BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0035.0108.p (670 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IZS2.1 D8IZS2_HERSS Uroporphyrinogen-III synthase protein EC=4... 522 e-145 A6SX36.1 A6SX36_JANMA Uroporphyrinogen-III synthase EC=4.2.1.75 208 3e-51 F1VWN3.1 F1VWN3_9BURK Uroporphyrinogen III synthase 204 5e-50 A4G3V3.1 A4G3V3_HERAR Uroporphyrinogen III synthase (UROS) (Urop... 201 2e-49 B1FY92.1 B1FY92_9BURK Putative uncharacterized protein 170 8e-40 B2JEN8.1 B2JEN8_BURP8 Putative uncharacterized protein 169 2e-39 A3RYV4.1 A3RYV4_RALSO UROPORPHYRINOGEN-III SYNTHASE / Uroporphyr... 168 3e-39 D8NR30.1 D8NR30_RALSO Probable bifunctional: uroporphyrin-III c-... 167 4e-39 D8P0A2.1 D8P0A2_RALSO Probable bifunctional: uroporphyrin-III c-... 167 5e-39 B5S1L0.1 B5S1L0_RALSO Bifunctional protein: uroporphyrin-III c-m... 167 5e-39 >D8IZS2.1 D8IZS2_HERSS Uroporphyrinogen-III synthase protein EC=4.2.1.75 Length = 269 Score = 522 bits (1344), Expect = e-145, Method: Compositional matrix adjust. Identities = 257/257 (100%), Positives = 257/257 (100%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN Sbjct: 13 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 72 Query: 61 AIDAAFAQLPAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQRADKMDSEELLK 120 AIDAAFAQLPAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQRADKMDSEELLK Sbjct: 73 AIDAAFAQLPAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQRADKMDSEELLK 132 Query: 121 SLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLLDLL 180 SLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLLDLL Sbjct: 133 SLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLLDLL 192 Query: 181 DGGADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETAREQGFERVVLT 240 DGGADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETAREQGFERVVLT Sbjct: 193 DGGADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETAREQGFERVVLT 252 Query: 241 GSGDERLLAALAAPAAV 257 GSGDERLLAALAAPAAV Sbjct: 253 GSGDERLLAALAAPAAV 269 >A6SX36.1 A6SX36_JANMA Uroporphyrinogen-III synthase EC=4.2.1.75 Length = 256 Score = 208 bits (529), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 120/251 (47%), Positives = 158/251 (62%), Gaps = 3/251 (1%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 VV+TRP QA A A V LGR AV+FPLLEI ++D +L+ L L+++AL+ FVSPN Sbjct: 5 VVITRPLAQADALAQRVTELGRKAVIFPLLEILPLDDQQSLRQALRELDQYALIAFVSPN 64 Query: 61 AIDAAFAQLPAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQRADKMDSEELLK 120 AIDAAF P WP ++ + +VGEGSR+AL HG +T+ P ++ DS+ LL Sbjct: 65 AIDAAFNARP---DWPWQIPLAVVGEGSRMALLRHGATTGNSTIISPTDLERTDSQTLLA 121 Query: 121 SLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLLDLL 180 L L LRG++ LI+RG++GR+ L + L+ GV V L AYRR AP L+ L LL Sbjct: 122 ELDLPVLRGKQVLIIRGETGRELLGDTLRAAGVGVTPLAAYRRVAPELNNARRGELKRLL 181 Query: 181 DGGADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETAREQGFERVVLT 240 DW++TSSE LR L ++ V K+Q+QRI VSH RIAETA+ GF + LT Sbjct: 182 SCQNDWIVTSSEGLRFLTEMVAQLDEAGSVAKMQQQRIIVSHVRIAETAQLLGFSNITLT 241 Query: 241 GSGDERLLAAL 251 SGD+ LLAAL Sbjct: 242 RSGDDGLLAAL 252 >F1VWN3.1 F1VWN3_9BURK Uroporphyrinogen III synthase Length = 256 Score = 204 bits (518), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 126/251 (50%), Positives = 164/251 (65%), Gaps = 3/251 (1%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 +V+TRP Q+ A A ++ R V+ PLLEI + D + LQA+LA+LE FALV FVSPN Sbjct: 5 LVITRPLAQSLALAQQLRDGDRELVILPLLEILPLPDTSALQAVLAQLESFALVAFVSPN 64 Query: 61 AIDAAFAQLPAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQRADKMDSEELLK 120 AIDA FAQL WP V + ++GEGSR AL HGV A + P + DS+ LL+ Sbjct: 65 AIDATFAQLAC---WPPSVPLAVMGEGSRRALARHGVAAGLYQITSPLDTQRTDSQTLLE 121 Query: 121 SLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLLDLL 180 +L L++L+G++ LIVRG+SGR+ L++AL+ G++V+ + AYRR AP LD L DLL Sbjct: 122 ALDLSRLQGRQVLIVRGESGRELLADALRDAGISVQQVAAYRRAAPLLDDALRQRLTDLL 181 Query: 181 DGGADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETAREQGFERVVLT 240 DWVITSSEAL+ L+ + E V K+QR ++FV H RIAETA GF V LT Sbjct: 182 AQEGDWVITSSEALQVLMHFVQQVDAESGVDKIQRMKLFVPHRRIAETALSLGFRSVCLT 241 Query: 241 GSGDERLLAAL 251 GSGDE LL AL Sbjct: 242 GSGDEGLLTAL 252 >A4G3V3.1 A4G3V3_HERAR Uroporphyrinogen III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) EC=4.2.1.75 Length = 260 Score = 201 bits (512), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 126/251 (50%), Positives = 154/251 (61%), Gaps = 3/251 (1%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 VV+TRP QA A V ALGR A VFPLL+I + D A+LQ L L +AL+ FVSPN Sbjct: 9 VVITRPLAQAEGLARRVTALGRKATVFPLLDILPLADQASLQQALRDLSGYALIAFVSPN 68 Query: 61 AIDAAFAQLPAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQRADKMDSEELLK 120 A A L A WP + + +VGEGSRLAL HG+ A +T+ P D+ DSE LL Sbjct: 69 A---IDAALAARADWPRDIPMAVVGEGSRLALARHGLTAENSTIISPTDLDRTDSETLLA 125 Query: 121 SLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLLDLL 180 L L LR ++ LIVRG++GR LSEAL+ G V L AYRR AP DA L LL Sbjct: 126 ELDLPALRNKQILIVRGETGRPLLSEALRAAGAQVTLLAAYRRVAPVFDATRRRELKRLL 185 Query: 181 DGGADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETAREQGFERVVLT 240 G DW++TSSEALR L+ + E V K+Q+QRI VSH RI ETA+ GF + +T Sbjct: 186 HGQNDWIVTSSEALRFLMQMVAQLDEAEGVAKMQQQRIIVSHIRIGETAQLLGFSNITVT 245 Query: 241 GSGDERLLAAL 251 SGD+ LLAAL Sbjct: 246 RSGDDGLLAAL 256 >B1FY92.1 B1FY92_9BURK Putative uncharacterized protein Length = 677 Score = 170 bits (430), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 126/322 (39%), Positives = 177/322 (54%), Gaps = 34/322 (10%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 VV+TRP Q++ + A G + FPL++I+ VED A L+A L LE +ALVVFVSPN Sbjct: 25 VVITRPAGQSNELIERLAAAGAVTLDFPLIDIAPVEDDAPLRAALGSLERYALVVFVSPN 84 Query: 61 AIDAAFAQLPAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGP-QRADK----MDS 115 AID AFA+ +G WP + +G+VG GS AL HGV+A + P AD+ DS Sbjct: 85 AIDHAFAR--SGAIWPHALPVGVVGPGSVRALARHGVNAPAHQVISPASDADEDNGRFDS 142 Query: 116 EELL----KSLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQ 171 E L +L A L G+R LIVRG GR++L++ L++ G VE + AYRR P Sbjct: 143 EGLFAAIDAALGEANLEGKRVLIVRGDGGREWLADRLREAGAEVETVAAYRRLVPEPSIA 202 Query: 172 NGPLLLDLLDGG-ADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETAR 230 + LL G W++TSSE +RNL +L + + + +L+R I H RIA+TAR Sbjct: 203 AWARVHRLLAGEPHAWLLTSSEGVRNLHELAQEHLTADEIAQLKRAPIVAPHPRIAQTAR 262 Query: 231 EQGFERVVLTGSGDERLLAALAAPAAV*AV*FAALQSCP*PNSNPPPNCRSLSR------ 284 GF+R+ ++G+GDER+ AL AAL + P S+ P + + SR Sbjct: 263 ALGFDRITVSGAGDERIAQAL----------LAALPTVVQPVSSNPAHSPAQSRMTETNA 312 Query: 285 ------KPARLLARPPRRPPTP 300 +PA + PP +P TP Sbjct: 313 STNASPQPAATASLPPNQPFTP 334 >B2JEN8.1 B2JEN8_BURP8 Putative uncharacterized protein Length = 686 Score = 169 bits (427), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 117/282 (41%), Positives = 154/282 (54%), Gaps = 28/282 (9%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 VV+TRP Q+ A A ++ G V FPL+EI+A +D L+A LA LE++ALVVFVSPN Sbjct: 30 VVLTRPAGQSEALARTLHDAGVATVEFPLIEIAATDDATPLRAALASLEKYALVVFVSPN 89 Query: 61 AIDAAFAQLPAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGP-----QRAD--KM 113 A+D AFA A WP + IG+VG GS AL HGV+A + P D + Sbjct: 90 AVDYAFANHDA--IWPHALPIGVVGPGSVAALAKHGVEAPAYQVISPGAAADDNGDGARF 147 Query: 114 DSEELLKSLPLA----QLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAP--- 166 DSE L +L + G+R LIVRG GR++L+E L++ G VE + AYRR P Sbjct: 148 DSEALYSALEASLGDNAFEGKRVLIVRGDGGREWLAERLREAGAEVETVAAYRRLVPEPS 207 Query: 167 -----RLDAQNGPLLLDLLDGGADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVS 221 R+ A LL D W++TSSE RNL +L L+R Sbjct: 208 IGAWSRIHA----LLSDTSTARHAWLLTSSEGARNLAELAHDHLTNSEQTHLKRAMFVAP 263 Query: 222 HHRIAETAREQGFERVVLTGSGDERL---LAALAAPAAV*AV 260 H RIAETAR GF+ + ++G+GDER+ L +LA P V AV Sbjct: 264 HPRIAETARALGFDSITVSGAGDERIARTLLSLATPPVVQAV 305 >A3RYV4.1 A3RYV4_RALSO UROPORPHYRINOGEN-III SYNTHASE / Uroporphyrin-III C-methyltransferase EC=2.1.1.107 EC=4.2.1.75 Length = 1065 Score = 168 bits (425), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 109/249 (43%), Positives = 144/249 (57%), Gaps = 3/249 (1%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 VVVTRPR QA A+++ G + FPLL+I+ ++ L+A LA +ALVVFVSPN Sbjct: 394 VVVTRPRAQALMLVAALERHGLRTLQFPLLDIAPTPNLDDLRAALADPSRYALVVFVSPN 453 Query: 61 AIDAAFAQLPAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQ-RAD--KMDSEE 117 A+ AFA +P G WP V + +VG S AL AHGV+ ++ P AD + DSE Sbjct: 454 AVQQAFAAMPEGFRWPQDVPVAVVGPASAQALAAHGVEPPTHSVIRPDVHADDARQDSEA 513 Query: 118 LLKSLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLL 177 L L AQL G+ LIVRG GR++L++ L++ GV V + AYRR+ P DA L Sbjct: 514 LYARLDPAQLSGREVLIVRGNGGREWLADRLREAGVAVRTVEAYRRSVPVPDAAAWAALR 573 Query: 178 DLLDGGADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETAREQGFERV 237 ++L G W +TSSEA+RNL L R + V L F H RI E A+ GF V Sbjct: 574 EVLAGRHAWTLTSSEAVRNLDSLARASLTAAEVDTLHAAPCFAPHARIVEQAQSLGFRDV 633 Query: 238 VLTGSGDER 246 LTG+GD+R Sbjct: 634 TLTGAGDDR 642 >D8NR30.1 D8NR30_RALSO Probable bifunctional: uroporphyrin-III c-methyltransferase and uroporphyrinogen-III synthase transmembrane protein EC=2.1.1.107 EC=4.2.1.75 Length = 704 Score = 167 bits (424), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 112/254 (44%), Positives = 148/254 (58%), Gaps = 3/254 (1%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 VVVTRPR QA A+++ G + FPLL+I+ ++ L+A LA +ALVVFVSPN Sbjct: 30 VVVTRPRAQAPMLVAALERHGLRTLQFPLLDIAPTPNLDDLRAALADPSRYALVVFVSPN 89 Query: 61 AIDAAFAQLPAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQ-RAD--KMDSEE 117 A+ AF+ +P G WP V + +VG S AL AHGV+ ++ P AD + DSE Sbjct: 90 AVQQAFSAMPEGFRWPQDVPVAVVGPASAQALAAHGVEPPTHSVIRPDTHADDARQDSEA 149 Query: 118 LLKSLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLL 177 L L AQL G+ LIVRG GR++L++ L++ GV V + AYRR+ P DA L Sbjct: 150 LYARLDPAQLSGREVLIVRGNGGREWLADRLREAGVAVRTVEAYRRSVPVPDAAAWAALR 209 Query: 178 DLLDGGADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETAREQGFERV 237 ++L G W +TSSEA+RNL L R + V L F H RI E A+ GF V Sbjct: 210 EVLAGRHAWTLTSSEAVRNLDSLARASLTAAEVDTLHAAPCFAPHARIVEQAQSLGFRDV 269 Query: 238 VLTGSGDERLLAAL 251 LTG+GD+RLLA L Sbjct: 270 TLTGAGDDRLLAGL 283 >D8P0A2.1 D8P0A2_RALSO Probable bifunctional: uroporphyrin-III c-methyltransferase and uroporphyrinogen-III synthase transmembrane protein EC=2.1.1.107 EC=4.2.1.75 Length = 697 Score = 167 bits (424), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 113/256 (44%), Positives = 148/256 (57%), Gaps = 3/256 (1%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 VVVTRPR QA A+++ G + FPLL+I+ ++ L+A LA +ALVVFVSPN Sbjct: 24 VVVTRPRTQAPMLVAALERHGLRTLQFPLLDIAPTPNLDDLRAALADPSRYALVVFVSPN 83 Query: 61 AIDAAFAQLPAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQ-RADK--MDSEE 117 A+ AF+ +P G WP V + +VG S AL AHGV+ + P AD+ DSE Sbjct: 84 AVQQAFSAMPEGFRWPQDVPVAVVGPASAQALAAHGVEPPTYRVIRPDSHADEARQDSEA 143 Query: 118 LLKSLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLL 177 L L LA L G+ LIVRG GR++L++ L++ GV V + AYRR+ P DA L Sbjct: 144 LYARLDLAPLSGREMLIVRGNGGREWLADRLREAGVAVRTVEAYRRSVPVPDAATWAALR 203 Query: 178 DLLDGGADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETAREQGFERV 237 ++L G W +TSSEA+RNL L R + V L F H RI E A+ GF V Sbjct: 204 EVLAGRHAWTLTSSEAVRNLDSLARASLTAAEVDTLHAAPCFAPHARIVEQAQSLGFHDV 263 Query: 238 VLTGSGDERLLAALAA 253 LTG+GD+RLLA L A Sbjct: 264 TLTGAGDDRLLAGLLA 279 >B5S1L0.1 B5S1L0_RALSO Bifunctional protein: uroporphyrin-III c-methyltransferase and uroporphyrinogen-III synthase EC=2.1.1.107 EC=4.2.1.75 Length = 715 Score = 167 bits (423), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 113/256 (44%), Positives = 149/256 (58%), Gaps = 3/256 (1%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 VVVTRPR QA A+++ G + FPLL+I+ ++ L+A LA +ALVVFVSPN Sbjct: 45 VVVTRPRAQAPMLVAALERHGLRTLQFPLLDIAPTPNLDDLRAALADPSRYALVVFVSPN 104 Query: 61 AIDAAFAQLPAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQ-RAD--KMDSEE 117 A+ AF+ +P G WP V + +VG S AL AHGV+ ++ P AD + DSE Sbjct: 105 AVQQAFSAMPEGFRWPQDVPVAVVGPASAQALAAHGVEPPTHSVIRPDVHADDARQDSEA 164 Query: 118 LLKSLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLL 177 L L AQL G+ LIVRG GR++L++ L++ GV V + AYRR+ P DA L Sbjct: 165 LYARLDPAQLSGREVLIVRGNGGREWLADRLREAGVAVRTVEAYRRSVPVPDAAAWAALR 224 Query: 178 DLLDGGADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETAREQGFERV 237 ++L G W +TSSEA+RNL L R + V L F H RI E A+ GF V Sbjct: 225 EVLAGRHAWTLTSSEAVRNLDSLARASLTAAEVDTLHAAPCFAPHARIVEQAQSLGFRDV 284 Query: 238 VLTGSGDERLLAALAA 253 LTG+GD+RLLA L A Sbjct: 285 TLTGAGDDRLLAGLLA 300