BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0037.0149.p (274 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8ISB9.1 D8ISB9_HERSS Cobalamin synthase EC=2.-.-.- 538 e-151 A4G3Q1.1 A4G3Q1_HERAR Cobalamin synthase EC=2.-.-.- 287 1e-75 A6SWY1.1 A6SWY1_JANMA Cobalamin synthase EC=2.-.-.- 265 5e-69 Q47JS3.1 Q47JS3_DECAR Cobalamin synthase EC=2.-.-.- 221 9e-56 C7RUT5.1 C7RUT5_ACCPU Cobalamin synthase EC=2.-.-.- 211 1e-52 Q143K2.1 Q143K2_BURXL Cobalamin synthase EC=2.-.-.- 199 5e-49 D5NPM9.1 D5NPM9_9BURK Cobalamin synthase EC=2.-.-.- 199 5e-49 B1Y854.1 COBS_LEPCP Cobalamin synthase EC=2.-.-.- 198 8e-49 B2T161.1 B2T161_BURPP Cobalamin synthase EC=2.-.-.- 197 9e-49 B5WTM0.1 B5WTM0_9BURK Cobalamin synthase EC=2.-.-.- 184 9e-45 >D8ISB9.1 D8ISB9_HERSS Cobalamin synthase EC=2.-.-.- Length = 274 Score = 538 bits (1387), Expect = e-151, Method: Compositional matrix adjust. Identities = 274/274 (100%), Positives = 274/274 (100%) Query: 1 MTEPTSSPSAPGRGLLYQLRLFFTALQFFTRLPIPRWVGFHPDWLAHSTRYFPLVGWIVA 60 MTEPTSSPSAPGRGLLYQLRLFFTALQFFTRLPIPRWVGFHPDWLAHSTRYFPLVGWIVA Sbjct: 1 MTEPTSSPSAPGRGLLYQLRLFFTALQFFTRLPIPRWVGFHPDWLAHSTRYFPLVGWIVA 60 Query: 61 WATALVYLLAVQFWPQPVAVLLGTAAGIWLTGAFHEDGFADLCDGLGGAVSRERALEIMR 120 WATALVYLLAVQFWPQPVAVLLGTAAGIWLTGAFHEDGFADLCDGLGGAVSRERALEIMR Sbjct: 61 WATALVYLLAVQFWPQPVAVLLGTAAGIWLTGAFHEDGFADLCDGLGGAVSRERALEIMR 120 Query: 121 DSRLGSYGVIGLVLLMLTRLAALAALQPWQILAALGIAHPLSRWLATCLIWRMDYVREEG 180 DSRLGSYGVIGLVLLMLTRLAALAALQPWQILAALGIAHPLSRWLATCLIWRMDYVREEG Sbjct: 121 DSRLGSYGVIGLVLLMLTRLAALAALQPWQILAALGIAHPLSRWLATCLIWRMDYVREEG 180 Query: 181 KSKLLAQRMSTGEFLVATVWVVVPVIGTVALGLMSWQHIAMGCGLAALAALWLAYRLQRR 240 KSKLLAQRMSTGEFLVATVWVVVPVIGTVALGLMSWQHIAMGCGLAALAALWLAYRLQRR Sbjct: 181 KSKLLAQRMSTGEFLVATVWVVVPVIGTVALGLMSWQHIAMGCGLAALAALWLAYRLQRR 240 Query: 241 LGGYTGDGLGAVQQLSETVFYLGVLASLPAFLSA 274 LGGYTGDGLGAVQQLSETVFYLGVLASLPAFLSA Sbjct: 241 LGGYTGDGLGAVQQLSETVFYLGVLASLPAFLSA 274 >A4G3Q1.1 A4G3Q1_HERAR Cobalamin synthase EC=2.-.-.- Length = 270 Score = 287 bits (734), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 142/253 (56%), Positives = 183/253 (72%) Query: 16 LYQLRLFFTALQFFTRLPIPRWVGFHPDWLAHSTRYFPLVGWIVAWATALVYLLAVQFWP 75 ++QLRLFF ALQFFTR+PIPRWVGF WL H++RYFP VG +VA ALVYLL FW Sbjct: 16 VHQLRLFFVALQFFTRIPIPRWVGFDERWLQHASRYFPAVGIVVALVCALVYLLGSLFWN 75 Query: 76 QPVAVLLGTAAGIWLTGAFHEDGFADLCDGLGGAVSRERALEIMRDSRLGSYGVIGLVLL 135 Q VAVLL +AGI+LTGAFHEDGFAD CDG GG ++ ER LEIM DSR+G+YG IG+ ++ Sbjct: 76 QSVAVLLSMSAGIYLTGAFHEDGFADTCDGFGGGMTEERVLEIMTDSRIGAYGAIGIGMM 135 Query: 136 MLTRLAALAALQPWQILAALGIAHPLSRWLATCLIWRMDYVREEGKSKLLAQRMSTGEFL 195 + + L+++ ++AAL I HP SR A L+WRM+YV+ GK+K + Q+MS GEF Sbjct: 136 LALKWVVLSSMPSPAVVAALLIVHPFSRLAAISLVWRMNYVKANGKAKPIGQQMSNGEFC 195 Query: 196 VATVWVVVPVIGTVALGLMSWQHIAMGCGLAALAALWLAYRLQRRLGGYTGDGLGAVQQL 255 +A+ ++P++ G M W+ IA G LAA+ +LWLA QRR+GGYTGD LGAVQQ Sbjct: 196 IASATALLPMVLFSLTGWMPWEAIAAGVLLAAIVSLWLARMFQRRIGGYTGDCLGAVQQA 255 Query: 256 SETVFYLGVLASL 268 +E YLG+LA+L Sbjct: 256 AEVACYLGILAAL 268 >A6SWY1.1 A6SWY1_JANMA Cobalamin synthase EC=2.-.-.- Length = 270 Score = 265 bits (677), Expect = 5e-69, Method: Compositional matrix adjust. Identities = 141/250 (56%), Positives = 180/250 (72%) Query: 16 LYQLRLFFTALQFFTRLPIPRWVGFHPDWLAHSTRYFPLVGWIVAWATALVYLLAVQFWP 75 L+QLRLFF ALQFFTR+P+PRWVGF WL H++RYFP VG +VA A+ +VY++A W Sbjct: 16 LHQLRLFFIALQFFTRIPVPRWVGFDVQWLQHASRYFPAVGIVVALASIVVYIIASLLWT 75 Query: 76 QPVAVLLGTAAGIWLTGAFHEDGFADLCDGLGGAVSRERALEIMRDSRLGSYGVIGLVLL 135 Q +AVLL T AGI+LTGAFHEDGFAD CDGLGG + ER LEIM+DSR+G+YG IG+ L+ Sbjct: 76 QSIAVLLSTIAGIYLTGAFHEDGFADTCDGLGGGGTPERVLEIMKDSRIGAYGAIGIGLM 135 Query: 136 MLTRLAALAALQPWQILAALGIAHPLSRWLATCLIWRMDYVREEGKSKLLAQRMSTGEFL 195 + + AL++L +++AL IAHPLSR A L+WRM+Y + GK+K +AQ+MS EF Sbjct: 136 LALKWMALSSLPSPAVVSALLIAHPLSRLAAISLVWRMEYAKANGKAKPIAQQMSNREFG 195 Query: 196 VATVWVVVPVIGTVALGLMSWQHIAMGCGLAALAALWLAYRLQRRLGGYTGDGLGAVQQL 255 +A +P+ GL+ +A G AALAA WLA QRR+ GYTGD LGAVQQ+ Sbjct: 196 IAAGTTFLPIALLCLTGLLPVSGVACGIFFAALAAFWLARLFQRRIAGYTGDTLGAVQQV 255 Query: 256 SETVFYLGVL 265 +E FYLGVL Sbjct: 256 AEVAFYLGVL 265 >Q47JS3.1 Q47JS3_DECAR Cobalamin synthase EC=2.-.-.- Length = 256 Score = 221 bits (563), Expect = 9e-56, Method: Compositional matrix adjust. Identities = 133/253 (52%), Positives = 169/253 (66%), Gaps = 8/253 (3%) Query: 18 QLRLFFTALQFFTRLPIPRWVGFHPDWLAHSTRYFPLVGWIVAWATALVYLLAVQFWPQP 77 +L FF A++FFTRLP+P WVG + L HS RYFP VG +V ALVY LA+ WPQP Sbjct: 5 ELEYFFGAIRFFTRLPVPGWVGHSAEALNHSARYFPAVGLLVGGIGALVYWLALYLWPQP 64 Query: 78 VAVLLGTAAGIWLTGAFHEDGFADLCDGLGGAVSRERALEIMRDSRLGSYGVIGLVLLML 137 VAVLL AA I+ TGAFHEDG +D DGLGG + R L+IM+DSR+GSYGV+ +VL +L Sbjct: 65 VAVLLSMAATIYATGAFHEDGLSDTVDGLGGGWEKARILDIMKDSRVGSYGVVAMVLALL 124 Query: 138 TRLAALAALQPWQILAALGIAHPLSRWLATCLIWRMDYVREE--GKSKLLAQRMSTGEFL 195 + L++L P + AL H +SR+ AT L+ MDYVR++ K+K LA RMS G + Sbjct: 125 GKFVLLSSLAPALVPFALLAGHAVSRFCATVLLATMDYVRDDQLSKAKPLANRMSAGAIV 184 Query: 196 VATVWVVVPVIGTVALGLMSWQHIAMGCGLAALAALWLAYRLQRRLGGYTGDGLGAVQQL 255 VA + V P++ + W A G LAALA LWLA + QR LGGYTGD LGA QQ Sbjct: 185 VALCFAVAPLLA------LPWFKAAAGLALAALATLWLARKFQRWLGGYTGDCLGATQQF 238 Query: 256 SETVFYLGVLASL 268 +E VFYLG++A+L Sbjct: 239 AEIVFYLGLMANL 251 >C7RUT5.1 C7RUT5_ACCPU Cobalamin synthase EC=2.-.-.- Length = 250 Score = 211 bits (536), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 121/249 (48%), Positives = 161/249 (64%), Gaps = 6/249 (2%) Query: 18 QLRLFFTALQFFTRLPIPRWVGFHPDWLAHSTRYFPLVGWIVAWATALVYLLAVQFWPQP 77 ++ FF A++FFTRLP+P WVG + L + RYFP VG +V ALV++L Q WP Sbjct: 5 EIEYFFGAIRFFTRLPVPAWVGHSSEALNRAARYFPAVGLLVGAIAALVFVLTAQVWPTT 64 Query: 78 VAVLLGTAAGIWLTGAFHEDGFADLCDGLGGAVSRERALEIMRDSRLGSYGVIGLVLLML 137 +AVL ++ +++TGAFHEDG++D+ DG GG + + L IM+DSR+GS+G I LV+L+L Sbjct: 65 LAVLASMSSALYVTGAFHEDGWSDMVDGFGGGWEKAQILAIMKDSRIGSFGAIALVILLL 124 Query: 138 TRLAALAALQPWQILAALGIAHPLSRWLATCLIWRMDYVREEGKSKLLAQRMSTGEFLVA 197 R AL L P + AAL H +SR+ AT L+ + YVR+EGKSK LA R+ GE L A Sbjct: 125 ARFCALIELDPAVVAAALLAGHTISRFAATTLLRGLAYVRDEGKSKPLATRIGWGELLFA 184 Query: 198 TVWVVVPVIGTVALGLMSWQHIAMGCGLAALAALWLAYRLQRRLGGYTGDGLGAVQQLSE 257 V V+P++ A + +GC AALA LWLA RR+GGYTGD LGA QQLSE Sbjct: 185 GVTAVLPLLLLPATEAL------LGCLFAALATLWLARLFGRRIGGYTGDCLGATQQLSE 238 Query: 258 TVFYLGVLA 266 FY G+L Sbjct: 239 VAFYCGLLC 247 >Q143K2.1 Q143K2_BURXL Cobalamin synthase EC=2.-.-.- Length = 258 Score = 199 bits (505), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 117/257 (45%), Positives = 153/257 (59%), Gaps = 20/257 (7%) Query: 16 LYQLRLFFTALQFFTRLPIPRWVGFHPDWLAHSTRYFPLVGWIVAWATALVYLLAVQFWP 75 L +LR FFTAL +FTR+P+PRWVG+ P +L + RYFPLVG ++ +ALVYL A+ +P Sbjct: 4 LTELRYFFTALGYFTRVPVPRWVGYEPHYLNAAARYFPLVGVLIGALSALVYLAALHVFP 63 Query: 76 QPVAVLLGTAAGIWLTGAFHEDGFADLCDGLGGAVSRERALEIMRDSRLGSYGVIGLVLL 135 VAVLL AA + +TGAFHEDG AD D GGA +RE L IM DSR+G++G I LV+ Sbjct: 64 AGVAVLLSMAASLLVTGAFHEDGLADCVDAFGGAYTREDVLRIMHDSRIGAFGAIALVMA 123 Query: 136 MLTRLAALAALQPWQILAALGIAHPLSRWLATCLIWRMDYVREEGKSKLLAQRMSTGEFL 195 + + ALAA+ P + + + AH SR A + +DYVR EGK+K +AQR+S G F+ Sbjct: 124 LALKWQALAAMPPLRAASLMIAAHAASRTCAISYLATLDYVRAEGKAKPVAQRLSGGAFI 183 Query: 196 VATV----WVVVPVIGTVALGLMSWQHIA----MGCGLAALAALWLAY--RLQRRLGGYT 245 A + W+ P W H G LA L L +A RR+GGYT Sbjct: 184 CAAICGLPWLFWP----------DWFHAPDWRFAGSALAGLVVLRVAMGRYFVRRIGGYT 233 Query: 246 GDGLGAVQQLSETVFYL 262 GD LG QQ+ E YL Sbjct: 234 GDCLGFAQQIFELSIYL 250 >D5NPM9.1 D5NPM9_9BURK Cobalamin synthase EC=2.-.-.- Length = 258 Score = 199 bits (505), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 117/257 (45%), Positives = 153/257 (59%), Gaps = 20/257 (7%) Query: 16 LYQLRLFFTALQFFTRLPIPRWVGFHPDWLAHSTRYFPLVGWIVAWATALVYLLAVQFWP 75 L +LR FFTAL +FTR+P+PRWVG+ P +L + RYFPLVG ++ +ALVYL A+ +P Sbjct: 4 LTELRYFFTALGYFTRVPVPRWVGYEPHYLNAAARYFPLVGVLIGALSALVYLAALHVFP 63 Query: 76 QPVAVLLGTAAGIWLTGAFHEDGFADLCDGLGGAVSRERALEIMRDSRLGSYGVIGLVLL 135 VAVLL AA + +TGAFHEDG AD D GGA +RE L IM DSR+G++G I LV+ Sbjct: 64 AGVAVLLSMAASLLVTGAFHEDGLADCVDAFGGAYTREDVLRIMHDSRIGAFGAIALVMA 123 Query: 136 MLTRLAALAALQPWQILAALGIAHPLSRWLATCLIWRMDYVREEGKSKLLAQRMSTGEFL 195 + + ALAA+ P + + + AH SR A + +DYVR EGK+K +AQR+S G F+ Sbjct: 124 LALKWQALAAMPPLRAASLMIAAHAASRTCAISYLATLDYVRAEGKAKPVAQRLSGGAFI 183 Query: 196 VATV----WVVVPVIGTVALGLMSWQHIA----MGCGLAALAALWLAY--RLQRRLGGYT 245 A + W+ P W H G LA L L +A RR+GGYT Sbjct: 184 CAAICGLPWLFWP----------DWFHAPDWRFAGSALAGLVVLRVAMGRYFVRRIGGYT 233 Query: 246 GDGLGAVQQLSETVFYL 262 GD LG QQ+ E YL Sbjct: 234 GDCLGFAQQIFELSIYL 250 >B1Y854.1 COBS_LEPCP Cobalamin synthase EC=2.-.-.- Length = 264 Score = 198 bits (503), Expect = 8e-49, Method: Compositional matrix adjust. Identities = 126/259 (48%), Positives = 159/259 (61%), Gaps = 6/259 (2%) Query: 15 LLYQLRLFFTALQFFTRLPIPRWVGFHPDWLAHSTRYFPLVGWIVAWATALVYLLAVQFW 74 L+++ RLFF ALQFFTR+P+P WVG+ P+W+ S R++PLVG V ALV LA Q W Sbjct: 4 LIHEARLFFIALQFFTRVPVPAWVGYTPEWMHASARHYPLVGAWVGGVAALVLWLAAQVW 63 Query: 75 PQPVAVLLGTAAGIWLTGAFHEDGFADLCDGLGGAVSRERALEIMRDSRLGSYGVIGLVL 134 P VAV L AA +WLTG FHEDG AD CDGLGG+VSRERAL IM+DSRLGSYG +GLV Sbjct: 64 PLSVAVGLSMAATVWLTGGFHEDGLADTCDGLGGSVSRERALTIMKDSRLGSYGALGLVG 123 Query: 135 LMLTRLAALAALQPW---QILAALGIAHPLSRWLATCLIWRMDYV--REEGKSKLLAQRM 189 ++ + AL L + Q L AL AH +SR + L+ + Y E K+K +AQ++ Sbjct: 124 VLGLKAVALYELTDFDGVQALIALVWAHAVSRAVPVALLRLLPYAGDAEHAKAKPMAQQV 183 Query: 190 STGEFLVATVWVVVPVIGTVALGLMSWQHIAMGCGLAALAALWLAYRLQRRLGGYTGDGL 249 S A W + LG ++ G+ ALAA + + Q RLGGYTGD L Sbjct: 184 SDAGLAAALGWAALACAAAWGLGASAFTLACAALGVIALAAFCVRWYRQ-RLGGYTGDTL 242 Query: 250 GAVQQLSETVFYLGVLASL 268 GA QQL E YLG LA + Sbjct: 243 GAAQQLCELAAYLGWLAGV 261 >B2T161.1 B2T161_BURPP Cobalamin synthase EC=2.-.-.- Length = 258 Score = 197 bits (502), Expect = 9e-49, Method: Compositional matrix adjust. Identities = 109/247 (44%), Positives = 151/247 (61%) Query: 16 LYQLRLFFTALQFFTRLPIPRWVGFHPDWLAHSTRYFPLVGWIVAWATALVYLLAVQFWP 75 L +LR FFTAL +FTR+P+PRWVG+ P +L + RYFPLVG ++ +ALVYL A++ +P Sbjct: 4 LAELRYFFTALGYFTRVPVPRWVGYEPHYLNAAARYFPLVGVLIGGLSALVYLAALRVFP 63 Query: 76 QPVAVLLGTAAGIWLTGAFHEDGFADLCDGLGGAVSRERALEIMRDSRLGSYGVIGLVLL 135 VAVLL AA + +TGAFHEDG AD D GGA +RE L IM DSR+G++G I LV+ Sbjct: 64 AGVAVLLSMAASLLVTGAFHEDGLADCVDAFGGAYTREDVLRIMHDSRIGAFGAIALVIA 123 Query: 136 MLTRLAALAALQPWQILAALGIAHPLSRWLATCLIWRMDYVREEGKSKLLAQRMSTGEFL 195 + + LAAL P + + + AH SR A + +DYVR EGK+K +AQR+S G F+ Sbjct: 124 LALKWQTLAALPPMRAASLMIAAHAASRTCAISYLATLDYVRAEGKAKPVAQRLSVGAFI 183 Query: 196 VATVWVVVPVIGTVALGLMSWQHIAMGCGLAALAALWLAYRLQRRLGGYTGDGLGAVQQL 255 A ++ + ++ L W+ + + + RR+GGYTGD LG QQ+ Sbjct: 184 CAAMFGLPWLLWPNGLAAPDWRFACSVVVVLVVLRAAMGRYFVRRIGGYTGDCLGFAQQV 243 Query: 256 SETVFYL 262 E YL Sbjct: 244 FELSIYL 250 >B5WTM0.1 B5WTM0_9BURK Cobalamin synthase EC=2.-.-.- Length = 258 Score = 184 bits (468), Expect = 9e-45, Method: Compositional matrix adjust. Identities = 111/247 (44%), Positives = 150/247 (60%) Query: 16 LYQLRLFFTALQFFTRLPIPRWVGFHPDWLAHSTRYFPLVGWIVAWATALVYLLAVQFWP 75 L +LR FFTAL +FTR+P+PRWVGF P +L + RYFPLVG +V ALVYL A++ +P Sbjct: 4 LAELRYFFTALGYFTRVPVPRWVGFEPHYLNAAARYFPLVGVLVGGLGALVYLAALRVFP 63 Query: 76 QPVAVLLGTAAGIWLTGAFHEDGFADLCDGLGGAVSRERALEIMRDSRLGSYGVIGLVLL 135 VAVLL +A + +TGAFHEDG AD D GGA SRE AL IM DSR+G++G I LV+ Sbjct: 64 PGVAVLLSMSASLIVTGAFHEDGLADCIDAFGGAYSREDALRIMHDSRIGAFGAIALVIA 123 Query: 136 MLTRLAALAALQPWQILAALGIAHPLSRWLATCLIWRMDYVREEGKSKLLAQRMSTGEFL 195 + + LAAL P + + + AH SR A + +DYVR GK+K +AQR+S L Sbjct: 124 LAIKWQTLAALPPLRAASLMIAAHGASRACAISYLATLDYVRAAGKAKPVAQRLSGPALL 183 Query: 196 VATVWVVVPVIGTVALGLMSWQHIAMGCGLAALAALWLAYRLQRRLGGYTGDGLGAVQQL 255 A ++ + ++ G W+ A+ C + + +R+GGYTGD LG QQ+ Sbjct: 184 CAALFGLPWLLWPNGPGAPDWRFAALTCAVLFALRFAMGRYFVKRIGGYTGDCLGFAQQI 243 Query: 256 SETVFYL 262 E YL Sbjct: 244 FELSIYL 250