNQAFIIGGAQIYTDTVGQVDRLIVTKIDKSF 122 Query: 126 DCDAFFPALDQQVWQETAREEHHSETSGLDYAFVTYER 163 DCDAFFPA+D ++WQETARE+HHSE +G DYA+VTYER Sbjct: 123 DCDAFFPAIDPKLWQETAREQHHSEANGYDYAYVTYER 160 >ref|YP_004752083.1| dihydrofolate reductase [Collimonas fungivorans Ter331] gb|AEK61260.1| Dihydrofolate reductase [Collimonas fungivorans Ter331] Length = 170 Score = 238 bits (608), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 112/157 (71%), Positives = 125/157 (79%) Query: 7 QLTLIVATDLNNGIGINNTLPWRLPEDLAHFKRTTSGHAILMGRKTFDSIGRPLPNRRNI 66 +LT+IVATD NGIGI NTLPW LPEDLAHFKRTTSGH I+MGRKTF+SIGRPLP RRNI Sbjct: 4 RLTIIVATDARNGIGIRNTLPWHLPEDLAHFKRTTSGHPIIMGRKTFESIGRPLPQRRNI 63 Query: 67 VITRNAGWQHDGVETAGSLQEAAALCAGAPAFIIGGAQIYAEALPLADRLIITRIAQTFD 126 VITRN GW+HDGVE+A SL AA + A AFIIGGA+IYA A L RLI+T I +FD Sbjct: 64 VITRNPGWRHDGVESAPSLAAAAVMVGDAEAFIIGGAEIYAAAQDLTQRLIVTEIQHSFD 123 Query: 127 CDAFFPALDQQVWQETAREEHHSETSGLDYAFVTYER 163 CDAFFPA D WQE +RE HHSE +G DYAFV Y+R Sbjct: 124 CDAFFPARDPSQWQEISRETHHSEANGFDYAFVVYQR 160 >ref|ZP_08274137.1| Dihydrofolate reductase [Oxalobacteraceae bacterium IMCC9480] gb|EGF32394.1| Dihydrofolate reductase [Oxalobacteraceae bacterium IMCC9480] Length = 162 Score = 227 bits (579), Expect = 4e-58, Method: Compositional matrix adjust. Identities = 107/157 (68%), Positives = 124/157 (78%) Query: 8 LTLIVATDLNNGIGINNTLPWRLPEDLAHFKRTTSGHAILMGRKTFDSIGRPLPNRRNIV 67 LTLIVA D GIGI NT+PW+LPEDLAHFKRTT+GH ILMGRKTF+SIGRPLPNRRNIV Sbjct: 4 LTLIVAIDNAGGIGIRNTMPWKLPEDLAHFKRTTTGHPILMGRKTFESIGRPLPNRRNIV 63 Query: 68 ITRNAGWQHDGVETAGSLQEAAALCAGAPAFIIGGAQIYAEALPLADRLIITRIAQTFDC 127 I+RN W+H+GVET SLQ A L A F+IGGA+IY ALPLADRLI+T I Q F+C Sbjct: 64 ISRNPDWRHEGVETVASLQAALDLPEAAEVFVIGGAEIYRLALPLADRLIVTEIKQRFEC 123 Query: 128 DAFFPALDQQVWQETAREEHHSETSGLDYAFVTYERR 164 DAFFP +D W TARE H S ++G D+AFVTY+R+ Sbjct: 124 DAFFPTIDPAEWIATAREPHQSISNGFDFAFVTYQRQ 160 >ref|YP_727151.1| dihydrofolate reductase [Ralstonia eutropha H16] emb|CAJ93783.1| dihydrofolate reductase [Ralstonia eutropha H16] Length = 166 Score = 212 bits (540), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 102/157 (64%), Positives = 122/157 (77%), Gaps = 1/157 (0%) Query: 8 LTLIVATDLNNGIGINNTLPWRLPEDLAHFKRTTSGHAILMGRKTFDSIGRPLPNRRNIV 67 LTL+VA NN IG +NTLPWRLPEDLAHFKRTT G ++MGRKT+DSIGRPLP RRNIV Sbjct: 4 LTLVVARARNNTIGRDNTLPWRLPEDLAHFKRTTMGAPVIMGRKTWDSIGRPLPGRRNIV 63 Query: 68 ITRNAGWQHDGVETAGSLQEAAALCAGAPA-FIIGGAQIYAEALPLADRLIITRIAQTFD 126 ++RN + +G E A SL++A LC GA F+IGGAQ+YAEA+P ADRL++T I + Sbjct: 64 VSRNPDLRIEGAEVAASLEDAQRLCVGAEQIFLIGGAQLYAEAMPCADRLVVTEIDADVE 123 Query: 127 CDAFFPALDQQVWQETAREEHHSETSGLDYAFVTYER 163 DAFFPA+D+ W ETARE HHSE +G DYAFVTYER Sbjct: 124 GDAFFPAIDRTQWVETARETHHSEANGFDYAFVTYER 160 >ref|YP_004686399.1| dihydrofolate reductase FolA [Cupriavidus necator N-1] gb|AEI77918.1| dihydrofolate reductase FolA [Cupriavidus necator N-1] Length = 166 Score = 212 bits (539), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 102/157 (64%), Positives = 122/157 (77%), Gaps = 1/157 (0%) Query: 8 LTLIVATDLNNGIGINNTLPWRLPEDLAHFKRTTSGHAILMGRKTFDSIGRPLPNRRNIV 67 LTL+VA NN IG +NTLPWRLPEDLAHFKRTT G ++MGRKT+DSIGRPLP RRNIV Sbjct: 4 LTLVVARARNNTIGRDNTLPWRLPEDLAHFKRTTMGAPVIMGRKTWDSIGRPLPGRRNIV 63 Query: 68 ITRNAGWQHDGVETAGSLQEAAALCAGAPA-FIIGGAQIYAEALPLADRLIITRIAQTFD 126 ++RN + +G E A SL++A LC GA F+IGGAQ+YAEA+P ADRL++T I + Sbjct: 64 VSRNPDLRIEGAEVAASLEDAQRLCVGAEQIFLIGGAQLYAEAMPSADRLVVTEIDADVE 123 Query: 127 CDAFFPALDQQVWQETAREEHHSETSGLDYAFVTYER 163 DAFFPA+D+ W ETARE HHSE +G DYAFVTYER Sbjct: 124 GDAFFPAIDRTQWIETARETHHSEANGFDYAFVTYER 160 >ref|YP_295137.1| dihydrofolate reductase [Ralstonia eutropha JMP134] gb|AAZ60293.1| dihydrofolate reductase [Ralstonia eutropha JMP134] Length = 166 Score = 211 bits (538), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 103/157 (65%), Positives = 120/157 (76%), Gaps = 1/157 (0%) Query: 8 LTLIVATDLNNGIGINNTLPWRLPEDLAHFKRTTSGHAILMGRKTFDSIGRPLPNRRNIV 67 LTL+VA N IG NNTLPWRLPEDLAHFKRTT G I+MGRKT+DSIGRPLP RRNIV Sbjct: 4 LTLVVARARNGTIGRNNTLPWRLPEDLAHFKRTTMGAPIIMGRKTWDSIGRPLPGRRNIV 63 Query: 68 ITRNAGWQHDGVETAGSLQEAAALCAGAP-AFIIGGAQIYAEALPLADRLIITRIAQTFD 126 ++RNA + G E A SL++A LC G F+IGGAQ+YAEALP ADRL++T I + Sbjct: 64 VSRNADLKLQGAEVATSLEDAQRLCVGVEQVFLIGGAQLYAEALPSADRLVVTEIDADVE 123 Query: 127 CDAFFPALDQQVWQETAREEHHSETSGLDYAFVTYER 163 DAFFPA+DQ W ET+RE HHSE +G DYAFVTY+R Sbjct: 124 GDAFFPAIDQAKWIETSRETHHSEANGFDYAFVTYDR 160 >ref|YP_584715.1| dihydrofolate reductase [Cupriavidus metallidurans CH34] gb|ABF09446.1| dihydrofolate reductase [Cupriavidus metallidurans CH34] Length = 166 Score = 211 bits (538), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 105/157 (66%), Positives = 120/157 (76%), Gaps = 1/157 (0%) Query: 8 LTLIVATDLNNGIGINNTLPWRLPEDLAHFKRTTSGHAILMGRKTFDSIGRPLPNRRNIV 67 LTLIVA N IG NNTLPWRLPEDL HFKRTT G I+MGRKT+DSIGRPLP RRNIV Sbjct: 4 LTLIVARARNGVIGRNNTLPWRLPEDLQHFKRTTMGAPIIMGRKTWDSIGRPLPGRRNIV 63 Query: 68 ITRNAGWQHDGVETAGSLQEAAALCAGAP-AFIIGGAQIYAEALPLADRLIITRIAQTFD 126 +TRN +G + GS+++A LC GA F+IGGAQ+YAEALP ADRLI+T I + Sbjct: 64 VTRNRDLHIEGADVVGSIEDAQRLCIGAEQVFLIGGAQLYAEALPSADRLIVTEIDADVE 123 Query: 127 CDAFFPALDQQVWQETAREEHHSETSGLDYAFVTYER 163 DAFFPA+D+ W ETARE HHSET+G DYAFVTYER Sbjct: 124 GDAFFPAVDRTTWVETARELHHSETNGFDYAFVTYER 160 >ref|YP_002006193.1| dihydrofolate reductase type I [Cupriavidus taiwanensis LMG 19424] emb|CAQ70130.1| dihydrofolate reductase type I [Cupriavidus taiwanensis LMG 19424] Length = 166 Score = 204 bits (520), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 99/157 (63%), Positives = 119/157 (75%), Gaps = 1/157 (0%) Query: 8 LTLIVATDLNNGIGINNTLPWRLPEDLAHFKRTTSGHAILMGRKTFDSIGRPLPNRRNIV 67 LTL+VA N IG +NTLPWRLPEDLAHFKRTT G ++MGRKT+DSIGRPLP RRNIV Sbjct: 4 LTLVVARARNGTIGRDNTLPWRLPEDLAHFKRTTMGAPVIMGRKTWDSIGRPLPGRRNIV 63 Query: 68 ITRNAGWQHDGVETAGSLQEAAALCAGAPA-FIIGGAQIYAEALPLADRLIITRIAQTFD 126 ++RN + +G E A SL++A LC GA F+IGGAQ+YAEA+P ADRL++T I + Sbjct: 64 VSRNPDLRLEGAEVAPSLEDAQRLCVGAEQIFLIGGAQLYAEAMPSADRLVVTEIDADVE 123 Query: 127 CDAFFPALDQQVWQETAREEHHSETSGLDYAFVTYER 163 DAFFP +D+ W ETARE HHS +G DYAFVTYER Sbjct: 124 GDAFFPEIDRTQWIETARETHHSAANGFDYAFVTYER 160