BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0049.p (230 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003776496.1| uroporphyrinogen-III C-methyltransferase [He... 462 e-128 ref|ZP_08273619.1| Uroporphyrinogen-III methyltransferase [Oxalo... 321 7e-86 ref|YP_004754159.1| uroporphyrinogen-III methyltransferase [Coll... 307 7e-82 ref|YP_001354147.1| uroporphyrin-III C-methyltransferase [Janthi... 300 8e-80 ref|YP_001100649.1| uroporphyrin-III C-methyltransferase [Hermin... 298 3e-79 ref|YP_004686738.1| uroporphyrin-III C-methyltransferase CysG [C... 225 4e-57 ref|YP_584953.1| uroporphyrin-III C-methyltransferase [Cupriavid... 224 7e-57 ref|YP_001155127.1| uroporphyrin-III C-methyltransferase [Polynu... 224 7e-57 ref|YP_727438.1| uroporphyrin-III C-methyltransferase [Ralstonia... 224 1e-56 ref|YP_003751710.1| uroporphyrinogen-III C-methyltransferase [Ra... 223 2e-56 >ref|YP_003776496.1| uroporphyrinogen-III C-methyltransferase [Herbaspirillum seropedicae SmR1] gb|ADJ64588.1| uroporphyrinogen-III C-methyltransferase protein [Herbaspirillum seropedicae SmR1] Length = 253 Score = 462 bits (1188), Expect = e-128, Method: Compositional matrix adjust. Identities = 230/230 (100%), Positives = 230/230 (100%) Query: 1 MVWLVGSGPGAADLLTVRAARLLAQAEIVLHDALVTPDILALCPQAVLVSVGKRSGQRST 60 MVWLVGSGPGAADLLTVRAARLLAQAEIVLHDALVTPDILALCPQAVLVSVGKRSGQRST Sbjct: 24 MVWLVGSGPGAADLLTVRAARLLAQAEIVLHDALVTPDILALCPQAVLVSVGKRSGQRST 83 Query: 61 AQPVINQKLVEAAQQYRRVVRLKGGDPMLFGRADEEMRALEEHHIPYEIVPGITAALAAA 120 AQPVINQKLVEAAQQYRRVVRLKGGDPMLFGRADEEMRALEEHHIPYEIVPGITAALAAA Sbjct: 84 AQPVINQKLVEAAQQYRRVVRLKGGDPMLFGRADEEMRALEEHHIPYEIVPGITAALAAA 143 Query: 121 SAAKRPLTRRGIARSVSLFTSSTGVDEPDEVRMPNGDTLVQYMGGREATATAQRLLALGH 180 SAAKRPLTRRGIARSVSLFTSSTGVDEPDEVRMPNGDTLVQYMGGREATATAQRLLALGH Sbjct: 144 SAAKRPLTRRGIARSVSLFTSSTGVDEPDEVRMPNGDTLVQYMGGREATATAQRLLALGH 203 Query: 181 APDTPVVVVENCSRPDQHIYHLQLAGLEAGLQACSGPVLVMIGPALADRH 230 APDTPVVVVENCSRPDQHIYHLQLAGLEAGLQACSGPVLVMIGPALADRH Sbjct: 204 APDTPVVVVENCSRPDQHIYHLQLAGLEAGLQACSGPVLVMIGPALADRH 253 >ref|ZP_08273619.1| Uroporphyrinogen-III methyltransferase [Oxalobacteraceae bacterium IMCC9480] gb|EGF32910.1| Uroporphyrinogen-III methyltransferase [Oxalobacteraceae bacterium IMCC9480] Length = 243 Score = 321 bits (822), Expect = 7e-86, Method: Compositional matrix adjust. Identities = 163/228 (71%), Positives = 193/228 (84%) Query: 2 VWLVGSGPGAADLLTVRAARLLAQAEIVLHDALVTPDILALCPQAVLVSVGKRSGQRSTA 61 VWLVG+GPGAADL+TVR ARLLA+AE+VL+DALVT D+LALCPQAVL++VGKR G RS A Sbjct: 7 VWLVGAGPGAADLITVRGARLLAEAEVVLYDALVTDDMLALCPQAVLIAVGKRCGLRSMA 66 Query: 62 QPVINQKLVEAAQQYRRVVRLKGGDPMLFGRADEEMRALEEHHIPYEIVPGITAALAAAS 121 Q INQ++++AA +Y RVVRLKGGDPMLFGRADEE+RA+E H I +VPGITAALAAA+ Sbjct: 67 QLAINQQIIDAAAKYSRVVRLKGGDPMLFGRADEELRAIESHGIECAVVPGITAALAAAA 126 Query: 122 AAKRPLTRRGIARSVSLFTSSTGVDEPDEVRMPNGDTLVQYMGGREATATAQRLLALGHA 181 ++K+PLTRRGIARSV+ FTSST D P++ +P DTLVQYMGGREA TA+ LLALGH Sbjct: 127 SSKQPLTRRGIARSVAFFTSSTAPDMPEQSTLPACDTLVQYMGGREAVKTARNLLALGHP 186 Query: 182 PDTPVVVVENCSRPDQHIYHLQLAGLEAGLQACSGPVLVMIGPALADR 229 PDTPV+VVENCSR D+HIY L L+ LE GL CSGPVL+MIG A+A R Sbjct: 187 PDTPVIVVENCSRADEHIYRLPLSQLEDGLPNCSGPVLMMIGAAMAAR 234 >ref|YP_004754159.1| uroporphyrinogen-III methyltransferase [Collimonas fungivorans Ter331] gb|AEK63336.1| Uroporphyrinogen-III methyltransferase [Collimonas fungivorans Ter331] Length = 264 Score = 307 bits (787), Expect = 7e-82, Method: Compositional matrix adjust. Identities = 157/228 (68%), Positives = 191/228 (83%) Query: 2 VWLVGSGPGAADLLTVRAARLLAQAEIVLHDALVTPDILALCPQAVLVSVGKRSGQRSTA 61 V+L+G+GPGAADL+TVR ARLLAQA++VLHDALVT ++LALCPQAV + VGKR G+ STA Sbjct: 20 VYLIGAGPGAADLITVRGARLLAQADVVLHDALVTEEMLALCPQAVKIPVGKRCGKLSTA 79 Query: 62 QPVINQKLVEAAQQYRRVVRLKGGDPMLFGRADEEMRALEEHHIPYEIVPGITAALAAAS 121 Q IN++++++A++Y VVRLKGGDPMLFGRADEE+RALE+H I E+VPGI+AALAAA+ Sbjct: 80 QQFINKQMIDSARKYALVVRLKGGDPMLFGRADEELRALEQHGIAAEVVPGISAALAAAA 139 Query: 122 AAKRPLTRRGIARSVSLFTSSTGVDEPDEVRMPNGDTLVQYMGGREATATAQRLLALGHA 181 ++PLT+RG+ARSV+ FTSST E D+V +P+ DTLVQYMGGREA ATAQRLLA G A Sbjct: 140 TTQQPLTKRGVARSVAFFTSSTAPGESDQVNIPSCDTLVQYMGGREAAATAQRLLAQGRA 199 Query: 182 PDTPVVVVENCSRPDQHIYHLQLAGLEAGLQACSGPVLVMIGPALADR 229 TPVVVVENCSR +Q I L+L LE+GLQ C GPVLVMIG ALA R Sbjct: 200 ASTPVVVVENCSRDNQRIQRLRLDRLESGLQLCEGPVLVMIGEALASR 247 >ref|YP_001354147.1| uroporphyrin-III C-methyltransferase [Janthinobacterium sp. Marseille] gb|ABR89207.1| uroporphyrin-III C-methyltransferase [Janthinobacterium sp. Marseille] Length = 239 Score = 300 bits (769), Expect = 8e-80, Method: Compositional matrix adjust. Identities = 152/229 (66%), Positives = 185/229 (80%) Query: 2 VWLVGSGPGAADLLTVRAARLLAQAEIVLHDALVTPDILALCPQAVLVSVGKRSGQRSTA 61 V+L+G+GPGA DL+TVR AR+LAQA++VLHDALVTP++L LCPQA +SVGKRSGQRSTA Sbjct: 11 VYLIGAGPGAVDLITVRGARILAQADVVLHDALVTPEMLELCPQAEKISVGKRSGQRSTA 70 Query: 62 QPVINQKLVEAAQQYRRVVRLKGGDPMLFGRADEEMRALEEHHIPYEIVPGITAALAAAS 121 Q INQ LV+ A +Y+ +VRLKGGDPMLFGRADEE+ ALE H I EIVPGIT A AAA+ Sbjct: 71 QLAINQLLVDCAAKYKLIVRLKGGDPMLFGRADEELHALEAHGIEIEIVPGITTAFAAAA 130 Query: 122 AAKRPLTRRGIARSVSLFTSSTGVDEPDEVRMPNGDTLVQYMGGREATATAQRLLALGHA 181 AA+ PLT+RGIARS++ FTS+T ++PD++ +P+ DTL+QYMGGREA TAQ+LL G + Sbjct: 131 AAQLPLTKRGIARSIAFFTSATAPNQPDQLTLPDCDTLIQYMGGREAMVTAQKLLEQGRS 190 Query: 182 PDTPVVVVENCSRPDQHIYHLQLAGLEAGLQACSGPVLVMIGPALADRH 230 PD PVV+VENCS P+Q I + L LE GLQ GPVLVMIG ALA R Sbjct: 191 PDLPVVIVENCSLPNQKIVRMNLRELERGLQDTQGPVLVMIGAALAARQ 239 >ref|YP_001100649.1| uroporphyrin-III C-methyltransferase [Herminiimonas arsenicoxydans] emb|CAL62528.1| Uroporphyrinogen-III C-methyltransferase [Herminiimonas arsenicoxydans] Length = 243 Score = 298 bits (764), Expect = 3e-79, Method: Compositional matrix adjust. Identities = 150/228 (65%), Positives = 185/228 (81%) Query: 2 VWLVGSGPGAADLLTVRAARLLAQAEIVLHDALVTPDILALCPQAVLVSVGKRSGQRSTA 61 V+L+G+GPGA DL+TVR AR+LAQA++VLHDALVTP++L LCPQA +SVGKRSGQRSTA Sbjct: 11 VYLIGAGPGAIDLITVRGARILAQADVVLHDALVTPEMLTLCPQAEKISVGKRSGQRSTA 70 Query: 62 QPVINQKLVEAAQQYRRVVRLKGGDPMLFGRADEEMRALEEHHIPYEIVPGITAALAAAS 121 Q INQ L+E A++Y+ +VRLKGGDPMLFGRADEE++ALE H I EIVPGIT A AAA+ Sbjct: 71 QIAINQLLIECAEKYQLIVRLKGGDPMLFGRADEELQALETHGIAVEIVPGITTAFAAAA 130 Query: 122 AAKRPLTRRGIARSVSLFTSSTGVDEPDEVRMPNGDTLVQYMGGREATATAQRLLALGHA 181 A ++PLT+RG+ARS++ FTSST ++PD++ +P+ DTL+QYMGGREA TAQ+LL G + Sbjct: 131 ATQQPLTKRGVARSIAFFTSSTAPNQPDQLTLPDCDTLIQYMGGREAIITAQKLLEQGRS 190 Query: 182 PDTPVVVVENCSRPDQHIYHLQLAGLEAGLQACSGPVLVMIGPALADR 229 P PVVVVENCS Q I + L LE GL C GPVLVMIG ALA+R Sbjct: 191 PRLPVVVVENCSLESQRIMRMTLHELEQGLGECQGPVLVMIGEALAER 238 >ref|YP_004686738.1| uroporphyrin-III C-methyltransferase CysG [Cupriavidus necator N-1] gb|AEI78257.1| uroporphyrin-III C-methyltransferase CysG [Cupriavidus necator N-1] Length = 266 Score = 225 bits (573), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 132/235 (56%), Positives = 162/235 (68%), Gaps = 7/235 (2%) Query: 2 VWLVGSGPGAADLLTVRAARLLAQAEIVLHDALVTPDILALCPQAVLVSVGKRSGQRSTA 61 V+L+G+GPGAADL+TVR ARLL +A++VLHDALV+P++LA CPQA LV VGKR GQRSTA Sbjct: 12 VFLIGAGPGAADLITVRGARLLGEAQVVLHDALVSPEMLAWCPQAELVEVGKRCGQRSTA 71 Query: 62 QPVINQKLVEAAQQYRRVVRLKGGDPMLFGRADEEMRALEEHHIPYEIVPGITAALAAAS 121 Q IN+++V+ A +Y RVVRLKGGDPMLFGRADEE++ALE I YE+VPGITAALAAAS Sbjct: 72 QLFINRQIVDLASKYERVVRLKGGDPMLFGRADEELQALEAAGIEYEVVPGITAALAAAS 131 Query: 122 AAKRPLTRRGIARSVSLFTSSTGVD---EPDEVRMPNGDTLVQYMGGREATATAQRLLAL 178 A +PLT+RG++RSV+ T + D D DTLV YMG +A + A +L+A Sbjct: 132 AIGKPLTKRGVSRSVAFATQAKAADGDGSADIEAAVKADTLVYYMGRDQAASIAAQLIAH 191 Query: 179 GHAPDTPVVVVENCSRPDQHIYHLQLAGLEAGLQACS----GPVLVMIGPALADR 229 G TP VVE S P Q L + AG A P L+MIG ALA R Sbjct: 192 GKPASTPAWVVEAASTPRQRSREFTLGRMAAGEAAAWIDPVQPSLLMIGAALAAR 246 >ref|YP_584953.1| uroporphyrin-III C-methyltransferase [Cupriavidus metallidurans CH34] gb|ABF09684.1| siroheme synthase (includes: uroporphyrin-III C-methyltransferase; precorrin-2 oxidase; ferrochelatase) [Cupriavidus metallidurans CH34] Length = 254 Score = 224 bits (571), Expect = 7e-57, Method: Compositional matrix adjust. Identities = 128/232 (55%), Positives = 161/232 (69%), Gaps = 4/232 (1%) Query: 2 VWLVGSGPGAADLLTVRAARLLAQAEIVLHDALVTPDILALCPQAVLVSVGKRSGQRSTA 61 V+L+G+GPGAADL+TVR ARLL +A++VLHDALV+P++LA CPQA LV VGKR GQRSTA Sbjct: 12 VYLIGAGPGAADLITVRGARLLGEAQVVLHDALVSPEMLAWCPQAELVEVGKRCGQRSTA 71 Query: 62 QPVINQKLVEAAQQYRRVVRLKGGDPMLFGRADEEMRALEEHHIPYEIVPGITAALAAAS 121 Q IN+++V+ A ++ RVVRLKGGDPMLFGRADEE++ALE I YE+VPGITAALAAAS Sbjct: 72 QLFINRQIVDLATKHERVVRLKGGDPMLFGRADEELQALEAAGIEYEVVPGITAALAAAS 131 Query: 122 AAKRPLTRRGIARSVSLFTSSTGVDEPDEVRMPNGDTLVQYMGGREATATAQRLLALGHA 181 A RPLT+RG++RSV+ T + D D DT++ YMG +A A +L+A G Sbjct: 132 AIGRPLTKRGVSRSVAFATQAKAADAVDVEADVKADTIIYYMGRDQAANIATQLIARGKP 191 Query: 182 PDTPVVVVENCSRPDQHIYHLQLAGLEAGLQACS----GPVLVMIGPALADR 229 TP VVE + P Q + L + AG A P L+MIG AL R Sbjct: 192 ASTPAWVVEAATTPRQRSHQFTLGQMAAGEAARWMDPVQPSLLMIGEALGSR 243 >ref|YP_001155127.1| uroporphyrin-III C-methyltransferase [Polynucleobacter necessarius subsp. asymbioticus QLW-P1DMWA-1] gb|ABP33563.1| uroporphyrinogen-III C-methyltransferase [Polynucleobacter necessarius subsp. asymbioticus QLW-P1DMWA-1] Length = 273 Score = 224 bits (571), Expect = 7e-57, Method: Compositional matrix adjust. Identities = 124/236 (52%), Positives = 165/236 (69%), Gaps = 13/236 (5%) Query: 2 VWLVGSGPGAADLLTVRAARLLAQAEIVLHDALVTPDILALCPQAVLVSVGKRSGQRSTA 61 V+LVG+GPGAADL+TVR A+LLAQA+IV HDALV P++LALCPQA+ ++VGKR G+ S+A Sbjct: 16 VYLVGAGPGAADLITVRGAKLLAQADIVFHDALVEPEMLALCPQAIQIAVGKRCGKLSSA 75 Query: 62 QPVINQKLVEAAQQYRRVVRLKGGDPMLFGRADEEMRALEEHHIPYEIVPGITAALAAAS 121 Q IN++LV+AAQ+Y+ VVRLKGGDPMLFGRADEE++AL I E+VPGITAALA A+ Sbjct: 76 QEFINKRLVDAAQKYQTVVRLKGGDPMLFGRADEEIQALNAAGIEMEVVPGITAALAGAA 135 Query: 122 AAKRPLTRRGIARSVSLFTSSTGV-----DEPDEVRMPNGDTLVQYMGGREATATAQRLL 176 + ++ LT RG++RSV+ T + G D+P + P DTLV YMG ++A AQ+L+ Sbjct: 136 SIQQSLTLRGVSRSVAFITLAQGAENLTSDQP--IANPTADTLVYYMGRKDAAKIAQQLI 193 Query: 177 AL-GH-APDTPVVVVENCSRPDQHIYHLQL----AGLEAGLQACSGPVLVMIGPAL 226 A H + TPV ++E S P + + L G G + P L+MIG AL Sbjct: 194 AQHSHMSQGTPVHILEAVSTPRERQWTSTLQELAEGKADGWFDSTSPALIMIGAAL 249 >ref|YP_727438.1| uroporphyrin-III C-methyltransferase [Ralstonia eutropha H16] emb|CAJ94070.1| Uroporphyrin-III C-methyltransferase [Ralstonia eutropha H16] Length = 266 Score = 224 bits (570), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 131/235 (55%), Positives = 161/235 (68%), Gaps = 7/235 (2%) Query: 2 VWLVGSGPGAADLLTVRAARLLAQAEIVLHDALVTPDILALCPQAVLVSVGKRSGQRSTA 61 V+L+G+GPGAADL+TVR ARLL +A++VLHDALV P++LA CPQA LV VGKR GQRSTA Sbjct: 12 VFLIGAGPGAADLITVRGARLLGEAQVVLHDALVAPEMLAWCPQAELVEVGKRCGQRSTA 71 Query: 62 QPVINQKLVEAAQQYRRVVRLKGGDPMLFGRADEEMRALEEHHIPYEIVPGITAALAAAS 121 Q IN+++V+ A +Y RVVRLKGGDPMLFGRADEE++ALE I YE+VPGITAALAAAS Sbjct: 72 QLFINRQIVDLAGKYERVVRLKGGDPMLFGRADEELQALEAAGIEYEVVPGITAALAAAS 131 Query: 122 AAKRPLTRRGIARSVSLFTSSTGVDEPDEVRMP---NGDTLVQYMGGREATATAQRLLAL 178 A +PLT+RG++RSV+ T + D + DTLV YMG +A + A +L+A Sbjct: 132 AIGKPLTKRGVSRSVAFATQAKAADGEGSADIEAAVKADTLVYYMGRDQAASIAAQLIAH 191 Query: 179 GHAPDTPVVVVENCSRPDQHIYHLQLAGLEAGLQACS----GPVLVMIGPALADR 229 G TP VVE S P Q L + AG A P L+MIG ALA R Sbjct: 192 GKPASTPAWVVEAASTPRQRSREFTLGRMAAGEAAAWIDPVQPSLLMIGAALAAR 246 >ref|YP_003751710.1| uroporphyrinogen-III C-methyltransferase [Ralstonia solanacearum PSI07] emb|CBJ50413.1| Uroporphyrinogen-III C-methyltransferase [Ralstonia solanacearum PSI07] emb|CCA82630.1| uroporphyrinogen-III C-methyltransferase [blood disease bacterium R229] Length = 269 Score = 223 bits (569), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 132/240 (55%), Positives = 165/240 (68%), Gaps = 13/240 (5%) Query: 2 VWLVGSGPGAADLLTVRAARLLAQAEIVLHDALVTPDILALCPQAVLVSVGKRSGQRSTA 61 V L+G+GPGAADL+TVR ARLL +AE+VLHDALV+P++ CPQAVL+ VGKR G+RSTA Sbjct: 13 VSLIGAGPGAADLITVRGARLLGEAEVVLHDALVSPEVFQYCPQAVLIPVGKRCGKRSTA 72 Query: 62 QPVINQKLVEAAQQYRRVVRLKGGDPMLFGRADEEMRALEEHHIPYEIVPGITAALAAAS 121 Q IN++LV+ A +Y+RVVRLKGGDPMLFGRADEE++ALE I YE+VPGITAALAAAS Sbjct: 73 QRFINRQLVDLATKYQRVVRLKGGDPMLFGRADEELQALEAAGIEYEVVPGITAALAAAS 132 Query: 122 AAKRPLTRRGIARSVSLFTSSTGVDEPD----EVRMP----NGDTLVQYMGGREATATAQ 173 A ++PLT+RG+ARSV+ T + D PD E +P D+L+ YMG +A + A Sbjct: 133 AIRQPLTKRGVARSVAFVTQAKAAD-PDTPAPEGAVPEPAVQADSLIYYMGRDQAASIAA 191 Query: 174 RLLALGHAPDTPVVVVENCSRPDQHIYHLQLAGLEAGLQAC----SGPVLVMIGPALADR 229 L+A G AP TP VVE + P Q L + G A P L+MIG A A R Sbjct: 192 DLIARGRAPSTPAWVVEAATTPQQRSACFTLQQMAEGAAAAWINPEHPSLLMIGEAFAMR 251