BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0035.0123.p (1938 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IZT7.1 D8IZT7_HERSS Exported extracellular alpha-helical protein 3950 0.0 B3R7Q4.1 B3R7Q4_CUPTR Putative uncharacterized protein 1966 0.0 Q0K5I8.1 Q0K5I8_CUPNH Large extracellular alpha-helicalprotein 1962 0.0 C5CRS4.1 C5CRS4_VARPS Alpha-2-macroglobulin domain protein 1958 0.0 E6V2H6.1 E6V2H6_VARPD Alpha-2-macroglobulin domain protein 1956 0.0 C5T8V6.1 C5T8V6_ACIDE Alpha-2-macroglobulin domain protein 1948 0.0 Q1LHH3.1 Q1LHH3_RALME Large extracellular alpha-helicalprotein 1926 0.0 Q46VU1.1 Q46VU1_CUPPJ Alpha-2-macroglobulin, N-terminal 1926 0.0 A1TNJ9.1 A1TNJ9_ACIAC Alpha-2-macroglobulin domain protein 1925 0.0 F0Q8B4.1 F0Q8B4_ACIAP Alpha-2-macroglobulin domain protein 2 1920 0.0 >D8IZT7.1 D8IZT7_HERSS Exported extracellular alpha-helical protein Length = 1938 Score = 3950 bits (10245), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1928/1938 (99%), Positives = 1933/1938 (99%) Query: 1 MHAAALAFALGATMSLLPVKPAQAASATVQSFSPQGEVQRIRQVRARFSESMVKFGDPKA 60 MHAAALAFALGATMSLLPVKPAQAASATVQSFSPQGEVQRIRQVRARFSESMVKFGDPKA Sbjct: 1 MHAAALAFALGATMSLLPVKPAQAASATVQSFSPQGEVQRIRQVRARFSESMVKFGDPKA 60 Query: 61 ASPFDADCAVAGTARWADDKNWVYDFERDLPPGTRCSFTLRAEAKSVAGNSVGGKTRFQF 120 ASPFDADCAVAGTARWADD+NWVYDFERDLPPGTRCSFTLRAEAKSVAGNSVGGKTRFQF Sbjct: 61 ASPFDADCAVAGTARWADDRNWVYDFERDLPPGTRCSFTLRAEAKSVAGNSVGGKTRFQF 120 Query: 121 STGGPAVSRVQPYSGAQIAEDQAFILFQNGPATEPSVRQHLYCEAEGINERIPAKAVGEA 180 STGGPAVSRVQPYSGAQIAEDQAFILFQNGPATEPSVRQHLYCEAEGINERIPAKAVGEA Sbjct: 121 STGGPAVSRVQPYSGAQIAEDQAFILFQNGPATEPSVRQHLYCEAEGINERIPAKAVGEA 180 Query: 181 DRKALLQQFAKGVDPASVTIVQCQQRLPNEAHVKLVWDRGIAAANAPAVVTSQPQVFNFQ 240 DRKALLQQFAKGVDPASVTIVQCQQRLPNEAHVKLVWDRGIAAANAPAVVTSQPQVFNFQ Sbjct: 181 DRKALLQQFAKGVDPASVTIVQCQQRLPNEAHVKLVWDRGIAAANAPAVVTSQPQVFNFQ 240 Query: 241 VRSEFAASLSCQRENANAACSPILPVTLSFSAPVPRKLAEQVVMNATTGKIKPTLEGDKD 300 VRSEFAASLSCQRENANAACSPILPVTLSFSAPVPRKLAEQVVMNATTGKIKPTLEGDKD Sbjct: 241 VRSEFAASLSCQRENANAACSPILPVTLSFSAPVPRKLAEQVVMNATTGKIKPTLEGDKD 300 Query: 301 EAVRELRFKPPFPEKSDFTISLPSGFKDEDGRTLANAGAFPLKSALADFPPLAKFPAAPF 360 EAVRELRFKPPFPEKSDFTISLPSGFKDEDGRTLANAGAFPLKSALADFPPLAKFPAAPF Sbjct: 301 EAVRELRFKPPFPEKSDFTISLPSGFKDEDGRTLANAGAFPLKSALADFPPLAKFPAAPF 360 Query: 361 GIIELNADPTLPVTLRRVEAGLQVRGKDGRAMPGQVADLKVNGDKAVIAWLTRLNKYHEK 420 GIIELNADPTLPVTLRRVEAGLQVRGKDGRAMPGQVADLKVNGDKAVIAWLTRLNKYHEK Sbjct: 361 GIIELNADPTLPVTLRRVEAGLQVRGKDGRAMPGQVADLKVNGDKAVIAWLTRLNKYHEK 420 Query: 421 WGDPKKVDTRSVSLLAKESGAKKLDLPAQKDAKDGEWPFEVIGIPLKDPGFYVVELESQK 480 WGDPKKVDTRSVSLLAKE GAKKLDLPAQKDAK+GEWPFEVIGIPLKDPGFYVVELESQK Sbjct: 421 WGDPKKVDTRSVSLLAKEPGAKKLDLPAQKDAKEGEWPFEVIGIPLKDPGFYVVELESQK 480 Query: 481 LGASLLGKPQPMYVRTSALVTNLSVHVKLGRANGAVWVTRLDDAKPVADAEIRVSNCDGA 540 LGASLLGKPQPMYVRTSALVTNLSVHVKLGRANGAVWVTRLDDAKPVADAEIRVSNCDGA Sbjct: 481 LGASLLGKPQPMYVRTSALVTNLSVHVKLGRANGAVWVTRLDDAKPVADAEIRVSNCDGA 540 Query: 541 QIWQGKTNASGVAMMPALEDACANRGYSPDNADKINGLFVSARKTDEKGRQDMAFALTSW 600 QIWQGKTNASGVAMMPALEDACANRGYSPDNADKINGLFVSARKTDEKGRQDMAFALTSW Sbjct: 541 QIWQGKTNASGVAMMPALEDACANRGYSPDNADKINGLFVSARKTDEKGRQDMAFALTSW 600 Query: 601 NEGIESWRFNLPTDMDKSATVRATTVFDRTLFRAGETVSMKHVIRTETLQGFGLMRKEDL 660 NEGIESWRFNLPTDMDKSATVRATTVFDRTLFRAGETVSMKHVIRTETLQGFGLMRKEDL Sbjct: 601 NEGIESWRFNLPTDMDKSATVRATTVFDRTLFRAGETVSMKHVIRTETLQGFGLMRKEDL 660 Query: 661 PTRVRISHLGSGQQYQFPLTWRGNKSAETTFVLPKQAKLGSYEVVLDQGKVDANASAEPP 720 PTRVRISHLGSGQQYQFPLTWRGNKSAETTFVLPKQAKLGSYEVVLDQGKVDANASAEP Sbjct: 661 PTRVRISHLGSGQQYQFPLTWRGNKSAETTFVLPKQAKLGSYEVVLDQGKVDANASAEPT 720 Query: 721 EQSDDGDYEGGYGRGTYVTGSFRVEEFRLPLMQGRITPPKGAQVAVKEMPLDLQLNYING 780 EQSDDGDYEGGYGRGTYVTGSFRVEEFRLPLMQGRITPPKGAQVAVKEMPLDLQLNYING Sbjct: 721 EQSDDGDYEGGYGRGTYVTGSFRVEEFRLPLMQGRITPPKGAQVAVKEMPLDLQLNYING 780 Query: 781 GAAANQAVQVSSLLRSRSLNIAGYDGFSFDAPRSDEDSNADDQKIVADKLAITLDKNGAG 840 GAAANQAVQVSSLLRSRSLNIAGYDGFSFDAPRSD+DSNADDQKIVADKLAITLDKNGAG Sbjct: 781 GAAANQAVQVSSLLRSRSLNIAGYDGFSFDAPRSDDDSNADDQKIVADKLAITLDKNGAG 840 Query: 841 RATISKLPALQRPQELLTEMTYSDPNGEVQTISNVTPLWPSAVVVGLRTGNWVSVKKKLT 900 RATISKLPALQRPQELLTEMTYSDPNGEVQTISNVTPLWPSAVVVGLRTGNWVSVKKKLT Sbjct: 841 RATISKLPALQRPQELLTEMTYSDPNGEVQTISNVTPLWPSAVVVGLRTGNWVSVKKKLT 900 Query: 901 LTAVTLNTAGQPQAGVPVEIRGTARKTNSHRKRMVGGFYAYENDETKQDLGKLCSGKSDQ 960 LTAVTLNTAGQPQAGVPVEIRG ARKTNSHRKRMVGGFYAYENDE+KQDLGKLCSGKSDQ Sbjct: 901 LTAVTLNTAGQPQAGVPVEIRGIARKTNSHRKRMVGGFYAYENDESKQDLGKLCSGKSDQ 960 Query: 961 HGMFTCDTELSEAGNVELIASAKDGNGNAAAARSSVWVTGRGEVWFDGENQDRIDILPEK 1020 HGMFTCDTELSEAGNVELIASAKDGNGNAAAARSSVWVTGRGEVWFDGENQDRIDILPEK Sbjct: 961 HGMFTCDTELSEAGNVELIASAKDGNGNAAAARSSVWVTGRGEVWFDGENQDRIDILPEK 1020 Query: 1021 KNYQPGETANFQVRMPFRSATALVAVEREGVIDTRVVQLSGQDPTISVPMKAEYGPNVYV 1080 KNYQPGETANFQVRMPFRSATALVAVEREGVIDTRVVQLSGQDPTISVPMKAEYGPNVYV Sbjct: 1021 KNYQPGETANFQVRMPFRSATALVAVEREGVIDTRVVQLSGQDPTISVPMKAEYGPNVYV 1080 Query: 1081 SVLAVRGRMREVPWYSFFIWGWKEPINWWHEFREYQGPGPIVDLSKPAWKFGIAEVNVGD 1140 SVLAVRGRMREVPWYSFFIWGWKEPINWWHEFREYQGPGPIVDLSKPAWKFGIAEVNVGD Sbjct: 1081 SVLAVRGRMREVPWYSFFIWGWKEPINWWHEFREYQGPGPIVDLSKPAWKFGIAEVNVGD 1140 Query: 1141 AGHRLQVAVSTDKPTYPIRAIAKVQVQVKLPNGKPAAGGEFALAAVDEALLELQPNGSWD 1200 AGHRLQVAVSTDKPTYPIRAIAKVQVQVKLPNGKPAAGGEFALAAVDEALLELQPNGSWD Sbjct: 1141 AGHRLQVAVSTDKPTYPIRAIAKVQVQVKLPNGKPAAGGEFALAAVDEALLELQPNGSWD 1200 Query: 1201 VLHAMLQRRSYGVETSTAQMQVVGKRHYGKKATPAGGGGGRAPTRELFDTLLVWKPNVTL 1260 VLHAMLQRRSYGVETSTAQMQVVGKRHYGKKATPAGGGGGRAPTRELFDTLLVWKPNVTL Sbjct: 1201 VLHAMLQRRSYGVETSTAQMQVVGKRHYGKKATPAGGGGGRAPTRELFDTLLVWKPNVTL 1260 Query: 1261 DAEGRAQLDVPLNDALTSFRIVAIAENGISDFGTGSISIRSTQDVQVISGLPPLVREGDS 1320 DAEGRAQLDVPLNDALTSFRIVAIAENGISDFGTGSISIRSTQDVQVISGLPPLVREGDS Sbjct: 1261 DAEGRAQLDVPLNDALTSFRIVAIAENGISDFGTGSISIRSTQDVQVISGLPPLVREGDS 1320 Query: 1321 FNGAVTVRNTTTHDMTIKVAARAQGGTATSTLTLPEREVKIAAGQSAEVMWPVQTPEGIN 1380 FNGAVTVRNTTTHDMTIKVAARAQGGTA STLTLPEREVKIAAGQSAEVMWPVQTPEGIN Sbjct: 1321 FNGAVTVRNTTTHDMTIKVAARAQGGTAASTLTLPEREVKIAAGQSAEVMWPVQTPEGIN 1380 Query: 1381 QLAWEISAQEQGGQKARDAMKFTQRVVPAVPVTVQQATLFQLDKNAALDVARPADSLPGR 1440 QLAWEISAQEQGGQKARDAMKFTQRVVPAVPVTVQQATLFQLDKNAALDVARPADSLPGR Sbjct: 1381 QLAWEISAQEQGGQKARDAMKFTQRVVPAVPVTVQQATLFQLDKNAALDVARPADSLPGR 1440 Query: 1441 GGLAISLKPSLAGGSDALTRYFVNYPFACLEQKTSKAIGLRDEAAWQKIVADLPTYLDGD 1500 GGLAISLKPSLAGGSDALTRYFVNYPFACLEQKTSKAIGLRDEAAWQKIVADLPTYLDGD Sbjct: 1441 GGLAISLKPSLAGGSDALTRYFVNYPFACLEQKTSKAIGLRDEAAWQKIVADLPTYLDGD 1500 Query: 1501 GLAYYFPPSDSGARRGSDTLTAYLLAATNEAGYAIPQASRDKMLDGLAAFVEGKVMRDFW 1560 GLAYYFPPSDSGARRGSDTLTAYLLAATNEAGYAIPQASRDKMLDGLAAFVEGKVMRDFW Sbjct: 1501 GLAYYFPPSDSGARRGSDTLTAYLLAATNEAGYAIPQASRDKMLDGLAAFVEGKVMRDFW 1560 Query: 1561 SPQKDLDVRKLAALEALSRYNRVQPAMLGSLQINPNVWPTSGLLDWIAILQRVPAIPDRQ 1620 SPQKDLDVRKLAALEALSRYNRVQPAMLGSLQINPNVWPTSGLLDWI ILQRVPAIPDRQ Sbjct: 1561 SPQKDLDVRKLAALEALSRYNRVQPAMLGSLQINPNVWPTSGLLDWIGILQRVPAIPDRQ 1620 Query: 1621 KKLDEADQILRARLNFQGTRMGFSNEEGDYWWWLMSSGDANANRLILLELNNPAWREDMP 1680 KKLDEADQILRARLNFQGTRMGFSNEEGDYWWWLMSSGDANANRLILLELNNPAWREDMP Sbjct: 1621 KKLDEADQILRARLNFQGTRMGFSNEEGDYWWWLMSSGDANANRLILLELNNPAWREDMP 1680 Query: 1681 RLIAGAIGRQQRGHWSTTTANVWGSLALEKFARKFESEPVTGATRATLEQNGASAATQSL 1740 RLIAGAIGRQQRGHWSTTTANVWGSLALEKFARKFESEPVTGATRATLEQNGASAATQSL Sbjct: 1681 RLIAGAIGRQQRGHWSTTTANVWGSLALEKFARKFESEPVTGATRATLEQNGASAATQSL 1740 Query: 1741 AWSGAPNGGKLQLPWPEGNAQGGSVRLAQEGNGKPWVTLQSLAAVPLKQPFAAGYRITRK 1800 AWSGAPNGGKLQLPWPEGNAQGGSVRLAQEGNGKPWVTLQSLAAVPLKQPFAAGYRITRK Sbjct: 1741 AWSGAPNGGKLQLPWPEGNAQGGSVRLAQEGNGKPWVTLQSLAAVPLKQPFAAGYRITRK 1800 Query: 1801 VEAIEQKQAGVYTRGDVLRVTLDIDAQAEMTWVVVSDPVPGGATLLGSGLGRDSAIAQGK 1860 VEAIEQKQAGVYTRGDVLRVTLDIDAQAEMTWVVVSDPVPGGATLLGSGLGRDSAIAQGK Sbjct: 1801 VEAIEQKQAGVYTRGDVLRVTLDIDAQAEMTWVVVSDPVPGGATLLGSGLGRDSAIAQGK 1860 Query: 1861 QDAPRERGMGWLAYEERSFEAYRAYYEAMPKGRTSISYTVRLNNAGEFNLPPTRVEAMYA 1920 QDAPRERGMGWLAYEERSFEAYRAYYEAMPKGRTSISYTVRLNNAGEFN+PPTRVEAMYA Sbjct: 1861 QDAPRERGMGWLAYEERSFEAYRAYYEAMPKGRTSISYTVRLNNAGEFNMPPTRVEAMYA 1920 Query: 1921 PEMFGEVPNGKLVVKAAQ 1938 PEMFGEVPNGKLVVKAAQ Sbjct: 1921 PEMFGEVPNGKLVVKAAQ 1938 >B3R7Q4.1 B3R7Q4_CUPTR Putative uncharacterized protein Length = 2023 Score = 1966 bits (5093), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1038/2023 (51%), Positives = 1343/2023 (66%), Gaps = 146/2023 (7%) Query: 21 PAQAASATVQSFSPQGEVQRIRQVRARFSESMVKFGDPKAASPFDADC---AVAGTARWA 77 P A +A V FSP+G V ++RQV RF E+MV GD +AA+P C + +G ARW Sbjct: 38 PGGALAAQVSRFSPEGTVGQVRQVAIRFDEAMVPMGDVQAAAPAAVSCTGASTSGQARWI 97 Query: 78 DDKNWVYDFERDLPPGTRCSFTLRAEAKSVAGNSVGGKTRFQFSTGGPAVSRVQPYSGAQ 137 D +NWVYDF DLPPG RC+ +RA +S AG + GK ++F TGGP V +P SG + Sbjct: 98 DARNWVYDFASDLPPGVRCTVRMRAGLRSEAGTAYAGKAEYRFETGGPTVVSSRP-SGGE 156 Query: 138 IAEDQAFILFQNGPATEPSVRQHLYCEAEGINERIPAKAVGEADRKALLQ-----QFAKG 192 I EDQ F L NG T SVR+H +C+A+G+ ERIP + + +R+A+L+ + AK Sbjct: 157 IEEDQVFALRFNGATTAASVREHAWCQAQGLGERIPVRLLAGKEREAVLEAIRWDRLAKP 216 Query: 193 VDPASVTIVQCQQRLPNEAHVKLVWDRGIAAANAPAVVTSQPQVFNFQVRSEFAASLSCQ 252 + P +V ++ CQQRLP A V+LV GIA + V T + + F++ VR F AS SC+ Sbjct: 217 M-PDAVHLLACQQRLPAAARVQLVLGAGIATPSG--VATREERRFDYTVREPFTASFSCE 273 Query: 253 RENANAACSPILPVTLSFSAPVPRKLAEQVVMNATTGKIKPTLEGD--KDEAVRELRFKP 310 RE+A + C+P+ P+T++FSAPVPRKLAE VV+ +G P + D D +V L F Sbjct: 274 REHAQSPCTPLRPMTVTFSAPVPRKLAESVVLKTPSGPRAPQFDPDLAPDASVSALTFAA 333 Query: 311 PFPEKSDFTISLPSGFKDEDGRTLANAGAFPLKSALADFPPLAKFPAAPFGIIELNAD-- 368 PF EK+ FTI +P +D+ GR LANA FPLK A A PPLAKF AAPFG++E + Sbjct: 334 PFAEKAQFTIEVPRKLQDDSGRPLANADLFPLKVATAAMPPLAKFAAAPFGVVERFGELP 393 Query: 369 ---------PTLPVTLRRVEAGLQVRGKDGRAMPGQVADLKVNGDKAVIAWLTRLNKYHE 419 P LPVTLR VEA L VRG RA G V L+V+ D AV+ WL + + HE Sbjct: 394 RGKSAQDYPPLLPVTLRNVEADLSVRGVQARA--GTVMKLRVDDDAAVMQWLGLVRRLHE 451 Query: 420 ------------------KWGDPKK---VDTRSVSLLAKESGAKKLDLPAQKDAKDGEWP 458 + +P+ ++TRSVSLL + G +KL +P K + D P Sbjct: 452 ASYTRGELDAVLAGRSPYRVSNPRNAVSIETRSVSLLERAPGVQKLAVP--KPSGDAPRP 509 Query: 459 FEVIGIPLKDPGFYVVELESQKLGASLLGKPQPMYVRTSALVTNLSVHVKLGRANG---- 514 FEV+GIPL +PGF+VVE+ S LG +LLGK PMYVRT+ALVTNL VH KLGR +G Sbjct: 510 FEVVGIPLPEPGFHVVEIASPMLGEALLGKRAPMYVRTAALVTNLGVHFKLGRGSGNEDD 569 Query: 515 -----AVWVTRLDDAKPVADAEIRVSNCDGAQIWQGKTNASGVA----MMPALEDACANR 565 WVT LDD KPV+DA + V +C G + +G+T+ASGVA + A E AC Sbjct: 570 GSRSGLAWVTALDDGKPVSDAAVAVRDCSGRLLGEGRTDASGVARFARLAAAPESACDQN 629 Query: 566 GYSPDNADKINGLFVSAR----KTDEKGRQDMAFALTSWNEGIESWRFNLPTDMDKSATV 621 G S G FVSAR +G+ DMAF ++ WN GIESWRFN+PTD + TV Sbjct: 630 GLS--------GYFVSARIAATHPQARGKADMAFVMSDWNRGIESWRFNVPTDTSATPTV 681 Query: 622 RATTVFDRTLFRAGETVSMKHVIRTETLQGFGLM-RKEDLPTRVRISHLGSGQQYQFPLT 680 RA T+FDRTL RAGETVSMKH+IR ET QGF L LPTRV I H GSGQ Y+ PL Sbjct: 682 RAHTIFDRTLLRAGETVSMKHLIRAETAQGFALPPASRPLPTRVTIRHEGSGQSYELPLQ 741 Query: 681 WR----GNKSAETTFVLPKQAKLGSYEVVLDQGKVDANASAEPPEQSDDGDYEGGYGRGT 736 WR G +SAE+TF +P A+LG Y V L+ K D D+G G + Sbjct: 742 WRQTATGGRSAESTFQVPAAARLGVYTVELETQKGDG--------AKDEG------GVRS 787 Query: 737 YVTGSFRVEEFRLPLMQG--RITPPKGAQVAVKEMPLDLQLNYINGGAAANQAVQVSSLL 794 Y +GSFRVE FRLP++ G ++ G VA E+P+ ++++Y++GG AA V+VS+LL Sbjct: 788 YTSGSFRVEAFRLPVLAGTLQVAGKAGPVVAPAELPVGVEIHYLSGGGAAGLPVRVSALL 847 Query: 795 RSRSLNIAGYDGFSFDAPRSDEDSNADD--------------QKIVADKLAITLDKNGAG 840 R + ++ GYDGFSF PR+ +S D+ QK+VADKL +TLDKNG G Sbjct: 848 RDKYVSFPGYDGFSFTPPRAQRESGGDEEMDEDQQGGASDDRQKLVADKLPLTLDKNGNG 907 Query: 841 RATISKLPALQRPQELLTEMTYSDPNGEVQTISNVTPLWPSAVVVGLRTGNWVSVKKKLT 900 T++KLP + P++L+ E ++DPNGE+QT+ P+WP+AVV G+RT +WVSVK+KL Sbjct: 908 SVTLTKLPKTEAPRDLVLEAGFADPNGEIQTLRQTVPVWPAAVVAGIRTDDWVSVKQKLA 967 Query: 901 LTAVTLNTAGQPQAGVPVEIRGTARKTNSHRKRMVGGFYAYENDETKQDLGKLCSGKSDQ 960 + V L+ G+P A PV+I AR T S RKR+VGGFY Y+N +DLG +C ++D Sbjct: 968 VQGVVLDVNGKPVADAPVKINARARITTSARKRVVGGFYRYDNRTETRDLGTVCETRTDA 1027 Query: 961 HGMFTCDTELSEAGNVELIASAKDGNGNAAAARSSVWVTGRGEVWFDGENQDRIDILPEK 1020 G CD L +AG +EL+A+A+D +G A A ++VWVT +GE+WF GEN DRID+LPEK Sbjct: 1028 QGRARCDVTLEQAGQIELVANARDKDGRTAQAATTVWVTRQGELWFGGENHDRIDLLPEK 1087 Query: 1021 KNYQPGETANFQVRMPFRSATALVAVEREGVIDTRVVQLSGQDPTISVPMKAEYGPNVYV 1080 K+Y PG+TA FQVRMPFR ATALVAVEREG+ T+VV+L G DPT+ V +K E+GPNVYV Sbjct: 1088 KSYAPGDTAVFQVRMPFRHATALVAVEREGIYQTQVVELHGSDPTVRVQVKPEWGPNVYV 1147 Query: 1081 SVLAVRGRMREVPWYSFFIWGWKEPINWWHEF----REYQGPGPIVDLSKPAWKFGIAEV 1136 SVLA+RGR+ EVPWYSFF WGW++P WW F REY P +VDLSKPA++ G+AE+ Sbjct: 1148 SVLALRGRLHEVPWYSFFTWGWRQPGEWWRAFRSEGREYAAPTALVDLSKPAFRLGLAEI 1207 Query: 1137 NVGDAGHRLQVAVSTDKPTYPIRAIAKVQVQVKLPNGKPAAGGEFALAAVDEALLELQPN 1196 VG+AGHRL VAV+ DK +YP+R A+V +QV+LP+GKPAA GE ALAAVD+ALLEL PN Sbjct: 1208 RVGNAGHRLDVAVTPDKASYPVRGKARVAIQVRLPDGKPAANGEVALAAVDQALLELMPN 1267 Query: 1197 GSWDVLHAMLQRRSYGVETSTAQMQVVGKRHYGKKATPAGGGGGRAPTRELFDTLLVWKP 1256 SWD+L AMLQRR YGVETSTAQM+++G+RHYG+KA PAGGGGG++PTRELFDTLL+W P Sbjct: 1268 TSWDLLDAMLQRRGYGVETSTAQMEIIGRRHYGRKAVPAGGGGGKSPTRELFDTLLLWNP 1327 Query: 1257 NVTLDAEGRAQLDVPLNDALTSFRIVAIAENGISDFGTGSISIRSTQDVQVISGLPPLVR 1316 V LDAEGRA ++VPLND+LTSFRIVA+A+ G+ FGTGS +I +TQD+QVISGLPPLVR Sbjct: 1328 RVQLDAEGRASVEVPLNDSLTSFRIVAVADQGLGRFGTGSATIAATQDLQVISGLPPLVR 1387 Query: 1317 EGDSFNGAVTVRNTTTHDMTIKVAARAQGGTATSTLTLPEREVKIAAGQSAEVMWPVQTP 1376 E D + T+RNTT MT++ +AR G + LP + V+I AG++ E+ W V P Sbjct: 1388 EDDRYRAMFTLRNTTRRAMTVQASAR--GTLLGNEAGLPAQTVQIPAGEAREIGWDVTAP 1445 Query: 1377 EGI-----NQLAWEISAQEQGGQKARDAMKFTQRVVPAVPVTVQQATLFQLDKNAALDVA 1431 + + WE+ A EQG A D +K +Q++VPA PVTVQQATL Q+ + ++ V Sbjct: 1446 ALLAYARTGTVMWEVQASEQGTGGAADRIKVSQQIVPAAPVTVQQATLAQVAPSLSIPVK 1505 Query: 1432 RPADSLPG-----RGGLAISLKPSLAGGSDALTRYFVNYPFACLEQKTSKAIGLRDEAAW 1486 P +L RGG+ ++ + SLAGG + +F NYPF CLEQ+ SKAIGL D AAW Sbjct: 1506 APPGALADPAGKVRGGVQVNFQSSLAGGMPGVREWFRNYPFTCLEQRASKAIGLNDGAAW 1565 Query: 1487 QKIVADLPTYLDGDGLAYYFPPSDSGARRGSDTLTAYLLAATNEAGYA-----IPQASRD 1541 + ++A LP+YLD +GLA YF P +S + GS+ LTAYLLA T+EA A IP A R Sbjct: 1566 EALMAQLPSYLDANGLASYF-PLNSDSDYGSEVLTAYLLAVTDEAARAGLALRIPDAQRA 1624 Query: 1542 KMLDGLAAFVEGKVMRDFWSP---QKDLDVRKLAALEALSRYNRVQPAMLGSLQINPNVW 1598 +M GL FVEG++ RD WSP + L+VRKL+ALEALSR Q MLGS+QI P W Sbjct: 1625 QMERGLTDFVEGRIRRDSWSPVAGTQYLEVRKLSALEALSRTGHAQARMLGSIQILPAQW 1684 Query: 1599 PTSGLLDWIAILQRVPAIPDRQKKLDEADQILRARLNFQGTRMGFSNEEGDYWWWLMSSG 1658 PTS LLDW +L R+ IP R+++L EA Q+LR+RL QGTR+ FS E D WWW+M+ G Sbjct: 1685 PTSALLDWALLLTRMQDIPQREQRLAEAQQLLRSRLTVQGTRLAFSTERNDNWWWMMAGG 1744 Query: 1659 DANANRLILLELNNPAWREDMPRLIAGAIGRQQRGHWSTTTANVWGSLALEKFARKFESE 1718 D NA RL+ L P W+ED P+L G +GRQ G W TTTAN WG LA+ +FA+ FE Sbjct: 1745 DVNAARLLALASELPGWKEDAPQLATGLLGRQVHGAWGTTTANAWGMLAVTRFAQAFEKT 1804 Query: 1719 PVTGATRATLEQNGASAATQSLAWSGAPNG-----GKLQLPWPEGNAQGGSVRLAQEGNG 1773 PV G TRA++ + A+ A +S W+ A G + LPWP G A+GG++++ Q G G Sbjct: 1805 PVAGTTRASI--SNAADAARSFDWARAQRSDGVAQGSVDLPWPAG-AEGGTLQVEQAGAG 1861 Query: 1774 KPWVTLQSLAAVPLKQPFAAGYRITRKVEAIEQKQAGVYTRGDVLRVTLDIDAQAEMTWV 1833 +PW T++++AAVP+ P AAGYRI R V EQ G ++RGDV RV L+IDAQA+MTWV Sbjct: 1862 QPWATVRAMAAVPVTAPLAAGYRIQRTVTPQEQAVPGKWSRGDVYRVKLEIDAQADMTWV 1921 Query: 1834 VVSDPVPGGATLLGSGLGRDSAIAQGKQDAPRERGMGWLAYEERSFEAYRAYYEAMPKGR 1893 VVSDPVP GAT+LGSGLGRDSAIA + R +G W AY ER+ +AYR Y+ +PKG+ Sbjct: 1922 VVSDPVPAGATILGSGLGRDSAIATRGE---RRQGAAWPAYVERTPQAYREYFGYLPKGK 1978 Query: 1894 TSISYTVRLNNAGEFNLPPTRVEAMYAPEMFGEVPNGKLVVKA 1936 S+ YTVRLNNAG+F LPPTRVEAMYAP++FG PN +L V A Sbjct: 1979 VSVEYTVRLNNAGDFALPPTRVEAMYAPDVFGVAPNARLAVGA 2021 >Q0K5I8.1 Q0K5I8_CUPNH Large extracellular alpha-helicalprotein Length = 2023 Score = 1962 bits (5084), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1050/2044 (51%), Positives = 1341/2044 (65%), Gaps = 149/2044 (7%) Query: 1 MHAAALAFALGATMSLLPVKPAQAASATVQSFSPQGEVQRIRQVRARFSESMVKFGDPKA 60 +HA AL AT+ +L A +A V FSP+G V ++RQV RF E+MV GD +A Sbjct: 19 LHARRAVLALVATLGIL--AAGGAQAAQVTRFSPEGTVGQVRQVAIRFDEAMVPMGDVQA 76 Query: 61 ASPFDADCAVAGT---ARWADDKNWVYDFERDLPPGTRCSFTLRAEAKSVAGNSVGGKTR 117 +P C AGT ARW D KNWVYDF DLPPG RC+ +R +SVAG + GK Sbjct: 77 TAPAAVSCTGAGTGGQARWIDAKNWVYDFASDLPPGVRCTVRMRTGLRSVAGTAYAGKPE 136 Query: 118 FQFSTGGPAVSRVQPYSGAQIAEDQAFILFQNGPATEPSVRQHLYCEAEGINERIPAKAV 177 ++F TGGP V +P +G +I EDQ F L NG AT SVR+H +C+A+G+ ERIP + + Sbjct: 137 YRFETGGPTVVSSRP-AGGEIEEDQVFALRFNGAATAASVREHAWCQAQGLGERIPVRLL 195 Query: 178 GEADRKALL-----QQFAKGVDPASVTIVQCQQRLPNEAHVKLVWDRGIAAANAPAVVTS 232 +R A+L ++ AK P +V ++ CQQRLP A V+LV GIA + V T Sbjct: 196 AGKERDAVLDAIHWERIAKQA-PDAVHLLACQQRLPAAARVQLVLGAGIATPSG--VATR 252 Query: 233 QPQVFNFQVRSEFAASLSCQRENANAACSPILPVTLSFSAPVPRKLAEQVVMNATTGKIK 292 + F++ VR F AS SC+RE+A + C+P+ P+++SFS+PVPRKLAE VV+ +G Sbjct: 253 DERRFDYTVREPFTASFSCEREHAQSPCTPLRPMSVSFSSPVPRKLAESVVLKTPSGPRA 312 Query: 293 PTLEGD--KDEAVRELRFKPPFPEKSDFTISLPSGFKDEDGRTLANAGAFPLKSALADFP 350 P + D D +V L F PF EK+ FTI +P KD+ GRTLANA FPLK A A P Sbjct: 313 PQFDPDLAPDASVSALTFAAPFAEKAQFTIEVPRNLKDDSGRTLANADLFPLKVATASMP 372 Query: 351 PLAKFPAAPFGIIELNAD-----------PTLPVTLRRVEAGLQVRGKDGRAMPGQVADL 399 PLAKF AAPFG++E + P LPVTLR VEA L VRG RA G V L Sbjct: 373 PLAKFAAAPFGVVERFGELPRGKAPADYPPLLPVTLRNVEADLAVRGVQARA--GTVMKL 430 Query: 400 KVNGDKAVIAWLTRLNKYHE------------------KWGDPKK---VDTRSVSLLAKE 438 +V+ D AV+ W + + HE + +P+ ++TRSVSLL + Sbjct: 431 RVDDDTAVMQWFGLVRRMHEASYTRAELDAVLAGRSPYRVNNPRNAVSIETRSVSLLERA 490 Query: 439 SGAKKLDLPAQKDAKDGEWPFEVIGIPLKDPGFYVVELESQKLGASLLGKPQPMYVRTSA 498 G +KL +P K + D PFEV+GIPL +PGF+VVE+ S LG SLLGK PMYVRT+A Sbjct: 491 PGVQKLAVP--KPSGDAPRPFEVVGIPLPEPGFHVVEIASPMLGESLLGKRAPMYVRTAA 548 Query: 499 LVTNLSVHVKLGRA---------NGAVWVTRLDDAKPVADAEIRVSNCDGAQIWQGKTNA 549 LVTNL VH KLGR+ +G WVT LDD KPVADA + V +C G + +G+T+A Sbjct: 549 LVTNLGVHFKLGRSAGNEDDGSRSGLAWVTALDDGKPVADAAVAVRDCSGRLLGEGRTDA 608 Query: 550 SGVAMMPAL----EDACANRGYSPDNADKINGLFVSAR----KTDEKGRQDMAFALTSWN 601 SGV L E AC G S G FVSAR +G+ DMAF ++ WN Sbjct: 609 SGVVRFARLAAAPEGACEQNGLS--------GYFVSARIGVGHPQARGKADMAFVMSDWN 660 Query: 602 EGIESWRFNLPTDMDKSATVRATTVFDRTLFRAGETVSMKHVIRTETLQGFGLM-RKEDL 660 GIESWRFN+PTD + TVRA T+FDRTL RAGETVSMKHVIR ET QGF L L Sbjct: 661 RGIESWRFNVPTDTGTAPTVRAHTIFDRTLLRAGETVSMKHVIRAETAQGFALPPASRPL 720 Query: 661 PTRVRISHLGSGQQYQFPLTWR----GNKSAETTFVLPKQAKLGSYEVVLDQGKVDANAS 716 PTRV I H GSGQ Y+ PL WR G +SAE++F +P AKLG Y V L+ Sbjct: 721 PTRVVIRHEGSGQTYELPLQWRQTATGGRSAESSFQVPAAAKLGVYSVELET-------- 772 Query: 717 AEPPEQSDDGDYEGGYGRGTYVTGSFRVEEFRLPLMQG--RITPPKGAQVAVKEMPLDLQ 774 Q +G + G RG Y +GSFRVE FRLP++ G ++ G VA E+P+ ++ Sbjct: 773 -----QKGEGAQDNGGARG-YTSGSFRVEAFRLPVLAGTLQVAGKAGPMVAPAELPVGVE 826 Query: 775 LNYINGGAAANQAVQVSSLLRSRSLNIAGYDGFSFDAPRS-------------DE--DSN 819 ++Y++GG AA V+VS+LLR + ++ GYD FSF+ PR+ DE D++ Sbjct: 827 IHYLSGGGAAGLPVRVSALLRDKYVSFPGYDEFSFNPPRAQRESASGDEEMDEDEQGDAS 886 Query: 820 ADDQKIVADKLAITLDKNGAGRATISKLPALQRPQELLTEMTYSDPNGEVQTISNVTPLW 879 AD QK+VADKL +TLDKNG G T+ KLP ++ P++LL E ++DPNGE+QT+ P+W Sbjct: 887 ADSQKLVADKLPVTLDKNGNGTVTLRKLPKIEAPRDLLLEAGFADPNGEIQTLRQTVPVW 946 Query: 880 PSAVVVGLRTGNWVSVKKKLTLTAVTLNTAGQPQAGVPVEIRGTARKTNSHRKRMVGGFY 939 P+AVV G+RT WVSVK+KL + V L+ G+P A PV+I AR T S RKR+VGGFY Sbjct: 947 PAAVVAGIRTDGWVSVKQKLAVHGVVLDVNGKPVADAPVKINARARITTSARKRVVGGFY 1006 Query: 940 AYENDETKQDLGKLCSGKSDQHGMFTCDTELSEAGNVELIASAKDGNGNAAAARSSVWVT 999 Y+N +DLG +C ++D G CD L +AG +EL+ASA+D +G A A S+VWVT Sbjct: 1007 RYDNRSETRDLGTVCETRTDAQGRARCDVALEQAGQIELVASARDKDGRTAQAASTVWVT 1066 Query: 1000 GRGEVWFDGENQDRIDILPEKKNYQPGETANFQVRMPFRSATALVAVEREGVIDTRVVQL 1059 +GE+WF GEN DRID+LPEKK+Y PG+TA FQVRMPFR ATALVAVEREG+ T+VV+L Sbjct: 1067 RQGELWFGGENHDRIDLLPEKKSYAPGDTAVFQVRMPFRHATALVAVEREGIYQTQVVEL 1126 Query: 1060 SGQDPTISVPMKAEYGPNVYVSVLAVRGRMREVPWYSFFIWGWKEPINWWHEF----REY 1115 G DPT+ V +K E+GPNVYVSVLA+RGR+ EVPWYSFF WGW++P WW F REY Sbjct: 1127 HGSDPTVRVQVKPEWGPNVYVSVLALRGRLHEVPWYSFFTWGWRQPGEWWRAFRSEGREY 1186 Query: 1116 QGPGPIVDLSKPAWKFGIAEVNVGDAGHRLQVAVSTDKPTYPIRAIAKVQVQVKLPNGKP 1175 P +VDLSKPA++ G+AE+ VG+AGHRL V V+ DK +YP+R A+V +QVKLP GKP Sbjct: 1187 AAPTALVDLSKPAFRLGLAEIRVGNAGHRLDVTVTPDKASYPVRGKARVAIQVKLPEGKP 1246 Query: 1176 AAGGEFALAAVDEALLELQPNGSWDVLHAMLQRRSYGVETSTAQMQVVGKRHYGKKATPA 1235 AA GE ALAAVD+ALLEL PN SWD+L AMLQRR YGVETSTAQM+++G+RHYG+KA PA Sbjct: 1247 AANGEVALAAVDQALLELMPNTSWDLLDAMLQRRGYGVETSTAQMEIIGRRHYGRKAVPA 1306 Query: 1236 GGGGGRAPTRELFDTLLVWKPNVTLDAEGRAQLDVPLNDALTSFRIVAIAENGISDFGTG 1295 GGGGG++PTRELFDTLLVW P V LDAEGRA ++VPLND+LTSFRIVA+A+ G+ FGTG Sbjct: 1307 GGGGGKSPTRELFDTLLVWNPRVQLDAEGRASIEVPLNDSLTSFRIVAVADLGLGRFGTG 1366 Query: 1296 SISIRSTQDVQVISGLPPLVREGDSFNGAVTVRNTTTHDMTIKVAARAQGGTATSTLTLP 1355 S +I +TQD+QVISGLP LVRE D + T+RNTT MT++ +AR G + +LP Sbjct: 1367 SATIAATQDLQVISGLPLLVREDDRYRAMFTLRNTTRRAMTVQASAR--GTLLGNEASLP 1424 Query: 1356 EREVKIAAGQSAEVMWPVQTPEGI-----NQLAWEISAQEQGGQKARDAMKFTQRVVPAV 1410 + V+I AG++ E+ W V P + + WE+ A EQG A D +K +Q++VPAV Sbjct: 1425 AQTVQIPAGEAREIGWDVTAPALLAYSRSGTVMWEVQASEQGTGGAADRIKVSQQIVPAV 1484 Query: 1411 PVTVQQATLFQLDKNAALDVARPADSLPG-----RGGLAISLKPSLAGGSDALTRYFVNY 1465 PVTVQQATL Q+ + ++ + P +L RGGL ++ + SLAGG + +F NY Sbjct: 1485 PVTVQQATLAQVSPSLSVPLKAPPGALADPAGKVRGGLQVNFQSSLAGGMPGVREWFRNY 1544 Query: 1466 PFACLEQKTSKAIGLRDEAAWQKIVADLPTYLDGDGLAYYFPPSDSGARRGSDTLTAYLL 1525 PF CLEQ+ SKAIGL D AAW ++ LP+YLD +GLA YFP + G GS+ LTAYLL Sbjct: 1545 PFTCLEQRASKAIGLNDTAAWDALMTQLPSYLDANGLASYFPLNADG-DFGSEVLTAYLL 1603 Query: 1526 AATNEAGYA-----IPQASRDKMLDGLAAFVEGKVMRDFWSP---QKDLDVRKLAALEAL 1577 A T+EA A IP A R +M GL FVEG++ RD W+P + LD RKLAALEAL Sbjct: 1604 AVTDEAARAGLALRIPDAQRTQMERGLTDFVEGRIRRDSWAPVAGTQYLDARKLAALEAL 1663 Query: 1578 SRYNRVQPAMLGSLQINPNVWPTSGLLDWIAILQRVPAIPDRQKKLDEADQILRARLNFQ 1637 SR Q MLGS+QI P WPTS LLDW +L R+ IP R+++L EA Q+LR+RL Q Sbjct: 1664 SRTGHAQARMLGSIQILPAQWPTSALLDWTLLLTRMQDIPQREQRLAEAQQLLRSRLTVQ 1723 Query: 1638 GTRMGFSNEEGDYWWWLMSSGDANANRLILLELNNPAWREDMPRLIAGAIGRQQRGHWST 1697 GTR+ FS E D WWW+M+ GD NA RL+ L P W+E+ P+L G +GRQ G W T Sbjct: 1724 GTRLAFSTERNDNWWWMMAGGDTNAARLLALASELPGWKEEAPQLATGLLGRQVHGAWGT 1783 Query: 1698 TTANVWGSLALEKFARKFESEPVTGATRATLEQNGASAATQSLAWSGAPNG-----GKLQ 1752 TTAN WG LA+ +F++ FE PV G TRA++ + A+ A++S W+ A G L Sbjct: 1784 TTANAWGMLAVTRFSQAFEKTPVAGTTRASV--SNAADASRSFDWARAQRTDGVAQGSLD 1841 Query: 1753 LPWPEGNAQGGSVRLAQEGNGKPWVTLQSLAAVPLKQPFAAGYRITRKVEAIEQKQAGVY 1812 LPWP G A GG++++ G G PW T+++LAAVP+ P AAGYRI R V EQ G + Sbjct: 1842 LPWPTG-ADGGTLQVEHAGAGHPWATVRALAAVPVTAPLAAGYRIRRTVTPQEQAVQGKW 1900 Query: 1813 TRGDVLRVTLDIDAQAEMTWVVVSDPVPGGATLLGSGLGRDSAIAQGKQDAPRERGMGWL 1872 +RGDV RV L+IDAQA+MTWVVVSDPVP GAT+LGSGLGRDS IA + R +G W Sbjct: 1901 SRGDVYRVKLEIDAQADMTWVVVSDPVPAGATILGSGLGRDSTIATRGE---RRKGAAWP 1957 Query: 1873 AYEERSFEAYRAYYEAMPKGRTSISYTVRLNNAGEFNLPPTRVEAMYAPEMFGEVPNGKL 1932 AY ER+ +AYR Y+ +PKG S+ YTVRLNNAG+F LPPTRVEA+YAP++FG PN +L Sbjct: 1958 AYTERTPQAYREYFGYLPKGTVSVEYTVRLNNAGDFALPPTRVEALYAPDVFGVAPNARL 2017 Query: 1933 VVKA 1936 V A Sbjct: 2018 AVGA 2021 >C5CRS4.1 C5CRS4_VARPS Alpha-2-macroglobulin domain protein Length = 2012 Score = 1958 bits (5073), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1038/2017 (51%), Positives = 1364/2017 (67%), Gaps = 136/2017 (6%) Query: 29 VQSFSPQGEVQRIRQVRARFSESMVKFGDPKAASPFDADCAVA----GTARWADDKNWVY 84 + S +PQGEV R+RQV A+F + V FGDPKA +P C A GT RW D K WVY Sbjct: 25 ITSLTPQGEVARVRQVVAKFDQPAVNFGDPKAPAPLAVSCTDAQAGKGTGRWTDAKAWVY 84 Query: 85 DFERDLPPGTRCSFTLRAEAKSVAGNSVGGKTRFQFSTGGPAVSRVQPYSGAQIAEDQAF 144 DFE DLPPG RC+ T A K +G + G R+QF++GGP V P S +I E Q F Sbjct: 85 DFENDLPPGVRCTVTRIAGFKPASGGELTGPERYQFNSGGPFVRNHMPGSYGRIDEQQMF 144 Query: 145 ILFQNGPATEPSVRQHLYCEAEGINERIPAKAVGEADRKALLQQFAK----GVDPASVTI 200 +L NG AT SVRQ+++C A+GI ERIP + + R LL+ F + DP Sbjct: 145 VLELNGAATVESVRQNVWCAADGIGERIPVRLLEGEQRAGLLKAFGREAEAAKDPLRFIA 204 Query: 201 VQCQQRLPNEAHVKLVWDRGIAAANAPAVVTSQPQVFNFQVRSEFAASLSCQRENANAAC 260 +QC + L + V++V+ +G+A + V + + +FQVR FA S SC+RENA AAC Sbjct: 205 LQCNRTLTPGSKVQIVYGKGVATPSG--VANNVERRLSFQVREPFAVSFSCERENAQAAC 262 Query: 261 SPILPVTLSFSAPVPRKLAEQVVMNATTGKIKPTLEGD-----KDEAVRELRFKPPFPEK 315 P+ P+ L F+APV RK+A Q+ + I TLE D +D+ V F PPF E Sbjct: 263 LPLRPMQLQFNAPVTRKMASQIQLKGGGKSIAATLENDGGTPSEDDVVSAASFSPPFAED 322 Query: 316 SDFTISLPSGFKDEDGRTLANAGAFPLKSALADFPPLAKFPAAPFGIIELNADP----TL 371 + F+I LP+ F+D GR LA+ G+FPLK A PPLAKF A+PFG++E A+P + Sbjct: 323 TKFSIELPAKFEDASGRPLASPGSFPLKVATGAMPPLAKFAASPFGVVERLAEPGTPAMM 382 Query: 372 PVTLRRVEAGLQVRGKDGRAMPGQVADLKVNGDKAVIAWLTRLNKYHE------------ 419 PVT+RRVE L V+ PG+V+D+ D +IAW ++ +Y E Sbjct: 383 PVTVRRVEPALMVQA----LTPGKVSDMNPKTDAEIIAWFRKVRRYDEYTVSREQARKDV 438 Query: 420 --------KWGDPKKVDTRSVSLLAKESGAKKLDLPAQKDAKDGE-WPFEVIGIPLKDPG 470 + + V +R +SLLA + G K LD+P A+ G+ PFEVIGIPL PG Sbjct: 439 KGALPAIIETSERTHVQSRMLSLLAGQPGVKALDMP---KAESGDPRPFEVIGIPLT-PG 494 Query: 471 FYVVELESQKLGASLL----GKPQPMYVRTSALVTNLSVHVKLGRANGAVWVTRLDDAKP 526 F+V+E+ SQKLG +LL G + MYVRT+AL TNL+VH KLGR N WVT LD K Sbjct: 495 FHVLEIASQKLGDALLDERYGANRTMYVRTTALATNLAVHFKLGRENSMAWVTTLDKGKV 554 Query: 527 VADAEIRVSNCDGAQIWQGKTNASGVAMMPALE-DACANRGYSPDNADKINGLFVSARKT 585 V +AE+RVS+C G + G T+A+G+ + + DA G NA FVSAR Sbjct: 555 VPNAEVRVSDCRGVAVASGTTDANGIVNLTGVAPDAPNCNGPDEYNA---GAWFVSARAK 611 Query: 586 DEKGRQDMAFALTSWNEGIESWRFNLPTDMDKSATVRATTVFDRTLFRAGETVSMKHVIR 645 D+KG +D+AF + W GIE WRFN+PT + A T+FDRTL RAGETVSMKH+IR Sbjct: 612 DDKGVEDLAFTWSDWQRGIEPWRFNVPTSLQAEPDRVAHTIFDRTLLRAGETVSMKHLIR 671 Query: 646 TETLQGFGLMRKEDLPTRVRISHLGSGQQYQFPLTWR----GNKSAETTFVLPKQAKLGS 701 T+T +GFGL E+ P + I+H GSGQ++ PL WR G SAE +F +P AKLG Sbjct: 672 TQTSKGFGL--PENRPDTLVITHTGSGQRFTQPLAWRKTPTGGLSAENSFAIPPAAKLGL 729 Query: 702 YEVVLDQGK-VDANASAEPPEQSDDGDYEGGYGRGTYVTGSFRVEEFRLPLMQGRITPP- 759 YEV+L GK DAN+ E+ + D EGGY R ++ TG FRVEEFRLP+++GRI P Sbjct: 730 YEVMLRSGKGKDANSGNA--EEEVEVDDEGGYNR-SFSTGQFRVEEFRLPVLEGRIAPTD 786 Query: 760 KGAQVAVKEMPLDLQLNYINGGAAANQAVQVSSLLRSRSLNIAGYDGFSFDAPR------ 813 K V+V +P D+Q+NY+ GG AAN V+VS+++R +SL+ + ++ FSF PR Sbjct: 787 KKPLVSVASVPTDVQINYVAGGGAANLPVRVSAMVRGKSLSFSDHEAFSFSPPRVQAESS 846 Query: 814 ------------SDEDSN-ADDQKIVADKLAITLDKNGAGRATISKLPALQRPQELLTEM 860 ++ED N A D +++ADKL +TL+K+GAG+ TI K+P ++ +ELL E Sbjct: 847 QAPAAAAADTAGAEEDINSASDTRVIADKLPLTLNKDGAGKLTIDKVPKVKAARELLLEA 906 Query: 861 TYSDPNGEVQTISNVTPLWPSAVVVGLRTGNWVSVKKKLTLTAVTLNTAGQPQAGVPVEI 920 TY+DPNGEVQTI + LWP++V+ G++T WVS +KL A+ L+ +G+PQAGV + + Sbjct: 907 TYADPNGEVQTIRSTQTLWPASVIAGIKTEGWVSTSQKLKYQALALDLSGKPQAGVTLNV 966 Query: 921 RGTARKTNSHRKRMVGGFYAYENDETKQDLGKLCSGKSDQHGMFTCDTELSEAGNVELIA 980 R AR T + RKRMVGGFY Y+N +D+G +CSGKSD G+ C++EL EAG VEL+A Sbjct: 967 RAVARITTTSRKRMVGGFYTYDNKTETKDIGTVCSGKSDARGLLLCESELKEAGEVELVA 1026 Query: 981 SAKDGNGNAAAARSSVWVTGRGEVWFDGENQDRIDILPEKKNYQPGETANFQVRMPFRSA 1040 SA D G + A SSV+VT +GE+WF GE+ DRID+LPEKK+YQPGE A FQVR PFR A Sbjct: 1027 SATDSEGRDSRAASSVYVTKQGELWFGGEDNDRIDVLPEKKSYQPGEIAKFQVRSPFRFA 1086 Query: 1041 TALVAVEREGVIDTRVVQLSGQDPTISVPMKAEYGPNVYVSVLAVRGRMREVPWYSFFIW 1100 TALV+VEREG+I+T VVQL G+DPT+S+ ++ E+GPN YVSVLA+RGR+REVPWYSFF W Sbjct: 1087 TALVSVEREGIIETHVVQLDGKDPTVSLQVRPEWGPNAYVSVLALRGRLREVPWYSFFTW 1146 Query: 1101 GWKEPINWWHEF----REYQGPGPIVDLSKPAWKFGIAEVNVGDAGHRLQVAVSTDKPTY 1156 G+K P WW F +EY P +VDLSKPA++ G+AE+ VG H++ V V++DKP+Y Sbjct: 1147 GFKAPREWWTAFWYEGKEYVAPTAMVDLSKPAYRLGMAEIRVGTRAHQINVTVTSDKPSY 1206 Query: 1157 PIRAIAKVQVQVKLPNGKPAAGGEFALAAVDEALLELQPNGSWDVLHAMLQRRSYGVETS 1216 P+R+ A++ + KLP+GKPAAG E ALAAVD+ALLEL PN SW++L+AMLQRRS+GV TS Sbjct: 1207 PVRSKAQITISAKLPDGKPAAGAEVALAAVDQALLELMPNDSWNLLNAMLQRRSWGVSTS 1266 Query: 1217 TAQMQVVGKRHYGKKATPAGGGGGRAPTRELFDTLLVWKPNVTLDAEGRAQLDVPLNDAL 1276 TAQM++VG+RHYG+KA PAGGGGG+ TREL DTLL+W P V LDA G+A + VPLNDAL Sbjct: 1267 TAQMEIVGRRHYGRKAVPAGGGGGKGQTRELLDTLLLWNPKVVLDANGQAVVTVPLNDAL 1326 Query: 1277 TSFRIVAIAENGISDFGTGSISIRSTQDVQVISGLPPLVREGDSFNGAVTVRNTTTHDMT 1336 T+F+IVA+A++G S FGTG SI++TQD+Q+ISGLPPLVRE D F +T+RNTT M Sbjct: 1327 TTFKIVAVADSGTSLFGTGQASIQATQDLQIISGLPPLVREDDQFRAQITLRNTTQKPMK 1386 Query: 1337 IKVAARAQGGTATSTLTLPEREVKIAAGQSAEVMWPVQTPEGINQ-----LAWEISAQEQ 1391 ++ A RA + LTL + V I AG++ EV W V P + Q + WEI A++ Sbjct: 1387 VEAAPRA------TLLTLAPQTVDIPAGEAREVAWTVTAPAQLAQTRAEAILWEIEAKDT 1440 Query: 1392 GGQKARDAMKFTQRVVPAVPVTVQQATLFQLDKNAALDVARPADSLPGRGGLAISLKPSL 1451 G ARDA+K QR++P+VP+TVQQATL Q+D +DVA PAD+LPGRGGL +SL+P L Sbjct: 1441 LG-GARDALKVRQRIIPSVPLTVQQATLVQIDGPFTIDVAPPADALPGRGGLKLSLQPKL 1499 Query: 1452 AGGSDALTRYFVNYPFACLEQKTSKAIGLRDEAAWQKIVADLPTYLDGDGLAYYFPPSDS 1511 A G + +F NYPF CLEQKTSK++GLRD WQ ++A LPTYLD DGLA YFPP D Sbjct: 1500 AEGLPGVRDWFANYPFICLEQKTSKSVGLRDAKMWQGVLAQLPTYLDSDGLASYFPPRDG 1559 Query: 1512 GARRGSDTLTAYLLAATNEA-----GYAIPQASRDKMLDGLAAFVEGKVMRDFWSPQKDL 1566 + RGSD LT+YLLAAT+EA +A+P A+R M GL AFVEG++ R+FWSP+KDL Sbjct: 1560 ESNRGSDILTSYLLAATHEAAALNPAFALPDAARAPMESGLIAFVEGRIQREFWSPRKDL 1619 Query: 1567 DVRKLAALEALSRYNRVQPAMLGSLQINPNVWPTSGLLDWIAILQRVPAIPDRQKKLDEA 1626 DVRKLAALEALSRY + +MLGS+ I PN WPTS ++DW+ IL+RV +P RQ++L+EA Sbjct: 1620 DVRKLAALEALSRYGTAKGSMLGSITIAPNQWPTSAVIDWLNILKRVQDVPQRQQRLEEA 1679 Query: 1627 DQILRARLNFQGTRMGFSNEEGDYWWWLMSSGDANANRLILLELNNPAWREDMPRLIAGA 1686 + +L+ARL++QGT++ FS E+ DYWWWLM++GD N RL+L +++PAW++D+ +L G Sbjct: 1680 NNVLKARLSYQGTKLVFSTEQDDYWWWLMTNGDVNTARLLLSVMDDPAWKDDIGKLANGF 1739 Query: 1687 IGRQQRGHWSTTTANVWGSLALEKFARKFESEPVTGATRATL----------------EQ 1730 IGRQQ G W TTTAN+WG LALEKF++ FES PV G T ATL Sbjct: 1740 IGRQQNGAWHTTTANLWGGLALEKFSKVFESTPVAGVTAATLGAVKAQVDWRSVERVKTT 1799 Query: 1731 NGASAATQSLAWSGAPNGGKLQ-----LPW---PEGNAQGGSVRLAQEGNGKPWVTLQSL 1782 + A A QS + + G L+ LPW P G ++ + Q+G+GKPW+T+QS+ Sbjct: 1800 DAAGAPNQSTFFGAPASPGNLKNNSMFLPWAASPAGTPVRDTLLVTQQGSGKPWLTMQSI 1859 Query: 1783 AAVPLKQPFAAGYRITRKVEAIEQKQAGVYTRGDVLRVTLDIDAQAEMTWVVVSDPVPGG 1842 AAV LK PFAAGY I + + +EQ AG YTRGDVLRVT++++A +MTWVVVSDP+PGG Sbjct: 1860 AAVQLKAPFAAGYAIKKTITPVEQATAGKYTRGDVLRVTVEVNASTDMTWVVVSDPIPGG 1919 Query: 1843 ATLLGSGLGRDSAIA-QGKQDAPRERGMGWLAYEERSFEAYRAYYEAMPKGRTSISYTVR 1901 AT+LG+GLGRDS IA QG+ R+ G GWLA+EERSFEA+R+YYE +PKG I YTVR Sbjct: 1920 ATILGTGLGRDSQIATQGE----RKSGAGWLAFEERSFEAFRSYYEYLPKGVVKIEYTVR 1975 Query: 1902 LNNAGEFNLPPTRVEAMYAPEMFGEVPNGKLVVKAAQ 1938 LNN G+F LPP+RVEAMYAPEMFGE PN ++ V+AA+ Sbjct: 1976 LNNVGDFALPPSRVEAMYAPEMFGETPNARVKVEAAK 2012 >E6V2H6.1 E6V2H6_VARPD Alpha-2-macroglobulin domain protein Length = 2008 Score = 1956 bits (5067), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1038/2014 (51%), Positives = 1355/2014 (67%), Gaps = 134/2014 (6%) Query: 29 VQSFSPQGEVQRIRQVRARFSESMVKFGDPKAASPFDADCAVA----GTARWADDKNWVY 84 + S +PQGEV R+RQ+ A+F ++ V FGDPKA +P C+ A GT RW D K WVY Sbjct: 25 ITSLTPQGEVARVRQIVAKFDQAAVNFGDPKAPAPLSVSCSDAQAGKGTGRWTDAKAWVY 84 Query: 85 DFERDLPPGTRCSFTLRAEAKSVAGNSVGGKTRFQFSTGGPAVSRVQPYSGAQIAEDQAF 144 DFE DLPPG RC+ T K AG + G R+QF++GGP V P + + I E Q F Sbjct: 85 DFENDLPPGVRCTVTRIPTFKPSAGGELTGPERYQFNSGGPFVRSYMPGTYSPIDEQQMF 144 Query: 145 ILFQNGPATEPSVRQHLYCEAEGINERIPAKAVGEADRKALLQQFAKGV----DPASVTI 200 +L NG AT SVRQ+++C A+G+ ERIP K + R +L+ F++ +P Sbjct: 145 VLELNGAATLESVRQNVWCSADGVGERIPVKLLDGEQRTGVLKAFSRDKAAEKEPLRFIT 204 Query: 201 VQCQQRLPNEAHVKLVWDRGIAAANAPAVVTSQPQVFNFQVRSEFAASLSCQRENANAAC 260 +QC + L V++V+ +G+A + V + + +++VR FA S +C+RENA +AC Sbjct: 205 MQCNRTLTPGTKVQVVYGKGVATPSG--VANNVERRLDYRVREPFAVSFTCERENAQSAC 262 Query: 261 SPILPVTLSFSAPVPRKLAEQVVMNATTGKIKPTLEGD-----KDEAVRELRFKPPFPEK 315 P+ P+ L F+APV RKLA Q+ + IK L+ D D+ V + F PP E Sbjct: 263 LPLRPMQLQFNAPVTRKLASQIELKGDGKTIKAKLDNDGGTQSDDDVVNNVSFGPPLAES 322 Query: 316 SDFTISLPSGFKDEDGRTLANAGAFPLKSALADFPPLAKFPAAPFGIIELNADP----TL 371 ++I LPS F+D GR LA G FPLK A PPLAKF A+PFG+IE A+P + Sbjct: 323 MQYSIELPSKFEDASGRPLATPGTFPLKVATGAMPPLAKFAASPFGVIERLAEPDTPAMM 382 Query: 372 PVTLRRVEAGLQVRGKDGRAMPGQVADLKVNGDKAVIAWLTRLNKYHE------------ 419 PVT+RRVE L V PG+V+D+ D +IAW ++ +Y Sbjct: 383 PVTVRRVEPQLLVNA----LTPGKVSDMNPKTDAEIIAWFRKVRRYDSYTVSREQARKDV 438 Query: 420 KWGDPKKVD--------TRSVSLLAKESGAKKLDLPAQKDAKDGEWPFEVIGIPLKDPGF 471 K P +D TR +SLLA + G K LD+P + DA D PFEVIGIPL PGF Sbjct: 439 KGALPPVIDKDDRTSLQTRMLSLLAGQPGVKALDMP-KSDAGDPR-PFEVIGIPLT-PGF 495 Query: 472 YVVELESQKLGASLLGKPQP----MYVRTSALVTNLSVHVKLGRANGAVWVTRLDDAKPV 527 +V+E+ SQKLG +LL + P MYVRT+AL TNL+VH KLGR N WVT LD K V Sbjct: 496 HVLEIASQKLGEALLDERYPAGRTMYVRTTALATNLAVHFKLGRENSMAWVTTLDKGKVV 555 Query: 528 ADAEIRVSNCDGAQIWQGKTNASGVAMMPALEDACANRGYSPDNADKINGLFVSARKTDE 587 A AE+RVS+CDG + G T+A+G+ + + A P+ D FVSAR DE Sbjct: 556 AGAEVRVSSCDGKAVATGTTDANGIVTLQGVSPQ-APSCNGPNEYDS-GAWFVSARAKDE 613 Query: 588 KGRQDMAFALTSWNEGIESWRFNLPTDMDKSATVRATTVFDRTLFRAGETVSMKHVIRTE 647 KG +D+AF + W GIE WRFN+PT++ A T+FDRTL RAGETVSMK +IRT+ Sbjct: 614 KGVEDLAFTFSDWQRGIEPWRFNVPTNLQPEPDRIAHTIFDRTLLRAGETVSMKSLIRTQ 673 Query: 648 TLQGFGLMRKEDLPTRVRISHLGSGQQYQFPLTWR----GNKSAETTFVLPKQAKLGSYE 703 T +GFGL E+ P + I+H GSGQ++ PL WR G SAE +F +P AKLG YE Sbjct: 674 TSKGFGL--PENRPDTLVITHTGSGQRFTQPLAWRKTATGGLSAENSFAIPPAAKLGVYE 731 Query: 704 VVLDQGK-VDANASAEPPEQSDDGDYEGGYGRGTYVTGSFRVEEFRLPLMQGRITPP-KG 761 V+L G DAN +E E + G ++ TG FRVEEFRLP+++GRI+P K Sbjct: 732 VMLRSGGGKDANGDSEEGEGDEGGGSR------SFSTGMFRVEEFRLPVLEGRISPTEKK 785 Query: 762 AQVAVKEMPLDLQLNYINGGAAANQAVQVSSLLRSRSLNIAGYDGFSFDAPRSD------ 815 VA +P D+Q+NY+ GG AAN V+VS+++R +SL+ + YD FSF+ PR+D Sbjct: 786 PLVAATSVPTDVQINYVAGGGAANLPVRVSAMVRGKSLSFSDYDAFSFNPPRADQGDGTQ 845 Query: 816 -----------EDSN-ADDQKIVADKLAITLDKNGAGRATISKLPALQRPQELLTEMTYS 863 ED N A D +++ADKL +TL+K+GAG+ TI K+P ++ +ELL E TY+ Sbjct: 846 AAAAADTAGADEDINSASDTRVIADKLPLTLNKDGAGKVTIDKVPKVKSARELLLEATYA 905 Query: 864 DPNGEVQTISNVTPLWPSAVVVGLRTGNWVSVKKKLTLTAVTLNTAGQPQAGVPVEIRGT 923 DPNGEVQTI + LWP++V+ G++T WVS +KL A+ L+ G+PQAGV + +R Sbjct: 906 DPNGEVQTIRSTQTLWPASVIAGIKTEGWVSTSQKLKFQALALDLTGKPQAGVTLNVRAV 965 Query: 924 ARKTNSHRKRMVGGFYAYENDETKQDLGKLCSGKSDQHGMFTCDTELSEAGNVELIASAK 983 AR T + RKRMVGGFY Y+N +D+G +CSGKSD G+ C++EL EAG VELIASA Sbjct: 966 ARITTTSRKRMVGGFYTYDNKTETKDIGTVCSGKSDARGLLLCESELKEAGEVELIASAT 1025 Query: 984 DGNGNAAAARSSVWVTGRGEVWFDGENQDRIDILPEKKNYQPGETANFQVRMPFRSATAL 1043 DG+G A A SSV+VT +GE+WF GE+ DRID+LPEKK+YQPGE A FQVR PFR ATAL Sbjct: 1026 DGDGRDAKAVSSVYVTKQGELWFGGEDNDRIDVLPEKKSYQPGEVAKFQVRSPFRFATAL 1085 Query: 1044 VAVEREGVIDTRVVQLSGQDPTISVPMKAEYGPNVYVSVLAVRGRMREVPWYSFFIWGWK 1103 V+VEREG+I+T VVQL G+DPT+++ +K E+GPN Y+SVLA+RGR+REVPWYSFF WG+K Sbjct: 1086 VSVEREGIIETHVVQLDGKDPTVTLQVKPEWGPNAYISVLALRGRLREVPWYSFFTWGFK 1145 Query: 1104 EPINWWHEF----REYQGPGPIVDLSKPAWKFGIAEVNVGDAGHRLQVAVSTDKPTYPIR 1159 P WW F +EY P +VDLSKPA++ G+AE+ VG H+L V V++DKP+YPIR Sbjct: 1146 APREWWTAFWYEGKEYVAPTAMVDLSKPAYRLGMAEIRVGTRAHQLDVTVTSDKPSYPIR 1205 Query: 1160 AIAKVQVQVKLPNGKPAAGGEFALAAVDEALLELQPNGSWDVLHAMLQRRSYGVETSTAQ 1219 + A++ + KLP+GKPAAG E ALAAVD+ALLEL PN SW++L+AMLQRRS+GV TSTAQ Sbjct: 1206 SKAQITITAKLPDGKPAAGAEVALAAVDQALLELMPNDSWNLLNAMLQRRSWGVSTSTAQ 1265 Query: 1220 MQVVGKRHYGKKATPAGGGGGRAPTRELFDTLLVWKPNVTLDAEGRAQLDVPLNDALTSF 1279 M++VG+RHYG+KA PAGGGGG+ TREL DTLLVW P V LDA G+A + VPLNDALT+F Sbjct: 1266 MEIVGRRHYGRKAVPAGGGGGKGQTRELLDTLLVWNPKVVLDANGQAVVTVPLNDALTTF 1325 Query: 1280 RIVAIAENGISDFGTGSISIRSTQDVQVISGLPPLVREGDSFNGAVTVRNTTTHDMTIKV 1339 +IVA+A++G S FGTG SI++TQD+Q+ISGLPPLVRE D F +T+RNTT M ++ Sbjct: 1326 KIVAVADSGTSLFGTGQASIQATQDLQIISGLPPLVREDDQFRAQITLRNTTQKPMKVEA 1385 Query: 1340 AARAQGGTATSTLTLPEREVKIAAGQSAEVMWPVQTPEGINQ-----LAWEISAQEQGGQ 1394 RA + LTL + V I AG++ EV W V P + Q + WEI A++ G Sbjct: 1386 TPRA------TLLTLETQTVDIPAGEAREVAWTVTAPAQLAQTRAEAILWEIEAKDTLG- 1438 Query: 1395 KARDAMKFTQRVVPAVPVTVQQATLFQLDKNAALDVARPADSLPGRGGLAISLKPSLAGG 1454 ARDA+K QR+VP+VP+TVQQATL Q+D LDVA PAD+LPGRGGL +SL+P LA G Sbjct: 1439 GARDALKVRQRIVPSVPLTVQQATLVQIDGPFTLDVAPPADALPGRGGLKLSLQPKLAEG 1498 Query: 1455 SDALTRYFVNYPFACLEQKTSKAIGLRDEAAWQKIVADLPTYLDGDGLAYYFPPSDSGAR 1514 + +F NYPF CLEQKTSK++GLRD WQ ++A LPTYLDGDGLA YFPP D A Sbjct: 1499 LPGVRDWFANYPFICLEQKTSKSVGLRDAKMWQGVLATLPTYLDGDGLANYFPPRDGEAN 1558 Query: 1515 RGSDTLTAYLLAATNEA-----GYAIPQASRDKMLDGLAAFVEGKVMRDFWSPQKDLDVR 1569 RGSD LT+YLLAATNEA +A+ R M GL AFVEG++ R+FWSP+KDLDVR Sbjct: 1559 RGSDILTSYLLAATNEAAQLNPAFALADDVRAPMESGLIAFVEGRITREFWSPRKDLDVR 1618 Query: 1570 KLAALEALSRYNRVQPAMLGSLQINPNVWPTSGLLDWIAILQRVPAIPDRQKKLDEADQI 1629 KLAALEALSRY + + +MLGS+ I PN WPTS ++DW+ IL+RV +P RQ++LDEA+ + Sbjct: 1619 KLAALEALSRYGKAKGSMLGSITIAPNQWPTSAVIDWLNILKRVNDVPQRQQRLDEANNV 1678 Query: 1630 LRARLNFQGTRMGFSNEEGDYWWWLMSSGDANANRLILLELNNPAWREDMPRLIAGAIGR 1689 L+ARL++QGT++ FS E+ DYWWWLM++GD N RL+L +++P+W++D+ +L G IGR Sbjct: 1679 LKARLSYQGTKLIFSTEQDDYWWWLMTNGDVNTARLLLSVMDDPSWKDDIGKLANGFIGR 1738 Query: 1690 QQRGHWSTTTANVWGSLALEKFARKFESEPVTGATRATL---------------EQNGAS 1734 QQ G W TTTAN+WG LALEKF++ FES PV G T ATL + + A+ Sbjct: 1739 QQNGAWHTTTANLWGGLALEKFSKVFESTPVAGVTAATLGAVKAQVNWSQVERVKTSDAA 1798 Query: 1735 AATQSLAWSGAP-NGGKLQ-----LPW---PEGNAQGGSVRLAQEGNGKPWVTLQSLAAV 1785 A + GAP + G L+ LPW P G ++ + Q+G GKPW+TLQS+AAV Sbjct: 1799 GAPNQTTFFGAPASPGNLKNNTMFLPWAASPSGAPVRDTLLVTQQGTGKPWLTLQSIAAV 1858 Query: 1786 PLKQPFAAGYRITRKVEAIEQKQAGVYTRGDVLRVTLDIDAQAEMTWVVVSDPVPGGATL 1845 LK PFAAGY I + + +EQ AG YTRGDVLRVTL+++A A+MTWVV+SDP+PGGAT+ Sbjct: 1859 QLKAPFAAGYAIKKTITPVEQATAGKYTRGDVLRVTLEVNASADMTWVVISDPIPGGATI 1918 Query: 1846 LGSGLGRDSAIA-QGKQDAPRERGMGWLAYEERSFEAYRAYYEAMPKGRTSISYTVRLNN 1904 LG GLGRDS IA QG+ ++ G GW A+EERSFEA+R+YYE +PKG + YTVRLNN Sbjct: 1919 LGGGLGRDSQIATQGE----KKSGAGWAAFEERSFEAFRSYYEYLPKGVVKMEYTVRLNN 1974 Query: 1905 AGEFNLPPTRVEAMYAPEMFGEVPNGKLVVKAAQ 1938 G+F LPP+RVEAMYAPEMFGE PN ++ V+AA+ Sbjct: 1975 VGDFALPPSRVEAMYAPEMFGEAPNARVKVEAAK 2008 >C5T8V6.1 C5T8V6_ACIDE Alpha-2-macroglobulin domain protein Length = 1986 Score = 1948 bits (5047), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1030/2012 (51%), Positives = 1339/2012 (66%), Gaps = 155/2012 (7%) Query: 29 VQSFSPQGEVQRIRQVRARFSESMVKFGDPKAASPFDADC----AVAGTARWADDKNWVY 84 + SFSPQGEV R+RQ+ A+F + V FGDPKA +P C A GT RW ++ WV+ Sbjct: 24 ISSFSPQGEVARVRQMVAKFDTAAVNFGDPKAPAPVSLSCSDATATRGTGRWTSEREWVF 83 Query: 85 DFERDLPPGTRCSFTLRAEAKSVAGNSVGGKTRFQFSTGGPAVSRVQPYSGAQIAEDQAF 144 DF+ DLPPG RC+ T+++ KS AG + G T +QF++GGP V ++P + +I E+Q F Sbjct: 84 DFDNDLPPGVRCTVTVKSGFKSAAGALLTGATSYQFNSGGPFVQNIRPGTYQEIDEEQFF 143 Query: 145 ILFQNGPATEPSVRQHLYCEAEGINERIPAKAVGEADRKALLQQFA----KGVDPASVTI 200 +L NGPA SV+ +++C EG+ ER+P + + A R +L+ +P Sbjct: 144 VLQLNGPAAVASVQANVWCTLEGVGERVPVRLIEGAQRSEVLKSLGLEQRAQQEPLQFVA 203 Query: 201 VQCQQRLPNEAHVKLVWDRGIAAANAPAVVTSQPQVFNFQVRSEFAASLSCQRENANAAC 260 + C +RL + + V+LV+ +G+A + V + + F+++VR FAA SC+RENA AAC Sbjct: 204 LACNRRLTSGSRVQLVFGKGVATPSG--VPNAVEKRFDYRVRQPFAAEFSCERENAQAAC 261 Query: 261 SPILPVTLSFSAPVPRKLAEQVVMNATTGKIKPTLEG-----DKDEAVRELRFKPPFPEK 315 PI P+ LSF+APVPRKLA + + + +KP ++G D V ++F P E Sbjct: 262 LPIRPLQLSFNAPVPRKLASAIRLKSAAETLKPQVDGAAQGQPADALVGSVQFAAPLAEN 321 Query: 316 SDFTISLPSGFKDEDGRTLANAGAFPLKSALADFPPLAKFPAAPFGIIELNAD-----PT 370 + FTI LP FKD GR L NAG+FPLK A PPLAKF AAPFGI+E A+ Sbjct: 322 TAFTIELPKDFKDASGRALRNAGSFPLKVATGGMPPLAKFAAAPFGIVERFAEGPQGPAL 381 Query: 371 LPVTLRRVEAGLQVRG-KDGRAMPGQVADLKVNGDKAVIAWLTRLNKYHEKWGDPKK--- 426 LPVTLR VEA L+V+G + G A G+V+ L+ D +IAW ++ +Y D K+ Sbjct: 382 LPVTLRNVEAALRVQGLQPGAAPTGKVSTLRPTADADIIAWFRKVQRYDSYMVDRKQARA 441 Query: 427 ----------------VDTRSVSLLAKESGAKKLDLPAQKDAKDGEWPFEVIGIPLKDPG 470 V +R VSLLA + G K LDLP K A + PFEV+GIPL PG Sbjct: 442 DATGPLPRVLDSAAENVQSRMVSLLAGKGGVKTLDLP--KPAGNDPRPFEVVGIPLT-PG 498 Query: 471 FYVVELESQKLGASLL----GKPQPMYVRTSALVTNLSVHVKLGRANGAVWVTRLDDAKP 526 F+VVE+ SQKLGASLL G+ + MYVRTSALVTNL VH KLGR N WVT LD +P Sbjct: 499 FHVVEIASQKLGASLLDERHGEGRTMYVRTSALVTNLGVHFKLGRENALAWVTTLDRGQP 558 Query: 527 VADAEIRVSNCDGAQIWQGKTNASGVAMMPALEDACANRGYSPDNA-----DKINGLFVS 581 VA+A +RVS+C G Q+ TNA G+A + G SP+ A D FVS Sbjct: 559 VANASVRVSDCSGRQLATATTNAQGIATL---------EGLSPEPALCSDTDGGQAYFVS 609 Query: 582 ARKTDEKGRQDMAFALTSWNEGIESWRFNLPTDMDKSATVRATTVFDRTLFRAGETVSMK 641 AR G +DMAF + W GIESWRFN+PT + RA T+FDRTL RAGETVSMK Sbjct: 610 ARSKGADGVEDMAFTWSDWQRGIESWRFNVPTSTEAQPDERAHTIFDRTLLRAGETVSMK 669 Query: 642 HVIRTETLQGFGLMRKEDLPTRVRISHLGSGQQYQFPLTWR----GNKSAETTFVLPKQA 697 H++R+E +GFGL + P + I+H GSGQQY PL WR G SA+++F +P A Sbjct: 670 HLLRSENRKGFGL--PAERPGTLVITHTGSGQQYTQPLAWRSTATGGLSAQSSFAVPPAA 727 Query: 698 KLGSYEVVLDQGKVDANASAEPPEQSDDGDYEGGYGRGTYVTGSFRVEEFRLPLMQGRIT 757 KLG YEV L D GG G+ G FRVEEFRLP+++GRI Sbjct: 728 KLGLYEVELRS------------------DKPGGRSFGS---GQFRVEEFRLPVLEGRIA 766 Query: 758 PP-KGAQVAVKEMPLDLQLNYINGGAAANQAVQVSSLLRSRSLNIAGYDGFSFDAPRSDE 816 P K V V+ +P D+Q+NY+ GG AAN V+VS+L+R + L + YD FSF+ PR E Sbjct: 767 PSDKKPLVHVRSVPTDVQINYVAGGGAANLPVRVSALVRGKYLQFSDYDSFSFNPPRKRE 826 Query: 817 DSNAD----------DQKIVADKLAITLDKNGAGRATISKLPALQRPQELLTEMTYSDPN 866 S+A D +++ADKL +TLD+NGAG+ I +P +RPQELL E TY+DPN Sbjct: 827 QSSAHSDDEEATASQDARVIADKLPLTLDRNGAGKLGIDNVPQARRPQELLLEATYADPN 886 Query: 867 GEVQTISNVTPLWPSAVVVGLRTGNWVSVKKKLTLTAVTLNTAGQPQAGVPVEIRGTARK 926 GEVQT+ + LWP+ VV G++T WVS ++K+ A+ L G+ ++++ AR Sbjct: 887 GEVQTLRSTHTLWPAGVVAGIKTEGWVSARQKIRFQALALQHDGKAAPDTGLQVQAIARI 946 Query: 927 TNSHRKRMVGGFYAYENDETKQDLGKLCSGKSDQHGMFTCDTELSEAGNVELIASAKDGN 986 T + RKRMVGGFY+Y+N +DLG +CSGKSD G+ C+ L EAG VEL+A+A D + Sbjct: 947 TTTTRKRMVGGFYSYDNQTETKDLGTVCSGKSDSRGLLLCEARLDEAGEVELVATATDKD 1006 Query: 987 GNAAAARSSVWVTGRGEVWFDGENQDRIDILPEKKNYQPGETANFQVRMPFRSATALVAV 1046 GN + A +SVWVT +GE+WF GE+ DRID+LPEKK+YQPGE A FQVRMPFR ATALVAV Sbjct: 1007 GNTSEAAASVWVTRQGELWFGGEDHDRIDLLPEKKSYQPGEVAKFQVRMPFRFATALVAV 1066 Query: 1047 EREGVIDTRVVQLSGQDPTISVPMKAEYGPNVYVSVLAVRGRMREVPWYSFFIWGWKEPI 1106 EREG+I+T+VVQL+GQDPT+S+ ++ +GPNVYVSVLA+RGR+R+VPWYSFF WG+K P Sbjct: 1067 EREGIIETQVVQLNGQDPTVSLKVQEGWGPNVYVSVLALRGRLRDVPWYSFFTWGFKSPR 1126 Query: 1107 NWWHEF----REYQGPGPIVDLSKPAWKFGIAEVNVGDAGHRLQVAVSTDKPTYPIRAIA 1162 WW F +EYQ P +VDLSKPA++ G+AE+ VG HR+ V V+ DK +YP+R A Sbjct: 1127 EWWTSFWYEGKEYQAPTALVDLSKPAFRLGLAEIRVGTQAHRIDVKVAADKESYPVRGKA 1186 Query: 1163 KVQVQVKLPNGKPAAGGEFALAAVDEALLELQPNGSWDVLHAMLQRRSYGVETSTAQMQV 1222 +V + LP GKPAA E ALAAVD+ALLEL PN SW++L AMLQRRS+GV+TSTAQM++ Sbjct: 1187 QVTITATLPGGKPAANAEVALAAVDQALLELMPNTSWNLLDAMLQRRSWGVQTSTAQMEI 1246 Query: 1223 VGKRHYGKKATPAGGGGGRAPTRELFDTLLVWKPNVTLDAEGRAQLDVPLNDALTSFRIV 1282 +G+RHYGKKA PAGGGGGRA TREL DTLL+W+P + LDA G+A++ VPLNDALT+F+IV Sbjct: 1247 IGRRHYGKKAVPAGGGGGRAQTRELLDTLLLWEPALKLDANGQAKVTVPLNDALTTFKIV 1306 Query: 1283 AIAENGISDFGTGSISIRSTQDVQVISGLPPLVREGDSFNGAVTVRNTTTHDMTIKVAAR 1342 A+A+ FG+G+ IR+TQD+Q+ISGLPPLVRE D F +T+RNTT M ++VA R Sbjct: 1307 AVADASTGLFGSGATQIRATQDLQIISGLPPLVREDDQFRAQLTLRNTTKAAMKVEVAPR 1366 Query: 1343 AQGGTATSTLTLPEREVKIAAGQSAEVMWPVQTPEGINQ-----LAWEISAQEQGGQKAR 1397 A + L L + V I G+S EV W V P + Q + WEI A++ AR Sbjct: 1367 A------TLLDLKPQTVDIPVGESREVAWNVTAPAQLAQTRAQAILWEIEAKDT-VSGAR 1419 Query: 1398 DAMKFTQRVVPAVPVTVQQATLFQLDKNAALDVARPADSLPGRGGLAISLKPSLAGGSDA 1457 DA+K +Q+++PAVP+TVQQATL Q++ + LDV PAD+LPGRGGL +SL+P LA G Sbjct: 1420 DALKASQKLIPAVPLTVQQATLVQVEGSFNLDVNPPADALPGRGGLKMSLQPKLAEGLPG 1479 Query: 1458 LTRYFVNYPFACLEQKTSKAIGLRDEAAWQKIVADLPTYLDGDGLAYYFPPSDSGARRGS 1517 + ++ YPFACLEQKTSKA+GLRD A WQ +VA LPTYLD DGLA YFPP D A RGS Sbjct: 1480 VRDWWARYPFACLEQKTSKAVGLRDGALWQTVVAQLPTYLDSDGLANYFPPRDGDASRGS 1539 Query: 1518 DTLTAYLLAATNEA-----GYAIPQASRDKMLDGLAAFVEGKVMRDFWSPQKDLDVRKLA 1572 DTLTAY+LAAT+EA +A+P R M GL AF+EG++ R FWSP+KDLD+RKLA Sbjct: 1540 DTLTAYVLAATHEAAAINPAFALPDDVRAPMERGLIAFIEGRIERSFWSPRKDLDMRKLA 1599 Query: 1573 ALEALSRYNRVQPAMLGSLQINPNVWPTSGLLDWIAILQRVPAIPDRQKKLDEADQILRA 1632 A+EALSRY + Q M+GS+ I PN WPT ++DW+ IL+RV +P+R K+L EA QILRA Sbjct: 1600 AIEALSRYGKAQGRMVGSITIAPNQWPTHAVIDWVNILKRVADVPERDKRLAEAMQILRA 1659 Query: 1633 RLNFQGTRMGFSNEEGDYWWWLMSSGDANANRLILLELNNPAWREDMPRLIAGAIGRQQR 1692 RL+FQGT++ FS E+ DYWWWLM +GD N RL+L +++PAW++DM RL G I RQQ Sbjct: 1660 RLSFQGTKLIFSTEQDDYWWWLMQNGDVNTARLMLAVMDDPAWKDDMGRLANGFISRQQA 1719 Query: 1693 GHWSTTTANVWGSLALEKFARKFESEPVTGATRATLEQNG---------------ASAAT 1737 G W TTTAN+WG LALEKF+ +FE+ PV+G T+A + N AS A Sbjct: 1720 GAWHTTTANLWGGLALEKFSARFEATPVSGTTKAAMGGNNASVDWSKVERIKTSDASGAA 1779 Query: 1738 QSLAWSGAP------NGGKLQLPWPEGNAQGGSVRLA--QEGNGKPWVTLQSLAAVPLKQ 1789 W GAP G + LPW G A GG +LA +G GKPW+TLQS+AA+ LK Sbjct: 1780 HQTTWFGAPAAPGMLRGNGMFLPW--GKA-GGKEQLAVTHQGPGKPWLTLQSVAAIDLKA 1836 Query: 1790 PFAAGYRITRKVEAIEQKQ----AGVYTRGDVLRVTLDIDAQAEMTWVVVSDPVPGGATL 1845 PFAAGY + + + +EQ AG YTRGDVLRVTL+++A A+MTWV ++DP+PGGAT+ Sbjct: 1837 PFAAGYALRKTITPVEQANKSLPAGQYTRGDVLRVTLEVNASADMTWVAITDPIPGGATI 1896 Query: 1846 LGSGLGRDSAIA-QGKQDAPRERGMGWLAYEERSFEAYRAYYEAMPKGRTSISYTVRLNN 1904 LGSGLGRDS IA QG+ + G GW A+EERSFE++R+YYE +PKG + YTVRLNN Sbjct: 1897 LGSGLGRDSEIATQGE----KRSGSGWPAFEERSFESFRSYYEYLPKGTVKMEYTVRLNN 1952 Query: 1905 AGEFNLPPTRVEAMYAPEMFGEVPNGKLVVKA 1936 AG+F LPP+RVEA+YAPEMFGE PN ++ V A Sbjct: 1953 AGDFALPPSRVEALYAPEMFGEAPNARVKVLA 1984 >Q1LHH3.1 Q1LHH3_RALME Large extracellular alpha-helicalprotein Length = 1993 Score = 1926 bits (4990), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1013/2018 (50%), Positives = 1326/2018 (65%), Gaps = 158/2018 (7%) Query: 24 AASATVQSFSPQGEVQRIRQVRARFSESMVKFGDPKAASPFDADC---AVAGTARWADDK 80 A++A + FSP+G V ++RQV RF E+MV GD KAA P C +V G+ RW + Sbjct: 27 ASAAQITRFSPEGVVPQVRQVAIRFDEAMVPMGDLKAAPPAAVSCTGGSVGGSGRWVNAT 86 Query: 81 NWVYDFERDLPPGTRCSFTLRAEAKSVAGNSVGGKTRFQFSTGGPAVSRVQPYSGAQIAE 140 NWVYDFERDLPPG RCS + A KSVAG + GK ++F TGGP V +P SG QI E Sbjct: 87 NWVYDFERDLPPGVRCSVRMSAGLKSVAGKTYAGKPEYRFETGGPFVISARP-SGGQIEE 145 Query: 141 DQAFILFQNGPATEPSVRQHLYCEAEGINERIPAKAVGEADRKALLQQF----AKGVDPA 196 DQ F+L NG AT S+R+H +C+AEG+ ERIP + + +R +++ +P Sbjct: 146 DQVFVLRFNGAATAGSIREHAWCQAEGLGERIPVRLLTGKERDGVIEAVRWNDIVKQNPE 205 Query: 197 SVTIVQCQQRLPNEAHVKLVWDRGIAAANAPAVVTSQPQVFNFQVRSEFAASLSCQRENA 256 +V ++ CQQRLP A ++LV D GI+ + + T+ P+ F++QVR FAA +C+RE A Sbjct: 206 AVHLLACQQRLPAGARMQLVLDAGISTPSG--LATTAPRRFDYQVREPFAAGFTCERERA 263 Query: 257 NAACSPILPVTLSFSAPVPRKLAEQVVMNATTGKIKPTLEGD--KDEAVRELRFKPPFPE 314 A C+P+ P+ ++F+APVPRKLAE +V+ +G P + D +D V + F PFPE Sbjct: 264 EAPCTPLRPLVVTFTAPVPRKLAEHIVLKTPSGPRAPKFDSDDARDAPVSSVTFPGPFPE 323 Query: 315 KSDFTISLPSGFKDEDGRTLANAGAFPLKSALADFPPLAKFPAAPFGIIELNAD------ 368 K+ TI P KDE GR+L+NA FP+K A PPLAKF AAPFG++E AD Sbjct: 324 KASLTIEAPKDLKDESGRSLSNADLFPIKLTTAALPPLAKFAAAPFGVVERFADVPRGKS 383 Query: 369 -----PTLPVTLRRVEAGLQVRGKDGRAMPGQVADLKVNGDKAVIAWLTRLNKYHEK-WG 422 P LPVTLR VEA L RA G VA LKV+ D A++ W + + HE W Sbjct: 384 PADYPPLLPVTLRNVEADLP--ALSARAEAGTVARLKVDDDGAILRWFGMVKRMHENSWT 441 Query: 423 --------------------DPKKVDTRSVSLLAKESGAKKLDLPAQKDAKDGEWPFEVI 462 + ++TRSVSLL SGAK L +P D PFEV+ Sbjct: 442 RQELDAIRAGKSPSEARSPRNAPSIETRSVSLLEGVSGAKTLAIPKSNDTSPR--PFEVV 499 Query: 463 GIPLKDPGFYVVELESQKLGASLLGKPQPMYVRTSALVTNLSVHVKLGRA------NGAV 516 GIPL +PGF+VVE+ S LG +LLG+ PMYVRT+ LVTNL VH KL R +G Sbjct: 500 GIPLPEPGFHVVEIASPMLGEALLGRKAPMYVRTAVLVTNLGVHFKLARGLADGDMSGLA 559 Query: 517 WVTRLDDAKPVADAEIRVSNCDGAQIWQGKTNASGVAMMPALEDACANRGYSPDNADKIN 576 WVT LDD KPVA+A++ V +CDG + +G T+A+GV L D R Y D A+ ++ Sbjct: 560 WVTSLDDGKPVANAKVAVRSCDGELLGEGATDATGVVRFAKLPD----RRYK-DCANGMD 614 Query: 577 GLFVSARKTDE----KGRQDMAFALTSWNEGIESWRFNLPTDMDKSATVRATTVFDRTLF 632 G FVSAR + +G+ DMAF ++ WN GIE+WRFN+PTD+ + TVRA T+FDRTL Sbjct: 615 GYFVSARIAADHPQARGKADMAFVMSDWNRGIETWRFNVPTDLSPNQTVRAHTIFDRTLL 674 Query: 633 RAGETVSMKHVIRTETLQGFGLMRKEDLPTRVRISHLGSGQQYQFPLTWR----GNKSAE 688 R GETVSMKH+IRTET QGF L +P ++ I+H GSGQ Y+ PL WR G +SAE Sbjct: 675 RVGETVSMKHLIRTETAQGFAL--PAAMPDKMVITHEGSGQTYELPLAWRNTATGGRSAE 732 Query: 689 TTFVLPKQAKLGSYEVVLDQGKVDANASAEPPEQSDDGDYEGGYGRG-TYVTGSFRVEEF 747 F +P+ AKLG Y+V L YG G T +GSFRVE F Sbjct: 733 NAFQVPQAAKLGVYDVALV------------------------YGDGRTLSSGSFRVEAF 768 Query: 748 RLPLMQGRITPPK------GAQVAVKEMPLDLQLNYINGGAAANQAVQVSSLLRSRSLNI 801 RLP++ G ++ K A VA E+P+ ++++Y NGG AA V VS+L+R++ +N Sbjct: 769 RLPVLAGTLSVTKDPKAKGNALVAPAEVPVGVEIHYTNGGGAAGLPVSVSALMRNKYVNF 828 Query: 802 AGYDGFSFDAPRSDEDSNA---------------DDQKIVADKLAITLDKNGAGRATISK 846 A YD FSF+APR + +A + +K+VADKL +TLDK+G G+ TI K Sbjct: 829 ADYDDFSFNAPRPQQQQSASGDEEEDQEGESSRDEAEKLVADKLPLTLDKDGNGKVTIKK 888 Query: 847 LPALQRPQELLTEMTYSDPNGEVQTISNVTPLWPSAVVVGLRTGNWVSVKKKLTLTAVTL 906 LP + P +L+ E ++DPNGE+QT+ PLWPSAVV G+R NWVSV +KL + V L Sbjct: 889 LPKVNVPGDLVLEAGFADPNGEIQTLRQTVPLWPSAVVAGIRAANWVSVSQKLAVYGVVL 948 Query: 907 NTAGQPQAGVPVEIRGTARKTNSHRKRMVGGFYAYENDETKQDLGKLCSGKSDQHGMFTC 966 +T G+P A PV+++ +AR T S RKR+VGGFY Y+N +DLG +C ++D G C Sbjct: 949 DTQGKPIADTPVQVKASARITTSARKRVVGGFYRYDNRSETKDLGVVCETRTDAQGRARC 1008 Query: 967 DTELSEAGNVELIASAKDGNGNAAAARSSVWVTGRGEVWFDGENQDRIDILPEKKNYQPG 1026 + LS+AG VEL+A+A+DG+G A ++VWVT +GE+WF GEN DR+D+LPEKK Y PG Sbjct: 1009 EVALSQAGEVELVANARDGDGRVTQAATTVWVTRQGELWFGGENHDRMDVLPEKKAYAPG 1068 Query: 1027 ETANFQVRMPFRSATALVAVEREGVIDTRVVQLSGQDPTISVPMKAEYGPNVYVSVLAVR 1086 +TA FQVRMPFR ATALVA+EREG++DT VV+L+G DPTI + +K E+GPNVYVSVL++R Sbjct: 1069 DTAVFQVRMPFRRATALVAIEREGILDTEVVELNGTDPTIKLKVKPEWGPNVYVSVLSIR 1128 Query: 1087 GRMREVPWYSFFIWGWKEPINWWHEFR----EYQGPGPIVDLSKPAWKFGIAEVNVGDAG 1142 GR+REVPWYSFF WGW++P++WWH FR EY P P+VDLSKPA++ G+AE+ VG+ Sbjct: 1129 GRLREVPWYSFFTWGWRQPLDWWHAFRSEGKEYVAPSPLVDLSKPAFRLGLAEIRVGNEA 1188 Query: 1143 HRLQVAVSTDKPTYPIRAIAKVQVQVKLPNGKPAAGGEFALAAVDEALLELQPNGSWDVL 1202 HRL V V+ DK TYP+R A V VQVKLP+GKPAA GE ALAAVD++LLEL PN SW++L Sbjct: 1189 HRLDVTVTPDKATYPVRGKAHVVVQVKLPDGKPAANGEVALAAVDQSLLELMPNTSWNLL 1248 Query: 1203 HAMLQRRSYGVETSTAQMQVVGKRHYGKKATPAGGGGGRAPTRELFDTLLVWKPNVTLDA 1262 AMLQRRSYGVETSTAQM+++G+RHYG+KA AGGGGG++PTRELFDTLL+W P V LDA Sbjct: 1249 DAMLQRRSYGVETSTAQMEIIGRRHYGRKAVAAGGGGGKSPTRELFDTLLLWNPRVQLDA 1308 Query: 1263 EGRAQLDVPLNDALTSFRIVAIAENGISDFGTGSISIRSTQDVQVISGLPPLVREGDSFN 1322 EG+A LDVPLND+LTSFRIVA+A+ G FG+GS SI +TQD+Q+I+GLP LVRE D + Sbjct: 1309 EGKAALDVPLNDSLTSFRIVAVADLGAGRFGSGSASIAATQDLQMIAGLPLLVREDDKYR 1368 Query: 1323 GAVTVRNTTTHDMTIKVAARAQGGTATSTLTLPEREVKIAAGQSAEVMWPVQTPEGI--- 1379 T+RNTT MT++ ARA T TLP + V+I AG++ E+ W + P + Sbjct: 1369 AMFTLRNTTQRAMTVEATARA---TLVDAQTLPAQTVQIPAGEAREIGWDITAPALLAFS 1425 Query: 1380 --NQLAWEISAQEQGGQKARDAMKFTQRVVPAVPVTVQQATLFQLDKNAALDVARPADSL 1437 + WE+ A E+G A D +K +Q++VPA+PVTVQQA L QL NA++ V PA +L Sbjct: 1426 RGGSILWEVGATEKGTGTASDKLKVSQQIVPAIPVTVQQAVLAQLTPNASMPVQAPAGAL 1485 Query: 1438 PG-----RGGLAISLKPSLAGGSDALTRYFVNYPFACLEQKTSKAIGLRDEAAWQKIVAD 1492 RGG+ +SL+ SLAGG + +F NYPF CLEQ++SKA+GL D AAW ++ Sbjct: 1486 ADPKGQVRGGMQVSLQSSLAGGMPGVREWFRNYPFTCLEQRSSKALGLGDAAAWDALMVQ 1545 Query: 1493 LPTYLDGDGLAYYFPPSDSGARRGSDTLTAYLLAATNEAGYA-----IPQASRDKMLDGL 1547 LP+YLD +GLA YFP G+ GS+ LTAYLL+ ++EA A +P A RD+M GL Sbjct: 1546 LPSYLDSNGLAAYFPLRSDGS-YGSEVLTAYLLSISDEAARAGLPMRVPDALRDQMERGL 1604 Query: 1548 AAFVEGKVMRDFWSPQK---DLDVRKLAALEALSRYNRVQPAMLGSLQINPNVWPTSGLL 1604 AFVEG++ W+P DLDVRKLAAL+ALSR Q MLGS+QI P WPTS L+ Sbjct: 1605 TAFVEGRITPPRWAPSSATMDLDVRKLAALDALSRTGHAQARMLGSIQILPEQWPTSALI 1664 Query: 1605 DWIAILQRVPAIPDRQKKLDEADQILRARLNFQGTRMGFSNEEGDYWWWLMSSGDANANR 1664 DW+ IL RV IP R K++ EA Q+LR+RL QGTR+ FS E D WWWLMS GD NA + Sbjct: 1665 DWLGILSRVQDIPQRDKRMAEATQLLRSRLTVQGTRLVFSTERTDNWWWLMSGGDVNAAK 1724 Query: 1665 LILLELNNPAWREDMPRLIAGAIGRQQRGHWSTTTANVWGSLALEKFARKFESEPVTGAT 1724 L+ L P W+ D+P L+ G +GRQ RG W TTTAN WG LA++++A+ +E PV GA Sbjct: 1725 LLALATQLPDWKGDVPELVTGLLGRQTRGAWMTTTANAWGVLAIQRYAQVYEKTPVAGAA 1784 Query: 1725 RATLEQNGASAATQSLAWSGAPN-----GGKLQLPWPEGNAQG-GSVRLAQEGNGKPWVT 1778 R L A+++ WS A G ++LPWP + ++++ Q+G+G+PW T Sbjct: 1785 RVALGD-----ASRTFEWSKATQKDGVASGMVELPWPAKTSTAPATLQVEQQGSGRPWAT 1839 Query: 1779 LQSLAAVPLKQPFAAGYRITRKVEAIEQKQAGVYTRGDVLRVTLDIDAQAEMTWVVVSDP 1838 +++LAAVP +P +AGYR+ R V ++Q AG ++RGD RV LDIDAQA+MTWVVVSDP Sbjct: 1840 VRALAAVPPTEPVSAGYRVRRTVTPVDQAVAGKWSRGDTYRVKLDIDAQADMTWVVVSDP 1899 Query: 1839 VPGGATLLGSGLGRDSAIAQGKQDAPRERGMGWLAYEERSFEAYRAYYEAMPKGRTSISY 1898 VP GAT+LGSGLGRDS IA R+ W A+ ER+ YR Y+ +PKG S+ Y Sbjct: 1900 VPTGATILGSGLGRDSEIAT------RDEKKSWSAFTERTPAVYREYFGYVPKGALSVEY 1953 Query: 1899 TVRLNNAGEFNLPPTRVEAMYAPEMFGEVPNGKLVVKA 1936 TVRLNNAGEF LPPTRVEA+YAP++FGE PN K+ V A Sbjct: 1954 TVRLNNAGEFTLPPTRVEALYAPDVFGETPNAKMTVGA 1991 >Q46VU1.1 Q46VU1_CUPPJ Alpha-2-macroglobulin, N-terminal Length = 2016 Score = 1926 bits (4989), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1038/2037 (50%), Positives = 1333/2037 (65%), Gaps = 142/2037 (6%) Query: 3 AAALAFALGATMSLLPVKPAQAASATVQSFSPQGEVQRIRQVRARFSESMVKFGDPKAAS 62 A A A+ ++ L V A AA T FSP+G V ++RQV RF E+MV GD +AA+ Sbjct: 17 ARASRVAMAGVLAWLSVSAAFAAQVT--RFSPEGTVPQVRQVAIRFDEAMVPMGDVQAAA 74 Query: 63 PFDADC---AVAGTARWADDKNWVYDFERDLPPGTRCSFTLRAEAKSVAGNSVGGKTRFQ 119 P C A AG RW D NWV+DFERDLPPG RCS + A +S AG + GK ++ Sbjct: 75 PAAIACTGAATAGHGRWVDASNWVFDFERDLPPGVRCSVRMSASLRSAAGKAYAGKPEYR 134 Query: 120 FSTGGPAVSRVQPYSGAQIAEDQAFILFQNGPATEPSVRQHLYCEAEGINERIPAKAVGE 179 F TGGP V +P SG +I EDQ F L NG AT SVR H +C+AEG+ ERIP + + Sbjct: 135 FETGGPTVVASRP-SGGEIEEDQIFALRFNGAATAASVRDHAWCQAEGLGERIPVRLLTG 193 Query: 180 ADRKALL-----QQFAKGVDPASVTIVQCQQRLPNEAHVKLVWDRGIAAANAPAVVTSQP 234 +R +L ++ AK P ++ ++ CQQRLP A ++LV GIA + + T Sbjct: 194 KERDGVLDAIYWKRIAKDA-PDAIHLLACQQRLPAGARMQLVLGAGIATPSG--LATRDE 250 Query: 235 QVFNFQVRSEFAASLSCQRENANAACSPILPVTLSFSAPVPRKLAEQVVMNATTGKIKPT 294 + F++ VR F AS SC+RE+A + C+P+ P+T+SFSAP+ R+LAE VV+ +G P Sbjct: 251 RRFDYTVREPFTASFSCEREHAQSPCTPLRPMTVSFSAPISRRLAEHVVLKTPSGPRAPQ 310 Query: 295 LEGD--KDEAVRELRFKPPFPEKSDFTISLPSGFKDEDGRTLANAGAFPLKSALADFPPL 352 E D D V L F PF EK++FTI +P KD+ GRTLANA FPLK + A PPL Sbjct: 311 FEVDLAPDANVTSLTFAAPFAEKANFTIEIPRDLKDDSGRTLANADLFPLKVSTASMPPL 370 Query: 353 AKFPAAPFGIIELNAD-----------PTLPVTLRRVEAGLQVRGKDGRAMPGQVADLKV 401 AKF AAPFG++E + P LPVTLR VEA LQVRG +A G V LKV Sbjct: 371 AKFAAAPFGVVERFGELPKGKAPADYPPLLPVTLRNVEADLQVRGVQAQA--GTVMKLKV 428 Query: 402 NGDKAVIAWLTRLNKYHE-KW-----------------GDPKK---VDTRSVSLLAKESG 440 + D AV+ WL + + HE W +P+ ++TRSVSLL + G Sbjct: 429 DDDGAVLRWLGLVRRMHEASWTRAELDAVLAGRSPYGVNNPRNAPSIETRSVSLLERAQG 488 Query: 441 AKKLDLPAQKDAKDGEWPFEVIGIPLKDPGFYVVELESQKLGASLLGKPQPMYVRTSALV 500 +KL +P K + D PFEV+GIPL +PGF+VVE+ S LG +LLGK PMYVRT+ALV Sbjct: 489 VQKLSVP--KPSGDAPRPFEVVGIPLPEPGFHVVEIASPMLGEALLGKRAPMYVRTAALV 546 Query: 501 TNLSVHVKLGRANG------AVWVTRLDDAKPVADAEIRVSNCDGAQIWQGKTNASGVAM 554 TNL VH KL R +G WVT LDD KPV DA + V +C G + +G+T+ASGV Sbjct: 547 TNLGVHFKLARGDGDGSMSGLAWVTALDDGKPVRDAAVAVRDCSGRLLGEGRTDASGVVR 606 Query: 555 MPALEDACANRGYSPDNADKINGLFVSAR----KTDEKGRQDMAFALTSWNEGIESWRFN 610 L+D RG + D + + G FVSAR + +G+ DMAF ++ WN GIE+WRFN Sbjct: 607 FAKLDDV---RGRTCDG-NGLMGYFVSARIAATHPEARGKADMAFVMSDWNRGIETWRFN 662 Query: 611 LPTDMDKSATVRATTVFDRTLFRAGETVSMKHVIRTETLQGFGLM-RKEDLPTRVRISHL 669 +PTD + TVRA TVFDRTL R GETVSMKH IR+ET QGF L LP V I H Sbjct: 663 VPTDASATQTVRAHTVFDRTLLRVGETVSMKHFIRSETAQGFALPPENRKLPETVVIRHE 722 Query: 670 GSGQQYQFPLTWR----GNKSAETTFVLPKQAKLGSYEVVLDQGKVDANASAEPPEQSDD 725 GSGQ Y+ PL WR G +SAE++F +P AKLG Y V L E S D Sbjct: 723 GSGQTYELPLQWRNTATGGRSAESSFQVPPAAKLGVYNVALQA------------EGSGD 770 Query: 726 GDYEGGYGRGTYVTGSFRVEEFRLPLMQGRITPPKG---AQVAVKEMPLDLQLNYINGGA 782 G TY +GSFRVE FRLP++ G + G A VA E+P+ ++++Y++GG Sbjct: 771 GSDSSAR---TYSSGSFRVEAFRLPVLTGTLQASGGKGGAVVAPAELPVGVEVHYVSGGG 827 Query: 783 AANQAVQVSSLLRSRSLNIAGYDGFSFDAPR--------SDEDSNADD-------QKIVA 827 AA V+VS+LLR + +N GYD +SF PR +E S+ D+ QK++A Sbjct: 828 AAGLPVRVSALLRDKWINFPGYDEYSFSPPRPTRENASGDEEMSDVDEGQARDGAQKLIA 887 Query: 828 DKLAITLDKNGAGRATISKLPALQRPQELLTEMTYSDPNGEVQTISNVTPLWPSAVVVGL 887 DKL +TLDKNG G T+ K+P + P++L+ E ++DPNGEVQT+ P+WPSAVV G+ Sbjct: 888 DKLPLTLDKNGNGSVTLRKMPKIDAPRDLVLEAGFADPNGEVQTLRQTVPVWPSAVVAGI 947 Query: 888 RTGNWVSVKKKLTLTAVTLNTAGQPQAGVPVEIRGTARKTNSHRKRMVGGFYAYENDETK 947 RT WVSVK+KL + + L+T G+P A PV+ AR T S RKR+VGGFY Y+N Sbjct: 948 RTEGWVSVKQKLAVHGLVLDTQGKPVADAPVKFNARARITTSTRKRVVGGFYRYDNRSES 1007 Query: 948 QDLGKLCSGKSDQHGMFTCDTELSEAGNVELIASAKDGNGNAAAARSSVWVTGRGEVWFD 1007 +DLG +C ++D G CD L +AG VEL+A A+D +G +A A S+VWVT +GE+WF Sbjct: 1008 RDLGTVCETRTDVQGRARCDVTLDQAGQVELVAIARDKDGRSAQAASTVWVTRQGELWFG 1067 Query: 1008 GENQDRIDILPEKKNYQPGETANFQVRMPFRSATALVAVEREGVIDTRVVQLSGQDPTIS 1067 GEN DRID+LPEKK Y PG+TA FQVRMPFR ATALVAVEREGV++T+VV+L+G DPT+ Sbjct: 1068 GENHDRIDVLPEKKQYAPGDTAVFQVRMPFRQATALVAVEREGVLETQVVELNGSDPTVR 1127 Query: 1068 VPMKAEYGPNVYVSVLAVRGRMREVPWYSFFIWGWKEPINWWHEFR----EYQGPGPIVD 1123 V +K E+GPNVYVSV+ +RGR+ EVPWYSFF WGW++P WW FR EY P +VD Sbjct: 1128 VKVKPEWGPNVYVSVMTIRGRLHEVPWYSFFTWGWRQPGEWWRAFRSEGKEYAAPTALVD 1187 Query: 1124 LSKPAWKFGIAEVNVGDAGHRLQVAVSTDKPTYPIRAIAKVQVQVKLPNGKPAAGGEFAL 1183 LS+PA++ G+AE+ VG+ HRL V V+ DK +Y +R A+V +QVKLP+GKPAA GE AL Sbjct: 1188 LSRPAFRLGLAEIRVGNEAHRLDVTVTPDKASYSVRGKARVALQVKLPDGKPAANGEIAL 1247 Query: 1184 AAVDEALLELQPNGSWDVLHAMLQRRSYGVETSTAQMQVVGKRHYGKKATPAGGGGGRAP 1243 AAVD+ALLEL PN SWD+L AMLQRRSYGVETSTAQM+++G+RHYG+KA PAGGGGG++P Sbjct: 1248 AAVDQALLELMPNNSWDLLDAMLQRRSYGVETSTAQMEIIGRRHYGRKAVPAGGGGGKSP 1307 Query: 1244 TRELFDTLLVWKPNVTLDAEGRAQLDVPLNDALTSFRIVAIAENGISDFGTGSISIRSTQ 1303 TRELFDTLL+W P V LDAEGRA +DVPLND+LTSFRIVA+A+ G+ FGTGS +I +TQ Sbjct: 1308 TRELFDTLLLWNPRVQLDAEGRATVDVPLNDSLTSFRIVAVADLGVGRFGTGSATIAATQ 1367 Query: 1304 DVQVISGLPPLVREGDSFNGAVTVRNTTTHDMTIKVAARAQ-GGTATSTLTLPEREVKIA 1362 D+QVISGLP L+RE D + T+RNTT MT++ +ARA G A + LP + V+I Sbjct: 1368 DLQVISGLPMLIREDDRYRAMFTLRNTTKRAMTVQASARATLVGNANA---LPVQTVQIP 1424 Query: 1363 AGQSAEVMWPVQTPEGI-----NQLAWEISAQEQGGQKARDAMKFTQRVVPAVPVTVQQA 1417 AG++ E+ W V P + + WE+ A EQG A D +K +Q++VPA PVTVQQA Sbjct: 1425 AGEAREIGWDVTAPALLAFSRSGTVQWEVQAAEQGSGGATDRIKVSQQIVPAEPVTVQQA 1484 Query: 1418 TLFQLDKNAALDVARPADSLPG-----RGGLAISLKPSLAGGSDALTRYFVNYPFACLEQ 1472 TL QL ++ V P +L RGGL ++L+ SLAGG + +FVNYPF+CLEQ Sbjct: 1485 TLAQLTPQLSVPVKAPPGALADPTGKVRGGLQVNLQSSLAGGMPGVREWFVNYPFSCLEQ 1544 Query: 1473 KTSKAIGLRDEAAWQKIVADLPTYLDGDGLAYYFPPSDSGARRGSDTLTAYLLAATNEAG 1532 +TSKAIGL D AW+ ++ LP+YLD +GLA YF P S ++ GS LTAYLL+ ++EA Sbjct: 1545 RTSKAIGLADGTAWEALMNQLPSYLDANGLAAYF-PLRSDSQSGSVALTAYLLSISDEAA 1603 Query: 1533 YA-----IPQASRDKMLDGLAAFVEGKVMRDFWSPQK---DLDVRKLAALEALSRYNRVQ 1584 A +P R +M GL AFVEG++ D W+P DL+VRKLAALEALSR Q Sbjct: 1604 RAGLTLRVPDELRTQMERGLVAFVEGRIRPDAWAPSSATMDLEVRKLAALEALSRTGHAQ 1663 Query: 1585 PAMLGSLQINPNVWPTSGLLDWIAILQRVPAIPDRQKKLDEADQILRARLNFQGTRMGFS 1644 MLGS+QI P WPTS L+DW +L R+ IP R+ +L EA Q+LRARL QGTR+ FS Sbjct: 1664 ARMLGSIQILPAQWPTSALIDWTLLLTRMQDIPQREARLAEAQQLLRARLMVQGTRLAFS 1723 Query: 1645 NEEGDYWWWLMSSGDANANRLILLELNNPAWREDMPRLIAGAIGRQQRGHWSTTTANVWG 1704 E D WWWLMS GD NA RL+ L P W++D P+L G IGRQ RG W TT AN WG Sbjct: 1724 TERSDDWWWLMSGGDVNAARLLALAAELPGWKDDAPQLAVGLIGRQVRGAWGTTNANAWG 1783 Query: 1705 SLALEKFARKFESEPVTGATRATLEQNGASAATQSLAWSGAPN-----GGKLQLPWPEGN 1759 LA+ +FA+ FE PV G TR ++ +G SA +S+ WS A G + LPWP G Sbjct: 1784 MLAITRFAQVFEKTPVAGTTRMSVSGSGESA--RSVDWSRAQRRDGVAQGSVDLPWPGGE 1841 Query: 1760 AQGGSVRLAQEGNGKPWVTLQSLAAVPLKQPFAAGYRITRKVEAIEQKQAGVYTRGDVLR 1819 + GG+++L G G PW T++++AAVPL P AAGYR+ R V +EQ +G ++RGD R Sbjct: 1842 S-GGTLQLEHAGAGHPWATVRAMAAVPLSGPLAAGYRVRRTVTPVEQAVSGKWSRGDTYR 1900 Query: 1820 VTLDIDAQAEMTWVVVSDPVPGGATLLGSGLGRDSAIAQGKQDAPRERGMGWLAYEERSF 1879 V L++DAQA+MTWVV+SDP+P GAT+LGSGLGRDS IA + R +GM W AY ER+ Sbjct: 1901 VKLEVDAQADMTWVVISDPIPAGATILGSGLGRDSEIATRGE---RRKGMAWAAYTERTP 1957 Query: 1880 EAYRAYYEAMPKGRTSISYTVRLNNAGEFNLPPTRVEAMYAPEMFGEVPNGKLVVKA 1936 +AYR YYE +PKG S+ YTVRLNNAG+F LPPTRVEAMYAP++FG PN +L V A Sbjct: 1958 QAYREYYEYLPKGSISVEYTVRLNNAGDFALPPTRVEAMYAPDVFGAAPNARLTVGA 2014 >A1TNJ9.1 A1TNJ9_ACIAC Alpha-2-macroglobulin domain protein Length = 2007 Score = 1925 bits (4986), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1031/2023 (50%), Positives = 1333/2023 (65%), Gaps = 155/2023 (7%) Query: 28 TVQSFSPQGEVQRIRQVRARFSESMVKFGDPKAASPFDADC---AVAGTARWADDKNWVY 84 +V SFSPQGEV R+RQV +F + V FGDPKA +PF DC A GT RW ++ WVY Sbjct: 28 SVSSFSPQGEVARVRQVVVKFDAAAVNFGDPKAPAPFSVDCGGDASRGTGRWTGEREWVY 87 Query: 85 DFERDLPPGTRCSFTLRAEAKSVAGNSVGGKTRFQFSTGGPAVSRVQPYSGAQIAEDQAF 144 DF DLPPGTRC+ T R KS G ++ G R+QF+TGGP V V+P + I E+Q F Sbjct: 88 DFAADLPPGTRCTATARPGFKSANGAALSGTVRYQFNTGGPFVQSVRPGTYQPIDEEQFF 147 Query: 145 ILFQNGPATEPSVRQHLYCEAEGINERIPAKAVGEADRKALLQQF----AKGVDPASVTI 200 +L +GPAT SV+ +++C AEG+ ERIP + + A+R ALL A P Sbjct: 148 LLQLSGPATLESVKANVWCVAEGVGERIPVRLIEGAERAALLASLRLESAARQAPLRYAS 207 Query: 201 VQCQQRLPNEAHVKLVWDRGIAAANAPAVVTSQPQVFNFQVRSEFAASLSCQRENANAAC 260 + C +RL + + V+LV+ +G+A + V + + + + VR F+A C+RENA AAC Sbjct: 208 LACNRRLTSGSKVQLVYGQGVATPSG--VPNTVERRYGYTVREPFSADFGCERENAQAAC 265 Query: 261 SPILPVTLSFSAPVPRKLAEQVVMNATTGKIKPTL--EGDKDEAVRELRFKPPFPEKSDF 318 PI P+ LSF+APVPR+LAE + + + +KP L EGD D V ++F PPF ++ Sbjct: 266 LPIRPMRLSFNAPVPRRLAEAIRLKSDKETLKPLLDGEGDGDTVVNGVQFMPPFAPQTPM 325 Query: 319 TISLPSGFKDEDGRTLANAGAFPLKSALADFPPLAKFPAAPFGIIELNAD-----PTLPV 373 + LP FKD GR L NA +FPL A PPLAKF A+PFG++E A+ LPV Sbjct: 326 RLELPKDFKDASGRPLRNADSFPLAVATGPMPPLAKFAASPFGVVERFAEGDKGPALLPV 385 Query: 374 TLRRVEAGLQVRG------------KDGRAMPGQVADLKVNGDKAVIAWLTRLNKYHEKW 421 TLR VEA L+V+G A G+V+ + D +IAW R+ +Y + Sbjct: 386 TLRNVEADLRVQGLAAGAAPGASAPAAAPAPAGKVSTFQPTADADIIAWYRRVRRYDDYL 445 Query: 422 GDPKK--------------------VDTRSVSLLAKESGAKKLDLPAQKDAKDGEWPFEV 461 ++ V +R VSLL + AK LDLP + A PFEV Sbjct: 446 VTRREAGRDVRGPLPPVLENEGKDTVQSRMVSLLGGQPRAKVLDLP--RPASGDPRPFEV 503 Query: 462 IGIPLKDPGFYVVELESQKLGASLL----GKPQPMYVRTSALVTNLSVHVKLGRANGAVW 517 +GIPL PGF+VVE+ S LG SLL G + MYVRTSALVTNL VH KLGR N A W Sbjct: 504 VGIPLP-PGFHVVEIASPMLGRSLLDERHGAARTMYVRTSALVTNLGVHFKLGRENAAAW 562 Query: 518 VTRLDDAKPVADAEIRVSNCDGAQIWQGKTNASGVAMMPALED---ACANRGYSPDNADK 574 VT LD + V A +RVS CDG ++ T+A G+A L +C R D + Sbjct: 563 VTTLDKGQVVPGAVVRVSGCDGRELATATTDAQGIARFEGLSPQPPSCPGR----DGLEG 618 Query: 575 INGLFVSARKTDEKGRQDMAFALTSWNEGIESWRFNLPTDMDKSATVRATTVFDRTLFRA 634 +N FVSAR G QDMAF + W GIE WRFN+PT A T+FDRTL RA Sbjct: 619 MNAYFVSARAQGADGMQDMAFTWSDWQRGIEPWRFNVPTSSQPEPDQIAHTIFDRTLLRA 678 Query: 635 GETVSMKHVIRTETLQGFGLMRKEDLPTRVRISHLGSGQQYQFPLTWR----GNKSAETT 690 GETVSMKH++RT+ QGFGL + P + I+H+GSGQQ+ PL WR G AE+T Sbjct: 679 GETVSMKHILRTQNRQGFGLPDAQ--PHTLAITHVGSGQQFTQPLQWRRTPTGGLGAEST 736 Query: 691 FVLPKQAKLGSYEVVLDQGKVDANASAEPPEQSDDGDYEGGYGRGTYVTGSFRVEEFRLP 750 F LP AKLG+Y V E D D G ++ +G FRVEEFRLP Sbjct: 737 FALPPAAKLGAYSV----------------ELRGDDDSRGR----SFTSGEFRVEEFRLP 776 Query: 751 LMQGRITPP-KGAQVAVKEMPLDLQLNYINGGAAANQAVQVSSLLRSRSLNIAGYDGFSF 809 +++GRI P K V + +P D+Q+NY++GG AAN V+VS+L+R + L +D FSF Sbjct: 777 VLEGRIAPADKKPLVRPRSVPTDVQVNYVSGGGAANLPVRVSALVRGKPLQFPDFDAFSF 836 Query: 810 DAPR-------------SDEDSNADDQKIVADKLAITLDKNGAGRATISKLPALQRPQEL 856 + PR +E ++ADD +++ADKLA+TLD+NGAG+ I +P+ +R Q+L Sbjct: 837 EPPRRKGAQPQGGNSGDDEEPASADDARVIADKLAVTLDRNGAGKVAIDNIPSSRRAQDL 896 Query: 857 LTEMTYSDPNGEVQTISNVTPLWPSAVVVGLRTGNWVSVKKKLTLTAVTLNTAGQPQAGV 916 + E TYSDPNGEVQT+ + +WP+AVV G++T WVS +K+ A+ L G+ Q GV Sbjct: 897 VLEATYSDPNGEVQTLRSTQTVWPAAVVAGIKTEGWVSAAQKIRFQALALGLDGKVQEGV 956 Query: 917 PVEIRGTARKTNSHRKRMVGGFYAYENDETKQDLGKLCSGKSDQHGMFTCDTELSEAGNV 976 P++++ AR T + RKRMVGGFY+Y+N +DLG +C+GKSD G+ C+ L EAG V Sbjct: 957 PLQVQAVARITTTSRKRMVGGFYSYDNKTETKDLGTVCTGKSDSRGLVLCEARLDEAGEV 1016 Query: 977 ELIASAKDGNGNAAAARSSVWVTGRGEVWFDGENQDRIDILPEKKNYQPGETANFQVRMP 1036 EL+A+A+D +GN + A +SVWVT +GE+WF GE+ DRID+LPEKK+YQPGETA QVRMP Sbjct: 1017 ELVATARDKDGNQSEAAASVWVTRQGELWFGGEDHDRIDLLPEKKSYQPGETARLQVRMP 1076 Query: 1037 FRSATALVAVEREGVIDTRVVQLSGQDPTISVPMKAEYGPNVYVSVLAVRGRMREVPWYS 1096 FR ATALV+VEREG+ID RVVQL+GQDPT+ + ++ +GPNVYVSVLA+RGR+REVPWYS Sbjct: 1077 FRQATALVSVEREGIIDMRVVQLNGQDPTVQLKIEEGWGPNVYVSVLALRGRLREVPWYS 1136 Query: 1097 FFIWGWKEPINW----WHEFREYQGPGPIVDLSKPAWKFGIAEVNVGDAGHRLQVAVSTD 1152 FF WG+K P W W+E +EY P +VDLSKPA++ G+AE+ VG HR++V V+ D Sbjct: 1137 FFTWGFKAPREWWTAFWYEGKEYVAPTAMVDLSKPAYRLGLAELKVGAKVHRIEVKVTAD 1196 Query: 1153 KPTYPIRAIAKVQVQVKLPNGKPAAGGEFALAAVDEALLELQPNGSWDVLHAMLQRRSYG 1212 K +YP+R A+V + LP+GKPAA E A+AAVD+ALLEL PN SW++L AMLQRR++G Sbjct: 1197 KESYPVRGKAQVTIAATLPDGKPAANAEVAVAAVDQALLELMPNTSWNLLDAMLQRRAWG 1256 Query: 1213 VETSTAQMQVVGKRHYGKKATPAGGGGGRAPTRELFDTLLVWKPNVTLDAEGRAQLDVPL 1272 VETSTAQM+++G+RHYG+KA PAGGGGGRA TREL DTLL+W+P V LDA GRAQ+ VPL Sbjct: 1257 VETSTAQMEIIGRRHYGRKAVPAGGGGGRAQTRELLDTLLLWQPAVRLDANGRAQVTVPL 1316 Query: 1273 NDALTSFRIVAIAENGISDFGTGSISIRSTQDVQVISGLPPLVREGDSFNGAVTVRNTTT 1332 NDALT+FRIVA+A+ G FGTGS SIR+TQD+Q+ISGLPPLVRE D F T+RNTT Sbjct: 1317 NDALTTFRIVAVADAGTGRFGTGSTSIRATQDLQIISGLPPLVREDDQFRAQFTLRNTTK 1376 Query: 1333 HDMTIKVAARAQGGTATSTLTLPEREVKIAAGQSAEVMWPVQTPEGINQ-----LAWEIS 1387 M ++VA RA + LTL ++ V I AG+S EV W V P + + + WEI Sbjct: 1377 AAMKVEVAPRA------TLLTLDKQTVDIPAGESREVAWNVTAPAQLARTRAEAILWEIE 1430 Query: 1388 AQEQ--GGQKARDAMKFTQRVVPAVPVTVQQATLFQLDKNAALDVARPADSLPGRGGLAI 1445 A++ G ARDA+K TQR+VPAVP+TVQQATL Q+D + +DV PAD++PGRGGL + Sbjct: 1431 ARDTTPGAGGARDALKATQRLVPAVPLTVQQATLVQVDGSFGIDVKPPADAIPGRGGLKM 1490 Query: 1446 SLKPSLAGGSDALTRYFVNYPFACLEQKTSKAIGLRDEAAWQKIVADLPTYLDGDGLAYY 1505 S++P LA G + +F NYPF CLEQKTSKA+GLRD WQ +V LPTYLDGDGLA Y Sbjct: 1491 SVQPKLAEGLPGVRDWFANYPFLCLEQKTSKAVGLRDGKLWQAVVGQLPTYLDGDGLASY 1550 Query: 1506 FPPSDSGARRGSDTLTAYLLAATNEA-----GYAIPQASRDKMLDGLAAFVEGKVMRDFW 1560 FPP RGSDTLTAYLLAAT+EA +A+ R M GL AFVEG++ RDFW Sbjct: 1551 FPPQAGSGNRGSDTLTAYLLAATHEASSLDPAFALSPEVRASMERGLIAFVEGRIQRDFW 1610 Query: 1561 SPQKDLDVRKLAALEALSRYNRVQPAMLGSLQINPNVWPTSGLLDWIAILQRVPAIPDRQ 1620 SP+KDLD+RKLAA+EALSRY + ML S+ + PN WPT ++DW+ +L+RVP P R+ Sbjct: 1611 SPRKDLDMRKLAAIEALSRYGKATGRMLSSITVAPNQWPTHSVIDWLNVLRRVPDAPQRE 1670 Query: 1621 KKLDEADQILRARLNFQGTRMGFSNEEGDYWWWLMSSGDANANRLILLELNNPAWREDMP 1680 ++L EA QIL++RL++QGT++ FS E+ DYWWWLM +GD N RL+L +++PAW++DM Sbjct: 1671 QRLAEATQILKSRLSYQGTKLVFSTEQDDYWWWLMQNGDVNTARLMLAVMDDPAWKDDMG 1730 Query: 1681 RLIAGAIGRQQRGHWSTTTANVWGSLALEKFARKFESEPVTGATRATLEQN--------- 1731 RL G I RQQ G W TTTAN+WG LALEKF+ KFE+ PVTG TRA + N Sbjct: 1731 RLANGFIARQQGGAWHTTTANLWGGLALEKFSAKFEATPVTGFTRAAMGSNTATVDWSKV 1790 Query: 1732 ------GASAATQSLAWSGAP-------NGGKLQLPWPEGNAQGG--SVRLAQEGNGKPW 1776 A+ A W GAP N G LPW +A GG ++ + Q+G GKPW Sbjct: 1791 GRVTTASAAGAPHQTTWFGAPAAPGNLTNNGMF-LPW---SATGGKETLTVTQQGTGKPW 1846 Query: 1777 VTLQSLAAVPLKQPFAAGYRITRKVEAIEQKQAGVYTRGDVLRVTLDIDAQAEMTWVVVS 1836 +TLQS+AAV LK PF+AGY + + V +EQ AG YTRGDVLRV L++ + A+MTWVV++ Sbjct: 1847 LTLQSVAAVQLKAPFSAGYTVRKTVTPVEQAVAGRYTRGDVLRVKLEVTSTADMTWVVLT 1906 Query: 1837 DPVPGGATLLGSGLGRDSAIA-QGKQDAPRERGMGWLAYEERSFEAYRAYYEAMPKGRTS 1895 DPVP GAT+LG+GLGRDS IA QG++ G GW+AYEERSFEA+R YYE + KG + Sbjct: 1907 DPVPAGATILGNGLGRDSEIATQGEKRG--SGGSGWMAYEERSFEAWRGYYEYVSKGTLT 1964 Query: 1896 ISYTVRLNNAGEFNLPPTRVEAMYAPEMFGEVPNGKLVVKAAQ 1938 YTVRLNN GEF LPPTRVEAMYAPEMFGE PN ++ V+AA+ Sbjct: 1965 AEYTVRLNNVGEFALPPTRVEAMYAPEMFGETPNPRMKVEAAR 2007 >F0Q8B4.1 F0Q8B4_ACIAP Alpha-2-macroglobulin domain protein 2 Length = 2010 Score = 1920 bits (4974), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1029/2028 (50%), Positives = 1337/2028 (65%), Gaps = 154/2028 (7%) Query: 24 AASATVQSFSPQGEVQRIRQVRARFSESMVKFGDPKAASPFDADC---AVAGTARWADDK 80 A + +V SFSPQGEV R+RQV +F + V FGDPKA +PF DC A GT RW ++ Sbjct: 24 AQALSVSSFSPQGEVARVRQVVVKFDAAAVNFGDPKAPAPFSVDCGGDASRGTGRWTGER 83 Query: 81 NWVYDFERDLPPGTRCSFTLRAEAKSVAGNSVGGKTRFQFSTGGPAVSRVQPYSGAQIAE 140 WVYDF DLPPGTRC+ T R+ KS +G+++ G R+QF+TGGP V V+P + I E Sbjct: 84 EWVYDFAADLPPGTRCTATARSGFKSASGSALSGTVRYQFNTGGPFVQSVRPGTYQPIDE 143 Query: 141 DQAFILFQNGPATEPSVRQHLYCEAEGINERIPAKAVGEADRKALLQQF----AKGVDPA 196 +Q F+L +GPAT SV+ +++C AE + ERIP + + +R ALL A P Sbjct: 144 EQFFLLQLSGPATLESVKANVWCVAEDVGERIPVRLIEGTERAALLTSLGLESAAKQAPL 203 Query: 197 SVTIVQCQQRLPNEAHVKLVWDRGIAAANAPAVVTSQPQVFNFQVRSEFAASLSCQRENA 256 + C +RL + + V+LV+ +G+A + V + + + + VR F+A C+RENA Sbjct: 204 RYASLACNRRLTSGSKVQLVYGQGVATPSG--VPNTVERRYGYTVREPFSAEFGCERENA 261 Query: 257 NAACSPILPVTLSFSAPVPRKLAEQVVMNATTGKIKPTL--EGDKDEAVRELRFKPPFPE 314 AAC PI P+ LSF+APVPRKLAE + + + +KP L EGD D V ++F PPF Sbjct: 262 QAACLPIRPMRLSFNAPVPRKLAEAIRLKSDKETLKPRLDGEGDGDTVVNSVQFMPPFAP 321 Query: 315 KSDFTISLPSGFKDEDGRTLANAGAFPLKSALADFPPLAKFPAAPFGIIELNAD-----P 369 ++ + LP FKD GR L NA +FPL + PPLAKF A+PFG++E A+ Sbjct: 322 QTAMRLELPKDFKDASGRPLRNADSFPLALSTGPMPPLAKFAASPFGVVERFAEGDKGPA 381 Query: 370 TLPVTLRRVEAGLQVRG------------KDGRAMPGQVADLKVNGDKAVIAWLTRLNKY 417 LPVTLR VEA L+V+G A G+V+ + D +IAW R+ +Y Sbjct: 382 LLPVTLRNVEADLRVQGLAAGAAPGASAPAAAPAPAGKVSTFQPTADADIIAWYRRVRRY 441 Query: 418 HEKWGDPKK--------------------VDTRSVSLLAKESGAKKLDLPAQKDAKDGEW 457 + ++ V +R VSLL + A+ LDLP + A Sbjct: 442 DDYLVTRREASRDVRGPLPQVLQDEGKDTVQSRMVSLLGGQPRARVLDLP--RPASGDPR 499 Query: 458 PFEVIGIPLKDPGFYVVELESQKLGASLL----GKPQPMYVRTSALVTNLSVHVKLGRAN 513 PFEV+GIPL PGF+VVE+ S LG SLL G + MYVRTSALVTNL VH KLGR N Sbjct: 500 PFEVVGIPLP-PGFHVVEIASPMLGRSLLDERHGAGRTMYVRTSALVTNLGVHFKLGREN 558 Query: 514 GAVWVTRLDDAKPVADAEIRVSNCDGAQIWQGKTNASGVAMMPALED---ACANRGYSPD 570 A WVT LD + V A +RVS CDG ++ T+A G+A L +C R D Sbjct: 559 AAAWVTTLDKGQVVPGAVVRVSGCDGRELATATTDAQGIARFEGLSPQPPSCPGR----D 614 Query: 571 NADKINGLFVSARKTDEKGRQDMAFALTSWNEGIESWRFNLPTDMDKSATVRATTVFDRT 630 + +N FVSAR G QDMAF + W GIE WRFN+PT A T+FDRT Sbjct: 615 GLEGMNAYFVSARAQGADGVQDMAFTWSDWQRGIEPWRFNVPTSSQPEPDQIAHTIFDRT 674 Query: 631 LFRAGETVSMKHVIRTETLQGFGLMRKEDLPTRVRISHLGSGQQYQFPLTWR----GNKS 686 L RAGETVSMKH++RT+ QGFGL + P + I+H+GSGQQ+ PL WR G S Sbjct: 675 LLRAGETVSMKHILRTQNRQGFGLPDAQ--PHTLAITHVGSGQQFTQPLQWRRTPTGGLS 732 Query: 687 AETTFVLPKQAKLGSYEVVLDQGKVDANASAEPPEQSDDGDYEGGYGRGTYVTGSFRVEE 746 AE+TF LP AKLG Y V E D D G ++ +G FRVEE Sbjct: 733 AESTFALPPAAKLGVYSV----------------ELRGDDDSRGR----SFTSGEFRVEE 772 Query: 747 FRLPLMQGRITPP-KGAQVAVKEMPLDLQLNYINGGAAANQAVQVSSLLRSRSLNIAGYD 805 FRLP+++GRI P K V + +P D+Q+NY++GG AAN V+VS+L+R + L +D Sbjct: 773 FRLPVLEGRIAPADKKPLVRPRSVPTDVQVNYVSGGGAANLPVRVSALVRGKPLQFPDFD 832 Query: 806 GFSFDAPR-------------SDEDSNADDQKIVADKLAITLDKNGAGRATISKLPALQR 852 FSF+ PR +E ++ADD +++ADKLA+TLD+NGAG+ I +P +R Sbjct: 833 AFSFEPPRRKGAQPQGGNSGDDEEPASADDARVIADKLAVTLDRNGAGKVAIDNIPNSRR 892 Query: 853 PQELLTEMTYSDPNGEVQTISNVTPLWPSAVVVGLRTGNWVSVKKKLTLTAVTLNTAGQP 912 Q+L+ E TYSDPNGEVQT+ + +WP+AVV G++T WVS +K+ A+ L G+ Sbjct: 893 AQDLVLEATYSDPNGEVQTLRSTQTVWPAAVVAGIKTEGWVSAAQKIRFQALALGLDGKV 952 Query: 913 QAGVPVEIRGTARKTNSHRKRMVGGFYAYENDETKQDLGKLCSGKSDQHGMFTCDTELSE 972 Q GVP++++ AR T + RKRMVGGFY+Y+N +DLG +C+GKSD G+ C+ +L E Sbjct: 953 QEGVPMQVQAVARITTTSRKRMVGGFYSYDNKTETKDLGTVCTGKSDSRGLVLCEAKLDE 1012 Query: 973 AGNVELIASAKDGNGNAAAARSSVWVTGRGEVWFDGENQDRIDILPEKKNYQPGETANFQ 1032 AG VEL+A+A+D +GN + A +SVWVT +GE+WF GE+ DRID+LPEKK+YQPGETA Q Sbjct: 1013 AGEVELVATARDKDGNQSEAAASVWVTRQGELWFGGEDHDRIDLLPEKKSYQPGETARLQ 1072 Query: 1033 VRMPFRSATALVAVEREGVIDTRVVQLSGQDPTISVPMKAEYGPNVYVSVLAVRGRMREV 1092 VRMPFR ATALV+VEREG+ID VVQL+GQDPT+ + ++ +GPNVYVSVLA+RGR+REV Sbjct: 1073 VRMPFRQATALVSVEREGIIDMHVVQLNGQDPTVQLKIEEGWGPNVYVSVLALRGRLREV 1132 Query: 1093 PWYSFFIWGWKEPINW----WHEFREYQGPGPIVDLSKPAWKFGIAEVNVGDAGHRLQVA 1148 PWYSFF WG+K P W W+E +EY P +VDLSKPA++ G+AE+ VG HR++V Sbjct: 1133 PWYSFFTWGFKAPREWWTAFWYEGKEYVAPTAMVDLSKPAYRLGLAEIKVGAKAHRIEVK 1192 Query: 1149 VSTDKPTYPIRAIAKVQVQVKLPNGKPAAGGEFALAAVDEALLELQPNGSWDVLHAMLQR 1208 V+ DK +YP+R A+V + LP+GKPAA E A+AAVD+ALLEL PN SW++L AMLQR Sbjct: 1193 VTADKESYPVRGKAQVTIAATLPDGKPAANAEVAVAAVDQALLELMPNTSWNLLDAMLQR 1252 Query: 1209 RSYGVETSTAQMQVVGKRHYGKKATPAGGGGGRAPTRELFDTLLVWKPNVTLDAEGRAQL 1268 R++GVETSTAQM+++G+RHYGKKA PAGGGGGRA TREL DTLL+W+P V LDA GRAQ+ Sbjct: 1253 RAWGVETSTAQMEIIGRRHYGKKAVPAGGGGGRAQTRELLDTLLLWQPAVRLDANGRAQV 1312 Query: 1269 DVPLNDALTSFRIVAIAENGISDFGTGSISIRSTQDVQVISGLPPLVREGDSFNGAVTVR 1328 VPLNDALT+F+IVA+A+ G FGTGS SIR+TQD+Q+ISGLPPLVRE D F T+R Sbjct: 1313 TVPLNDALTTFKIVAVADAGTGQFGTGSTSIRATQDLQIISGLPPLVREDDQFRAQFTLR 1372 Query: 1329 NTTTHDMTIKVAARAQGGTATSTLTLPEREVKIAAGQSAEVMWPVQTPEGINQ-----LA 1383 NTT M ++VA RA + L L ++ V I AG+S EV W V P + + + Sbjct: 1373 NTTKAAMKVEVAPRA------TLLALDKQTVDIPAGESREVAWNVTAPAQLARTRAEAIL 1426 Query: 1384 WEISAQEQ--GGQKARDAMKFTQRVVPAVPVTVQQATLFQLDKNAALDVARPADSLPGRG 1441 WEI A++ G ARDA+K TQR+VPAVP+TVQQATL Q+D + +DV PAD++PGRG Sbjct: 1427 WEIEARDTTPGAAGARDALKATQRLVPAVPLTVQQATLVQVDGSFGIDVKPPADAIPGRG 1486 Query: 1442 GLAISLKPSLAGGSDALTRYFVNYPFACLEQKTSKAIGLRDEAAWQKIVADLPTYLDGDG 1501 GL +S++P LA G + +F NYPF CLEQKTSKA+GLRD WQ +V LPTYLDGDG Sbjct: 1487 GLKMSVQPKLAEGLPGVRDWFANYPFLCLEQKTSKAVGLRDGKMWQTVVGQLPTYLDGDG 1546 Query: 1502 LAYYFPPSDSGARRGSDTLTAYLLAATNEA-----GYAIPQASRDKMLDGLAAFVEGKVM 1556 LA YFPP RGSDTLTAYLLAAT+EA +A+ R M GL AFVEG++ Sbjct: 1547 LASYFPPQAGSGNRGSDTLTAYLLAATHEASSIDPAFALSPEVRAPMERGLIAFVEGRIQ 1606 Query: 1557 RDFWSPQKDLDVRKLAALEALSRYNRVQPAMLGSLQINPNVWPTSGLLDWIAILQRVPAI 1616 RDFWSP+KDLD+RKLAA+EALSRY + ML S+ + PN WPT ++DW+ IL+RV Sbjct: 1607 RDFWSPRKDLDMRKLAAIEALSRYGKATGRMLSSITVAPNQWPTHSVIDWLNILRRVTDA 1666 Query: 1617 PDRQKKLDEADQILRARLNFQGTRMGFSNEEGDYWWWLMSSGDANANRLILLELNNPAWR 1676 P R++++ EA QIL++RL++QGT++ FS+E+ DYWWWLM +GD N RL+L +++PAW+ Sbjct: 1667 PQREQRMAEATQILKSRLSYQGTKLIFSSEQDDYWWWLMQNGDVNTARLMLAVMDDPAWK 1726 Query: 1677 EDMPRLIAGAIGRQQRGHWSTTTANVWGSLALEKFARKFESEPVTGATRATLEQNGAS-- 1734 +DM RL G I RQQ G W TTTAN+WG LALEKF+ KFE+ PVTG TRA + N AS Sbjct: 1727 DDMGRLANGFIARQQGGAWHTTTANLWGGLALEKFSAKFEATPVTGFTRAAMGGNTASVD 1786 Query: 1735 -------------AATQSLAWSGAP-------NGGKLQLPWPEGNAQGG--SVRLAQEGN 1772 A W GAP N G LPW +A GG ++ + Q+G Sbjct: 1787 WSKVGRVSTADATGAVHQTTWFGAPASPGNLTNNGMF-LPW---SASGGKETLNVTQQGT 1842 Query: 1773 GKPWVTLQSLAAVPLKQPFAAGYRITRKVEAIEQKQAGVYTRGDVLRVTLDIDAQAEMTW 1832 GKPW+TLQS+AAV LK+PF+AGY + + + +EQ AG YTRGDVLR+ L++ + A+MTW Sbjct: 1843 GKPWLTLQSVAAVQLKEPFSAGYTVKKTITPVEQAVAGRYTRGDVLRIKLEVTSTADMTW 1902 Query: 1833 VVVSDPVPGGATLLGSGLGRDSAIA-QG-KQDAPRERGMGWLAYEERSFEAYRAYYEAMP 1890 VV++DPVPGGAT+LG+GLGRDS IA QG K+ + G GWLAYEERSFEA+R YYE + Sbjct: 1903 VVLTDPVPGGATILGNGLGRDSEIATQGEKRGSGGSGGSGWLAYEERSFEAWRGYYEYVS 1962 Query: 1891 KGRTSISYTVRLNNAGEFNLPPTRVEAMYAPEMFGEVPNGKLVVKAAQ 1938 KG + YTVRLNN GEF LPPTRVEAMYAPEMFGE PN ++ V+AA+ Sbjct: 1963 KGSLTAEYTVRLNNVGEFALPPTRVEAMYAPEMFGETPNPRMKVEAAR 2010