BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0031.0324.p (292 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IUP1.1 D8IUP1_HERSS Bifunctional: biotin operon repressor/biot... 503 e-140 A6T333.1 A6T333_JANMA Bifunctional biotin operon repressor /biot... 231 7e-59 A4G9B4.1 A4G9B4_HERAR Putative bifunctional protein birA EC=6.3.... 225 6e-57 F1VYQ5.1 F1VYQ5_9BURK Biotin-protein ligase 224 2e-56 B2JKK8.1 B2JKK8_BURP8 Biotin--acetyl-CoA-carboxylase ligase 173 3e-41 E8YL98.1 E8YL98_9BURK Biotin/acetyl-CoA-carboxylase ligase 171 9e-41 B5WUA6.1 B5WUA6_9BURK Biotin/acetyl-CoA-carboxylase ligase 171 1e-40 E1T5V6.1 E1T5V6_BURSG Biotin/acetyl-CoA-carboxylase ligase 171 1e-40 B1FVW1.1 B1FVW1_9BURK Biotin--acetyl-CoA-carboxylase ligase 171 2e-40 B2SWX1.1 B2SWX1_BURPP Biotin/acetyl-CoA-carboxylase ligase 170 2e-40 >D8IUP1.1 D8IUP1_HERSS Bifunctional: biotin operon repressor/biotin-[acetyl-CoA-carboxylase] synthetase protein EC=6.3.4.15 Length = 257 Score = 503 bits (1295), Expect = e-140, Method: Compositional matrix adjust. Identities = 255/257 (99%), Positives = 255/257 (99%) Query: 36 MLLAGSDSQGQQRIDVEAVACTGSTNVDLMQRVTSLTRPLLLVADRQTAGRGRAGRPWRA 95 MLLAGSDSQGQQRIDVEAVACTGSTNVDLMQRVTSLTRPLLLVADRQTAGRGRAGRPWRA Sbjct: 1 MLLAGSDSQGQQRIDVEAVACTGSTNVDLMQRVTSLTRPLLLVADRQTAGRGRAGRPWRA 60 Query: 96 APEDSLTFSLAWRFERPMHALLGLPLAVGVALAEALEVFGVRPQLKWPNDVLREGAKLAG 155 APEDSLTFSLAWRFERPMHALLGLPLAVGVALAEALEVFGVRPQLKWPNDVLREGAKLAG Sbjct: 61 APEDSLTFSLAWRFERPMHALLGLPLAVGVALAEALEVFGVRPQLKWPNDVLREGAKLAG 120 Query: 156 ILIETASDGRRGDATWAVIGIGLNLGVPQGLEQELQRAIAAVPELRKPPRETVLAIIASA 215 ILIETASDGRRGDATWAVIGIGLNLGVPQGLEQELQRAIAAVPELRKPPRETVLAIIASA Sbjct: 121 ILIETASDGRRGDATWAVIGIGLNLGVPQGLEQELQRAIAAVPELRKPPRETVLAIIASA 180 Query: 216 LAEVLTEFEQRGFGAFVRRWETFHAYADQAVKIVDNGRLLHEGRAVGVDMMGRFLLDTEA 275 LAEVLTEFEQRGFGAFVRRWE FHAYA QAVKIVDNGRLLHEGRAVGVDMMGRFLLDTEA Sbjct: 181 LAEVLTEFEQRGFGAFVRRWEAFHAYAGQAVKIVDNGRLLHEGRAVGVDMMGRFLLDTEA 240 Query: 276 GQVAVMVGDLSLRLQDG 292 GQVAVMVGDLSLRLQDG Sbjct: 241 GQVAVMVGDLSLRLQDG 257 >A6T333.1 A6T333_JANMA Bifunctional biotin operon repressor /biotin--[acetyl-CoA-carboxylase] synthetase EC=6.3.4.15 Length = 307 Score = 231 bits (590), Expect = 7e-59, Method: Compositional matrix adjust. Identities = 135/267 (50%), Positives = 168/267 (62%), Gaps = 5/267 (1%) Query: 26 TPLVRPERIGMLLAGSDSQGQQRIDVEAVACTGSTNVDLMQRVTSLTRPLLLVADRQTAG 85 TPL +R LAG + Q I +E VA TGSTN DL+ R L +P LL A QTAG Sbjct: 46 TPLPSAQR----LAGLCTNAAQAIALEIVAETGSTNADLLARAPHLQQPTLLWAQVQTAG 101 Query: 86 RGRAGRPWRAAPEDSLTFSLAWRFERPMHALLGLPLAVGVALAEALEVFGVRPQLKWPND 145 +GRAGR W +LTFSLAW+F P+ LLGLPLAVGV +AEAL FGV +LKWPND Sbjct: 102 KGRAGRAWHTPAGAALTFSLAWKFNLPLQGLLGLPLAVGVVIAEALRTFGVDARLKWPND 161 Query: 146 VLREGAKLAGILIETASDGRRGDATWAVIGIGLNLGVPQGLEQELQRAIAAVPELRKPPR 205 VL++ KLAGILIET +D A+W VIG+G+N+ L + RA+ A EL P Sbjct: 162 VLKDDGKLAGILIETVADKSGQPASWVVIGVGINIARASDLSAQTGRAVVAATELAAEP- 220 Query: 206 ETVLAIIASALAEVLTEFEQRGFGAFVRRWETFHAYADQAVKIVDNGRLLHEGRAVGVDM 265 E +A + A+ L FEQ GF FV W AYA QAV I+D G++LH G A GVD Sbjct: 221 ERAMAALLDGFAQALPRFEQEGFAGFVDAWNALDAYAGQAVNILDQGQVLHSGHAAGVDA 280 Query: 266 MGRFLLDTEAGQVAVMVGDLSLRLQDG 292 GR LLDT G++ V+ GD+SLR+++G Sbjct: 281 GGRLLLDTAQGRITVVAGDVSLRIREG 307 >A4G9B4.1 A4G9B4_HERAR Putative bifunctional protein birA EC=6.3.4.15 Length = 263 Score = 225 bits (574), Expect = 6e-57, Method: Compositional matrix adjust. Identities = 121/245 (49%), Positives = 155/245 (63%), Gaps = 3/245 (1%) Query: 47 QRIDVEAVACTGSTNVDLMQRVTSLTRPLLLVADRQTAGRGRAGRPWRAAPEDSLTFSLA 106 Q + + V TGSTN DL+ T L P LL A QTAG+GRAGR W +A + +LTFSLA Sbjct: 21 QNMTLRIVTETGSTNADLLAETTQLQGPTLLWAGVQTAGKGRAGRRWHSAADATLTFSLA 80 Query: 107 WRFERPMHALLGLPLAVGVALAEALEVFGVRPQLKWPNDVLREGAKLAGILIETASDGRR 166 W+F P+ AL GL LAVGV + E L FGV QLKWPNDVLR G KLAGILIETA D Sbjct: 81 WKFALPVQALAGLSLAVGVTVVETLISFGVDAQLKWPNDVLRNGNKLAGILIETAMDKTD 140 Query: 167 GDATWAVIGIGLNLGVPQGLEQELQRAIAAVPELRKPPRETVLAIIASALAEVLTEFEQR 226 + WA+IG+G+NL + L ++ R +A L R ++A + A ++ L FEQ+ Sbjct: 141 RQSIWAIIGVGINLADARNLSAQIGRTVADASGLE---RVRLMAALLDAFSKALPLFEQQ 197 Query: 227 GFGAFVRRWETFHAYADQAVKIVDNGRLLHEGRAVGVDMMGRFLLDTEAGQVAVMVGDLS 286 GF AF W AYA QAV I+D ++L G A GVD GR LLDT G++A+ GD+S Sbjct: 198 GFKAFAPAWNALDAYAGQAVNILDQEKILQHGDAAGVDEAGRLLLDTAQGRIAISAGDVS 257 Query: 287 LRLQD 291 LR+++ Sbjct: 258 LRIRE 262 >F1VYQ5.1 F1VYQ5_9BURK Biotin-protein ligase Length = 264 Score = 224 bits (570), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 126/240 (52%), Positives = 158/240 (65%) Query: 49 IDVEAVACTGSTNVDLMQRVTSLTRPLLLVADRQTAGRGRAGRPWRAAPEDSLTFSLAWR 108 + +EAVA TGSTN DL+ R+ L P+ LVAD+QTAGRGRAGR W + SLTFSLAW Sbjct: 21 LTIEAVAETGSTNADLLARLDQLHGPVFLVADQQTAGRGRAGRTWHSERGASLTFSLAWP 80 Query: 109 FERPMHALLGLPLAVGVALAEALEVFGVRPQLKWPNDVLREGAKLAGILIETASDGRRGD 168 P+ AL+GLPLAVGVALA+ L G+ QLKWPND+L +G+KLAGILIETA D + G Sbjct: 81 VRVPLQALVGLPLAVGVALADVLAGHGIAVQLKWPNDLLADGSKLAGILIETAVDRQAGA 140 Query: 169 ATWAVIGIGLNLGVPQGLEQELQRAIAAVPELRKPPRETVLAIIASALAEVLTEFEQRGF 228 WAVIGIG+NL L + + +AA+P+ R+ +LA + L L EFE+ GF Sbjct: 141 RLWAVIGIGINLTDNAALAARIGQPVAALPDAGAIDRDLLLADLLGHLCLTLQEFEEYGF 200 Query: 229 GAFVRRWETFHAYADQAVKIVDNGRLLHEGRAVGVDMMGRFLLDTEAGQVAVMVGDLSLR 288 F RW H + Q V I+D G+ + EG AVGVD GR LLDT G+ V+ GD+SLR Sbjct: 201 AVFAERWNALHTHRGQPVSIIDRGQTVCEGVAVGVDAQGRLLLDTAQGRRTVVAGDVSLR 260 >B2JKK8.1 B2JKK8_BURP8 Biotin--acetyl-CoA-carboxylase ligase Length = 319 Score = 173 bits (439), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 118/265 (44%), Positives = 145/265 (54%), Gaps = 26/265 (9%) Query: 51 VEAVACTGSTNVDLMQRVTSLTR-------PLLLVADRQTAGRGRAGRPWRAAPEDSLTF 103 +E V TGSTN DLM RV +L R P++ VA QTAGRGR GRPW A P ++L F Sbjct: 51 IEIVEETGSTNADLMARVKALPREPGALPRPIVRVAYLQTAGRGRRGRPWYAEPGNALLF 110 Query: 104 SLAWRFERPMHALLGLPLAVGVALAEALEVFGV----RPQLKWPNDVLREGAKLAGILIE 159 S+A RP+ L GL LAVGVAL + L V + LKWPNDVL EG KLAGILIE Sbjct: 111 SVACVLPRPLEGLAGLSLAVGVALVDGLRSLPVAGPGQIALKWPNDVLLEGDKLAGILIE 170 Query: 160 TASDGRRGDATWAVIGIGLNLGVPQGLEQELQRAIAAVPELRKPPRET------------ 207 TA DA+ VIGIG N+ L ++ A VP + T Sbjct: 171 TAWS--TPDASAVVIGIGTNVKGADELAAKVGALNADVPAQARGAAPTALSRALPNANLT 228 Query: 208 -VLAIIASALAEVLTEFEQRGFGAFVRRWETFHAYADQAVKIVDNGRLLHEGRAVGVDMM 266 LA +AL L F GF F +RW HAYA + V + + G + G A GVD + Sbjct: 229 DTLAAELNALEPALQRFGAEGFAPFRQRWNGCHAYAGRDVVLFEQGVEIERGVAAGVDEL 288 Query: 267 GRFLLDTEAGQVAVMVGDLSLRLQD 291 G+ LLDT +GQ+A+ GD+SLRL D Sbjct: 289 GQLLLDTPSGQLAIATGDVSLRLAD 313 >E8YL98.1 E8YL98_9BURK Biotin/acetyl-CoA-carboxylase ligase Length = 305 Score = 171 bits (434), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 117/266 (43%), Positives = 143/266 (53%), Gaps = 26/266 (9%) Query: 51 VEAVACTGSTNVDLMQRVTSLTR-------PLLLVADRQTAGRGRAGRPWRAAPEDSLTF 103 +E V TGSTN DLM RV +L R P++ VA QTAGRGR GRPW A P ++L F Sbjct: 40 IEIVEETGSTNADLMSRVKALPRRAGALPRPIVRVAYLQTAGRGRRGRPWYAEPGNALLF 99 Query: 104 SLAWRFERPMHALLGLPLAVGVALAEALEVFGV----RPQLKWPNDVLREGAKLAGILIE 159 S+A RP+ L GL LAVGVAL + L V + LKWPNDVL EG KLAGILIE Sbjct: 100 SVACVLPRPLEGLAGLSLAVGVALVDGLRSLPVAGPGQIALKWPNDVLLEGDKLAGILIE 159 Query: 160 TASDGRRGDATWAVIGIGLNLGVPQGLEQEL----------QRAIAAVPELRKPPRETVL 209 TA A VIGIG N+ L +L R A R P + Sbjct: 160 TAWSTDTASAV--VIGIGTNVKGADELAAKLGALSAETPPQARGTAPTALQRALPNANLT 217 Query: 210 AIIA---SALAEVLTEFEQRGFGAFVRRWETFHAYADQAVKIVDNGRLLHEGRAVGVDMM 266 +A +AL L F GF F RW HAYA + V +++ G + G A GVD Sbjct: 218 DTLAAELNALEPALQRFGAEGFAPFQARWNAMHAYAGREVVLLEQGHEVTRGVAAGVDER 277 Query: 267 GRFLLDTEAGQVAVMVGDLSLRLQDG 292 G+ LLDT+AG+ ++ GD+SLRL DG Sbjct: 278 GQLLLDTDAGRQSIATGDVSLRLADG 303 >B5WUA6.1 B5WUA6_9BURK Biotin/acetyl-CoA-carboxylase ligase Length = 305 Score = 171 bits (433), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 117/266 (43%), Positives = 145/266 (54%), Gaps = 26/266 (9%) Query: 51 VEAVACTGSTNVDLM-------QRVTSLTRPLLLVADRQTAGRGRAGRPWRAAPEDSLTF 103 +E V TGSTN DLM +R +L RP++ VA QTAGRGR GRPW A P ++L F Sbjct: 40 IEIVEETGSTNADLMTHVKALPRRANALPRPIVRVAYLQTAGRGRRGRPWYAEPGNALLF 99 Query: 104 SLAWRFERPMHALLGLPLAVGVALAEALEVFGV----RPQLKWPNDVLREGAKLAGILIE 159 S+A RP+ L GL LAVGVAL + L V + LKWPNDVL EG KLAGILIE Sbjct: 100 SVACVLPRPLEGLAGLSLAVGVALVDGLRSLPVAGPGQIALKWPNDVLLEGDKLAGILIE 159 Query: 160 TASDGRRGDATWAVIGIGLNLGVPQGLEQELQRAIAAVPE----------LRKPPRETVL 209 TA DA+ VIGIG N+ L ++ A VP R P + Sbjct: 160 TAWS--TDDASAVVIGIGTNVKGADELAAKVGALNAEVPPQARGTAPTALQRALPNANLT 217 Query: 210 AIIA---SALAEVLTEFEQRGFGAFVRRWETFHAYADQAVKIVDNGRLLHEGRAVGVDMM 266 +A +AL +L F GF F RW HAYA + V +++ G+ L G A GVD Sbjct: 218 DTLAAELNALEPMLQRFGAEGFAPFQPRWNAVHAYAGRDVVVLEQGQELARGVAAGVDER 277 Query: 267 GRFLLDTEAGQVAVMVGDLSLRLQDG 292 G+ LLDT G+ + GD+SLRL DG Sbjct: 278 GQLLLDTADGRQCIATGDVSLRLADG 303 >E1T5V6.1 E1T5V6_BURSG Biotin/acetyl-CoA-carboxylase ligase Length = 305 Score = 171 bits (432), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 117/266 (43%), Positives = 142/266 (53%), Gaps = 26/266 (9%) Query: 51 VEAVACTGSTNVDLMQRVTSLTR-------PLLLVADRQTAGRGRAGRPWRAAPEDSLTF 103 +E V TGSTN DLM RV +L R P++ VA QTAGRGR GRPW A P ++L F Sbjct: 40 IEIVEETGSTNADLMARVKALPRRAGALPRPIVRVAYLQTAGRGRRGRPWYAEPGNALLF 99 Query: 104 SLAWRFERPMHALLGLPLAVGVALAEALEVFGV----RPQLKWPNDVLREGAKLAGILIE 159 S+A RP+ L GL LAVGVAL + L V + LKWPNDVL EG KLAGILIE Sbjct: 100 SVACVLPRPLEGLAGLSLAVGVALVDGLRSLPVAGPGQIALKWPNDVLLEGDKLAGILIE 159 Query: 160 TASDGRRGDATWAVIGIGLNLGVPQGLEQEL----------QRAIAAVPELRKPPRETVL 209 TA A VIGIG N+ L ++ R A R P + Sbjct: 160 TAWSTEHASAV--VIGIGTNVKGADELAAKIGALTADAPPQARGTAPTALQRALPNANLT 217 Query: 210 AIIA---SALAEVLTEFEQRGFGAFVRRWETFHAYADQAVKIVDNGRLLHEGRAVGVDMM 266 +A +AL L F GF F RW HAYA + V +++ G + G A GVD Sbjct: 218 DTLAAELNALEPALQRFGAEGFAPFQARWNAMHAYAGREVVLLEQGEEVTRGVAAGVDER 277 Query: 267 GRFLLDTEAGQVAVMVGDLSLRLQDG 292 G+ LLDT AG+ +V GD+SLRL DG Sbjct: 278 GQLLLDTAAGRQSVATGDVSLRLADG 303 >B1FVW1.1 B1FVW1_9BURK Biotin--acetyl-CoA-carboxylase ligase Length = 305 Score = 171 bits (432), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 116/266 (43%), Positives = 143/266 (53%), Gaps = 26/266 (9%) Query: 51 VEAVACTGSTNVDLMQRVTSLTR-------PLLLVADRQTAGRGRAGRPWRAAPEDSLTF 103 +E V TGSTN DLM RV +L R P++ VA QTAGRGR GRPW A P ++L F Sbjct: 40 IEIVEETGSTNADLMSRVKALPRKAGALPRPIVRVAYLQTAGRGRRGRPWYAEPGNALLF 99 Query: 104 SLAWRFERPMHALLGLPLAVGVALAEALEVFGV----RPQLKWPNDVLREGAKLAGILIE 159 S+A RP+ L GL LAVGVAL + L V + LKWPNDVL EG KLAGILIE Sbjct: 100 SVACVLPRPLEGLAGLSLAVGVALVDGLRSLPVAGPGQIALKWPNDVLLEGDKLAGILIE 159 Query: 160 TASDGRRGDATWAVIGIGLNLGVPQGLEQEL----------QRAIAAVPELRKPPRETVL 209 TA A VIGIG N+ L ++ R A R P + Sbjct: 160 TAWSTEHASAV--VIGIGTNVKGADELAAKIGALNADAPPQARGTAPTALQRALPNANLT 217 Query: 210 AIIA---SALAEVLTEFEQRGFGAFVRRWETFHAYADQAVKIVDNGRLLHEGRAVGVDMM 266 +A +AL L F GF F RW HAYA + V +++ G+ + G A GVD Sbjct: 218 DTLAAELNALEPALQRFGAEGFAPFQARWNAVHAYAGREVVLLEQGQEVTRGVAAGVDER 277 Query: 267 GRFLLDTEAGQVAVMVGDLSLRLQDG 292 G+ LLDT AG+ ++ GD+SLRL DG Sbjct: 278 GQLLLDTAAGRQSIATGDVSLRLADG 303 >B2SWX1.1 B2SWX1_BURPP Biotin/acetyl-CoA-carboxylase ligase Length = 297 Score = 170 bits (430), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 118/266 (44%), Positives = 142/266 (53%), Gaps = 26/266 (9%) Query: 51 VEAVACTGSTNVDLMQRVTSLTR-------PLLLVADRQTAGRGRAGRPWRAAPEDSLTF 103 +E V TGSTN DLM RV +L R P++ VA QTAGRGR GRPW A P ++L F Sbjct: 32 IEIVEETGSTNADLMTRVKALPRKPGALPRPIVRVAYLQTAGRGRRGRPWYAEPGNALLF 91 Query: 104 SLAWRFERPMHALLGLPLAVGVALAEALEVFGV----RPQLKWPNDVLREGAKLAGILIE 159 S+A RP+ L GL LAVGVAL + L V + LKWPNDVL EG KLAGILIE Sbjct: 92 SVACVLPRPLEGLAGLSLAVGVALVDGLRALPVAGPGQIALKWPNDVLLEGDKLAGILIE 151 Query: 160 TASDGRRGDATWAVIGIGLNLGVPQGLEQELQRAIAAVPELRKPPRET------------ 207 TA DA+ VIGIG N+ L ++ A VP + T Sbjct: 152 TAWS--TDDASAVVIGIGTNVKGADELAAKVGALNAGVPPQARGTAPTALQRALPNANLT 209 Query: 208 -VLAIIASALAEVLTEFEQRGFGAFVRRWETFHAYADQAVKIVDNGRLLHEGRAVGVDMM 266 LA +AL L F GF F RW HAYA + V +++ G+ G A GVD Sbjct: 210 DTLAAELNALEPALQRFGAEGFAPFQARWNAVHAYAGREVVLLEQGQEQMRGVAAGVDER 269 Query: 267 GRFLLDTEAGQVAVMVGDLSLRLQDG 292 G+ LLDT G+ V GD+SLRL DG Sbjct: 270 GQLLLDTATGRETVATGDVSLRLADG 295