BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0006.0017.p         (567 letters)

Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects 
           15,459,386 sequences; 5,307,515,862 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

ref|YP_003776820.1| 2-isopropylmalate synthase [Herbaspirillum s...  1169   0.0  
ref|YP_004752177.1| 2-isopropylmalate synthase [Collimonas fungi...   973   0.0  
ref|YP_001352888.1| 2-isopropylmalate synthase [Janthinobacteriu...   885   0.0  
emb|CAL61215.2| 2-isopropylmalate synthase (Alpha-isopropylmalat...   874   0.0  
ref|YP_728252.1| 2-isopropylmalate synthase [Ralstonia eutropha ...   854   0.0  
ref|YP_001796513.1| 2-isopropylmalate synthase [Cupriavidus taiw...   844   0.0  
ref|YP_004680290.1| 2-isopropylmalate synthase LeuA [Cupriavidus...   844   0.0  
ref|YP_004418226.1| 2-isopropylmalate synthase [Pusillimonas sp....   829   0.0  
ref|YP_001628685.1| 2-isopropylmalate synthase [Bordetella petri...   829   0.0  
gb|EFV84760.1| 2-isopropylmalate synthase [Achromobacter xylosox...   829   0.0  

>ref|YP_003776820.1| 2-isopropylmalate synthase [Herbaspirillum seropedicae SmR1]
 gb|ADJ64912.1| 2-isopropylmalate synthase protein [Herbaspirillum seropedicae
           SmR1]
          Length = 567

 Score = 1169 bits (3025), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 566/567 (99%), Positives = 567/567 (100%)

Query: 1   MMLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFE 60
           MMLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFE
Sbjct: 1   MMLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFE 60

Query: 61  LLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESLEG 120
           LLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSR+ELIRRTIESLEG
Sbjct: 61  LLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSREELIRRTIESLEG 120

Query: 121 AKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESF 180
           AKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESF
Sbjct: 121 AKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESF 180

Query: 181 STTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRAST 240
           STTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRAST
Sbjct: 181 STTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRAST 240

Query: 241 IISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGL 300
           IISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGL
Sbjct: 241 IISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGL 300

Query: 301 DFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPY 360
           DFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPY
Sbjct: 301 DFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPY 360

Query: 361 LPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGK 420
           LPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGK
Sbjct: 361 LPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGK 420

Query: 421 EIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNG 480
           EIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNG
Sbjct: 421 EIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNG 480

Query: 481 PIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFK 540
           PIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFK
Sbjct: 481 PIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFK 540

Query: 541 AVLSAVNRQIAISESANQAGSSQAKAA 567
           AVLSAVNRQIAISESANQAGSSQAKAA
Sbjct: 541 AVLSAVNRQIAISESANQAGSSQAKAA 567


>ref|YP_004752177.1| 2-isopropylmalate synthase [Collimonas fungivorans Ter331]
 gb|AEK61354.1| 2-isopropylmalate synthase [Collimonas fungivorans Ter331]
          Length = 568

 Score =  973 bits (2516), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 463/568 (81%), Positives = 516/568 (90%), Gaps = 1/568 (0%)

Query: 1   MMLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFE 60
           MML NPA KYRPFP I L DRTWP++VI+ PPIWMSTDLRDGNQALIEPM+A+RKLRFF+
Sbjct: 1   MMLHNPAVKYRPFPPIPLSDRTWPNQVISAPPIWMSTDLRDGNQALIEPMDADRKLRFFK 60

Query: 61  LLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESLEG 120
           LL+K GLKEIEVGFPS SQTDFDFVRKLI EN IPDDVTIIVLTQSR++LIRRT++SL+ 
Sbjct: 61  LLVKIGLKEIEVGFPSGSQTDFDFVRKLIEENHIPDDVTIIVLTQSREDLIRRTVDSLQN 120

Query: 121 AKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESF 180
           AK+AIVHLYN +APA+R+IVF+ SR+E+K IAV+GTRL+KELTDARP T+WR+EYSPE+F
Sbjct: 121 AKQAIVHLYNPIAPAWRRIVFDKSRDEVKEIAVSGTRLIKELTDARPETQWRYEYSPETF 180

Query: 181 STTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRAST 240
           S  ELDFSKE+CDAV E W ASP RKVILNLP+TVEC+TPNV+ADQIEWM RNL  R +T
Sbjct: 181 SMAELDFSKEVCDAVVEAWHASPTRKVILNLPTTVECSTPNVFADQIEWMHRNLARRDAT 240

Query: 241 IISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGL 300
           IISVHPHNDRGT VA+AELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGL
Sbjct: 241 IISVHPHNDRGTGVAAAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGL 300

Query: 301 DFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPY 360
           DFSDID VRQ VE+CNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFA Q+ DAIWE+PY
Sbjct: 301 DFSDIDEVRQCVEDCNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAAQKADAIWEIPY 360

Query: 361 LPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGK 420
           LPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLA+PRRLQIEFSRAIQ+ ADATGK
Sbjct: 361 LPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLAMPRRLQIEFSRAIQKAADATGK 420

Query: 421 EIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNG 480
           EIAASDI+ IF++EYL++  PYVYR HRMSEDSS+A+ + IE+DIVR+GQ  T  G GNG
Sbjct: 421 EIAASDIYNIFKQEYLDKQTPYVYRGHRMSEDSSQAQPVRIEIDIVRDGQAHTSSGHGNG 480

Query: 481 PIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFK 540
           PIDAFV+ALGLDIKLMDFHEHAI AGADA+AASYIELRLN+APTGFGVGIDAN +TASFK
Sbjct: 481 PIDAFVNALGLDIKLMDFHEHAISAGADAQAASYIELRLNDAPTGFGVGIDANTLTASFK 540

Query: 541 AVLSAVNRQIAIS-ESANQAGSSQAKAA 567
           A+LSAVNRQI I+ ++ANQ     A AA
Sbjct: 541 AILSAVNRQIEIAGQAANQEIGGNAAAA 568


>ref|YP_001352888.1| 2-isopropylmalate synthase [Janthinobacterium sp. Marseille]
 gb|ABR88384.1| 2-isopropylmalate synthase [Janthinobacterium sp. Marseille]
          Length = 552

 Score =  885 bits (2288), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 421/553 (76%), Positives = 488/553 (88%), Gaps = 2/553 (0%)

Query: 1   MMLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFE 60
           MML+NPAAKYR FP + L DRTWP++VI+TPPIWMSTDLRDGNQALIEPMN E+KLRFF+
Sbjct: 1   MMLTNPAAKYRAFPPVQLKDRTWPNRVISTPPIWMSTDLRDGNQALIEPMNHEKKLRFFD 60

Query: 61  LLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESLEG 120
           +LLK GLKEIEV FPSASQTDFDFVRKLI E RIPDDVTI VLTQ+R++LIRRT++S+ G
Sbjct: 61  MLLKIGLKEIEVAFPSASQTDFDFVRKLIDEKRIPDDVTIEVLTQAREDLIRRTVDSVVG 120

Query: 121 AKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESF 180
           +++AIVH+YN+ APAFR+IVFNMS+EE+K +AV GT+L++ELTDA P TEW F+YSPE+F
Sbjct: 121 SRRAIVHMYNATAPAFRRIVFNMSKEEVKALAVAGTKLIRELTDAHPETEWVFQYSPETF 180

Query: 181 STTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRAST 240
           S TELDF+KE+CDAV E W  +PERK+I+NLP TVE +TPNVYADQ+EWM RNL  R S 
Sbjct: 181 SMTELDFAKEVCDAVSEAWQPTPERKMIINLPGTVEASTPNVYADQVEWMHRNLARRDSI 240

Query: 241 IISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGL 300
           I+SVHPHNDRG AVA+AELAVMAGADR+EGCLFGNGERTGNVDLVTLALNLY+QG+NPGL
Sbjct: 241 ILSVHPHNDRGCAVAAAELAVMAGADRIEGCLFGNGERTGNVDLVTLALNLYSQGINPGL 300

Query: 301 DFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPY 360
           DFSDID +RQ VEECNQIPVHPRHPYVGDLV+TAFSGSHQDAIKKGFAKQ+PD IWEVPY
Sbjct: 301 DFSDIDEIRQCVEECNQIPVHPRHPYVGDLVYTAFSGSHQDAIKKGFAKQKPDEIWEVPY 360

Query: 361 LPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGK 420
           +P+DPADLGRSYDAVIRVNSQSGKGGM YLLEQEYGL LPRRLQIEFSRA+QR  D TG 
Sbjct: 361 MPVDPADLGRSYDAVIRVNSQSGKGGMTYLLEQEYGLVLPRRLQIEFSRAVQRITDETGG 420

Query: 421 EIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNG 480
           E+AA+DIH IF  EYL  V PY YR H +  D SK   + I+V++ ++G+PV+++G GNG
Sbjct: 421 EVAANDIHTIFNSEYLNAVTPYHYRNHHI--DDSKDGEVQIKVELEKDGKPVSMQGVGNG 478

Query: 481 PIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFK 540
           PIDAF++ALGL+IKLMDFHEHAIGAGA A AASY+ELR+N   T FGVGID NIVTASF+
Sbjct: 479 PIDAFINALGLNIKLMDFHEHAIGAGASANAASYVELRVNNGVTRFGVGIDGNIVTASFR 538

Query: 541 AVLSAVNRQIAIS 553
           AVLSAVNR IA++
Sbjct: 539 AVLSAVNRDIALA 551


>emb|CAL61215.2| 2-isopropylmalate synthase (Alpha-isopropylmalate synthase)
           (Alpha-IPM synthetase) [Herminiimonas arsenicoxydans]
          Length = 553

 Score =  874 bits (2257), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 416/553 (75%), Positives = 482/553 (87%), Gaps = 1/553 (0%)

Query: 1   MMLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFE 60
           MMLSNP  KYR FP + L DR WP++VI+  PIWMSTDLRDGNQ+LIEPMN ++KLRFF+
Sbjct: 1   MMLSNPEQKYRAFPPVRLTDRNWPNQVISKAPIWMSTDLRDGNQSLIEPMNHDKKLRFFD 60

Query: 61  LLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESLEG 120
           +L+K GLKEIEV FPSASQTDFDFVR+LI E RIPDDVTI VLT +R++LIRRT+ES+ G
Sbjct: 61  MLVKIGLKEIEVAFPSASQTDFDFVRRLIEEKRIPDDVTIEVLTPAREDLIRRTVESVVG 120

Query: 121 AKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESF 180
           A++AI+HLYN+ APAFR+IVFNMSR+E+K +AV G +LV+ELTDA P TEW F+YSPE+F
Sbjct: 121 ARRAIIHLYNATAPAFRRIVFNMSRDEVKALAVAGAKLVRELTDAHPETEWVFQYSPEAF 180

Query: 181 STTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRAST 240
           S TEL+FSKEICDAV  TW  +PERK+I NLP TVE +TPNVYADQ+EWM RNL  R S 
Sbjct: 181 SMTELEFSKEICDAVSATWQPTPERKMIFNLPGTVEASTPNVYADQVEWMHRNLARRDSI 240

Query: 241 IISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGL 300
           +ISVHPHNDRG AVA+AELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLY+QG++PGL
Sbjct: 241 LISVHPHNDRGCAVAAAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYSQGISPGL 300

Query: 301 DFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPY 360
           DFSDID VRQ VEECNQIPVHPRHPYVGDLV+TAFSGSHQDAIKKGFA+QQPDAIWEVPY
Sbjct: 301 DFSDIDAVRQCVEECNQIPVHPRHPYVGDLVYTAFSGSHQDAIKKGFAQQQPDAIWEVPY 360

Query: 361 LPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGK 420
           +P+DPADLGRSYDAVIRVNSQSGKGGM YLLEQEYGL LPRRLQIEFSRA+QR  D TG 
Sbjct: 361 MPVDPADLGRSYDAVIRVNSQSGKGGMTYLLEQEYGLVLPRRLQIEFSRAVQRITDETGG 420

Query: 421 EIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNG 480
           E+AA+DIH IF  EYL  V PY YR+H + E    AE + I V++ ++G+PVT++G+GNG
Sbjct: 421 EVAANDIHTIFNNEYLNAVTPYQYRSHHIDESQGNAE-VRIRVELEKDGKPVTLQGAGNG 479

Query: 481 PIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFK 540
           PIDAF++ALG+DI+LMDFHEHAIGAGA+A AASY+ELR+N   T FGVGID NIVTAS +
Sbjct: 480 PIDAFINALGMDIRLMDFHEHAIGAGANANAASYVELRVNNGSTRFGVGIDGNIVTASLR 539

Query: 541 AVLSAVNRQIAIS 553
           AVLSAVNR IA++
Sbjct: 540 AVLSAVNRDIALA 552


>ref|YP_728252.1| 2-isopropylmalate synthase [Ralstonia eutropha H16]
 emb|CAJ94887.1| 2-Isopropylmalate synthase [Ralstonia eutropha H16]
          Length = 565

 Score =  854 bits (2206), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 400/565 (70%), Positives = 467/565 (82%), Gaps = 2/565 (0%)

Query: 2   MLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFEL 61
           MLSNPA KY P   +D+PDRTWP++ I   P WMSTDLRDGNQALIEPMN  RKLRFFE 
Sbjct: 1   MLSNPATKYHPAATVDIPDRTWPARTITRAPRWMSTDLRDGNQALIEPMNPARKLRFFEQ 60

Query: 62  LLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESLEGA 121
           L+K GLKEIEV FP+ASQTDFDFVR LI E RIP+DV I+VLTQSR++LIRRT+ES+ GA
Sbjct: 61  LVKIGLKEIEVAFPAASQTDFDFVRMLIEEQRIPEDVNIVVLTQSREDLIRRTVESVRGA 120

Query: 122 KKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESFS 181
            +A VHLYN +APA+R+IVFN SREEIK +AV+GTRL++ LTDA PGT W +EYSPE+FS
Sbjct: 121 ARATVHLYNPIAPAWRRIVFNASREEIKEVAVSGTRLIRSLTDAMPGTAWAYEYSPETFS 180

Query: 182 TTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRASTI 241
             ELDFS E+ DAV   W A P+R +ILNLP+TVEC+TPNV+ADQ+EWM R L  R    
Sbjct: 181 LAELDFSLEVSDAVSAAWQAGPDRPMILNLPTTVECSTPNVFADQVEWMHRRLARREHIA 240

Query: 242 ISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGLD 301
           +SVHPHNDRGTAVA+AELA+MAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGV PGLD
Sbjct: 241 LSVHPHNDRGTAVAAAELALMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVAPGLD 300

Query: 302 FSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPYL 361
           FSDID VRQ VE CNQ+PVHPRHPYVGDLVFTAFSGSHQDAI+KGFA+QQPD IWEVPYL
Sbjct: 301 FSDIDAVRQCVEHCNQLPVHPRHPYVGDLVFTAFSGSHQDAIRKGFAQQQPDGIWEVPYL 360

Query: 362 PIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGKE 421
           PIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQ +G+ +PRRLQIEFSRA+Q   D TG E
Sbjct: 361 PIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQVHGIYMPRRLQIEFSRAVQAMTDDTGLE 420

Query: 422 IAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNGP 481
            +A D+H +FQREYL +  P  Y +H++  DS  A    IEV +VR+G+P +VRG+GNGP
Sbjct: 421 ASADDLHGLFQREYLAQQTPLRYVSHQLVSDSGGA--TEIEVQMVRDGKPCSVRGTGNGP 478

Query: 482 IDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFKA 541
           IDAFV+AL L +++MD+HEHA+ AGADA+AA Y+E+R+ ++PTGFG GIDAN+VTAS +A
Sbjct: 479 IDAFVNALDLPVRVMDYHEHAMSAGADARAACYVEVRVGDSPTGFGAGIDANLVTASLRA 538

Query: 542 VLSAVNRQIAISESANQAGSSQAKA 566
           V+S VNR +     A QA  S   A
Sbjct: 539 VISGVNRHLQAGFGAAQAPQSAEAA 563


>ref|YP_001796513.1| 2-isopropylmalate synthase [Cupriavidus taiwanensis LMG 19424]
 sp|B2AHM5.1|LEU1_CUPTR RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM
           synthase; AltName: Full=Alpha-isopropylmalate synthase
 emb|CAP63274.1| 2-isopropylmalate synthase 2 (Alpha-isopropylmalate synthase 2)
           (Alpha-IPM synthetase 2) [Cupriavidus taiwanensis LMG
           19424]
          Length = 569

 Score =  844 bits (2181), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 394/549 (71%), Positives = 463/549 (84%), Gaps = 2/549 (0%)

Query: 2   MLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFEL 61
           ML NPA KYRP   +D+PDRTWP + I   P WMSTDLRDGNQALIEPMN  RKLR FE 
Sbjct: 1   MLVNPATKYRPAATVDIPDRTWPGRTITRAPRWMSTDLRDGNQALIEPMNPARKLRLFEQ 60

Query: 62  LLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESLEGA 121
           L+K GLKEIEV FP+ASQTDFDFVR LI E RIPDDVTI+VLTQSR++LIRRT+ES+ GA
Sbjct: 61  LVKIGLKEIEVAFPAASQTDFDFVRMLIEERRIPDDVTIVVLTQSREDLIRRTVESVRGA 120

Query: 122 KKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESFS 181
            +A VHLYN +APA+R+IVFN SR+EIK +AV+GTRL+K LTDA P T W +EYSPE+FS
Sbjct: 121 ARATVHLYNPIAPAWRRIVFNASRDEIKAVAVSGTRLIKALTDAMPETAWTYEYSPETFS 180

Query: 182 TTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRASTI 241
             ELDFS E+ DAV   W A P R +ILNLP+TVEC+TPNV+ADQIEWM R L  RA  +
Sbjct: 181 LAELDFSLEVSDAVSAAWQAGPGRPMILNLPTTVECSTPNVFADQIEWMHRRLARRAHIV 240

Query: 242 ISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGLD 301
           +SVHPHNDRGTAVA+AELA+MAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGV P LD
Sbjct: 241 LSVHPHNDRGTAVAAAELALMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVAPELD 300

Query: 302 FSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPYL 361
           FSDID VRQ VE CNQ+PVHPRHPYVGDLVFTAFSGSHQDAI+KGFA+QQPDAIWEVPYL
Sbjct: 301 FSDIDAVRQCVEHCNQLPVHPRHPYVGDLVFTAFSGSHQDAIRKGFAQQQPDAIWEVPYL 360

Query: 362 PIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGKE 421
           PIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQ +GL LPRRLQIEFSRA+Q   D TG E
Sbjct: 361 PIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQVHGLYLPRRLQIEFSRAVQAMTDDTGLE 420

Query: 422 IAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNGP 481
            +A D++ +F+REYL R  P  Y +H+++ D++ A +I ++++  R+GQP TVRG+GNGP
Sbjct: 421 ASADDLYGLFRREYLARETPLRYVSHQLASDATGATAITVQME--RDGQPCTVRGTGNGP 478

Query: 482 IDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFKA 541
           IDAF+ AL L +++MD+HEHA+ AGADA+AA Y+E+R+ ++PTGFG GIDA++VTAS +A
Sbjct: 479 IDAFIDALDLPVRVMDYHEHAMTAGADARAACYVEVRVGDSPTGFGAGIDASLVTASLRA 538

Query: 542 VLSAVNRQI 550
           V+S VNR +
Sbjct: 539 VVSGVNRHL 547


>ref|YP_004680290.1| 2-isopropylmalate synthase LeuA [Cupriavidus necator N-1]
 gb|AEI79058.1| 2-isopropylmalate synthase LeuA [Cupriavidus necator N-1]
          Length = 565

 Score =  844 bits (2180), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 395/549 (71%), Positives = 461/549 (83%), Gaps = 2/549 (0%)

Query: 2   MLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFEL 61
           MLSNPA KY+P   +D+PDRTWP + I   P WMSTDLRDGNQALIEPMN  RKLRFFE 
Sbjct: 1   MLSNPATKYQPAATVDIPDRTWPGRTITRAPRWMSTDLRDGNQALIEPMNPARKLRFFEQ 60

Query: 62  LLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESLEGA 121
           L+K GLKEIEV FP+ASQTDFDFVR LI E RIPDDV I+VLTQSR++LIRRT++S+ GA
Sbjct: 61  LVKIGLKEIEVAFPAASQTDFDFVRMLIEEQRIPDDVNIVVLTQSREDLIRRTVQSVRGA 120

Query: 122 KKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESFS 181
            +A VHLYN +APA+R+IVFN SREEIK +AV+GTRL+K LTDA PGT W +EYSPE+FS
Sbjct: 121 ARATVHLYNPIAPAWRRIVFNASREEIKEVAVSGTRLIKALTDAMPGTAWTYEYSPETFS 180

Query: 182 TTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRASTI 241
             ELDFS E+ DAV   W A P R +ILNLP+TVEC+TPNV+ADQIEWM R L  R    
Sbjct: 181 LAELDFSLEVSDAVSAAWQAGPGRPMILNLPTTVECSTPNVFADQIEWMHRRLARREHIA 240

Query: 242 ISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGLD 301
           +SVHPHNDRGTAVA+AELA+MAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGV PGLD
Sbjct: 241 LSVHPHNDRGTAVAAAELALMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVAPGLD 300

Query: 302 FSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPYL 361
           FSDID VRQ VE CNQ+PVHPRHPYVGDLVFTAFSGSHQDAI+KGFA+QQPD+IWEVPYL
Sbjct: 301 FSDIDAVRQCVEHCNQLPVHPRHPYVGDLVFTAFSGSHQDAIRKGFAQQQPDSIWEVPYL 360

Query: 362 PIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGKE 421
           PIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQ +G+ +PRRLQIEFSRA+Q   D TG E
Sbjct: 361 PIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQVHGIYMPRRLQIEFSRAVQAMTDDTGLE 420

Query: 422 IAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNGP 481
            +A D++ +FQREYL +  P  Y +H++  DS  A    IEV +VR+G+  +VRG+GNGP
Sbjct: 421 ASADDLYGLFQREYLAQQTPLRYVSHQLVSDSGGA--TEIEVQMVRDGKQRSVRGTGNGP 478

Query: 482 IDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFKA 541
           IDAFV+AL L +++MD+HEHA+ AGADA+AA Y+E+R+ ++PTGFG GIDAN+VTAS +A
Sbjct: 479 IDAFVNALDLPVRVMDYHEHAMTAGADARAACYVEVRVGDSPTGFGAGIDANLVTASLRA 538

Query: 542 VLSAVNRQI 550
           V+S VNR +
Sbjct: 539 VISGVNRHL 547


>ref|YP_004418226.1| 2-isopropylmalate synthase [Pusillimonas sp. T7-7]
 gb|AEC21602.1| 2-isopropylmalate synthase [Pusillimonas sp. T7-7]
          Length = 567

 Score =  829 bits (2142), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 390/554 (70%), Positives = 460/554 (83%), Gaps = 4/554 (0%)

Query: 2   MLSNPAAKYRPFPAI--DLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFF 59
           M+SNP+ KYRPF A   D  +RTWPSK I  PPIWMSTDLRDGNQ+LIEPM+ ERKLRFF
Sbjct: 1   MISNPSDKYRPFVAFNRDFSERTWPSKRITHPPIWMSTDLRDGNQSLIEPMSVERKLRFF 60

Query: 60  ELLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESLE 119
           E L+K G KEIEVGFPSASQTDFDFVRKL+ ENRIPDDVTII LTQSR++LI+RT+ES  
Sbjct: 61  EQLIKIGFKEIEVGFPSASQTDFDFVRKLVDENRIPDDVTIIALTQSREDLIQRTVESAA 120

Query: 120 GAKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPES 179
           GAK+AI+HLYN+ APAFRKIVFNMS++E++ IA+TGTRLVKE T   P T WR+EYSPE 
Sbjct: 121 GAKQAIIHLYNACAPAFRKIVFNMSKDEVREIALTGTRLVKEYTSRHPETSWRYEYSPEV 180

Query: 180 FSTTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRAS 239
           FSTTE +F+ E+C+AV E W  +PE K+I NLP+T+E  TPN+YADQIEWM  NLK R  
Sbjct: 181 FSTTEPEFALEVCNAVTEVWQPTPESKIIYNLPATIEATTPNMYADQIEWMHNNLKQRDC 240

Query: 240 TIISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPG 299
            ++SVHPHNDRGTAVA+AELAVMAGADR+EGCLFGNGERTGNVDLVTLALNLYTQG++PG
Sbjct: 241 IVLSVHPHNDRGTAVAAAELAVMAGADRIEGCLFGNGERTGNVDLVTLALNLYTQGIHPG 300

Query: 300 LDFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVP 359
           LDFSDID VR+ VE CNQ+PVHPRHPY GDLVFTAFSGSHQDAIKKG A+QQ DA+WEVP
Sbjct: 301 LDFSDIDEVRRCVEYCNQLPVHPRHPYAGDLVFTAFSGSHQDAIKKGLARQQADALWEVP 360

Query: 360 YLPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATG 419
           YLPIDPADLGRSYDAVIRVNSQSGKGG++YLLE E+GL LPRRLQIEFSRAIQR  D TG
Sbjct: 361 YLPIDPADLGRSYDAVIRVNSQSGKGGVSYLLESEHGLVLPRRLQIEFSRAIQRVTDETG 420

Query: 420 KEIAASDIHAIFQREYLERVEPYVYRAHRMSED--SSKAESINIEVDIVRNGQPVTVRGS 477
            E+  S ++ +F  EYL++ +P+    HR++ D  ++  E   IEV++  NG    + G 
Sbjct: 421 AEVTTSQVYELFSTEYLQQEQPWKLVRHRITGDPKAANGEQFMIEVELEENGVVRNLVGR 480

Query: 478 GNGPIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTA 537
           G+G I AFV+AL ++I++MD+HEHAIG G D +AASY+ELR+ E+PTGFGVGI  +IVTA
Sbjct: 481 GDGAISAFVNALDMNIRVMDYHEHAIGTGTDTRAASYVELRVGESPTGFGVGIHGDIVTA 540

Query: 538 SFKAVLSAVNRQIA 551
           SF A+LSAVNR  A
Sbjct: 541 SFLAILSAVNRNAA 554


>ref|YP_001628685.1| 2-isopropylmalate synthase [Bordetella petrii DSM 12804]
 sp|A9HW07.1|LEU1_BORPD RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM
           synthase; AltName: Full=Alpha-isopropylmalate synthase
 emb|CAP40414.1| 2-isopropylmalate synthase [Bordetella petrii]
          Length = 568

 Score =  829 bits (2142), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 390/567 (68%), Positives = 471/567 (83%), Gaps = 4/567 (0%)

Query: 2   MLSNPAAKYRPFP--AIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFF 59
           ML+NPA KY PF   A D  +RTWPS+ I  PPIWMSTDLRDGNQ+LIEPM+ ERKLRFF
Sbjct: 1   MLANPATKYVPFAPFARDFSERTWPSRRITQPPIWMSTDLRDGNQSLIEPMSVERKLRFF 60

Query: 60  ELLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESLE 119
           E L+K G KEIEVGFPSASQTDFDFVRKL+ E RIPDDVTIIVLTQSR++LI RT+E+  
Sbjct: 61  EQLVKIGFKEIEVGFPSASQTDFDFVRKLVDEKRIPDDVTIIVLTQSREDLISRTVEAAA 120

Query: 120 GAKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPES 179
           GAK+AIVHLYN+ APAFRK+VFNMS++EIK IA++GT+ VK+     P T+WR+EYSPE 
Sbjct: 121 GAKQAIVHLYNACAPAFRKVVFNMSKDEIKQIAISGTQWVKQYMAQHPETQWRYEYSPEV 180

Query: 180 FSTTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRAS 239
           FSTTE +F+ E+ +AV + W  +PE K++LNLP+T+E  TPN+YADQIEWM +NL  R S
Sbjct: 181 FSTTEPEFALEVSNAVADVWQPTPECKMVLNLPATIEATTPNLYADQIEWMHKNLARRDS 240

Query: 240 TIISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPG 299
            ++SVHPHNDRGTAVA+AE AVMAGADR+EGCLFG+GERTGNVDLVTLALNLYTQGV+PG
Sbjct: 241 IVLSVHPHNDRGTAVAAAEFAVMAGADRIEGCLFGSGERTGNVDLVTLALNLYTQGVHPG 300

Query: 300 LDFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVP 359
           LDFSDID VR+  E CNQ+PVHPRHPY GDLVFTAFSGSHQDAIKKGFA+Q+PDA+WEVP
Sbjct: 301 LDFSDIDEVRRCAEYCNQLPVHPRHPYAGDLVFTAFSGSHQDAIKKGFAQQKPDAVWEVP 360

Query: 360 YLPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATG 419
           YLPIDPADLGRSYDAVIRVNSQSGKGG++YLLEQE+GL LPRRLQIEFSRAIQR  D TG
Sbjct: 361 YLPIDPADLGRSYDAVIRVNSQSGKGGVSYLLEQEHGLVLPRRLQIEFSRAIQRVTDETG 420

Query: 420 KEIAASDIHAIFQREYLERVEPYVYRAHRMSEDSS--KAESINIEVDIVRNGQPVTVRGS 477
           +E+ A D+H IF REYLE+  P+    HR+  D +  + +  +I+V++  NG+   V GS
Sbjct: 421 REVTADDVHTIFNREYLEQHSPWKLVRHRIDGDPAGGQGKQFSIQVELDYNGERRVVTGS 480

Query: 478 GNGPIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTA 537
           G+G I AFV ALG+ +++MD+HEHAIG G D +AASY+ELR+ ++ TGFGVGID +IVTA
Sbjct: 481 GDGAISAFVAALGIPVRIMDYHEHAIGTGTDTRAASYVELRVGDSATGFGVGIDRDIVTA 540

Query: 538 SFKAVLSAVNRQIAISESANQAGSSQA 564
           SF+AVLSAVNR +A   +  ++ ++QA
Sbjct: 541 SFQAVLSAVNRHLANGVTVTESETAQA 567


>gb|EFV84760.1| 2-isopropylmalate synthase [Achromobacter xylosoxidans C54]
          Length = 569

 Score =  829 bits (2141), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 394/568 (69%), Positives = 466/568 (82%), Gaps = 4/568 (0%)

Query: 1   MMLSNPAAKYRPFP--AIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRF 58
           MML+NPA KY PF   A D  +RTWPS+ I  PPIWMSTDLRDGNQALIEPM+ ERKLRF
Sbjct: 1   MMLANPATKYVPFTPFARDFSERTWPSRRITQPPIWMSTDLRDGNQALIEPMSVERKLRF 60

Query: 59  FELLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESL 118
           FE L+K G KEIEVGFPSASQTDFDFVRKLI E RIPDDVTIIVLTQSR++LI RT+ES 
Sbjct: 61  FEQLVKIGFKEIEVGFPSASQTDFDFVRKLIDEKRIPDDVTIIVLTQSREDLISRTVESA 120

Query: 119 EGAKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPE 178
            GAK+AIVHLYN+ APAFRK+VFNM+++EIKNIA TGTRLVK+     P T+WR++YSPE
Sbjct: 121 AGAKQAIVHLYNACAPAFRKVVFNMTKDEIKNIATTGTRLVKQYMARHPETKWRYQYSPE 180

Query: 179 SFSTTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRA 238
            FSTTE +F+ E+ +AV + W  +P+ K++LNLP+T+E  TPN+YADQIEWM +NL  R 
Sbjct: 181 VFSTTEPEFALEVSNAVADVWEPTPDCKMVLNLPATIEATTPNMYADQIEWMHKNLARRD 240

Query: 239 STIISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNP 298
           S ++SVHPHNDRGTAVA+AE AVMAGADR+EGCLFG+GERTGNVDLVTLALNLYTQGV+P
Sbjct: 241 SIVLSVHPHNDRGTAVAAAEFAVMAGADRIEGCLFGSGERTGNVDLVTLALNLYTQGVHP 300

Query: 299 GLDFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEV 358
           GLDFSDID VR+  E CNQ+PVHPRHPY GDLVFTAFSGSHQDAIKKGFA+QQPDA+WEV
Sbjct: 301 GLDFSDIDEVRRCAEYCNQLPVHPRHPYAGDLVFTAFSGSHQDAIKKGFAQQQPDAVWEV 360

Query: 359 PYLPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADAT 418
           PYLPIDPADLGRSYDAVIRVNSQSGKGG++YLLEQE+GL LPRRLQIEFSRAIQR  D T
Sbjct: 361 PYLPIDPADLGRSYDAVIRVNSQSGKGGVSYLLEQEHGLVLPRRLQIEFSRAIQRVTDET 420

Query: 419 GKEIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAES--INIEVDIVRNGQPVTVRG 476
           G+E+ A D+H IF REYLE+  P+    HR+  + +  E    +IE ++  NG+   V G
Sbjct: 421 GREVTADDVHTIFNREYLEQKAPWKLVRHRIDGNPAAGEGQHFSIEAELEYNGERRIVTG 480

Query: 477 SGNGPIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVT 536
            G+G I AFV AL + +++MD+HEHAIG G D +AASY+ELR+ ++ TGFGVGID +IVT
Sbjct: 481 KGDGAISAFVAALDVPVRIMDYHEHAIGTGTDTRAASYVELRVGDSSTGFGVGIDRDIVT 540

Query: 537 ASFKAVLSAVNRQIAISESANQAGSSQA 564
           ASF+AVLSAVNR I       +  ++QA
Sbjct: 541 ASFQAVLSAVNRHINAGAVITEQEAAQA 568